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Mineralized bacteria as an immunotherapy agent against various cancer types
Nature Biomedical Engineering ( IF 28.1 ) Pub Date : 2024-03-27 , DOI: 10.1038/s41551-024-01192-9


By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multiple immune signalling pathways. Immunotherapy with mineralized bacteria suppressed various types of cancer in multiple animal models, eliciting both immune memory and abscopal antitumour effects.

中文翻译:

矿化细菌作为针对各种癌症类型的免疫治疗剂

通过将二氧化锰涂覆在固定细菌的表面,我们获得了能够有效激活多种免疫信号通路的矿化细菌。矿化细菌的免疫疗法在多种动物模型中抑制了各种类型的癌症,引发了免疫记忆和远隔抗肿瘤作用。
更新日期:2024-03-27
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