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Tissue factor pathway inhibitor - cofactor-dependent regulation of the initiation of coagulation. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-08-27 Josefin Ahnström,Anastasis Petri,James Tb Crawley
PURPOSE OF REVIEW In humans, tissue factor pathway inhibitor (TFPI) exists in two alternatively spliced isoforms, TFPIα and TFPIβ. TFPIα consists of three Kunitz domains (K1, K2 and K3) and a highly basic C-terminal tail. K1 inhibits the tissue factor-activated factor VII complex, K2 specifically inhibits activated factor X, K3 is essential for interaction with its cofactor, protein S, and the basic
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Splenic filtration of red blood cells in physiology, malaria and sickle cell disease. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-08-27 Abdoulaye Sissoko,Yosra Ben Othmene,Pierre Buffet
PURPOSE OF REVIEW The human spleen clears the blood from circulating microorganisms and red blood cells (RBCs) displaying alterations. This review analyzes how generic mechanisms by which the spleen senses RBC, such pitting, trapping and erythrophagocytosis, impact the pathogenesis of twos major spleen-related diseases, malaria and sickle cell disease (SCD). RECENT FINDINGS Scintigraphy, functional
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Prophylactic red cell transfusions for sickle cell disease pregnancy: increased use of therapy could transform outcomes. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-08-15 Sheinei Alan,Deva Sharma,Lydia H Pecker
PURPOSE OF REVIEW Pregnancy for people with sickle cell disease (SCD) is high risk with persistently high rates of severe maternal and fetal mortality and morbidity. Transfusion therapy is the best-studied treatment for SCD in pregnancy; hydroxyurea is not usually used because of teratogenicity concerns. In high-resource settings, red cell transfusions are likely underutilized, while in low-resource
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Novel neutrophil biology insights underlying atypical chemokine receptor-1/Duffy antigen receptor of chemokines-associated neutropenia. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-07-25 Johnson M Liu, Hongbo R Luo
Atypical chemokine receptor-1 (ACKR1)/Duffy antigen receptor of chemokines (DARC)-associated neutropenia (ADAN; OMIM 611862), previously named benign ethnic neutropenia, and present in two-thirds of individuals identifying as Black in the USA, is associated with mild to moderate decreases in peripheral neutrophil counts that nevertheless do not lead to increased infections. Consequently, recent initiatives
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Unrelated hematopoietic stem cell donor registries: present reality and future prospects. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-07-22 Alexander H Schmidt
Stem cell donor registries play an important role in providing stem cell products from unrelated donors to patients with severe blood diseases. In this review, important aspects of donor registry work, current challenges and possible future developments are discussed.
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New insights of glycoprotein Ib-IX-V complex organization and glycoprotein Ibα in platelet biogenesis. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-07-17 Lulu Huang, Bojing Shao
Glycoprotein (GP) Ib-IX-V, a platelet surface receptor that plays a critical role in platelet adhesion and platelet-mediated immune responses, consists of GPIbα, GPIbβ, GPIX, and GPV in a stoichiometry of 2 : 4 : 2 : 1. Forming a complex is essential for GPIb-IX-V to function. GPIb-IX-V also plays an important role in platelet biogenesis by regulating the number and size of platelets. Yet how GPIb-IX-V
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Heme- and iron-activated macrophages in sickle cell disease: an updated perspective. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-07-17 Shobana Navaneethabalakrishnan, Xiuli An, Francesca Vinchi
Sickle cell disease (SCD) is a hereditary blood disorder due to a single-point mutation in the β-globin gene. The ensuing hemoglobin has the tendency to polymerize upon deoxygenation, leading to the typical sickle shape of red blood cells. While the primary pathology of sickle cell disease is a direct consequence of altered red blood cells, emerging evidence highlights the central role of macrophages
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Donor selection in allogeneic stem cell transplantation. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-07-16 Francisco Barriga, Alberto Cardoso Martins Lima
Recent progress in human leukocyte antigen (HLA) characterization, increased accrual of unrelated donors and cord blood units, and a new platform for haploidentical transplantation have resulted in the widespread availability of donors for allogeneic hematopoietic stem cell transplantation.
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Protease activated receptor-4: ready to be part of the antithrombosis spectrum. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-30 Izabella Andrianova, Mia Kowalczyk, Frederik Denorme
Cardiovascular disease is a major cause of death worldwide. Platelets play a key role in this pathological process. The serine protease thrombin is a critical regulator of platelet reactivity through protease activated receptors-1 (PAR1) and PAR4. Since targeting PAR4 comes with a low chance for bleeding, strategies blocking PAR4 function have great antithrombotic potential. Here, we reviewed the literature
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Histon activities in the extracellular environment: regulation and prothrombotic implications. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-27 Gwen M Keulen, Joram Huckriede, Kanin Wichapong, Gerry A F Nicolaes
Thromboembolic complications are a major contributor to global mortality. The relationship between inflammation and coagulation pathways has become an emerging research topic where the role of the innate immune response, and specifically neutrophils in "immunothrombosis" are receiving much attention. This review aims to dissect the intricate interplay between histones (from neutrophils or cellular
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Shedding light on GPIbα shedding. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-10 Caitlin Debaene, Hendrik B Feys, Katrijn R Six
Ectodomain shedding has been investigated since the late 1980s. The abundant and platelet specific GPIbα receptor is cleaved by ADAM17 resulting in the release of its ectodomain called glycocalicin. This review will address the role of glycocalicin as an end-stage marker of platelet turnover and storage lesion and will consider a potential function as effector in processes beyond hemostasis.
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Lipid mediators in neutrophil biology: inflammation, resolution and beyond. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-08 Anita Ghodsi, Andres Hidalgo, Stephania Libreros
Acute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a pivotal role in eradicating infectious pathogens, orchestrating the initiation and resolution of acute inflammation, and maintaining physiological functions. The resolution
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Platelet lipidomics and de novo lipogenesis: impact on health and disease. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-07 Laurence Pirotton, Emma de Cartier d'Yves, Luc Bertrand, Christophe Beauloye, Sandrine Horman
Lipids play vital roles in platelet structure, signaling, and metabolism. In addition to capturing exogenous lipids, platelets possess the capacity for de novo lipogenesis, regulated by acetyl-coA carboxylase 1 (ACC1). This review aims to cover the critical roles of platelet de novo lipogenesis and lipidome in platelet production, function, and diseases.
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Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor degradation. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-06 Hinde El Otmani, Karen Vanhoorelbeke, Claudia Tersteeg
Von Willebrand factor (VWF) plays a pivotal role in primary hemostasis. A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13 (ADAMTS13) is primarily responsible for cleaving ultra-large VWF multimers into smaller, less adhesive forms. However, plasmin has also been shown to cleave VWF multimers. This proteolytic cleavage of VWF results in a decreased multimer size and,
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The role of hematopoiesis in bone repair: an update. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-05-02 Elise C Jeffery
The repair of bone after injury requires the participation of many different immune cell populations, which are derived from the hematopoietic lineage. The field of osteoimmunology, or the study of the interactions between bone and the immune system, is a growing field with emerging impact on both the basic science and clinical aspects of fracture healing.
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The impact of obesity-induced inflammation on clonal hematopoiesis. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-04-22 Santhosh Kumar Pasupuleti, Reuben Kapur
This review meticulously delves into existing literature and recent findings to elucidate the intricate link between obesity and clonal hematopoiesis of indeterminate potential (CHIP) associated clonal hematopoiesis. It aims to enhance our comprehension of this multifaceted association, offering insights into potential avenues for future research and therapeutic interventions.
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Epigenetics of hematopoietic stem cell aging. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-04-15 Takako Yokomizo, Motohiko Oshima, Atsushi Iwama
The development of new antiaging medicines is of great interest to the current elderly and aging population. Aging of the hematopoietic system is attributed to the aging of hematopoietic stem cells (HSCs), and epigenetic alterations are the key effectors driving HSC aging. Understanding the epigenetics of HSC aging holds promise of providing new insights for combating HSC aging and age-related hematological
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The fulfilled promise and unmet potential of umbilical cord blood. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-04-05 James Ropa, Wouter Van't Hof
Here, we review classic and emerging uses of umbilical cord blood and highlight strategies to improve its utility, focusing on selection of the appropriate units and cell types for the intended applications.
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Transcription factor regulation of ribosomal RNA in hematopoiesis. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-04-03 Vikram R Paralkar
Ribosomal RNAs (rRNAs) are transcribed within nucleoli from rDNA repeats by RNA Polymerase I (Pol I). There is variation in rRNA transcription rates across the hematopoietic tree, and leukemic blast cells have prominent nucleoli, indicating abundant ribosome biogenesis. The mechanisms underlying these variations are poorly understood. The purpose of this review is to summarize findings of rDNA binding
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Desialylation by neuraminidases in platelets, kiss of death or bittersweet? Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-03-22 Nora Butta, Dianne E van der Wal
Loss of surface sialic acid by neuraminidases is known as 'desialylation'. Platelets are desialylated in bacterial or viral infections, during storage, senescence, various mutations, platelet auto antibodies, hemostasis and shear stress. In this review the recent literature on the different sialic acid capped glycan structures will be covered as well as platelet desialylation in inherited glycan disorders
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Pas de deux: the coordinated coupling of erythroid differentiation with the cell cycle. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-19 Merav Socolovsky
Recent work reveals that cell cycle duration and structure are remodeled in lock-step with distinct stages of erythroid differentiation. These cell cycle features have regulatory roles in differentiation, beyond the generic function of increasing cell number.
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Circulating endothelial cells in pathophysiology. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-16 Victor Emmanuel Brett, Francoise Dignat George, Chloe James
The purpose of this review is to synthesize recent insights into the roles and importance of circulating endothelial cells (CECs) as indicators of the severity, progression, and prognosis of vascular-related diseases.
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Generation of red blood cells from induced pluripotent stem cells. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-14 Naomi Gunawardena, Stella T Chou
Human induced pluripotent stem cells (iPSCs) are an attractive source to generate in-vitro-derived blood for use as transfusable and reagent red cells. We review recent advancements in the field and the remaining limitations for clinical use.
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Venous thromboembolism: diagnostic advances and unaddressed challenges in management. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-13 Rick Mathews, Monica T Hinds, Khanh P Nguyen
This review summarizes recent advances in developing targeted diagnostics for venous thromboembolism (VTE) and unaddressed knowledge gaps in patient management. Without addressing these critical data needs, the morbidity in VTE patients will persist.
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Developmental regulation of primitive erythropoiesis. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-12 Marlies P Rossmann, James Palis
In this review, we present an overview of recent studies of primitive erythropoiesis, focusing on advances in deciphering its embryonic origin, defining species-specific differences in its developmental regulation, and better understanding the molecular and metabolic pathways involved in terminal differentiation.
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Hematopoietic stem cell collection for sickle cell disease gene therapy. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-12 Alexis Leonard, Mitchell J Weiss
Gene therapy for sickle cell disease (SCD) is advancing rapidly, with two transformative products recently approved by the US Food and Drug Administration and numerous others under study. All current gene therapy protocols require ex vivo modification of autologous hematopoietic stem cells (HSCs). However, several SCD-related problems impair HSC collection, including a stressed and damaged bone marrow
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Macrocytic anemias. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-08 Mark J Koury, Daniel J Hausrath
Over the last century, the diseases associated with macrocytic anemia have been changing with more patients currently having hematological diseases including malignancies and myelodysplastic syndrome. The intracellular mechanisms underlying the development of anemia with macrocytosis can help in understanding normal erythropoiesis. Adaptations to these diseases involving erythroid progenitor and precursor
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Signaling networks guiding erythropoiesis. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-08 Shilpa Kuttikrishnan, Kirti S Prabhu, Abdul Q Khan, Shahab Uddin
Cytokine-mediated signaling pathways, including JAK/STAT, PI3K/AKT, and Ras/MAPK pathways, play an important role in the process of erythropoiesis. These pathways are involved in the survival, proliferation, and differentiation function of erythropoiesis.
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A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-02-07 Katsue Suzuki-Inoue, Nagaharu Tsukiji
Platelets are essential for hemostasis and are also vital in lymphatic and lung development and the maintenance of vascular integrity. Platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) and its endogenous ligand podoplanin (PDPN) in lymphatic endothelial cells (LECs) and other cells regulate these processes. This review aims to comprehensively summarize the roles of platelet CLEC-2
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microRNAs and thrombo-inflammation: relationship in sight. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-01-25 Sonia Aguila, Rocio Gonzalez-Conejero, Constantino Martinez
Thrombo-inflammation is a multifaceted pathologic process involving various cells such as platelets, neutrophils, and monocytes. In recent years, microRNAs have been consistently implicated as regulators of these cells.
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Vascular microphysiological systems. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2024-01-19 Sarah E Shelton
This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works.
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Age-related micro-environmental changes as drivers of clonal hematopoiesis. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-12-18 Tal Bacharach, Nathali Kaushansky, Liran I Shlush
Both aging and reduced diversity at the hematopoietic stem cells (HSCs) level are ubiquitous. What remains unclear is why some individuals develop clonal hematopoiesis (CH), and why does CH due to specific mutations occur in specific individuals. Much like aging, reduced diversity of HSCs is a complex phenotype shaped by numerous factors (germline & environment). The purpose of the current review is
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Disparities in acute myeloid leukemia treatments and outcomes. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-12-08 Ann-Kathrin Eisfeld
This review aims to summarize different contributors to survival disparities in acute myeloid leukemia (AML) patients. The focus is set on African-American (hereafter referred to as Black) patients, with separate consideration of self-reported race and ancestry. It aims to also highlight the interconnectivity of the different features that impact on despair survival.
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The future of HOXA-expressing leukemias: Menin inhibitor response and resistance. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-11-24 Daniela V Wenge, Scott A Armstrong
We provide an update on the successes and ongoing challenges of Menin inhibition as a novel approach for the treatment of patients with acute leukemias that express HOXA cluster genes including leukemias with KMT2A-rearrangements, NPM1 mutations or NUP98-rearrangements. Initial clinical trials show promising response rates in heavily pretreated patients suggesting these inhibitors may have a significant
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Pediatric acute myeloid leukemia - novel approaches. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-11-20 Seth E Karol,Gwenaelle Gueguen
PURPOSE OF REVIEW Despite higher remission and survival rates than observed in adults, children with acute myeloid leukemia (AML) still suffer unacceptably high rates of treatment failure and late toxicities. Ongoing work aims to improve these long-term outcomes through improvements in the utilization of current therapies, the incorporation of novel chemotherapy agents, and improved use of current
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The many faces of the megakaryocytes and their biological implications. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-11-01 Karen Guo,Kellie R Machlus,Virginia Camacho
PURPOSE OF REVIEW Single-cell RNA sequencing studies have revealed transcriptional heterogeneity within the megakaryocytic lineage and the identified unique subsets. In this review, we discuss the functional and phenotypic plasticity of these subpopulations as well as the impacts on health and disease. RECENT FINDINGS Megakaryocytes (MKs) can be transcriptionally categorized into platelet generating
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Platelet lifespan and mechanisms for clearance. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-10-30 Olga An,Carsten Deppermann
PURPOSE OF REVIEW Activated or aged platelets are removed from circulation under (patho)physiologic conditions, the exact mechanism of platelet clearance under such conditions remains unclear and are currently being investigated. This review focuses on recent findings and controversies regarding platelet clearance and the disruption of platelet life cycle. RECENT FINDINGS The platelet life span is
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Platelet mechanosensing as key to understanding platelet function. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-10-17 Ingmar Schoen, Martin Kenny, Smita Patil
This review highlights how the perception of platelet function is evolving based on recent insights into platelet mechanobiology.
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Modelling arterial thrombus formation in vitro. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-10-13 Amelia Drysdale, Azziza Zaabalawi, Sarah Jones
Models of arterial thrombus formation represent a vital experimental tool to investigate platelet function and test novel antithrombotic drugs. This review highlights some of the recent advances in modelling thrombus formation in vitro and suggests potential future directions.
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Factor XI as a therapeutic target in neuroinflammatory disease. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-09-06 Berk Taskin, Tia C L Kohs, Joseph J Shatzel, Cristina Puy, Owen J T McCarty
This review summarizes the pathophysiology and potential therapeutic options for treatment of multiple sclerosis, a common neuronal demyelinating disorder affecting 2.2 million people worldwide. As an autoimmune disorder, multiple sclerosis is associated with neuroinflammation and increased permeability of the blood-brain barrier (BBB), although the cause linking multiple sclerosis with compromised
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Mixed donor chimerism following stem cell transplantation for sickle cell disease. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-09-01 Niketa C Shah, Hemalatha G Rangarajan, Alexander Ngwube, Shalini Shenoy
Sickle cell disease is a debilitating hemoglobinopathy with high morbidity and mortality. Hematopoietic stem cell transplantation (HCT) is curative, but the presence of mixed donor/recipient chimerism post-HCT raises concerns about disease control long-term. Mixed donor/recipient chimerism is reported in significant numbers even after aggressive HCT conditioning regimens. Post-HCT, adequacy of donor
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The immunology of PF4 polyanion interactions. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-08-22 Anh T P Ngo, Veronica Bochenek, Kandace Gollomp
Platelet factor 4 (PF4, CXCL4), the most abundant α-granule platelet-specific chemokine, forms tetramers with an equatorial ring of high positive charge that bind to a wide range of polyanions, after which it changes conformation to expose antigenic epitopes. Antibodies directed against PF4 not only help to clear infection but can also lead to the development of thrombotic disorders such as heparin-induced
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Novel approaches to measure transfusion effectiveness. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-08-21 Marianne Elaine McPherson Yee, Ross M Fasano
This review encompasses different considerations of transfusion effectiveness based upon clinical scenario and transfusion indication. Tissue oxygenation, cerebral metabolic oxygen use, and red blood cell (RBC) survival are important elements of transfusion effectiveness in individuals with acute and chronic transfusion requirements.
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Inflammation and bone marrow fibrosis: novel immunotherapeutic targets. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-08-03 Francesca Rossella Calledda, Alessandro Malara, Alessandra Balduini
Myelofibrosis (MF) is primarily driven by constitutive activation of the Janus kinase/signal transducer of activators of transcription (JAK/STAT) pathway. While JAK inhibitors have shown to alleviate disease symptoms, their disease-modifying effects in MF are limited. The only curative treatment remains allogeneic stem cell transplantation, which can be applied to a minority of patients. As a result
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Red cell extracellular vesicles and coagulation activation pathways. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-08-03 Denis F Noubouossie, Nigel S Key
Packed red blood cells (PRBCs) are the most commonly transfused blood products. Preparation of PRBCs requires blood collection from donors, processing, and storage prior to transfusion to recipients. Stored red blood cells (RBCs) undergo structural and metabolic changes collectively known as the storage lesion. RBC extracellular vesicles (sREVs) are released in PRBC units during storage, and are transfused
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Switching and increasing prophylaxis regimen with a genetically recombinant fusion of coagulation factor IX and albumin in haemophilia B: a case report. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-7-31 María Teresa Álvarez-Román, Raquel Díaz Merchán, Roberto Carlos Raynero Mellado, Victor Jiménez-Yuste
We present a case of a boy diagnosed in 2007 with severe haemophilia B [factor IX (FIX) concentration < 1%] at age of 9 months. He was initially treated with recombinant FIX concentrates, but changes in regimens were frequent due to spontaneous hemarthros. In 2013, he entered a phase III trial (NCT01662531) and received rIX-FP, IDELVION at 50 IU/kg once a week. Although the boy was safely maintained
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Tissue factor positive microparticles as a biomarker for increased risk of breast cancer-associated thrombosis: a mini review. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-7-31 Regan Bucciol, Maha Othman
Cancer-associated thrombosis (CAT), such as venous thromboembolism (VTE), is a frequent complication in cancer patients, resulting in poor prognosis. Breast cancer is not highly thrombogenic but is highly prevalent, resulting in increased VTE cases. Many cancers express tissue factor (TF), a glycoprotein that triggers coagulation. The cancer cells were shown to express and release substantial amounts
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New insights into the glycobiology of immune thrombocytopenia. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-07-28 Katherine H Tiemeyer, David J Kuter, Christopher W Cairo, Marie A Hollenhorst
The platelet surface harbors a lush forest of glycans (carbohydrate polymers) attached to membrane proteins and lipids. Accumulating evidence suggests that these glycans may be relevant to the pathophysiology of immune thrombocytopenia (ITP). Here, we critically evaluate data that point to a possible role for loss of sialic acid in driving platelet clearance in ITP, comment on the potential use of
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Warm autoimmune hemolytic anemia: new insights and hypotheses. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-07-28 Donald R Branch
Warm autoimmune hemolytic anemia (wAIHA) is the most common of the immune hemolytic anemias. Although there are numerous case reports and reviews regarding this condition, some of the unusual and more recent findings have not been fully defined and may be contentious. This review will provide insight into the common specificity of the warm autoantibodies and hypothesize a novel mechanism of wAIHA,
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In-vivo functions and regulation of polyphosphate in the vascular system. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-07-18 Wen-Chan Huang, Reiner K Mailer, Thomas Renné
Polyphosphate, an inorganic polymer consisting of linearly linked phosphate subunits, is ubiquitously found in living organisms. Functions and regulation of the polymer have been analyzed in plants, bacteria and yeast; however, the roles of polyphosphate in mammals are still emerging.
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Platelet mitochondria: the mighty few. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-07-18 Abigail Ajanel, Robert A Campbell, Frederik Denorme
Platelet mitochondrial dysfunction is both caused by, as well as a source of oxidative stress. Oxidative stress is a key hallmark of metabolic disorders such as dyslipidemia and diabetes, which are known to have higher risks for thrombotic complications.
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The invisible string of coagulation, complement, iron, and inflammation in sickle cell disease. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-07-15 Joan D Beckman, Erica M Sparkenbaugh
This review provides an update on recent advances in mechanistic studies of thromboinflammatory mechanisms that contribute to the disease pathology in sickle cell disease (SCD). There is a focus on novel pathways, clinical relevance, and translational potential of these findings. We hope to encourage more advances in this area to reduce organ damage in young patients prior to gene therapy, and to serve
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The impact of prenatal inflammation on hematopoietic development. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-05-09 Nicole A Tseng,Anna E Beaudin
PURPOSE OF REVIEW Inflammation is now recognized as a major regulator of hematopoietic stem cell (HSC) function. Adult hematopoietic stem cells can adaptively modulate hematopoietic output in direct response to acute infection and inflammation. Conversely, prolonged exposure to inflammation can drive impaired HSC function, clonal expansion, and malignant transformation. As compared with adult hematopoiesis
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Interferon regulatory factor-8-dependent innate immune alarm senses GATA2 deficiency to alter hematopoietic differentiation and function. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-04-27 Kirby D Johnson,Mabel M Jung,Vu L Tran,Emery H Bresnick
PURPOSE OF REVIEW Recent discoveries have provided evidence for mechanistic links between the master regulator of hematopoiesis GATA2 and the key component of interferon and innate immunity signaling pathways, interferon-regulatory factor-8 (IRF8). These links have important implications for the control of myeloid differentiation in physiological and pathological states. RECENT FINDINGS GATA2 deficiency
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Crosstalk between terminal erythropoiesis and granulopoiesis within their common niche: the erythromyeloblastic island. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-04-25 Laurel Romano,Katie G Seu,Lionel Blanc,Theodosia A Kalfa
PURPOSE OF REVIEW The identity of the erythroblastic island (EBI) macrophage (Mϕ) has been under investigation for decades since it was recognized as the first hematopoietic niche 'nursing' terminal erythropoiesis. This review will focus on the current insights to the characteristics and the role of the EBI Mϕ balancing terminal erythropoiesis and granulopoiesis. RECENT FINDINGS While the EBI has long
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Deficits in our understanding of natural killer cell development in mouse and human. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-04-19 Christopher Schorr, Maya Shraddha Krishnan, Maegan Capitano
Natural killer (NK) cells are a type of immune cell that play a crucial role in the defense against cancer and viral infections. The development and maturation of NK cells is a complex process, involving the coordination of various signaling pathways, transcription factors, and epigenetic modifications. In recent years, there has been a growing interest in studying the development of NK cells. In this
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Understanding and targeting erythroid progenitor cells for effective cancer therapy. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-04-13 Qingfei Wang, Rylee A Poole, Mateusz Opyrchal
It is well described that tumor-directed aberrant myelopoiesis contributes to the generation of various myeloid populations with tumor-promoting properties. A growing number of recent studies have revealed the importance of the previously unappreciated roles of erythroid progenitor cells (EPCs) in the context of cancer, bringing the updated concept that altered erythropoiesis also facilitates tumor
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Regulation of granulocyte colony-stimulating factor-induced hematopoietic stem cell mobilization by the sympathetic nervous system. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-04-11 Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama
Granulocyte colony-stimulating factor (G-CSF) is now a standard agent to mobilize hematopoietic stem cells (HSCs) from the bone marrow to circulation. This review introduced mechanistic insights from the aspect of the sympathetic nervous system (SNS).
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Editorial: Current Opinion in Hematology: new editor announcement. Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-05-01 Sarah J Booth
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Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions Curr. Opin. Hematol. (IF 3.1) Pub Date : 2023-05-01 Rachel Josselsohn, Betsy J. Barnes, Theodosia A. Kalfa, Lionel Blanc
Purpose of review Terminal erythroid differentiation occurs in specialized niches called erythroblastic islands. Since their discovery in 1958, these niches have been described as a central macrophage surrounded by differentiating erythroblasts. Here, we review the recent advances made in the characterization of these islands and the role they could play in anaemia of inflammation. Recent findings