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Central venoplasty followed by 'double guidewire railroad technique' as a bailout strategy in difficult tunnelled dialysis catheter insertion. Nephrology (IF 2.4) Pub Date : 2024-09-24 Shabna Sulaiman,Abdul Razik
End-stage renal disease (ESRD) patients frequently encounter challenges at the time of dialysis catheter insertion from concomitantly associated with thoracic central venous obstruction (TCVO). TCVO complicates the placement of tunnelled dialysis catheters (TDCs). In cases where TCVO is unexpectedly encountered and TDC insertion becomes difficult, central venoplasty followed by catheter reinsertion
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Trends of bone mineral density and bone quality in a paediatric kidney transplant recipient: A case report. Nephrology (IF 2.4) Pub Date : 2024-09-24 Jun Aoyagi,Takahiro Kanai,Takane Ito,Takashi Saito,Hiroyuki Betsui,Masanori Kurosaki,Tomomi Maru,Marika Ono,Toshihiro Tajima
Kidney transplant (KT) requires long-term glucocorticoid (GC) treatment against acute and/or chronic rejection. Glucocorticoid-induced osteoporosis (GIOP) is one of the major concerns in kidney transplant recipients (KTRs). Therefore, it is essential to accumulate GIOP data from paediatric KTRs to aid in their healthy growth. A serial observational study of bone strength was carried out in an 8-year-old
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A case report of minimal change disease associated with Kimura disease complicated by optic neuritis Nephrology (IF 2.4) Pub Date : 2024-09-23 Fumiaki Tanemoto, Imari Mimura, Masaomi Nangaku
Kimura disease (KD) is a rare chronic inflammatory disease that typically presents with soft subcutaneous granulomas in the head and neck regions characterized by elevated blood eosinophils and immunoglobulin E (IgE) level, whose aetiology remains poorly elucidated. Minimal change disease (MCD) has been reported as one of the renal manifestations that KD can present with, indicating that they may share
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A rare multisystemic disorder with chronic kidney disease: Karyomegalic interstitial nephritis due to homozygous FAN1 c.2260C>T variant Nephrology (IF 2.4) Pub Date : 2024-09-19 Merve Guzel Dirim, Ahmet Burak Dirim, Berker Kaya, Naci Senkal, Tugba Kalayci, Ayca Aslanger, Neslihan Berker, Murat Kose, Isin Kilicaslan, Halil Yazici
Karyomegalic interstitial nephritis (KIN) is a rare entity associated with biallelic FAN1 (FANCD2/FANCI‐Associated Nuclease 1) gene variants. In FAN1‐related KIN, abnormal liver function tests and respiratory involvement are common, in addition to chronic kidney disease. Karyomegalic changes have also been reported in many other organs in patients with FAN1‐related KIN in various studies. We report
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Nephrotic syndrome in a child with neurofibromatosis type 1: A case report and literature review Nephrology (IF 2.4) Pub Date : 2024-09-18 Bingjie Cheng, Huihui Yang, Lin Huang, Panli Liao, Fei Peng, Xiaowen Wang
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that caused by NF1 mutations. NF1 gene encodes neurofibromin (a GTPase‐activating protein) and plays a regulatory role in many signalling pathway such as the Ras/MAPK pathway, which is important for regulating cell growth, proliferation and neural development. Therefore, NF1 gene mutations causes the excessive activation of signalling
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Sepsis-associated acute kidney injury in patients with chronic kidney disease: Patient characteristics, prevalence, timing, trajectory, treatment and associated outcomes. Nephrology (IF 2.4) Pub Date : 2024-09-18 Kyle C White,Rinaldo Bellomo,Alexis Tabah,Antony G Attokaran,Hayden White,James McCullough,Kiran Shekar,Mahesh Ramanan,Peter Garrett,Philippa McIlroy,Siva Senthuran,Stephen Luke,Ary Serpa-Neto,Tom Larsen,Kevin B Laupland,
AIM The features and outcomes of sepsis-associated acute kidney injury (SA-AKI) may be affected by chronic kidney disease (CKD). Accordingly, we aimed to compare SA-AKI in patients with or without CKD. METHODS Retrospective cohort study in 12 intensive care units (ICU). We studied the prevalence, patient characteristics, timing, trajectory, treatment and outcomes of SA-AKI with and without CKD. RESULTS
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SLC12A1 variant c.1684+1 G>A causes Bartter syndrome type 1 by promoting exon 13 skipping Nephrology (IF 2.4) Pub Date : 2024-09-11 Wenke Yang, Yanjun Li, Zhenglong Guo, Yanxin Ren, Jianmei Huang, Huiru Zhao, Shixiu Liao
BackgroundBartter syndrome type 1, an autosomal recessive genetic disorder, is caused by pathogenic loss‐of‐function variants in the SLC12A1 gene. It is characterized by metabolic alkalosis and prenatal‐onset polyuria leading to polyhydramnios.MethodsWe identified pathogenic gene in a 12‐day‐old newborn boy with Bartter syndrome type 1 using whole‐exome sequencing. Sanger sequencing validated the identified
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Hydrogen sulfide as a therapeutic agent in renal ischemia‐reperfusion injury: Mechanistic insights and clinical potential Nephrology (IF 2.4) Pub Date : 2024-09-11 Chih‐Ning Chen, Vin‐Cent Wu
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Autosomal dominant nephrogenic diabetes insipidus in one family caused by a novel AQP2 mutation Nephrology (IF 2.4) Pub Date : 2024-09-11 Hou‐Xuan Huang, Monika Sullivan, Paola Zayas Borges, Sabina Kennedy
A 9‐month‐old male presented with vomiting and dehydration with mild hypernatremia in the context of failure to thrive. He was later diagnosed with nephrogenic diabetes insipidus (NDI) during this hospitalisation and was also found to have eosinophilic esophagitis (EoE). He has since been growing well after EoE and NDI were properly managed. Molecular genetic testing revealed an unreported deletion
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The risk factor for adverse pregnancy outcomes and its impact on clinical effect in IgA nephropathy: A retrospective observational study Nephrology (IF 2.4) Pub Date : 2024-09-10 Fengxia Zhang, Zhiyong Xie, Siqi Peng, Nan Jiang, Bohou Li, Boxi Chen, Shuting Deng, Ye Yuan, Qiong Wu, Sichun Wen, Yiming Tao, Jianchao Ma, Sijia Li, Ting Lin, Feng Wen, Zhuo Li, Renwei Huang, Zhonglin Feng, Chaosheng He, Wenjian Wang, Xinling Liang, Lixia Xu, Yue Shen, Niechao Hong, Ruiquan Xu, Shuangxin Liu
AimIgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Pregnant IgAN patients are more susceptible to adverse pregnancy outcomes (APO). However, the risk factor for APO and its effects on the long‐term renal outcome of pregnant IgAN patients remained unclear.MethodsWe performed a retrospective observational study covering 2003–2019 that included 44 female IgAN patients with
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Impact of single centre kidney‐exchange transplantation to increase living donor pool in India: A cohort study involving non‐anonymous allocation Nephrology (IF 2.4) Pub Date : 2024-09-08 Vivek B. Kute, Himanshu V. Patel, Subho Banerjee, Divyesh P. Engineer, Ruchir B. Dave, Nauka Shah, Sanshriti Chauhan, Harishankar Meshram, Priyash Tambi, Akash Shah, Khushboo Saxena, Manish Balwani, Vishal Parmar, Shivam Shah, Ved Prakash, Sudeep Patel, Dev Patel, Sudeep Desai, Jamal Rizvi, Harsh Patel, Beena Parikh, Kamal Kanodia, Shruti Gandhi, Michael A. Rees, Alvin E. Roth, Pranjal Modi
AimIn India, 85% of organ donations are from living donors and 15% are from deceased donors. One‐third of living donors were rejected because of ABO or HLA incompatibility. Kidney exchange transplantation (KET) is a cost‐effective and legal strategy to increase living donor kidney transplantation (LDKT) by 25%–35%.MethodsWe report our experience with 539 KET cases and the evolution of a single‐centre
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An unusual case of Herbaspirillum huttiense bacteraemia in a haemodialysis patient Nephrology (IF 2.4) Pub Date : 2024-09-04 Andrew M. Fordyce, Frederiek Heenan‐Vos, Tracey L. Putt, Sine Donnellan, John W. B. Schollum, Robert J. Walker
Herbaspirillum spp. is a common environmental bacterium usually found in soil, plant roots, and water. It is rarely associated with infection in immunocompromised patients, and rarely reported infections in immunocompetent patients. We report the first case of a Herbaspirillum huttiense bacteraemia in a non‐neutropenic home haemodialysis patient. A 57‐year‐old male presented to our hospital with a
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PPAR gamma and PGC‐1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF‐kappaB activation Nephrology (IF 2.4) Pub Date : 2024-09-04 Siyi Huang, Yuanmeng Jin, Liwen Zhang, Ying Zhou, Nan Chen, Weiming Wang
AimInflammation plays a critical role in the progression of diabetic nephropathy. Peroxisome proliferator‐activated receptor gamma (PPARγ) and its coactivator PPARγ coactivator‐1 alpha (PGC‐1α) enhance mitochondrial biogenesis and cellular energy metabolism but inhibit inflammation. However, the molecular mechanism through which these two proteins cooperate in the kidney remains unclear. The aim of
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Is there an editorial glass ceiling? Editorial leadership in nephrology and transplantation journals: A gender‐based cross‐sectional analysis Nephrology (IF 2.4) Pub Date : 2024-08-30 Rose‐Marie Scarlato, Kate Wyburn, Melanie L. Wyld
AimEditors‐in‐Chief (EiC) play a key role as gatekeepers in academic medicine, often shaping research agendas. Women have historically been underrepresented in editorial leadership roles in academic medicine. The purpose of this study was to examine gender representation among EiC of contemporary transplantation and nephrology journals.MethodsThis cross‐sectional study evaluated gender disparities
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ANZSN Program at a Glance 59th Australian and New Zealand Society of Nephrology Annual Scientific Meeting 2024 Nephrology (IF 2.4) Pub Date : 2024-08-26
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ANZSN Council Office Bearers of the Australian and New Zealand Society of Nephrology Nephrology (IF 2.4) Pub Date : 2024-08-26
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Assessment of the causal relationship between inflammatory bowel diseases and chronic kidney diseases: A two‐sample bidirectional mendelian randomization study among European population Nephrology (IF 2.4) Pub Date : 2024-08-22 Xingxing Li, Qiaoyue Ge, Chuan Yu, Wenting Zhao, Chenxin Wu, Zhenmi Liu, Xiandong Meng, Chenghan Xiao
BackgroundKidney function can be impaired in patients with inflammatory bowel diseases (IBD), including Crohn's diseases (CD) and ulcerative colitis (UC). However, the causal relationship between IBD and chronic kidney diseases (CKD) remains unclear.MethodsWe determined the causal association between IBD and CKD by performing two‐sample bidirectional mendelian randomization (MR) analyses. Independent
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Antineutrophil cytoplasmic antibody‐negative pauci‐immune glomerulonephritis in a patient with Waldenstrom macroglobulinaemia Nephrology (IF 2.4) Pub Date : 2024-08-16 Wai Au‐Yang, Tai Yiu Cheung, Hui Yiu Chan, Wah Cheuk, Chi Yuen Cheung
Waldenstrom macroglobulinaemia (WM), the predominant subtype of lymphoplasmacytic lymphoma with bone marrow involvement and serum IgM paraprotein, is a haematological condition commonly associated with renal parenchymal involvement. However, antineutrophil cytoplasmic antibody (ANCA)‐negative pauci‐immune crescentic glomerulonephritis (PICGN) in kidney infiltrated by lymphoma is very rare, with only
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Deep learning radiomics based on ultrasound images for the assisted diagnosis of chronic kidney disease Nephrology (IF 2.4) Pub Date : 2024-08-13 Shuyuan Tian, Yonghong Yu, Kangjian Shi, Yunwen Jiang, Huachun Song, Yuting Wang, Xiaoqian Yan, Yu Zhong, Guoliang Shao
AimThis study aimed to explore the value of ultrasound (US) images in chronic kidney disease (CKD) screening by constructing a CKD screening model based on grey‐scale US images.MethodsAccording to the CKD diagnostic criteria, 1049 patients from Tongde Hospital of Zhejiang Province were retrospectively enrolled in the study. A total of 4365 renal US images were collected from these patients. Convolutional
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Rutin reduces inflammation and fibrosis via TGF‐β/SMAD pathways in IgA nephropathy induced rats Nephrology (IF 2.4) Pub Date : 2024-08-08 Rajiv Jash, Himangshu Sekhar Maji, Arnab Chowdhury, Sayak Biswas, Kousik Maparu, Robina Khatun, Suddhasattya Dey
AimRutin is a flavonoid glycoside obtained from the plant Ruta graveolens. It was known to have immunosuppressant activities. This study was focused on effect of rutin against immunoglobulin A (IgA) nephropathy.MethodsIgA nephropathy was induced in Sprague–Dawley rats with various inducing agents described in text. During the later part of the induction phase, rutin was administered. Control group
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Leukocytoclastic vasculitis as a presenting symptom of immunotactoid glomerulopathy Nephrology (IF 2.4) Pub Date : 2024-08-02 Suwasin Udomkarnjananun, Chalermchon Suttaluang, Jerasit Surintrspanont, Talerngsak Kanjanabuch
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Insights into SLC7A11 levels and vascular calcification in maintenance peritoneal dialysis patients Nephrology (IF 2.4) Pub Date : 2024-07-31 Lianwei Zhou, Yuhe Xing, Wenbo Li
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Successful treatment with rituximab in anti‐phospholipid syndrome nephropathy associated with systemic lupus erythematosus: A case report and literature review Nephrology (IF 2.4) Pub Date : 2024-07-31 Ji‐Young Choi, Eon Jeong Nam, Man‐hoon Han, Yong‐Jin Kim, Jeong‐Hoon Lim, Hee‐Yeon Jung, Jang‐Hee Cho, Chan‐Duck Kim, Yong‐Lim Kim, Sun‐Hee Park
Anti‐phospholipid syndrome (APS) nephropathy is an autoimmune disease that is sometimes accompanied by systemic lupus erythematosus (SLE). Here, we report the use of rituximab to treat a case of APS nephropathy in a SLE patient with recurrent vascular thrombosis. A 52‐year‐old woman, who had been diagnosed with SLE 11 years earlier, was referred to a nephrology clinic for evaluation of azotaemia and
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Hydrogen sulphide reduces renal ischemia‐reperfusion injury by enhancing autophagy and reducing oxidative stress Nephrology (IF 2.4) Pub Date : 2024-07-30 Hui Li, Shuaiwei Wang, Shuangshuang An, Biao Gao, Dongdong Wu, Yanzhang Li
AimRenal ischemia‐reperfusion injury (IRI) is a major cause of acute kidney injury. Hydrogen sulphide (H2S) exerts a protective effect in renal IRI. The present study was carried out to investigate the effects of exogenous H2S on renal IRI by regulating autophagy in mice.MethodsMice were randomly assigned to control, IRI and NaHS (an H2S donor, 28, 56 and 100 μmol/kg) groups. Renal IRI was induced
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2,5‐Dihydroxyacetophenone attenuates acute kidney injury induced by intra‐abdominal infection in rats Nephrology (IF 2.4) Pub Date : 2024-07-26 Tao Han, Ye Jiang, Weixing Ge, Yuyu Lu, Rongming Liu, Zunpeng Sun
AimsAs one of the most serious complications of sepsis, acute kidney injury (AKI) is pathologically associated with excessive inflammation. 2,5‐Dihydroxyacetophenone (DHAP) is isolated from Radix rehmanniae praeparata and exhibit potent anti‐inflammatory property. This research aimed at determining the role of DHAP in sepsis‐associated AKI (SA‐AKI) and the underlying mechanism.MethodsPlasma creatinine
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Coronavirus disease 2019 vaccination effectiveness based on the 2021 Japanese dialysis registry Nephrology (IF 2.4) Pub Date : 2024-07-18 Yuka Sugawara, Masao Iwagami, Kan Kikuchi, Toyohiro Hashiba, Sayaka Yabushita, Munekazu Ryuzaki, Masaomi Nangaku
AimThe effectiveness of the coronavirus disease (COVID‐19) vaccine in Japanese patients undergoing haemodialysis has previously not been evaluated on a large scale. We analyzed data from the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR), covering nearly all Japanese patients undergoing dialysis (~95% coverage), to examine the association between COVID‐19 vaccination and infection
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Intracardiac vascular access in haemodialysis: A last resort for exhausted traditional access Nephrology (IF 2.4) Pub Date : 2024-07-18 Carlos Narváez Mejía, Arshdeep Singh, Florentino Villanego, Javier Naranjo, Juan Manuel Cazorla Lopez, Tomas Daroca Martínez, Marta Alonso Mozo, Jose Manuel Amaro Martín, Manuel Ceballos, Auxiliadora Mazuecos
Depletion of veins for dialysis access is a challenging life threatening situation for patients in need of haemodialysis. The utilisation of intracardiac catheter is a rare procedure with scarce reported experience. We describe the case of a 68‐year‐old male that contributes to the limited knowledge of performing a life‐saving intracardiac catheter placement for emergency haemodialysis in a patient
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Low dose glucocorticoids, mycophenolate mofetil and hydroxychloroquine in IgA nephropathy, an update of current clinical trials Nephrology (IF 2.4) Pub Date : 2024-07-18 Pei Chen, Jicheng Lv
This mini‐review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP‐IgAN regarding glucocorticoid efficacy, emphasizing reduced‐dose protocols as potentially safer options. MMF's effectiveness varies among populations, demonstrating promise in Chinese cohorts but yielding
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The pathogenesis of IgAN: Where is pathogenic IgA produced? Nephrology (IF 2.4) Pub Date : 2024-07-17 Heather N. Reich, Yuko Makita
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Rhodojaponin VI ameliorates podocyte injury related with MDM2/Notch1 pathway in rat experimental membranous nephropathy Nephrology (IF 2.4) Pub Date : 2024-07-16 Anni Song, Ruiwei Yan, Yue Qiu, Xingjie Yin, Jing Xiong, Guangmin Yao, Chun Zhang
AimRhodojaponin VI (R‐VI) is the key compound of Rhododendron molle G. Don (Ericaceae) (RM) with effective clinical application in rheumatoid arthritis and chronic glomerulonephritis. In our study, we tried to explore the effect of R‐VI on the rat model of membranous nephropathy.MethodsThe rat model of passive heymann nephritis (PHN) was established by injecting sheep anti‐rat Fx1A serum at a single
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Impact of cultural diversity on COVID‐19 vaccination hesitancy in kidney transplant recipients Nephrology (IF 2.4) Pub Date : 2024-07-09 Rachel Frederick, Frank Ierino, Rey Lopez, David Goodman
AimTo study COVID‐19 vaccination status in kidney transplant recipients (KTRs), reasons for incomplete vaccination and the clinical impact of vaccination on patient outcomes.MethodsA single‐centre retrospective analysis of KTR (n = 543) conducted between 1970 and December 2022. Data included baseline demographics, number of vaccinations, reason for incomplete vaccination and patient outcomes following
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Current understanding and new insights in the treatment of IgA nephropathy Nephrology (IF 2.4) Pub Date : 2024-07-03 Yuemiao Zhang, Hong Zhang
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, and almost all patients are at risk of progression to end‐stage kidney disease within their lifetime. The mechanisms responsible for the presentation and development of IgAN are required for the development of highly targeted therapies for this disease. In this review, we first demonstrate the current treatment strategy
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The renal apical sodium‐dependent bile acid transporter expression rescue attenuates renal damage in diabetic nephropathy via farnesoid X receptor activation Nephrology (IF 2.4) Pub Date : 2024-06-27 Youmei Li, Shuguang Pang, Honggang Guo, Shuo Yang
AimBile acids (BA) function as signalling molecules regulating glucose‐lipid homeostasis and energy expenditure. However, the expression of the apical sodium‐dependent bile acid transporter (ASBT) in the kidney, responsible for renal BA reabsorption, is downregulated in patients with diabetic kidney disease (DKD). Using the db/db mouse model of DKD, this study aimed to investigate the effects of rescuing
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Potential kidney protective effects of glucagon‐like peptide‐1 receptor agonists Nephrology (IF 2.4) Pub Date : 2024-06-21 Philippa Trevella, Elif I. Ekinci, Richard J. MacIsaac
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have gained increasing attention for their potential benefits in people with type 2 diabetes (T2DM) with chronic kidney disease (CKD). This class of medication has demonstrated promising results in reducing albuminuria, preserving estimated glomerular filtration rate (eGFR), and mitigating cardiovascular (CV) risk, making them potential therapeutic
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The significance of serum SLC7A11 levels in the occurrence of vascular calcification in maintenance peritoneal dialysis patients. Nephrology (IF 2.4) Pub Date : 2024-06-12 Jing Wu,Junling Zhang,Qiong Tang,Huixian Zhu,Yan Chen,Hua Xiong,Hongwei Jiang
AIM This research aimed to explore the serum levels of solute carrier family 7 member 11 (SLC7A11) in patients with maintenance peritoneal dialysis (MPD) and its correlation with vascular calcification (VC) and clinical results. METHODS This present prospective observational cohort study enrolled 189 patients with MPD who were undergoing regular peritoneal dialysis for over 3 months in our hospital
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Associations between bioelectrical impedance analysis-derived phase angle, protein-energy wasting and all-cause mortality in older patients undergoing haemodialysis. Nephrology (IF 2.4) Pub Date : 2024-06-10 Sho Kojima,Naoto Usui,Akimi Uehata,Akihito Inatsu,Atsuhiro Tsubaki
AIM Protein-energy wasting (PEW) is a common syndrome in patients undergoing haemodialysis (HD) and is associated with poor prognosis. Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is useful for predicting PEW, but sex and age need to be considered. We aimed to reveal sex-specific cut-off values of PA predicting PEW in HD patients aged ≥65. METHODS This two-centre retrospective cohort
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Complicated obstructive uropathy after kidney biopsy: A case report highlighting the risk of biopsy-related acute kidney injury in a patient with unilateral kidney hypoplasia. Nephrology (IF 2.4) Pub Date : 2024-06-09 Chi-Huan Tsai,Yu-Shuo Tang,Chung-Yi Cheng,Wei-Tse Hong
Unilateral kidney hypoplasia is a congenital condition characterized by the underdevelopment of one kidney. Although often asymptomatic, it can cause severe renal complications in patients combined with contralateral renal injury, leading to acute renal failure. This case report describes a patient with unilateral kidney hypoplasia who underwent a kidney biopsy on the contralateral normal-sized kidney
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Glomerular basement membrane ultrastructural changes in a patient with COQ2 glomerulopathy: A case report. Nephrology (IF 2.4) Pub Date : 2024-06-04 Liuyu Sun,Yali Ren,Baige Su,Suxia Wang,Xuhui Zhong,Yuwu Jiang,Fang Wang
Primary coenzyme Q10 deficiency-1, caused by COQ2 disease-causing variants, is an autosomal recessive disorder, and genetic testing is the gold standard for diagnosing this condition. A Chinese boy with steroid-resistant nephrotic syndrome, focal segmental glomerulosclerosis, and progressive kidney insufficiency was included in the study. Electron microscopy revealed the glomerular basement membrane
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Rehmapicrogenin attenuates lipopolysaccharide-induced podocyte injury and kidney dysfunctions by regulating nuclear factor E2-related factor 2/antioxidant response element signalling. Nephrology (IF 2.4) Pub Date : 2024-06-04 Xiaohong Ma,Guandong Li,Yufeng Shi,Zhitao Shang
BACKGROUND Apoptosis and oxidative stress in kidneys are critical players in acute kidney injury (AKI). Rehmapicrogenin, a monomeric compound extracted from Rehmanniae radix, has been found to possess nitric oxide inhibitory and anti-inflammatory activities. Thus, this study aimed to investigate the roles and mechanisms of rehmapicrogenin in AKI. METHODS Lipopolysaccharide (LPS) was used to induce
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Early experience of using regional citrate anticoagulation for continuous renal replacement therapy in critically ill patients in a resource-limited setting. Nephrology (IF 2.4) Pub Date : 2024-06-03 M Shahnaz Hasan,Muhammad Afif Jamaludin,Sarah Aliah Mohd Azman,Rafidah Atan,Mei Hoon Yap,Zheng-Yii Lee,Nor'azim Mohd Yunos
AIM Despite the superiority of regional citrate anticoagulation (RCA) in continuous renal replacement therapy (CRRT), its application is limited in resource-limited settings. We aim to explore the cost and safety of RCA for CRRT in critically ill patients, compared to usual care. METHODS This prospective observational study included patients requiring CRRT in a tertiary intensive care unit (ICU) from
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Obinutuzumab in untreated primary membranous nephropathy: An observational case series. Nephrology (IF 2.4) Pub Date : 2024-06-03 Jinling Hao,Jing Wang,Pan Zhou,Rong Xu,Xiaoli Chen
BACKGROUND As an initial treatment for primary membranous nephropathy (PMN), there remains a significant proportion of patients for whom rituximab is not fully effective. Here, we aimed to assess the effectiveness and safety of obinutuzumab as initial treatment in patients with PMN. METHODS In this observational case series, patients diagnosed with PMN and treated with obinutuzumab as initial treatment
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The EKFC equation outperforms the CKD‐EPI and CKiD equations for GFR estimation in adolescent and young adult kidney transplant patients Nephrology (IF 2.4) Pub Date : 2024-05-28 Chloé Grosyeux, Asma Alla, Françoise Barbé, Laurence Derain Dubourg, Laurence Chardon, Jean‐Louis Guéant, Luc Frimat, Abderrahim Oussalah, Isabelle Vrillon
AimThis study evaluated the bias and accuracy of the CKD‐EPI/CKiD and EKFC equations compared with the reference exogenous tracer‐based assessment of glomerular filtration rate (GFR) in adult and pediatric patients according to their renal transplant status.MethodsWe assessed the bias and P30 accuracy of the CKD‐EPI/CKiD and EKFC equations compared with iohexol‐based GFR measurement.ResultsIn the overall
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Multiple myeloma complicated with light chain cast nephropathy with focal amyloidosis: A case report Nephrology (IF 2.4) Pub Date : 2024-05-14 Yicao He, Zhijuan Hua, Hu Tan, Congjuan Zhao, Qiang Liu, Juan Jia, Yan Gao
This case report describes a rare and interesting case of a patient with multiple myeloma complicated with light chain (LC) cast nephropathy and focal amyloidosis. The patient presented with acute kidney injury, anaemia and bone lesions. The diagnosis was confirmed by bone marrow biopsy, serum and urine electrophoresis and kidney biopsy. The patient was treated with isazomil, pomalidomide and dexamethasone
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RUNX3 alleviates mitochondrial dysfunction and tubular damage by inhibiting TLR4/NF‐κB signalling pathway in diabetic kidney disease Nephrology (IF 2.4) Pub Date : 2024-05-13 Ling Xiao, Gang Ye
AimThe impaired function of tubular mitochondria is critical in diabetic kidney disease (DKD) progression. RUNX3 is down‐regulated in DKD models. We intend to explore the effects of RUNX3 on mitochondrial dysfunction and renal tubule injury in DKD and related mechanisms.MethodsThe development of diabetes models involved injecting mice with streptozotocin while treating HK‐2 cells with high glucose
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Renal thrombotic microangiopathy is associated with poor renal survival in children with immunoglobulin A nephropathy Nephrology (IF 2.4) Pub Date : 2024-05-08 Meng Yang, Le Wang, Xiong‐Fei Sun, Dong‐Qi Yin
AimThe aim of this study was to examine the clinical and pathological characteristics as well as the prognosis of immunoglobulin A nephropathy (IgAN) accompanied by renal thrombotic microangiopathy (rTMA) in paediatric patients.MethodsAfter balancing epidemiological characteristics and pathological types between groups, 427 patients (rTMA group: 23, non‐rTMA group: 46) were included. The clinical and
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Nephrology referral slows the progression of chronic kidney disease, especially among patients with anaemia, diabetes mellitus, or hypoalbuminemia: A single‐centre, retrospective cohort study Nephrology (IF 2.4) Pub Date : 2024-05-02 Atsuki Ide, Keisuke Ota, Miho Murashima, Kodai Suzuki, Takahisa Kasugai, Yuki Miyaguchi, Tatsuya Tomonari, Minamo Ono, Masashi Mizuno, Maki Hiratsuka, Takeshi Kawai, Takashi Suzuki, Kazutaka Murakami, Takayuki Hamano
BackgroundThe Kidney Disease Improving Global Outcomes guidelines recommend nephrology referral for patients with chronic kidney disease (CKD) stages 4 to 5, significant proteinuria and persistent microscopic haematuria. However, the recommendations are opinion‐based and which patients with CKD benefit more from nephrology referral has not been elucidated.MethodsIn this retrospective cohort study,