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Successful treatment of concurrent cold agglutinin disease and myelodysplastic syndrome Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-25 Rie Tabata, Chiharu Tabata
Herein, we describe a case of severe anemia presenting with myelodysplastic syndrome with cold agglutinin disease that was successfully treated by a moderate dose of steroids followed by cyclosporine. In patients with myelodysplastic syndrome, autoimmunity in erythroid cells is occasionally demonstrated, and autoimmune hemolytic anemia is seen in some patients. However, hemolytic anemia with cold agglutinin
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Serology and molecular genetic analysis of two unrelated individuals with the same novel CisAB blood type Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-25 Tongtong Li, Yongqiang Shan, Xinhua Zhou, Ying Zhao, Lina Wu, Xian Huang, Yang Yang, Jinhui Xie, Jinghui Chong
This study aims to report two unrelated individuals with the same novel CisAB blood type and confirm this rare blood type using a comprehensive approach that combines serological and molecular biology techniques. Peripheral blood samples were collected from two patients and their family members. ABO blood typing and antibody detection were performed using conventional tube methods. Molecular biology
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Determination of optimum levels of binding antibody units (BAU) of new quantitative chemiluminescent immuno-assay (CLIA) in COVID-19 vaccinated volunteer blood donors Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-24 Aseem Kumar Tiwari, Geet Aggarwal, Pratibha Kale, Neeti Yadav, Virendra Kumar, Gargi Singh, K. Cheirmaraj, K. Krishnan
For assessment of COVID-19 vaccine efficacy, neutralization activity of anti-SARS-CoV-2 antibody is measured. This study was undertaken to determine optimum levels of binding antibody units (BAU/ml) in new quantitative chemiluminescent assay (CLIA) that corresponded to neutralizing potential (30% inhibition) of sVNT assay. Methods: Ninety-one blood samples were analyzed by CLIA and sVNT assays. Test
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Focus on: Prognostic scores to predict stem cell mobilization Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-23 Attilio Olivieri, Francesco Saraceni, Amalia De Luca
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Outpatient hospitalist-run procedure service bridges the gap in oncology care Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-21 Ghadi Ghanem, Hsin Hsiang Clarence Tsai, Catherine Durant, Gary S. Feigenbaum, Alexandra Milin Glaeser
Hospitalist-run procedure teams enable expedited care in the inpatient setting. However, wait times for outpatient interventional radiology (IR) are long at our institution. Our study thus aims to compare the safety and wait times between procedural teams and IR placement of outpatient temporary hemodialysis catheters (THDC) for patients undergoing Chimeric antigen receptor T-cell (CAR-T) therapy apheresis
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Novel approaches for hematopoietic stem cell mobilisation and collection need to be assessed for qualification and validation to accomplish the proper requirements of their intended purpose Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-20 Francesco Lanza, Giovanni Marconi
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How to manage poor mobilisers Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-18 Nina Worel
Autologous hematopoietic progenitor cell transplantation (ASCT) has been used for more than five decades to treat malignant and non-malignant diseases. Successful engraftment after high-dose chemotherapy relies on the ability to collect sufficient CD34 + hematopoietic progenitor cells (HPCs), typically from peripheral blood after mobilization. Commonly, either granulocyte colony-stimulating factor
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Editorial comments: Looking for some innovative diagnostic or developmental research studies that might influence our laboratory and clinical decision-making Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-18 Jerard Seghatchian
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Platelet function testing: Update on determinant variables and permissive windows using a platelet-count-based device Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-18 Patricia Villar, Sofía Carreño, Sara Moro, Inés Díez Galindo, Ángel Bernardo, Laura Gutiérrez
While there are various aspects of platelet biology that can be studied in the lab ( adhesion, degranulation, integrin activation), the master test for platelet function is that which gives a measure of the platelet aggregation capacity upon stimulation with an agonist. Platelet function testing is necessary for the diagnosis of platelet disorders and the monitoring of patients receiving anti-platelet
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A perspective on exogenous redox regulation mediated by transfused RBCs subject to the storage lesion Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-18 Nishaka William, Jason P. Acker
Granted with a potent ability to interact with and tolerate oxidative stressors, RBCs scavenge most reactive oxygen and nitrogen species (RONS) generated in circulation. This essential non-canonical function, however, renders RBCs susceptible to damage when vascular RONS are generated in excess, making vascular redox imbalance a common etiology of anemia, and thus a common indication for transfusion
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Impact of ABO blood group on mortality in trauma patients: A systematic review Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-18 Andrew Follows, Antonia Round
Haemorrhage is a significant cause of death in trauma patients. There is evidence that individuals with blood group O have higher rates of non-traumatic haemorrhage. It has been suggested that blood group O may be associated with higher mortality in trauma, however existing evidence is limited and conflicting. A systematic review was conducted to evaluate the impact of ABO blood group on mortality
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Graft collection by apheresis and graft composition Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-17 Luca Pierelli, Anna Capalbo
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Mobilization and collection of CD34 + cells in patients with globin disorders: Providing the starting material to manufacturers of autologous gene therapies Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-17 Christian Chabannon, Sandrine Visentin, Angéla Granata, Isabelle Thuret
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Advancing in vivo assessment of red blood cell transfusions: A call for radiation-free methods in transfusion medicine Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-17 Mahsa Yazdanbakhsh, Jason P. Acker
RBC transfusions are a vital clinical therapy to treat anemic patients. The assessment of red blood cell (RBC) quality post-transfusion is critical to ensuring that the introduction of new RBC products meet established regulatory and clinical quality requirements. Although quality control testing is routinely performed by blood manufacturers, it is crucial that tests are performed during the evaluation
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Prevalence and factors influencing anemia recovery after intensive care Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-16 Kyoung Won Yoon, Sungjoo Park, Chi-Min Park
Anemia is associated with adverse outcomes and prolonged hospitalizations in critically ill patients. Regarding the recent adoption of restrictive transfusion protocols in intensive care unit (ICU) management, anemia remains highly prevalent even after ICU discharge. This study aimed to investigate the prevalence of anemia following ICU discharge and factors affecting recovery from anemia. In this
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Impact of cell salvage on hematocrit and post-partum anemia in low hemorrhage risk elective cesarean delivery Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-16 Daniel Katz, Annalin Griffel, Sarah Granozio, Gary Koenig, Hung-Mo Lin
Postpartum anemia is a significant contributor to peripartum morbidity. The utilization of cell salvage in low risk cases and its impact on postpartum anemia has not been investigated. We therefore aimed to examine the impact of autologous blood transfusion/cell salvage in routine cesarean delivery on postoperative hematocrit and anemia. Retrospective cohort study from a perfusion database from a large
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Molecular and clinical profile of rare bleeding disorders: A single-center retrospective study Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-01 Arash Ahmadfard Moghadam, Amir Reza Manafzadeh, Mohammad Reza Nikoonia, Khadijeh Dajliry, Farahnaz Ramezan, Shadi Tabibian
Due to their low frequency, there is little information on the molecular pathologies of rare bleeding disorders (RBD). Therefore, this study aimed to analyze the molecular and clinical profiles of patients with RBD. A retrospective single-center study was conducted among patients with factor (F) II, FVII, FX, and FXIII deficiencies between March 20, 2000, and June 31, 2023. Data on patient demographics
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Prevention of potential delayed hemolytic transfusion reaction in two sickle cell patients using intravenous immunoglobulins and steroids before and after red blood cell exchange with antigen positive units and review literature Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-04-01 Janna Shold, Amitava Dasgupta, Zhan Ye
Emergent Red Blood Cell (RBC) exchange is indicated in sickle cell disease (SCD) patients with severe acute chest syndrome. However, fully matched RBC units may not be available for patients with multiple RBC antibodies. Intravenous immunoglobulin (IVIG) and steroids were reported for preventing potential delayed hemolytic transfusion reaction (HTR) in simple transfusion of antigen-positive RBCs. We
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Utility of hemoglobin electrophoresis to distinguish between severe delayed hemolytic transfusion reaction versus hyperhemolysis syndrome Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-27 Robert Lukin, Jennie Y. Law, Parvez M. Lokhandwala
Delayed hemolytic transfusion reaction (DHTR) and hyperhemolysis syndrome (HHS) are both complications of red blood cell transfusions in patients with sickle cell disease.Clinically, both present with hemolysis and can be difficult to differentiate. Hemoglobin electrophoresis may aid in the diagnosis. Herein we describe a case in which a patient with hemoglobin SC disease presented with features of
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Impact of therapeutic plasma exchange on intact protein S, apolipoproteins, and thrombin generation Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-27 Hanna H. Pitkänen, Mikko Haapio, Mika Saarela, Marja-Riitta Taskinen, Herm-Jan Brinkman, Riitta Lassila
Therapeutic plasma exchange (TPE), with solvent/detergent (S/D)-treated plasma as replacement fluid, is an extracorporeal blood purification technique with major impact on both coagulation and lipids. Our previous study showed that S/D-plasma enhances thrombin generation by lowering intact protein S (PS) levels. Aims: To evaluate the impact of altered lipid balance on coagulation phenotype during
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Transfusion safety: Is there a difference between reported reactions in low-to-middle income and high-income countries? Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-19 Mohamed Amine Hmida, Sonia Mahjoub, Leila Ben Hamed, Najet Mojaat, Abdessalem Bahloul, Slama Hmida
Transfusion safety may be becoming dependent on the financial resources made available for transfusion structures and may vary between high-income countries (HIC) and low-to-middle-income countries (LMIC). To assess whether there is a difference in the reported TR between these two groups of countries, we examined TR reported in Tunis the capital of Tunisia, a LMIC, and compared their frequency with
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Pain is what hurts: An exploration of perception and management of pain in peripheral blood stem cell donors Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-19 Suzanna M. van Walraven, Leon C. Witte, Femmeke Prinsze, Johanna C. Wiersum-Osselton, Ivan Bank
Pain is a side effect of Granulocyte-Colony Stimulating Factor (G-CSF) administration. This prospective study investigates various aspects including pain perception occurring in Peripheral Blood Stem Cell (PBSC) donors. Related and unrelated PBSC donors were prospectively studied. Donors recorded pain symptoms during the four-day period of G-CSF administration using the McGill Pain Questionnaire, a
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Can SARS-CoV-2 infection cause prolonged pseudothrombocytopenia? A case presentation and literature summary Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-14 Unal Atas, Mustafa Sinanoglu, Volkan Karakus
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Correlation between serum cytokine levels and the effect of allogeneic serum-based eye drops Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-14 Katarzyna Chmielewska, Joanna Janus, Agata Mikołowska, Karolina Wrzodak, Marta Stącel, Jolanta Antoniewicz-Papis
The Institute of Hematology and Transfusion Medicine (IHTM) in Warsaw has produced autologous serum eye drops (ASEDs) for the treatment of Dry Eye Syndrome (DES) since 1991. In 2019, IHTM introduced allogeneic tears (alloSEDs) for patients on long-term treatment. 114 patients who applied alloSEDs were included in the study.They were asked to complete the OSDI questionnaire before and after using ASEDs
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Clinical features and risk factors of hepatic sinusoidal obstruction syndrome in children after hematopoietic stem cell transplantation: A single-center experience Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-08 İbrahim Kartal, Canan Albayrak, Ayhan Dağdemir, Oğuz Salih Dinçer, Hülya Kangal Şimşek, Ünsal Özgen, Davut Albayrak
Hepatic sinusoidal obstruction syndrome (SOS) is an illness with serious life effects that develops after hematopoietic stem cell transplantation (HSCT). We investigated the risk factors and clinical features of hepatic SOS in children following HSCT in 210 children who underwent allogeneic or autologous HSCT between 2009 and 2021 were analyzed in the context of SOS. The syndrome developed in 22 (10
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Is minimizing iatrogenic blood loss the next frontier in transfusion medicine? Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-02 Anubhav Gupta, Romesh Jain
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A RANDOMIZED CONTROL TRIAL FOR EVALUATION OF TRANSFUSION RELATED IMMUNO-MODULATION IN PATIENTS WITH MENINGIOMA Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-21 Gopal Kumar Patidar, Girija Prasad Rath, Anjali Hazarika, Yashaswi Dhiman, Bhagya Ranjan Jena, Deep Sengupta
Blood transfusion necessity in neurosurgery varies based on surgical type, blood loss, and patient anemia. Leukocytes in red blood cells (RBCs) component release pro-inflammatory cytokines during storage, contributing to transfusion-related immunomodulation (TRIM). Our aim was to examine the impact of the leukocyte content in transfused PRBCs on patients undergoing neurosurgery for meningioma tumours
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Spotlight on the knowledge economy in transfusion medicine: Where are we now! Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-21 Dr. Jerard Seghatchian
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Granulocyte transfusions in life-threatening infections of children with hemato-oncological diseases Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-20 Esra Arslantaş, Kamuran Şanlı, Sultan Okur Acar, Sibel Akpınar Tekgündüz, Ali Ayçiçek
Granulocytes are the most important cells for host defense during infections. Granulocyte suspension transfusions (GTx) may be given as additional treatment in severely neutropenic patients with life-threatening infections when antimicrobial therapy is inadequate. The aim of this study was to evaluate the effectiveness and safety of GTx for the treatment of children with hemato-oncological disease
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Second line extracorporeal photopheresis for cortico-resistant acute and chronic GVHD after allogeneic hematopoietic cell transplantation for hematological malignancies: Long-term results from a real-life study Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-16 Mauricette Michallet, Mohamad Sobh, Alexandre Deloire, Daniela Revesz, Youcef Chelgoum, Mohamed El-Hamri, Fiorenza Barraco, Helene Labussiere, Franck E. Nicolini, Olivier Hequet
The primary objective of this observational study was to perform an exhaustive description concerning patients receiving extracorporeal photopheresis (ECP) as second line treatment after steroid resistance for either acute or chronic GVHD following allo-HCT, secondary objectives were to evaluate the efficacy and long-term outcomes. A total of 106 patients were included, 65 (61%) males and 41 (39%)
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Severe jaundice with life-threatening liver failure after Kratom use: Reversed by plasma exchange Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-08 Amitava Dasgupta, Zhan Ye
Kratom is an herbal supplement which is used for its stimulating properties and pain reduction due to interaction with opioid receptors. Kratom overdose may cause fatality. A 56-year-old man was admitted to the emergency department with severe jaundice and liver failure. His total bilirubin reached at 70.6 mg/dL, but extensive workup did not show any liver mass. Family informed that the patient was
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Impact of peri-operative red blood cell transfusions for treatment of anemia on acute rejection in renal transplant recipients Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-07 Demetra Tsapepas, Adarsh Ramakrishnan, David M. Salerno, Syed Ali Husain, Kristen King, Sumit Mohan
Anemia occurs before and after kidney transplantation. Determining the impact of perioperative transfusion on post-transplant outcomes can help determine best management of anemia. The current study aims to describe clinical outcomes associated with packed red blood cell transfusions in the peri-operative management of anemia after transplantation. This was a single-center, retrospective study of adult
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Guest Editor’s Bios Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-07 Viktoria Weber, Tanja Eichhorn
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Has the knowledge economy a role to play in transfusion medicine? Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Cornelis Theodoor Smit Sibinga
The history of blood transfusion has been dominated by the search for compatibility for species specificity, the search for how to transfer blood from one individual into another or infuse. Safety has become a major issue since it became clear that blood was not only able to allow mystical miracles to take place but could transmit infectious diseases. The science behind these ideas reflects observation
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Nurses' self-efficiency levels in safe blood and blood component transfusion: The case of Turkey Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Aynur Kaynar Simsek (Şimşek), Sule (Şule) Ecevit Alpar, Nazan Cayli (Çaylı)
The study aimed to determine nurses' self-efficacy levels for safe transfusion of blood and blood components. The design of this study is descriptive and cross-sectional. Before starting the study, ethics committee approval and institution approval was obtained. The participants were informed about the purpose of the study, and their written consent was obtained. The research was conducted between
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Impact of production methods and storage conditions on extracellular vesicles in packed red blood cells and platelet concentrates Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Marie Ebeyer-Masotta, Tanja Eichhorn, Michael B. Fischer, Viktoria Weber
The use of blood and blood products can be life-saving, but there are also certain risks associated with their administration and use. Packed red blood cells (pRBCs) and platelet concentrates are the most commonly used blood products in transfusion medicine to treat anemia or acute and chronic bleeding disorders, respectively. During the production and storage of blood products, red blood cells and
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Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Stephanie Sisak, Ryan C. Chae, Kamala E. Nelson, Rebecca M. Schuster, Emma C. Perez, Lisa G. England, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
The use of packed red blood cells (pRBCs) for resuscitation is limited by the red blood cell storage lesion, a series of biochemical and physiological changes that occur during the storage and aging of blood. Microvesicles (MVs) shed from pRBCs during this process are one component of the red blood cell storage lesion and lead to acute lung injury and pulmonary vascular microthrombi. We hypothesized
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Extracellular vesicles in blood products Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Viktoria Weber, Tanja Eichhorn
Abstract not available
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Spotlights on the trends in performance assessment of qualitative in vitro diagnostic medical devices in transfusion medicine Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-01 Paulo Pereira, Jerard Seghatchian
For reliable clinical decisions in transfusion medicine, assessing the performance of qualitative tests performed in medical laboratories is critical. When false results are reported, these can lead to an adverse reaction to blood components. Good performance assessment practices are essential for this kind of scenario, and they still remain as one of the many unmet high-priority challenges in this
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Characteristics of unexpected antibodies in patients with blood disorders: Evidence in Vietnam Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-28 Vu Duc Binh, Hoang Thi Thanh Nga, Nguyen Ha Thanh, Nguyen Hoang Thanh, Le Phu Tai, Nguyen Quang Hung
In Vietnam, a lack of evidence about the unexpected antibodies hinders the capabilities to prepare the necessary resources and personnel for treating patients with blood disorders. This study aimed to measure the rates of different unexpected antibodies in patients having blood orders in Vietnam. Study design and methods: A cross-sectional study was conducted at the National Institute of Hematology
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Plasma-reduction for Apheresis Granulocyte transfusions in pediatric patients Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-26 Yujung Jung, Kanwaldeep K. Mallhi, Kirsten Alcorn, Nabiha H. Saifee
Granulocyte transfusion (GT) may be used to treat and prevent infections in patients with severe neutropenia or nonfunctioning granulocytes. For pediatric patients, the volume of granulocyte unit transfused is a crucial consideration given smaller blood volume and increased risk of volume overload compared to adults. There is limited literature on the optimal dosing or the maximum amount of granulocytes
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Molecular basis of DEL phenotype in the Indian population: Insights from next-generation sequencing analysis of two cases Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-22 Mercy Rophina, Ayesha Sinha, Durba Biswas, Debapriya Basu, Suvro Sankha Datta, Vinod Scaria
The DEL phenotype represents an intriguing and challenging aspect of blood group serology. This condition is characterized by an extremely weak expression of the D antigen on red blood cells, to the extent that it often eludes detection through routine serological methods. Identifying the DEL phenotype necessitates more specialized techniques, such as adsorption and elution tests, to reveal the presence
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New threats from an old foe: Evaluating the risk to the blood supply due to increasing incidence and endemicity of leprosy in the United States Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-14 Jeremy W. Jacobs, Brian D. Adkins, Lorin A. Bibb, Laura D. Stephens, Jennifer S. Woo, Evan M. Bloch, Garrett S. Booth
Leprosy (i.e., Hansen’s disease) is a chronic disease secondary to infection with either Mycobacterium leprae or M. lepromatosis. While the incidence of this disease is decreasing across the world, there is mounting evidence that it might be increasing, and becoming endemic, in the United States. Leprosy was once considered a potential threat to the blood supply, and while this threat has not borne
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In-house RT-PCR detection of hepatitis A virus in human plasma pools used for the manufacture of medicinal products Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-12 Luciana Sampieri, Gonzalo Rodríguez-Lombardi, María Eugenia Bernardi
Hepatitis A virus (HAV) is the most frequent cause of viral hepatitis worldwide and is transmitted through the fecal-oral route. However, HAV can also be transmitted by blood-derived products. This is due to the fact that viremia occurs during the asymptomatic phase of HAV infection, enabling infected blood or plasma donations to occur. Viral inactivation/removal steps are included during manufacturing
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Red Ribbon Club inculcation of positive deviance approach to promote blood donation among undergraduate medical college students Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-12 Reenaa Mohan, M. Arulmozhi, R. Sindhuri, Pravin Surendran, J. Jenifer Florence Mary, Kalaiselvan Ganapathy
Blood is an essential part of human life and blood donation has become a necessity that every society must take into consideration. Health care professionals have a major responsibility in raising community awareness on blood donation. This study aims to find out the knowledge and attitude of undergraduate medical students on blood donation and to determine the effectiveness of positive deviance (PD)
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Risk of new alloimmunization in patients on anti-CD38 treatment using tube LISS-IAT method Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-12 Hana Safić Stanić, Zrinka Kruhonja Galić, Martina Lukić, Jasna Bingulac-Popović, Irena Jukić
Daratumumab is a monoclonal antibody that targets CD38, a transmembrane protein expressed on many cells including RBCs and to a greater extent on myeloma cells. It has been used for treatment of multiple myeloma and autoimmune diseases. Transfusion management of patients on such therapy can be challenging as these drugs cross-react with RBC surface antigens and cause panreactivity. A retrospective
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Insights on trends in the management of metrological analysis of devices in blood and transfusion medicine services: Verification based on their fitness for purpose and suitability for their respective applications Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-11 Helga Gonçalves, Carla Rodrigues, Hugo F. Silva, Paulo Pereira
In the field of blood and transfusion medicine, European Directorate for the Quality of Medicines & HealthCare recommends practices for metrological devices. Monitoring and measurement resources, as well as their permitted metrological limits, must be considered in this regard. We must understand variables such as metrological domains, the International System of Units, metrological traceability, and
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Current principles for the establishment of the virological “cutoff points” in transfusion science and medicine: A short concise overview Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-11 P, a, u, l, o, , P, e, r, e, i, r, a
Establishing the virological cutoff point, during epidemics, such as the COVID-19 Pandemic, is crucially important as inadequate standardization and the false qualitative results, have enormous clinical and economic consequences when screening for SARS-CoV-2. Moreover, a cutoff point is a crucial step in ensuring a minimal risk of clinical misclassification. Therefore complying with such statutory
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A targeted survey on teachers’ perception of training/education for blood donation in high school students: An invited case report for enhancing and retention of dedicated donors in Portugal Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-11 Lídia Matos, Irene Morgado, Luís Santos, Rui Camisa, Paulo Benvindo, Paulo Pereira
Promoting blood donation requires understanding and identifying the factors that motivate donations so that strategies for retaining and increasing loyalty can be developed. Transfusion literacy can be improved through school-based teaching and information about giving and solidarity to promote the development of future donors. For the purpose of aligning any strategies and motivational dynamics that
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Treatment with plasma exchange of a pregnant woman with anti-PP1Pk alloimmunization: A case report Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-10 O. Pignalosa, E. Vigorita, M. Capuano, S. Caruso, A. Mastroianni, S. De Martino, G. Vaccaro, D. Meomartini, C. Nocera
The histo-blood group antigens P, P1 and Pk are a closely related set of glycosphingolipid structures expressed by red blood cells and other tissues. None of these three characters is expressed on p cells, a null phenotype that arises in the context of homozygous mutation of the A4GALT gene. Subjects with p phenotype spontaneously develop a natural alloantibody named anti-PP1Pk, which is a mixture
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Successful management of severe Kell alloimmunization in pregnancy with intravenous immune globulin Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-05 Marie Patris, Anne Holoye, Deborah Goldman, Caroline De Coninck, Martin Colard
Hemolytic Disease of the Fetus and Newborn (HDFN) is a condition that affects 1 to 2 out of 1000 patients during pregnancy (1). When an alloantibody is present, it is essential to identify its nature in order to organize appropriate follow-up. Kell-mediated HDFN is rare; it occurs in about 5% of Kell alloimmunized pregnant women. It is important to note that in case of anti-Kell immunization, the severity
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The Polish adaptation of the blood donation fears inventory Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-28 P, a, w, e, ł, , K, o, s, o, w, s, k, i
Given the decline in the number of voluntary blood donors in Poland and the lack of psychological research on blood donors and the donation system in the country, there is a need to develop a tool to measure barriers to recruiting new donors and retaining active donors. One significant barrier is the presence of specific fears associated with the blood donation process. Therefore, the main objective
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Anemia in patients undergoing chronic therapeutic plasma exchange Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-28 Nichole LePage, Esther Soundar
Therapeutic plasma exchange is known to be an extracorporeal treatment procedure with few adverse effects. Anemia in chronically exchanged patients is not a well-recognized adverse effect. Our aim is to find if adult patients develop anemia while undergoing prolonged TPE treatments and to determine the time of onset of anemia. We retrospectively reviewed all outpatients that have undergone TPE at least
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In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-20 Zhongfeng Liu, Weihua Liu, Zhiguo Chen, Hua Kang
Hematopoietic stem cells (HSCs) represent crucial target cells in the management of hematopoietic and immune system disorders. Unfortunately, the primary source of hematopoietic stem cells is limited. Hematopoietic stem cells derived from induced pluripotent stem cells (iPSCs) hold great promise for applications in cell therapy, disease modeling, and drug screening. To achieve a consistent induction
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A study on diagnostic performance of different immunohematological diagnostic tests in assessing the prevalence of ABO Hemolytic Disease of Newborn in the antenatal O group mothers and their neonatal outcome in a tertiary care hospital in Northern India Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-13 Joyisa Deb, Ashish Jain, Daljit Kaur, Anupama Bahadur, Sriparna Basu, Gita Negi
Hemolytic disease of the newborn (HDN) results in the decreased lifespan of the red cells. HDN related to ABO incompatibility is mostly unnoticed because routine screening is not being done. This study was done to assess the prevalence of ABO-HDN and to compare different immunohematological tests. Methods-In this study 213 O group mothers and the 122 ABO-incompatible newborns born to them were included
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The Italian registry of therapeutic apheresis in SISTRA: Year of activity 2022 Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-04 Giustina De Silvestro, Liviana Catalano, Giuseppe Marano, Vanessa Piccinini, Simonetta Pupella, Angelo Ostuni, Vincenzo De Angelis
Therapeutic apheresis refers to a group of extracorporeal blood processing procedures used in the treatment of a variety of systemic diseases. These complex procedures are burdened by adverse reactions related to both procedures and underlying medical conditions.
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I-JAMM-(I): A survey providing an insight into the practices of isoagglutinin titration in ABO incompatible kidney and liver transplantation Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-04 Prashant Pandey, Aseem Tiwari, Sudipta Shekhar Das, Shamee Shastry, Vivek Kute, Mohit Chowdhry, Arghyadeep Marik, Geet Aggarwal, Supriya Kumari, Divya Setya, Saikat Mandal, Shweta Ranjan
ABO-incompatible transplantations allow patients to receive timely transplants. Isoagglutinin titration to ascertain levels of incompatible antibodies in the recipient is important in determining patient selection and transplant survivability. To find out the prevalent trends in India, the largest, first of its kind survey was carried out among the transplant centers regarding their practices in isoagglutinin