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A review of the mesotheliogenic potency of cleavage fragments found in talc Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-04-15 E Miller, EM Beckett, D Cheatham, CE Comerford, RC Lewis, C Krevanko, N Mandava, JS Pierce
It has long been recognized that amphibole minerals, such as cleavage fragments of tremolite and anthophyllite, may exist in some talc deposits. We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology
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Assessment of genotoxicity biomarkers in gasoline station attendants due to occupational exposure Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-04-10 Aylin Elkama, Kerem Şentürk, Bensu Karahalil
Gasoline station attendants are exposed to numerous chemicals that might have genotoxic and carcinogenic potential, such as benzene in fuel vapor and particulate matter and polycyclic aromatic hydrocarbons in vehicle exhaust emission. According to IARC, benzene and diesel particulates are Group 1 human carcinogens, and gasoline has been classified as Group 2A “possibly carcinogenic to humans.” At gas
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Ascorbic acid attenuates gasoline-induced testicular toxicity, sperm quality deterioration, and testosterone imbalance in rats Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-04-10 Ogechukwu E Ezim, Joy Nyeche, Chisom E Nebeolisa, Chuka D Belonwu, Sunny O Abarikwu
The present study evaluated the protective effect of ascorbic acid (ASCB) against gasoline fumes (PET) induced testicular oxidative stress, sperm toxicity, and testosterone imbalance in Wistar rats. Twenty-four (24) male albino rats (75 ± 16 g) were randomized into three experimental groups ( N = 8). The control group: received normal saline, PET group: exposed to PET 6 h daily by inhalation in an
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Gender associations between phthalate exposure and biomarkers of oxidative stress: A prospective cohort study Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-04-09 Jian-Qing Wang, Zhi-Juan Li, Hui Gao, Jie Sheng, Chun-Mei Liang, Ya-Bin Hu, Xun Xia, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao, Fang-Biao Tao
Previous epidemiologic research has shown that phthalate exposure in pregnant women is related to adverse birth outcomes in a sex-specific manner. However, the biological mechanism of phthalate exposure that causes these birth outcomes remains poorly defined. In this research, we investigated the association between phthalate exposure and placental oxidative stress in a large population-based cohort
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Occurrence of alkyl glucosides in rinse-off cosmetics marketed as hypoallergenic or for sensitive skin Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-04-04 Dejan Ćirin, Jovana Milutinov, Veljko Krstonošić
Rinse-off cosmetic products, primarily shampoos, are frequently implicated in the onset of allergic contact dermatitis (ACD) caused by alkyl glucosides (AGs). AGs are increasingly popular surfactants and known contact allergens. Glucoside-induced ACD was most frequently observed with shampoos and skin-cleansing products in both consumer and occupational settings. Thereby, studies have shown that atopic
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Health risk assessment and prevalence of work-related musculoskeletal disorders among the aged brick molders, in India Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-04-03 Banibrata Das
The Brickfield Industry is the major and oldest informal industry in India, where millions of brickfield workers make their livelihood. Aged brickfield workers are also involved in different activities in the brickfield, especially in brick mold activities owing to poor socioeconomic conditions. A cross-sectional study was designed to determine the prevalence of work-related musculoskeletal disorders
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Assessment of the mode of action of perchloroethylene-induced mouse liver tumors Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-03-25 James E Klaunig, Christopher Bevan, Bhaskar Gollapudi
Perchloroethylene (PCE) is used as a solvent and chemical intermediate. Following chronic inhalation exposure, PCE selectively induced liver tumors in mice. Understanding the mode of action (MOA) for PCE carcinogenesis in mice is important in defining its possible human cancer risk. The proposed MOA is based on the extensive examination of the peer-reviewed studies that have assessed the mouse liver
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Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792) Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-03-22 Priyatha Chokki Veettil, Jeena Nikarthil Sidhick, Sajeela Kavungal Abdulkhader, Siva Prasad MS, Chitra Kumari Chidambaran
Triclosan (TCS), an antimicrobial drug, is known to occupy different compartments in aquatic ecosystems. The present study focused to evaluate the reproductive toxicity of triclosan, at environmentally relevant (0.009 and 9 μg L−1) and sublethal (176.7 μg L−1) concentrations for 90 days in the pre-spawning phase of the fish, Anabas testudineus. The reproductive biomarkers, namely, gonadal steroidogenic
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Manganese dioxide nanoparticles provoke inflammatory damage in BV2 microglial cells via increasing reactive oxygen species to activate the p38 MAPK pathway Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-03-22 Xingchang Sun, Xin Qin, Gaofeng Liang, Xuhong Chang, Huike Zhu, Jiahao Zhang, Dan Zhang, Yingbiao Sun, Sanwei Feng
With the widespread use of manganese dioxide nanoparticles (nano MnO2), health hazards have also emerged. The inflammatory damage of brain tissues could result from nano MnO2, in which the underlying mechanism is still unclear. During this study, we aimed to investigate the role of ROS-mediated p38 MAPK pathway in nano MnO2-induced inflammatory response in BV2 microglial cells. The inflammatory injury
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Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-03-12 Gül Kaplan, Merih Beler, Ismail Ünal, Atakan Karagöz, Gizem Eğilmezer, Ünsal Veli Üstündağ, Derya Cansız, A Ata Alturfan, Ebru Emekli-Alturfan
Exposure of zebrafish embryos to glucose is a suitable model for the fetal hyperglycemia seen in gestational diabetes. Diethylhexyl phthalate (DEHP), which is considered an endocrine-disrupting chemical, is one of the most common phthalate derivatives used in stretching plastic and is encountered in every area where plastic is used in daily life. In the present study, the effects of DEHP on pathways
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Semi-quantitative health risk assessment of heavy metal dust exposure among nail technicians using the SQRA technique and Monte Carlo simulation Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-02-20 Sara Karimi Zeverdegani, Zohreh Mohebian, Farzaneh Mohammadi, Leila Tajik
Nail technology, including the application of artificial nails and nail care, is a developing sector of the global beauty industry. Nail technicians are exposed to a variety of chemical substances through inhalation, as they spend extended periods of time in close proximity to these materials. This study aimed to evaluate the semi-quantitative health risk of dust-containing heavy metals among nail
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Noise and silver nanoparticles induce hepatotoxicity via CYP450/NF-Kappa B 2 and p53 signaling pathways in a rat model Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-02-15 Marzieh Belji Kangarlou, Ali Khavanin, Farshad Nadri, Zahra Goodarzi, Esmaeil Karami, Ali Rashidy-Pour, Mehrafarin Kiani, Raheleh Hashemi Habybabady
Co-exposure to noise and nanomaterials, such as silver nanoparticles (Silver-NPs), is a common occurrence in today’s industries. This study aimed to investigate the effects of exposure to noise and the administration of silver-NPs on the liver tissue of rats. Thirty-six adult male albino Wistar rats were randomly divided into six groups: a control group (administered saline intraperitoneally), two
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A biochemical and histological evaluation of in vivo exposure of bisphenol P for multi-organ toxicity and pathology in rats Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-02-13 Saadia Sattar, Asif Nadeem, Wasim Shehzad, Habib ur Rehman, Maryam Javed
Bisphenol P (BPP) is a structural analog of bisphenol A (BPA) and is increasingly used as a substitute of BPA in commercial and household applications. In recent years, BPP has been frequently detected in terrestrial and aquatic ecosystems. Very little epidemiological and experimental information are available on the toxicity potential of BPP in human and animal systems, which is very concerning in
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Stone mining work and dust pollution in Birbhum district, West Bengal, India Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-02-13 Biswanath Malakar, Subrata K Roy, Monohar Hossain Mondal, Ankit Roy
Dust pollution is common in Indian roads and several industrial settings (including mines) that affects human health. Identification and characterization of the dust particles in the mining area is essential for knowing the properties of the dust that effectively causes ailments to humans, particularly among workers those who are working in unorganized industrial settings. The present study aimed to
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Evaluation on purine metabolism in human skin fibroblast cells exposed to oxygenated polycyclic aromatic hydrocarbons Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-02-13 Junqi Liu, Saijin Wang, Meng Wang, Zan Li, Shi Zhou, Jinlian Li, Dongmei Wu
A rapid and sensitive assessment of the toxicity of oxygenated polycyclic aromatic hydrocarbons (OPAHs), widely distributed persistent organic pollutants in the environment, is crucial for human health. In this study, using high-performance liquid chromatography, the separation and detection of four purines, xanthine (X), guanine (G), adenine (A), and hypoxanthine (HX) in cells were performed. The
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Serum levels of inflammatory cytokines in mercury mining workers in a precarious situation: A preliminary study Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-30 Kelvin Saldaña-Villanueva, Ana K González-Palomo, Karen B Méndez-Rodríguez, Arturo Gavilán-García, Gamaliel Benítez-Arvizu, Fernando Diaz-Barriga, Luz Alcantara-Quintana, Francisco J Pérez-Vázquez
Mercury is a ubiquitous environmental xenobiotic; the primary sources of exposure to this metal are artisanal gold mining and the direct production of mercury. In Mexico, artisanal mercury mining continues to be an important activity in different regions of the country. Exposure to mercury vapors releases can have severe health impacts, including immunotoxic effects such as alterations in cytokine
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Dibutyl phthalate adsorbed on multi-walled carbon nanotubes can aggravate liver injury in mice via the Jak2/STAT3 pathway Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-29 Suli He, Chao Yan, Min Wu, Haiyan Peng, Ren Li, Jian Wan, Xin Ye, Hongmao Zhang, Shumao Ding
Phthalic acid esters (PAEs) and carbon nanotubes (CNTs) are common environmental pollutants and may degrade differently with different resulting biotoxicity, when present together. This study investigated the toxicological effects of singular or combined exposure to dibutyl phthalate (DBP) and multi-walled carbon nanotubes (MWCNTs) in KM mice. Results indicated that combined exposure led to slower
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Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-29 Weihuan Hu, Zheng Jin, Huihua Wang, Fangfang Wang, Fan Qu
Phthalates (PAEs), a group of environmental endocrine disruptors, are associated with oxidative stress and have adverse effects on female ovarian reserves. However, this association has been poorly investigated, particularly with respect to clinical evidence. In this study, we provided clinical evidence of a relationship between exposure levels of PAEs, oxidative stress and decreased ovarian reserve
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Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-24 Mohaddeseh Sadat Alavi, Elham Asadpour, Mohammad Taher Boroushaki, Omid Fakharzadeh Moghadam, Hamid R Sadeghnia
During recent decades, the application of zirconium dioxide nanoparticles (ZrO2-NP) has been expanded in various fields ranging from medicine to industry. It has been shown that ZrO2-NP has the potential to cross the blood–brain barrier (BBB) and induce neurotoxicity. In the current study, we investigated the in vivo neurotoxicity, as well as, the cellular mechanism of ZrO2-NP toxicity on two neuronal-like
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Toxicity evaluation of silver nanoparticles synthesized from naringin flavonoid on human promyelocytic leukemic cells and human blood cells Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-20 Deepika Soni, Deepa Gandhi
Increasing applications of silver nanoparticles (AgNPs) in multiple products like cosmetics, medicines, drugs, paints, and other new materials have raised concern for their toxic effects on living beings and the surrounding environment. In the present study, cytotoxicity and genotoxicity of AgNPs synthesized using plant flavonoid (Naringin) as a reducing agent were investigated on human promyelocytic
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Evaluation and risk communication of the effects of alcohol exposure on disposable procedure masks and portable air purifiers in hospital environments Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-16 Yo Ishigaki, Shinji Yokogawa, Tatsuo Kato
Electret technology was widely used to prevent the airborne transmission of bioaerosols during the COVID-19 pandemic and improve the filtration efficiency of masks and high-efficiency particulate air (HEPA) filters. As alcohol disinfectants are widely used in medical and welfare institutions, concerns about alcohol exposure inactivating electret exist. However, comprehensive alcohol exposure tests
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Assessing potential human health and ecological implications of PFAS from leave-in dental products Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-04 Andrey Massarsky, Jillian A Parker, Lauren Gloekler, Melinda T Donnell, Natalie R Binczewski, Jordan S Kozal, Taryn McKnight, Andrew Patterson, Marisa L Kreider
Contaminated water and food are the main sources of documented per- and polyfluoroalkyl substances (PFAS) exposure in humans. However, other sources may contribute to the overall PFAS intake. While several studies documented the presence of PFAS in consumer products, PFAS evaluation in dental products has been limited to floss and tape to date. This study estimated PFAS exposures from a convenience
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Risk assessment—based verification of the CertiPURTM limit values for toluene diamine and methylene dianiline in flexible polyurethane foam Toxicol. Ind. Health (IF 1.9) Pub Date : 2024-01-03 Patrick de Kort, Elke Jensen, Mark W Spence, Patrick M Plehiers
Flexible polyurethane foams (PUF) are used in many consumer products. PUF may contain trace levels of aromatic diamine impurities that could represent a potential health risk. The risk associated with sleeping on a PUF mattress was evaluated. Toxicity benchmarks for sensitization and non-cancer endpoints were derived from the respective points-of-departure using standard assessment factors. For the
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Clinical case analysis of 32 children aged 0-6 years with lead poisoning in Nanning, China. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-11-20 Yi-Fei Wei,Cui-Liu Gan,Fang Xu,Yuan-Yuan Fang,Bao-Dan Zhang,Wu-Shu Li,Kang Nong,Aschner Michael,Yue-Ming Jiang
Lead is one of the heavy metals that is toxic and widely distributed in the environment, and children are more sensitive to the toxic effects of lead because the blood-brain barrier and immune system are not yet well developed. The objective of the study was to investigate the clinical characteristics of lead poisoning in children aged 0∼6 years in a hospital in Guangxi, and to provide scientific basis
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Male reproductive hormone disorders among copper smelter workers. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-11-20 Aisha M Samir,Ahmed M Korany,Hisham Foaad,Marie Manawil
Male workers in copper smelting are exposed to copper, lead, and arsenic. This study aimed to assess the effects of combined exposure to these metals on male reproductive hormone levels and assesses malondialdehyde (MDA) as an oxidative stress parameter. The study was conducted on 40 copper smelter workers compared with 40 non-exposed workers. Laboratory investigations included levels of serum copper
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Health risk assessment of exposure to benzene, toluene, ethyl benzene, and xylene in shoe industry-related workplaces. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-11-07 Amirreza Abouee-Mehrizi,Zahra Soltanpour,Yousef Mohammadian,Akbar Sokouti,Sajjad Barzegar
Benzene, toluene, ethyl benzene, and xylene (BTEX) are prevalent pollutants in shoe industry-related workplaces. The aim of this study was to assess exposure to BTEX and their carcinogenic and non-carcinogenic risks in shoe-industry-related workplaces. This study was carried out at different shoe manufactures, small shoe workshop units, shoe markets, and shoe stores in Tabriz, Iran in 2021. Personal
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Influence of formaldehyde exposure on the molecules of the NO/cGMP-cAMP signaling pathway in different brain regions of Balb/c mice. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-11-03 Xiaoxiao Huang,Fenghua Cao,Wei Zhao,Ping Ma,Xu Yang,Shumao Ding
This toxicology study was conducted to assess the impact of formaldehyde, a common air pollutant found in Chinese gymnasiums, on the brain function of athletes. In this research, a total of 24 Balb/c male mice of SPF-grade were divided into four groups, each consisting of six mice. The mice were exposed to formaldehyde at different concentrations, including 0 mg/m3, 0.5 mg/m3, 3.0 mg/m3, and 3.0 mg/m3
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Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-25 Rania Elbanna,Khaled A Osman,Maher S Salama
Deltamethrin is one of the most effective pyrethroid compounds, widely employed in veterinary medicine, public health, and farming. Deltamethrin-triggered oxidative stress largely causes serious harm to an organism. Acute toxicity of this compound was extensively investigated, while less information is available on its oral sub-acute effects. This study assessed, in the male Albino rats, the effects
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Adverse Health Effects and Perceived Musculoskeletal Pain in the Sawmill Workers of West Bengal, India. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-25 Banibrata Das
The present study aimed to determine the prevalence of musculoskeletal pain, unfavorable working conditions, and assessment of occupational injuries among sawmill workers. The Nordic Musculoskeletal Questionnaire, measurement of handgrip strength, working environment, and occupational injuries were assessed among 135 sawmill workers participating in the study. The data showed that sawmill workers complained
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Toxic potential assessment of hair dye developer 2,4,5,6-tetraaminopyrimidine sulfate exposed under ambient UVB radiation. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-24 Saumya Shukla,Priyanka Chauhan,Prakriti Gaur,Priyanka Rana,Sunil Kumar Patel,Deepti Chopra,Apeksha Vikram,Gaurav Prajapati,Akhilesh Kumar Yadav,Sumana Y Kotian,Lakshmi Bala,Ashish Dwivedi,Aradhana Mishra
Synthetic cosmetics, particularly hair dyes, are becoming increasingly popular among people of all ages and genders. 2,4,5,6-tetraaminopyrimidine sulfate (TAPS) is a key component of oxidative hair dyes and is used as a developer in several hair dyes. TAPS has previously been shown to absorb UVB strongly and degrade in a time-dependent manner, causing phototoxicity in human skin cells. However, the
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Effects of silver nanoparticles prepared by aqueous extract of Ferula communis on the developing mouse embryo after maternal exposure. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-23 Amin A Seleem,Belal Hm Hussein
Green synthesis of silver nanoparticles (AgNPs) from aqueous silver nitrate has been achieved using an extract of Ferula communis leaf as a capping, reducing, and stabilizing agent. The formation and stability of the green synthesized silver nanoparticles in the colloidal solution were monitored by absorption measurements. Silver nanoparticles were characterized by different analyses such as X-ray
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Associations of semen quality with pyrethroids in semen and urine samples of men with oligozoospermia: A cross-sectional study in Samsun, Turkey. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-20 Murat Alagöz,Selma Yazar,Hale Secilmis Canbay,Abdullah Acıkgöz,Burcin S Corba
Pyrethroids (PYRs) may act as endocrine disrupters and lead to infertility. The aim of the study was to analyze the levels of anti-androgenic PYRs (cypermethrin, deltamethrin, and permethrin) and 3-phenoxy benzoic acid (3-PBA), a general metabolite of PYRs, in both semen and urine samples of men with oligozoospermia. The PYRs and 3-PBA metabolite levels in the semen and urine samples of the men were
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The application of acute oral toxicity computational models in dangerous goods classification. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-20 Chandrika Moudgal,Lennart T Anger,Wolfgang Muster,Ruthi Nguyen,Fjodor Melnikov,Vishal B Siramshetty,Jessica Graham
Acute oral toxicity (AOT) data inform the acute toxicity potential of a compound and guides occupational safety and transportation practices. AOT data enable the categorization of a chemical into the appropriate AOT Globally Harmonized System (GHS) category based on the severity of the hazard. AOT data are also utilized to identify compounds that are Dangerous Goods (DGs) and subsequent transportation
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Inorganic arsenic-mediated upregulation of TUG1 promotes apoptosis in human bronchial epithelial cells by activating the p53 signaling pathway. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-20 Qian Chen,Mingjun Sun,Huirong Cheng,Jun Qi,Jingwen Tan,Yun Gu,Tianle Yu,Ming Li,Hao Xu,Yuefeng He,Weihua Wen
Exposure to arsenic, an environmental contaminant, is known to cause arsenicosis and cancer. Although considerable research has been conducted to understand the underlying mechanism responsible for arsenic-induced cancers, the precise molecular mechanisms remain unknown, especially at the epigenetic regulation level. Long non-coding RNAs (LncRNAs) that have been shown to mediate various biological
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A systematic review of the risk management frameworks for potentially toxic chemical elements. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-18 Sheunesu Ngwenya,Ntsieni S Mashau,Sphiwe E Mhlongo,Afsatou N Traoré
In the last 50 years, various frameworks have been used to control and manage potentially toxic chemical risks; however, these chemicals continue to negatively impact environmental and human health. This work was intended to provide a systematic review of the literature on essential aspects of current risk management frameworks for potentially toxic chemicals. The frameworks were reviewed using Organisation
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Hepatic ultrastructural alterations induced by copper oxide nanoparticles: In vivo electron microscopy study. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-10-03 Qais Jarrar,Mansour Almansour,Bashir Jarrar,Amin Al-Doaiss,Ali Shati
Copper oxide nanomaterials (CuO NPs) have been widely utilized in many fields, including antibacterial materials, anti-tumor, osteoporosis treatments, imaging, drug delivery, cosmetics, lubricants for metallic coating, the food industry, and electronics. Little is known about the potential risk to human health and ecosystems. The present work was conducted to investigate the ultrastructural changes
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The endocrine disrupting effects of nanoplastic exposure: A systematic review. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-09-27 Veruscka Leso,Beatrice Battistini,Ilaria Vetrani,Liberata Reppuccia,Mauro Fedele,Flavia Ruggieri,Beatrice Bocca,Ivo Iavicoli
Good mechanical properties and low costs have led to a global expansion of plastic production and use. Unfortunately, much of this material can be released into the environment as a waste product and cleaved into micro- and nanoplastics (NPs) whose impact on the environment and human health is still largely unknown. Considering the growing worldwide awareness on exposure to chemicals that can act as
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Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-09-27 B Baali,L Kirane-Amrani,L Tichati,R Soual,K Ouali
The present study investigated the toxic effects of sub-chronic exposure to copper quinolate (CuQ) fungicide on liver and kidney function. Twenty-four adult male Wistar rats were equally divided into a control group, and three treated groups received, respectively, by oral gavage, three increasing doses of CuQ: 47; 67.1; and 94 mg/kg b.w corresponding, respectively, LD50/100, LD50/70, and LD50/50 daily
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Probucol neuroprotection against manganese-induced damage in adult Wistar rat brain slices. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-09-13 Sarah Camboim Del Rio Naiz,Karina Giacomini Varela,Diego de Carvalho,Aline Pertile Remor
Manganese (Mn) is an abundant element used for commercial purposes and is essential for the proper function of biological systems. Chronic exposure to high Mn concentrations causes Manganism, a Parkinson's-like neurological disorder. The pathophysiological mechanism of Manganism remains unknown; however, it involves mitochondrial dysfunction and oxidative stress. This study assessed the neuroprotective
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Exposure to MMVF in residential and commercial buildings: A literature review and quantitative synthesis. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-09-01 Laura H Allen,Natalie Suder Egnot,Hannah Allen,Kathy Chan,Gary Marsh
Man-made vitreous fibers (MMVF) are a class of inorganic fibrous materials that include glass and mineral wools, continuous glass filaments, and refractory ceramic fibers valued for their insulative properties in high temperature applications. Potential health effects from occupational exposure to MMVF have been investigated since the 1970s, with focus on incidence of respiratory tract cancer among
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Acrolein increases the concentration of intracellular Zn2⁺ by producing mitochondrial reactive oxygen species in A549 cells. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-08-30 Xueqi Liu,Wenwu Sun,Jianping Cao,Zhuang Ma
Smoking or occupational exposure leads to low concentrations of acrolein on the surface of the airways. Acrolein is involved in the pathophysiological processes of various respiratory diseases. Reports showed that acrolein induced an increase in mitochondrial reactive oxygen species (mROS). Furthermore, exogenous H₂O₂ was found to increase intracellular Zn2⁺ concentration ([Zn2⁺]ᵢ). However, the specific
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Antioxidants and mitochondrial/lysosomal protective agents reverse toxicity induced by titanium dioxide nanoparticles on human lymphocytes. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-08-18 Evelyn Assadian,Zhaleh Jamali,Ahmad Salimi,Jalal Pourahmad
Most of the literature has focused on titanium dioxide (TiO2) nanoparticles (NPs) toxicity, showing the importance of oxidative stress, mitochondrial dysfunction, and cell death in TiO2-induced toxicity. For this purpose, in the current study, we investigated the protective role of antioxidant and mitochondrial/lysosomal protective agents to minimize TiO2 NPs-induced toxicity in human lymphocytes.
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Ecotoxicological response surface analysis of salt and pH in textile effluent on Bacillus subtilis and Lactuca sativa. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-08-02 Pedro H Mainardi,Ederio D Bidoia
Textile effluents, although their composition can vary considerably, typically contain high levels of dissolved salts and exhibit wide variations in pH. Ecotoxicological studies regarding the effects of these parameters, however, have been limited owing to the need for sensitive and easy-to-handle bioindicators that require low amounts of sampling, are cost-effective, time-efficient, and ethically
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Occupational exposure to cosmetic talc and mesothelioma in barbers, hairdressers, and cosmetologists: A systematic review of the epidemiology. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-08-01 Ryan C Lewis,Sierra J Smith,Callan F Krevanko,Ethan D Hall,Eric W Miller,Evan M Beckett,Jennifer S Pierce
Inhalation exposure to cosmetic talc has generated much scientific debate regarding its potential as a risk factor for mesothelioma, a rare, but fatal cancer. Barbers, hairdressers, and cosmetologists have regularly used cosmetic talc-containing products, but the collective epidemiological evidence for mesothelioma in these occupations has yet to be described. As such, we conducted a systematic review
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Cytotoxicity and genotoxicity evaluation of chloroform using Vicia faba roots. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-30 Xue Li,Ang Li,Ming Zhang,Tianpeng Gao
Chloroform is a widely used industrial chemical that can also pollute the environment. The aims of this study were to examine the potential cytotoxicity and genotoxicity of chloroform on plant cells, using the Vicia faba bioassay. Chloroform was evaluated at concentrations of 0.1, 0.5, 1, 2, and 5 mg·L-1. The following parameters were analyzed: the mitotic index (MI), micronucleus (MN) frequency, chromosomal
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Effect biomarkers of nanoparticle-exposed workers: A scoping review. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-25 Diana Blank-Porat,Eric Amster
The widespread and increasing use of engineered nanomaterials (i.e., particulate materials measuring 1-100 nanometers (nm) in at least one dimension) poses a potential health and safety risk to exposed workers. The unique properties of nanomaterials have made nanomaterials useful in multiple industries. However, their production and use may compromise worker health, presenting an emerging occupational
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The role of Kupffer cell activation in immune liver damage induced by trichloroethylene associated with the IFN-γ/STAT1 signaling pathway. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-14 Si-Fan Zhou,Qiong-Ying Xu,Yi Yang,Hai-Bo Xie,Jia-Xiang Zhang,Qi-Xing Zhu
Trichloroethylene (TCE) is a metal detergent commonly used in industry that can enter the human body through the respiratory tract and skin, causing occupational medicamentosa-like dermatitis due to TCE (OMDT) and multiple organ damage, including liver failure. However, the pathogenesis of liver injury remains unclear. Kupffer cells (KCs) are important tissue macrophages in the body because the polarization
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Clastogenic, aneugenic, and tubulin polymerization properties of di-(2-ethylhexyl) phthalate and dibutyl phthalate. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-12 Kalpana Javaji,Jhansi Mamilla,Shruti S Deshpande,Raju Y Kanaka,Ramars Amanchy,Sunil Misra
Phthalate compounds were found to disrupt the endocrine system and alter transcriptomes during human embryonic development. In our previous work, we have isolated and reported two such phthalates di-(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) from Brevibacterium mcbrellneri bacteria and evaluated their bioactive properties. Naturally derived phthalates might be less toxic compared with
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Toxic effects of ship exhaust gas closed-loop scrubber wash water. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-07 Zhiyi Ji,Yunqi Yang,Ying Zhu,Yun Ling,Dezhang Ren,Nahui Zhang,Zhibao Huo
To meet the strict requirements of reducing sulfur emissions, an increasing number of commercial ships have installed exhaust gas cleaning systems (EGCSs). However, wash water produced during the cleaning process is discharged back to the marine environment. We investigated the effects of closed-loop scrubber (natrium-alkali method) wash water on three trophic species. Severe toxic effects were found
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Toxicity of methomyl insecticides to testicular cells and protective effect of folic acid. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-06 Mengxi Lu,Yi Liu
Methomyl is a carbamate insecticide with confirmed testicular toxicity. This study intended to observe the effect of methomyl on testicular cells and the protective effect of folic acid through in vitro experiments. The GC-1 spermatogonia, TM4 Sertoli cells, and TM3 Leydig cells were treated with methomyl (0, 250, 500, and 1000 μM) with or without folic acid (0, 10, 100, and 1000 nM) for 24 h. It was
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Effects of sodium para-aminosalicylic acid on chelation treatment in Pb-exposed mice. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-05 Yan Li,Yuan Liang,Yuan-Yuan Fang,Jing Chen,Xiao-Wei Zheng,Wu-Wang Zhou,Li-Li Lu,Michael Aschner,Shi-Yan Ou,Yue-Ming Jiang
Lead (Pb) is a corrosion-resistant, heavy, non-ferrous metal. Several metal chelators have been used for the treatment of Pb poisoning. However, the efficacy of sodium para-aminosalicylic acid (PAS-Na) in enhancing Pb excretion has yet to be fully characterized. Healthy male mice (90) were divided into six groups, the normal control group was intraperitoneally (i.p.) injected with saline and the remaining
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Does exposure to ammonia concentrations lower than the threshold limit value cause acute pulmonary effects? Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-07-03 Ahmad Soltanzadeh,Seyyed Hassan Adeli,Mohsen Sadeghi Yarandi,Hamidreza Heidari,Mohsen Mahdinia
One of the major toxic effects of exposure to ammonia is the resulting pulmonary acute and chronic effects. This study investigated the acute pulmonary effects of exposure to ammonia lower than the recommended threshold limit value (TLV). This cross-sectional study was conducted in 2021 in four chemical fertilizer production industries using ammonia as the main raw material. A total of 116 workers
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Hematotoxicity induced by simultaneous exposure to noise and toluene in New Zealand white rabbits: Synergistic and antagonistic effects. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-06-11 Amirreza Abouee-Mehrizi,Yahya Rasoulzadeh,Saeed Solali,Hadi Esmaeilizadeh,Zeynab Iraji,Mehran Mesgari-Abbasi
Exposure to numerous pollutants is prevalent in workplaces. Examination of combined exposure to different harmful physical factors and chemicals has offered new insights into toxicology in recent years. This study aimed to investigate the hematological alterations caused by exposure to noise and toluene. Twenty-four New Zealand white rabbits were exposed to 1000 ± 50 ppm toluene and/or 100 ± 5 dB noise
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Histological changes in liver and kidney of male mice by age after exposure to aluminum chloride. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-06-06 Yulia Irnidayanti,Dian Fatona,Vina Rizkawati
The informal aluminum industry is increasingly widespread in low- and middle-income countries, especially in Indonesia. Aluminum exposure is a serious public health problem, especially among workers in the informal aluminum foundry sector. Research on aluminum (Al) is important to advance our understanding of its impact on physiological systems. Here, we investigated the effect of exposure to aluminum
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Adverse effects of copper, manganese and mercury, alone and in mixtures on the aorta and heart of Spraque-Dawley rats. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-06-04 M Janse van Rensburg,M J Bester,M J van Rooy,H M Oberholzer
Cardiovascular diseases (CVD) are a common global cause of death and are therefore a major health concern. Inhaled or ingested environmental heavy metals contribute to the development of CVD. The aim of this study was to address the limited information available on the effect of relevant dosages of metals in mixtures. Three metals with reported effects on the cardiovascular system (CVS) were identified
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Methylene diphenyl diisocyanate occupational exposure data in industry (1998-2020): A descriptive summary from an industrial hygiene perspective. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-06-02 Mark W Spence,Patrick M Plehiers,Angel George,Jeanne Hankett
This paper provides an overview of airborne methylene diphenyl diisocyanate (MDI) concentrations in workplaces across North America and Europe. A total of 7649 samples were collected between 1998 and 2020 by producers of MDI during product stewardship activities at customer sites, primarily using validated OSHA or ISO sampling and analysis techniques. As would be expected from the low vapor pressure
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Evaluation of workplace exposure to respirable crystalline silica in road construction industries in Alberta. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-05-31 Ariel Couture,Rose Marie Charuvil Elizabeth,Lianne Lefsrud,Fereshteh Sattari
Occupational exposure to respirable crystalline silica (RCS) is common for several occupations in construction, not only because of its presence in many handling materials but also in processes such as grinding and sawing. This study investigated workplace exposure to RCS as quartz in industries and occupations within road construction in Alberta through the RCS monitoring database provided by the
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Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin's mitigating effect. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-05-30 Muftau Shittu,Suleiman Folorunsho Ambali,Joseph Olusegun Ayo,Mohammed Umaru Kawu,Motunrayo Ganiyat Akande,Zainab Abdulmalik
The ability of melatonin to reduce growth inadequacy induced by parental and nutritional combination administration to chlorpyriphos (Ch) and cypermethrin (Cy) was examined in male albino rats. Oral alimentation was given to gravid dams divided into six groups (n = 10; age: 12 weeks) from the first day of pregnancy to the 21st postnatal day. Distilled water (DW), Soya oil (SYO), and melatonin (MeL)
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Toxicity of para-phenylenediamine (PPD;1, 4 diaminobenzene) on isolated human lymphocytes: The key role of intracellular calcium enhancement in PPD-induced apoptosis. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-05-27 Maryam Salami,Jalal Pourahmad,Mohammad Hadi Zarei
Para-phenylenediamine (PPD) is a derivative of benzene used as an ingredient in dyes, a photographic developing agent, and a component of engineered polymers. The carcinogenicity of PPD, which has been documented in several studies, may be related to its toxic effects on different compartments of the immune system. The main goal of this research was to evaluate the mechanism of the toxicity of PPD
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The effect of subacute co-exposure to carbon tetrachloride and diclofenac on the liver of male wistar rats. Toxicol. Ind. Health (IF 1.9) Pub Date : 2023-05-19 Zahra Hassanpour,Farshad H Shirazi,Sara Shokrpoor,Rasoul Yarahmadi,Narges Moghadasi,Mehran Vosoogh,Azadeh Ashtarinezhad
Carbon tetrachloride (CCl4) is a potent liver toxin. Diclofenac (Dic), leading adverse effects on the liver, is used among the employees of the industries that use CCl4. The increased use of CCl4 and Dic in industrial workers has prompted us to investigate their synergistic effect on the liver using male Wistar rats as a model. Male Wistar rats were divided into seven groups (n = 6), and the exposure