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European Nephrologists' Attitudes Towards the Application of Artificial Intelligence in Clinical Practice: A Comprehensive Survey. Blood Purif. (IF 3.0) Pub Date : 2023-11-24 Matteo Savoia,Giovanni Tripepi,Berit Goethel-Paal,Maria Eva Baró Salvador,Pedro Ponce,Daniela Voiculescu,Martin Pachmann,Tomas Jirka,Serkan Kubilay Koc,Wojciech Marcinkowski,Mario Cioffi,Luca Neri,Len Usvyat,Jeffrey L Hymes,Franklin W Maddux,Carmine Zoccali,Stefano Stuard
INTRODUCTION The rapid advancement of artificial intelligence and big data analytics, including descriptive, diagnostic, predictive, and prescriptive analytics, has the potential to revolutionize many areas of medicine, including nephrology and dialysis. Artificial intelligence and big data analytics can be used to analyse large amounts of patient medical records, including laboratory results and imaging
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Sampling from extracorporeal circuit: a step forward for dose monitoring in CRRT. Blood Purif. (IF 3.0) Pub Date : 2023-11-22 Maria Cristina Ruffa,Vittorio Bocciero,Sergio Fabbri,Francesca Nencini,Alessandra Fanelli,Stefano Romagnoli,Zaccaria Ricci,Valentina Cauda,Gianluca Villa
INTRODUCTION Continuous renal replacement therapies (CRRT) require constant monitoring and periodic treatment readjustments, being applied to highly complex patients, with rapidly changing clinical needs. To promote precision medicine in the field of renal replacement therapy and encourage dynamic prescription, the Acute Dialysis Quality Initiative (ADQI) recommends periodically measuring the solutes
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NGAL in PD-related peritonitis: correlation with WBC over time and a possible role as outcome predictor. Blood Purif. (IF 3.0) Pub Date : 2023-11-22 Grazia Maria Virzi,Maria Mattiotti,Sabrina Milan Manani,Maddalena Gnappi,Ilaria Tantillo,Valentina Corradi,Massimo De Cal,Anna Giuliani,Mariarosa Carta,Davide Giavarina,Claudio Ronco,Monica Zanella
Introduction The present study aimed to monitor pNGAL during peritonitis episodes, and to enhance its diagnostic value by evaluating pNGAL at scheduled times in parallel with White Blood Cells count. In addition, we investigated possible correlations between pNGAL and the etiology of peritonitis evaluating it as a possible marker of clinical outcome. Methods 22 patients with PD-related peritonitis
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Early Net Ultrafiltration during Continuous Renal Replacement Therapy: Impact of Admission Diagnosis and Association with Mortality. Blood Purif. (IF 3.0) Pub Date : 2023-11-22 Benjamin Sansom,Andrew Udy,Jeffrey Presneill,Rinaldo Bellomo
INTRODUCTION Continuous Renal Replacement Therapy (CRRT) is common in the Intensive Care Unit (ICU) but a high Net ultrafiltration rate (UFNET) calculated with daily data may increase mortality. We aimed to study early UFNET practice using minute-by-minute CRRT machine recordings and to assess its association with admission diagnosis and mortality. METHODS We studied CRRT treatments in three adult
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Effectiveness of Multidisciplinary Post-Acute Kidney Injury Clinic on Awareness and Knowledge in Acute Kidney Injury Survivors. Blood Purif. (IF 3.0) Pub Date : 2023-11-21 Peerapat Thanapongsatorn,Massupa Krisem,Kanyarat Kaewnan,Tidarat Bumrungpet,Nattachai Srisawat
INTRODUCTION Acute kidney injury (AKI) awareness and knowledge among survivors is poor, leading to suboptimal self-management and follow-up care. The purpose of the study was to evaluate the impact of a multidisciplinary post-AKI clinic on AKI awareness and knowledge among survivors. METHODS We conducted a quasi-experimental study among stage II-III AKI survivors who were followed in the multidisciplinary
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Association of Lung Ultrasound B-lines with Left Ventricular Diastolic Function in Clinically Euvolemic Hemodialysis Patients. Blood Purif. (IF 3.0) Pub Date : 2023-11-21 Fengqin Li,Miao Ding,Yanzhe Wang,Qijie Chen,Yue Wu,Chuchu Zeng,Nan Zhang,Dingyu Zhu,Xiaoxia Wang
INTRODUCTION Left ventricular diastolic dysfunction (LVDD) frequently occurs in haemodialysis patients and is associated with adverse outcomes. Lung ultrasound (LUS) has been recently proposed for the quantification of extravascular lung water (ELW) through assessment of B-lines. LUS findings and their relationship with LVDD in clinically euvolemic haemodialysis patients were investigated in this study
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Is it time to give peritoneal dialysis its due place in managing acute kidney injury: Lessons learnt from COVID-19 pandemic. Blood Purif. (IF 3.0) Pub Date : 2023-11-17 Muhammad M Javaid,Adel Ekladious,Behram A Khan
Despite comparable outcomes with the extracorporeal dialysis modalities, peritoneal dialysis (PD) is seldom considered a viable option for managing acute kidney injury (AKI) in developed and resource-rich countries, where continuous renal replacement therapies (CRRT) are the mainstay of treating AKI. PD has fewer infrastructure requirements and has been shown to save lives during conflicts, natural
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Characteristics and prognostic factors of SARS-CoV-2 Omicron variant infection in hemodialysis patients: a single-center study in China. Blood Purif. (IF 3.0) Pub Date : 2023-11-16 Fan Zhang,Guoli Li,Jie Yu,Yiyu Shen,Yiya Yang,Shuangshuang Fu,Kanghan Liu,Yumei Liang,Xun Luo,Yinyin Chen
INTRODUCTION This study aimed to evaluate the characteristics and prognostic factors for coronavirus disease 2019 (COVID-19) patients on maintenance hemodialysis (HD). METHODS All admitted HD patients who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) from December 1, 2022 to January 31, 2023 were included. Patients with pneumonia were further classified into the mild
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Factors associated with dialysis initiation in patients with predialysis arteriovenous fistula. Blood Purif. (IF 3.0) Pub Date : 2023-11-15 Wanhong Lu,Xiangyun Dang,Chao Liu,Zhigang Wang,Jing Lv,Shifeng Yang,Huixian Li
INTRODUCTION A large proportion of patients initiated hemodialysis with a central vein catheter rather than a permanent vascular access which was recommended by guidelines. One major barrier was the paucity of evidence regarding the optimal timing of vascular access creation in predialysis patients. METHODS Our study prospectively enrolled 300 patients undergoing predialysis arteriovenous fistula (AVF)
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Successful Liberation from Acute Kidney Replacement Therapy in Critically Ill Patients: A Prospective Cohort Study. Blood Purif. (IF 3.0) Pub Date : 2023-11-13 Maria Irma Rodriguez Suarez,Cristine Naomi Ohara,Koody Andre Hassemi Kitawara,Welder Zamoner,Andre Luis Balbi,Daniela Ponce
INTRODUCTION Recovery of kidney function to liberate patients from acute kidney replacement therapy (AKRT) is recognized as a vital patient-centered outcome. The lack of specific guidelines providing specific recommendations on therapy interruption is an important obstacle. We aimed to determine the prevalence of successful discontinuation of AKRT and its predictive factors after the elaboration of
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Cytokine Adsorption Effects of a Novel Hemofiltration Column for the Treatment of Experimental Endotoxemia. Blood Purif. (IF 3.0) Pub Date : 2023-11-08 Takashi Yamamoto,Shun Kunomura,Takumi Taniguchi
INTRODUCTION The TKM-101 is a new hemofiltration column packed with a polymer alloy membrane consisting of polyethersulfone, polyvinylpyrrolidone, and sulfonated poly (arylene ether) copolymers. We examined the ability of the TKM-101 column to remove cytokines and humoral mediators from blood in vitro and the effects of extracorporeal treatment with the TKM-101 column on the mortality rate and inflammatory
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Removal of α1-Microglobulin Using Post-Dilution Online Hemodiafiltration with Polymethylmethacrylate Membrane: An Open-Label, Single-Arm Study. Blood Purif. (IF 3.0) Pub Date : 2023-11-08 Shiori Yoshida,Suguru Yamamoto,Daisuke Miyauchi,Ryohei Terashima,Atsushi Hashimoto,Haruna Miyazawa,Takahiro Tanaka,Masahiro Ishizawa,Mototsugu Tanaka,Yoshihiko Tomita,Ikuo Aoike,Shin Goto,Ichiei Narita
INTRODUCTION The removal of low- and medium-molecular-weight proteins has been improved with online hemodiafiltration (OL-HDF) and hemodialysis using high-flux membranes; however, the outcomes of patients with end-stage kidney disease (ESKD) undergoing dialysis treatment are still worse than in the general population. α1-Microglobulin (α1-m), with a molecular weight of 33,000 Da, may contribute to
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Nomenclature of Extracorporeal Blood Purification Therapies for Acute Indications: The Nomenclature Standardization Conference. Blood Purif. (IF 3.0) Pub Date : 2023-11-03 Marlies Ostermann,Ghada Ankawi,Vincenzo Cantaluppi,Rajasekara Madarasu,Kristin Dolan,Faeq Husain-Syed,Kianoush Kashani,Ravindra Mehta,John Prowle,Thiago Reis,Thomas Rimmelé,Alexander Zarbock,John A Kellum,Claudio Ronco,
The development of new extracorporeal blood purification (EBP) techniques has led to increased application in clinical practice but also inconsistencies in nomenclature and misunderstanding. In November 2022, an international consensus conference was held to establish consensus on the terminology of EBP therapies. It was agreed to define EBP therapies as techniques that use an extracorporeal circuit
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Hepcidin removal during Continuous Renal Replacement Therapy. Blood Purif. (IF 3.0) Pub Date : 2023-11-03 Jame F Colbert,Benjamin R Griffin,Kristy Rolloff,Christopher L Erzen,Sarah M Haeger,Chris Altmann,Kayo Okamura,Ruth Campbell,Isaac Teitelbaum,Sarah Faubel
INTRODUCTION Patients with acute kidney injury (AKI) or end stage kidney disease (ESKD) may require continuous renal replacement therapy (CRRT) as a supportive intervention. While CRRT is effective at achieving solute control and fluid balance, the indiscriminate nature of this procedure raises the possibility that beneficial substances may similarly be removed. Hepcidin, an antimicrobial peptide with
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Predictions of Serum Phosphate Concentration During CRRT Using a Steady State Mass Balance Model. Blood Purif. (IF 3.0) Pub Date : 2023-11-03 John K Leypoldt,Jorge Echeverri,Kai Harenski,Kuljinder Singh
INTRODUCTION Hypophosphatemia is common during continuous renal replacement therapy (CRRT), but serum phosphate levels can potentially be maintained during treatment by either intravenous phosphate supplementation or addition of phosphate to renal replacement therapy (RRT) solutions. METHODS We developed a steady state phosphate mass balance model to assess the effects of CRRT dose on serum phosphate
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The Clearance of Midazolam and Metabolites during Continuous Renal Replacement Therapy in Critically Ill Patients with COVID-19. Blood Purif. (IF 3.0) Pub Date : 2023-11-03 Tim J L Smeets,Hilde R H de Geus,Abraham J Valkenburg,Lauren Baidjoe,Diederik A M P J Gommers,Birgit C P Koch,Nicole G M Hunfeld,Henrik Endeman
INTRODUCTION Midazolam-based continuous intravenous sedation in patients admitted to the intensive care unit (ICU) was a necessity during the COVID-19 pandemic. However, benzodiazepine-based sedation is associated with a high incidence of benzodiazepine-related delirium and additional days on mechanical ventilation. Due to the requirement of high midazolam doses in combination with the impaired renal
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Efficacy of the Cytokine Adsorption Therapy in Patients with Severe COVID-19-Associated Pneumonia: Lesson Learned from a Prospective Observational Study. Blood Purif. (IF 3.0) Pub Date : 2023-11-02 Prit Kusirisin,Kajohnsak Noppakun,Konlawij Trongtrakul,Surachet Vongsanim,Yuttitham Suteeka,Vuddhidej Ophascharoensuk,Karn Pongsuwan,Phoom Narongkiatikhun,Theerakorn Theerakittikul,Nattayaporn Apaijai,Siriporn C Chattipakorn,Nipon Chattipakorn,Nattachai Srisawat
INTRODUCTION Severe COVID-19 pneumonia can activate a cytokine storm. Hemoperfusion can reduce pro-inflammatory cytokines in sepsis but is still debated in the COVID-19 setting. Thus, we sought to investigate the benefits of HA-330 cytokine adsorption through clinical and laboratory outcomes. METHODS We conducted a single-center prospective observational study in adults with severe COVID-19 pneumonia
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Comparison of different prediction models for unplanned interruption of CRRT treatment --A systematic review of qualitative analyses. Blood Purif. (IF 3.0) Pub Date : 2023-11-02 Yanting Zhang,Zhaoyang Li,Jin Li,Xinbo Ding,Jing Ma
INTRODUCTION In recent years, many researchers have developed or validated prediction models for unexpected interruption of CRRT for the above reasons. This study will systematically search and evaluate the prediction models for unplanned interruption of CRRT, and to provide a reference for building a higher quality prediction model for unplanned interruption of CRRT. METHODS PubMed, Embase, Cochrane
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Rapid and Effective Elimination of Myoglobin with CytoSorb® Hemoadsorber in Patients with Severe Rhabdomyolysis. Blood Purif. (IF 3.0) Pub Date : 2023-11-02 Frederic Albrecht,Stefan Schunk,Maren Fuchs,Thomas Volk,Juergen Geisel,Danilo Fliser,Andreas Meiser
INTRODUCTION Rhabdomyolysis is characterized by destruction of muscle fibers by various causes and is diagnosed by increased creatine kinase concentrations in the blood. Myoglobin released into the blood may cause acute kidney injury. In this randomized controlled study, we hypothesized that myoglobin elimination would be faster when a hemoadsorber was added to a continuous veno-venous hemodialysis
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Endotoxemia Correlates with Kidney Function and Length of Stay in Critically Ill Patients. Blood Purif. (IF 3.0) Pub Date : 2023-11-02 Sian E Piret,Sobia Khan,Fabliha Fairuz,Samaneh Gholami,Merin Davis,Chang Kyung Kim,Melissa Espinoza,Debra Foster,John A Kellum,Sahar Ahmad,Andreas P Kalogeropoulos,Sandeep K Mallipattu
INTRODUCTION Endotoxin is a key driver of sepsis, which frequently causes acute kidney injury (AKI). However, endotoxins may also be found in non-bacteremic critically ill patients, likely from intestinal translocation. Preclinical models show that endotoxins can directly injure the kidneys, and in COVID-19 patients, endotoxemia correlated with AKI. We sought to determine correlations between endotoxemia
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Application of Hemoperfusion in the Treatment of Acute Poisoning. Blood Purif. (IF 3.0) Pub Date : 2023-11-02 Jianting Ke,Yuting Wei,Binhuan Chen
Rescue of acute poisoning is a race against time, and it is particularly important to remove toxic substances in time. Traditional methods include gastric lavage, promoting elimination, chelating agents, and other treatments. Hemoperfusion is a common blood purification technique. In the clinical practice of acute poisoning, hemoperfusion can directly remove toxic substances through its unique adsorption
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The Impact of Early Positive Studies on the Evolution of Extracorporeal Albumin Dialysis Literature: A Bibliometric Analysis. Blood Purif. (IF 3.0) Pub Date : 2023-10-31 Anis Chaba,Stephen Warrillow,Caleb Fisher,Akinori Maeda,Sofia Spano,Rinaldo Bellomo
Background Liver failure is a life-threatening condition characterized by the accumulation of metabolic toxins. Extracorporeal albumin dialysis (ECAD) has been promoted as a possible therapy. Methods We employed bibliometric analysis to scrutinize the conceptual, intellectual, and social structure of the ECAD literature including its co-citation network and thematic analysis to explore its evolution
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Effects of Blood Hemoadsorption Therapy with HA-380 in Total Arch Replacement for Acute Type A Aortic Dissection:A Retrospective Observational Study. Blood Purif. (IF 3.0) Pub Date : 2023-10-30 Juxiang Wang,Bin Chen,Junhao Xie,Huilong Chen,Lihua Li,Weiqun Zhang,Lin Lu,Xijie Wu
INTRODUCTION This study aimed to evaluate whether the addition of a hemoadsorption (HA) cartridge, HA-380, in the cardiopulmonary bypass (CPB) circuit in acute type A aortic dissection (ATAAD) surgery reduced inflammatory cytokine levels and decreased postoperative complications. METHODS A retrospective observational cohort study was conducted between 1 March 2021 and 28 February 2022. Patients with
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Neurocognitive Function with Conventional Hemodialysis Versus Post-Dilution Hemofiltration as Initial Treatment in ESKD patients. A randomized controlled trial. The DA-VINCI Study. Blood Purif. (IF 3.0) Pub Date : 2023-10-27 Enzo Vasquez Jimenez,Guadalupe Campos Núñez,Abel Lerma,Claudia Lerma,Aloha Meave González,Hector Pérez-Grovas,Salvador López Gil,Magdalena Madero
INTRODUCTION The ideal modality choice and dialysis prescription during the first renal replacement therapy (RRT) session remains unclear. We conducted a pilot study to determine the safety risk for hemodialysis (HD) versus hemofiltration (HF) and its relationship with neurocognitive assessment on incident RRT patients. METHODS Twenty-four incident RRT patients were included. Patients were randomized
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Peritoneal Dialysis during the COVID-19 Pandemic Is an Effective Treatment in Developing Countries: A Report from Mexico. Blood Purif. (IF 3.0) Pub Date : 2023-10-25 Alberto Villa-Torres,Enzo Vásquez-Jiménez,Ricardo Iván Velazquez-Silva,Leticia Herrera-Arellano,Nayeli Acosta-García,Dolores Aleman-Quimbiulco,Ricardo Duarte-Pérez,Carlos A Carmona Bautista,José Manuel Rodríguez-Chagolla
INTRODUCTION During the height of the coronavirus disease-19 (COVID-19) pandemic, some renal replacement therapy (RRT) modalities were insufficient, forcing medical centers to diversify the RRT modalities offered. In this study, we reported the outcomes of chronic peritoneal dialysis (PD) patients and acute PD in critically ill patients during COVID-19 pandemic in a tertiary care medical center in
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Efficacy of Therapeutic Apheresis for Cryoglobulinemic Vasculitis Patients with Renal Involvement: A Systematic Review. Blood Purif. (IF 3.0) Pub Date : 2023-10-18 Jing Miao,Pajaree Krisanapan,Supawit Tangpanithandee,Charat Thongprayoon,Wisit Cheungpasitporn
INTRODUCTION Therapeutic apheresis (TA) is commonly used for cryoglobulinemic vasculitis (CV) patients, but its efficacy remains uncertain. This systematic review aimed to assess the efficacy of different TA modalities, such as plasma exchange (PE), plasmapheresis (PP), and cryofiltration (CF), in treating CV patients with renal involvement. METHODS Literature search of MEDLINE, EMBASE, and Cochrane
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Impact of Intensity of Continuous Renal Replacement Therapy on Duration of Ventilation in Critically Ill Patients: A Secondary Analysis of the RENAL Trial. Blood Purif. (IF 3.0) Pub Date : 2023-10-18 Ary Serpa Neto,Thummaporn Naorungroj,Martin Gallagher,Rinaldo Bellomo
INTRODUCTION More intensive renal replacement therapy (RRT) has been associated with prolonged mechanical ventilation (MV). However, such finding may be dependent on RRT modality. We hypothesized that, when using continuous renal replacement therapy (CRRT), RRT intensity would not be associated with prolonged MV. METHODS In a secondary analysis of the Randomized Evaluation of Normal versus Augmented
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COVID-19: The Dysregulated Response to Infection - Why Consider Polymethylmethacrylate Membrane in Hemodialysis Patients? Blood Purif. (IF 3.0) Pub Date : 2023-10-16 Andrea Spasiano,Gianmarco De Luca,Giulia Bartoli,Andrea Dello Strologo,Maria Arena,Giuseppe Grandaliano
Since SARS-CoV-2 spread through China at the end of 2019, COVID-19 has been probably the most difficult challenge in the last decades for healthcare systems all around the world, still representing a danger for fragile patients with different comorbidities. Chronic dialysis patients affected by COVID-19 experienced severe disease with a higher mortality rate compared to the general population. Morbidity
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Cardiac Output Changes during Renal Replacement Therapy: A Scoping Review. Blood Purif. (IF 3.0) Pub Date : 2023-10-14 Sofia Spano,Akinori Maeda,Joey Lam,Anis Chaba,Emily See,Peter Mount,Mina Nichols-Boyd,Rinaldo Bellomo
INTRODUCTION Renal Replacement Therapy (RRT) is associated with hypotension. However, its impact on cardiac output (CO) is less understood. We aimed to describe current knowledge of CO monitoring and changes during RRT. METHODS We searched Medline, Embase and Cochrane from 01/01/2000 to 31/01/2023 using Covidence for studies of intermittent hemodialysis (IHD) and continuous RRT (CRRT) with at least
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41st Vicenza Course on AKI & CRRT, 12-14 June 2023, Vicenza, Italy: Abstracts. Blood Purif. (IF 3.0) Pub Date : 2023-10-12 Gioia Vencato
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Different Roles of Functional and Structural Renal Markers Measured at Discontinuation of Renal Replacement Therapy for Acute Kidney Injury. Blood Purif. (IF 3.0) Pub Date : 2023-09-27 Teruhiko Yoshida,Ryo Matsuura,Yohei Komaru,Yoshihisa Miyamoto,Kohei Yoshimoto,Yoshifumi Hamasaki,Eisei Noiri,Masaomi Nangaku,Kent Doi
INTRODUCTION Severe acute kidney injury (AKI) requiring renal replacement therapy (RRT) has been associated with an unacceptably high mortality of 50% or more. Successful discontinuation of RRT is thought to be linked to better outcomes. Although functional and structural renal markers have been evaluated in AKI, little is known about their roles in predicting outcomes at the time of RRT discontinuation
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Novel Approach to Intradialytic Progressive Resistance Exercise Training. Blood Purif. (IF 3.0) Pub Date : 2023-09-22 Daniela Filipa Cardoso,Diogo Vaz Leal,Pedro Martins,Eduardo Andre Abade,Henrique Coelho Rocha,Manuel Ferreira,Luke Alexander Baker,Alice C Smith,João L Viana
Physical activity levels are typically undesirably low in chronic kidney disease patients, especially in those undergoing haemodialysis, and particularly on dialysis days. Intradialytic exercise programmes could be a solution to this issue and have been reported to be safe and relatively easily implemented in dialysis clinics. Nevertheless, such implementation has been failing in part due to barriers
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Proceedings of the 2022 UAB CRRT Academy: Non-Invasive Hemodynamic Monitoring to Guide Fluid Removal with CRRT and Proliferation of Extracorporeal Blood Purification Devices. Blood Purif. (IF 3.0) Pub Date : 2023-09-22 J Pedro Teixeira,Amanda Zeidman,William Beaubien-Souligny,Jorge Cerdá,Michael J Connor,Katrina Eggleston,Luis A Juncos,J Ricardo da Silva,Catherine Wells,Lenar Yessayan,Andrew B Barker,Wendy McConville,Rajesh Speer,Keith M Wille,Javier A Neyra,Ashita Tolwani
In 2022, we celebrated the 15th anniversary of the University of Alabama at Birmingham (UAB) Continuous Renal Replacement Therapy (CRRT) Academy, a 2-day conference attended yearly by an international audience of over 100 nephrology, critical care, and multidisciplinary trainees and practitioners. This year, we introduce the proceedings of the UAB CRRT Academy, a yearly review of select emerging topics
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The Good, the Bad, and the Serum Creatinine: Exploring the Effect of Muscle Mass and Nutrition. Blood Purif. (IF 3.0) Pub Date : 2023-09-22 Silvia De Rosa,Massimiliano Greco,Michela Rauseo,Maria Giuseppina Annetta
Muscle wasting (sarcopenia) is one of the hallmarks of critical illness. Patients admitted to intensive care unit develop sarcopenia through increased protein catabolism, a decrease in protein syntheses, or both. Among the factors known to promote wasting are chronic inflammation and cytokine imbalance, insulin resistance, hypermetabolism, and malnutrition. Moreover, muscle wasting, known to develop
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Expanding the Spectrum of Extracorporeal Strategies in Small Infants with Hyperammonemia. Blood Purif. (IF 3.0) Pub Date : 2023-09-19 Giovanni Ceschia,Mattia Parolin,Germana Longo,Claudio Ronco,Enrico Vidal
Hyperammonemia is a life-threatening condition mainly due to the neurotoxicity of ammonia. Ammonia scavengers may be insufficient, and extracorporeal treatment may be required. Continuous treatments are preferred, and a high-dose continuous renal replacement therapy (CRRT) must be prescribed to ensure a fast ammonia depletion. Many of the children with hyperammonemia are newborns, with lower blood
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The Effects of Dialysis Modality and Emotional Distress on Fatigue in Patients Undergoing Dialysis. Blood Purif. (IF 3.0) Pub Date : 2023-09-13 Qin Ouyang,Fengjie Yang,Hong Wu,Shiqi Tang,Xinyue Peng,Yuxin Li,Jianwen Wang
INTRODUCTION Fatigue is a common but often overlooked symptom in dialysis patients. Factors affecting fatigue in dialysis patients are currently unclear. There are few studies on the effects of mental factors and dialysis modality on fatigue. This study aims to explore the potential relationship between fatigue and insomnia, as well as psychiatric disorders such as anxiety and depression among patients
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Induction of Vesicular Trafficking and JNK-Mediated Apoptotic Signaling in Mononuclear Leukocytes Marks the Immuno-Proteostasis Response to Uremic Proteins. Blood Purif. (IF 3.0) Pub Date : 2023-09-13 Desirée Bartolini,Maria Antonietta Grignano,Marta Piroddi,Elisabetta Chiaradia,Gabriele Galeazzi,Mario Rende,Claudio Ronco,Teresa Rampino,Carmelo Libetta,Francesco Galli
INTRODUCTION Uremic retention solutes have been alleged to induce the apoptotic program of different cell types, including peripheral blood mononuclear leukocytes (PBL), which may contribute to uremic leukopenia and immune dysfunction. METHODS The molecular effects of these solutes were investigated in uremic PBL (u-PBL) and mononuclear cell lines (THP-1 and K562) exposed to the high molecular weight
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Standardization of Nomenclature for the Mechanisms and Materials Utilized for Extracorporeal Blood Purification. Blood Purif. (IF 3.0) Pub Date : 2023-09-13 Thiago Reis,Danielle E Soranno,William Clark,Silvia De Rosa,Lui G Forni,Anna Lorenzin,Zaccaria Ricci,Gianluca Villa,Claudio Ronco,John A Kellum,Ravindra Mehta,Mitchell H Rosner,
In order to develop a standardized nomenclature for the mechanisms and materials utilized during extracorporeal blood purification, a consensus expert conference was convened in November 2022. Standardized nomenclature serves as a common language for reporting research findings, new device development, and education. It is also critically important to support patient safety, allow comparisons between
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Calcium-Citrate Anticoagulation during Continuous Renal Replacement Therapy in Patients with Metformin Intoxication: A Case Series, Mathematical Estimation of Citrate Accumulation, and Literature Review. Blood Purif. (IF 3.0) Pub Date : 2023-09-06 Beatrice Brunoni,Francesco Zadek,Francesca Mulazzani,Giovanni Verza,Francesco Marrazzo,Stefano Spina,Alessandro Protti,Roberto Fumagalli,Thomas Langer
INTRODUCTION Metformin intoxication causes lactic acidosis by inhibiting Krebs' cycle and oxidative phosphorylation. Continuous renal replacement therapy (CRRT) is recommended for metformin removal in critically ill patients. According to current guidelines, regional citrate anticoagulation (RCA) is the first-line strategy. However, since metformin also inhibits citrate metabolism, a risk of citrate
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Extracorporeal Blood Purification with CytoSorb in 359 Critically Ill Patients. Blood Purif. (IF 3.0) Pub Date : 2023-09-05 Marina Pieri,Matteo A Bonizzoni,Alessandro Belletti,Maria G Calabrò,Evgeny Fominskiy,Pasquale Nardelli,Alessandro Ortalda,Anna M Scandroglio
INTRODUCTION Critically ill patients with inflammatory dysregulation and organ disfunction may benefit from blood purification, although the use of this technique has not been described in large case series. We evaluated clinical outcomes and survival in high-risk intensive care unit (ICU) patients who underwent extracorporeal blood purification. METHODS 359 consecutive ICU patients treated with CytoSorb
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Chronic Kidney Disease-Associated Pruritus: Nomenclature and Treatment - We Need to Take Two Steps Forward. Blood Purif. (IF 3.0) Pub Date : 2023-09-04 Gonzalo Ramírez-Guerrero,Claudio Ronco,Thiago Reis
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The Role of Erythropoietin Levels in Predicting Long-Term Outcomes following Severe Acute Kidney Injury. Blood Purif. (IF 3.0) Pub Date : 2023-08-29 Prit Kusirisin,Peerapat Thanapongsatorn,Kamolthip Chaikomon,Nuttha Lumlertgul,Khanittha Yimsangyad,Akarathep Leewongworasingh,Phatadon Sirivongrangson,Sadudee Peerapornratana,Weerachai Chaijamorn,Yingyos Avihingsanon,Nattachai Srisawat
INTRODUCTION Acute kidney injury (AKI) survivors are at an increased risk of chronic kidney disease, end-stage kidney disease, and mortality. Little is known about the effect of erythropoietin (EPO), a kidney-producing hormone, in post-AKI setting. We aimed to investigate the role of EPO as a predictor of long-term outcomes in post-severe AKI survivors. METHODS We performed a retrospective analysis
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Methemoglobinemia in Hemodialysis Patients due to Acute Chlorine Intoxication: A Case Series Calling Attention on an Old Problem. Blood Purif. (IF 3.0) Pub Date : 2023-08-28 Jonathan S Chávez-Iñiguez,Ramón Medina-González,Ana Ron-Magaña,Magdalena Madero,Amanda C Ramírez-Ramírez,Brian S Rifkin,Eduardo Torres-Vázquez,Gael Chávez-Alonso,Juan A Gómez-Fregoso,Gonzalo Rodríguez-García,Alexa N Oseguera-González,Edgar J Carmona-Morales,Cesar Murguia-Soto,Karina Renoirte-López,Guillermo García-García
INTRODUCTION Hemodialysis uses municipal water that must be strictly purified and sterilized to be used for that procedure. Large amounts of decontaminants are often used, such as chlorine, and if these compounds are not subsequently removed they can be transferred to the blood of patients causing complications including methemoglobinemia. METHODS In this case series study, dialysis patients in one
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With Single Plasma Exchange, a Better Understanding of the Potential Clinical Effects of Albumin Replacement Is Required. Blood Purif. (IF 3.0) Pub Date : 2023-08-23 Olivier Moranne,Jean-Paul Cristol
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Hemolytic Uremic Syndrome-Induced Acute Kidney Injury Treated via Immunomodulation with the Selective Cytopheretic Device. Blood Purif. (IF 3.0) Pub Date : 2023-08-22 H Rhodes Hambrick,Kara Short,David Askenazi,Kelli Krallman,Christopher Pino,Lenar Yessayan,Angela Westover,H David Humes,Stuart L Goldstein
INTRODUCTION Shiga-toxin associated-hemolytic uremic syndrome (STEC-HUS) is a severe cause of acute kidney injury (AKI) in children. Although most children recover, about 5% die and 30% develop chronic renal morbidity. HUS pathophysiology includes activated neutrophils damaging vascular endothelial cells. Therapeutic immunomodulation of activated neutrophils may alter the progression of disease. We
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Low Blood Glucose Index Associated with Cardiovascular Events in Diabetic Hemodialysis Patients. Blood Purif. (IF 3.0) Pub Date : 2023-08-22 Ruibin He,Yingli Xuan,Lingling Zhu,Shiqing Pang,Li Qin,Jingyan Tian,Jiangzi Yuan
INTRODUCTION Blood glucose monitoring was vitally important in diabetic kidney disease (DKD) patients for preventing complications and improving survival rates. The associations between glycemic variability and blood biochemical indicators were underestimated in patients with DKD undergoing hemodialysis. Therefore, we primarily aimed to investigate the glycemic variability and 1-year risk of cardiovascular
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Comparative Efficacy and Acceptability of 12 Phosphorus-Lowering Drugs in Adults with Hyperphosphatemia and Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis. Blood Purif. (IF 3.0) Pub Date : 2023-08-17 Houli Luo,Jian Feng,Gang Xue,Yanbiao Zhang,Yunming Li,Xi Huang,Xin Chen,Shuang You,Hongfei Dong,Lingfan Li,Juncheng Li,Hualin Xiao,Xiang Ai,Xianhui Li,Bo Huang
BACKGROUND Hyperphosphatemia is associated with cardiovascular morbidity and mortality in adults with chronic kidney disease (CKD). Drug therapy has an irreplaceable role in the management of hyperphosphatemia. OBJECTIVES We aimed to compare and rank phosphorus-lowering drugs, including phosphate binder and nonphosphate binder, in hyperphosphatemia adults with CKD. METHODS We did a systematic review
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Interleukin-10: A Potential Pre-Cannulation Marker for Development of Acute Kidney Injury in Patients Receiving Veno-Arterial Extracorporeal Membrane Oxygenation. Blood Purif. (IF 3.0) Pub Date : 2023-08-16 Edgars Grins,Marzia Leacche,Nabin Manandhar Shrestha,Henrik Bjursten,Per Ederoth,Stefan Jovinge
INTRODUCTION Acute kidney injury (AKI) in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is associated with high mortality. The objective of this study was to investigate whether cytokine levels before the initiation of ECMO treatment could predict AKI. We also aimed to investigate the impact of AKI on 30-day and 1-year mortality. METHODS Serum cytokine levels were
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Impact of Hemodialysis on Left Ventricular-Arterial Coupling in End-Stage Renal Disease Patients. Blood Purif. (IF 3.0) Pub Date : 2023-08-14 Ming-Liang Zuo,Qiu-Yi Chen,Lei Pu,Lan Shi,Dan Wu,Hua Li,Xian Luo,Li-Xue Yin,Chung-Wah Siu,Da-Qing Hong,Hua Gan
INTRODUCTION As a key determinant of cardiovascular performance, vascular-arterial coupling (VAC) has been reported to be a predictor of clinical outcomes in various clinical scenarios. However, few studies have explored how acute fluid removal during hemodialysis (HD) impacts the interaction between cardiac function and the arterial system. METHODS We recruited 317 HD patients from an established
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Feasibility, Efficacy, and Safety of Peripheral Venous Access for Chronic Double-Filtration Plasmapheresis with Regional Citrate Anticoagulation. Blood Purif. (IF 3.0) Pub Date : 2023-08-03 Antoine Cardinale,Emilie Pambrun,Camelia Prelipcean,Ziyad Messikh,Olivier Moranne
INTRODUCTION Peripheral venous access (PVA) is recommended as a first-line vascular approach for therapeutic plasmapheresis with centrifugation methods but not filtration, which usually requires high blood flow. We evaluated the feasibility, efficacy, and safety of double-filtration plasmapheresis (DFPP) with PVA, using ultrasound guidance and regional citrate anticoagulation (RCA), i.e., PVA-RCA-DFPP
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Sequential Extracorporeal Blood Purification Is Associated with Prolonged Survival among ICU Patients with COVID-19 and Confirmed Bacterial Superinfection. Blood Purif. (IF 3.0) Pub Date : 2023-07-21 Vedran Premuzic,Ivan Situm,Daniel Lovric,Ante Erceg,Dora Karmelic,Mate Mogus,Matija Jurjevic,Vanja Nedeljkovic,Mirabel Mazar,Slobodan Mihaljevic,Gianluca Villa,Claudio Ronco
INTRODUCTION This study investigates the impact of sequential extracorporeal treatments with oXiris® or CytoSorb® plus Seraph-100® on the clinical and laboratory parameters of critically ill COVID-19 patients with bacterial superinfection. METHODS Patients admitted to the intensive care unit with COVID-19, bacterial superinfection, and undergoing blood purification (BP) were enrolled in this prospective
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Improved β2-Microglobulin and Phosphorous Removal with Expanded Hemodialysis and Online Hemodiafiltration versus High-Flux Hemodialysis: A Cross-Over Randomized Clinical Trial. Blood Purif. (IF 3.0) Pub Date : 2023-07-20 Olynka Vega-Vega,Adrián E Caballero-Islas,Noemí Del Toro-Cisneros,Sergio Óscar Hernandez-Ordoñez,Mauricio Arvizu-Hernández,Armando Martínez-Rueda,Diana Camacho-Colin,Leidi Laura Gómez-Correa,Ricardo Correa-Rotter
INTRODUCTION Expanded hemodialysis (HDx) is expected to provide enhanced permeability of medium-sized molecules, selective solute retention, and better internal retrofiltration. The primary objective of this study was to compare the efficiency for removal of β2-microglobulin with 3 different extracorporeal therapies (ETs): high-flux hemodialysis (HF), online hemodiafiltration (OL-HDF), and HDx. The
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Association of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors with Cardiovascular Events and Death in Dialysis Patients: A Systematic Review and Meta-Analysis. Blood Purif. (IF 3.0) Pub Date : 2023-07-17 Maria Gabriela Motta Guimarães,Fernanda Pinheiro Martin Tapioca,Felipe Costa Neves,José A Moura-Neto,Luiz Carlos Santana Passos
BACKGROUND Anemia is a common finding among patients with advanced chronic kidney disease, especially those on dialysis. The recent introduction of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) has raised some concerns about the cardiovascular and thrombotic complications of this class of drugs. OBJECTIVES This meta-analysis aimed to assess the safety of HIF-PHIs in patients with
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Dialysis in Pregnancy: An Update Review. Blood Purif. (IF 3.0) Pub Date : 2023-06-28 Sidar Copur,Metehan Berkkan,Carlo Basile,Mario Cozzolino,Mehmet Kanbay
Chronic kidney disease and end-stage kidney disease (ESKD) are important public health problems with increased rates of morbidity, mortality, and social costs. Pregnancy is rare in patients with ESKD, with reduced fertility rates in women undergoing dialysis. Although current advances have led to an increase in live births in pregnant dialysis patients, this modality still has an increased risk of
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Practical Utilization of Prediction Equations in Chronic Kidney Disease. Blood Purif. (IF 3.0) Pub Date : 2023-06-21 Navdeep Tangri,Thomas W Ferguson
Chronic kidney disease (CKD) is common and can lead to kidney failure, cardiovascular complications, and early mortality. While nephrologists can provide valuable insights for patients at all stages of CKD, these scarce resources should be targeted at patients with the highest risk of progression and adverse outcomes. Prediction models are tools that can help providers risk stratify patients if they
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HMGB1 Is a Prognostic Factor for Mortality in Acute Kidney Injury Requiring Renal Replacement Therapy. Blood Purif. (IF 3.0) Pub Date : 2023-06-19 Ryo Matsuura,Yohei Komaru,Yoshihisa Miyamoto,Teruhiko Yoshida,Kohei Yoshimoto,Tetsushi Yamashita,Yoshifumi Hamasaki,Eisei Noiri,Masaomi Nangaku,Kent Doi
INSTRUCTION High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that reportedly causes kidney injury and other organ damage in rodent acute kidney injury (AKI) models. However, it remains unclear whether HMGB1 is associated with clinical AKI and related outcomes. This study aimed to evaluate the association with HMGB1 and prognosis of AKI requiring continuous renal replacement therapy
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Association between Serum C-Reactive Protein Concentrations and Risk of Cancer-Related Mortality in Patients Undergoing Hemodialysis: 10-Year Outcomes of the Q-Cohort Study. Blood Purif. (IF 3.0) Pub Date : 2023-06-16 Yushi Uchida,Toshiaki Nakano,Hiroto Hiyamuta,Hiromasa Kitamura,Masatomo Taniguchi,Hiroaki Ooboshi,Kazuhiko Tsuruya,Takanari Kitazono
INTRODUCTION Cancer constitutes a major source of morbidity and mortality among people undergoing hemodialysis (HD). A systemic inflammatory response is associated with the incidence and prognosis of cancer in the general population. However, the effect of systemic inflammation on cancer-related mortality in patients undergoing HD remains unclear. METHODS We analyzed 3,139 patients registered in the
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A New Cycler for Automated Peritoneal Dialysis to Provide Efficient Dialysis and Improved Sleep Quality. Blood Purif. (IF 3.0) Pub Date : 2023-06-16 Rubén Torres,Lorena Flores,Miguel Morales,Rina Morales,Eduardo Machuca,Adelheid Gauly,Saynab Atiye,Manuela Stauss-Grabo,Tatiana De Los Ríos
INTRODUCTION Automated peritoneal dialysis (APD) employs cyclers to control inflow and outflow of the dialysis fluid to the patient's abdomen. To allow more patients to use this modality, cyclers should support the achievement of an adequate dialysis dose and be easy to use, cost-effective, and silent. The new SILENCIA cycler (Fresenius Medical Care, Bad Homburg, Germany), designed to improve these
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Role of the CD40-CD40 Ligand Pathway in Cardiovascular Events, Neurological Alterations, and Other Clinical Complications of Chronic Hemodialysis Patients: Protective Role of Adsorptive Membranes. Blood Purif. (IF 3.0) Pub Date : 2023-06-16 Marita Marengo,Massimiliano Migliori,Guido Merlotti,Paolo Fabbrini,Vincenzo Panichi,Vincenzo Cantaluppi
Despite the recent advances in dialysis technology, mortality rate of chronic uremic patients still remains excessively high: of note, in comparison to age- and sex-matched healthy controls, this frail population shows a higher incidence of infections, cancer, cognitive decline, and, in particular, major adverse cardiovascular events (MACE) that represent nowadays the first cause of mortality. Several
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The Association between Serum Chemerin and Peritoneal Membrane Transport Function in Patients Undergoing Incident Peritoneal Dialysis: A Prospective Cohort Study. Blood Purif. (IF 3.0) Pub Date : 2023-06-15 Zhiyun Zang,XiaoFang Wu,Dengyan Ma,Xiaoxiao Xia,Xueqin He,Xiaolei Chen,Zi Li
INTRODUCTION Some biomarkers in drained dialyzate or peritoneal membrane have been found related to the dialyzate/plasma ratio of creatinine at 4 h (D/P Cr) in patients undergoing peritoneal dialysis (PD). But so far, there is no report on serum markers. Some biomarkers are associated with cardiovascular diseases (CVDs). Chemerin is a multifunctional chemoattractant adipokine which plays important