The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidative stress, and altered placental function. Here, we review recent research exploring the involvement of inflammation and oxidative stress as mechanisms impacting the placenta and fetus during obese pregnancy. Understanding them is crucial for informing strategies that can mitigate the adverse health effects of maternal obesity on offspring development and disease risk.

中文翻译：

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孕产妇肥胖中的胎盘炎症、氧化应激和胎儿结局

肥胖的流行导致越来越多的研究调查母亲肥胖对怀孕和后代健康的影响。传统上，胎盘被视为母亲和胎儿之间的被动中介，众所周知，它在调节宫内环境和胎儿发育方面发挥着关键作用，现在我们知道，孕妇肥胖会导致炎症增加、氧化应激和胎盘功能改变。在这里，我们回顾了最近的研究，探索炎症和氧化应激作为肥胖妊娠期间影响胎盘和胎儿的机制。了解它们对于制定减轻孕产妇肥胖对后代发育和疾病风险的不利健康影响的策略至关重要。