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Barriers and facilitators to application of treat-to-target management in psoriatic arthritis and axial spondyloarthritis in practice: A systematic literature review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-09-07 Casper Webers, Ivette Essers, Marin Been, Astrid van Tubergen
To review the evidence on barriers and facilitators to application of treat-to-target (T2T) in axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) in daily practice. A systematic search was conducted in MEDLINE/Embase up to December 2023, focusing on axSpA/PsA. Any type of quantitative/qualitative original research was eligible for inclusion if barriers or facilitators to application of T2T
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Validation of the ankle-specific pediatric arthritis ultrasound scoring system in children with juvenile idiopathic arthritis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-09-01 Patricia Vega-Fernandez, Kelly Rogers, Pinar Ozge Avar-Aydin, Megan Quinlan-Waters, Jennifer Huggins, Hermine I Brunner, Daniel J. Lovell, Mekibib Altaye, Amy Cassedy, Arthur B Meyers, Tracy V Ting
To validate the ankle-specific Pediatric Arthritis Ultrasound Scoring System (PAUSS-ankle) in children with juvenile idiopathic arthritis (JIA). Patients with a diagnosis of JIA prospectively underwent a standard clinical assessment and musculoskeletal ultrasound (MSUS) of one or both ankles. B-mode and Power-Doppler mode MSUS images were acquired and scored according to the PAUSS-ankle protocol. A
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Performance of cut-offs of the ASAS Health Index to discriminate between treatment groups in patients with axial spondyloarthritis in the TICOSPA trial Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-30 U Kiltz, A Molto, C Lopez-Medina, M Dougados, D van der Heijde, A Boonen, F Van den Bosch, J Braun
To test trial and longitudinal known group discrimination of thresholds of meaning for improvement and health states of the ASAS Health Index (ASAS HI) in patients with active axSpA treated in a randomized study. Data from baseline and week 48 from the tight-controlled, treat-to-target trial TICOSPA study were used. The performance of different thresholds to assess change or health states of the ASAS
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The association between cam morphology and hip pain in males and females within 10 years: A national prospective cohort study (CHECK) Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-23 Jinchi Tang, Michiel M.A. van Buuren, Fleur Boel, Noortje S. Riedstra, Myrthe A. van den Berg, Jos Runhaar, Sita Bierma-Zeinstra, Rintje Agricola
To determine the association between baseline cam morphology and self-reported hip pain assessed at annual visits over a 10-year follow-up period stratified by biological sex. The secondary aim was to study the association between the magnitude of cam morphology and the severity of pain in symptomatic hips. The nationwide prospective Cohort Hip and Cohort Knee (CHECK) study includes 1,002 participants
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Letter to the editor to 'Soluble CXCL16 is a prognostic biomarker associated with rapidly progressive interstitial lung disease complicated with dermatomyositis' Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-23 Jie Gao, Yu Wang
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Macrophages–Autoimmunity–Treatment option Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-22 Rainer Ebid
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Response to the letter entitled " Letter to the editor to Soluble CXCL16 is a prognostic biomarker associated with rapidly progressive interstitial lung disease complicated with dermatomyositis" by Gao et al. Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-22 Changhong Li, Hua Zhang, Jinxia Zhao
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Initiation of glucocorticoids before entering rheumatology care associates with long-term glucocorticoid use in older adults with early rheumatoid arthritis: A joint analysis of Medicare and the Rheumatology Informatics System for Effectiveness (RISE) data Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-22 Andriko Palmowski, Eric T Roberts, Jing Li, Emma Kersey, Rachael Stovall, Frank Buttgereit, Jinoos Yazdany, Gabriela Schmajuk
To assess relationships between the timing of glucocorticoid (GC) initiation, entrance into rheumatology care, and the duration of GC use in older adults with early rheumatoid arthritis (eRA) in the U.S. Data from the Rheumatology Informatics System for Effectiveness (RISE) registry and Medicare (2016–2018) were linked. Patients with ≥2 RA ICD codes in RISE were included; the first being the index
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The control group matters: Pain, physical function and strength improvements relative to the comparator intervention in knee and hip osteoarthritis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-16 Kendal A. Marriott, Michelle Hall, Jacquelyn M. Maciukiewicz, Rachel D. Almaw, Emily G. Wiebenga, Natasha K. Ivanochko, Daniel Rinaldi, Emma V. Tung, Kim L. Bennell, Monica R. Maly
In knee and hip osteoarthritis (OA), the mechanism for resistance exercise improving clinical outcomes and the dose-response between strength and clinical outcomes are unknown; in part due to inconsistent trial designs across studies. To determine whether the effects of resistance exercise interventions on pain and function differ based on comparator group; and whether there is an association between
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Comparison of a handheld ultrasound device with cart-based ultrasound for the assessment of gout lesions in people with established gout Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-15 Rachel Murdoch, Lene Terslev, Julia Martin, Borislav Mihov, Gregory D Gamble, Søren Torp-Pedersen, Anne M Horne, Nicola Dalbeth
Use of handheld portable ultrasound is increasing and would improve access for people with rheumatic disease when conventional, cart-based ultrasound is unavailable. This study compared handheld and cart-based ultrasound for the assessment of gout lesions in people with gout. The lower limbs of 21 participants with gout were independently scanned at six sites (1st and 2nd metatarsophalangeal joints
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Clinical characteristics of idiopathic inflammatory myopathies patients with anti-PM/Scl antibodies Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-10 Longyang Zhu, Chen Zong, Yiran Chen, Guochun Wang, Yongpeng Ge
To analyze the clinical features of idiopathic inflammatory myopathies (IIMs) patients with anti-PM/Scl antibodies. In this retrospective cohort study, we compared the clinical manifestations between patients who were solely positive for anti-PM/Scl antibodies (isolated anti-PM/Scl group) and those with a coexistence of anti-PM/Scl antibodies and myositis-specific antibodies (MSAs) (double-positive
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Construct validity of PROMIS pain interference, fatigue, and physical function as patient-reported outcomes in adults with idiopathic inflammatory myopathies: An international study from the OMERACT myositis working group Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-10 Ellen Romich, Didem Saygin, Dana DiRenzo, Christopher A. Mecoli, Ingrid de Groot, Karin Lodin, Malin Regardt, Catherine Sarver, Ju Yeon Kim, Jin Kyun Park, Kelly Beer, Merrilee Needham, Helene Alexanderson, Lisa Christopher-Stine, Marianne de Visser, Joost Raaphorst, OMERACT Myositis Working Group
Validated patient-reported outcome measures to assess disease impact in patients with adult idiopathic inflammatory myopathies (IIMs) are needed. The objective of this study was to assess the construct validity of PROMIS Pain Interference, Fatigue, and Physical Function measures in comparison with core disease activity measures. Adults with IIM, excluding inclusion body myositis, from OMERACT Myositis
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Clinical stratification of 1318 Primary Sjögren's Syndrome patients Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-10 Jinxia Fang, Jiajia Wang, Jing Luo, Ping Wang, Jin Zhang, Dan Chen, Wenjing Ye, Yi Zhang, Shaobiao Pan, Xiaobing Wang
Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by diverse clinical manifestations yet lacking effective therapeutic strategies currently. This study aims to gain a thorough understanding of the clinical landscape of pSS and further delineate its clinical subtypes, thereby enabling the efficient management for pSS. We conducted a cross-sectional observational study of
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Bone and entheseal targets for growth factors in diffuse idiopathic skeletal hyperostosis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-10 Geoffrey Owen Littlejohn
Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition of the adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for the new bone growth is unclear but many lines of evidence point to a role for growth factors linked to abnormal metabolism in these patients. The bone targets for these presumed growth factors are poorly defined. This review summarises
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Interplay between polygenic risk score and solar insolation: Implication for systemic lupus erythematosus diagnosis and pathogenesis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-10 I-Chieh Chen, Ta-Chien Chan, Hui-Wen Yang, Yen-Ju Chen, Yi-Ming Chen
This research elucidates the correlation between solar radiation insolation, polygenic risk score (PRS), and systemic lupus erythematosus (SLE) diagnosis, utilizing genomic, environmental, and clinical data. We included 1,800 SLE participants and 1,800 controls from the Taiwan Precision Medicine Initiative, genotyped via the Affymetrix Genome-Wide TWB 2.0 SNP Array. The study employed a SLE-PRS tailored
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Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-08 Fabricio Espinosa-Ortega, Karin Lodin, Maryam Dastmalchi, Jiri Vencovsky, Louise P Diederichsen, Samuel Katsuyuki Shinjo, Maria Giovanna Danieli, Albert Selva-O'Callaghan, Marianne de Visser, Zoltan Griger, Angela Ceribelli, Diana Gómez-Martin, Helena Andersson, Mónica Vázquez-Del Mercado, Hector Chinoy, James B Lilleker, Paul New, Niels S Krogh, Ingrid E Lundberg, Helene Alexanderson, MYONET Registry
To study the trajectories of changes in damage over time and explore associations with autoantibody defined subgroups using a large international cohort of patients with idiopathic inflammatory myopathies (IIM). Data from the MYONET registry, including patients who were tested for autoantibodies and had at least one assessment of damage using the Myositis Damage Index (MDI), were analyzed. Patients
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Differences in the autoantibody phenotypes and long-term outcomes between juvenile- and adult-idiopathic inflammatory myopathies Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-08 Hideaki Tsuji, Ran Nakashima, Takahiro Yasumi, Tsuneo Sasai, Yuki Ichimura, Mirei Shirakashi, Hideo Onizawa, Ryosuke Hiwa, Koji Kitagori, Shuji Akizuki, Akira Onishi, Hajime Yoshifuji, Masao Tanaka, Naoko Okiyama, Tsuneyo Mimori, Akio Morinobu
To investigate differences in autoantibodies, clinical features, and long-term outcomes between juvenile-idiopathic inflammatory myopathy (IIM) and adult-IIM Autoantibodies, clinical characteristics, and drug-free conditions for a maximum of 20 years were retrospectively analyzed in 320 Japanese IIM patients (juvenile-IIM, = 34; adult-IIM, = 286) using the Kyoto University Registry. Autoantibodies
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Large-vessel imaging in patients with giant cell arteritis with scalp involvement: A commentary on giant cell arteritis associated with scalp, tongue or lip necrosis in a French multi-center case control study Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-06 Daniel Montes, Nicholas E. Bohrer, Kenneth J. Warrington, Matthew J. Koster
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Minimally invasive interventional procedures for osteoarthritis and inflammatory arthritis: A systematic review and meta-analysis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-05 Jacopo Ciaffi, Nicolas Papalexis, Elena Vanni, Marco Miceli, Cesare Faldini, Lorenza Scotti, Antonella Zambon, Carlo Salvarani, Roberto Caporali, Giancarlo Facchini, Francesco Ursini
to summarize the evidence on the efficacy of minimally invasive interventional procedures such as radiofrequency ablation (RFA) and transcatheter arterial embolization (TAE) in patients with osteoarthritis or inflammatory arthritis. a literature search was conducted in PubMed and Web of Science databases. Both randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSI) were
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The immune pathology of bursitis in rheumatic inflammatory diseases, degenerative conditions and mechanical stress: A systematic review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-03 Anqi Zhang, Elisabeth Brouwer, Maria Sandovici, Arjan Diepstra, William F. Jiemy, Kornelis S.M. van der Geest
To summarize current insights on the immune pathology of bursitis caused by rheumatic inflammatory diseases, degenerative conditions, or mechanical stress and identify knowledge gaps in this field. Data on tenosynovitis pathology was included for comparison. We performed a systematic review encompassing an electronic database search of all published literatures in PubMed/MEDLINE from inception to February
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“It means almost forgetting that you've got a disease”: An OMERACT study to define independence in the context of rheumatoid arthritis remission from the patient perspective Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-08-03 Caroline A. Flurey, Bethan Jones, Ummugulsum Gazel, Chikosolu Uzoka, Kate Rosser, Thomas Khoo, Marieke Voshaar, Wijnanda Hoogland, Beverley Shea, Lynn March, Dorcas Beaton, Peter Tugwell, Susanna Proudman, OMERACT remission in RA: Patient perspective working group
Our previous work identified pain, fatigue, and independence as missing from the ACR/EULAR rheumatoid arthritis (RA) remission criteria from the patient perspective. Validated measures exist for pain and fatigue, but not for independence. As a first step towards developing such a measure, this study aimed to understand ‘Independence’ in the context of RA remission from the patient perspective. International
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Analysis of synovitis patterns in early RA supports the importance of joint-specific factors Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-31 Laura Bricman, Clément Triaille, Emilie Sapart, Tatiana Sokolova, Aleksandra Avramovska, Francesco Natalucci, Thomas Kirchgesner, Patrick Durez
Rheumatoid arthritis (RA) is classically considered a systemic disorder, but the role of local factors in driving synovial inflammation is increasingly being recognized. These joint-specific factors may consequently modulate disease phenotype. Our goal was to study the spatial distribution of swelling, tenderness and erosions in a large cohort of early RA (ERA) patients, to assess for patterns of
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Serum uric acid, a potential biomarker for interstitial lung disease in anti-MDA5 antibody-positive dermatomyositis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-27 Huaiya Xie, Junping Fan
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OMERACT systemic lupus erythematosus domain survey Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-24 Wils Nielsen, Vibeke Strand, Lee Simon, Ellie Pinsker, Dennisse Bonilla, Eric Morand, Julian Thumboo, Martin Aringer, Marta Mosca, Ian Bruce, Ioannis Parodis, Alfred Kim, Maya Desai, Yvonne Enman, Beverley Shea, Daniel J. Wallace, Yashaar Chaichian, Sandra Navarra, Cynthia Aranow, Meggan Mackay, Kimberly Trotter, Oshrat E. Tayer-Shifman, Alí Duarte-García, Lai Shan Tam, Manuel F. Ugarte-Gil, Guillermo
Since the development of the OMERACT Systemic Lupus Erythematosus (SLE) Core Outcome Set (COS) in 1998, many new SLE domains have been identified and measures developed, creating a need to update the SLE COS. To revisit the 1998 SLE COS and research agenda domains, and generate new candidate domains, we conducted this study of patients with SLE and collaborators. (1) To evaluate existing candidate
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Machine learning in the prediction of treatment response in rheumatoid arthritis: A systematic review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-23 Claudia Mendoza-Pinto, Marcial Sánchez-Tecuatl, Roberto Berra-Romani, Iván Daniel Maya-Castro, Ivet Etchegaray-Morales, Pamela Munguía-Realpozo, Maura Cárdenas-García, Francisco Javier Arellano-Avendaño, Mario García-Carrasco
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Clinically relevant differences between primary Raynaud's phenomenon and secondary to connective tissue disease Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-18 Stefano Di Donato, Suiyuan Huang, John D Pauling, Francesco Del Galdo, Maya Sabbagh, Dinesh Khanna, Michael Hughes
Raynaud's phenomenon (RP) is a symptom complex associated with digital vascular compromise. Our aim was to examine for clinically relevant differences between primary RP (PRP) and secondary RP (SRP) to connective tissue disease. We report cross-sectional results from the Patient Survey of experiences of Raynaud's Phenomenon (PASRAP), which aimed to explore the broad-ranging impact of RP. The survey
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Subcutaneous vs intravenous abatacept in rheumatoid arthritis-interstitial lung disease. National multicentre study of 397 patients Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-18 Marta López-Maraver, Ana Serrano-Combarro, Belén Atienza-Mateo, Natividad del Val, Ivette Casafont-Solé, Rafael B. Melero-Gonzalez, Alba Pérez-Linaza, Jerusalem Calvo Gutiérrez, Natalia Mena-Vázquez, Nuria Vegas-Revenga, Lucía Domínguez-Casas, Jesús Loarce Martos, Cilia Amparo Peralta Ginés, Carolina Diez Morrondo, Lorena Pérez Albaladejo, Rubén López Sánchez, Mª Guadalupe Manzano Canabal, Anahy Mª
Evidence on abatacept (ABA) utility for rheumatoid arthritis (RA) – associated interstitial lung disease (ILD) is growing. Clinical trials have shown equivalence in subcutaneous (SC) and intravenous (IV) administration of ABA for articular manifestations. However, this has not been studied in respiratory outcomes. To compare the effectiveness of ABA in RA-ILD patients according to the route of administration
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Muscle biopsy practices in the evaluation of idiopathic inflammatory myopathies: An international survey of expert clinicians Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-15 Samuel Maxwell, Laura Ross, Shereen Oon, Ian P. Wicks, Jessica Day
Muscle biopsy is an important test in the evaluation of individuals with suspected myopathy, including those with suspected idiopathic inflammatory myopathy (IIM). Various approaches, including open surgical biopsy, needle biopsy and conchotome forceps, have been reported. However the real-world utilisation of these approaches remains unclear. There are no established guidelines for the use of muscle
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Real-world application of the pediatric Glucocorticoid Toxicity Index in childhood-onset lupus Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-15 Emily Zhang, Sarah Capponi, Rebecca Scobell, Gabrielle Alonzi, Madeline Hlobik, Ankana Daga, Esra Meidan, Holly Wobma, Liyoung Kim, Lauren A. Henderson, Siobhan Case, Peter A. Nigrovic, John H. Stone, Karen H. Costenbader, Mary Beth F. Son, Joyce C. Chang
The pediatric Glucocorticoid Toxicity Index (pGTI) is a new, pediatric-specific tool to quantify glucocorticoid (GC)-related morbidity in children. We evaluated the feasibility and construct validity of retrospective pGTI scoring in patients with pediatric-onset systemic lupus erythematosus (pSLE) and identified risk factors for cumulative toxicity. We conducted a retrospective cohort study of patients
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Risk of incident gout following exposure to recombinant zoster vaccine in US adults aged ≥65 years Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-15 Chengchen Zhang, Alejandro Amill-Rosario, Abree Johnson, Haeyoung Lee, O'Mareen Spence, Driss Oraichi, Harry Seifert, Valentine Franck, Susan Gamble, Huifeng Yun, Susan dosReis
Assess the risk of incident gout following exposure to recombinant zoster vaccine (RZV). This case-only, self-controlled risk interval study included a cohort of US fee-for-service Medicare (Part A, B, and D) beneficiaries aged ≥65 years. The exposure was receipt of at least one dose of the two-dose RZV regimen in 2018 or 2019. The risk and control windows were days 1–30 and days 31–60, respectively
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Anti-HMGCR myopathy: Diversity of clinical presentations in a national cohort in New Zealand Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-14 Ke Li Chow, Paula Elizabeth Keating, Kamal Solanki, Mark Sapsford, Karen Lindsay, John Liston O'Donnell
We describe the varied clinical presentations, barriers in diagnosis and outcomes of anti-HMGCR myopathy in a large national cohort. Adults found positive for serum anti-HMGCR autoantibodies via line blot or enzyme-immunoassay followed by immunoprecipitation were included in the study. Of 75 patients identified, the records of 72 (96 %) described weakness as the presenting symptom. The records of 65
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Risk of incident gout following exposure to recombinant zoster vaccine in US adults aged ≥50 years Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-14 Sheryl A. Kluberg, Andrew L. Simon, Sarah M. Alam, Alexander Peters, Casie Horgan, Dongdong Li, Erick Moyneur, Elizabeth Messenger-Jones, Richard Platt, Cheryl N. McMahill-Walraven, Djeneba Audrey Djibo, Kimberly Daniels, Aziza Jamal-Allial, Claire H. Pernar, Najat J. Ziyadeh, Qianli Ma, Mano Selvan, O'Mareen Spence, Driss Oraichi, Harry Seifert, Valentine Franck, Susan Gamble, Huifeng Yun
To assess whether recombinant zoster vaccine (RZV) is associated with an increased risk of new-onset gout among US adults aged ≥50 years. We conducted a real-world, retrospective safety study with a self-controlled risk interval (SCRI) design using administrative claims data. We included health plan members aged ≥50 years with RZV exposure, followed by incident gout within 60 days. Days 1−30 following
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Improvement of bone mineral density and new vertebral fractures during 8 years of TNF-α inhibition in patients with axial spondyloarthritis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-11 Mark Siderius, Freke Wink, Stan Kieskamp, Fiona Maas, Reinhard Bos, Frans G.M. Kroese, Anneke Spoorenberg, Suzanne Arends
In our prospective cohort with standardized bi-annual measurements of bone mineral density (BMD) and spinal radiographs, we evaluated the long-term course of BMD and the development of radiographic vertebral fractures (VFs) during 8 years of TNFi treatment in patients with radiographic axial spondyloarthritis (r-axSpA). Consecutive axSpA patients from the GLAS cohort receiving TNFi for ≥8 years were
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Commentary on IgG4-related uveitis. A French cohort and literature review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-07 Mustafa Ekici, Sibel Kadayıfçılar, Figen Bezci, Ömer Karadağ
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Response to commentary on IgG4-related uveitis. A French cohort and literature review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-06 Emily Stuchfield-Denby, Benjamin De Sainte Marie, Nicolas Schleinitz
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Taper versus discontinuation of tocilizumab in patients with giant cell arteritis: Real-world experience from a tertiary center Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-04 Marc K. Nielsen, Andreas W. Nielsen, Agnete O. Donskov, Ib T. Hansen, Berit D. Nielsen, Christoffer Mørk, Ellen M. Hauge, Kresten K. Keller
Following the approval of tocilizumab (TCZ) for giant cell arteritis (GCA), recent studies have shown a high relapse frequency after abrupt discontinuation of TCZ. However, a thorough exploration of TCZ tapering compared to abrupt discontinuation has never been undertaken. Likewise, adverse events have only been scarcely investigated in routine care. This study aimed to compare the incidence of relapses
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Whole phenotype of patients with systemic sclerosis and sicca manifestations: Comparison with sicca manifestations from other causes Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-04 François Zimmermann, François Robin, Elisabeth Diot, Aurore Bleuzen, Sandrine Jousse-Joulin, Claire de Moreuil, Nicolas Belhomme, Claire Cazalets, Ronan Garlantézec, Agnès Gazzola, Francisco Llamas-Gutierrez, Romain Muraz, Antoinette Perlat, Guillaume Coiffier, Alain Lescoat
This study aimed to characterize the whole phenotype of Systemic sclerosis (SSc) patients with sicca symptoms, using major salivary glands Ultrasound (SGUS) parameters, minor salivary glands biopsies (mSGB) and clinical findings, and to compare these characteristics with those from patients with Sjogren's Disease (SjD), and patients with sicca manifestations from other causes. Sixty SSc patients fulfilling
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Prognostic factors and the value of radiographic osteoarthritis for persistent complaints after referral for ankle radiography Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-03 S.E.(Sabine) Kloprogge, R.M.M.(Roshni) Lachmipersad, N.(Nienke) Katier, A.K.E.(Adinda) Mailuhu, J.(Jeanette) van Vooren, J.M.(John) van Ochten, P.J.E.(Patrick) Bindels, S.M.A.(Sita) Bierma-Zeinstra, M.(Marienke) van Middelkoop
Ankle symptoms are a common reason to consult the general practitioner and often persist for years. In a population referred for ankle radiography, the prevalence of radiographic osteoarthritis (OA) is substantial, but its additional predictive value for persistent symptoms is unknown. Therefore, we examined the prognosis of symptoms 2–3 years after referral for ankle radiography, assessed clinical
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Mortality risk in patients with anti-MDA5 antibody-positive dermatomyositis: A risk assessment Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-03 Tomoyuki Kawada
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Modelling long-term outcomes for patients with systemic lupus erythematosus Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-02 Z. Touma, S. Kayaniyil, A. Parackal, D. Bonilla, J. Su, A. Johnston, J. Gahn, E.D. Hille, R. Ohsfeldt, S. Chandran
New treatments for systemic lupus erythematosus (SLE) aim to improve tolerability and disease activity control over standard of care (SoC) treatment. SoC typically includes daily glucocorticoid (GC) which carries a risk of organ damage over time. This study sought to develop natural history models to identify predictors of long-term outcomes with current SoC SLE treatment. Generalized linear and parametric
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Brain white matter microstructural alterations in Behcet's syndrome correlate with cognitive impairment and disease severity: A diffusion tensor imaging study Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-02 Osman Aykan Kargin, Serdar Arslan, Bora Korkmazer, Sabriye Guner, Ayse Ozdede, Nursena Erener, Elif Burcu Ersungur Celik, Gulcin Baktiroglu, Rauf Hamid, Ahmet Oz, Burc Cagri Poyraz, Ugur Uygunoglu, Emire Seyahi, Osman Kizilkilic
To evaluate the microstructural integrity of brain white matter tracts in patients with Neuro-Behcet's syndrome (NBS) and Behcet's syndrome (BS) without neurological manifestations using diffusion tensor imaging (DTI) and to investigate potential utility of DTI as a surrogate biomarker of neurocognitive functioning and disease severity. This cross-sectional study comprised 34 NBS patients and 32 BS
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TNFRSF11A variants contribute to systemic autoinflammatory diseases: A case series of 12 patients Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-02 Vasileios Papatheodorou, Charalampos Gerodimos, Antonios Dimitrakopoulos, Efrosini Lada, Maria G Tektonidou, Anastasios Germenis, Petros P Sfikakis, Katerina Laskari
Limited evidence suggests that variants in gene, encoding RANK, may contribute to systemic autoinflammatory disease (SAID). To estimate the prevalence of variants in a cohort of patients with SAIDs screened for 26 related genes and describe the disease phenotypic expression. A total of 12 out of 167 patients, 7 males, aged (median) 38 years at disease onset, yielded at least one rare variant. All patients
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Corrigendum to “The Glucocorticoid Toxicity Index: Measuring Change in Glucocorticoid Toxicity Over Time” [Seminars in Arthritis and Rheumatism 55 (2022):152010] Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-07-02 John H. Stone, P. Jane McDowell, David R.W. Jayne, Peter A. Merkel, Joanna Robson, Naomi J. Patel, Yuqing Zhang, Huibin Yue, Pirow Bekker, Liam G. Heaney
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Advancing composite outcome measures: Insights on weighting components from OMERACT 2023 Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-30 George A Wells, Francis Guillemin, Peter A. Merkel, Maarten de Wit, Sarah Mackie, Lyn March, Gunnar Tómasson, Lauren K. King, Sam Michel Cembalo, Shawna Grosskleg, Lara J. Maxwell, Sara Monti, Kaitlin A. Quinn, Beverley J Shea, Peter Tugwell, Dorcas Beaton
The OMERACT Composite Working Group hosted a workshop at OMERACT 2023 to explore the complexities of weighting components in the development of composite outcomes. This study presents the methodology and findings of this workshop, exploring the complexities of weighting the individual components of composite outcome measures. The workshop featured a multifaceted program, beginning with a plenary session
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Effect of biologic agents and inflammation on lipid levels and cardiovascular risk in rheumatoid arthritis patients Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-29 Dimitrios A Pappas, George Reed, Kevin Kane, Jeffrey R Curtis, Christina Charles-Schoeman, Jon T Giles, Joel M Kremer
Cardiovascular disease (CVD) is the main cause of mortality in Rheumatoid Arthritis (RA). To investigate the effect of biologic disease modifying anti-rheumatic drugs (bDMARDs) on lipids and CVD risk and evaluate associations with changes in systemic inflammation. Patients with RA initiating a bDMARD were evaluated at baseline, 3 and 6 months later. Longitudinal mixed effects models examined the association
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Primary central nervous system vasculitis with intracranial aneurysm Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-29 Carlo Salvarani, Robert D. Brown Jr, Teresa J.H. Christianson, John Huston III, Caterina Giannini, Gene G. Hunder
Unruptured intracranial aneurysms (UIAs) are rarely reported in primary central nervous system vasculitis (PCNSV). In this study we described the clinical findings, response to therapy, and outcomes of UIA in a large cohort of PCNSV patients. We retrospectively studied 216 consecutive patients with PCNSV, selected by predetermined diagnostic criteria, who were seen during a 40-year period. UIAs were
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Efficacy and safety of culture-expanded mesenchymal stromal cell therapy in the treatment of 4 types of inflammatory arthritis: A systematic review and meta-analysis of 36 randomized controlled trials Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-29 Liuting Zeng, Kailin Yang, Ganpeng Yu, Junpeng Chen, Zhiyong Long, Wang Xiang, Shuman Liu, Yaru Zheng, Yexing Yan, Moujia Hao, Lingyun Sun
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Ultrasound evaluation contrasts clinical disease activity evaluation in rheumatoid arthritis patients with concomitant anxiety or depression Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-28 Brigitte Michelsen, Joseph Sexton, Tore K Kvien, Sella Aarestad Provan, Hilde Berner Hammer
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Polymyalgia rheumatica is a risk factor for more recalcitrant disease in giant cell arteritis: A retrospective cohort study Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-28 Lien Moreel, Albrecht Betrains, Lennert Boeckxstaens, Geert Molenberghs, Koen Van Laere, Ellen De Langhe, Steven Vanderschueren, Daniel Blockmans
To evaluate differences in presentation and outcome of giant cell arteritis (GCA) patients with and without polymyalgia rheumatica (PMR) symptoms. Consecutive patients diagnosed with GCA between 2000 and 2020 and followed for ≥12 months at the University Hospitals Leuven (Belgium), were included retrospectively. We included 398 GCA patients, of which 181 (45%) with PMR symptoms. Patients with PMR symptoms
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Efficacy and safety of pharmacological treatments for autoimmune disease-associated interstitial lung disease: A systematic review and network meta-analysis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-27 Chenghua Weng, Yiqun Zhou, Lei Zhang, Gang Wang, Zongnan Ding, Leixi Xue, Zhichun Liu
Immunosuppressants, biologic agents, antifibrotic drugs, and other drugs can be used to treat autoimmune disease-associated interstitial lung disease (ILD), but the preferred treatment is uncertain. We aimed to evaluate the efficacy and safety of multiple drugs in the treatment of autoimmune disease-associated ILD. PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and ClinicalTrials
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Risk and predictors of fractures in early rheumatoid arthritis – A long term follow up study of an inception cohort Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-27 Lisa Theander, Ankita Sharma, Magnus K. Karlsson, Kristina E. Åkesson, Lennart T.H. Jacobsson, Carl Turesson
To examine the risk of fractures in a cohort of patients with newly diagnosed rheumatoid arthritis (RA), compared to the background population, and predictors of fractures detectable early in RA. An inception cohort of patients with RA ( = 233; 164 women/69 men, recruited 1995–2005) was evaluated according to a structured program, including repeated clinical assessments and measures of bone mineral
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Corrigendum to “Patient research partner engagement in OMERACT: Enhancing engagement through the implementation of patient engagement in research tools” [Seminars in Arthritis and Rheumatism 67 (2024) 152447] Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-26 Catherine Hofstetter, Shawna Grosskleg, Clayon B. Hamilton, Alison M Hoens, Beverley Shea, Peter Tugwell, Dorcas Beaton
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Can a simple 0–10 RheuMetric physician estimate of inflammatory activity (DOCINF) depict a detailed swollen joint count (SJC) as accurately as a DAS28 or CDAI in patients with rheumatoid arthritis? Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-22 Theodore Pincus, Tengfei Li, Rahel Hunter, Nicholas Rodwell, Kathryn A Gibson
To compare a 0–10 physician subglobal estimate of inflammatory activity (DOCINF) on a RheuMetric checklist to a formal swollen joint count (SJC) and other rheumatoid arthritis (RA) Core data set measures in a disease activity score 28 (DAS28), clinical disease activity index (CDAI), and simplified disease activity index (SDAI) in patients with RA, recognizing that RA measures, index scores and physician
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Role of intravenous immunoglobulins in systemic sclerosis (SSc): A systematic literature review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-22 Sasza Koczanowski, Kathleen Morrisroe, Jessica Fairley, Mandana Nikpour, Shereen Oon, Zoe Brown
Systemic sclerosis (SSc) is a heterogenous, multi-system autoimmune disease that causes progressive fibrosis of the skin and internal organs, resulting in high morbidity and mortality. Intravenous Immunoglobulin (IVIG) is a therapeutic option for SSc; however, reports of its efficacy have been variable, and its use across multiple organ manifestations of SSc has not been comprehensively reviewed. The
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Prevalence of crystal deposits in asymptomatic hyperuricemia according to different scanning definitions: A comparative study Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-20 María-Luisa Peral-Garrido, Silvia Gómez-Sabater, Rocío Caño, Alejandra Bermúdez-García, Teresa Lozano, Ruth Sánchez-Ortiga, Miguel Perdiguero, Elena Caro-Martínez, Carolina Ruiz-García, Rubén Francés, Eliseo Pascual, Mariano Andrés
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Self-esteem, self-concept, and body image of young people with rheumatic and musculoskeletal diseases: A systematic literature review Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-16 Leticia Leon, Daniel Clemente, Carmen Heredia, Lydia Abasolo
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Detection of anti-calreticulin antibody in the sera of Chinese patients with primary Sjögren syndrome Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-15 Shiju Chen, Hongyan Qian, Fan Dai, Guihua Fan, Huiqin Lu, Chaoqiong Deng, Yingying Shi, Yan He, Xinwei Zhang, Guixiu Shi, Yuan Liu
Primary Sjögren syndrome (pSjS) is one of the most prevalent systemic autoimmune diseases and characterized with hyperactivation of B cell and the abundant presence of autoantibodies in sera. The salivary gland epithelial cells (SGECs) release autoantigens to evoke autoimmunity through releasing elevated apoptosis or secreting autoantigen-containing exosomes, thus identifying autoantibodies directly
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Janus kinase inhibition (JAKi) therapy in refractory anti-synthetase syndrome: A retrospective cohort study Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-03 Xueyan Shan, Shiyu Wu, Xixia Chen, Yongpeng Ge
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Clinical management of lupus in the United States: A claims-based analysis Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-03 Kathryn M. Kingsmore, John M. Zent, Peter E. Lipsky
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Impact of inflammation and anti-inflammatory therapies on the incidence of major cardiovascular events in patients with ankylosing spondylitis: A population-based study Semin. Arthritis Rheum. (IF 4.6) Pub Date : 2024-06-03 Lin-Hong Shi, Steven Ho Man Lam, Ho So, Huan Meng, Lai-Shan Tam