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Unraveling devitalization: its impact on immune response and ectopic bone remodeling from autologous and allogeneic callus mimics. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-14 Leanne de Silva,Jeroen J J P van den Beucken,Antoine J W P Rosenberg,Alessia Longoni,Debby Gawlitta
Endochondral bone regeneration is a promising approach in regenerative medicine. Callus mimics (CMs) are engineered and remodeled into bone tissue upon implantation. The long-term objective is to fabricate a sustainable off-the-shelf treatment option for patients. Devitalization was introduced to facilitate storage and using allogeneic (donor) cells would further propel the off-the-shelf approach.
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Decoded cardiopoietic cell secretome linkage to heart repair biosignature. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-11 Armin Garmany,D Kent Arrell,Satsuki Yamada,Ryounghoon Jeon,Atta Behfar,Sungjo Park,Andre Terzic
Cardiopoiesis-primed human stem cells exert sustained benefit in treating heart failure despite limited retention following myocardial delivery. To assess potential paracrine contribution, the secretome of cardiopoiesis conditioned versus naïve human mesenchymal stromal cells was decoded by directed proteomics augmented with machine learning and systems interrogation. Cardiopoiesis doubled cellular
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Cell-based therapy in the treatment of musculoskeletal diseases. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-03 Justin Trapana,Jonathan Weinerman,Danny Lee,Anil Sedani,David Constantinescu,Thomas M Best,Francis J Hornicek,Joshua M Hare
A limited number of tissues can spontaneously regenerate following injury, and even fewer can regenerate to a state comparable to mature, healthy adult tissue. Mesenchymal stem cells (MSCs) were first described in the 1960s-1970s by Friedenstein et al as a small population of bone marrow cells with osteogenic potential and abilities to differentiate into chondrocytes. In 1991, Arnold Caplan coined
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Impact of compression forces on different mesenchymal stem cell types regarding orthodontic indication. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-24 Chloé Radermacher,Rogerio B Craveiro,Wilhelm Jahnen-Dechent,Justus P Beier,Astrid Bülow,Michael Wolf,Sabine Neuss
The potential of stem cells, for example upper periodontal ligament stem cells from the maxilla (u-PDLSC) and from the mandible (l-PDLSC), adipose-derived mesenchymal stem cells (AD-MSC), and bone marrow-derived mesenchymal stem cells (BM-MSC), with respect to periodontal remodeling and orthodontic treatment is of great importance. In this work, we focus on the comprehensive adaptability of different
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Efficacy and safety of mesenchymal stem cell therapies for ischemic stroke: a systematic review and meta-analysis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Zhiyuan Shen,Xian Tang,Yaxin Zhang,Yicun Jia,Xin Guo,Xiaosu Guo,Junqiang Bao,Xiongwei Xie,Yuan Xing,Jun Xing,Shujuan Tian
BACKGROUND The efficacy and safety of mesenchymal stem cells (MSCs) in the treatment of ischemic stroke (IS) remains controversial. Therefore, this study aimed to evaluate the efficacy and safety of MSCs for IS. METHODS A literature search until May 23, 2023, was conducted using PubMed, EMBASE, the Cochrane Library, and the Web of Science to identify studies on stem cell therapy for IS. Interventional
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Recent progress in modeling and treating diabetes using stem cell-derived islets. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-19 Marlie M Maestas,Maggie H Bui,Jeffrey R Millman
Stem cell-derived islets (SC-islets) offer the potential to be an unlimited source of cells for disease modeling and the treatment of diabetes. SC-islets can be genetically modified, treated with chemical compounds, or differentiated from patient derived stem cells to model diabetes. These models provide insights into disease pathogenesis and vulnerabilities that may be targeted to provide treatment
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Effects of human umbilical cord mesenchymal stem cell-derived exosomes in the rat osteoarthritis models. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Huanfeng Yang,Yiqin Zhou,Bi Ying,Xuhui Dong,Qirong Qian,Shaorong Gao
Mesenchymal stem cells (MSCs) offer great potential for treatment of osteoarthritis (OA) by promoting articular cartilage regeneration via paracrine secretion of exosomes; however, the underlying mechanisms are not fully understood. This study aimed to explore the therapeutic effects of exosomes secreted by human umbilical cord-derived MSCs (hUC-MSCs) in rat models of OA and reveal the underlying mechanisms
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Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Mei-Lin Yang,Che-Yuan Hu,Ya-Che Lee,Chao-Ching Chang,Yi-Cheng Chen,Pei-Ru Lee,Bing-Hua Su,Pi-Che Chen,Ai-Li Shiau,Gia-Shing Shieh,Chao-Liang Wu,Pensee Wu
Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can be used as cellular vehicles for delivering oncolytic adenoviruses to tumor sites. Since telomerase activity is found in ~90% of human carcinomas, but
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Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Jia Song,Lingshu Wang,Liming Wang,Xinghong Guo,Qin He,Chen Cui,Huiqing Hu,Nan Zang,Mengmeng Yang,Fei Yan,Kai Liang,Chuan Wang,Fuqiang Liu,Yujing Sun,Zheng Sun,Hong Lai,Xinguo Hou,Li Chen
Dysregulation of α cells results in hyperglycemia and hyperglucagonemia in type 2 diabetes mellitus (T2DM). Mesenchymal stromal cell (MSC)-based therapy increases oxygen consumption of islets and enhances insulin secretion. However, the underlying mechanism for the protective role of MSCs in α-cell mitochondrial dysfunction remains unclear. Here, human umbilical cord MSCs (hucMSCs) were used to treat
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NLRP3 and AIM2 inflammasomes expression is modified by LPS and titanium ions increasing the release of active IL-1β in alveolar bone-derived MSCs. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Ana Belén Carrillo-Gálvez,Federico Zurita,José Antonio Guerra-Valverde,Araceli Aguilar-González,Darío Abril-García,Miguel Padial-Molina,Allinson Olaechea,Natividad Martín-Morales,Francisco Martín,Francisco O'Valle,Pablo Galindo- Moreno
Periodontitis and peri-implantitis are inflammatory diseases of infectious etiology that lead to the destruction of the supporting tissues located around teeth or implants. Although both pathologies share several characteristics, it is also known that they show important differences which could be due to the release of particles and metal ions from the implant surface. The activation of the inflammasome
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Requirement of Pdgfrα+ cells for calvarial bone repair. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Xin Xing,Zhao Li,Jiajia Xu,Austin Z Chen,Mary Archer,Yiyun Wang,Mingxin Xu,Ziyi Wang,Manyu Zhu,Qizhi Qin,Neelima Thottappillil,Myles Zhou,Aaron W James
Platelet-derived growth factor receptor α (PDGFRα) is often considered as a general marker of mesenchymal cells and fibroblasts, but also shows expression in a portion of osteoprogenitor cells. Within the skeleton, Pdgfrα+ mesenchymal cells have been identified in bone marrow and periosteum of long bones, where they play a crucial role in participating in fracture repair. A similar examination of Pdgfrα+
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Promotion of maturation of human pluripotent stem cell-derived cardiomyocytes via treatment with the peroxisome proliferator-activated receptor alpha agonist Fenofibrate. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Seul-Gi Lee,Jooeon Rhee,Jin Seok,Jin Kim,Min Woo Kim,Gyeong-Eun Song,Shinhye Park,Kyu Sik Jeong,Suemin Lee,Yun Hyeong Lee,Youngin Jeong,C-Yoon Kim,Hyung Min Chung
As research on in vitro cardiotoxicity assessment and cardiac disease modeling becomes more important, the demand for human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is increasing. However, it has been reported that differentiated hPSC-CMs are in a physiologically immature state compared to in vivo adult CMs. Since immaturity of hPSC-CMs can lead to poor drug response and loss of acquired
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Therapeutic potential of extracellular vesicles derived from human amniotic epithelial cells for perinatal cerebral and pulmonary injury. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Naveen Kumar,Hamid Reza Bidkhori,Tamara Yawno,Rebecca Lim,Ishmael Miguel Inocencio
Lung and brain injury that occurs during the perinatal period leads to lifelong disability and is often driven and/or exacerbated by inflammation. Human amniotic epithelial cells (hAEC), which demonstrate immunomodulatory, anti-fibrotic, and regenerative capabilities, are being explored as a therapeutic candidate for perinatal injury. However, limitations regarding scalable manufacturing, storage,
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Synergic effect of combined xenogeneic mesenchymal stem cells and ceftriaxone on acute septic arthritis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Pei-Hsun Sung,Tsung-Cheng Yin,John Y Chiang,Chih-Hung Chen,Chi-Ruei Huang,Mel S Lee,Hon-Kan Yip
BACKGROUND This study tested the hypothesis that combined ceftriaxone (Cef) and human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) was better than either therapy for alleviating acute septic arthritis (ASA). METHODS AND RESULTS Adult-male C57BL/6 mice were categorized into control group (Clt), group A (ASA only), group B [ASA + Cef (5 mg/kg, IM per day, at days 2 to 16 after ASA induction)]
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Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Yang Li,Yi Li,Chao Liu,Xinyi Yu,Ziqi Gan,Lusai Xiang,Jinxuan Zheng,Bowen Meng,Rongcheng Yu,Xin Chen,Xiaoxing Kou,Yang Cao,Tingting Ai
Mechanical force-mediated bone remodeling is crucial for various physiological and pathological processes involving multiple factors, including stem cells and the immune response. However, it remains unclear how stem cells respond to mechanical stimuli to modulate the immune microenvironment and subsequent bone remodeling. Here, we found that mechanical force induced increased expression of CD109 on
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EPHA2 is a novel cell surface marker of OCT4-positive undifferentiated cells during the differentiation of mouse and human pluripotent stem cells. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-16 Atsushi Intoh,Kanako Watanabe-Susaki,Taku Kato,Hibiki Kiritani,Akira Kurisaki
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) possess the intrinsic ability to differentiate into diverse cellular lineages, marking them as potent instruments in regenerative medicine. Nonetheless, the proclivity of these stem cells to generate teratomas post-transplantation presents a formidable obstacle to their therapeutic utility. In previous studies, we identified an
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Glutaminase-1 inhibition alleviates senescence of Wharton's jelly-derived mesenchymal stem cells via senolysis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Eun Joo Lee,Sun Jeong Kim,Su Yeon Jeon,Soobeen Chung,Sang Eon Park,Jae-Sung Kim,Suk-Joo Choi,Soo-Young Oh,Gyu Ha Ryu,Hong Bae Jeon,Jong Wook Chang
Replicative senescence of mesenchymal stem cells (MSCs) caused by repeated cell culture undermines their potential as a cell therapy because of the reduction in their proliferation and therapeutic potential. Glutaminase-1 (GLS1) is reported to be involved in the survival of senescent cells, and inhibition of GLS1 alleviates age-related dysfunction via senescent cell removal. In the present study, we
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Improving the future of clinical trials and translation of mesenchymal stromal cell therapies for neonatal disorders. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-09 Yun Sil Chang,Misun Yang,So Yoon Ahn,Se In Sung,Won Soon Park
Despite recent advances in neonatal intensive care medicine, neonatal disorders such as (bronchopulmonary dysplasia [BPD], intraventricular hemorrhage [IVH], and hypoxic ischemic encephalopathy [HIE]) remain major causes of death and morbidity in survivors, with few effective treatments being available. Recent preclinical studies have demonstrated the pleiotropic host injury-responsive paracrine protective
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Detection of residual pluripotent stem cells in cell therapy products utilizing droplet digital PCR: an international multisite evaluation study. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-09 Satoshi Yasuda,Kiyoko Bando,Marianne P Henry,Silvana Libertini,Takeshi Watanabe,Hiroto Bando,Connie Chen,Koki Fujimori,Kosuke Harada,Takuya Kuroda,Myriam Lemmens,Dragos Marginean,David Moss,Lucilia Pereira Mouriès,Nicole S Nicholas,Matthew J K Smart,Orie Terai,Yoji Sato
The presence of residual undifferentiated pluripotent stem cells (PSCs) in PSC-derived cell therapy products (CTPs) is a major safety issue for their clinical application, due to the potential risk of PSC-derived tumor formation. An international multidisciplinary multisite study to evaluate a droplet digital PCR (ddPCR) approach to detect residual undifferentiated PSCs in PSC-derived CTPs was conducted
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A novel long noncoding RNA AK029592 contributes to thermogenic adipocyte differentiation. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-08 Pengyu Hong,Dianri Wang,Yue Wu,Qi Zhang,Pan Liu,Jian Pan,Mei Yu,Weidong Tian
Exploration of factors originating from brown adipose tissue that govern the thermogenic adipocyte differentiation is imperative for comprehending the regulatory framework underlying brown fat biogenesis and for devising therapeutic approaches for metabolic disorders associated with obesity. Prior evidence has illuminated the pivotal role of long noncoding RNAs (lncRNAs) in orchestrating thermogenesis
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Cryopreserved apoptotic mesenchymal stromal cells retain functional efficacy in suppressing an allergic inflammation in a murine model. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-08-07 Richard T Amison,Tik S Cheung,Chiara Giacomini,Yanira Riffo-Vasquez,Antonio Galleu,Roberto Savoldelli,Ryan Hicks,Anna Kozlowska,Francesco Dazzi
Mesenchymal stromal cell (MSC) apoptosis is required for in vivo immunosuppression. However, the induction of apoptosis is heavily dependent on the recipient's immune system. In graft-versus-host disease (GvHD), patients who fail to respond to MSCs are in fact those whose immune cells are unable to induce MSC apoptosis ex vivo. The information is critical to explain why responses in clinical trials
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Three-dimensional cultured human umbilical cord mesenchymal stem cells attenuate pulmonary fibrosis by improving the balance of mitochondrial fusion and fission. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Huifang Zhai,Mengqi Jiang,Yaqin Zhao,Yujie Wang,Haitong Zhang,Yunxia Ji,Xiaodong Song,Jinjin Zhang,Changjun Lv,Minge Li
Pulmonary fibrosis is a kind of fibrotic interstitial pneumonia with poor prognosis. Aging, environmental pollution, and coronavirus disease 2019 are considered as independent risk factors for pulmonary fibrogenesis. Consequently, the morbidity and mortality striking continues to rise in recent years. However, the clinical therapeutic efficacy is very limited and unsatisfactory. So it is necessary
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A detailed survey of the murine limbus, its stem cell distribution, and its boundaries with the cornea and conjunctiva. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-30 Lamia Nureen,Joanna Biazik,Michael Carnell,Nick Di Girolamo
The narrow intersection between the cornea and conjunctiva, otherwise known as the limbus, is purported to harbor stem cells (SCs) that replenish the ocular surface epithelium throughout life. Damage to this site or depletion of its SCs can have dire consequences for eye health and vision. To date, various SC and keratin proteins have been used to identify the limbus, however, none could definitively
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Mitigation of supply chain challenges in cell therapy manufacturing: perspectives from the cord blood alliance. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Patrick Killela,Kieran Herrity,Ludwig Frontier,Roger Horton,Joanne Kurtzberg,Wouter Van't Hof
Cellular therapies rely on highly specialized supply chains that often depend on single source providers. Public cord blood banks (CBB) manufacturing the first cell therapy to be highly regulated by the FDA and related international agencies are a prime example of being subject to this phenomenon. In addition to banking unrelated donor cord blood units for transplantation, CBBs also source and characterize
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The evolution and ongoing challenge of unproven cell-based interventions. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Taylor N Brinsfield,Noah R Pinson,Aaron D Levine
Unproven cell-based interventions (CBIs) emerged early in the 2000s as a particularly problematic form of unproven therapy and remain a vexing policy problem to this day. These unproven interventions can harm patients both physically and financially and can complicate the process of developing a rigorous evidence base to support the translation of novel stem cell or other cell therapies. In this concise
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GMP-compliant iPS cell lines show widespread plasticity in a new set of differentiation workflows for cell replacement and cancer immunotherapy. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Daniel Terheyden-Keighley,Melanie Hühne,Thomas Berger,Björn Hiller,Soraia Martins,Anna Gamerschlag,Davood Sabour,Andrea Meffert,Andreas Kislat,Carsten Slotta,Francois Hafezi,Jens Lichte,Smita Sudheer,Karen Tessmer,Katherina Psathaki,Marius Ader,Gesine Kogler,Boris Greber
Cell therapeutic applications based on induced pluripotent stem cells (iPSCs) appear highly promising and challenging at the same time. Good manufacturing practice (GMP) regulations impose necessary yet demanding requirements for quality and consistency when manufacturing iPSCs and their differentiated progeny. Given the scarcity of accessible GMP iPSC lines, we have established a corresponding production
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MISEV2023 provides an updated and key reference for researchers studying the basic biology and applications of extracellular vesicles. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Dinesh Upadhya,Ashok K Shetty
The recently published "Minimal information for studies of extracellular vesicles - 2023 (MISEV2023)" in the Journal of Extracellular Vesicles has provided practical solutions to the numerous challenges extracellular vesicles (EVs) researchers face. These guidelines are imperative for novice and experienced researchers and promote unity within the EV community. It is strongly recommended that laboratories
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Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Minseong Kim,Hojun Choi,Deok-Jin Jang,Hye-Jung Kim,Yujin Sub,Heon Yung Gee,Chulhee Choi
Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such as biocompatibility, immune tolerability, and target specificity. Various engineering strategies have been implemented to harness these innate qualities, with a focus on enhancing the pharmacokinetic and pharmacodynamic properties of exosomes via payload loading and
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Umbilical cord blood-derived therapy for preterm lung injury: a systematic review and meta-analysis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Elisha Purcell,Jainam Shah,Cameron Powell,Timothy Nguyen,Lindsay Zhou,Courtney A McDonald,Beth J Allison,Atul Malhotra
INTRODUCTION Lung injuries, such as bronchopulmonary dysplasia (BPD), remain a major complication of preterm birth, with limited therapeutic options. One potential emerging therapy is umbilical cord blood (UCB)-derived therapy. OBJECTIVES To systematically assess the safety and efficacy of UCB-derived therapy for preterm lung injury in preclinical and clinical studies. METHODS A systematic search of
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Bone mesenchymal stem cells improve cholestatic liver fibrosis by targeting ULK1 to regulate autophagy through PI3K/AKT/mTOR pathway. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Tingjuan Huang,Chunhong Zhang,Ziyi Shang,Qizhi Shuai,Lina Nie,Junjie Ren,Shulin Hou,Jun Xie
Cholestatic liver disease (CLD) is a severe disease, which can progress to liver cirrhosis, even liver cancer. Hepatic stellate cells (HSCs) activation plays a crucial role in CLD development. Bone mesenchymal stem cells (BMSCs) treatment was demonstrated to be beneficial in liver diseases. However, the therapeutic effect and mechanism of BMSCs on CLD are poorly known. In the present study, we investigated
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Endothelial progenitor cells for diabetic cardiac and kidney disease. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Matthew J Raleigh,Sachin V Pasricha,Aaron Nauth,Michael R Ward,Kim A Connelly
The management of diabetes mellitus and its resultant end organ dysfunction represents a major challenge to global health-care systems. Diabetic cardiac and kidney disease commonly co-occur and are significant contributors to the morbidity and mortality of patients with diabetes, carrying a poor prognosis. The tight link of these parallel end organ manifestations suggests a deeper common underlying
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MEK/ERK signaling drives the transdifferentiation of supporting cells into functional hair cells by modulating the Notch pathway. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Jiaoyao Ma,Mingyu Xia,Jin Guo,Wen Li,Shan Sun,Bing Chen
Loss of cochlear hair cells (HCs) leads to permanent hearing loss in mammals, and regenerative medicine is regarded as an ideal strategy for hearing recovery. Limited genetic and pharmaceutical approaches for HC regeneration have been established, and the existing strategies cannot achieve recovery of auditory function. A promising target to promote HC regeneration is MEK/ERK signaling because dynamic
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Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Ricardo de Souza Tesch,Esther Rieko Takamori,Karla Menezes,Rosana Bizon Vieira Carias,Carmen Lucia Kuniyoshi Rebelatto,Alexandra Cristina Senegaglia,Debora Regina Daga,Leticia Fracaro,Anny Waloski Robert,Carlos Bruno Reis Pinheiro,Marcelo de Freitas Aguiar,Pablo Javier Blanco,Eduardo Guerreiro Zilves,Paulo Roberto Slud Brofman,Radovan Borojevic
Condylar resorption is an aggressive and disability form of temporomandibular joint (TMJ) degenerative disease, usually non-respondent to conservative or minimally invasive therapies and often leading to surgical intervention and prostheses implantation. This condition is also one of the most dreaded postoperative complications of orthognathic surgery, with severe cartilage erosion and loss of subchondral
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Transcriptomic analysis reveals the anti-cancer effect of gestational mesenchymal stem cell secretome. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-07-15 Salvatore Vaiasicca,Gianmarco Melone,David W James,Marcos Quintela,Jing Xiao,Seydou Yao,Richard H Finnell,Robert S Conlan,Lewis W Francis,Bruna Corradetti
The environment created during embryogenesis contributes to reducing aberrations that drive structural malformations and tumorigenesis. In this study, we investigate the anti-cancer effect of mesenchymal stem cells (MSCs) derived from 2 different gestational tissues, the amniotic fluid (AF) and the chorionic villi (CV), with emphasis on their secretome. Transcriptomic analysis was performed on patient-derived
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Enhanced radiation sensitivity, decreased DNA damage repair, and differentiation defects in airway stem cells derived from patients with chronic obstructive pulmonary disease. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Lorena Giuranno,Jolanda A F Piepers,Evelien Korsten,Reitske Borman,Gerarda van de Kamp,Dirk De Ruysscher,Jeroen Essers,Marc A Vooijs
Radiation therapy (RT) is a common treatment for lung cancer. Still, it can lead to irreversible loss of pulmonary function and a significant reduction in quality of life for one-third of patients. Preexisting comorbidities, such as chronic obstructive pulmonary disease (COPD), are frequent in patients with lung cancer and further increase the risk of complications. Because lung stem cells are crucial
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Current cell therapies for systemic lupus erythematosus. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-09-10 Lan T M Dao,Thu Thuy Vu,Quyen Thi Nguyen,Van T Hoang,Thanh Liem Nguyen
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which multiple organs are damaged by the immune system. Although standard treatment options such as hydroxychloroquine (HCQ), glucocorticoids (GCs), and other immunosuppressive or immune-modulating agents can help to manage symptoms, they do not offer a cure. Hence, there is an urgent need for the development of novel drugs and therapies
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Human Amniotic Epithelial Cell Transplantation is Safe and Well Tolerated in Patients with Compensated Cirrhosis: A First-in-Human Trial. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Rebecca Lim,Alexander Hodge,Sherryne Warner,Gregory T Moore,Jeanne Correia,Mirja Krause,Hannah McDonald,Siow T Chan,Mihiri Goonetilleke,Stuart M Lyon,William Sievert
Placenta-derived human amniotic epithelial cells (hAEC) exhibit anti-inflammatory and anti-fibrotic effects in cirrhosis models. We conducted a first-in-human phase I clinical trial to assess the safety and tolerability of hAEC in adults with compensated cirrhosis. We examined increasing and repeated doses of hAEC in 9 patients in 3 cohorts. Cohort 1 patients received 0.5 × 106/kg hAEC in one IV infusion
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Human In Vitro Models of Neuroenergetics and Neurometabolic Disturbances: Current Advances and Clinical Perspectives. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Julia Rogal,Laura Nicoleti Zamproni,Polyxeni Nikolakopoulou,Sofia Ygberg,Anna Wedell,Anna Wredenberg,Anna Herland
Neurological conditions conquer the world; they are the leading cause of disability and the second leading cause of death worldwide, and they appear all around the world in every age group, gender, nationality, and socioeconomic class. Despite the growing evidence of an immense impact of perturbations in neuroenergetics on overall brain function, only little is known about the underlying mechanisms
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Long-Term Outcome Following Treatment With Allogeneic Mesenchymal Stem/Stromal Cells for Radiation-Induced Hyposalivation and Xerostomia. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Kathrine Kronberg Jakobsen,Charlotte Duch Lynggaard,Natasja Paaske,Amanda-Louise Fenger Carlander,Jens Kastrup,Anne Werner Hauge,Robin Christensen,Christian Grønhøj,Christian von Buchwald
BACKGROUND Adipose-derived mesenchymal stem/stromal cells (ASCs) are proposed as a new xerostomia treatment. The study evaluated the long-term safety and effectiveness of allogeneic ASCs in radiation-induced xerostomia among patients with previous oropharyngeal cancer. METHODS This study constitutes 3-year follow-up on the original 10 patients who received allogeneic ASCs injections to the submandibular
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Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Shinya Minatoguchi,Yasuyuki Fujita,Kuniyasu Niizuma,Teiji Tominaga,Toru Yamashita,Koji Abe,Mari Dezawa
The strength of stem cell therapy is the regeneration of tissues by synergistic pleiotropic effects. Among many stem cell types, mesenchymal stem cells (MSCs) that are comprised of heterogenous population are widely used for clinical applications with the expectation of pleiotropic bystander effects. Muse cells are pluripotent-like/macrophage-like stem cells distributed in the bone marrow, peripheral
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Influence of Substrate Stiffness on iPSC-Derived Retinal Pigmented Epithelial Cells. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Rion J Wendland,Budd A Tucker,Kristan S Worthington
Retinal degenerative diseases are a major cause of blindness involving the dysfunction of photoreceptors, retinal pigmented epithelium (RPE), or both. A promising treatment approach involves replacing these cells via surgical transplantation, and previous work has shown that cell delivery scaffolds are vital to ensure sufficient cell survival. Thus, identifying scaffold properties that are conducive
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Study on the Extrapolability of Current Tumorgenicity Test With Mice by Comparing the Syngeneic or Allogeneic Mouse Transplantation Model. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Takashi Tamura,Tsuyoshi Tahara,Michiko Inoue,Ryota Nanjo,Hirotaka Onoe,Takako Yamamoto,Shin Kawamata
The extrapolability of the current tumorigenicity test performed by transplanting human cell product into immunodeficient (NOG) mice was investigated. For this purpose, the susceptibility to form teratomas of NOG mice was assessed by transplanting undifferentiated human-induced pluripotent stem cells (hiPSCs) as positive control cells via the liver, striatum, or tail vein and evaluating the TPD50 value
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Precision Delivery of Human Bone Marrow-Derived Mesenchymal Stem Cells Into the Pancreas Via Intra-arterial Injection Prevents the Onset of Diabetes. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Rosita Primavera,Shobha Regmi,Reza Yarani,Steven Levitte,Jing Wang,Abantika Ganguly,Shashank Chetty,Michele Guindani,Camillo Ricordi,Everett Meyer,Avnesh S Thakor
Mesenchymal stem cells (MSCs) are a promising therapy to potentially treat diabetes given their potent anti-inflammatory and immune-modulatory properties. While these regenerative cells have shown considerable promise in cell culture, their clinical translation has been challenging. In part, this can be attributed to these cells not reaching the pancreas to exert their regenerative effects following
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Longitudinal Magnetic Resonance Imaging Tracking of Transplanted Neural Progenitor Cells in the Spinal Cord Utilizing the Bright-Ferritin Mechanism. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-06-14 Zixiang Luo,Keyu Zhuang,Seong Jun Kim,Kyle D W Vollett,Zijian Lou,Jian Wang,Hai-Ying Mary Cheng,Mohamad Khazaei,Michael G Fehlings,Hai-Ling Margaret Cheng
Human neural progenitor cells (hNPCs) hold promise for treating spinal cord injury. Studies to date have focused on improving their regenerative potential and therapeutic effect. Equally important is ensuring successful delivery and engraftment of hNPCs at the injury site. Unfortunately, no current imaging solution for cell tracking is compatible with long-term monitoring in vivo. The objective of
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Impact of FDA's HCT/P ZIKV Recommendations on Cord Blood Unit Eligibility and Utilization in a Large Public Cord Blood Bank. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Dana S Guggenheim,Joanne Kurtzberg,Beth H Shaz
BACKGROUND Cord blood units (CBUs) that are ineligible for licensure due to incomplete compliance with FDA recommendations may be used for hematopoietic stem cell transplantation under urgent medical need and an Investigational Drug Application. The largest reason for CBU donor ineligibility is Zika virus (ZIKV) risk. The study's objective was to analyze the impact of current FDA recommendations for
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The Treatment of Refractory Vitiligo With Autologous Cultured Epithelium Grafting: A Real-World Retrospective Cohort Study. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Jian Li,Xuanhao Zeng,Shujun Chen,Luyan Tang,Qi Zhang,Minzi Lv,Weiling Lian,Jinqi Wang,Haozhen Lv,Yating Liu,Jiayi Shen,Taro Uyama,Fuyue Wu,Jinfeng Wu,Jinhua Xu
BACKGROUND Surgical intervention is the main therapy for refractory vitiligo. We developed a modified autologous cultured epithelial grafting (ACEG) technique for vitiligo treatment. Between January 2015 and June 2019, a total of 726 patients with vitiligo underwent ACEG in China, with patient characteristics and clinical factors being meticulously documented. Using a generalized linear mixed model
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Stem Cell Derived Extracellular Vesicle Therapy for Multiple Sclerosis, A Systematic Review and Meta-Analysis of Preclinical Studies. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Mehri Barabadi,Madison C B Paton,Naveen Kumar,Rebecca Lim,Natalie L Payne
Stem cell therapy holds promise for multiple sclerosis (MS), with efficacy of different stem cell types reported across a range of preclinical MS animal models. While stem cell therapy has been approved for a small number of diseases in humans, extracellular vesicles (EVs) may provide an efficacious, cost-effective, and safer alternative to stem cell therapy. To this end, we conducted a systematic
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Advances in 3D Bioprinted Cardiac Tissue Using Stem Cell-Derived Cardiomyocytes. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Jacqueline M Bliley,Maria A Stang,Anne Behre,Adam W Feinberg
The ultimate goal of cardiac tissue engineering is to generate new muscle to repair or replace the damaged heart. This requires advances in stem cell technologies to differentiate billions of cardiomyocytes, together with advanced biofabrication approaches such as 3D bioprinting to achieve the requisite structure and contractile function. In this concise review, we cover recent progress in 3D bioprinting
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The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Sen Ren,Chengcheng Li,Hewei Xiong,Qian Wu,Xiaohui Wu,Zhongwei Xiong,Lixing Dong,Bing Shu,Wei Wei,Chao Ma,Xiang Li,Jincao Chen
Adipose stem cell (ASC)-based therapies provide an encouraging option for tissue repair and regeneration. However, the function of these cells declines with aging, which limits their clinical transformation. Recent studies have outlined the involvement of long non-coding RNAs in stem cell aging. Here, we reanalyzed our published RNA sequencing (RNA-seq) data profiling differences between ASCs from
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Manufacturing Parameters for the Creation of Clinical-Grade Human-Induced Pluripotent Stem Cell Lines From Umbilical Cord Mesenchymal Stromal Cells. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Liziane Raquel Beckenkamp,Camila Gomes da Silva,Mônica Luiza Immig Von Hohendorff,Karolyn Sassi Ogliari
Induced pluripotent stem cells (iPSCs) are reprogrammed cells with a remarkable capacity for unlimited expansion and differentiation into various cell types. Companies worldwide are actively engaged in developing clinical-grade iPSC lines to address the needs of regenerative medicine, immunotherapies, and precision medicine. However, ensuring the safety and quality of iPSCs is essential, with adherence
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Curcumin Improves Functional Recovery of Ruptured Tendon by Promoting Tenogenesis via PI3K/Akt Signaling. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Zhan Zhang,Yiqun Zhang,Han Wang,Baolong Li,Rangjuan Cao,Yan Li,Shusen Cui,Weizhong Zhang
OBJECTIVE In our previous study, we found that local release of curcumin from nanomicelles prevents peritendinous adhesion during Achilles tendon healing. The aim of this study is to further investigate the signaling integrated by curcumin to direct the tenogenetic program of tendon stem cells contributing to tendon healing. METHODS A surgical model of tendon rupture and repair (TRR) was established
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Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-05-14 Jessica L Mueller,Rhian Stavely,Richard A Guyer,Ádám Soos,Sukhada Bhave,Chris Han,Ryo Hotta,Nandor Nagy,Allan M Goldstein
Regenerative cell therapy to replenish the missing neurons and glia in the aganglionic segment of Hirschsprung disease represents a promising treatment option. However, the success of cell therapies for this condition are hindered by poor migration of the transplanted cells. This limitation is in part due to a markedly less permissive extracellular environment in the postnatal gut than that of the
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Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Valeriia Klymenko,Orlando G González Martínez,Marco A Zarbin
Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of photoreceptors as treatment for these conditions are underway. In this review, we summarize recent progress in the field of photoreceptor transplantation, including some pertinent results regarding photoreceptor manufacture, photoreceptor
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Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy for Retinal Disease. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Valeriia Klymenko,Orlando G González Martínez,Marco Zarbin
Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of retinal pigment epithelial cells and/or photoreceptors as a treatment for these conditions are underway. In this review, we summarize recent progress in the field of retinal pigment epithelium transplantation, including some pertinent
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Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Christine Hum,Usama Tahir,Shirley H J Mei,Josee Champagne,Dean A Fergusson,Manoj Lalu,Duncan J Stewart,Keith Walley,John Marshall,Claudia C Dos Santos,Brent W Winston,Asher A Mendelson,Chintan Dave,Lauralyn McIntyre
BACKGROUND In preclinical studies, mesenchymal stromal cells (MSCs), including umbilical cord-derived MSCs (UC-MSCs), demonstrate the ability to modulate numerous pathophysiological processes related to sepsis; however, a systematic synthesis of the literature is needed to assess the efficacy of UC-MSCs for treating sepsis. OBJECTIVE To examine the effects of UC-MSCs on overall mortality (primary outcome)
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Conditioned Medium From Stem Cells of Human Exfoliated Deciduous Teeth Alleviates Mouse Osteoarthritis by Inducing sFRP1-Expressing M2 Macrophages. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Linze Xia,Fumiya Kano,Noboru Hashimoto,Yao Liu,Tsendsuren Khurel-Ochir,Naoko Ogasawara,Cheng Ding,Yang Xu,Hideharu Hibi,Tomonori Iwasaki,Eiji Tanaka,Akihito Yamamoto
Intravenous administration of conditioned medium from stem cells of human exfoliated deciduous teeth (SHED-CM) regenerates mechanically injured osteochondral tissues in mouse temporomandibular joint osteoarthritis (TMJOA). However, the underlying therapeutic mechanisms remain unclear. Here, we showed that SHED-CM alleviated injured TMJ by inducing anti-inflammatory M2 macrophages in the synovium. Depletion
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Mesenchymal Stem Cells-Derived Exosomes Alleviate Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Peipei Liu,Shengnan Yang,Xuecheng Shao,Chen Li,Zai Wang,Huaping Dai,Chen Wang
Acute lung injury (ALI) is an important pathological process of acute respiratory distress syndrome, yet there are limited therapies for its treatment. Mesenchymal stem cells-derived exosomes (MSCs-Exo) have been shown to be effective in suppressing inflammation. However, the effects of MSCs-Exo on ALI and the underlying mechanisms have not been well elucidated. Our data showed that MSCs-Exo, but not
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Optimal Therapeutic Strategy of Bone Marrow-Originated Autologous Mesenchymal Stromal/Stem Cells for ALS. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Seung Hyun Kim,Ki-Wook Oh,Min-Young Noh,Min-Soo Kwon
Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive neurodegenerative changes in motor neural networks. Given the system complexity, including anatomically distributed sites of degeneration from the motor cortex to the spinal cord and chronic pro-inflammatory conditions, a cell-based therapeutic strategy could be an alternative approach to treating ALS. Lessons from previous
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Direct Reprogramming of Fibroblasts to Osteoblasts: Techniques and Methodologies. Stem Cells Transl. Med. (IF 5.4) Pub Date : 2024-04-15 Asghar Fallah,Alexander Beke,Connor Oborn,Carrie-Lynn Soltys,Peter Kannu
Direct reprogramming (DR) is an emerging technique that can be applied to convert fibroblasts into osteoblast-like cells, promoting bone formation and regeneration. We review the current methodology of DR in relation to the creation of induced osteoblasts, including a comparison of transcription factor-mediated reprogramming and nontranscription factor-mediated reprogramming. We review the selection