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Nutrition in pediatric end-stage liver disease. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-09-12 Tejas S Desai,Jessie M Hulst,Robert Bandsma,Sagar Mehta
PURPOSE OF THE REVIEW The aim of this review is to outline recent studies relating to nutritional status and outcomes in pediatric end-stage liver disease. MAIN FINDINGS Pediatric patients with chronic and end-stage liver disease are at high risk of malnutrition. Given additional growth demands in children and the inherent complications of chronic liver disease, achieving adequate nutrition in these
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Vitamin D and muscle health: insights from recent studies. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-09-05 Akiko Kuwabara,Mai Matsumoto,Yoichi Hatamoto,Satoshi Fujita
PURPOSE OF REVIEW The purpose of this review is to critically evaluate the effects of vitamin D on muscle mass and physical/muscle function in middle-aged and older adults, based on recent human studies, including cross-sectional, observational, and intervention studies. Vitamin D, beyond its well established role in bone health, has shown potential in influencing muscle physiology, making it a nutrient
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Vitamin D in the critically ill - update 2024. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-27 Christina Geiger,James Dayre McNally,Kenneth B Christopher,Karin Amrein
PURPOSE OF REVIEW This review aims to summarize the latest publications on vitamin D focused on critically ill patients. RECENT FINDINGS Vitamin D deficiency is common in critically ill patients (children and adults) and associated with a higher risk for mortality and morbidity as well as sepsis, acute respiratory failure, acute renal failure and prolonged ICU stay. As it is an inexpensive substance
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Prediabetes and insulin resistance: effect of vitamin D. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-27 Tetsuya Kawahara
PURPOSE OF REVIEW The impact of vitamin D on improving insulin resistance in prediabetes remains controversial. The purpose of this review is to examine whether vitamin D supplementation improves insulin resistance in adults with prediabetes, and if so, to identify the mechanisms and the specific populations. RECENT FINDINGS Global prevalence of prediabetes is increasing, and prevention is a critical
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Assessing malnutrition: progress made, but questions remain. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-08 Jann Arends,Dwight E Matthews
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Global Leadership Initiative on Malnutrition cachexia: an inflammation-first approach for the diagnosis of disease-related malnutrition. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-08 Josh McGovern, Richard J E Skipworth, Barry J A Laird, Donald C McMillan
The following article examines the rationale for an inflammation-first approach for diagnosing cachexia and how the current Global Leadership Initiative on Malnutrition (GLIM) framework may be adapted to facilitate this.
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Energy balance and obesity: the emerging role of glucagon like peptide-1 receptor agonists. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-06 Noémie Beauregard, Kurt McInnis, Gary S Goldfield, Éric Doucet
With obesity affecting over one billion people globally, understanding and managing this complex condition is more crucial than ever. This review explores the emerging role of GLP-1 receptor agonists (GLP-1RA) in weight management, focusing on their impact on energy balance. It highlights the necessity of this investigation due to the limited knowledge on both the short-term and long-term implications
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Long-chain n-3 polyunsaturated fatty acid supplementation and neuromuscular function in older adults. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-06 Oliver Hayman, Emilie Combet, Oliver C Witard, Stuart R Gray
This review aims to explore the latest research investigating the effects of marine-derived long-chain n-3 polyunsaturated fatty acid (LCn-3 PUFA) supplementation on neuromuscular function in older adults.
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Progress in physiologically based pharmacokinetic-pharmacodynamic models of amino acids in humans. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-05 Taylor J McColl, David C Clarke
Amino acids are critical to health, serving both as constituents of proteins and in signaling and metabolism. Amino acids are consumed as nutrients, supplements, and nutraceuticals. Much remains to be learned about amino acid function. Physiologically based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling is an emerging tool for studying their complex biology. This review highlights recent PBPK-PD
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Dietary protein in the ICU in relation to health outcomes. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-08-02 Danielle E Bear, Matthew J Summers, Lee-Anne S Chapple
Critical care nutrition guidelines recommend provision of higher protein doses than recommended in health. These recommendations have been predominately based on lower quality evidence and physiological rationale that greater protein doses may attenuate the significant muscle loss observed in critically ill patients. This review discusses the mechanistic action of protein in the critically ill, details
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Dietary protein splanchnic uptake and digestibility via stable isotope tracers. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-07-25 Jake Cox, Daniel James Wilkinson, Philip James Atherton, Kenneth Smith
Dietary proteins are broken down into peptides across the gastrointestinal tract, with skeletal muscle being a primary deposition site for amino acids in the form of incorporation into, for example, metabolic and structural proteins. It follows that key research questions remain as to the role of amino acid bioavailability, of which protein digestibility and splanchnic sequestration (absorption and
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The interplay between gut microbiome and physical exercise in athletes. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-07-19 Marcus Vinicius L Dos Santos Quaresma, Laura Mancin, Antonio Paoli, João Felipe Mota
The gut microbiome regulates several health and disease-related processes. However, the potential bidirectional relationship between the gut microbiome and physical exercise remains uncertain. Here, we review the evidence related to the gut microbiome in athletes.
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Detecting sarcopenia in obesity: emerging new approaches. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-07-10 Gianluca Gortan Cappellari, Michela Zanetti, Lorenzo Maria Donini, Rocco Barazzoni
Sarcopenic obesity is a likely common, but certainly underestimated obesity phenotype, with an important negative clinical impact. Its definition and diagnosis have however remained elusive until recently.
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Assessing cachexia in obesity: contradiction or perfectly possible? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-07-05 Vickie E Baracos
Existing definitions of clinically important weight loss in patients with cancer do not specifically address weight loss in patients who are obese at presentation. This review explores the clinical impact of weight loss and depletion of the skeletal muscle mass (i.e., criteria defining cancer cachexia), in patients with obesity.
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Intestinal adaptation and rehabilitation in adults with short bowel syndrome. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-07-04 Loris Pironi
Over the past decade, trophic gastrointestinal hormonal factors have been included in the intestinal rehabilitation programs for short bowel syndrome (SBS). Up today the only trophic factor approved for clinical practice is the glucagon-like peptide-2 (GLP-2) analogue, teduglutide. A literature review on the last 2-year data on GLP-2 analogues for the treatment of SBS in adults has been performed.
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Dietary fats as regulators of neutrophil plasticity: an update on molecular mechanisms. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-07-02 Anna Parolini, Lorenzo Da Dalt, Giuseppe Danilo Norata, Andrea Baragetti
Contemporary guidelines for the prevention of cardio-metabolic diseases focus on the control of dietary fat intake, because of their adverse metabolic effects. Moreover, fats alter innate immune defenses, by eliciting pro-inflammatory epigenetic mechanisms on the long-living hematopoietic cell progenitors which, in the bone marrow, mainly give rise to short-living neutrophils. Nevertheless, the heterogenicity
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Assessment of iron status. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-06-10 Ann Von Holle
Iron is an essential trace element in human health that can be harmful at abnormal levels such as iron overload or deficiency. Measured iron status in the body can depend on health outcomes experienced by the individual and this can complicate its accurate assessment. This review will highlight recent research on iron assessment in the literature.
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Carbohydrates in the context of metabolic diseases. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-06-06 Lia Bally,Leonidas G Karagounis
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Editorial: unravelling the trifecta: obesity, cancer, and DNA damage. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-06-06 Anastasia Z Kalea,Dorothy Klimis-Zacas
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The impact of slowly digestible and resistant starch on glucose homeostasis and insulin resistance. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-06-06 Maëliss Chisbert, Anne-Laure Castell, Sophie Vinoy, Julie-Anne Nazare
This review will summarize recent studies assessing the effect of slowly digestible starch (SDS) and resistant starch (RS) on glucose metabolism in healthy, prediabetic or type 2 diabetic adults.
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Lactose malabsorption and intolerance in older adults. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-06-06 Antonella Gallo, Emanuele Marzetti, Simona Pellegrino, Massimo Montalto
Lactose malabsorption and intolerance are very common conditions. However, their optimal approach, including the diagnostic assessment, remains a matter of debate, especially in advanced age. In this brief review, we focused on current knowledge, concerns, and impact in clinical practice of lactose malabsorption and intolerance in elderly.
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Nutritional risk screening: a need to guide Alice in Nutritionland. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-06-06 Harriët Jager-Wittenaar, Martine Sealy, Elke Naumann, Marian de van der Schueren
With the shifts in society, healthcare and the profile of the malnourished individual, a re-consideration of the goal of nutritional risk screening is needed: screening for malnutrition, or screening for risk of malnutrition? In this review article, we reflect on the role of nutritional risk screening in relation to prevention and treatment of malnutrition.
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Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-05-22 Amelia Faradina, Alexey A Tinkov, Anatoly V Skalny, Jung-Su Chang
Deficiencies in micronutrients persist as widespread global challenges, where supplementation remains a crucial therapeutic approach. This review aims to elucidate the intricate relationships between micronutrient supplementation - specifically iron, selenium (Se), and vitamin D (Vit D) - and gut microbiota composition, investigating their collective impact on host health and disease susceptibility
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A look inside the gut as a clue to nutritional status. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-05-22 Nir Bar, Siham Abdelgani, Simon Lal, Liat Deutsch
Malabsorption and malnutrition are common gastrointestinal manifestations clinicians face, requiring diagnostic workup for effective diagnosis and management of the underlying cause. This review discusses recent advances in diagnostic approaches to malabsorption and maldigestion of macronutrients - lipids, proteins, and carbohydrates. We highlight underrecognized causes, available testing modalities
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Risks and benefits of nonsugar sweeteners: conflicting evidence between observational studies and randomized controlled trials. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-05-20 David Faeh
Recommendations on the use of nonsugar sweeteners are contradictory, even if they come from official sources. The aim is to review and discuss recent findings on the potential impact of nonsugar sweeteners on human health.
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Role of dietary fibres in cardiometabolic diseases. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-05-16 Christina C Dahm, Fie Langmann, Anne Østergaard Nannsen, Daniel B Ibsen
This review highlights recent developments in understanding the role of dietary fibre and specific fibre types on risk and management of cardiometabolic disease with a focus on the causal pathways leading to cardiometabolic diseases, namely weight management, glycaemic control, and lipid levels, as well as the latest findings for cardiovascular disease outcomes such as coronary heart disease, stroke
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Nutrition support, carbohydrate feeding and insulin sensitivity in the critically ill patient: a complex relationship. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-05-08 Ra'eesa Doola, Claire Dupuis, Jean-Charles Preiser
This review aims to summarize recent studies that highlight the complex relationship between nutrition, carbohydrate, insulin provision and glycaemic control in the critically ill patient population.
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DNA damage, obesity and obesity-related health complications: what are new data telling us? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-04-22 Marta Włodarczyk, Grażyna Nowicka
Obesity is associated with increased DNA damage, which may in turn contribute to the development of obesity-related complications. DNA damage can also affect adipocyte biology, resulting in increased adiposity. Carefully managed weight loss programs can reverse this process. This article surveys new data that support these contentions.
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Role of sex in nutrition research in aging and wasting disease. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-04-04 Mariëlle P K J Engelen,Barbara S van der Meij
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Amino acids and protein sources as therapeutic regulators and modulators. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-04-04 Rajavel Elango,Claire Gaudichon
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Guidance on paediatric nutrition should follow quality standards and be evidence based: concerns regarding the recent WHO guideline on complementary feeding. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-04-04 Berthold Koletzko,Raanan Shamir
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Editor-in-chief announcement: thank you yvon, welcome mette! Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-04-04 Luc Cynober
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Impact of iodine supply in infancy and childhood. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-28 Dominique Turck
To assess the most relevant articles on the impact of iodine supply in at-risk populations, namely infants and young children, pregnant and lactating women.
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Circulating factors in cancer cachexia: recent opportunities for translational research. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-27 Marina de Castro Coêlho, Giovana Parreira de Aquino, Amanda Soares Santos, Marilia Seelaender
To discuss the recent discoveries and limitations of the available literature on emerging circulating biomarkers of cancer cachexia.
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Age-related and cancer-related sarcopenia: is there a difference? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-21 Federico Bozzetti
PURPOSE OF REVIEW The aim of this review is the attempt to differentiating the pathophysiologic and clinical features of the aging-related sarcopenia from cancer-related sarcopenia. In fact, there is some controversy among the experts mainly regarding two points: is always sarcopenia, even that aging-related one, the expression of a generalized disease or may exist independently and without major alteration
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Sarcopenic obesity and the impact on bone health. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-20 Silvia Migliaccio, Edoardo Mocini, Marianna Minnetti, Lorenzo Maria Donini
Sarcopenic obesity is a newly identified pathological entity defined by an increase in body fat mass with an associated sarcopenia, characterized by loss of muscle mass, strength, and function. Recently, the concomitant presence of skeletal alteration with sarcopenic obesity has been described leading to a new clinical entity defined osteosarcopenic obesity (OSO). Many studies have tried to unravel
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Evidence on docosahexaenoic acid and arachidonic acid supplementation for preterm infants. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-18 Alexandre Lapillonne, Chiara Lembo, Sissel J Moltu
For many decades, docosahexaenoic acid (DHA) supplementation was tested in premature infants to achieve an intake equivalent to the average level in breast milk, but this approach has led to conflicting results in terms of development and health outcomes. Higher doses of DHA closer to fetal accumulation may be needed.
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Microbiome and its impact on fetal and neonatal brain development: current opinion in pediatrics. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-12 Nina M Frerichs,Tim G J de Meij,Hendrik J Niemarkt
PURPOSE OF REVIEW Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment and cognitive functioning via a bi-directional communication system known as the microbiota-gut-brain axis (MGBA). RECENT FINDINGS The MGBA influences brain development and function via the hypothalamic-pituitary axis, the vagal nerve, immune signaling, bacterial production of neurotransmitters
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Micronutrient deficiency and supplements in schoolchildren and teenagers. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-11 Mette M Berger, Alan Shenkin
The essential micronutrients are corner stones in the functional and physical development. Early deficiency has life-long consequences. While awareness about iron deficiency is relatively high, it remains lower for other micronutrients. This review aims at reporting on recent data and attracting attention to the high prevalence of micronutrient deficiencies in school-age and adolescent individuals
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Should we provide edible insects in children's diets? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-11 Tele Chepkoros Boit, Alida Melse-Boonstra, Kim F Michaelsen, Nanna Roos
Diets low in animal-source foods or solely consisting of plant-based foods, hardly meet nutrition needs of children, exposing them to inadequate intake of essential nutrients. Thus, including edible insects in children's diets is relevant for meeting nutritional requirements, other potential health benefits, and building more sustainable food systems. Nutrition and health research on insects is novel
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Plant proteins: are they a good alternative to animal proteins in older people? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-03-04 Lina Toutirais, Carole Vaysse, Marine Gueugneau, Stephane Walrand
This review provides the latest insight into the impact of consuming plant-based protein for older people.
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An update on dietary therapies in paediatric Crohn's disease. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-29 Konstantinos Gkikas, Vaios Svolos, Bernadette White, Konstantinos Gerasimidis
This article provides a literature update on original articles published in the past 18 months (May 2022-November 2023) in the dietary management of paediatric Crohn's disease.
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Novel dietary strategies to manage sarcopenia. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-23 Pierre-Emmanuel Cailleaux,Pierre Déchelotte,Moïse Coëffier
PURPOSE OF REVIEW Sarcopenia is a wasting disease, mostly age-related in which muscle strength and mass decline, such as physical performance. With aging, both lower dietary protein intake and anabolic resistance lead to sarcopenia. Moreover, aging and sarcopenia display low-grade inflammation, which also worsen muscle condition. In this review, we focused on these two main targets to study dietary
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Exercise and nutrition interventions for renal cachexia. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-22 Adrian Slee, Joanne Reid
Renal cachexia is a deleterious condition characterized by weight loss, muscle wasting and loss of physical function, quality of life, and increased mortality. Multimodal treatment strategies utilizing exercise and nutrition interventions have been recently suggested although the evidence base is still in its infancy. This paper aimed to review the current literature surrounding the use of exercise
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Tryptophan metabolism and kynurenine metabolites in cancer: systemic nutritional and metabolic implications. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-13 Alessio Molfino, Giovanni Imbimbo, Carmen Gallicchio, Maurizio Muscaritoli
To describe the role of Tryptophan (Trp) metabolism and Kynurenine (Kyn) metabolites in nutritional and metabolic changes in cancer.
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Myoprotective whole foods, muscle health and sarcopenia in older adults. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-13 Antoneta Granic, Rachel Cooper, Sian M Robinson, Avan A Sayer
Sarcopenia increases in prevalence at older ages and may be exacerbated by poor diet. Whole foods rich in specific nutrients may be myoprotective and mitigate the risk of sarcopenia. Here we review recent evidence published from observational and intervention studies regarding myoprotective foods and explore their benefit for the prevention and/or treatment of sarcopenia in older adults.
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Editorial: The interaction between protein delivery and blood urea and ammonia during critical illness. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-08 Adam M Deane,Michael P Casaer
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Editorial: Quantitative and qualitative aspects of lipids and lipoproteins in health and disease: nutrition, physiology and genetics. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-08 Philip C Calder,Gerald F Watts
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The use of machine learning in paediatric nutrition. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-02-01 Aneurin Young, Mark J Johnson, R Mark Beattie
In recent years, there has been a burgeoning interest in using machine learning methods. This has been accompanied by an expansion in the availability and ease of use of machine learning tools and an increase in the number of large, complex datasets which are suited to machine learning approaches. This review summarizes recent work in the field and sets expectations for its impact in the future.
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Nourishing the gut: the impact of diet on host-gut microbiota interaction. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-01-18 Davide Masi, Tiphaine Le Roy, Solia Adriouch, Karine Clément
Understanding the spectrum of drivers that influence the gut microbiome (GM) remains a crucial field of investigation. Among these factors, diet has received particular attention, as it could explain up to 20% of the variability in GM composition between individuals. This review focuses on the complex relationships between different dietary patterns and GM in humans, based on recent findings.
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Metabolic management of accidental intoxication. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-01-18 Khalid Khatib, Subhal Dixit, Madhavi Telang
Unintentional intoxication comprises a major chunk of all intoxications. Most patients are in the pediatric age group with another set of patients being the elderly. Substances found to cause accidental intoxication vary from country to country and even within different regions of a country. Frequent reviews of current literature are needed to be abreast of trends.
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Metabolic failure due to thiamine deficiency during critical illness. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-01-11 Cristian Cobilinschi, Cosmin-Andrei Andrei, Ioana Marina Grinţescu, Liliana Mirea
Thiamine is a crucial component in cellular energy metabolism, serving as a cofactor for multiple enzymatic processes and also having a role in regulating neuronal and neuromuscular transmission. Also it exerts antioxidant proprieties. The objective of this review is to consolidate and assess the most recent research concerning the consequences of insufficient thiamine levels for critically ill patients
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Nutritional management during critical illness in those with previous obesity surgery. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-01-04 Maria Isabel Toulson Davisson Correia,Ricardo Schilling Rosenfeld
PURPOSE OF REVIEW The prevalence of overweight and obesity in our society is a pressing concern that has demanded immediate attention. Traditional treatments have proven ineffective for many individuals, leading to a surge in bariatric surgery as a last resort. While the rate of early and late postoperative complications may be low, when they occur, they place these patients at higher risk of requiring
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Modulation of beta-hydroxybutyrate in traumatic brain injury. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-01-04 Niraj Arora, Dhaval Hitendrakumar Shastri, Utsav Prakashbhai Patel, Kunal Bhatia
Traumatic brain injury (TBI) is a significant public health concern with substantial morbidity and mortality rates in the United States. Current management strategies primarily focus on symptomatic approaches and prevention of secondary complications. However, recent research highlights the potential role of ketone bodies, particularly beta-hydroxybutyrate (BHB), in modulating cellular processes involved
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The use of triiodothyronine during critical illness. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2024-01-04 Matthew J Maiden, Simon Forehan
Thyroid hormone physiology changes during critical illness. Circulating concentration of triiodothyronine (T3), the active form of thyroid hormone decreases. It has long been uncertain whether this represents a pathologic change or if it is an adaptive phenomenon. Controlled clinical trials have been required to understand whether replacing and restoring serum T3 levels is therapeutic.
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Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2023-12-26 Bilal E Kerman, Wade Self, Hussein N Yassine
Most omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation clinical trials report inconsistent or null findings on measures of cognition or Alzheimer's disease (AD) with a relatively large variability in the response to n-3 PUFA supplementation. The purpose of this review is to identify whether the gut microbiome together with the metabolome can provide critical insights to understand this
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Preexercise and postexercise nutrition in older persons: what to eat and when to eat it? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2023-12-14 Stéphane Walrand,Jürgen M Bauer
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Alternative sources of bioactive omega-3 fatty acids: what are the options? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2023-12-08 Ella J Baker
The very-long chain (VLC) omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) promote optimal development, physiological function and healthy ageing and help to manage disease. EPA and DHA are sourced mainly from fish, which is not sustainable. This review explores alternative sustainable sources.
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Casein glycomacropeptide in phenylketonuria: does it bring clinical benefit? Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2023-12-04 Anne Daly, Fatma Ilgaz, Alex Pinto, Anita MacDonald
Casein glycomacropeptide (CGMP) is a milk-derived bioactive sialyated phosphorylated peptide with distinctive nutritional and nutraceutical properties, produced during the cheese making process. It comprises 20-25% of total protein in whey products. CGMP is low in phenylalanine (Phe) and provides an alternative to Phe-free amino acids as a source of protein equivalent for patients with phenylketonuria
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Fluid therapy in diabetic ketoacidosis. Curr. Opin. Clin. Nutr. Metab. Care (IF 3.0) Pub Date : 2023-12-01 Mahesh Ramanan, Anthony Delaney, Balasubramanian Venkatesh
To evaluate recent evidence (2021-2023) on fluid therapy in diabetic ketoacidosis. Key evidence gaps which require generation of new evidence are discussed.