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A Biomarker-Centric Framework for the Prediction of Future Chronic Pain medRxiv. Pain Med. Pub Date : 2024-04-20 Matt Fillingim, Christophe Tanguay-Sabourin, Marc Parisien, Azin Zare, Gianluca V. Guglietti, Jax Norman, Bogdan Petre, Andrey Bortsov, Mark Ware, Jordi Perez, Mathieu Roy, Luda Diatchenko, Etienne Vachon-Presseau
Chronic pain is a multifactorial condition presenting significant diagnostic and prognostic challenges. Biomarkers for the classification and the prediction of chronic pain are therefore critically needed. In this multi-dataset study of over 523,000 participants, we applied machine learning to multi-dimensional biological data from the UK Biobank to identify biomarkers for 35 medical conditions associated
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Protocol for semantic segmentation of spinal endoscopic instruments and anatomic structures : how far is robotic endoscopy surgery? medRxiv. Pain Med. Pub Date : 2024-04-15 Guoxin Fan, Guanghui Yue, Zhouyang Hu, Zhipeng Xu, Jianjin Zhang, Hong Wang, Xiang Liao
Background Automatic analysis of endoscopic images will played an important role in the future spine robotic surgery. The study is designed as a translational study to develop AI models of semantic segmentation for spinal endoscopic instruments and anatomic structures. The aim is to provide the visual understanding basis of endoscopic images for future intelligent robotic surgery.
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“Mitigating Cancer Pain: What else Matters?”—A Qualitative Study into the Needs and Concerns of Cancer Patients in Sri Lanka medRxiv. Pain Med. Pub Date : 2024-04-15 NP Edirisinghe, PTR Makuloluwa, AATD Amarasekara, CSE Goonewardena
Objectives The overall experience of cancer pain reflects patients’ needs and concerns. Therefore, a thorough understanding of the patient’s needs and concerns is crucial to implementing satisfactory pain outcomes. This study aims to explore the needs and concerns of patients with cancer pain in Sri Lanka.
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Design of the COMEBACK and BACKHOME Studies, Longitudinal Cohorts for Comprehensive Deep Phenotyping of Adults with Chronic Low-Back Pain (cLBP): a part of the BACPAC Research Program medRxiv. Pain Med. Pub Date : 2024-04-12 Trisha F. Hue, Jeffrey C. Lotz, Patricia Zheng, Dennis M. Black, Jeannie Bailey, Susan K. Ewing, Aaron J. Fields, Wolf Mehling, Aaron Scheffler, Irina Strigo, Thomas Petterson, Lucy A. Wu, Conor O’Neill, The UCSF REACH Center, the CoRe CEnter for PAtient-Centric Mechanistic PHenotyping in Chronic Low Back Pain
Objective The University of California, San Francisco (UCSF) Core Center for Patient-centric, Mechanistic Phenotyping in Chronic Low Back Pain (REACH) is one of the three NIH Back Pain Consortium (BACPAC) Research Programs Mechanistic Research Centers (MRCs). The goal of UCSF REACH is to define cLBP phenotypes and pain mechanisms that can lead to effective, personalized treatments for patients across
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Statistical learning shapes pain perception and prediction independently of external cues. medRxiv. Pain Med. Pub Date : 2024-03-29 Jakub Onysk, Nicholas Gregory, Mia Whitefield, Maeghal Jain, Georgia Turner, Ben Seymour, Flavia Mancini
The placebo and nocebo effects highlight the importance of expectations in modulating pain perception, but in everyday life we don't need an external source of information to form expectations about pain. The brain can learn to predict pain in a more fundamental way, simply by experiencing fluctuating, non-random streams of noxious inputs, and extracting their temporal regularities. This process is
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The Role of Cytokines in Acute and Chronic Postsurgical Pain in Pediatric Patients after Major Musculoskeletal Surgeries medRxiv. Pain Med. Pub Date : 2024-03-28 Vidya Chidambaran, Qing Duan, Valentina Pilipenko, Susan Glynn, Alyssa Sproles, Lisa J Martin, Michael Lacagnina, Christopher D King, Lili Ding
Study Objective: To determine if baseline cytokines and their changes over postoperative days 0-2 (POD0-2) predict acute and chronic postsurgical pain (CPSP) after major surgery. Design: Prospective, observational, longitudinal nested study. Setting: University-affiliated quaternary childrens hospital. Patients: Subjects (≥8 years old) with idiopathic scoliosis undergoing spine fusion or pectus excavatum
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Mortality of adults with chronic noncancer pain: a systematic review and meta-analysis medRxiv. Pain Med. Pub Date : 2024-03-24 Stephanie Webb, Antonia-Olivia Roberts, Lauren Scullion, Georgia C Richards
It is recognised that chronic pain is one of the leading causes of disabilities worldwide. However, statistics on mortality and causes of death in people with chronic noncancer pain (CNCP) have been difficult to determine. This systematic review aimed to determine the mortality rate in people with all types of CNCP and the associated causes and risk factors of death. MEDLINE (Ovid) and EMBASE (Ovid)
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Mixed Methods Family Centered Study of Pain Experience in Non-Hispanic White and Black Children medRxiv. Pain Med. Pub Date : 2024-03-22 Julia Kumar, Dylan Atkinson, Adaora Chima, Laura McLaughlin, Rajvi Parikh, Peter Mende-Siedlecki, Monica Mitchell, Vidya Chidambaran
Background and Objectives: Although racial disparities in pediatric pain have been described, family-centered research is lacking. This mixed-methods study aimed to understand race-specific factors impacting acute pain experiences in Non-Hispanic White (NHW) and Black (NHB) children. Methods: NHW and NHB children (aged 8-17) (n=19 each) with a recent acute pain experience, and their caregivers were
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Localized and Widespread Chronic Pain in Sexual and Gender Minority People: An Analysis of The PRIDE Study medRxiv. Pain Med. Pub Date : 2024-03-19 Andrea L Chadwick, Nadra Lisha, Micah E Lubensky, Zubin Dastur, Mitchell R Lunn, Juno Obedin-Maliver, Annesa Flentje
Sex related differences, without taking gender into account, in chronic pain have been widely researched over the past few decades in predominantly cisgender and heterosexual populations. Historically, chronic pain conditions have a higher incidence and prevalence in cisgender women, including but not limited to fibromyalgia, irritable bowel syndrome, and migraine. The goal of the present study was
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Perceived and endocrine acute and chronic stress indicators in fibromyalgia syndrome medRxiv. Pain Med. Pub Date : 2024-03-16 Eva Beiner, Michelle Hermes, Julian Reichert, Kristian Kleinke, Stephanie Vock, Annette Loeffler, Leonie Ader, Andrei Sirazitdinov, Sebastian Keil, Tim Schmidt, Anita Schick, Martin Loeffler, Michael Hopp, Christian Ruckes, Juergen Hesser, Ulrich Reininghaus, Herta Flor, Wolfgang Eich, Hans-Christoph Friederich, Jonas Tesarz
Introduction: Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue and tenderness and closely associated with high levels of stress. FMS is therefore often considered a stress-related disease. Methods: A comparative study was conducted with 99 individuals diagnosed with FMS and a control group of 50 pain-free individuals. Stress indicators were
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Clinical characterization of new-onset chronic musculoskeletal pain in Long COVID: a cross-sectional study medRxiv. Pain Med. Pub Date : 2024-03-15 Omar Khoja, Bárbara Silva-Passadouro, Elena Cristescu, Katie McEwan, Derek Doherty, Fiona OConnell, Frederique Ponchel, Matthew Mulvey, Sarah Astill, Ai Lyn Tan, Manoj Sivan
Purpose: New-onset chronic musculoskeletal (MSK) pain is one of the common persistent symptoms in Long COVID (LC). This study investigated its clinical characteristics, underlying mechanisms, and impact on function, psychological health, and quality of life. Patients and methods: 30 adults (19 female, 11 male) with LC and new-onset chronic MSK pain underwent clinical examination, Quantitative Sensory
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Divergent treatment responses in chronic pain: Identifying subgroups of patients through cluster analysis. medRxiv. Pain Med. Pub Date : 2024-02-24 Mienke Rijsdijk, Hidde M Smits, Hazal R Azizoglu, Sylvia Brugman, Yoeri van de Burgt, Tessa C van Charldorp, Dewi J van Gelder, Janny C de Grauw, Eline A van Lange, Frank J Meye, Madelijn Strick, Hedi Walravens, Laura H.H. Winkens, Frank J.P.M. Huygen, Julia Drylewicz, Hanneke LDM Willemen
Background: Chronic pain is an ill-defined disease with complex biopsychosocial aspects, posing treatment challenges. We hypothesize that treatment failure results, at least partly, from limited understanding of diverse patient subgroups. We aim to identify subgroups through psychometric data, allowing for more tailored interventions. Methods: For this retrospective cohort study, we extracted patient-reported
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Neuropsychology of chronic back pain managed with long-term opioid use medRxiv. Pain Med. Pub Date : 2024-02-08 Marwan N Baliki, Andrew D. Vigotsky, Gaelle Rached, Rami Jabakhanji, Lejian Huang, Paulo Branco, Olivia Cong, James Griffith, Ajay D. Wasan, Thomas J. Schnitzer, A. Vania Apkarian
Chronic pain is commonly treated with long-term opioids, but the neuropsychological outcomes associated with stable long-duration opioid use remain unclear. Here, we contrasted the psychological profiles, brain activity, and brain structure of 70 chronic back pain patients on opioids (CBP+O, average opioid exposure 6.2 years) with 70 patients managing their pain without opioids. CBP+O exhibited moderately
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Development and Validation of The Activity-Based Checks (ABCs) of Pain: A Functional Pain Scale medRxiv. Pain Med. Pub Date : 2024-01-30 Celina G Virgen, Robert Wright, Bryan Renslo, Tuleen Sawaf, Hanna Moradi, Maria Edelen, Jennifer Villwock
The Activity Based-Checks of Pain (ABCs) is a pain assessment tool incorporating activities of daily living and instrumental activities of daily living. Unlike widely used pain scales which are oftentimes unidimensional and highly subjective, the ABCs was designed to focus on function capabilities and limitations of patients due to pain. This study sought out to validate the factorial structure of
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Age and Sex Differences of Virtual Reality Pain Alleviation Therapeutic During Pediatric Burn Care: A Randomized Clinical Trial medRxiv. Pain Med. Pub Date : 2024-01-28 Katarina Jones, Megan Armstrong, John Luna, Rajan Thakkar, Fabia Renata, Jonathan Groner, Dana Noffsinger, Ai Ni, Bronwyn Griffin, Henry Xiang
Virtual reality (VR) effectively alleviates pain for pediatric patients during many medical care procedures, such as venipuncture and burn wound care. Whether VR pain alleviation therapeutics (VR-PAT) differ by a patients age or sex remains unresolved. This randomized clinical trial evaluated how age and sex affect VR pain alleviation during dressing care for pediatric burns. Ninety patients aged 6
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Evoked oscillatory cortical activity during acute pain: Probing brain in pain by transcranial magnetic stimulation combined with electroencephalogram medRxiv. Pain Med. Pub Date : 2024-01-23 Enrico De Martino, Adenauer Casali, Silvia Casarotto, Gabriel Hassan, Mario Rosanova, Bruno Andry Nascimento Couto, Thomas Graven-Nielsen, Daniel Ciampi de Andrade
Temporal dynamics of local cortical rhythms during acute pain remain largely unknown. The current study used a novel approach based on transcranial magnetic stimulation combined with electroencephalogram (TMS-EEG) to investigate evoked-oscillatory cortical activity during acute pain. Motor (M1) and dorsolateral prefrontal cortex (DLPFC) were probed by TMS, respectively, to record oscillatory power
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Mechanical hyperalgesia and neuropathic pain qualities impart risk for chronic postoperative pain after total knee replacement medRxiv. Pain Med. Pub Date : 2024-01-17 Andrew D. Vigotsky, Olivia Cong, Camila B Pinto, Joana Barroso, Jennifer Perez, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Kevin Hardt, David Manning, A. Vania Apkarian, Paulo Branco
Total knee replacement (TKR) is the gold-standard treatment for end-stage chronic osteoarthritis pain, yet many patients report chronic postoperative pain after TKR. The search for preoperative predictors for chronic postoperative pain following TKR has been studied with inconsistent findings. This study investigates the predictive value of quantitative sensory testing (QST) and PainDETECT for postoperative
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The Burden of Long-Term Opioid Use on Emotional, Cognitive and Sensorimotor Domains in Chronic Back Pain medRxiv. Pain Med. Pub Date : 2024-01-09 Gaelle Rached, Andrew David Vigotsky, Paulo Branco, Rami Jabakhanji, Thomas J Schnitzer, A Vania Apkarian, Marwan N Baliki
We evaluated the incremental effect of opioids on chronic back pain patients (CBP) by comparing 50 CBP on opioid therapy (CBP+O; opioid duration >= 3months) to pain intensity-, pain duration-, age-, and sex- matched CBP who were not on opioids (CBP-O). Participants completed the NIH Toolbox's cognitive, affective, sensory, and motor components. Several emotional domains were negatively impacted by
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The Molecular Signature of Neuropathic Pain in a Human Model System medRxiv. Pain Med. Pub Date : 2024-01-04 Oliver P Sandy-Hindmarch, Pao-Sheng Chang, Paulina Simonne Scheuren, Iara De Schoenmacker, Michèle Hubli, Constantinou Loizou, Stephan Wirth, Devendra Mahadevan, Akira Wiberg, Dominic Furniss, Franziska Denk, Georgios Baskozos, Annina Schmid
Peripheral neuropathic pain remains challenging to treat, partly due to our limited understanding of the molecular mechanisms at play in humans. In this multicentre cohort study, we describe the local molecular signature of neuropathic pain at the lesion site, using peripheral nerves of patients with Morton’s neuroma as a human model system of neuropathic pain.
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An Adaptive Pragmatic Randomized Controlled Trial of Emergency Department Acupuncture for Acute Musculoskeletal Pain Management medRxiv. Pain Med. Pub Date : 2024-01-01 Stephanie A. Eucker, Oliver Glass, Mitchell R. Knisely, Amy O’Regan, Alexander Gordee, Cindy Li, Christopher L. Klasson, Olivia TumSuden, Alena Pauley, Harrison Chen, Catherine A. Staton, Maggie Kuchibhatla, Shein-Chung Chow, Duke Emergency Department Acupuncture Research team
Objective Acute musculoskeletal pain in emergency department (ED) patients is frequently severe and challenging to treat with medications alone. The purpose of this study was to determine the feasibility, acceptability and effectiveness of adding ED acupuncture to treat acute episodes of musculoskeletal pain in the neck, back, and/or extremities.
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Improving Veteran Access to Integrated Management of Back Pain (AIM-Back): Updated Statistical Analysis Plan for this Embedded Pragmatic, Cluster Randomized medRxiv. Pain Med. Pub Date : 2023-12-26 Cynthia J. Coffman, Rebecca North, Steven Z. George, Susan N. Hastings
The Improving Veteran Access to Integrated Management of Back Pain (AIM-Back) pragmatic, embedded, cluster-randomized trial is ongoing with enrollment starting in February 2020 and projected to end in first quarter of 2024. The 3 -month follow up rate of primary outcome data collected as part of an AIM-Back clinical follow-up visit in the electronic health record has been lower than anticipated. At
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Investigating the Effects of Artificial Baroreflex Stimulation on Pain Perception: A Comparative Study in Healthy Participants and Individuals with Chronic Low Back Pain medRxiv. Pain Med. Pub Date : 2023-12-18 Alessandra Venezia, Harriet Fawsitt-Jones, David Hohenschurz-Schmidt, Matteo Mancini, Matthew Howard, Elena Makovac
The autonomic nervous system (ANS) and pain exhibit a reciprocal relationship, whereupon acute pain triggers ANS responses, while resting ANS activity can influence pain perception. Nociceptive signalling can also be altered by "top-down" processes occurring in the brain, brainstem, and spinal cord, known as descending modulation. By employing the Conditioned Pain Modulation (CPM) paradigm, our previous
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Enhancing Patient Safety in Opioid Prescribing: A Systematic Review of Potential Indicators medRxiv. Pain Med. Pub Date : 2023-12-09 Neetu Bansal, Wael Y. Khawagi, Nan Shang, Li-Chia Chen
Background This systematic review aimed to identify a comprehensive list of prescribing safety indicators for opioids in any setting from published literature.
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Artificial Intelligence and Machine Learning in Cancer Related Pain: A Systematic Review medRxiv. Pain Med. Pub Date : 2023-12-08 Vivian Salama, Brandon Godinich, Yimin Geng, Laia Humbert-Vidan, Laura Maule, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Abdallah S. R. Mohamed, Clifton D. Fuller, Amy C. Moreno
Background/objective: Pain is a challenging multifaceted symptom reported by most cancer patients, resulting in a substantial burden on both patients and healthcare systems. This systematic review aims to explore applications of artificial intelligence/machine learning (AI/ML) in predicting pain-related outcomes and supporting decision-making processes in pain management in cancer. Methods: A comprehensive
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Effectiveness of Implementation Interventions in Musculoskeletal Healthcare: A Systematic Review medRxiv. Pain Med. Pub Date : 2023-11-30 Peter Bech Hansen, Mikkel Bahnsen, Mikkel Sloth Nørgaard, Jette Frost Jepsen, Michael Skovdal Rathleff, Kristian Damgaard Lyng
Background Implementing new knowledge into clinical practice is a challenge, but nonetheless crucial to improve our healthcare system related to the management of musculoskeletal pain. This systematic review aimed to assess the effectiveness of implementation interventions within musculoskeletal healthcare.
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How side effects can improve treatment efficacy: a randomized trial medRxiv. Pain Med. Pub Date : 2023-11-22 Lieven A. Schenk, Tahmine Fadai, Christian Büchel
While treatment side effects may adversely impact patients, they could also potentially function as indicators for effective treatment. In this study, we investigated whether and how side effects can trigger positive treatment expectations and enhance treatment outcomes.
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Non-obese lipedema patients show a distinctly altered Quantitative Sensory Testing profile with high diagnostic potential medRxiv. Pain Med. Pub Date : 2023-11-22 Rebecca Dinnendahl, Dominik Tschimmel, Vanessa Löw, Manuel Cornely, Tim Hucho
Background Lipedema is a widespread severe chronic disease affecting mostly women. Characterized by painful bilateral fat accumulation in extremities sparing hands and feet, objective measurement-based diagnosis is currently missing. We tested for characteristic psychometric and/or sensory alterations including pain and for their potential for medical routine diagnostic.
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Exploring the thermally-controlled fentanyl transdermal therapy to provide constant drug delivery by physics-based digital twins medRxiv. Pain Med. Pub Date : 2023-11-20 Flora Bahrami, Agnes Psikuta, René Michel Rossi, Alex Dommann, Thijs Defraeye
Transdermal drug delivery is suitable for low-molecular-weight drugs with specific lipophilicity, like fentanyl, which is widely used for cancer-induced pain management. However, fentanyl’s transdermal therapy displays high intra-individual variability. Factors like skin characteristics at application sites and ambient temperature contribute to this variation. In this study, we developed a physics-based
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Attention and interoception alter perceptual and neural pain signatures medRxiv. Pain Med. Pub Date : 2023-11-06 Maria Niedernhuber, Joaquim Streicher, Bigna Lenggenhager, Tristan A. Bekinschtein
Fluctuations of chronic pain levels are determined by a complex interplay of cognitive, emotional and perceptual variables. We introduce a pain tracking platform composed of wearable neurotechnology and a smartphone application to measure and predict chronic pain levels. Our method measures, dynamically, pain strength, phenomenal and neural time series collected with an online tool and low-density
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Unsupervised subgrouping of chronic low back pain patients treated in a specialty clinic medRxiv. Pain Med. Pub Date : 2023-11-05 Abel Torres Espin, Anastasia Keller, Susan Ewing, Andrew Bishara, Naoki Takegami, Adam R. Ferguson, Aaron Scheffler, Trisha Hue, Jeff Lotzs, Thomas Peterson, Patricia Zheng, Conor O'Neill
Background. Chronic low back pain (cLBP) is the leading cause of disability worldwide. Current treatments have minor or moderate effects, partly because of the idiopathic nature of most cLBP cases, the complexity of its presentation, and heterogeneity in the population. Explaining this complexity and heterogeneity by identifying subgroups of patients is critical for personalized health. Clinical decisions
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Restoration of normal central pain processing following manual therapy in nonspecific chronic neck pain medRxiv. Pain Med. Pub Date : 2023-10-27 Josu Zabala, Jon Jatsu Azkue, Joel E. Bialosky, Marc Saez, Estibaliz Dominguez, Maialen Araolaza, Ion Lascurain
Objective: to determine if a 4-week manual therapy treatment restores normal functioning of central pain processing mechanisms in non-specific chronic neck pain (NSCNP), as well as the existence of a possible relationship between changes in pain processing mechanisms and clinical outcome. Design: cohort study. Methods: sixty-three patients with NSCNP received four treatment sessions (once a week) of
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Transcutaneous Spinal Cord Stimulation to Reduce Phantom Limb Pain in People with a Transtibial Amputation medRxiv. Pain Med. Pub Date : 2023-10-24 Ashley N Dalrymple, Lee E Fisher, Douglas J Weber
Phantom limb pain (PLP) is debilitating and affects over 70% of people with a lower-limb amputation. In chronic pain conditions, there are plastic changes at the spinal cord level, typically causing increased excitability. Altered spinal excitability can be measured using reflexes, such as the posterior root-muscle (PRM) reflex. Neuromodulation of the spinal cord can be used to reduce chronic pain
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Characteristics of patients with myofascial pain syndrome of the low back medRxiv. Pain Med. Pub Date : 2023-10-15 Pao-Feng Tsai, Joseph Edison, Chih-Hsuan Wang, Michael W. Gramlich, Kailea Manning, Gopikrishna Deshpande, Adil Bashir, JoEllen Soften
Objective: Identify characteristics of patients with myofascial pain syndrome (MPS) of the low back. Methods: Twenty-five subjects with myofascial trigger point(s) [MTrP(s)] on the low back participated in this cross-sectional study. The location, number and type (active or latent) of MTrPs were verified by ultrasound; additionally, data on pain pressure threshold, physical function, quality of life
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Metabolomics reveals reasons for the efficacy of acupuncture in migraine patients: The role of anaerobic glycolysis and mitochondrial citrate in migraine relief medRxiv. Pain Med. Pub Date : 2023-10-15 Zishan Gao, Xian-Zhong Yan, Rui Wang-Sattler, Marcela Covic, Guang Yu, Feifei Ge, Jia Lin, Qin Chen, Juan Liu, Sapna Sharma, Sophie Molnos, Brigitte Kuehnel, Rory Wilson, Jonathan Adam, Stefan Brandmaier, Shuguang Yu, Ulrich Mansmann, Fanrong Liang, Christian Gieger
Acupuncture is used worldwide to treat migraine, but its scientific mechanism remains unclear. Here, we report a 1H NMR metabolomics study involving 40 migraine patients and 10 healthy people randomly receiving acupuncture or sham acupuncture, followed by machine learning techniques and functional analysis. We found that acupuncture at acupoints particularly enhanced anaerobic glycolysis and modified
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Gender differences in PTSD severity and pain outcomes: baseline results from the LAMP trial medRxiv. Pain Med. Pub Date : 2023-10-15 Jessica K. Friedman, Brent C. Taylor, Emily Hagel Campbell, Kelli Allen, Ann Bangerter, Mariah Branson, Gert Bronfort, Collin Calvert, Lee JS Cross, Mary A. Driscoll, Roni Evans, John E. Ferguson, Alex Haley, Sierra Hennessy, Laura A Meis, Diana J Burgess
Background: Post-traumatic stress disorder (PTSD) and chronic pain are highly prevalent comorbid conditions. Veterans dually burdened by PTSD and chronic pain experience more severe outcomes compared to either disorder alone. Few studies have enrolled enough women Veterans to test gender differences in pain outcomes [catastrophizing, intensity, interference] by the severity of PTSD. Aim: Examine gender
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Distributions of Recorded Pain in Mental Health Records: A Natural Language Processing Based Study medRxiv. Pain Med. Pub Date : 2023-09-15 Jaya Chaturvedi, Robert Stewart, Mark Ashworth, Angus Roberts
Objective The objective of this study is to determine demographic and diagnostic distributions of physical pain recorded in the clinical notes of a mental health electronic health records database by utilising natural language processing and to examine the level of overlap in recorded physical pain between primary and secondary care. Design, Setting and Participants The data were extracted from an
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Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis medRxiv. Pain Med. Pub Date : 2023-09-08 Patrick Finan, Carly Hunt, Michael L Keaser, Katie Smith, Sheera Lerman, Clifton O. Bingham, Frederick Barrett, Eric L. Garland, Fadel Zeidan, David A. Seminowicz
Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the target. The aim of the current mechanistic randomized controlled trial was to test the effects of a single skill positive emotion-enhancing intervention called Savoring Meditation on pain-related neural
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Comparison of subjective motor imagery abilities in CRPS compared to chronic limb pain and healthy controls: a cross sectional study medRxiv. Pain Med. Pub Date : 2023-09-06 Gabriel COHEN-AKNINE, Alexis HOMS, Denis MOTTET, Thibault MURA, Francois JEDRYKA, Arnaud DUPEYRON
Complex Regional Pain Syndrome (CRPS) is a chronic pain syndrome that affects brain structure and function such as motor imagery. However it is not known whether CRPS patients have a subjective MI deficit. In this single-center observational study, 123 patients were recruited (CRPS = 40, chronic limb pain, CLP = 40 and healthy individuals = 43). Participants completed the Motor Imagery Questionnaire
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Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity medRxiv. Pain Med. Pub Date : 2023-09-05 Wei Li, Andrew Q Pucka, Candice Debats, Brandon Reyes, Fahim Syed, Andrew R OBrien, Rakesh Mehta, Naveen Manchanda, Seethal Jacob, Brandon M Hardesty, Anne Greist, Steven E Harte, Richard E Harris, Qigui Andy Yu, Ying Wang
This study aimed to comprehensively analyze inflammatory and autoimmune characteristics of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to healthy controls (HCs) to explore the pathogenesis of StSt and its impact on patients' well-being. The study cohort consisted of 40 StSt participants and 23 HCs enrolled between July 2021 and April 2023. StSt participants showed
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Machine Learning Reveals Synovial Fibroblast Genes Associated with Pain Affect Sensory Nerve Growth in Rheumatoid Arthritis medRxiv. Pain Med. Pub Date : 2023-08-23 Zilong Bai, Nicholas Bartelo, Maryam Aslam, Caryn Hale, Nathalie Blachere, Salina Parveen, Edoardo Spolaore, Edward DiCarlo, Ellen Gravallese, Melanie Smith, Mayu Frank, Caroline Jiang, Haotan Zhang, Myles Lewis, Shafaq Sikandar, Costantino Pitzalis, Anne-Marie Malfait, RACHEL MILLER, Fan Zhang, Susan Goodman, Robert B Darnell, Fei Wang, Dana Orange
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal that pain scores in patients do not correlate with synovial inflammation. We identified a module of 815 genes associated with pain, using a novel machine learning approach, Graph-based Gene expression Module Identification (GbGMI), in samples from patients with longstanding
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Single-dose epidural bupivacaine vs placebo after lumbar decompression surgery: A Randomized controlled trial medRxiv. Pain Med. Pub Date : 2023-08-21 Sem Hermans, Aniek Lantinga-Zee, Ruud Droeghaag, Henk van Santbrink, Wouter van Hemert, Mattheus Reinders, Daisy Hoofwijk, Sander van Kuijk, Kim Rijkers, Inez Curfs
Introduction Adequate postoperative pain management following lumbar spinal decompression surgery is important as it will lead to early mobilization, less complications and shorter hospital stay. Opioid consumption should be limited due to their frequently accompanied side effects and their addictive nature. During the final phase of lumbar decompression surgery, the epidural space becomes easily accessible
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Stellate Ganglion Block to Treat Long COVID-19 Syndrome, A 41 Patient Retrospective Cohort Study medRxiv. Pain Med. Pub Date : 2023-08-15 Lisa Pearson, Alfred Maina, Leah Thompson, Sherri Harden, Abbey Aaroe, Taylor Compratt
Post Covid-19 condition (PCC), long COVID-19 syndrome and post-acute sequelae of SARS-CoV-2 (PASC) all refer to a constellation of symptoms that are unresolved long after the acute phase of the viral infection. The severity of symptoms varies from mild and tolerable to severe and debilitating 1, 2. Due to the evolving nature of the SARS-CoV-2 pandemic, treatment protocols for the acute illness are
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A fearful adult attachment style is associated with double the prevalence of chronic pain compared to secure attachment: A national survey of a South African population medRxiv. Pain Med. Pub Date : 2023-08-04 Gabriella Elisabeth Stamp, Stella Iacovides, Antonia Louise Wadley
Our response to threats, including pain, are believed to be learnt during our early interpersonal relationships, and can be measured through attachment style. Preliminary epidemiological evidence suggests that insecure attachment styles are more prevalent in those with chronic pain. Our aim was to determine the association between adult attachment style and chronic pain prevalence and burden in a South
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Translational impact of basic science promotes a new era of precision medicine for migraine medRxiv. Pain Med. Pub Date : 2023-07-28 Frank Porreca, Edita Navratilova, Joe Hirman, Antoinette MaassenVanDenBrink, Richard B Lipton, David W Dodick
Precision medicine has emerged as a powerful approach to improve treatment outcomes for many medical conditions by consideration of the genetic characteristics of the patient. Migraine is likely to be the world's most common neurological disorder affecting over 1 billion people, approximately 700 million of whom are women. Yet, patient sex, the most basic genetic difference, is rarely considered in
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Industry payments to anesthesiologists in the United States between 2014 and 2022 medRxiv. Pain Med. Pub Date : 2023-07-27 Anju Murayama
Background: Financial relationships between physicians and the healthcare industry could be beneficial to improve patient care, but could lead to conflicts of interest. However, there was no study specifically evaluating the extent of financial relationships between anesthesiologists and the healthcare industry in the United States. Methods Using the Open Payments Database between 2014 and 2022, this
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The Effects of Virtual Reality Neuroscience-based Therapy on Clinical and Neuroimaging Outcomes in Patients with Chronic Back Pain: A Randomized Clinical Trial medRxiv. Pain Med. Pub Date : 2023-07-27 Marta Ceko, Tassilo Baeuerle, Lynn Webster, Mark Lumley, Tor Wager
Chronic pain remains poorly managed. The integration of innovative immersive technologies (i.e., virtual reality (VR)) with recent neuroscience-based principles that position the brain as the key organ of chronic pain may provide a more effective pain treatment than traditional behavioral therapies. By targeting cognitive and affective processes that maintain pain and potentially directly changing
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Can a specific biobehavioral based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. medRxiv. Pain Med. Pub Date : 2023-07-23 Silvia Di Bonaventura, Raúl Ferrer-Peña, Josué Fernández-Carnero
Background Chronic pain conditions are complex multifactorial disorders with physical, psychological and environmental factors contributing to their onset and persistence. Among these conditions, the role of brain-derived neurotrophic factor (BDNF) and the impact of therapeutic education (TE) on pain management have emerged as important areas of research. OBJECTIVE The aim of this study is to investigate
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Modulation of Neural Networks and Symptom Correlated in Fibromyalgia: A Randomized Double-blind Factorial Explanatory Clinical Trial of Home-Based Transcranial Direct Current Stimulation medRxiv. Pain Med. Pub Date : 2023-07-13 Rael Lopes Alves, Maxciel Zortea, Paul Vicuña Serrano, Vani dos Santos, Betina Franceschini Tocchetto, Leticia Ramalho, Camila Fernanda da Silveira Alves, Rafaela Brugnera Tomedi, Rodrigo Pereira de Almeida, Samara Machado Bruck, Liciane Medeiros, Paulo R. S. Sanches, Danton P. Silva, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo
Transcranial direct current stimulation (tDCS) might modulate neural activity and promote neural plasticity. This factorial randomized clinical trial compared a-tDCS on the left dorsolateral prefrontal cortex (l-DLPFC) or sham (s-tDCS), and a-tDCS or s-tDCS on the primary motor cortex (M1) in the connectivity analyses in eight regions of interest (ROIs) across eight resting-state electroencephalography
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An Exploratory Study of the Association Between Preoperative Pain Catastrophizing Scale Scores and Postoperative Pain Experience in Total Knee Arthroplasty medRxiv. Pain Med. Pub Date : 2023-07-12 Christopher J Gill, Karen Giuliano
Introduction. Opiate misuse is increasingly common and can result from a single opiate exposure. High pain catastrophizing scores have been linked with greater reported pain and increased opiate use in outpatient studies, but this association has not previously been established in a perioperative setting. Methods. A quantitative, cross-sectional pilot study was conducted on 21 patients undergoing total
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Epidemiology of chronic pain and opioid use in primary care – a scoping review of big data research medRxiv. Pain Med. Pub Date : 2023-06-13 Junlin Lin, Hongdian Zhu, Greg Murray, Audrey P Wang
Objective Recent research addressing the opioid use and misuse crisis in patients with chronic non-cancer pain in primary care has focused on traditional cohort studies underpinned by survey data. The advent of electronic health records creates a ′big data′ opportunity for improving our understanding of the epidemiology of chronic non-cancer pain in primary care and opioid use and misuse. This scoping
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Multimodal Pain Recognition in Postoperative Patients: A Machine Learning Approach medRxiv. Pain Med. Pub Date : 2023-06-12 Ajan Subramanian, Rui Cao, Emad Kasaeyan Naeni, Syed Amir Hossein Aqajari, Thomas D. Hughes, Michael-David Calderon, Kai Zheng, Nikil Dutt, Pasi Liljeberg, Sanna Salanterä, Ariana M. Nelson, Amir M. Rahmani
Objective To develop and evaluate a multimodal machine learning-based objective pain assessment algorithm on data collected from post-operative patients. Methods The proposed method addresses the major challenges that come with using data from such patients like the imbalanced distribution of pain classes and the scarcity of ground-truth labels. Specifically, we extracted automatic features using a
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Causal Interactions in Brain Networks Predict Pain Levels in Trigeminal Neuralgia medRxiv. Pain Med. Pub Date : 2023-06-05 Yun Liang, Qing Zhao, John K. Neubert, Mingzhou Ding
Trigeminal neuralgia (TN) is a highly debilitating facial pain condition. Magnetic resonance imaging (MRI) is the main method for generating insights into the central mechanisms of TN pain in humans. Studies have found both structural and functional abnormalities in various brain structures in TN patients as compared with healthy controls. Whereas studies have also examined aberrations in brain networks
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Combining Procedural and Behavioral Treatments for Chronic Low Back Pain: A Pilot Feasibility Randomized Controlled Trial medRxiv. Pain Med. Pub Date : 2023-06-05 Adrienne D. Tanus, Isuta Nishio, Rhonda Williams, Janna Friedly, Bosco Soares, Derek Anderson, Jennifer Bambara, Timothy Dawson, Amy Hsu, Peggy Y. Kim, Daniel Krashin, Larissa Del Piero, Anna Korpak, Andrew Timmons, Pradeep Suri
Individual treatments for chronic low back pain (CLBP) have small magnitude effects. Combining different types of treatments may produce larger effects. This study used a 2×2 factorial randomized controlled trial (RCT) design to combine procedural and behavioral treatments for CLBP. The study aims were to: (1) assess feasibility of conducting a factorial RCT of these treatments; and (2) estimate individual
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EuroQol-5D-3L in Long Covid patients After Supplementation with EchA Marine®, a Sea Urchin Eggs Extract: a double-blinded, multicentrical study medRxiv. Pain Med. Pub Date : 2023-06-05 V Brichetti, T. Rubilar, J. Tejada, P. Montecino, A. Crespi-Abril, E Barbieri, N de la Rosa, J. Iriarte-Vazquez, N. Jajati, C. Volonteri, M. Sivori, G. de Larrañaga, F. Saldarini
Patients with Long COVID experience a significant decrease in their quality of life and the lack of effective treatment represents an unmet need in medical care and patient health. One proposed strategy for treating Long COVID is to increase the body’s ability to restore immune balance by controlling inflammation with anti-inflammatory substances. For this reason, the aim of this double-blind study
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The periaqueductal grey in chronic low back pain: dysregulated metabolites and function medRxiv. Pain Med. Pub Date : 2023-06-05 Laura Sirucek, Iara De Schoenmacker, Lindsay Gorrell, Robin Lütolf, Anke Langenfeld, Mirjam Baechler, Brigitte Wirth, Michèle Hubli, Niklaus Zölch, Petra Schweinhardt
Mechanisms underlying chronic pain are insufficiently understood. Preclinical evidence suggests a potential contribution of excitatory glutamatergic and inhibitory GABAergic imbalances in pain-relevant brain areas, such as a lower excitatory/inhibitory tone in the brainstem periaqueductal grey (PAG). This cross-sectional magnetic resonance spectroscopy (MRS) study investigated whether a lower excitatory/inhibitory
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A digital health intervention to support patients with chronic pain during prescription opioid tapering: a pilot randomised controlled trial medRxiv. Pain Med. Pub Date : 2023-05-11 Ali Gholamrezaei, Michael R Magee, Amy G McNeilage, Leah Dwyer, Alison Sim, Manuela L Ferreira, Beth D Darnall, Timothy Brake, Arun Aggarwal, Meredith Craigie, Irina Hollington, Paul Glare, Claire E Ashton-James
Introduction: Recent changes in opioid prescribing guidelines have led to an increasing number of patients with chronic pain being recommended to taper. However, opioid tapering can be challenging, and many patients require support.
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A text messaging intervention to support patients with chronic pain during prescription opioid tapering: protocol for a double-blind randomised controlled trial medRxiv. Pain Med. Pub Date : 2023-05-09 Ali Gholamrezaei, Michael R Magee, Amy G McNeilage, Leah Dwyer, Hassan Jafari, Alison Sim, Manuela L Ferreira, Beth D Darnall, Paul Glare, Claire E Ashton-James
Introduction Increases in pain and interference with quality of life is a common concern among people with chronic non-cancer pain (CNCP) who are tapering opioid medications. Research indicates that access to social and psychological support for pain self-management may help people to reduce their opioid dose without increasing pain and interference. This study evaluates the efficacy of a text messaging
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Counting your chickens before they hatch: improvements in an untreated chronic pain population, beyond regression to the mean and the placebo effect medRxiv. Pain Med. Pub Date : 2023-05-05 Monica Sean, Alexia Coulombe-Lévêque, William Nadeau, Anne-Catherine Charest, Marylie Martel, Guillaume Léonard, Pascal Tétreault
Background and aims Isolating the effect of an intervention from the natural course and fluctuations of a condition is a challenge in any clinical trial, particularly in the field of pain. Regression to the mean (RTM), wherein extreme scores are more likely to be followed by more average scores, may explain some of those observed fluctuations. However, while this phenomenon is relatively well-known
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Reduced Spinal Cord Gray Matter in Patients with Fibromyalgia Using Opioids Long-term medRxiv. Pain Med. Pub Date : 2023-05-02 Anne K. Baker, Su Hyoun Park, Kenneth A. Weber, Katherine T. Martucci
Objective Chronic pain involves alterations in brain gray matter volume (GMV). Moreover, opioid medications are known to reduce GMV in numerous brain regions involved in pain processing. However, no research has evaluated (1) chronic pain-related GMV alterations in the spinal cord or (2) the effect of opioids on spinal cord GMV. Accordingly, this study evaluated spinal cord GMV in health controls and
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Altered Functional Networks during Gain Anticipation in Fibromyalgia medRxiv. Pain Med. Pub Date : 2023-04-29 Su Hyoun Park, Andrew M. Michael, Anne K. Baker, Carina Lei, Katherine T. Martucci
Reward motivation is essential in shaping human behavior and cognition. Previous studies have shown altered reward motivation and reward brain circuitry in chronic pain conditions, including fibromyalgia. Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, cognitive problems, and mood-related symptoms. In this study, we analyzed brain reward networks in patients