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Chronic graft-versus-host disease detected by tissue-specific cell-free DNA methylation biomarkers
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2023 , DOI: 10.1172/jci163541
Batia Avni 1 , Daniel Neiman 2 , Elior Shaked 2 , Ofer Gal-Rosenberg 2 , Sigal Grisariu 1 , Mona Kuzli 1 , Ilai Avni 3 , Andrea Fracchia 1 , Polina Stepensky 1 , Tsila Zuckerman 4 , Ahinoam Lev-Sagie 5 , Ilana Fox-Fisher 2 , Sheina Piyanzin 2 , Joshua Moss 2 , Seth J Salpeter 2 , Benjamin Glaser 6 , Ruth Shemer 2 , Yuval Dor 2
Affiliation  

BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT). Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue turnover and chronic GVHD (cGVHD) in specific organs.

中文翻译:

通过组织特异性游离 DNA 甲基化生物标志物检测慢性移植物抗宿主病

背景。准确检测移植物抗宿主病(GVHD)是造血干细胞移植(HCT)患者管理中的主要挑战。在这里,我们演示了使用循环游离 DNA (cfDNA) 检测特定器官中的组织更新和慢性 GVHD (cGVHD)。
更新日期:2024-01-17
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