Granted with a potent ability to interact with and tolerate oxidative stressors, RBCs scavenge most reactive oxygen and nitrogen species (RONS) generated in circulation. This essential non-canonical function, however, renders RBCs susceptible to damage when vascular RONS are generated in excess, making vascular redox imbalance a common etiology of anemia, and thus a common indication for transfusion. This accentuates the relevance of impairments in redox metabolism during hypothermic storage, as the exposure to chronic oxidative stressors upon transfusion could be exceedingly deleterious to stored RBCs. Herein, we review the prominent mechanisms of the hypothermic storage lesion that alter the ability of RBCs to scavenge exogenous RONS as well as the associated clinical relevance.

中文翻译：

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受储存损伤影响的输注红细胞介导的外源性氧化还原调节的观点


红细胞具有与氧化应激源相互作用并耐受氧化应激源的强大能力，可清除循环中产生的大多数活性氧和氮物种 (RONS)。然而，当血管 RONS 生成过多时，这种重要的非典型功能使红细胞容易受到损害，从而使血管氧化还原失衡成为贫血的常见病因，从而成为输血的常见指征。这凸显了低温储存期间氧化还原代谢受损的相关性，因为输血时暴露于慢性氧化应激源可能对储存的红细胞极其有害。在此，我们回顾了低温储存损伤改变红细胞清除外源性 RONS 能力的重要机制以及相关的临床相关性。