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Can SARS-CoV-2 Infection Cause Prolonged Pseudothrombocytopenia? A Case Presentation and Literature Summary Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-14 Unal Atas, Mustafa Sinanoglu, Volkan Karakus
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Correlation between serum cytokine levels and the effect of allogeneic serum-based eye Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-14 Katarzyna Chmielewska, Joanna Janus, Agata Mikołowska, Karolina Wrzodak, Marta Stącel, Jolanta Antoniewicz-Papis
The Institute of Hematology and Transfusion Medicine (IHTM) in Warsaw has produced autologous serum eye drops (ASEDs) for the treatment of Dry Eye Syndrome (DES) since 1991. In 2019, IHTM introduced allogeneic tears (alloSEDs) for patients on long-term treatment. 114 patients who applied alloSEDs were included in the study.They were asked to complete the OSDI questionnaire before and after using ASEDs
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Clinical features and risk factors of hepatic sinusoidal obstruction syndrome in children after hematopoietic stem cell transplantation: A single-center experience Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-08 İbrahim Kartal, Canan Albayrak, Ayhan Dağdemir, Oğuz Salih Dinçer, Hülya Kangal Şimşek, Ünsal Özgen, Davut Albayrak
Hepatic sinusoidal obstruction syndrome (SOS) is an illness with serious life effects that develops after hematopoietic stem cell transplantation (HSCT). We investigated the risk factors and clinical features of hepatic SOS in children following HSCT in 210 children who underwent allogeneic or autologous HSCT between 2009 and 2021 were analyzed in the context of SOS. The syndrome developed in 22 (10
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Is minimizing iatrogenic blood loss the next frontier in transfusion medicine? Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-03-02 Anubhav Gupta, Romesh Jain
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A RANDOMIZED CONTROL TRIAL FOR EVALUATION OF TRANSFUSION RELATED IMMUNO-MODULATION IN PATIENTS WITH MENINGIOMA Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-21 Gopal Kumar Patidar, Girija Prasad Rath, Anjali Hazarika, Yashaswi Dhiman, Bhagya Ranjan Jena, Deep Sengupta
Blood transfusion necessity in neurosurgery varies based on surgical type, blood loss, and patient anemia. Leukocytes in red blood cells (RBCs) component release pro-inflammatory cytokines during storage, contributing to transfusion-related immunomodulation (TRIM). Our aim was to examine the impact of the leukocyte content in transfused PRBCs on patients undergoing neurosurgery for meningioma tumours
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Granulocyte transfusions in life-threatening infections of children with hemato-oncological diseases Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-20 Esra Arslantaş, Kamuran Şanlı, Sultan Okur Acar, Sibel Akpınar Tekgündüz, Ali Ayçiçek
Granulocytes are the most important cells for host defense during infections. Granulocyte suspension transfusions (GTx) may be given as additional treatment in severely neutropenic patients with life-threatening infections when antimicrobial therapy is inadequate. The aim of this study was to evaluate the effectiveness and safety of GTx for the treatment of children with hemato-oncological disease
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Second line extracorporeal photopheresis for cortico-resistant acute and chronic GVHD after allogeneic hematopoietic cell transplantation for hematological malignancies: Long-term results from a real-life study Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-16 Mauricette Michallet, Mohamad Sobh, Alexandre Deloire, Daniela Revesz, Youcef Chelgoum, Mohamed El-Hamri, Fiorenza Barraco, Helene Labussiere, Franck E. Nicolini, Olivier Hequet
The primary objective of this observational study was to perform an exhaustive description concerning patients receiving extracorporeal photopheresis (ECP) as second line treatment after steroid resistance for either acute or chronic GVHD following allo-HCT, secondary objectives were to evaluate the efficacy and long-term outcomes. A total of 106 patients were included, 65 (61%) males and 41 (39%)
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The WAA-registry Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-15 Just Volker Witt, Bernd Stegmayr
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Severe jaundice with life-threatening liver failure after Kratom use: Reversed by plasma exchange Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-08 Amitava Dasgupta, Zhan Ye
Kratom is an herbal supplement which is used for its stimulating properties and pain reduction due to interaction with opioid receptors. Kratom overdose may cause fatality. A 56-year-old man was admitted to the emergency department with severe jaundice and liver failure. His total bilirubin reached at 70.6 mg/dL, but extensive workup did not show any liver mass. Family informed that the patient was
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Impact of peri-operative red blood cell transfusions for treatment of anemia on acute rejection in renal transplant recipients Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-07 Demetra Tsapepas, Adarsh Ramakrishnan, David M. Salerno, Syed Ali Husain, Kristen King, Sumit Mohan
Anemia occurs before and after kidney transplantation. Determining the impact of perioperative transfusion on post-transplant outcomes can help determine best management of anemia. The current study aims to describe clinical outcomes associated with packed red blood cell transfusions in the peri-operative management of anemia after transplantation. This was a single-center, retrospective study of adult
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Guest Editor’s Bios Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-07 Viktoria Weber, Tanja Eichhorn
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Extracellular vesicles in blood products Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-06 Viktoria Weber, Tanja Eichhorn
Abstract not available
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Has the knowledge economy a role to play in transfusion medicine? Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Cornelis Theodoor Smit Sibinga
The history of blood transfusion has been dominated by the search for compatibility for species specificity, the search for how to transfer blood from one individual into another or infuse. Safety has become a major issue since it became clear that blood was not only able to allow mystical miracles to take place but could transmit infectious diseases. The science behind these ideas reflects observation
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Nurses' self-efficiency levels in safe blood and blood component transfusion: The case of Turkey Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Aynur Kaynar Simsek (Şimşek), Sule (Şule) Ecevit Alpar, Nazan Cayli (Çaylı)
The study aimed to determine nurses' self-efficacy levels for safe transfusion of blood and blood components. The design of this study is descriptive and cross-sectional. Before starting the study, ethics committee approval and institution approval was obtained. The participants were informed about the purpose of the study, and their written consent was obtained. The research was conducted between
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Impact of production methods and storage conditions on extracellular vesicles in packed red blood cells and platelet concentrates Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Marie Ebeyer-Masotta, Tanja Eichhorn, Michael B. Fischer, Viktoria Weber
The use of blood and blood products can be life-saving, but there are also certain risks associated with their administration and use. Packed red blood cells (pRBCs) and platelet concentrates are the most commonly used blood products in transfusion medicine to treat anemia or acute and chronic bleeding disorders, respectively. During the production and storage of blood products, red blood cells and
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Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-05 Stephanie Sisak, Ryan C. Chae, Kamala E. Nelson, Rebecca M. Schuster, Emma C. Perez, Lisa G. England, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
The use of packed red blood cells (pRBCs) for resuscitation is limited by the red blood cell storage lesion, a series of biochemical and physiological changes that occur during the storage and aging of blood. Microvesicles (MVs) shed from pRBCs during this process are one component of the red blood cell storage lesion and lead to acute lung injury and pulmonary vascular microthrombi. We hypothesized
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Spotlights on the trends in performance assessment of qualitative in vitro diagnostic medical devices in transfusion medicine Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-02-01 Paulo Pereira, Jerard Seghatchian
For reliable clinical decisions in transfusion medicine, assessing the performance of qualitative tests performed in medical laboratories is critical. When false results are reported, these can lead to an adverse reaction to blood components. Good performance assessment practices are essential for this kind of scenario, and they still remain as one of the many unmet high-priority challenges in this
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Characteristics of Unexpected Antibodies in Patients with Blood Disorders: Evidence in Vietnam Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-28 Vu Duc Binh, Hoang Thi Thanh Nga, Nguyen Ha Thanh, Nguyen Hoang Thanh, Le Phu Tai, Nguyen Quang Hung
Background In Vietnam, a lack of evidence about the unexpected antibodies hinders the capabilities to prepare the necessary resources and personnel for treating patients with blood disorders. This study aimed to measure the rates of different unexpected antibodies in patients having blood orders in Vietnam. Study design and methods: A cross-sectional study was conducted at the National Institute of
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Plasma-reduction for Apheresis Granulocyte Transfusions in Pediatric Patients Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-26 Yujung Jung, Kanwaldeep K. Mallhi, Kirsten Alcorn, Nabiha H Saifee
Granulocyte transfusion (GT) may be used to treat and prevent infections in patients with severe neutropenia or nonfunctioning granulocytes. For pediatric patients, the volume of granulocyte unit transfused is a crucial consideration given smaller blood volume and increased risk of volume overload compared to adults. There is limited literature on the optimal dosing or the maximum amount of granulocytes
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Molecular basis of DEL phenotype in the Indian population: Insights from next-generation sequencing analysis of two cases Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-22 Mercy Rophina, Ayesha Sinha, Durba Biswas, Debapriya Basu, Suvro Sankha Datta, Vinod Scaria
The DEL phenotype represents an intriguing and challenging aspect of blood group serology. This condition is characterized by an extremely weak expression of the D antigen on red blood cells, to the extent that it often eludes detection through routine serological methods. Identifying the DEL phenotype necessitates more specialized techniques, such as adsorption and elution tests, to reveal the presence
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New threats from an old foe: evaluating the risk to the blood supply due to increasing incidence and endemicity of leprosy in the United States Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-14 Jeremy W. Jacobs, Brian D. Adkins, Lorin A. Bibb, Laura D. Stephens, Jennifer S. Woo, Evan M. Bloch, Garrett S. Booth
Leprosy (i.e., Hansen’s disease) is a chronic disease secondary to infection with either Mycobacterium leprae or M. lepromatosis. While the incidence of this disease is decreasing across the world, there is mounting evidence that it might be increasing, and becoming endemic, in the United States. Leprosy was once considered a potential threat to the blood supply, and while this threat has not borne
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In-house RT-PCR detection of hepatitis A virus in human plasma pools used for the manufacture of medicinal products Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-12 Luciana Sampieri, Gonzalo Rodríguez-Lombardi, María Eugenia Bernardi
Hepatitis A virus (HAV) is the most frequent cause of viral hepatitis worldwide and is transmitted through the fecal-oral route. However, HAV can also be transmitted by blood-derived products. This is due to the fact that viremia occurs during the asymptomatic phase of HAV infection, enabling infected blood or plasma donations to occur. Viral inactivation/removal steps are included during manufacturing
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Red Ribbon Club Inculcation of Positive Deviance Approach to Promote Blood Donation among Undergraduate Medical College Students Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-12 Reenaa Mohan, M Arulmozhi, R Sindhuri, Pravin Surendran, J Jenifer Florence Mary, Kalaiselvan Ganapathy
Background Blood is an essential part of human life and blood donation has become a necessity that every society must take into consideration. Health care professionals have a major responsibility in raising community awareness on blood donation. Objective This study aims to find out the knowledge and attitude of undergraduate medical students on blood donation and to determine the effectiveness of
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Risk of new alloimmunization in patients on anti-CD38 treatment using tube LISS-IAT method Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-12 Safić Stanić Hana, Kruhonja Galić Zrinka, Lukić Martina, Bingulac-Popović Jasna, Jukić Irena
Background Daratumumab is a monoclonal antibody that targets CD38, a transmembrane protein expressed on many cells including RBCs and to a greater extent on myeloma cells. It has been used for treatment of multiple myeloma and autoimmune diseases. Transfusion management of patients on such therapy can be challenging as these drugs cross-react with RBC surface antigens and cause panreactivity. Material
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TREATMENT WITH PLASMA EXCHANGE OF A PREGNANT WOMAN WITH ANTI-PP1PK ALLOIMMUNIZATION: A CASE REPORT Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-10 O. Pignalosa, E. Vigorita, M. Capuano, S. Caruso, A. Mastroianni, S. De Martino, G. Vaccaro, D. Meomartini, C. Nocera
The histo-blood group antigens P, P1 and Pk are a closely related set of glycosphingolipid structures expressed by red blood cells and other tissues. None of these three characters is expressed on p cells, a null phenotype that arises in the context of homozygous mutation of the A4GALT gene. Subjects with p phenotype spontaneously develop a natural alloantibody named anti-PP1Pk, which is a mixture
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Insights on trends in the management of metrological analysis of devices in blood and transfusion medicine services: Verification based on their fitness for purpose and suitability for their respective applications Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-11 Helga Gonçalves, Carla Rodrigues, Hugo F. Silva, Paulo Pereira
In the field of blood and transfusion medicine, European Directorate for the Quality of Medicines & HealthCare recommends practices for metrological devices. Monitoring and measurement resources, as well as their permitted metrological limits, must be considered in this regard. We must understand variables such as metrological domains, the International System of Units, metrological traceability, and
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Current principles for the establishment of the virological “cutoff points” in transfusion science and medicine: A short concise overview Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-11 P, a, u, l, o, , P, e, r, e, i, r, a
Establishing the virological cutoff point, during epidemics, such as the COVID-19 Pandemic, is crucially important as inadequate standardization and the false qualitative results, have enormous clinical and economic consequences when screening for SARS-CoV-2. Moreover, a cutoff point is a crucial step in ensuring a minimal risk of clinical misclassification. Therefore complying with such statutory
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A targeted survey on teachers’ perception of training/education for blood donation in high school students: An invited case report for enhancing and retention of dedicated donors in Portugal Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-11 Lídia Matos, Irene Morgado, Luís Santos, Rui Camisa, Paulo Benvindo, Paulo Pereira
Promoting blood donation requires understanding and identifying the factors that motivate donations so that strategies for retaining and increasing loyalty can be developed. Transfusion literacy can be improved through school-based teaching and information about giving and solidarity to promote the development of future donors. For the purpose of aligning any strategies and motivational dynamics that
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Successful management of severe Kell alloimmunization in pregnancy with intravenous immune globulin Transfus. Apher. Sci. (IF 1.9) Pub Date : 2024-01-05 Marie Patris, Anne Holoye, Deborah Goldman, Caroline De Coninck, Martin Colard
Hemolytic Disease of the Fetus and Newborn (HDFN) is a condition that affects 1 to 2 out of 1000 patients during pregnancy (1). When an alloantibody is present, it is essential to identify its nature in order to organize appropriate follow-up. Kell-mediated HDFN is rare; it occurs in about 5% of Kell alloimmunized pregnant women. It is important to note that in case of anti-Kell immunization, the severity
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The Polish adaptation of the blood donation fears inventory Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-28 P, a, w, e, ł, , K, o, s, o, w, s, k, i
Given the decline in the number of voluntary blood donors in Poland and the lack of psychological research on blood donors and the donation system in the country, there is a need to develop a tool to measure barriers to recruiting new donors and retaining active donors. One significant barrier is the presence of specific fears associated with the blood donation process. Therefore, the main objective
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Anemia in patients undergoing chronic therapeutic plasma exchange Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-28 Nichole LePage, Esther Soundar
Therapeutic plasma exchange is known to be an extracorporeal treatment procedure with few adverse effects. Anemia in chronically exchanged patients is not a well-recognized adverse effect. Our aim is to find if adult patients develop anemia while undergoing prolonged TPE treatments and to determine the time of onset of anemia. We retrospectively reviewed all outpatients that have undergone TPE at least
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In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-20 Zhongfeng Liu, Weihua Liu, Zhiguo Chen, Hua Kang
Hematopoietic stem cells (HSCs) represent crucial target cells in the management of hematopoietic and immune system disorders. Unfortunately, the primary source of hematopoietic stem cells is limited. Hematopoietic stem cells derived from induced pluripotent stem cells (iPSCs) hold great promise for applications in cell therapy, disease modeling, and drug screening. To achieve a consistent induction
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A study on diagnostic performance of different immunohematological diagnostic tests in assessing the prevalence of ABO Hemolytic Disease of Newborn in the antenatal O group mothers and their neonatal outcome in a tertiary care hospital in Northern India Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-13 Joyisa Deb, Ashish Jain, Daljit Kaur, Anupama Bahadur, Sriparna Basu, Gita Negi
Hemolytic disease of the newborn (HDN) results in the decreased lifespan of the red cells. HDN related to ABO incompatibility is mostly unnoticed because routine screening is not being done. This study was done to assess the prevalence of ABO-HDN and to compare different immunohematological tests. Methods-In this study 213 O group mothers and the 122 ABO-incompatible newborns born to them were included
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The Italian registry of therapeutic apheresis in SISTRA: Year of activity 2022 Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-04 Giustina De Silvestro, Liviana Catalano, Giuseppe Marano, Vanessa Piccinini, Simonetta Pupella, Angelo Ostuni, Vincenzo De Angelis
Therapeutic apheresis refers to a group of extracorporeal blood processing procedures used in the treatment of a variety of systemic diseases. These complex procedures are burdened by adverse reactions related to both procedures and underlying medical conditions.
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I-JAMM-(I): A survey providing an insight into the practices of isoagglutinin titration in ABO incompatible kidney and liver transplantation Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-12-04 Prashant Pandey, Aseem Tiwari, Sudipta Shekhar Das, Shamee Shastry, Vivek Kute, Mohit Chowdhry, Arghyadeep Marik, Geet Aggarwal, Supriya Kumari, Divya Setya, Saikat Mandal, Shweta Ranjan
ABO-incompatible transplantations allow patients to receive timely transplants. Isoagglutinin titration to ascertain levels of incompatible antibodies in the recipient is important in determining patient selection and transplant survivability. To find out the prevalent trends in India, the largest, first of its kind survey was carried out among the transplant centers regarding their practices in isoagglutinin
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In situ and in vitro evaluation of two antiseptics for blood bank based on chlorhexidine gluconate/isopropyl alcohol and povidone-iodine Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-25 María de Jesús Sánchez-Guzmán, Miguel Ángel Loyola-Cruz, Adolfo López-Ornelas, Clemente Cruz-Cruz, Emilio Mariano Durán-Manuel, Juan Manuel Bello-López
Poor disinfection is the main cause of blood contamination, so its elimination is key to limiting the entry of bacteria into the collection system. With the advancement of antiseptic technology, antiseptics with sterile, disposable applicators are now available. To evaluate in situ two antiseptics (with and without applicators) for blood banks and to demonstrate in vitro antiseptic activity on bacterial
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Use of Therapeutic Apheresis methods in Neurology patients Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-24 Ioannis Griveas, Evaggelos Pratilas, Paraskevi Tseke
The therapeutic apheresis consists of a continuously improving therapeutic method for diseases with high mortality and morbidity, especially in cases with poor outcome by using current medications. Neurology is one the most famous and at the same most interesting era of apheresis intervention in clinical practice.
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Guest Editors Bio Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-22 I, o, a, n, n, i, s, , G, r, i, v, e, a, s
Abstract not available
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Editorial commentary Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-21 J, e, r, a, r, d, , S, e, g, h, a, t, c, h, i, a, n
Abstract not available
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Use of Therapeutic Apheresis methods in ICU Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-21 Xanthi Zikou, Derveni Vaia, Polychronidou Vasiliki, Chlorokostas Panagiotis, Aloizos Stavros
Apheresis is a modern medical approach in which plasma or cellular components are separated from the whole blood. Apheresis can be either diagnostic or therapeutic. Diagnostic apheresis is typically applied in hematology and cancer research. Therapeutic Apheresis (TA) includes a broad spectrum of extracorporeal treatments applied in various medical specialties, including Intensive Care Unit (ICU).
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Therapeutic Apheresis and Nephrologist: New and old aspects Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-20 I, o, a, n, n, i, s, , G, r, i, v, e, a, s
The clinical efficacy of therapeutic apheresis is still controversial. We undertook a retrospective review of apheresis treatment to ascertain its safety and efficacy. The therapeutic apheresis consists of a continuously improving therapeutic method for diseases with high mortality and morbidity, especially in cases with poor outcome by using current medications.
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Therapeutic Apheresis in Renal Transplantation: an update Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-17 Melexopoulou Christina, Filiopoulos Vassilis, Marinaki Smaragdi
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates
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Plasma exchange in patients with ANCA-associated vasculitis Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-17 Aglaia Chalkia, Dimitrios Petras
ANCA-associated Vasculitides (AAV) are characterized by small vessel necrotizing inflammation and can present with multisystem organ involvement, including organ/life threatening manifestations of rapidly progressive glomerulonephritis and diffuse alveolar haemorrhage, where immediate and aggressive intervention is needed to prevent further organ damage. Although, the rationale of plasma exchange (PLEX)
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Use of therapeutic apheresis methods during pregnancy Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-15 Paraskevi Tseke, Petros Tsekes, Ioannis Griveas
This review will focus on the current application of TA in pregnancy and possible aspects for future studies. It seems that scientific interest and field for further research in pregnancy is lately focused in specific removal of pathogens implicated in the physiologic mechanism of pre-eclampsia/HELLP syndrome as well as recurrent pregnancy failure.
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Stem Cells mobilization and collection in allogeneic related and unrelated donors: a single center experience with focus on plerixafor Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-03 Chiara Marcon, Antonella Bertone, Sara Mauro, Rosalba Mestroni, Giulia Battaglia, Umberto Pizzano, Gabriele Facchin, Maria De Martino, Miriam Isola, Francesca Patriarca, Giovanni Barillari, Chiara Savignano
Introduction Poor CD34 + cells mobilization in allogeneic donors could affect transplant outcome. In a subgroup of patient mobilization with granulocyte colony-stimulating factor (G-CSF) alone is unsatisfactory, and Plerixafor could be used to enhance CD34 + cells release from bone marrow niche. Materials and methods We conducted a retrospective single-center, cohort study on healthy allogeneic donors
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Therapeutic apheresis in renal transplantation: An update Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-11-03 Christina Melexopoulou, Vassilis Filiopoulos, Smaragdi Marinaki
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates
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Apheresis practices in India: Progress and future scope Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-31 Gopal Kumar Patidar, Hem Chandra Pandey, Rahul Chaurasia
Abstract not available
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Guest editor’s bio Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-31 Francesco Lanza
Abstract not available
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Connectivity in transfusion medicine: Challenges, benefits, and goals Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-26 Aspen King, Guillem Beltran Arroyos, Nicolas Cellier, Steve Durgacharan, Maria Kerr, Luis Larrea, Marcia Cardoso
Transfusion medicine requires meticulous record keeping from the time a blood donation is made to the time a patient receives a transfusion. As such, blood collection establishments and processing laboratories generate large amounts of data. This data must be managed, analyzed, and visualized appropriately to ensure safety of the blood supply. Today, the use of information technology (IT) solutions
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Cerebral and intestinal oxygen saturation of different volumes of red blood cell transfusion in preterm infants Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-24 Rong Chen, Shu-Hua Lai, Wen-Long Xiu, Wen-Hong Cai, Zhi-Qin Chen, Ying-Ling Xie
Objectives The purpose of this study was to investigate and compare the effects of 20 ml/kg and 15 ml/kg red blood cell transfusion (RBCT) on cerebral and intestinal tissue oxygenation, the number of administered transfusions, and neonatal complications in premature infants with anemia. Methods This prospective, randomized, partially blinded observational study investigated anemic neonates of gestational
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First report of successful treatment of chronic pediatric tibial osteomyelitis and fracture using autologous platelet-rich plasma Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-24 Kexuan Qu, Jianxiang Liu, Hao Chen, Lilan Gao, Shuxia Wang, Mengxing Lv
Osteomyelitis is a refractory disease caused by microbial invasion of the bone, leading to destruction of the bone tissue. It is more common in children. Osteomyelitis requires long treatment at high cost and is associated with high rates of recurrence and disability. It can also be complicated by sepsis that, if not treated in time, can result in death. Here, we report the first case of a 10-year-old
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The impact of diabetes mellitus on hematopoietic stem cell mobilization, a-single center cohort study Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-22 Serhat Çelik, Leylagül Kaynar, Zeynep Tuğba Güven, Nermin Keni Begendi, Fatma Demir, Muzaffer Keklik, Ali Ünal
Background Factors such as age, underlying hematological disease, chemotherapy and radiotherapy used, and bone marrow infiltration may cause mobilization failure. Several preclinical observed that diabetes mellitus (DM) leads to profound remodeling of the hematopoietic stem cell (HSC) niche, resulting in the impaired release of HSCs. We aim to examine the effect of DM on HSC mobilization and to investigate
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Evaluation of chemiluminescence immunoassay as a screening test for syphilis on blood donor samples Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-21 Cherry Gupta, Kshitija Mittal, Ravneet Kaur, Jasbinder Kaur, Tanvi Sood, Gagandeep Kaur, Paramjit Kaur
Background and objective Global re-emergence of syphilis among blood donors necessitates novel diagnostic and prevention approaches that encourage timely intervention. Thus, the present study was planned to evaluate the efficiency of Chemiluminescence immunoassay (CLIA) as a screening test for syphilis. Material and methods This prospective cross-sectional observational study was conducted from October
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Efficacy of therapeutic plasma exchange in pediatric cases of acute liver failure as an extracorporeal liver support system Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-21 Mohit Chowdhry, Ankita Sharma, Soma Agrawal, Rohit Vohra, Karunesh Kumar, Neerav Goyal, Arun Kumar V, Nameet Jerath, Smita Malhotra, Anupam Sibal, Manoj Mishra
Background Acute liver failure in the pediatric population is often accompanied by deranged metabolism, severe encephalopathy and coagulopathy. A liver transplant is the most viable option for the management of such patients. Therapeutic plasma exchange (TPE) is helpful in improving the liver biochemistry profile, thereby, increasing their likelihood of undergoing a liver transplant Method The study
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Anti-D alloimmunization by Asia type DEL red blood cell units in a D-negative Thai patient Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-20 Jairak Thongbut, Caroline Bénech, Niramon Phiri, Ploymanee Suwanwootichai, Chutarat Thongpao, Sasitorn Bejrachandra, Pawinee Kupatawintu, Dootchai Chaiwanichsiri, Yann Fichou
Background DEL phenotype is a rare Rh variant that cannot be detected by routine serological typing, and DEL individuals are thus typed D-negative (D–). Anti-D alloimmunization has been reported in “true” D– patients receiving DEL red blood cells (RBCs). Case presentation A 17-year-old, D– Thai male patient suffering from immunodeficiency syndrome with negative antibody screening received RBC units
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Overview on novel strategies and current guidelines for hematopoietic stem cell mobilisation and collection Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-12 F. Lanza, M. Marchetti, B.A. Zannetti
The success of the autologous stem cell transplantation is strictly related to an adequate hematopoietic stem cell mobilization and collection. The minimum threshold for a successful mobilization is currently defined as 2 × 106/kg CD34+ cells. However, the optimal stem cell mobilization strategy is still controversial. The availability of plerixafor, a selective and reversible CXCR4 inhibitor, has
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Overcoming challenges in managing a high-risk pregnancy with placenta previa and newly diagnosed Bombay phenotype Transfus. Apher. Sci. (IF 1.9) Pub Date : 2023-10-11 Tayler A. Van Denakker, Kathy Haddaway, Alyssa Cunningham, Karaleigh Leonard, Kristin Darwin, Monica Meeks, Shari M. Lawson, Arthur Vaught, Alison Moliterno, Steve M. Frank, Aaron Tobian, Elizabeth Crowe, Evan Bloch, Herleen Rai
Background Bombay phenotype is rare and characterized by a lack of H antigen on the surface of red blood cells (RBCs) with naturally occurring anti-H antibodies. The presence of anti-H necessitates the exclusive use of Bombay phenotype RBCs for transfusion. We present a case of a pregnant woman with Bombay phenotype who required urgent cesarean section delivery due to high-risk placenta previa. Case