Atrial fibrillation is the most common sustained arrhythmia and imposes a substantial burden on patients and health-care providers. Clinical evidence suggests that antiarrhythmic therapy to restore and maintain sinus rhythm (rhythm control) can reduce adverse cardiovascular outcomes in patients with new-onset atrial fibrillation. As a result, a paradigm shift towards rhythm control over rate control therapy is emerging, increasing the clinical need for effective and safe antiarrhythmic drugs.

中文翻译：

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房颤的新型药物疗法

心房颤动是最常见的持续性心律失常，给患者和医疗保健提供者带来沉重负担。临床证据表明，恢复和维持窦性心律（节律控制）的抗心律失常治疗可以减少新发房颤患者的不良心血管结局。因此，从心率控制治疗转向节律控制的范式转变正在出现，增加了临床对有效和安全的抗心律失常药物的需求。