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Regular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donors in Australia Vox Sang. (IF 1.8) Pub Date : 2024-09-20 Md Morshadur Rahman, Andrew Hayen, John K. Olynyk, Anne E. Cust, David O. Irving, Surendra Karki
Background and ObjectivesSeveral studies have suggested that blood donors have lower risk of gastrointestinal and breast cancers, whereas some have indicated an increased risk of haematological cancers. We examined these associations by appropriately adjusting the ‘healthy donor effect’ (HDE).Materials and MethodsWe examined the risk of gastrointestinal/colorectal, breast and haematological cancers
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Extending the post‐thaw shelf‐life of cryoprecipitate when stored at refrigerated temperatures Vox Sang. (IF 1.8) Pub Date : 2024-09-19 Kelly M. Winter, Rachel G. Webb, Eugenia Mazur, Peta M. Dennington, Denese C. Marks
Background and ObjectivesThe post‐thaw shelf‐life of cryoprecipitate is 6 h, leading to high wastage. Storage of thawed cryoprecipitate at refrigerated temperatures may be feasible to extend the shelf‐life. This study aimed to evaluate the quality of thawed cryoprecipitate stored at 1–6°C for up to 14 days.Materials and MethodsCryoprecipitate (mini‐ and full‐size packs derived from both apheresis and
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Autoantibodies to ADAMTS13 in human immunodeficiency virus‐associated thrombotic thrombocytopenic purpura Vox Sang. (IF 1.8) Pub Date : 2024-09-19 Muriel Meiring, Mmakgabu Khemisi, Susan Louw, Palanisamy Krishnan
Background and ObjectivesThrombotic thrombocytopenic purpura (TTP) is a potentially fatal thrombotic microangiopathic disorder that can result from human immunodeficiency virus (HIV) infection. The pathogenesis involves a deficiency of the von Willebrand factor (vWF) cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motifs member 13) and the presence of anti‐ADAMTS13
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The prevalence of hepatitis B virus, human T‐lymphotropic virus and human immunodeficiency virus in patients receiving blood transfusions in South Africa Vox Sang. (IF 1.8) Pub Date : 2024-09-11 Reynier J. Willemse, Christa J. Grobler, Edward L. Murphy, Nareg Roubinian, Charl Colemen, Solly Machaba, Marion Vermeulen
Background and ObjectivesSouth Africa has a high prevalence of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and to a lesser extent human T‐lymphotropic virus (HTLV). Each of these agents is transfusion‐transmissible (TT) but deciding whether to implement preventive screening depends upon knowledge of background prevalence in transfused patients. We determined the prevalence of HIV
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A comprehensive approach to continuous quality improvement of massive transfusion by developing key performance indicators Vox Sang. (IF 1.8) Pub Date : 2024-09-10 Ancy Ninan, Vimal Krishnan, Shamee Shastry, Ganesh Mohan, Deepika Chenna, Deep Madkaiker, Jayaraj Mymbilly Balakrishnan
Background and ObjectivesTo develop key performance indicators (KPI) for use in quality assessment of our institutional goal‐directed massive transfusion (GDMT).Materials and MethodsA team comprising our transfusion and emergency medicine departments carried out a cross‐sectional data analysis of GDMT in adult patients from January 2021 to December 2022. The study was rooted in the Define, Measure
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The efficacy and effectiveness of drinking interventions to reduce vasovagal reactions in blood donors: A systematic review and meta‐analysis Vox Sang. (IF 1.8) Pub Date : 2024-09-06 Hans Van Remoortel, Dieter Van de Sande, Dieter Maes, Jina Khoudary, Veerle Tavernier, Pierre Tiberghien, Emmy De Buck, Veerle Compernolle
Background and ObjectivesBlood establishments strive to ensure the safety and comfort of blood donors while minimizing adverse events. This review aims to assess the efficacy and effectiveness of eating and/or drinking interventions before, during and/or after blood donation in reducing vasovagal reactions (VVRs).Materials and MethodsWe analysed randomized and non‐randomized controlled trials comparing
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The prototypical UK blood donor, homophily and blood donation: Blood donors are like you, not me Vox Sang. (IF 1.8) Pub Date : 2024-09-03 Eamonn Ferguson, Sarah Bowen, Richard Mills, Claire Reynolds, Katy Davison, Claire Lawrence, Roanna Maharaj, Chris Starmer, Abigail Barr, Tracy Williams, Mark Croucher, Susan R. Brailsford
Background and ObjectivesHomophily represents the extent to which people feel others are like them and encourages the uptake of activities they feel people like them do. Currently, there are no data on blood donor homophily with respect to (i) people's representation of the average prototypical UK blood donor and (ii) the degree of homophily with this prototype for current donors, non‐donors, groups
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Is it useful to wash stored red blood cells in cardiopulmonary bypass priming fluid for neonatal cardiac surgery? A single‐centre retrospective study Vox Sang. (IF 1.8) Pub Date : 2024-09-03 He Wang, Yu Jin, Peng Gao, Jia Liu, Wenting Wang, Peiyao Zhang, Jinping Liu
Background and ObjectivesNeonatal cardiac surgery requires careful consideration of cardiopulmonary bypass (CPB) priming fluid composition due to small blood volume and immature physiology. This study investigated the impact of allogeneic stored red blood cells (RBCs) processed using an autotransfusion system in CPB priming fluid for neonates.Materials and MethodsWe compared perioperative parameters
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Impact of recent criteria changes for the deferral criteria specific to men who have sex with men in France Vox Sang. (IF 1.8) Pub Date : 2024-09-01 Claire Sauvage, S. Laperche, V. Corominas, K. Stefic, S. Le Cam, É. Pouchol, P. Morel, P. Tiberghien, F. Lot
Background and ObjectivesIn 2016, France allowed men who have sex with men (MSM) to donate blood if they had not had sex with men in the previous 12 months. In April 2020, this restriction was relaxed to 4 months due to the lack of negative impact observed on blood safety. This study assesses the impact of reducing this deferral period on epidemiological surveillance indicators.Materials and MethodsThis
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Blood donor questionnaires and infectious disease screening in Latin American countries Vox Sang. (IF 1.8) Pub Date : 2024-08-29 Gisela Marrero‐Rivera, Michel‐Andrés García‐Otálora, Carlos Gonzalez, José Pérez‐Carrillo, Paolo Rojas, Paula Castellanos, Melissa Granados, Guillermo Herrera, Celina Montemayor, Sara Bakhtary
Background and ObjectivesBlood donor questionnaires are tools used to screen prospective blood donors to determine their eligibility. There are limited data regarding blood donor questionnaires and infectious disease screening of the blood supply in Latin American countries. This study aimed to survey donor centres in Latin American countries to learn more about blood donor screening and infection
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The association between attitude towards facemasks, quality of donation experience and relationship with healthcare providers: A cross‐sectional exploratory study Vox Sang. (IF 1.8) Pub Date : 2024-08-26 Marco Bani, Stefano Ardenghi, Selena Russo, Federico Zorzi, Giulia Rampoldi, Alexia Del Greco, Alessandra Caputo, Barbara Giussani, Erica Magri, Maria Grazia Strepparava
Background and ObjectivesFacemasks represent an essential measure of prevention against the spread of infectious diseases; however, they lessen the ability to convey and understand emotions through facial expressions. In blood donation settings, facemask wearing could interfere with professionals' tasks, reduce the satisfaction of blood donors and affect their future blood donation behaviour. This
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Use of preoperative erythropoietin‐stimulating agents is associated with decreased thrombotic adverse events compared to red blood cell transfusion in surgical patients with anaemia Vox Sang. (IF 1.8) Pub Date : 2024-08-22 Una E. Choi, Ryan C. Nicholson, Steven M. Frank, Stephanie Cha, Brian C. Cho, Jennifer S. Lawton, Laeben C. Lester, Nadia B. Hensley
Background and ObjectivesPreoperative red blood cell (RBC) transfusions increase post‐operative venous thromboembolic (VTE) events. Erythropoietin‐stimulating agents (ESAs) increase VTE risk in cancer patients; we aimed to assess ESA versus RBC‐associated VTE risks in a broad population of surgical patients.Materials and MethodsWe queried TriNetX Diamond Network from 2006 to 2023, comparing patients
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A novel cisAB allele with a missense variant (c.971T>C) in the ABO gene of a Brazilian family Vox Sang. (IF 1.8) Pub Date : 2024-08-22 Marcos Paulo Miola, Caroline Luise Prochaska, Guilherme Cardoso, Octávio Ricci Junior, Luiz Carlos de Mattos
Background and ObjectivesMissense variants in exon 7 of the ABO gene can lead to the formation of cisAB alleles. These alleles encode glycosyltransferases (GTs) capable of synthesizing both A and B antigens. In this study, we report the discovery of a novel cisAB allele and characterize it at molecular, protein and serological levels.Materials and MethodsBlood and DNA samples from the proband and seven
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Navigating the Asia‐Pacific region plasma therapies landscape: Insights from the 2023 Asia‐Pacific Plasma Leaders' Network meetings Vox Sang. (IF 1.8) Pub Date : 2024-08-20 Sonu Bhatnagar, Thierry Burnouf, Johan Prevot, Jean‐Claude Faber, René Büechel, Yuyun Siti Maryuningsih, Bach Quoc Khanh, Nguyen Thi Mai, Hideo Nakanishi, Masako Kataoka
The Asia‐Pacific Plasma Leaders' Network (APPLN) plays a crucial role in addressing the regional shortage of plasma‐derived medicinal products (PDMPs), particularly in low‐ and middle‐income countries (LMICs). It provides a platform for experts to share their expertise and drive multi‐stakeholder collaborations. While several PDMPs are acknowledged by the World Health Organization (WHO) as life‐saving
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Biological impact of manual blood exchange in malignant Bordetella pertussis infection in infants Vox Sang. (IF 1.8) Pub Date : 2024-08-14 Vladimir L. Cousin, Caroline Caula, Pierre Tissières
Background and ObjectivesManual blood exchange (MBE) is a leukoreduction therapy for hyperleukocytosis in Bordetella spp. infection. We describe the impact of BE on clinical and biological parameters in critically ill children with malignant pertussis.Materials and MethodsThis is a monocentric retrospective review of patients with malignant pertussis infection treated with MBE. It describes the evolution
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Detecting serologically difficult ABO blood groups using single‐molecule real‐time sequencing technology Vox Sang. (IF 1.8) Pub Date : 2024-08-14 Zhe Wang, Yushuang Chu, Yanlin Xiao, Maohong Bian
Background and ObjectivesRecently, third‐generation long‐read sequencing technology has been increasingly applied to the detection of various blood group systems. Because of its long read length and use of single‐molecule sequencing, it is capable of obtaining the sequences of blood group genes in their entirety as well as of distinguishing haplotypes. Therefore, here, we collected ABO blood group
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Repeated apheresis donations cause important iron deficiency in male Japanese donors Vox Sang. (IF 1.8) Pub Date : 2024-08-13 Takeshi Odajima, Nelson H. Tsuno, Junko Iwasaki, Koji Matsuzaki, Fumihiko Ishimaru, Rie Okubo, Junko Murakami, Kaori Kitsukawa, Katsuya Ikuta, Kazuo Muroi, Masahiro Satake, Shuichi Kino
Background and ObjectivesIn Japan, apheresis donation of plasma is allowed to a maximum of 24 times a year, and plateletpheresis are counted as two plasmapheresis donations. Diversion of the initial blood flow is conducted for all donations, and additionally, blood remaining in apheresis machine circuit is lost. Here, we aimed to investigate on the health impact of frequent apheresis donations, as
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Plasma‐derived product recipients' views on the acceptability of implementing a programme of plasma donation for fractionation from men who have sex with men Vox Sang. (IF 1.8) Pub Date : 2024-08-01 Justine Benoit, Jessica Caruso, Marc Germain, Geneviève Myhal, Ken Monteith, Joanne Otis
Background and ObjectivesOver the past few years in Québec, Canada, exclusion criteria for blood donation and plasma donation for fractionation have been modified. Héma‐Québec, the institution responsible for blood products, has made changes to allow more inclusive access to blood and plasma donation, in accordance with evolving scientific data concerning donation safety. The study, conducted before
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The International Society of Blood Transfusion (ISBT) Public Health Research Toolkit: A report from the Surveillance, Risk Assessment and Policy Sub-group of the ISBT Transfusion Transmitted Infectious Diseases Working Party. Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Jean Stanley,Michael P Busch,Christian Erikstrup,Susan A Galel,Jerry A Holmberg,Antoine Lewin,Sheila F O'Brien,Carla Osiowy,Gopal Patidar,W Alton Russell,Bryan R Spencer,Connie Higgs,
BACKGROUND AND OBJECTIVES Data provided from blood donors have contributed to the understanding of public health epidemiology and policy decisions. A recent example was during the severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) pandemic when blood services monitored the seroprevalence in blood donors. Based on this experience, blood services have the opportunity to expand their role
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Dose‐dependent inactivation of Plasmodium falciparum in red blood cell concentrates by treatment with short‐wavelength ultraviolet light Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Swantje Fischer, Susann Zilkenat, Mona Rosse, Torsten J. Schulze, Axel Seltsam, Wiebke Handke, Bernd Lepenies, Ute Gravemann
Background and ObjectivesPlasmodium species are naturally transmitted by Anopheles mosquitos. The parasite infects red blood cells (RBCs) and can be transfused with blood products. In non‐endemic areas, the main risk of infection arises from travellers coming back and people immigrating from malaria‐endemic regions. Endemic countries face a permanent risk of infection from transfusion‐transmitted malaria
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Higher rates of laboratory‐confirmed cases of syphilis in Western Canadian blood donors compared with Eastern Canadian blood donors following a period of societal re‐opening Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Steven J. Drews, Carmen Charlton, Vanessa Tran, Hong Yuan Zhou, Gordon Hawes, Ilona Resz, Sheila F. O'Brien
Background and ObjectivesThere is a growing infectious syphilis outbreak in Western Canada. Although blood donors are screened for syphilis risks, some blood donors will still be confirmed test‐positive for syphilis. This study compares the characteristics of confirmed test‐positive syphilis donations in both Western Canada and Eastern Canada, November 2022–August 2023.Materials and MethodsDonors were
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Managing the risk of transfusion‐transmitted malaria from Australian blood donations: Recommendation of a new screening strategy Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Katia Schenberg, Veronica C. Hoad, Robert Harley, Peter Bentley
Background and ObjectivesTo reduce the risk of transfusion‐transmitted malaria (TTM) from transfusible components, Australia tests for malaria antibodies in both travellers returning from and former residents of malaria‐endemic areas. The testing is performed a minimum of 120 days after last potential exposure. TTM is an extremely rare event and managing the risk adds considerable complexity. The objectives
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Routine maternal ABO/Rhesus D blood typing can alert of massive foetomaternal haemorrhage Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Lilach Bonstein, Hussaien Khaldi, Eldad J. Dann, Zeev Weiner, Chen Ben David, Ido Solt
Background and ObjectivesSpontaneous massive foetomaternal haemorrhage (SM‐FMH) is a rare yet critical condition that poses substantial risk to foetal health and survival. Existing data indicate that many cases may be undiagnosed. The current study aimed to investigate and validate the utility of identifying mixed field red blood cell (RBC) agglutination during maternal blood typing as a diagnostic
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Re‐evaluating treatment thresholds in patient blood management: Female patients experience more perioperative anaemia and higher transfusion rates in major elective surgery Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Sumedha Arya, Alanna Howell, Lee Vernich, Yulia Lin, Katerina Pavenski, John Freedman
Background and ObjectivesBy optimizing erythropoiesis, patient blood management (PBM) programmes can reduce transfusions, lower mortality and provide cost‐effective care. While definitions of anaemia have historically varied by sex, for the purposes of PBM, anaemia is defined as a haemoglobin <130 g/L. Our objective was to describe whether perioperative anaemia and transfusion rates in the PBM setting
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Optimal malarial screening strategy in Australian blood donors: A cost‐effectiveness analysis Vox Sang. (IF 1.8) Pub Date : 2024-07-25 Qinglu Cheng, Veronica C. Hoad, Peter Bentley, Robert Harley, Katia Schenberg, Virginia Wiseman
Background and ObjectivesThe risk of transfusion‐transmitted malaria (TTM) infections is extremely low in Australia, and the cost‐effectiveness of the current screening strategy has not been assessed. This study aims to conduct a cost‐effectiveness analysis of different malaria screening strategies in blood donors as part of the risk‐based decision‐making framework.Materials and MethodsA decision tree
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Molecular Biological Aspects of Inhibitor Development Vox Sang. (IF 1.8) Pub Date : 2024-07-13 E.G.D. Tuddenham
Mutation genotype studies have led to a number of interesting observations about the role of the different types of mutations in inhibitor development. Searchable information on mutations, phenotype data, models, etc., are available on the internet at http://europium.mrc.rpms.ac.uk. A relatively high incidence of inhibitors occurs in patients with deletion mutations. Stop mutations are also associated
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Degradation Products of Factor VIII Which Can Lead to Increased Immunogenicity Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Djuro Josić, Andrea Buchacher, Christoph Kannicht, Yow‐Pin Lim, Klemens Löster, Katharina Pock, Stephen Robinson, Horst Schwinn, Monika Stadler
The biochemical and immunochemical aspects of the development of inhibitors with a plasma‐derived, double‐virus inactivated factor VIII (FVIII) concentrate (marketed as Octavi SDPlus in Germany and Bisinact in Belgium) are described. A total of 12 cases of inhibitor formation (predominantly type II) were reported in Germany, 8 in Belgium but none in Portugal. Initially, the only difference between
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Factor IX Antibody and Immune Tolerance Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Indira Warrier
Prevalence of FIX inhibitor is ten times lower than factor VIII inhibitor. FIX inhibitor patients pose major challenges for treatment because of the simultaneous occurrence of severe allergy to FIX at the time of inhibitor development. Immune tolerance induction in haemophilia B inhibitor patients with allergy to FIX is complicated due to the development of nephrotic syndrome. Moreover, response to
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Measuring of Factor VIII Inhibitors according to the Bethesda Method in Patients with Product‐Related Inhibitors in Comparison to Non‐Product Related Inhibitors Vox Sang. (IF 1.8) Pub Date : 2024-07-13 U. Budde, E. Drewke
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Inhibitor Development in Prospective Clinical Trials with Recombinant Factor VIII Preparations in Previously Untreated Patients Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Jeanne M. Lusher
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Induction of Immune Tolerance in Haemophilia A Inhibitor Patients by the ‘Bonn Protocol‘: Predictive Parameter for Therapy Duration and Outcome Vox Sang. (IF 1.8) Pub Date : 2024-07-13 J. Oldenburg, R. Schwaab, H.H. Brackmann
The treatment of inhibitors is one of the most challenging fields in haemophilia care. The present study reports the results of 60 haemophilia A inhibitor patients treated according to the ‘Bonn Protocol’ and evaluates predictors for the duration and outcome of therapy. Successful immune tolerance could be achieved in 52 patients (86.7%) while the therapy failed in eight patients (13.3%). The immune
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Epitope Specificity and Inactivation Mechanisms of Factor VIII Inhibitor Antibodies Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Dorothea Scandella
The domain specificity of anti‐factor VIII (FVIII) inhibitor antibodies was determined in assays using FVIII domains generated by thrombin cleavage or expressed as recombinant polypeptides to neutralise the inhibitor. The results revealed the existence of three major types of inhibitors, and various combinations of these antibodies were found in haemophilic and autoantibody patients. Anti‐A2 domain
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Analysis of the North American Immune Tolerance Registry (NAITR) 1993–1997: Current Practice Implications Vox Sang. (IF 1.8) Pub Date : 2024-07-13 D.M. DiMichele, B.L. Kroner, ISTH Factor VIII/IX Subcommittee Members
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International Immune Tolerance Registry, 1997 Update Vox Sang. (IF 1.8) Pub Date : 2024-07-13 G. Mariani, B. Kroner
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Comparison of the International Immune Tolerance Registry and the North American Immune Tolerance Registry Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Barbara L. Kroner
Two immune tolerance registries – the International Immune Tolerance Study Group (ITSG) and North American Immune Tolerance Study (NAITS) – are compared and findings from combined data reported. The registries differed with respect to data collection tools, location, host and environmental factors, start date distribution and treatment products. The success and failure rates were similar in the two
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Immune Tolerance Protocols Using Low‐Dose Factor VIII: A Review of the Literature Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Y. Sultan
Low‐dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low‐dose protocols appeared in 1981, described small numbers of patients and moderate success. It was proposed that such protocols might modify
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Extracorporeal Immunoadsorption for the Treatment of Haemophilia Patients with Inhibitors to Factor VIII or IX Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Paul Knöbl, Kurt Derfler
Background and Objectives: This article reviews the relevance of immunoadsorption in the treatment of haemophilic patients with inhibitors. Materials and Methods: Immunosorba (sepharose‐bound staphylococcal protein A) and Ig‐Therasorb (sepharose‐bound polycional sheep antibodies to human immunoglobulin) columns are suitable for the clinical use of immunoadsorption. They allow the processing of large
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Factor Xa and Prothrombin: Mechanism of Action of FEIBA Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Peter L. Turecek, Katalin Varadi, Herbert Gritsch, Wilfried Auer, Ludwig Pichler, Gerald Eder, Hans Peter Schwarz
A complex consisting of activated factor X (FX) (enzyme) and prothrombin (substrate), both highly purified from human plasma and virus inactivated, was formulated, characterised biochemically as well as in animal studies, and given the name Partial Prothrombinase (PPT). In vitro, PPT shortened the clotting time of a high‐titre human factor VIII (FVIII) inhibitor plasma in a manner similar to that of
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The German National Immune Tolerance Registry, 1997 Update Vox Sang. (IF 1.8) Pub Date : 2024-07-13 H. Lenk, Study Group of German Haemophilia Centres
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Epidemiology of Inhibitor Development in Haemophilia A Patients Treated with Virus‐Inactivated Plasma‐Derived Clotting Factor Concentrates Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Wolfhart Kreuz, Carmen Escuriola‐Ettingshausen, Inmaculada Martinez‐Saguer, Monika Kaiml, Bernhard Kornhuber
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Treatment of Acute Bleeding Episodes with rFVIIa Vox Sang. (IF 1.8) Pub Date : 2024-07-13 J. Ingerslev, O. Sneppen, I. Hvid, U. Fredberg, H.L. Kristensen, S. Sindet‐Petersen
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Anti‐ldiotypic Antibodies: From Regulation to Therapy of Factor VIII Inhibitors Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Jean‐Marie R. Saint‐Remy, Marc G. Jacquemin, Jean Guy Gilles
Evidence has recently accumulated showing that antiidiotype antibodies specific to anti‐FVIII antibodies are present in the plasma of healthy individuals and of haemophilia A patients with or without inhibitors, where they can neutralise the FVIII inhibitory activity. Additionally, patients successfully desensitised towards FVIII have an increased production of anti‐idiotypic antibodies with no significant
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Human Factor VIII for Bleeding in Patients with Inhibitors Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Carol K. Kasper
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Successful Immune Tolerance Treatment with Monoclonal or Recombinant Factor VIII Concentrates in High Responding Inhibitor Patients Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Angiola Rocino, Raffaello de Biasi
Very high purity factor VIII (FVI1I) concentrates (plasma‐derived or produced by recombinant‐DNA technology) were used to achieve immune tolerance in five patients with high‐responding inhibitors to FVIII. The mean time required for inhibitor disappearance was 5 months. Four out of five patients showed normalisation of the half‐life of infused FVIII after 8–18 months of treatment with 100 IU FVIII/kg
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The Use of Agents that By‐Pass Factor VIII Inhibitors in Patients with Haemophilia Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Harold R. Roberts
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Factor VIII Inhibitor‐Tests Could Be Less Sensitive Than Supposed Vox Sang. (IF 1.8) Pub Date : 2024-07-13 M. Bartheis, M. Kraus, U. Bohn, B. Liese, M. von Depka, R. Eisert, A. Ganser
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Malmö International Brother Study (MIBS): An International Survey of Brother Pairs with Haemophilia Vox Sang. (IF 1.8) Pub Date : 2024-07-13 Jan Astermark, Erik Berntorp
Malmö International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non‐twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs
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Donor knowledge and perceptions regarding donation‐induced iron depletion and iron supplementation as a blood service policy Vox Sang. (IF 1.8) Pub Date : 2024-07-11 Jan H. M. Karregat, Franke A. Quee, Jos W. R. Twisk, Katja van den Hurk
Background and ObjectivesRegular whole blood donations are associated with an increased risk of iron deficiency. Iron supplementation is an effective strategy to prevent donation‐induced iron deficiency. However, research on donor perceptions towards such a policy is limited. Therefore, we aim to evaluate donors' knowledge on donation‐induced iron depletion and their perceptions regarding iron supplementation
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Screening, genotyping and haematological analysis of glucose‐6‐phosphate dehydrogenase deficiency in the blood donors of Wuxi City, China Vox Sang. (IF 1.8) Pub Date : 2024-07-06 Jianhuai Jin, Jian Jiang, Youshan Xu, Li Gao, Wenhui Sun, Ruixin Jiang, Jing Gao
Background and ObjectivesTo investigate the prevalence, genotype and haematological characteristics of glucose‐6‐phosphate dehydrogenase (G6PD) deficiency in the blood donor population of Wuxi area (Jiangsu Province, China) and to assess the impact of their red blood cell (RBC) units on clinical transfusion.Materials and MethodsWe conducted genotyping and large‐scale screening for G6PD enzyme activity
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Urban arbovirus exposure in blood donations from an endemic area of Brazil Vox Sang. (IF 1.8) Pub Date : 2024-07-06 Rhayany Redon de Sant'Anna, Priscila Conrado Guerra Nunes, Flavia Barreto dos Santos
Background and ObjectivesIn Brazil, urban arboviruses, such as dengue virus (DENV), Zika virus (ZIKV) and chikungunya virus (CHIKV), constitute a major public health problem, and due to their endemicity and asymptomatic cases, they pose a potential threat to blood donations. Rio de Janeiro (RJ), Brazil, has been impacted by extensive DENV epidemics over the last 30 years and, after 2015, by CHIKV and