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68 Ga-DOTATATE PET/CT Versus 18 F-FDG PET/CT in TENIS Syndrome: A Head-to-Head Comparison With Elevated and Suppressed TSH Levels in Papillary Thyroid Carcinoma-A Pilot Study. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-12 Ludmila Santiago Almeida,Allan Santos,Lígia Assumpção,Tiago Oliveira Costa,Maidane Araujo,Mariana Lima,Denise Engelbrecht Zantut-Wittmann,Elba Etchebehere
BACKGROUND TENIS syndrome is characterized by reduced expression of sodium-iodine symporter, rising serum thyroglobulin (Tg) levels, and negative whole-body 131 I scans. In such patients, somatostatin receptor imaging with 68 Ga-DOTATATE PET/CT (somatostatin receptor [SSR] PET/CT) and 18 F-FDG PET/CT (FDG PET/CT) can identify metastases and were compared under 2 conditions: elevated (eTSH) and suppressed
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To PE or Not to PE: Perfusion SPECT/CT Avoids Overdiagnosis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-12 Aamir Ali,Akilan Gopal,Yang Lu
A 41-year-old woman with metastatic breast cancer presented with dyspnea, hypoxia, and elevated d -dimer. Perfusion planar imaging followed by SPECT/CT of the chest was performed due to the patient's iodinated contrast allergy. Planar images showed multiple pleural-based wedge-shaped defects concerning for bilateral pulmonary embolism (PE). Perfusion SPECT/CT of the chest confirmed multiple areas of
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68 Ga-FAPI Response Evaluation Pitfall in a Patient With Esophageal Cancer After Neoadjuvant Therapy. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-12 Huipan Liu,Yuhong Liu,Jianwen Zhang,Yue Chen
We report the 68 Ga-FAPI PET/CT findings of inflammatory changes and fibrosis in a 55-year-old woman with a history of esophageal cancer after neoadjuvant therapy, which needs to be differentiated from other esophageal diseases during evaluation.
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CXCR4-Targeted PET Imaging in Hematologic Malignancies: A Systematic Review and Meta-analysis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-11 Mohammadreza Chavoshi,Seyed Ali Mirshahvalad,Andres Kohan,Claudia Ortega,Ur Metser,Adam Farag,Robert Kridel,David Hodgson,Sita Bhella,Vishal Kukreti,Patrick Veit-Haibach
PURPOSE The aims of this study were to perform a comprehensive review and meta-analyses and to report pooled diagnostic results on CXCR4-targeted PET, particularly considering detection, visualization, and prognostication. PATIENTS AND METHODS This study followed PRISMA-DTA. A systematic search was conducted on major medical literature databases up to March 1, 2024. The search strategy was designed
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Peritoneal Metastasis of Osteosarcoma in 99mTc-MDP SPECT/CT Imaging. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-03 Chentian Shen
An 11-year-old boy with history of conventional high-grade osteosarcoma in the left distal femur was referred to our department for 99mTc-MDP whole-body bone scan. In addition to multiple bone lesions and pleura, abnormal high radioactivity was found in the abdomen. SPECT/CT revealed diffuse peritoneal thickening with calcification and increased radioactive uptake, which suggest peritoneal metastases
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Liver and Kidney Tumor Masses as the Initial Presentation of B-Cell Acute Lymphoblastic Leukemia. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-03 Xiaoyu Liu,Jianping Zhong
We described a 13-year-old girl who presented unexplained paroxysmal sharp pain in the right upper abdomen for 3 days. CT and MRI showed multiple masses in the liver and kidneys, initially diagnosed as lymphoma. The hepatic mass biopsy confirmed B-cell lymphoblastic lymphoma. FDG PET/CT examination found that the liver and kidney masses demonstrated high metabolic activity, with concomitant increased
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68Ga-FAPI PET/CT Depicted the Fibrosis of Ischemic Colitis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-09-03 Jieling Zheng,Qian Ru,Yun Yang,Weibing Miao
Ischemic colitis is the most common form of ischemic bowel disease; identification of ischemic colitis with PET/CT is rare. We present a case of unexplained ischemic colitis in a 66-year-old man who underwent 18F-FDG PET/CT to exclude intestinal malignancy and was subsequently recruited in a clinical trial regarding 68Ga-FAPI. 18F-FDG PET/CT showed intense activity in the intestinal lumen where mucosa
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Detection of Muscular Metastasis in a Case of Parathyroid Carcinoma Using 18 F-FAPI-04 PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-10-01 Jie Chen,Min Zhao,Qi An,Lan Wei,Bin Chen
A 46-year-old woman underwent surgery for parathyroid carcinoma 2 years ago. During follow-up, the patient presented with elevated parathyroid hormone (127.50 pg/mL; normal, 15-65). No abnormal uptake of 18 F-FDG or 11 C-choline was observed on 18 F-FDG and 11 C-choline PET/CT imaging. The patient was enrolled in a clinical trial for 18 F-FAPI PET/CT imaging, revealing a lesion with intense focal uptake
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Nivolumab and Cabozantinib Immunotherapy Induced Thyroid Dysfunction Detected on 18 F-FDG PET/CT in Renal Cell Carcinoma. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-10-01 Moulish Reddy,Mudalsha Ravina,Harish Goyal,Amit Kumar,Rutuja Kote
Targeted immunotherapy became the most advanced approach for cancer treatment. Programmed death-1 (PD-1) expressed on activated T cells can reverse immune suppression and cause T-cell activation. Nivolumab, a PD-1 immune checkpoint inhibitor antibody that is a fully human immunoglobulin G4, blocks PD-1 and promotes antitumor immunity. Cabozantinib (tyrosine kinase inhibitor) inhibits the tyrosine kinase
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Elevated 131 I Activity in Adrenal Cyst in a Patient With Thyroid Cancer. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-10-01 Wei Liu,Xiao Yang,Weidong Gong,Jianqiang Wang,Xueyuan Fan
A 23-year-old man with papillary thyroid cancer underwent radioiodine ( 131 I) treatment following total thyroidectomy and node dissection. Posttreatment 131 I SPECT/CT images revealed an additional focus of increased 131 I activity in the left adrenal gland, raising suspicion for possible adrenal metastasis. Ultimately, pathological examination confirmed the diagnosis of an adrenal cyst.
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Early Impact of Bevacizumab on the 99m Tc-HYNIC-PSMA-11 Uptake in a Case of Recurrent Glioblastoma Multiforme. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-10-01 Tahereh Ghaedian,Abdolmajid Alipour,Abbas Rakhsha,Hamid Nasrollahi,Arash Saffarian
Glioblastoma multiforme (GBM) is a highly vascularized tumor with reported high prostate-specific membrane antigen (PSMA) expression. On the other hand, bevacizumab as an antiangiogenesis drug is increasingly used in the treatment of GBM recurrence. We present a case of GBM recurrence with significant reduction of 99m Tc-HYNIC-PSMA-11 uptake in her tumor 1 week after administration of 2 doses of bevacizumab
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68 Ga-Trivehexin PET/CT in Metastatic Non-Small Cell Lung Cancer to the Brain. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-10-01 Fahad Marafi,Abdulredha A Esmail,Mahmoud A Alfeeli,Alyaa Sadeq
In the era of molecular imaging and eager to study tumor tissues' microenvironment with noninvasive means, the search and development of new radiotracer targeted molecule continue. αvβ6-Integrin is a heterodimeric glycoprotein transmembrane receptor that is unique in that it is expressed exclusively in epithelial cells. It is upregulated in varieties of carcinomas such of the lung, breast, and colon
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Ectopic Cushing Syndrome Localized by 68Ga-DOTA-LM3 PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Moritz B Bastian,Florian Rosar,Caroline Burgard,Arne Blickle,Samer Ezziddin
A 53-year-old woman presented with signs of Cushing syndrome with challenges in diagnosis and localization. A novel somatostatin receptor (SSTR)-targeted PET/CT with 68Ga-DOTA-LM3, an SSTR antagonist, revealed a suspicious focal finding in the pancreatic head, proven to be ectopic Cushing syndrome after surgical resection. This interesting image clearly shows the potential of PET imaging with SSTR
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Increase 68Ga-FAPI Uptake in Urogenital Tuberculosis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Qiuming Yu,Qiang Xie,Xingxing Zhu,Xuemei Wang,Ming Ni
Urogenital tuberculosis is one of common sites of extrapulmonary tuberculosis. A 60-year-old man with an elevated prostate-specific antigen level underwent multiparametric MRI, which revealed abnormal signals in the prostate. However, the 68Ga-PSMA PET/CT results were unrevealing. Subsequent 68Ga-FAPI PET/CT imaging revealed intense radioactivity uptake in the prostate and mild radioactivity uptake
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Primary Cardiac Hemangiopericytoma on 18F-FDG and 68Ga-FAPI-04 PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Chuan Li,Yichuan Deng,Xianwen Hu
Hemangiopericytoma can occur anywhere in the body, mainly including the head and neck soft tissue, retroperitoneum, limbs, lung, pleura, pelvis, and meninges, whereas it arising in cardiac is rarely documented. Herein, we report 18F-FDG PET/CT and 68Ga-FAPI findings of hemangiopericytoma in the heart in a 23-year-old woman.
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68Ga-FAPI-04 PET/CT Imaging in a Patient With Psoriatic Arthritis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Zitong Zhang,Lixiang Yang,Lisha Jiang,Rong Tian,Qianrui Li
We described the findings of 68Ga-FAPI-04 PET/CT of psoriatic arthritis in a 56-year-old man. Intense FAPI uptake was observed alongside the spine and in the joints of bilateral feet and the right hip. 68Ga-FAPI PET/CT is potentially valuable for the evaluation of join involvement and disease activity in patients with psoriasis.
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Uptake of 68Ga-DOTA-FAPI-04 in a Case of Gynecomastia. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Tingting Xu,Feiyu Zhang,Shiyu Zheng,Yue Chen
Herein, we report a case of a man with malignant melanoma exhibiting thickened right breast with increased tracer uptake on 68Ga-DOTA-FAPI-04 PET/CT. Subsequent ultrasound confirmed there was no sign of malignancy and consistent with benign gynecomastia.
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Bilateral Internal Auditory Canal Metastasis From Lung Cancer on FDG PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Liu Xiao,Lin Li,Chunyan Wu,Wenjie Zhang
The occurrence of metastatic tumor in the internal auditory canal is very rare. Thus, we report FDG PET/CT findings of bilateral Internal auditory canal metastasis from lung cancer in a 67-year-old man. FDG PET/CT and MRI showed nodules in the bilateral internal auditory canal with an SUVmax of 5.2. This case hints us that bilateral metastasis should be considered as differential diagnosis when we
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Hot Hearts on Bone Scintigraphy Are Not All Amyloidosis: Hyperoxaluria-Associated Cardiomyopathy. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Ya-Wen Wang,Yan-Ting Xie,Xiao-Xin Sun
A 54-year-old woman with a history of end-stage renal disease was found to have infiltrative cardiomyopathy by echocardiography. 99mTc-pyrophosphate (99mTc-PYP) scintigraphy was positive with a remarkable myocardial uptake. Gene test found a mutation of AGXT, confirming a final diagnosis of primary hyperoxaluria. Radiotracer uptake was due to high myocardial oxalate deposition. This case illustrates
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An Incidental Detection of Breast Cancer Osteolytic Bone Metastasis Using a 99mTc-TRODAT-1 SPECT Scan. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Chun-Liang Kuo,Yu-Hong Chang,Rong-Hsin Yang
This report presents a case of suspected Parkinson disease in a 76-year-old woman with a history of slurred speech, general weakness, unstable gait, and bradykinesia for months. A 99mTc-TRODAT-1 SPECT scan revealed a symmetrically decreased bilateral nigrostriatal system, including bilateral putamen and caudate nuclei. The scintigraphic findings may reflect normal aging or atypical parkinsonism. The
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The Value of PSMA-RADS Version 2.0 in the Assessment of Pulmonary Metastases in Patients With Prostate Cancer and the Improvement of Differential Diagnosis Efficiency by PSMA PET/CT Parameters. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Yan Cui,Xin Zhou,Yufei Song,Shizhen Zhai,Nan Li
PURPOSE The aim of this study was to investigate the application of PSMA-RADS version 2.0 in assessment of pulmonary metastases in patients with prostate cancer and whether PSMA PET/CT parameters provide incremental value. PATIENTS AND METHODS From October 2016 to July 2023, PC patients with pulmonary opacities (including pulmonary metastases, lung cancer, and pulmonary benign opacities) who underwent
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FDG PET/MRI in a Case of Isolated Abdominal Incisional Site Metastasis After Laparoscopic Surgery for Colon Cancer. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Xia Ji,Aisheng Dong,Yang Wang,Changjing Zuo
Abdominal-wall metastasis following laparoscopic surgery for colorectal cancer is rare. We describe FDG PET/MRI findings in a case of isolated abdominal incisional site metastasis after laparoscopic surgery for colon cancer. The abdominal-wall metastasis showed slight hyperintensity on T2-weighted fat-suppressed image and intense focal FDG uptake on PET. This case demonstrates the usefulness of FDG
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Incidental Uptake of 68Ga-DOTA-IBA in Prostate Adenocarcinoma. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Huipan Liu,Yuhong Liu,Feifan Xiang,Jianwen Zhang,Yue Chen
68Ga-labeled DOTA-ibandronic acid (68Ga-DOTA-IBA) is a novel PET agent developed for bone tumors. In addition, 68Ga-DOTA-IBA uptake in nonosseous findings has also been reported. Herein, we present a case of 68Ga-DOTA-IBA uptake in primary prostate adenocarcinoma.
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PET/CT Manifestations of a Case of Cavernous Hemangioma Misdiagnosed as Reproductive Tumor. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Tao Liu,You Cheng,Jian-Jiang Huang,Dan Shao,Si-Yun Wang
Cavernous hemangioma of mediastinum is a rare, benign tumor originating from vascular endothelial cells. It typically arises in the anterior mediastinum but has also been reported in the posterior mediastinum or the middle mediastinum, and occasionally involves both the anterior and middle compartments. We present the case of a 20-year-old man with a cavernous hemangioma of mediastinum initially misdiagnosed
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Elevated 68Ga-FAPI Activity in Tailgut Cyst Adenocarcinoma. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-28 Yilin Huang,Lei Ou,Chengrun Zeng,Xiaoliang Chen
Tailgut cyst adenocarcinoma is a rare malignant tumor. We present 68Ga-FAPI PET/CT findings of tailgut cyst adenocarcinoma in a 46-year-old woman. Tailgut cyst adenocarcinoma on 68Ga-FAPI PET/CT showed increased tracer uptake. This case demonstrates the potential value of 68Ga-FAPI PET/CT for evaluating tailgut cyst adenocarcinoma.
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Efficiency and Safety of Targeted Alpha Therapy in Metastatic Neuroendocrine Tumors: A Meta-analysis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-22 Dong Yun Lee,Yong-Il Kim
PURPOSE Despite the effectiveness of 177Lu-based peptide receptor radionuclide therapy in treating metastatic neuroendocrine tumors (NETs), disease progression posttreatment remains a significant challenge. Targeted alpha therapy (TAT) has emerged as a promising option for patients experiencing such progression. This study aims to assess the therapeutic efficiency and toxicity of TAT in patients with
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Targeted Sacral Biopsy With Portable Gamma Camera and Intraoperative Gamma Probe. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-16 Sandra Rama Alonso, Eva Campaña Díaz, Juan Francisco Blanco Blanco, Paloma García-Talavera San Miguel, Felipe Gómez-Caminero López
A 58-year-old man with dysphagia and trismus symptoms presented a lobulated tumor in the right tonsil and ipsilateral laterocervical stony adenopathies in the physical examination. He had prostate carcinoma as clinical precedent. The tonsilar lesion showed focal FDG uptake (SUVmax, 10.89) on PET/CT and increased glycemic metabolism in the left sacral wing (SUVmax, 10.90) without clear morphological
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Localized 131I Uptake in the Deltoid Muscle Bilaterally After Parathyroid Transplantation. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-16 Maohua Rao, Jiajian Xie, Huihui Zhang, Yan Tian, Liang Cai
A 49-year-old woman patient with thyroid cancer accepted thyroidectomy and parathyroid transplantation. One month later, localized 131I uptake in the deltoid muscle bilaterally was detected by 131I whole-body imaging performed in 2 days after 131I administration.
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Serial 18F-FDG PET/CT Revealing Mixed Histiocytosis in a Pediatric Patient. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-15 Karan Singh, Loretta Lau, Eva A Wegner, Monica A Rossleigh, Ivan Ho Shon
A 6-month-old boy presented with a left parietal soft tissue swelling and CT findings of multiple calvarial lytic lesions. 18F-FDG PET/CT demonstrated hypermetabolic lesions in the left parietal, right occipital, and right femoral bones. The left parietal lesion was excised, and pathology was consistent with Langerhans cell histiocytosis. Interim PET assessment following induction chemotherapy demonstrated
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The Early Perfusion Image Is Useful to Support the Visual Interpretation of Brain Amyloid-PET With 18F-Flutemetamol in Borderline Cases. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-8-6 Franziska L Mathies, Fiona Heeman, Pieter Jelle Visser, Anouk den Braber, Maqsood Yaqub, Susanne Klutmann, Michael Schöll, Elsmarieke van de Giessen, Lyduine E Collij, Ralph Buchert
Visual interpretation of brain amyloid-β (Aβ) PET can be difficult in individuals with borderline Aβ burden. Coregistration with individual MRI is recommended in these cases, which, however, is not always available. This study evaluated coregistration with the early perfusion frames acquired immediately after tracer injection to support the visual interpretation of the late Aβ-frames in PET with 18F-flutemetamol
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A Case of Metastatic Pulmonary Calcification Detected on 99mTc-MDP Bone Scan and 99mTc-FAPI Scan. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-8-6 Pegah Sahafi, Amin Sabertanha, Sajad Ataei Azimi, Kamran Aryana, Atena Aghaee
A 59-year-old woman with recent history of weakness, loss of appetite, and significant weight loss was referred for malignancy workup. On the first day, the patient underwent a 99mTc-MDP scan, which revealed diffuse pulmonary uptake in both lungs. Two days later, 99mTc-FAPI scan was performed and showed diffuse pulmonary uptake in the planar and SPECT/CT images. The study present an interesting case
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The First Case of 99mTc-FAPI Uptake in Optic Nerve Sheath Meningioma. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-8-6 Pegah Sahafi, Farid Jafari Zarrin Ghabaei, Kamran Aryana, Seyed Amir Aledavood, Atena Aghaee
This case study presents the first demonstration of FAPI ligand uptake in a patient with optic nerve sheath meningioma. The patient, a 23-year-old woman who had previously undergone surgery for refractory optic meningioma, was referred to our department for 177Lu-DOTATATE therapy. After 3 cycles of 177Lu-DOTATATE administration, her proptosis significantly decreased. Two months after her last therapeutic
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99mTc-PYP and 68Ga-FAPI PET/CT Images of Hereditary Transthyretin Amyloidosis With Cardiac Involvement. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-8-6 Ali Kibar, Kubra Sahin, Baris Ikitimur, Sait Sager, Haluk Burcak Sayman
Amyloidosis is a protein misfolding disorder characterized by the extracellular deposition of insoluble amyloid fibrils, derived from abnormally folded proteins. These fibrils disrupt tissue structure and function, leading to organ dysfunction. The condition encompasses various subtypes, each associated with distinct precursor proteins and clinical manifestations. 99mTc-PYP scintigraphy is used widely
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68Ga-DOTA-IBA PET/CT and 18F-FDG PET/CT in Ewing Sarcoma. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-06 Feifan Xiang, Huipan Liu, Xiaoqi Tan, Wenzhe Ma, Yue Chen
A 29-year-old man with Ewing sarcoma in the right ankle underwent 68Ga-DOTA-IBA PET/CT and 18F-FDG PET/CT, both of which showed high radiotracer activity for the primary tumor. Interestingly, bone metastases were detected early using 68Ga-DOTA-IBA PET/CT for the sixth thoracic vertebrae and with 18F-FDG PET/CT for the bilateral humerus. Higher uptake of 68Ga-DOTA-IBA was found in both primary and metastatic
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Performance and Clinical Impact of Radiomics and 3D-CNN Models for the Diagnosis of Neurodegenerative Parkinsonian Syndromes on 18F-FDOPA PET. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-06 Thi Khuyen Le, Victor Comte, Jacques Darcourt, Micheline Razzouk-Cadet, Anne-Capucine Rollet, Fanny Orlhac, Olivier Humbert
The aim of this study was to compare the performance and added clinical value of a semiautomated radiomics model and an automated 3-dimensinal convolutional neural network (3D-CNN) model for diagnosing neurodegenerative parkinsonian syndromes on 18F-FDOPA PET images.
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177Lu-PSMA With Olaparib Radiosensitization Potentiates Response and Toxicity in Extensive Castration-Resistant Metastatic Prostate cancer. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-02 Yung Hsiang Kao, Nadia Falzone, Michael Pearson, David Pook, Dinesh Sivaratnam
A patient with widespread intensely prostate-specific membrane antigen-expressing, BRCA gene mutation-positive bone metastases at the time of prostate cancer diagnosis had progressed on multiple lines of standard therapy. He received 177Lu-prostate-specific membrane antigen 8.5 GBq augmented by a short course of olaparib radiosensitization and achieved 90% decrease in serum PSA level after a single
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A False-Negative 123I-MIBG SPECT/CT With True-Positive 68Ga-DOTATATE PET/CT in a Patient With Neuroblastoma Following 177Lu-DOTATATE Therapy. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-02 Siqi Li, Yanfeng Xu, Xia Lu, Wei Wang, Jigang Yang
A 10-year-old girl with high-risk neuroblastoma underwent 123I-MIBG SPECT/CT and 68Ga-DOTATE PET/CT, which both showed multiple bone metastases. However, following 177Lu-DOTATATE therapy, only 68Ga-DOTATATE PET/CT identified residual lesions with negative 123I-MIBG SPECT/CT results. The case emphasized the complementary role of 68Ga-DOTATATE PET/CT and 123I-MIBG SPECT/CT after 177Lu-DOTATATE therapy
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Biodistribution and Radiation Dosimetry for 68Ga-DOTA-CCK-66, a Novel CCK2R-Targeting Compound for Imaging of Medullary Thyroid Cancer. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-02 Oliver Viering, Andreas Rinscheid, Nadine Holzleitner, Alexander Dierks, Malte Kircher, Georgine Wienand, Marianne Patt, Hans-Jürgen Wester, Ralph A Bundschuh, Thomas Günther, Constantin Lapa, Christian H Pfob
Cholecystokinin 2 receptor (CCK2R) is a promising target for imaging and treatment of medullary thyroid cancer due to its overexpression in over 90% of tumor cells. 68Ga-DOTA-CCK-66 is a recently introduced PET tracer selective for CCK2R, which has shown favorable pharmacokinetics in vivo in preclinical experiments. In order to further investigate safety and suitability of this tracer in the human
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Apparently Benign 131I Adrenal Uptake. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-02 Daniela Travaglio Morales, Michael C Kreissl, Florian Fischer, Alexander Heinzel
A 60-year-old man suffering from papillary thyroid cancer (pT2 pN0(0/21) cM0) underwent diagnostic 131I whole-body scintigraphy with recombinant thyroid-stimulating hormone for follow-up after thyroidectomy and adjuvant 131I therapy with 4.2 GBq. A focal uptake of radioiodine was found in the right adrenal gland, which had not been seen on the initial posttherapeutic images; therefore, an adrenal metastasis
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68Ga-DOTA.SA.FAPi PET in Response Assessment After 177Lu-Microspheres Selective Intra-arterial Radionuclide Therapy for Unresectable Hepatocellular Carcinoma. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Sejal Chopra, Yamini Mathur, Frank Roesch, Euy Sung Moon, Harmandeep Singh, Naveen Kalra, Ajay Duseja, Bhagwant Rai Mittal, Jaya Shukla
We report a case of a 48-year-old man with recurrent hepatocellular carcinoma, who underwent FDG PET for restaging and demonstrated mildly tracer-avid arterial enhancing lesion in segment III (SUVmax, 5.7). Owing to low FDG uptake, patient was planned for 68Ga-SA.FAPi PET, which demonstrated higher tracer avidity in the lesion (SUVmax, 24.4). Subsequently, patient underwent 177Lu-microsphere SIRT (2
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FDG PET/CT in Staging of α-Fetoprotein-Producing Hepatoid Adenocarcinoma of the Pancreas. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Xia Ji, Aisheng Dong, Yang Wang
Hepatoid adenocarcinoma of the pancreas is a rare aggressive tumor with poor prognosis. We describe contrast-enhanced CT and FDG PET/CT findings in a case of pancreatic hepatoid adenocarcinoma with significantly elevated α-fetoprotein level presenting as acute pancreatitis. The primary pancreatic tumor diffusely involved the pancreas and showed heterogeneous enhancement mimicking acute necrotizing
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Primary Prostatic Stromal Sarcoma on 18F-PSMA PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Meiyan Chen, Yanliang Dong, Baixuan Xu, Yachao Liu
Primary prostatic stromal sarcoma is extremely rare. Serum PSA is usually normal. Here, we report a case of primary prostatic stromal sarcoma in a 23-year-old man. 18F-prostate-specific membrane antigen (PSMA) PET/CT showed prostate mass and multiple low-density lesions in the liver with high PSMA expression. However, after chemotherapy, the level of PSMA expression in the prostate mass decreased,
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Improvement of Laboratory Hepatic Parameters After Treatment With 177Lu-DOTATATE: Cohort in an Oncology Reference Center. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Filipe Dos Santos Soares, Juliana Ribeiro de Carvalho, Beatriz Arruda Matheos de Lima, Renata Christian Martins Felix, Daniel Alves Bulzico, Priscilla Brunelli Pujatti
Well-differentiated neuroendocrine neoplasms (NETs) overexpress the somatostatin receptor, which is the target for the peptide receptor radionuclide therapy (PRRT). NETs have a slow growth rate and can metastasize to liver, bone, and lungs. In NETs patients, liver metastasis is an important prognostic marker because liver failure is one of the most common causes of death in this population. In this
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The Contribution of 68Ga-FAPI-04 PET/CT to Staging and Prognosis in Gastric Cancer. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Ediz Beyhan, Tevfik Fikret Çermik, Özge Erol Fenercioğlu, Rahime Şahin, Göksel Alçin, Tamer Aksoy, Esra Arslan, Nurhan Ergül
This study aimed to compare the diagnostic capabilities of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT imaging in staging gastric carcinoma, exploring the impact of 68Ga-FAPI-04 PET/CT on treatment planning and its prognostic significance.
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Risk Factors for Rapid Cognitive Decline in Amyloid-Negative Individuals Without Cognitive Impairment or With Early-Stage Cognitive Loss in Screening Tests. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Yong-Jin Park, Joon Young Choi, Kyung-Han Lee, Sang Won Seo, Seung Hwan Moon
Although rapid cognitive decline (RCD) is an important unfavorable prognostic factor, not much is known about it, especially in amyloid-negative individuals. The purpose of this study was to investigate risk factors for RCD in amyloid-negative individuals.
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CXCR4-Targeted 68Ga-Pentixafor PET/CT Imaging in Inflammatory Bowel Disease. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Yang Chen, Hui Yuan, Xiaoyue Tan, Yuxiang Shang, Xiaolin Sun, Peng Wang, Lei Jiang
To investigate the role of CXCR4-targeted 68Ga-pentixafor PET/CT imaging in inflammatory bowel disease (IBD).
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FDG PET/CT in an Interesting Case of Paraneoplastic Relapsing Polychondritis Associated With Adenocarcinoma of the Lung. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Priyavrat Purohit, Komal Preet, Bhagwant Rai Mittal, Rajender Kumar, Harmandeep Singh, Aman Sharma, Navneet Singh
Relapsing polychondritis (RP) is an uncommon autoimmune disease that causes inflammation of the cartilage and proteoglycan-rich structures, including the ear, nose, and airway. Paraneoplastic RP is a subset of RP that occurs in some individuals following the detection and treatment of certain types of cancers. FDG PET/CT helps with early diagnosis of RP, identifying inflammatory areas even in the absence
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Performance and Interpretation of Lung Scintigraphy: An Evaluation of Current Practices in Australia, Canada, France, Germany, and United States. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Romain Le Pennec, Wolfgang Schaefer, Mark Tulchinsky, François Lamoureux, Paul Roach, Christoph Rischpler, Katherine Zukotynski, Christopher O'Brien, Declan Murphy, Pierre Pascal, Grégoire Le Gal, Pierre-Yves Salaun, Pierre-Yves Le Roux
Although ventilation/perfusion (V/Q) scintigraphy is a widely used imaging test, different options are possible for the acquisition and interpretation of the scan. The aim of this study was to assess current practices regarding the use and interpretation of lung scintigraphy in various clinical indications.
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Aspergillus fumigatus: Is Dual-Tracer 18FDG/68Ga-FAPI PET/CT Capable of Distinguishing Fungal Infection and Unspecific Inflammation From Recurrent Lung Cancer? Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Yannik Kullik, Thomas E Wessendorf, Dirk Theegarten, Jane Winantea, Hubertus Hautzel, Marcel Opitz
A 61-year-old woman, referred for recurrent pneumonia over a period of 3 months with insufficient response to antibiotic treatment, presented with coughing and intense right-sided chest pain. Previously, she underwent right upper lobectomy for locally advanced non-small cell lung cancer (squamous cell carcinoma) followed by adjuvant chemotherapy and subsequent partial chest wall resection with pol
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Prognostic Value of Bone Scintigraphy in Cardiac Amyloidosis: A Systematic Review and Meta-analysis. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-08-01 Sang-Geon Cho, Sangwon Han
The prognostic value of bone scintigraphy in cardiac amyloidosis (CA) remains undetermined. We conducted a systematic review and meta-analysis on the association of cardiac uptake on bone scintigraphy with mortality in known or suspected CA.
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Clinical Application of 18F-THK5351 PET to Image Ongoing Astrogliosis in MSA-P and MSA-C. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-22 Soichiro Kondo, Kenji Ishibashi, Kenji Ishii, Atsushi Iwata, Ryoko Ihara
18F-labeled THK5351 PET can visualize ongoing astrogliosis by estimating monoamine oxidase B levels and can be used as an adjunct for diagnosing neurodegenerative disorders. Little has been reported on multiple system atrophy (MSA) in the differential diagnosis of parkinsonian syndromes. Here, we present 18F-THK5351 images in typical cases of MSA-P (parkinsonian type) and MSA-C (cerebellar type), showing
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Diagnosis of Extraosseous Lesions Overlapping the Bones on Bone Scintigraphy. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-22 Bing Bi, Jing Zhu, Na Li, Hangzhi Hu, Fuqiang Shao
Extraosseous MDP uptake was not uncommon on the bone scintigraphy. When the extraosseous activity is overlapping the bones, it might cause difficulty in interpreting the result when only static images were acquired. Here we report 2 cases that abnormal MDP activity overlapping the bones on planar images, which were confirmed as soft tissue lesions by SPECT/CT or CT imaging.
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Postoperative Spindle Cell Nodule Mimicking Metastatic Lesion With Persistently Increasing 68Ga-FAPI-04 Uptake After Receiving Personalized Antigen Peptide Tumor Vaccine. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-22 Yirong Wang, Zhiyong Quan, Yongzhan Nie, Fei Kang, Jing Wang
A 59-year-old woman underwent radical surgery and chemotherapy for gastric adenocarcinoma. After the personalized antigen peptide tumor vaccine, a new nodular lesion, in the upper abdomen, was discovered during 68Ga-FAPI-04 PET/MRI follow-up. To determine possible pseudoprogression, 68Ga-FAPI-04 PET/MRI was repeated 39 days later, referring to immune PET response criteria in solid tumors. The lesion
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Diagnostic Challenges in Invasive Mole With 18F-FDG PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-22 Akihiko Minami, Ryusuke Nakamoto, Takuto Shimamura, Yurika Kitano, Yuji Nakamoto
A 34-year-old woman underwent 18F-FDG PET/CT scan following a diagnosis of an invasive mole. Although CT indicated multiple lung metastases, FDG uptakes were not evident. In contrast, FDG uptakes were observed in the pelvic lesion including the left ovary, suggestive of ovarian metastasis. MRI disclosed a ring-shaped enhancement typical of a corpus luteum. This corpus luteum was supposed to be maintained
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Recent Clinical Implications of FAPI: Imaging and Therapy. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-18 Mahshid Kiani, Safura Jokar, Leila Hassanzadeh, Hossein Behnammanesh, Omid Bavi, Davood Beiki, Majid Assadi
The fibroblast activation protein (FAP) is a biomarker that is selectively overexpressed on cancer-associated fibroblasts (CAFs) in various types of tumoral tissues and some nonmalignant diseases, including fibrosis, arthritis, cardiovascular, and metabolic diseases. FAP plays a critical role in tumor microenvironment through facilitating proliferation, invasion, angiogenesis, immunosuppression, and
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A Rare Atypical Intrapericardial Prostate Adenocarcinoma Metastasis With 68Ga-PSMA-11 PET/CT. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-18 Aurélie Moreau, Mayeul Tabutin, Amine Bouhamama, David Kryza
We report the case of an 88-year-old man recently diagnosed with prostate cancer. The patient underwent a 68Ga-prostate-specific membrane antigen-11 PET/CT for staging assessment. This examination revealed intense and expected uptake in the primary prostate cancer, widespread metastatic involvement including typical adenopathy and bone metastasis, and a less common pulmonary lymphangitic carcinomatosis
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Burned-Out Testicular Carcinoma Presenting as Inferior Vena Cava Tumor Thrombus With Pulmonary Tumor Embolism on FDG PET/CT: A Case Report. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-16 Noa Shani Shrem, Daniel Levin, Keren Rouvinov, Gal Ben-Arie, Ilya Liberzon, Nir Hod
"Burned-out" testicular tumor is a very rare clinical phenomenon, which refers to the presence of a metastatic germ cell tumor with no clinical findings in the testicle due to spontaneous regression of the primary testicular lesion. We present an unusual case of burned-out testicular embryonal germ cell carcinoma presenting as an extensive inferior vena cava tumor thrombus with malignant pulmonary
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A Peculiar Tau Accumulation Pattern Identified Via 18F-Florzolotau PET Imaging in a Patient With Frontotemporal Dementia Caused by a Mutation in the MAPT Gene. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-16 Qijun Li, Hang Li, Zhaoxia Huang, Yanfeng Li, Ruixue Cui
We reported imaging findings with a peculiar tau accumulation pattern in a 56 year-old woman with frontotemporal dementia caused by Q351R mutation in the microtubule-associated protein tau (MAPT) gene. She had a 10-year history of gradually worsening memory loss. 18F-FDG PET demonstrated hypometabolism in medial temporal lobes, but 18F-florbetapir PET manifested no abnormal amyloid beta deposition
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Elevated 68Ga-FAPI Activity in Benign Carotid Body Tumors. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-16 Yang Xie, Wenxin Tang, Xi Chen, Xue Bai, Yue Chen
We present 68Ga-FAPI PET/CT findings of benign carotid body tumor in a 33-year-old woman. Benign carotid body tumor demonstrated intense tracer uptakes on 68Ga-FAPI PET/CT. Our case suggests that benign carotid body tumors should be considered in the differential diagnosis of neck mass with elevated 68Ga-FAPI activity.
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Clinical Factors Affecting Discrepancy Between Predicted and Long-term Actual Lung Function Following Surgery. Clin. Nucl. Med. (IF 9.6) Pub Date : 2024-07-16 Jae-Woo Ju, Minseok Suh, Hongyoon Choi, Kwon Jooong Na, Samina Park, Gi Jeong Cheon, Young Tae Kim
Lung cancer surgery outcomes depend heavily on preoperative pulmonary reserve, with forced expiratory volume in 1 second (FEV1) being a critical preoperative evaluation factor. Our study investigates the discrepancies between predicted and long-term actual postoperative lung function, focusing on clinical factors affecting these outcomes.