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Current state of gene therapy in sickle cell disease Vox Sang. (IF 2.7) Pub Date : 2024-03-15 Mei San Tang, Hua Shan
Sickle cell disease (SCD) is a type of hemoglobinopathy due to an autosomal recessive genetic defect, causing significant red cell sickling, multi‐organ damage and long‐term severe morbidities. Due to its complicated care and the impact on quality of life, a curative treatment for SCD is highly desirable. In recent years, gene therapy is emerging as a curative option for SCD, where autologous haematopoietic
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Limited evidence, lasting decisions: How voluntary non‐remunerated plasma donations can avoid the commercial one‐way street Vox Sang. (IF 2.7) Pub Date : 2024-03-14 Kelsey J. MacKay, Fritz Schiltz, Philippe Vandekerckhove
INTRODUCTION In July 2022, the European Commission published their proposal for a regulation on substances of human origin, which has since undergone debate [1]. The core of this debate surrounds whether or not the principle of voluntary non-remunerated donation (VNRD) should be loosened to increase the plasma supply in the European Union (EU). Based on the Committee of Ministers to Member States [2]
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Decreasing parvovirus B19 and hepatitis A nucleic acid test positivity rates in Canadian plasma donors following the initiation of COVID‐19 restriction in March 2020 Vox Sang. (IF 2.7) Pub Date : 2024-03-14 Steven J. Drews, Carmen Charlton, Sheila F. O'Brien, Samantha Burugu, Gregory A. Denomme
Background and ObjectivesIn Canada, plasma sent for fractionation is tested for both parvovirus B19 (B19V) and hepatitis A virus (HAV). This study compared positivity rates of B19 and HAV nucleic acid tests (NATs) in Canadian plasma samples for the pre‐COVID‐19 restriction era (2015 to end of February 2020 [Q1] 2020) and the post‐COVID‐19 restriction era.Materials and MethodsPooled EDTA plasma specimens
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Gender differences in scholarly productivity of early‐career transfusion medicine physicians Vox Sang. (IF 2.7) Pub Date : 2024-03-12 Tina S. Ipe, Yvette C. Tanhehco, Garrett S. Booth, Brian D. Adkins
Background and ObjectivesPromotion in academic medicine requires evidence of the creation and dissemination of scholarly output, primarily through peer‐reviewed publications. Studies demonstrate that scholarly activity and impact are lower for women physicians than for men physicians, especially during the early stages of their academic careers. This report reviewed physicians' academic productivity
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Has the frequency of ABO RhD blood groups in Australian blood donors changed as a result of the removal of the variant Creutzfeldt–Jakob disease‐based deferral? Vox Sang. (IF 2.7) Pub Date : 2024-03-07 Rena Hirani, Veronica C. Hoad, Iain B. Gosbell, David O. Irving
Background and ObjectivesUntil 25 July 2022, Australians who had spent more than 6 months in the United Kingdom or territories between 1980 and 1996 were deferred from blood donation due to the risk of variant Creutzfeldt–Jakob disease. Removal of this geography‐based donor deferral on RhD‐negative blood availability has not been reported.Materials and MethodsAll donors who donated at least once from
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RhD mismatch does not affect haematopoietic recovery, graft‐versus‐host disease and survival in allogeneic haematopoietic cell transplantation: A Japanese registry‐based study Vox Sang. (IF 2.7) Pub Date : 2024-03-01 Takaaki Konuma, Naoyuki Uchida, Wataru Takeda, Noriko Doki, Satoshi Yoshihara, Tetsuya Nishida, Takuro Kuriyama, Masatsugu Tanaka, Hiroyuki Ohigashi, Hirohisa Nakamae, Yuta Katayama, Shuichi Ota, Yoshiko Hashii, Fumihiko Ishimaru, Takahiro Fukuda, Marie Ohbiki, Yoshiko Atsuta
Background and ObjectivesABO blood group mismatch between the donor and the recipient can affect the success of the transplant as well as problems with the red blood cells during allogeneic haematopoietic cell transplantation (HCT). However, the impact of the Rhesus (Rh) D mismatch on transplant outcomes in allogeneic HCT has been poorly elucidated.Materials and MethodsWe retrospectively evaluated
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Stigmatizing deferrals disproportionally reduce donor return rates: Evidence from Brazil Vox Sang. (IF 2.7) Pub Date : 2024-03-01 Yan Vieites, Claudio M. Ferreira, Rafael Goldszmidt, Eduardo B. Andrade
Background and ObjectivesPrior research has shown that temporary deferrals negatively influence donor return rates, but it remains unknown the extent to which these effects vary across reasons for deferral. We investigate whether deferrals differ in their degree of perceived stigmatization and, if so, how being deferred for stigmatizing (vs. non‐stigmatizing) reasons affects subsequent donation behaviour
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Transfusion Camp Rwanda 2023: A train‐the‐trainer workshop establishing locally driven leadership in knowledge translation and sustainability in transfusion medicine education Vox Sang. (IF 2.7) Pub Date : 2024-03-01 Francoise Nizeyimana, Jacob Pendergrast, Angelique Ntegerejuwampayee, Yulia Lin, Aimable Kanyamuhunga, Christopher Gashaija, Florence Masaisa, Claudine Uzamukunda, Grace Mutuyimana, Fabrice Ndicunguye, Alexis Gaseminari, Bruce Mulindwa, Thomas Muyombo, Sophie Chargé, Teresa Skelton
Background and ObjectivesBlood transfusion is performed daily in hospitals. Gaps exist between transfusion guidelines and day‐to‐day clinical care. These gaps are prevalent in resource‐limited settings due to scarce continuing medical education. Transfusion Camp Rwanda aims to bridge this gap by (1) delivering context‐appropriate up‐to‐date education, (2) teaching participants how to independently
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Red cell concentrates from teen male donors contain poor‐quality biologically older cells Vox Sang. (IF 2.7) Pub Date : 2024-02-29 Olga Mykhailova, Mackenzie Brandon‐Coatham, Celina Phan, Mahsa Yazdanbakhsh, Carly Olafson, Qi‐Long Yi, Tamir Kanias, Jason P. Acker
Background and ObjectivesDonor factors influence the quality characteristics of red cell concentrates (RCCs) and the lesions that develop in these heterogeneous blood products during hypothermic storage. Teen male donors' RCCs contain elevated levels of biologically old red blood cells (RBCs). The aim of this study was to interrogate the quality of units of different donor ages and sexes to unravel
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Blood donation screening for hepatitis B virus core antibodies: The importance of confirmatory testing and initial implication for rare blood donor groups Vox Sang. (IF 2.7) Pub Date : 2024-02-29 Michael X. Fu, Jennifer Ingram, Courtney Roberts, Visa Nurmi, Emma Watkins, Nina Dempsey, Tanya Golubchik, Judith Breuer, Su Brailsford, William L. Irving, Monique Andersson, Peter Simmonds, Heli Harvala
Background and ObjectivesExclusion of blood donors with hepatitis B virus (HBV) core antibodies (anti‐HBc) prevents transfusion‐transmitted HBV infection but can lead to significant donor loss. As isolated anti‐HBc positivity does not always indicate true past HBV infection, we have investigated the effectiveness of confirmatory anti‐HBc testing and the representation of rare blood groups in anti‐HBc‐positive
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Evaluation of the impact of diagnostic blood loss and red blood cell transfusion in very‐low‐birth‐weight anaemic neonates during hospitalization: A multi‐centre retrospective clinical study Vox Sang. (IF 2.7) Pub Date : 2024-02-29 Ting Ma, Jiangcun Yang, Yang Sun, Aowei Song, Jin Zhang, Yuan Shen, Kai Hua, Wenjing Wu, Wei Chen
Background and ObjectivesDiagnostic blood loss is a significant factor in the development of anaemia in neonates with very low birth weight. This study aimed to assess the clinical efficacy of intervention approaches involving varying diagnostic blood loss and red blood cell transfusion volumes in neonates with very low birth weights experiencing anaemia during hospitalization.Materials and MethodsA
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Routine results of an algorithm for managing the production of blood components Vox Sang. (IF 2.7) Pub Date : 2024-02-27 Ana Isabel Pérez‐Aliaga, Irene Ayerra, Javier Sánchez‐Guillén, F. Javier López, Fernando Puente, Alfonso Aranda, José María Domingo, Carmen Garcés
Background and ObjectivesThe variability in the number of donations together with a growing demand for platelet concentrates and plasma‐derived medicines make us seek solutions aimed at optimizing the processing of blood. Some mathematical models to improve efficiencies in blood banking have been published. The goal of this work is to validate and evaluate an algorithm's impact in the production of
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International review of blood donation nucleic acid amplification testing Vox Sang. (IF 2.7) Pub Date : 2024-02-23 Helen M. Faddy, Carla Osiowy, Brian Custer, Michael Busch, Susan L. Stramer, Opeyemi Adesina, Thijs van de Laar, Wai-Chiu Tsoi, Claire Styles, Phil Kiely, Angelo Margaritis, So-Yong Kwon, Yan Qiu, Xuelian Deng, Antoine Lewin, Signe Winther Jørgensen, Christian Erikstrup, David Juhl, Silvia Sauleda, Bernardo Armando Camacho Rodriguez, Lisbeth Jennifer Catherine Soto Coral, Paula Andrea Gaviria García
Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion-transmitted infections. This project reviewed NAT for screening blood donations globally.
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Voluntary blood donation preferences in China: A discrete choice experiment among experienced and inexperienced donors Vox Sang. (IF 2.7) Pub Date : 2024-02-23 Chuqing Cao, Jing Wang, Tianyu Guo, Xinwen Hu, Bo Li, Caixia Wu, Zhong Liu, Stephen W. Pan
Background and ObjectivesDue partly to an ageing population, China faces an increasingly dire blood shortage crisis requiring greater voluntary blood donations. A better understanding of blood donation preferences can inform blood donation policies and potentially increase donations. We used an online survey and discrete choice experiment to achieve our study objective: identify the most influential
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A tight interplay between platelet activation and mitochondrial DNA release promotes platelet storage lesion in platelet concentrates Vox Sang. (IF 2.7) Pub Date : 2024-02-22 Kamand Haeri, Shahram Samiee, Peyman Beigi, Smerdis Hajati, Mohammad Reza Deyhim
Background and ObjectivesPlatelet storage lesion (PSL) adversely affects the quality of platelet concentrates (PCs). Platelets are prone to activation during storage. Moreover, elevated free mitochondrial DNA (mtDNA) levels in PCs are associated with a higher risk of adverse transfusion reactions. Therefore, we aimed to evaluate the correlation between platelet activation markers and mtDNA release
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Advancing gender inclusivity for Two-Spirit, trans, nonbinary and other gender-diverse blood and plasma donors Vox Sang. (IF 2.7) Pub Date : 2024-02-19 Jennie Haw, Terrie Butler-Foster, Benjamin Murray, Don Lapierre, Jesse Bosse, Jack Edwards, Şansal Gümüşpala, Catherine Jenkins, Aaron Devor
Two-Spirit, trans, nonbinary and other gender-diverse (2STGD) donors face challenges in donation. While many blood operators aim to address these challenges, to date, no empirical study with these donors has been conducted to guide their efforts. This paper reports 2STGD donors' views on a two-step approach asking donors their gender and sex assigned at birth (SAAB), and expanding gender options in
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Blood lactate after pre-hospital blood transfusion for major trauma by helicopter emergency medical services Vox Sang. (IF 2.7) Pub Date : 2024-02-15 Biswadev Mitra, Carly S. Talarico, Alexander Olaussen, David Anderson, Ben Meadley
The appropriate use of blood components is essential for ethical use of a precious, donated product. The aim of this study was to report in-hospital red blood cell (RBC) transfusion after pre-hospital transfusion by helicopter emergency medical service paramedics. A secondary aim was to assess the potential for venous blood lactate to predict ongoing transfusion.
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Trends in category and grade for therapeutic plasma exchange in the latest guideline on therapeutic apheresis by the American Society for Apheresis: Hurdles in pursuing evidence-based medicine Vox Sang. (IF 2.7) Pub Date : 2024-02-15 Han Joo Kim, Yousun Chung, Hyungsuk Kim, Sang-Hyun Hwang, Heung-Bum Oh, Dae-Hyun Ko
The Writing Committee of American Society for Apheresis released the ninth edition of guidelines for therapeutic apheresis in 2023. Categories have been a part of the guidelines since the first edition, and the grading system was introduced in the fifth edition, with updates in every new edition. In this study, we investigated the category and grade change trends through the latest five editions, focusing
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Evidence that CD36 is expressed on red blood cells and constitutes a novel blood group system of clinical importance Vox Sang. (IF 2.7) Pub Date : 2024-02-07 Abdul Ghani Alattar, Jill R. Storry, Martin L. Olsson
Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as blood groups and human platelet or neutrophil antigens. CD36 is widely considered a platelet antigen (Naka) and anti-CD36 can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) in CD36-negative pregnant women. CD36 is used as a marker of differentiation in early erythroid culture. During the
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The future of blood services amid a tight balance between the supply and demand of blood products: Perspectives from the ISBT Young Professional Council Vox Sang. (IF 2.7) Pub Date : 2024-01-25 Antoine Lewin, Eunike McGowan, Jian Ou-Yang, Lilian Antwi Boateng, Carla Luana Dinardo, Saikat Mandal, Nour Almozain, Jannison Ribeiro, Syeldy Langi Sasongko
Blood services manage the increasingly tight balance between the supply and demand of blood products, and their role in health research is expanding. This review explores the themes that may define the future of blood banking.
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End of selection criteria based on sexual orientation: An international symposium on alternatives to donation deferral Vox Sang. (IF 2.7) Pub Date : 2024-01-25 Antoine Lewin, Mindy Goldman, Michael P. Busch, Katy Davison, Thijs van de Laar, Pierre Tiberghien, Eilat Shinar, Sheila F. O'Brien, Gilles Lambert, Stephen Field, Tor Hervig, Darrell H. S. Tan, Brian Custer, Steven J. Drews, Marion C. Lanteri, Denis Klochkov, Eleonora Widmer, Marie-Pier Domingue, Christian Renaud, Marc Germain
Until recently, gay, bisexual and other men who have sex with men (MSM) were deferred from donating blood for 3–12 months since the last male-to-male sexual contact. This MSM deferral has been discontinued by several high-income countries (HIC) that now perform gender-neutral donor selection.
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Seroreactivity of antibodies to hepatitis B core antigen among hepatitis B surface antigen-screened negative blood donors and its implications for blood safety in a resource-constrained country Vox Sang. (IF 2.7) Pub Date : 2024-01-21 Rhoda T. Yu, Kenneth Aristotle P. Punzalan, Sonu Bhatnagar, Raymond B. Lutero, Iza Mae S. Chamen, Catherine B. Masangkay, Elizabeth Y. Arcellana-Nuqui
Transfusion-related hepatitis B infections have been reduced significantly with the implementation of blood screening using both serology and nucleic acid amplification technology (NAT) in developed countries. However, in resource-constrained countries, where NAT is inaccessible, the risk persists from early acute and occult cases. This study aimed to determine the antibodies to hepatitis B core antigen
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Novel missense mutation c.797T>C (p.Met266Thr) gives rise to the rare B(A) phenotype in a Chinese family Vox Sang. (IF 2.7) Pub Date : 2024-01-21 Lin-Nan Shao, Yi-Cheng Yang, Yue-Xin Xia, Chun-Xiang Li, Shi-Hang Zhou, Xiao-Hua Liang
B(A) phenotype is usually formed by nucleotide mutations in the ABO*B.01 allele, with their products exhibiting glycosyltransferases (GTs) A and B overlapping functionality. We herein report a B(A) allele found in a Chinese family.
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Incidence of formation of anti-D between patients with and without a history of solid organ transplant Vox Sang. (IF 2.7) Pub Date : 2024-01-21 Junaid Ahmad Wali, Mohamed Abdelmonem, AnhThu Nguyen, Hua Shan, Suchitra Pandey, Muharrem Yunce
Solid organ transplant surgeries including liver transplants constitute a substantial risk of bleeding complications and given frequent national blood shortages, supporting D-negative transplant recipients with D-negative red blood cell products perioperatively can be difficult for the transfusion services. This study was designed to compare the incidence of alloimmunization after D-mismatched red
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Clinical significance of decreased or loss of ABO blood group expression in acute myeloid leukaemia: A single-centre retrospective study Vox Sang. (IF 2.7) Pub Date : 2024-01-20 Jay Ho Han, Howon Lee, Jae Kwon Kim, Jaeeun Yoo, Kyuho Park, Dong Wook Jekarl, Yonggoo Kim
Decreased or loss of ABO blood group antigen expression has been observed in acute myeloid leukaemia (AML) patients. We studied the clinical significance of this group in AML patients.
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Development, implementation and impact of an immunoglobulin stewardship programme in Saskatchewan, Canada Vox Sang. (IF 2.7) Pub Date : 2024-01-17 Kinsuk Sarker, Jason R. Vanstone, Oluwaferanmi Adigun, Brad Boutilier, Jessica Comeau, Michelle L. Degelman, Paul Gottselig, Warren E. Berry, Ardyth Milne, Paula Van Vliet, Sheila Rutledge Harding
Intravenous immunoglobulin (IVIG) is one of the most costly and limited-supply blood products. Judicious use of this therapy is important to ensure a continued supply is available for patients in need. The Saskatchewan IG Stewardship Program was initiated to monitor and reduce inappropriate IG use.
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Novel regulatory variant in ABO intronic RUNX1 binding site inducing A3 phenotype Vox Sang. (IF 2.7) Pub Date : 2024-01-16 Gian Andri Thun, Morgan Gueuning, Sonja Sigurdardottir, Eduardo Meyer, Elise Gourri, Linda Schneider, Yvonne Merki, Nadine Trost, Kathrin Neuenschwander, Charlotte Engström, Beat M. Frey, Stefan Meyer, Maja P. Mattle-Greminger
Mixed-field agglutination in ABO phenotyping (A3, B3) has been linked to genetically different blood cell populations such as in chimerism, or to rare variants in either ABO exon 7 or regulatory regions. Clarification of such cases is challenging and would greatly benefit from sequencing technologies that allow resolving full-gene haplotypes at high resolution.
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Compliance of blood donors in Germany with non-sexual deferral criteria Vox Sang. (IF 2.7) Pub Date : 2024-01-16 Karina Preußel, Stefan Albrecht, Ruth Offergeld
In addition to mandatory testing of blood donations, the deferral of donors in the case of various sexual and non-sexual risk exposures ensures the safety of blood products in Germany. The study aimed to quantify non-disclosure of non-sexual risk exposures, as no data are available so far.
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The importance of confirmatory assays in testing blood donors for human T-cell lymphotropic virus Vox Sang. (IF 2.7) Pub Date : 2024-01-15 Marina Lobato Martins, Edel Figueiredo Barbosa-Stancioli, Maria Clara Fernandes da Silva-Malta, Sônia Mara Nunes
Serological HTLV-1/2 screening is mandatory for blood donor candidates in Brazil. Our objective was to analyse HTLV test results in blood donors submitted for screening and confirmatory assays in a Brazilian blood bank.
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X-ray irradiation effectively inactivated lymphocytes in transfusion in vivo monitored by the bioluminescence transfusion-associated graft-versus-host disease model Vox Sang. (IF 2.7) Pub Date : 2024-01-16 Dongxin Peng, Wenyuan Bai, Can Zhang, Xindai Chang, Ping Ma, Xiaohui Wang, Sujing Sun, Linsheng Zhan
Transfusion of cold-stored whole blood is the preferred resuscitation method for trauma patients but may cause transfusion-associated graft-versus-host disease (TA-GVHD). Standard clinical practice to prevent this is to irradiate blood components with gamma-rays. X-ray irradiations are also a safe and effective alternative to gamma-ray irradiation. We established a visual mouse model of TA-GVHD to
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The availability of plasma donors and plasma: A sociologist's perspective Vox Sang. (IF 2.7) Pub Date : 2024-01-16 Eva-Maria Merz
SOCIETAL AND SCIENTIFIC BACKGROUND Plasma donations are essential for producing plasma-derived medicinal products (PDMPs) to treat chronic diseases or critical conditions of patients [1]. As such, plasma is an important resource and brings health value to patients. Currently, about 35%–40% of the European plasma need is collected abroad, mostly in the USA from paid donors [2]. Due to current and emerging
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Patient-tailored platelet transfusion practices for children supported by extracorporeal membrane oxygenation Vox Sang. (IF 2.7) Pub Date : 2024-01-04 Ofer Schiller, Giulia Pula, Eran Shostak, Orit Manor-Shulman, Georgy Frenkel, Gabriel Amir, Joanne Yacobovich, Marianne E. Nellis, Ovadia Dagan
Extracorporeal membrane oxygenation (ECMO) serves as cardiopulmonary therapy in critically ill patients with respiratory/heart failure and often necessitates multiple blood product transfusions. The administration of platelet transfusions during ECMO is triggered by the presence or risk of significant bleeding. Most paediatric ECMO programmes follow guidelines that recommend a platelet transfusion
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Therapeutic efficacy and safety of pathogen-reduced platelet components: Results of a meta-analysis of randomized controlled trials Vox Sang. (IF 2.7) Pub Date : 2024-01-05 Joan Cid, Paola Charry, Miquel Lozano
Clinical efficacy and safety of pathogen-reduced platelet concentrates (PR-PCs) concerning bleeding prevention are still debated despite conclusive real-world data from multiple countries where PR-PCs are transfused routinely. We performed a meta-analysis of randomized controlled trials (RCTs) comparing the clinical efficacy and safety of conventional platelet components (PCs) and PR-PCs prepared with
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Development of multiplexed flow cytometry-based red blood cell antibody screen and identification assays Vox Sang. (IF 2.7) Pub Date : 2024-01-04 Robert Liwski, Anna Greenshields, Ian Grace, Calvino Cheng, Jason George Quinn
The purpose of this study was to develop a high-throughput method of performing red blood cell antibody screens and identification by utilizing flow cytometry and intracellular dyes to allow a multiplexed assay where three-cell screens can be performed in a single test well and 11-cell panels in three test wells.
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The evolution and interpretation of seroprevalence of SARS-CoV-2 antibodies among South African blood donors from the Beta to Omicron variant-driven waves Vox Sang. (IF 2.7) Pub Date : 2023-12-29 Marion Vermeulen, Laurette Mhlanga, Wendy Sykes, Russell Cable, Charl Coleman, Nadia Pietersen, Ronel Swanevelder, Tanya Nadia Glatt, Jeremy Bingham, Karin van den Berg, Eduard Grebe, Alex Welte
Confirmed COVID-19 diagnoses underestimate the total number of infections. Blood donors can provide representative seroprevalence estimates, which can be leveraged into reasonable estimates of total infection counts and infection fatality rate (IFR).
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Development and validation of a scoring system to predict vasovagal reaction upon whole-blood donation Vox Sang. (IF 2.7) Pub Date : 2023-12-29 Tatsuma Hashizume, Gaku Kondo, Fumihiko Ishimaru, Yoko Ikeda, Keiko Kagawa, Noriko Kunii, Noriko Namba, Kiichi Aoki, Yoshihiro Sawamura, Shigeyoshi Makino
Risk factors for vasovagal reaction (VVR) have been extensively studied. With knowledge of the relative importance of these risk factors for VVR, collection staff could take care of blood donors from the same standpoint, leading to improved donor safety. We therefore developed a scoring system to predict VVR, which incorporates registration information.
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An interesting case of isolated false-negative hepatitis B surface antigen in a blood donor Vox Sang. (IF 2.7) Pub Date : 2023-12-29 Nevenka Bujandric, Jasmina Grujic, Mirjana Krga Milanovic
An important requirement for a hepatitis B surface antigen (HBsAg) screening assay is reliable detection of HBsAg mutant forms, especially in blood donation. Here we investigate and describe the case of an isolated false-negative result of commercial serology HBsAg screening assay of a blood donor.
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Notification and follow-up of blood donors reactive for transfusion-transmitted infections: A narrative review of the literature from India Vox Sang. (IF 2.7) Pub Date : 2023-12-29 Rahul Chaurasia, Gopal Kumar Patidar, Hem Chandra Pandey, Radheshyam Meher
Notifying blood donors of their reactive status for transfusion-transmitted infections (TTIs) plays a vital role in enabling early diagnosis and management while also preventing these donors from making future donation and transmission of the infectious agent. Given the limited data on donor notification processes in India, a narrative review was conducted to assess the existing notification process
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Using competition for plasma donor recruitment and retention: An Australian university case study Vox Sang. (IF 2.7) Pub Date : 2023-12-29 Jack Bryant, Torres Woolley, Tarun Sen Gupta, Kathleen Chell
Using evidence from one Australian university's participation in the Vampire Cup (an 8-week national inter-university blood donation competition), this study aimed to (1) understand important motivators and successful promotional strategies driving engagement in the competition, and (2) determine the impact of competition on the recruitment and retention of young adult plasma donors.
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Risk prediction of iron deficiency for plasmapheresis donors in China: Development and validation of a prediction model Vox Sang. (IF 2.7) Pub Date : 2023-12-28 Guanglin Xiao, Changqing Li, Yongjun Chen, Peizhe Zhao, Wan Li, Hanzu Xiao, Yating Yang, Yu Zhang, Rong Zhou, Aying Liu, Lili Liu, Linzhi Du, Qian Xiang, Jing Yang, Ya Wang
The present study aims to evaluate the iron stores in plasmapheresis donors and develop and validate an iron deficiency (ID) risk prediction model for plasmapheresis donors with potential or existing ID.
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Implementation of amotosalen plus ultraviolet A-mediated pathogen reduction for all platelet concentrates in France: Impact on the risk of transfusion-transmitted infections Vox Sang. (IF 2.7) Pub Date : 2023-12-28 Pascale Richard, Elodie Pouchol, Imad Sandid, Laurent Aoustin, Caroline Lefort, Anne-Gaële Chartois, Alexis Baima, Lucile Malard, Caroline Bacquet, Virginie Ferrera-Tourenc, Pierre Gallian, Syria Laperche, Cathy Bliem, Pascal Morel, Pierre Tiberghien
Pathogen reduction (PR) technology may reduce the risk of transfusion-transmitted infections (TTIs), notably transfusion-transmitted bacterial infection (TTBI) associated with platelet concentrates (PCs). PR (amotosalen/UVA treatment) was implemented for all PCs transfused in France in November 2017. No bacterial detection was in place beforehand. The study aimed to assess the impact of PR PC on TTI
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Hepatitis B virus genotype surveillance in Canadian blood donors and a referred patient population, 2016–2021 Vox Sang. (IF 2.7) Pub Date : 2023-12-23 Carla Osiowy, Elizabeth Giles, Christopher F. Lowe, Nancy Matic, Donald G. Murphy, Samra Uzicanin, Steven J. Drews, Sheila F. O'Brien
Hepatitis B virus (HBV) genotypes (A–H) have a distinct geographic distribution and are highly associated with the country of birth. Canada has experienced increased immigration over the past decade, primarily from regions where HBV is endemic. This study investigated the proportions and trends of HBV genotypes within blood donor and clinical populations of Canada over the period 2016–2021.
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The selection and preparation of red cell components for intrauterine transfusion: A national survey Vox Sang. (IF 2.7) Pub Date : 2023-12-23 Melanie Bodnar, Lani Lieberman, Valerie Arsenault, Philip Berardi, Jennifer Duncan, Debra Lane, Marianne Lavoie, Joanna McCarthy, Douglas Morrison, Nancy Robitaille, Nadine Shehata, Ann Wilson, Gwen Clarke
The practice regarding the selection and preparation of red blood cells (RBCs) for intrauterine transfusion (IUT) is variable reflecting historical practice and expert opinion rather than evidence-based recommendations. The aim of this survey was to assess Canadian hospital blood bank practice with respect to red cell IUT.
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Haemovigilance resources available for everyone: A report from the International Haemovigilance Tools Collaborative Project Vox Sang. (IF 2.7) Pub Date : 2023-12-21 Mary Townsend, Yuyun S. Maryuningsih Soedarmono, Shruthi Narayan, Paul Ashford, Erica M. Wood, Barbee I. Whitaker
Haemovigilance systems are intended to collect and analyse data, and report findings relating to transfusion complications, such as blood product safety, procedural incidents, and adverse reactions in donors and patients. A common problem among developing haemovigilance programs is the lack of resources and tools available to countries striving to establish or enhance their haemovigilance system.
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A case of haemolytic disease of the fetus and newborn attributed to a novel antigen in the RHAG blood group system Vox Sang. (IF 2.7) Pub Date : 2023-12-14 Saion Chatterjee, Glenda Millard, Suwat Chiawchan, Sarawan Chanthet, James Daly, Catherine Hyland, Pimpin Kitpoka, Tanya Powley, Yew-Wah Liew
A newborn presented with jaundice in Thailand. The cord red cells tested positive by direct antiglobulin test (DAT) for an unknown maternal red cell antibody. Initial blood group sequencing suggested that the infant carried a novel variant RHAG c.140T>C, responsible for a low-prevalence antigen in the RHAG blood group system (ISBT 030). We report here on testing of samples from the infant's parents
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Virtual platelet cross-matching as transfusion management for patients with immune platelet refractoriness Vox Sang. (IF 2.7) Pub Date : 2023-12-05 Carolina Bonet-Bub, Bruna Paccola Blanco, Thais Carvalho de Oliveira, Tamiris Baptista Sampaio, Itala Gomes, Valeria de Freitas Dutra, Thiago Henrique Costa, José Mauro Kutner
This study describes the use of the Epvix platform for virtual cross-matching (VC) of human leucocyte antigen (HLA)-compatible platelets for patients with immune platelet refractoriness, and demonstrates effectiveness of the selected platelets.
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Challenges associated with access to plasma-derived medicinal products in low middle-income and low-income countries Vox Sang. (IF 2.7) Pub Date : 2023-12-05 Magdy El Ekiaby, Saliou Diop, Emna Gouider, Faten Moftah
Plasma-derived medicinal products (PDMPs) are essential to treat many chronic conditions such as haemophilia and primary immunodeficiency. Patients living in low middle-income and low-income countries (LMICs and LICs, respectively) have limited access to PDMPs. The aim of this article is to explore the challenges of accessing PDMPs in LMICs and LICs.
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Towards standardized human platelet lysate production in Europe: An initiative of the European Blood Alliance Vox Sang. (IF 2.7) Pub Date : 2023-12-04 Dirk De Korte, Willem Delabie, Hendrik B. Feys, Thomas Klei, Rune Larsen, Ólafur Sigurjónsson, Ana Paula Sousa
Human platelet lysate (hPL) is a supplement for cell culture media that can be derived from platelet concentrates. As not-for-profit blood establishments, we endorse the evolution of maximally exploiting the potential of donated blood and its derived components, including platelets. The decision to use platelet concentrates to supply hPL as a cell culture supplement should align with the principles
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Standardized electronic messages to enhance communication in transfusion and transplantation Vox Sang. (IF 2.7) Pub Date : 2023-12-04 Karen Moniz, Paul Ashford
Blood transfusion was one of the earliest fields in healthcare to introduce electronic transfer of information using barcodes on blood product labels. It had been recognized that errors made during the manual recording and transcription of information were a significant avoidable risk in blood transfusion that could be addressed through automation. The first barcodes were used in 1976 in a test programme
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The value of genetic data from 665,460 individuals in managing iron deficiency anaemia and suitability to donate blood Vox Sang. (IF 2.7) Pub Date : 2023-11-28 Jarkko Toivonen, Elias Allara, , Johanna Castrén, Emanuele di Angelantonio, Mikko Arvas
Although the genetic determinants of haemoglobin and ferritin have been widely studied, those of the clinically and globally relevant iron deficiency anaemia (IDA) and deferral due to hypohaemoglobinemia (Hb-deferral) are unclear. In this investigation, we aimed to quantify the value of genetic information in predicting IDA and Hb-deferral.
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New plasma protein C and protein S concentrate: A synergy for therapeutic purposes Vox Sang. (IF 2.7) Pub Date : 2023-11-28 Filippo Mori, Cristina Angelini, Claudio Farina
Deficiencies of protein C (PC) or protein S (PS) are rare diseases, characterized by mutations in the PC or PS genes, which encode plasma serine proteases with anti-coagulant activity. Severe PC or PS deficiencies manifest in early life as neonatal purpura fulminans, a life-threatening heamorrhagic condition requiring immediate treatment. First-line treatment involves replacement therapy, followed
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Effects of plasmapheresis frequency on health status and exercise performance in men: A randomized controlled trial Vox Sang. (IF 2.7) Pub Date : 2023-11-24 Alexandre Mortier, Jina Khoudary, Sophie van Dooslaer de Ten Ryen, Camille Lannoy, Nicolas Benoit, Nancy Antoine, Sylvie Copine, Hans Van Remoortel, Philippe Vandekerckhove, Veerle Compernolle, Louise Deldicque
Most research studies on the effects of repeated plasma donation are observational with different study limitations, resulting in high uncertainty on the link between repeated plasma donation and health consequences. Here, we prospectively investigated the safety of intensive or less intensive plasma donation protocols.
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Safeguarding plasma for fractionation: How can we deal with operational challenges in European Union countries Vox Sang. (IF 2.7) Pub Date : 2023-11-20 Willem Martin Smid, Daphne C. Thijssen-Timmer
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
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Factors related to the development of high antibody titres against SARS-CoV-2 in convalescent plasma donors from the ConPlas-19 trial Vox Sang. (IF 2.7) Pub Date : 2023-11-20 Irene Romera Martínez, Cristina Avendaño-Solá, Carolina Villegas Da Ros, Alba Bosch Llobet, José Antonio García Erce, María Isabel González Fraile, Luisa Guerra Domínguez, Isabel Vicuña Andrés, Javier Anguita Velasco, Victoria Paz González Rodríguez, Enric Contreras, Sabin Urcelay Uranga, Ángel Luis Pajares Herraiz, Teresa Jimenez-Marco, Ana María Ojea Pérez, José Luis Arroyo Rodríguez, Mayte Pérez-Olmeda
The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas-19 donors and characteristics that associate with high anti-SARS-CoV-2 antibody levels.
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International Forum on Blood Donation in Individuals with Current, Past or Germline Predisposition to Malignancy: Responses. Vox Sang. (IF 2.7) Pub Date : 2023-11-15 Diva Baggio,Lucy C Fox,Erica M Wood,Robby Nur Aditya,Mindy Goldman,Karin van den Berg,Sabine Kayser,Patrick Wuchter,Noriko Namba,Nelson H Tsuno,Shigeyoshi Makino,Cheuk Kwong Lee,Naim Akhtar,Farrukh Shah,Gail Miflin,Daniele Prati,Massimo La Raja,Ursula La Rocca,Pascale Richard,Pierre Tiberghien,Robert J Harley,May Y Raouf,Ranjita Sharma,Suminder Kaur,Sanne Bruijns,Henriette Prakke-Weekamp,Nancy Dunbar
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International Forum on Blood Donation in Individuals with Current, Past or Germline Predisposition to Malignancy: Summary. Vox Sang. (IF 2.7) Pub Date : 2023-11-15 Diva Baggio,Lucy C Fox,Erica M Wood,Robby Nur Aditya,Mindy Goldman,Karin van den Berg,Sabine Kayser,Patrick Wuchter,Noriko Namba,Nelson H Tsuno,Shigeyoshi Makino,Cheuk Kwong Lee,Naim Akhtar,Farrukh Shah,Gail Miflin,Daniele Prati,Massimo La Raja,Ursula La Rocca,Pascale Richard,Pierre Tiberghien,Robert J Harley,May Y Raouf,Ranjita Sharma,Suminder Kaur,Sanne Bruijns,Henriette Prakke-Weekamp,Nancy Dunbar
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The role of CD36 antibodies in haematopoietic stem cell transplantation Vox Sang. (IF 2.7) Pub Date : 2023-11-13 Nelson H. Tsuno, Miquel Lozano
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.