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Evaluation of riboflavin concentrations and light intensities on bacteria reduction in platelets using visible light Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-09-18 Hong Liu, Qin Mo, Jianhao Yang, Yao Jia, Rongna Ma, Xiaofei Wu, Yuwen Huang, Xun Wang
Bacterial contamination in platelets has been a major concern over the years. In this study, we showed that treatment with 420 nm visible light with various concentrations of riboflavin in platelets reduced E. coli and S. aureus by 0–1.56 and 0.3–2.02 logs (50 mW/cm2), 2.24–4.77 and 0.73–3.26 logs (75 mW/cm2), and ≥ 5.14 and ≥ 5.27 logs (100 mW/cm2). Treatment with high-intensity light (100 mW/cm2)
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Enhancing clinical insight: Implementing validated questionnaires for comprehensive assessment of clinician expertise in transfusion medicine practices Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-09-16 Anubhav Gupta, Hari Krishan Dhawan, Romesh Jain, Ratti Ram Sharma, Vipin Kaushal, Amarjeet Singh, Neelam Marwaha
Blood transfusion is a cornerstone of modern healthcare, pivotal in saving countless lives annually. However, inadequate knowledge among healthcare providers can lead to serious complications. Despite the availability of assessment tools like the Biomedical Excellence for Safer Transfusion (BEST) test, there is a need for indigenous-validated questionnaires to address knowledge gaps effectively. This
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Does immunohistochemical staining predict mobilization success in multiple myeloma patients? Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-09-15 Fatma Keklik Karadag, Murat Aysin, Nur Soyer, Ajda Güneş, Denis Bozer, Derya Demir, Aysenur Arslan, Fahri Sahin, Mahmut Töbü, Guray Saydam, Filiz Vural
So many risk factors for mobilization failure have been described so far. We aimed to identify the risk factors and search the possible effects of bone marrow fibrosis (BMF), CD56, c-myc, and cyclinD1 expression on mobilization.
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The practical use of artificial intelligence in Transfusion Medicine and Apheresis Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-09-10 Celine Anstey, David Ullman, Leon Su, Chuying Su, Chad Siniard, Sierra Simmons, Jesse Edberg, Lance A. Williams III
Blood and plasma volume calculations are a daily part of practice for many Transfusion Medicine and Apheresis practitioners. Though many formulas exist, each facility may have their own modifications to consider. ChatGPT (Generative Pre-trained Transformer) provides a new and exciting pathway for those with no programming experience to create personalized programs to meet the demands of daily practice
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Cell throughput and performance ratio as quality indicators on hematopoietic stem cell apheresis: A single-center experience Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-09-10 Yandy Marx Castillo-Aleman, Carlos Agustin Villegas-Valverde, Antonio Alfonso Bencomo-Hernandez, Yendry Ventura-Carmenate, Shinnette Lumame, Charisma Castelo, Nameer Abdul Al-Saadawi, Mohamed Ibrahim Abu-Haleeqa, Inas El-Najjar, Fatema Mohammed Al-Kaabi
Benchmarking in CD34 cell apheresis is crucial for optimizing resources, ensuring consistent collection performance, and ultimately, decision-making algorithms to improve donor safety. Key performance indicators such as the “performance ratio” (PR) are applied routinely in some apheresis centers, whereas this report identifies the “cell throughput” (CT) as another quality indicator in apheresis. This
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Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-09-08 Arash Ahmadfard Moghadam, Amir Reza Manafzadeh, MR Nikoonia, Seyedeh Somayeh Moazezi, Khadijeh Dajliry Nekoei, Farahnaz Ramezan, Davood Bashash, Mohsen Hamidpour, Shadi Tabibian
One of the major problems for patients with severe hemophilia A (HA) is the development of neutralizing antibodies against factor VIII. This study aimed to analyze the molecular and clinical profiles of patients with severe HA and to determine if certain genetic variants predispose to inhibitor development in these patients.
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Considerations regarding the potential resurgence of transfusion-transmitted syphilis in the United States due to increasing disease incidence and use of fresh blood products Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-30 Brian D. Adkins, Jordan Keith, Jeremy W. Jacobs, Garrett S. Booth
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Corrigendum to “ACKR1 gene polymorphisms in Bombay blood group (Oh) individuals of Indian origin” [Transfus Apher Sci 63 (2024) 103975] Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-23 R. Shaikh, G. Kanjaksha, V. Kashivishwanath, S. Kulkarni, S. Jadhav, H. Maru, A. Gorakshakar
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Allogeneic serum-based eye drops may give better results than autologous drops in Sjögren's syndrome dry eye Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-21 Joanna Janus, Katarzyna Chmielewska, Jolanta Antoniewicz-Papis
Sjögren’s syndrome (SS) may cause severe dry eye symptoms. One of the therapeutic option known for almost 40 years are autologous serum eye drops (ASEDs). Due to the presence of many pro-inflammatory factors in the autologous serum of SS patients, the use of allogeneic serum is often considered a better option. In our facility almost one-fifth of the patients using allogeneic serum-based eye drops
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Treatment of acute and chronic graft-versus-host disease with extracorporeal photopheresis: Update of best practice recommendations from Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and the Italian Transplant Group for Bone Marrow Transplantation, Hematopoietic Stem Cells and Cell Therapy (GITMO) Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-13 Anna Colpo, Monia Marchetti, Irene Bianco, Fabio Cruciani, Francesco Ipsevich, Mauro Montanari, Maria Teresa Lupo Stanghellini, on behalf of the Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and the Italian Transplant Group for Bone Marrow Transplantation Hematopoietic Stem Cells and Cell Therapy (GITMO)
These guidelines represent a GRADE-method revision of the recommendations produced by the Italian Society of Hemapheresis and Cell Manipulation (SIDEM) and the Italian Transplant Group for Bone Marrow Transplantation, Hematopoietic Stem Cells and Cell Therapy (GITMO) in 2013. Since 2013 several studies have been published that have strengthened the role of ECP in the management of GVHD. Thus, it was
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Effects of continuous negative pressure suction combined with autologous platelet-rich gel on the levels of CRP, IL-6, wound healing and length of stay in clients with diabetic foot Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-10 Lan Zhang, Yuan Zhao, Xiaoyun Fan, Dongliang Liu, Yan Geng
Continuous passive pressure suction and APG gel therapy effect diabetic foot IL-6, CRP, wound healing, and hospitalization. Clinicopathological data from 102 diabetic foot ulcer patients treated at our institution between March 2018 and May 2022 was examined. Tables generated 51 joint and controlling teams randomly. The observation team received passive pressure suction and APG gel whereas the controlled
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Reflections on the current position and future trends in immunoglubulin therapy Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-09 Jerard Seghatchian
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Position paper on advancing sickle cell disease management in France by bridging the clinical practices and guidelines through expert insights Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-08 K. Benmoussa, F. Bernaudin, P. Connes, O. Héquet, L. Joseph, M. Beraud, A. Bah
In France, sickle cell disease (SCD) is the most common rare disease and represents the most prevalent genetic disorder, with 19,800 to 32,400 patients diagnosed in 2016 and 1:714 newborns affected in 2019. SCD is caused by a single mutation in the β-globin gene, resulting in the production of abnormal hemoglobin (called HbS), chronic hemolytic anemia, and impaired red blood cell rheology. SCD patients
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Towards personalized and rational use of immunoglobulins amid expanding indications and shortages Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-08 Hadi Goubran, Gaafar Ragab, Jerard Seghatchian, Thierry Burnouf
The development of intravenous IgG (IVIG) formulations in the 1970s enabled expanded use for treating primary antibody deficiency syndromes and autoimmune conditions. Recent advancements include the use of IVIG in secondary immune deficiencies related to hematologic malignancies and stem cell transplantation, along with the newly emerging prophylactic applications following chimeric antigen receptor
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Development of Safe Blood Transfusion Self‐Efficacy Scale for nurses: Validity and reliability study Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-08 Gülsüm Dülger, Gülten Karahan Okuroglu
The aim of the study is to develop a scale to measure nurses' self-efficacy levels regarding safe blood transfusion practice. This study, applied in methodological design, was conducted in a public university hospital in Istanbul between March-April 2021. The sample included 372 nurses. A draft form consisting of 75 items was prepared. Content validity, construct validity, distinctiveness, internal
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Analysis of apheresis outcomes in a cohort of Chilean patients treated with autologous stem cell transplantation: A single center real-world experience Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-08-02 M Sarmiento, J Salinas, P Rojas, C Gutierrez, M Vidal, V Jara, MJ Garcia, MJ Campbell, Y Flores, V Sandoval, M Vergara, F Palacios, M Ocqueteau
Adequate stem cell harvesting is required for autologous hematopoietic transplantation. In deficient mobilizer patients, the collection of stem cells can be challenging because of the impossibility of achieving satisfactory CD34 cell counts with GCSF + - chemotherapy. Plerixafor is a potent and expensive drug that promotes the release of stem cells from the medullary niche to the peripheral blood and
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ACKR1 gene polymorphisms in Bombay blood group (Oh) individuals of Indian origin Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-25 Roshan Shaikh, Ghosh Kanjaksha, Vasantha Kashivishwanath, Swati Kulkarni, Seema Jadhav, Harita Maru, Ajit Gorakshakar
ACKR1 blood group genes exhibit a high degree of polymorphisms with varying allele distribution seen among different populations and ethnic groups. The study aimed to genotype ACKR1 antigens and to establish FY allele frequency among the individuals with the Bombay (Oh) blood group phenotype. ACKR1 phenotype and genotype frequencies were estimated on 160 individuals typed as Oh and were compared with
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A Chinese individual with DEL phenotype caused by a novel RHD allele Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-23 Fan Wu, Ya-dan Luo, Shuang Liang, Li-yan Sun, Tong Liu, Yan-lian Liang, Yu-qing Su
RhD variants are categorized into partial D, weak D, and DEL. The detection of DEL can only be achieved through the adsorption and elution method or molecular techniques. Here, we report a case of DEL phenotypes associated with a novel allele in a Chinese individual. We used serological methods such as saline, indirect anti-human globulin, and adsorption-elution. The genotype was determined by the
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Breast milk induced immune haemolytic disease of newborn due to anti-c: A case report Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-22 Aarushi Sahni, Vasanthakumar Karumannan, Lakhvinder Singh, Richa Jain, Ratti Ram Sharma
Hemolytic disease of fetus and newborn is a major risk factor for anemia and hyperbilirubinemia in newborns. Early identification and diagnosis can significantly improve neonatal health. This report documents a case of hemolytic disease of fetus and newborn presenting as persistent neonatal anemia requiring frequent transfusion support. The underlying cause was determined to be the passive acquisition
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18th Congress of the World Apheresis Association Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-03 Iryna Tykhonenko
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Recombinant human thrombopoietin improves platelet engraftment after autologous hematopoietic stem cell transplantation in patients with aggressive lymphoma Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-02 Xi Qiu, Huawei Jiang, Xibin Xiao, Liansheng Huang, Yang Xu
To explore the efficiency and safety of recombinant human thrombopoietin (TPO) on the platelet engraftment after autologous stem cell transplantation (ASCT) in patients with aggressive lymphoma. Forty patients were enrolled in a single-center, retrospective clinical trial from July 2019 with rhTPO administration when the platelet count ≤ 75 × 10/L after the reinfusion of stem cells. The hematopoietic
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Insight into hazards and control of transfusion-transmitted infections in Egypt: A narrative review Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-02 Hazem A. Sayed Ahmed, Noha Kamel, Eman Mohamed Mahfouz
Blood transfusion is a critical life-saving medical intervention, but it carries the risk of transfusion-transmitted infections (TTIs) that can lead to serious consequences. TTIs include viral, bacterial, parasitic, and prion infections, transmitted through asymptomatic donor blood, contamination of stored blood products, or transfusion-related immunosuppression. Recognized global agents posing challenges
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Evaluation of transfusion reactions in patients following transfusion of blood components containing antibodies to HLA class I – An attempt to prevent TRALI in patients Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-02 Nhan T. Nguyen, Thomas Larsen Titze, Lise Sofie H. Nissen-Meyer
In an attempt to mitigate transfusion-related acute lung injury (TRALI), the Oslo Blood Center screened 1369 thrombapheresis donors for human leucocyte antigen (HLA)-specific antibodies. Anti-HLA antibodies were found in 200 donors who were deferred from donation of plasma-rich products. In a retrospective study, 2562 transfusions of thrombocytes (both apheresis and whole blood-derived) from 150 of
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Why do RhD negative pregnant women still become anti-D immunized despite prophylaxis with anti-D immunoglobulin? Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-02 Çiğdem Akalın Akkök
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Editorial comments: Two clinical viewpoints from Oslo Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-02 Jerard Seghatchian
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Immunological and therapeutic insights in autoimmune autonomic ganglionopathy: What is the position of apheresis in immunotherapy? Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-07-02 Shunya Nakane, Hidenori Matsuo, Yuji Nakatsuji
Autoimmune autonomic ganglionopathy (AAG) is characterized by various autonomic and extra-autonomic symptoms and is caused by autoantibodies against nicotinic acetylcholine receptors present in the autonomic ganglia (ganglionic acetylcholine receptor, gAChR), requiring immediate and aggressive intervention to prevent the exacerbation of symptoms. However, there is currently no internationally accepted
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The effect of agitating buffy coats on platelet quality before soft spin Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-30 Shichun Wang, Qi Liu, Ronghua Diao, Zerong Wang, Yahan Fan, Shuguang Liu, Jie Liu, Shuming Zhao, Chunyan Yao
Platelet plays a vital role in both physiological and pathological processes. However, the limited storage time of platelet poses an immense challenge for its applications because of the increased risk of bacterial contamination and platelet storage lesions. Agitation can inhibit lesions by facilitating continuous oxygenation of platelets and permitting excess carbon dioxide to be removed during storage
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Bacterial species in cord blood and their significance in the context of clinical use Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-29 Helena Barreto Henriksson, Ann Hellström, Anders K. Nilsson, Ulrika Sjöbom, Bodil Jönsson, Sofia Frändberg
Approximately 90 % of infants born before 28 full weeks(extremely-preterm-infants) receive erythrocyte transfusions in early life. Umbilical cord blood(UCB) has been investigated as an alternative source for erythrocyte transfusions to preterm neonates. This retrospective study aimed to compile/evaluate spectrum of bacteria groups/species intermittently detected in processed UCB at National-Swedish-Cord
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Irregular red blood cell antibodies, abnormal hemoglobin and dangerous universal blood donor insights from a public blood center in a Brazilian metropolitan area Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-21 Laiane da Silva Santos, Sérgio Eduardo Soares Fernandes, Anna Luiza Oliveira Sant’Anna, Flávio Ferreira Pontes Amorim, Felipe Ferreira Pontes Amorim, Fábio Ferreira Amorim
Immunohematology tests are crucial in transfusion safety. This study aimed to assess irregular red blood cell (RBC) antibodies, abnormal hemoglobin and dangerous universal blood donors at a public blood center in a Brazilian metropolitan area. A cross-sectional study included all consecutive blood donors from January 2018 to December 2021 at the Brasília Blood Center Foundation, Federal District (FD)
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Genotype-phenotype analyses of Iranian patients with hemophilia B (Leyden -) and hemophilia B (Leyden +): A single-center study Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-20 Arash Ahmadfard Moghadam, Amir Reza Manafzadeh, Khadijeh Dajliry, Farahnaz Ramezan, Mohammad Reza Nikoonia, Babak Abdolkarimi, Mohsen Hamidpour, Shadi Tabibian
There is a high prevalence of inherited bleeding disorders in Iran, such as hemophilia A (HA) and hemophilia B (HB). This study aimed to analyze the molecular and clinical profiles of patients with HB. A single-center study was conducted among patients with severe HB between March 20, 2000, and June 31, 2023. The polymerase chain reaction (PCR) amplification was used for all of the major regions, such
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The use of therapeutic plasma exchange in systemic loxoscelism induced treatment resistant hemolytic anemia: A case report Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-14 Joshua Mehr, Jaehyup Kim
Brown recluse spider bites can lead to severe reactions such as skin necrosis,hemolytic anemia, and multiorgan failure, which can be life-threatening. Therapeutic plasma exchange has been reported to provide clinical benefit for such cases. In thisreport, we present a case of a brown recluse spider bite that was successfully treated with therapeutic plasma exchange and compare it with previous case
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Analysis of erythrocyte and iron study data among plateletpheresis donors in Hangzhou, China Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-12 Chunyan Li, Zhongxiu Wu, Beijie Guo, Ruohua Ba, Haiyan Yang, Yinhong Zheng
The purpose of this study is to obtain the iron parameters level of blood donors and the population who need to pay attention to iron parameters level in this area. A total of 993 plateletpheresis donors were included in this study, including 798 males and 195 females. The results of erythrocyte and iron parameters of blood donors were compared and analyzed in different groups according to the gender
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Severe amlodipine toxicity: A medical dilemma managed with therapeutic plasma exchange Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-06-05 Dilna Christy Edison, Joseph Philip, R.S. Mallhi, Ritika Basnotra, Vineeth Pynadath, Kalyani Sane
Amlodipine poisoning is a nightmare for treating clinicians because of the intractable hypotension and bradycardia induced by the drug, which requires a balanced treatment algorithm. We encountered a case of severe Amlodipine toxicity (450 mg) who presented with complaints of nausea, multiple episodes of vomiting, and chest discomfort. On arrival at the EMD, the patient had significant hypotension
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The prevalence of alloantibodies and ABO RhD blood groups in a cohort of Aboriginal and non-Aboriginal cardiac surgery patients from Australia Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-05-29 Romi Sinha, Robert A. Baker, Tina Noutsos, Maree Perry, David Roxby
Limited evidence exists on the distribution of ABO RhD blood groups and prevalence and specificity of red blood cell (RBC) alloantibodies in Aboriginal and Torres Strait Islander peoples of Australia. We investigated RBC alloantibody prevalence and ABO RhD groups in Aboriginal patients undergoing cardiac surgery at a South Australian (SA) tertiary hospital, a major cardiac surgical referral centre
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Is an earlier strategy for harvesting peripheral blood stem cells in healthy allogeneic donors feasible? Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-05-27 Samet Yaman, Ersin Bozan, Sema Seçilmiş, Burcu Aslan Candır, Ali Kılınç, Semih Başcı, Tuğçe Nur Yiğenoğlu, Merih Kızıl Çakar, Mehmet Sinan Dal, Fevzi Altuntaş
Peripheral blood stem cells (PBSC) mobilization with granulocyte colony stimulating factor (G-CSF) for healthy donors is generally performed at 5th day. However, earlier collection is sometimes feasible, raising the question of whether to initiate apheresis early to limit further G-CSF exposure, while considering the risk of mobilization failure. In the current study, we examined the factors predicting
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Alterations in trace elements and cation profiles in transfusion-dependent thalassemia patients Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-05-25 Maha Abdul Saheb Ridha, Mohammed K. Kahlol, Hussein Kadhem Al-Hakeim
Transfusion-dependent thalassemia (TDT) is a severe form of beta-thalassemia, characterized by defective-globin production, resulting in a buildup of unpaired alpha globin chains. Patients with TDT can only survive if they receive safe blood transfusions regularly, which causes iron overload in their blood, which causes a variety of disorders. Cations and trace elements in TDT patients as a drug target
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Challenges in organising blood donation camps at remote military base and its impact on blood component quality: A unique helicopter-based whole blood transport experience Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-05-21 Vasanth Asirvatham, Anubhav Gupta, Davood Bava, Parmatma Prasad Tripathi, Siddharth Mittal
There is a huge gap between safe blood supply and clinical demand in India and voluntary blood donation camps (BDSs) are vital to address this gap. The study evaluates the challenges faced in organizing remote setting voluntary BDCs and assess the impact of helicopter-flight on the quality of the whole blood units (WBU) and blood components (BC) prepared. This is an observational study in which two
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Transfusion outcomes and clinical safety of ABO-nonidentical platelets transfusion: A systematic review and meta-analysis Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-05-20 Zhanrui Cheng, Yujie Kong, Yuwei Lin, Ziyue Mi, Ling Xiao, Zhong Liu, Li Tian
ABO-nonidentical platelets transfusion has been frequently employed to address clinical platelets insufficiencies. The significance of ABO compatibility for platelets transfusion is not clearly defined. This study is aimed to explore the transfusion outcomes and clinical safety of ABO-nonidentical platelets transfusion. A systematic articles search was performed for eligible studies published up to
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Impact on cytokine accumulation in 35-day preserved whole blood due to resin adsorption Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-05-17 Shifang Yu, Gang Deng, Qiang Li, Zhaoping Liao, Lu Yu, Xiaoying Zhao
Blood transfusion in critically ill individuals such as sepsis was associated with higher morbidity and mortality. During storage, various bioactive substances accumulated, may exacerbate the initial immunosuppressive reaction in severely ill patients. The objective of this study is to explore how resin adsorption impacts the accumulation of cytokines and the presence of extracellular microvesicles
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Gynecological bleeding in women with congenital bleeding disorders: A comprehensive cohort from Iran Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-30 Alireza Zafarani, Elnaz Ghodratnia, Mohammad Reza Amirzargar, Yasaman Poriafar, Shadi Tabibian
Gynecological bleeding including menorrhagia and postpartum hemorrhage (PPH) face women's quality of life constantly with difficulties, especially those suffering from inherited bleeding disorders. In this study, we aim to evaluate gynecological bleeding particularly menorrhagia among Iranian women patients with inherited bleeding disorders admitted to the Iranian Comprehensive Hemophilia Care Center
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Effect of apheresis plasma donation on plasma uric acid levels, the lipid profile, and major plasma proteins in plasma donors in China: A multicenter, prospective cohort study Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-29 Qing Liu, Fengjuan Liu, Pan Sun, Xi Du, Liyuan Zhu, Jun Xu, Lu Cheng, Yaojing Huang, Chunyan Huang, Jielin Chen, Zhibo Wang, Aihong Lu, Yikuan Zhu, Huan Huang, Junli Huang, Jufeng Pan, Li Ma, Zongkui Wang, Changqing Li
Abnormal plasma uric acid (UA) levels, the lipid profile, and plasma proteins in blood are associated with a range of adverse health outcomes. This multicenter, prospective cohort study aimed to determine the possible effects of multiple apheresis plasma donations on plasma UA levels, the lipid profile, and major proteins in plasma donors. Participants were enrolled from 1 April 2021 to 31 August 2022
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Successful treatment of concurrent cold agglutinin disease and myelodysplastic syndrome Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-25 Rie Tabata, Chiharu Tabata
Herein, we describe a case of severe anemia presenting with myelodysplastic syndrome with cold agglutinin disease that was successfully treated by a moderate dose of steroids followed by cyclosporine. In patients with myelodysplastic syndrome, autoimmunity in erythroid cells is occasionally demonstrated, and autoimmune hemolytic anemia is seen in some patients. However, hemolytic anemia with cold agglutinin
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Serology and molecular genetic analysis of two unrelated individuals with the same novel CisAB blood type Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-25 Tongtong Li, Yongqiang Shan, Xinhua Zhou, Ying Zhao, Lina Wu, Xian Huang, Yang Yang, Jinhui Xie, Jinghui Chong
This study aims to report two unrelated individuals with the same novel CisAB blood type and confirm this rare blood type using a comprehensive approach that combines serological and molecular biology techniques. Peripheral blood samples were collected from two patients and their family members. ABO blood typing and antibody detection were performed using conventional tube methods. Molecular biology
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Determination of optimum levels of binding antibody units (BAU) of new quantitative chemiluminescent immuno-assay (CLIA) in COVID-19 vaccinated volunteer blood donors Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-24 Aseem Kumar Tiwari, Geet Aggarwal, Pratibha Kale, Neeti Yadav, Virendra Kumar, Gargi Singh, K. Cheirmaraj, K. Krishnan
For assessment of COVID-19 vaccine efficacy, neutralization activity of anti-SARS-CoV-2 antibody is measured. This study was undertaken to determine optimum levels of binding antibody units (BAU/ml) in new quantitative chemiluminescent assay (CLIA) that corresponded to neutralizing potential (30% inhibition) of sVNT assay. Methods: Ninety-one blood samples were analyzed by CLIA and sVNT assays. Test
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Focus on: Prognostic scores to predict stem cell mobilization Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-23 Attilio Olivieri, Francesco Saraceni, Amalia De Luca
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Outpatient hospitalist-run procedure service bridges the gap in oncology care Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-21 Ghadi Ghanem, Hsin Hsiang Clarence Tsai, Catherine Durant, Gary S. Feigenbaum, Alexandra Milin Glaeser
Hospitalist-run procedure teams enable expedited care in the inpatient setting. However, wait times for outpatient interventional radiology (IR) are long at our institution. Our study thus aims to compare the safety and wait times between procedural teams and IR placement of outpatient temporary hemodialysis catheters (THDC) for patients undergoing Chimeric antigen receptor T-cell (CAR-T) therapy apheresis
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Novel approaches for hematopoietic stem cell mobilisation and collection need to be assessed for qualification and validation to accomplish the proper requirements of their intended purpose Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-20 Francesco Lanza, Giovanni Marconi
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How to manage poor mobilisers Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-18 Nina Worel
Autologous hematopoietic progenitor cell transplantation (ASCT) has been used for more than five decades to treat malignant and non-malignant diseases. Successful engraftment after high-dose chemotherapy relies on the ability to collect sufficient CD34 + hematopoietic progenitor cells (HPCs), typically from peripheral blood after mobilization. Commonly, either granulocyte colony-stimulating factor
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Editorial comments: Looking for some innovative diagnostic or developmental research studies that might influence our laboratory and clinical decision-making Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-18 Jerard Seghatchian
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Platelet function testing: Update on determinant variables and permissive windows using a platelet-count-based device Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-18 Patricia Villar, Sofía Carreño, Sara Moro, Inés Díez Galindo, Ángel Bernardo, Laura Gutiérrez
While there are various aspects of platelet biology that can be studied in the lab ( adhesion, degranulation, integrin activation), the master test for platelet function is that which gives a measure of the platelet aggregation capacity upon stimulation with an agonist. Platelet function testing is necessary for the diagnosis of platelet disorders and the monitoring of patients receiving anti-platelet
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A perspective on exogenous redox regulation mediated by transfused RBCs subject to the storage lesion Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-18 Nishaka William, Jason P. Acker
Granted with a potent ability to interact with and tolerate oxidative stressors, RBCs scavenge most reactive oxygen and nitrogen species (RONS) generated in circulation. This essential non-canonical function, however, renders RBCs susceptible to damage when vascular RONS are generated in excess, making vascular redox imbalance a common etiology of anemia, and thus a common indication for transfusion
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Impact of ABO blood group on mortality in trauma patients: A systematic review Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-18 Andrew Follows, Antonia Round
Haemorrhage is a significant cause of death in trauma patients. There is evidence that individuals with blood group O have higher rates of non-traumatic haemorrhage. It has been suggested that blood group O may be associated with higher mortality in trauma, however existing evidence is limited and conflicting. A systematic review was conducted to evaluate the impact of ABO blood group on mortality
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Graft collection by apheresis and graft composition Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-17 Luca Pierelli, Anna Capalbo
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Mobilization and collection of CD34 + cells in patients with globin disorders: Providing the starting material to manufacturers of autologous gene therapies Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-17 Christian Chabannon, Sandrine Visentin, Angéla Granata, Isabelle Thuret
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Advancing in vivo assessment of red blood cell transfusions: A call for radiation-free methods in transfusion medicine Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-17 Mahsa Yazdanbakhsh, Jason P. Acker
RBC transfusions are a vital clinical therapy to treat anemic patients. The assessment of red blood cell (RBC) quality post-transfusion is critical to ensuring that the introduction of new RBC products meet established regulatory and clinical quality requirements. Although quality control testing is routinely performed by blood manufacturers, it is crucial that tests are performed during the evaluation
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Prevalence and factors influencing anemia recovery after intensive care Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-16 Kyoung Won Yoon, Sungjoo Park, Chi-Min Park
Anemia is associated with adverse outcomes and prolonged hospitalizations in critically ill patients. Regarding the recent adoption of restrictive transfusion protocols in intensive care unit (ICU) management, anemia remains highly prevalent even after ICU discharge. This study aimed to investigate the prevalence of anemia following ICU discharge and factors affecting recovery from anemia. In this
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Impact of cell salvage on hematocrit and post-partum anemia in low hemorrhage risk elective cesarean delivery Transfus. Apher. Sci. (IF 1.4) Pub Date : 2024-04-16 Daniel Katz, Annalin Griffel, Sarah Granozio, Gary Koenig, Hung-Mo Lin
Postpartum anemia is a significant contributor to peripartum morbidity. The utilization of cell salvage in low risk cases and its impact on postpartum anemia has not been investigated. We therefore aimed to examine the impact of autologous blood transfusion/cell salvage in routine cesarean delivery on postoperative hematocrit and anemia. Retrospective cohort study from a perfusion database from a large