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Postmarketing Analysis of Eosinophilic Adverse Reactions in the use of Biologic Therapies for Type 2 Inflammatory Conditions Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-09-17 Dafna Gershnabel Milk, Kent K. Lam, Joseph K. Han
BackgroundTemporary eosinophilia is a potential adverse reaction of monoclonal antibody therapies in the treatment of a variety of type 2 inflammatory conditions, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). The pathophysiology, epidemiology, and clinical significance of eosinophilia and eosinophilic adverse reactions following the initiation of biologic therapy are unclear
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Antimicrobial Prescription Patterns for Acute Sinusitis 2015–2022: A Comparison to Published Guidelines Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-09-14 Sarit Dhar, Dhruv S. Kothari, Ana L. Tomescu, Brian D’Anza, Kenneth Rodriguez, Anthony Sheyn, Sanjeet V. Rangarajan
BackgroundAcute rhinosinusitis (ARS) is one of the most encountered conditions in primary care and otolaryngology clinics. However, little is known about how antibiotic prescription practices following a diagnosis of ARS compare to guidelines set forth by the American Academy of Otolaryngology in 2015.ObjectiveTo investigate the epidemiology of ARS and the corresponding antibiotic prescribing practices
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“Knowledge Is an Unending Adventure at the Edge of Uncertainty.” Jacob Bronowski Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-09-07 John Schneider
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Predictors for Development of Chronic Rhinosinusitis in Transplant Recipients Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-26 Estephania Candelo, Anyull D. Bohorquez-Caballero, Karol Avila-Castano, Lydia A. Mercado, Angela Donaldson
ObjectivesStudies suggest that transplant patients are at a higher risk of developing chronic rhinosinusitis (CRS). However, there is a dearth of studies describing the factors that may be linked to the development of CRS in this population. Our objective is to identify the risk factors associated with the development of CRS in transplant recipients.Study designRetrospective cohort.SettingTertiary
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Intranasal Trigeminal Function in Aging Adults Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-22 Noah Z. Feit, Nicole Kloosterman, Kristina A. LaPointe, Charn Pitiranggon, Isabel E. Finnegan, Carter D. Smith, Mathew J. Gregoski, Nicholas R. Rowan, Zachary M. Soler, Rodney J. Schlosser
BackgroundIntranasal trigeminal function is important in detecting environmental stimuli. The impact of age-associated chemosensory dysfunction upon taste and olfaction is well described, but an understanding of trigeminal loss (chemesthesis) is lacking.ObjectiveThe goal of this study was to characterize trigeminal function in a cohort of older adults and explore potential impacts.MethodsTwenty-eight
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Assessing the Readability, Reliability, and Quality of AI-Modified and Generated Patient Education Materials for Endoscopic Skull Base Surgery Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-22 Michael Warn, Leo L.T. Meller, Daniella Chan, Sina J. Torabi, Benjamin F. Bitner, Bobby A. Tajudeen, Edward C. Kuan
BackgroundDespite National Institutes of Health and American Medical Association recommendations to publish online patient education materials at or below sixth-grade literacy, those pertaining to endoscopic skull base surgery (ESBS) have lacked readability and quality. ChatGPT is an artificial intelligence (AI) system capable of synthesizing vast internet data to generate responses to user queries
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The Evaluation Value of the Modified Lund-Kennedy Nasal Endoscopy Score on the Efficacy of Sublingual Immunotherapy for Allergic Rhinitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-17 Yinglong Zhang, Hong Jiang, Yu Long, Jie Li
ObjectiveAllergic rhinitis (AR) is a growing public health problem worldwide. Respecting the significance of the modified Lund-Kennedy (MLK) score in rhinitis assessment, we delved into its evaluation value on the sublingual immunotherapy (SLIT) efficacy in AR patients.MethodsTotally 100 AR patients were enrolled, with pre- and post-SLIT MLK score, total nasal symptoms score (TNSS), total medication
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Comparative Effectiveness of Dupilumab Versus Sinus Surgery for Chronic Rhinosinusitis With Polyps: Systematic Review and a Meta-Analysis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-16 Do Hyun Kim, Gulnaz Stybayeva, Se Hwan Hwang
BackgroundCurrent treatment paradigms recommend surgical intervention when conventional medical management proves ineffective in resolving chronic rhinosinusitis with nasal polyposis.ObjectivesTo assess and compare the efficacy of dupilumab and functional endoscopic sinus surgery (FESS) for the treatment of chronic rhinosinusitis with nasal polyp (CRSwNP) over time.MethodsStudies comparing CRSwNP patients
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Malvidin From Malva sylvestris L. Ameliorates Allergic Responses in Ovalbumin-Induced Allergic Rhinitis Mouse Model via the STAT6/GATA3 Pathway Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-13 Luo Yirui, Li Tao, Liu Ruowu, Zhou Jiao, Zhou Jing, Xu Xiaodong, Yan Yan, Claus Bachert, Du Jintao, Ba Luo
BackgroundMalva sylvestris L. (commonly known as mallow) has been widely used in traditional Tibetan formulations to treat allergic rhinitis (AR), and malvidin is a key anti-inflammation constituent of this plant.ObjectiveThe present study aimed to evaluate the potential therapeutic effect and mechanism of malvidin in an AR mouse model.MethodsMalvidin's efficacy was evaluated in an AR mouse model induced
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Endoplasmic Reticulum Stress Promotes Telomerase Reverse Transcriptase Expression Contributes to Development of Allergic Rhinitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-08-02 Yun Liao, Xiwen Zhang, Shuang Tao, Shiqi Wang, Qinmiao Huang, Ping Tang, Aifa Tang, Pingchang Yang, Gui Yang
BackgroundThe Th2 cell polarization is a crucial factor in the pathogenesis of allergic diseases. The underlying mechanism requires further investigation. Telomerase has an immune-regulating ability. The aim of this study is to elucidate the association between telomerase and Th2 cell polarization in patients with allergic rhinitis (AR).MethodsCD4+ T cells were isolated from blood samples collected
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Computed Tomography Signs of Sinonasal Inflammation in Patients with Acute Dacryocystitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-07-21 Yueqi Yu, Guangming Zhou, Xinyu Li, Jinfei Wei, Xiaoyu Ke, Linjuan Wu, Wencan Wu, Bo Yu
BackgroundNasal and paranasal sinus abnormalities may be related to nasolacrimal duct obstructive disease but are strongly debated. Data of acute disease stage are lacking.ObjectiveThe purpose of this study was to determine if there are correlations between radiologic signs of sinus inflammation and acute dacryocystitis (AD).MethodsThis cross-sectional controlled study was conducted at Wenzhou, Zhejiang
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Odontogenic Maxillary Sinusitis Microbiology Compared With Chronic Rhinosinusitis: A Meta-Analysis. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-06-17 Chang Lu,Yue Zhao,Yicheng Qin,Xi Zhang,Xiaozhe Yang,Yan Zhao,Xiangdong Wang,Jiang Lin
BACKGROUND Subtypes of sinusitis have different symptoms and prognoses due to different pathogens. Odontogenic maxillary sinusitis (OMS) mainly occurs unilaterally and is different from chronic rhinosinusitis (CRS) usually occurring bilaterally in terms of clinical characteristics. However, comprehensive microbiological comparisons between OMS and CRS have never been systematically conducted and most
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Topical Application of 5-Fluorouracil for the Treatment of Sinonasal Adenocarcinoma and Inverted Papilloma. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-06-07 Lucy Revercomb,Aman M Patel,Ivan Filimonov,David Lerner,Andrey Filimonov
BACKGROUND Sinonasal tumors represent a rare and heterogeneous group of rhinologic neoplasms. Even with advancements in surgical approaches, mortality rates of patients with sinonasal adenocarcinoma (SNAC) have not significantly improved and persistently high rates of recurrence in certain patients with inverted papilloma (IP) are seen. The use of 5-fluorouracil (5-FU) has been successfully described
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Management of the Nasolacrimal Duct in Expanded Endoscopic Approaches to the Maxillary Sinus: A Systematic Review with Evidence-based Recommendations Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-05-28 Neal Rajan Godse, Satyan Sreenath, Brian C. Lobo, Raj Sindwani
BackgroundUtilizing expanded endoscopic approaches to the maxillary sinus for the endonasal management of a variety of tumors is increasing in popularity. The nasolacrimal duct (NLD) may be injured inadvertantly or need to be removed during tumor resection or to augment visualization. Management of the NLD can take the form of transection alone, transection with stenting, or performing a formal dacryocystorhinostomy
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Transcutaneous Retrobulbar Amphotericin B Injection for Invasive Fungal Sinusitis with Orbital Involvement: A Systematic Review Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-05-22 Hasan Abdulbaki, Jacquelyn K. Callander, Judd H. Fastenberg, Matthew S. Russell, M. Reza Vagefi, Robert C. Kersten, Patricia A. Loftus
BackgroundOrbital involvement of invasive fungal sinusitis (IFS) is an ominous prognostic marker that should prompt rapid intervention. Transcutaneous retrobulbar administration of amphotericin B (TRAMB) is an off-label adjunctive treatment that can increase drug penetrance into diseased orbital tissue. To date, there is a lack of consensus regarding the use of TRAMB for treatment of IFS with orbital
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Prevalence and Magnitude of Olfactory Dysfunction in Allergic Rhinitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-05-17 Marco A. Fornazieri, Ellen C.D. Garcia, Ricardo H. Montero, Ricardo Borges, Thiago F.P. Bezerra, Fábio R. Pinna, Richard L. Doty, Richard L. Voegels
BackgroundAlthough allergic rhinitis (AR) can negatively impact the ability to smell, the degree to which this occurs is not clear and prevalence estimates vary among studies. This study had 4 main objectives: (1) To estimate the prevalence and the degree of olfactory dysfunction in AR patients; (2) To compare olfactory perception between AR patients with different persistence and severity of symptoms
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Serum Aspergillus fumigatus-Specific IgG as a Complementary Biomarker in Differentiating Endotypes of Chronic Rhinosinusitis: A Study on Its Role and Diagnostic Efficacy in Type 2 Inflammation Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-05-16 Pei-Tzu Hung, Hsiang-Sheng Wang, Ta-Jen Lee, Chi-Che Huang, Po-Hung Chang, Yi-Wei Chen, Chia-Hsiang Fu
BackgroundAspergillus is one of the most common pathogens causing fungal allergy in the respiratory tract. Serum Aspergillus fumigatus-specific immunoglobulin G (Af-sIgG) levels have been used as a biomarker for the diagnosis and treatment response monitoring in airway allergic diseases such as allergic bronchopulmonary aspergillosis and allergic fungal rhinosinusitis. However, its role in common primary
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Increased CD123 + HLA-DR− Granulocytes in Allergic Rhinitis and Influence of Allergens on Expression of Cell Membrane Markers Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-05-08 Hua Xie, Huiyun Zhang, Dong Chen, Lei Cheng, Fangqiu Gu, Shunlan Wang, Meicen Liu, Li Li, Qingwei Zeng, Shaoheng He
BackgroundIt is reported that CD123 + HLA-DR- cells in PBMC are basophils, and CD203c, CD63, and FcεRI molecules are activation markers of basophils. However, little is known of CD123 + HLA-DR-cells in blood granulocytes.ObjectiveTo investigate the presence of CD123 + HLA-DR- cells in the blood granulocytes and peripheral PBMC of patients with allergic rhinitis (AR), as well as the impact of allergens
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Predictive Value of Nasal Nitric Oxide for Diagnosing Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-29 Do Hyun Kim, Hyesoo Shin, Gulnaz Stybayeva, Se Hwan Hwang
ObjectivesThe primary aim of this study was to assess disparities in nasal nitric oxide (NO) levels between individuals diagnosed with eosinophilic chronic rhinosinusitis (ECRS) and those without ECRS. The second aim was to ascertain the comparative predictive efficacy of these nasal NO levels for the presence of ECRS.MethodsA systematic analysis was conducted on relevant studies that compared nasal
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Predictors of Subjective Olfactory Dysfunction and Sinonasal Quality-of-Life After Endoscopic Transsphenoidal Pituitary Surgery Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-22 Bita R. Naimi, Douglas Farquhar, Alexander N. Duffy, Emily A. Garvey, Patrick Kelly, Chase Kahn, Riyana Doshi, Riya Shah, Mindy R. Rabinowitz, Elina Toskala, Marc Rosen, James J. Evans, Gurston G. Nyquist
BackgroundThis is the largest study in North America investigating olfactory outcomes after pituitary surgery to date.ObjectiveCharacterize factors associated with subjective olfactory dysfunction (OD) and worsened sinonasal quality-of-life (QOL) after endoscopic TSA.MethodsPatients undergoing primary TSA for secreting and non-secreting pituitary adenomas between 2017 and 2021 with pre- and post-operative
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Posterior Nasal Nerve Ablation as a Viable Treatment Option for the Primary Symptom of Postnasal Drip Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-18 Aatin K. Dhanda, Daniel Gorelik, Najm Khan, Masayoshi Takashima, Patrick Bishara, Edward D. McCoul, Aria Jafari, Omar G. Ahmed
BackgroundPostnasal drip (PND) syndrome is a prevalent complaint encountered in otolaryngology practices. PND may be refractory to medical therapy, and surgical treatments are complicated by side effects.ObjectiveWhile posterior nasal nerve (PNN) ablation has demonstrated efficacy for chronic rhinitis overall, we sought to examine the effect of PNN ablation for patients with PND as their primary complaint
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A New Patient-reported Outcomes Measure for Surgically Treated Epiphora: Tearing Assessment and Rating Scale-12 (TEARS-12) Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-16 Aria Jafari, Jonathan C. Simmonds, Margaret B. Mitchell, Catherine G. Banks, Ashton Lehmann, Marianella Paz-Lansberg, Michael K. Yoon, Ralph Metson
BackgroundNo widely accepted, validated instrument currently exists to measure clinical outcomes in patients who undergo dacryocystorhinostomy (DCR) for treatment of epiphora.ObjectiveTo develop a patient-reported outcome measure applicable to this population.MethodsPsychometric evaluations, consultation with experts, and review of the literature informed item generation of a 12-question questionnaire
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The Role of Inhalant Allergens on the Clinical Manifestations of Atopic Dermatitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-16 Jaekeun Jung, Clinton W. Enos, Kent K. Lam, Joseph K. Han
BackgroundInhalant allergens provide a source of environmental factors that contribute to the development of clinical symptoms in patients with atopic dermatitis (AD).ObjectiveTo review the relationship between inhalant allergens and AD.MethodsA literature review was conducted using three databases: PubMed/MEDLINE, ClinicalKey, and Web of Science. Search terms, including “atopic dermatitis,” “atopic
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The Impact of Acute Peri-operative Particulate Matter Exposure on Endoscopic Sinus Surgery Outcomes: A Preliminary Multi-site Investigation Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-16 Benton Tullis, Jess C. Mace, Robert Hagedorn, Cassidy Nguyen, Ryan Stockard, Conner Massey, Vijay R. Ramakrishnan, Daniel M. Beswick, Zachary M. Soler, Timothy L. Smith, Jeremiah A. Alt, Amarbir S. Gill
BackgroundEnvironmental exposures have been postulated to play an important role in the pathophysiology of chronic rhinosinusitis (CRS). Particulate matter (PM) is one of the most widely studied ambient air pollutants, but its peri-operative impact on CRS is unknown.ObjectiveTo determine the effect of acute, peri-operative PM exposure on outcomes after endoscopic sinus surgery (ESS).MethodsParticipants
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Medical Literature: Discovery, Education, and Advancement Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-08 Steven D. Pletcher
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Practice Patterns Among Fellowship-Trained Rhinologists: A Survey of Past American Rhinologic Society Fellows Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-04-08 Dennis M. Tang, Tasha S. Nasrollahi, Missael Vasquez, Michela Borrelli, Raj Sindwani, Arthur W. Wu
BackgroundThe goals of this study were to understand the trends in recent and past rhinology fellows concerning their demographics, goals, and experiences.MethodsAn anonymous web-based survey was sent to graduates of the 35 rhinology fellowship programs. The survey included questions regarding the scope of practice, research contribution, societal involvement, fellow satisfaction with training, and
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Effects of Endoscopic Sinus Surgery on Olfactory Bulb Volume among Patients with Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-29 Xincen Jiang, Tianhao Huang, Feifan Chang, Yu Song, Dawei Wu
BackgroundEndoscopic sinus surgery (ESS) could significantly improve olfactory function among patients with chronic rhinosinusitis (CRS). This study aimed to perform a meta-analysis to evaluate the effect of ESS on the olfactory bulb volume (OBV) among patients with CRS.MethodsA systemic search of PubMed, Medline, Embase, Web of Science, and other databases was conducted to identify studies assessing
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Multi-Institutional Analysis of Insurance Denial Patterns Within Rhinology Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-28 Tyler A. Janz, Najm S. Khan, Aatin K. Dhanda, Masayoshi Takashima, Arthur W. Wu, Dennis M. Tang, Thomas S. Higgins, Murugappan Ramanathan, Omar G. Ahmed
BackgroundObtaining insurance approval is a necessary component of healthcare in the United States and denials of these claims have been estimated to result in a loss of 3% to 5% of revenue.ObjectiveExamine the trends in insurance denials for rhinological procedures.MethodsA retrospective review of deidentified financial data of patients who were treated by participating physicians across 3 institutions
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The Time Burden of Office Visits in Contemporary Pituitary Care, 2016 to 2019 Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-28 Rose C. Dimitroyannis, Thomas F. Cyberski, Neil S. Kondamuri, Sean P. Polster, Paramita Das, Peleg M. Horowitz, Christopher R. Roxbury
BackgroundThe concept of “time toxicity” has emerged to address the impact of time spent in the healthcare system; however, little work has examined the phenomenon in the field of otolaryngology.ObjectiveTo validate the use of Evaluation and Management (E/M) current procedural terminology codes as a method to assess time burden and to pilot this tool to characterize the time toxicity of office visits
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Thoughts on the Surprising Effect of Priming on 22-Item Sino-Nasal Outcome Test (SNOT-22) Results Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-20 Nathan Yang, Adam Waytz, Zachary M. Soler, Jonathan B. Overdevest, David A. Gudis
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Head-Down Topical Sinus Rinses: Cut Your Way to Success Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-11 Arthur William Wu, Dennis Mansfield Tang, Gene C. Liu
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Quantification of Budesonide Retained in the Sinonasal Cavity After High-Volume Saline Irrigation in Post-Operative Chronic Rhinosinusitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-08 Paige A. Shipman, Bhuvanesh Yathavan, Amarbir S. Gill, Chelsea E. Pollard, Venkata Yelleppedi, Hamidreza Ghandehari, Jeremiah A. Alt, Abigail Pulsipher, Kristine A. Smith
BackgroundBudesonide high-volume saline irrigations (HVSIs) are routinely used to treat chronic rhinosinusitis (CRS) due to improved sinonasal delivery and efficacy compared to intranasal corticosteroid sprays. The off-label use of budesonide is assumed to be safe, with several studies suggesting the systemically absorbed dose of budesonide HVSI is low. However, the actual budesonide dose retained
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Biofilm-producing Bacteria and Quality of Life after Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyposis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-08 Jovica Milovanović, Dragana D. Božić, Bojan Pavlović, Ana Jotić, Snežana Brkić, Ivana Ćirković
BackgroundChronic rhinosinusitis (CRS) is one of the most common health disorders in humans and has a major impact on health-related quality of life (HRQoL). Of the many factors contributing to the etiology of CRS, less is known about the correlation between CRS and bacterial biofilms and their impact on HRQoL.ObjectiveThe aim of this prospective study was to investigate the relationship between biofilm-producing
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Endoscopic and Radiologic Central Compartment Disease as Predictors of Perennial Inhalant Allergen Sensitization in Chronic Rhinosinusitis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-06 Linus Lau, Terese Low, Yew Kwang Ong, Xu Xinni
BackgroundCentral compartment atopic disease (CCAD) is a recently described variant of chronic rhinosinusitis (CRS) strongly associated with atopy. The association between central compartment disease (CCD) and inhalant allergy is not well established in South-East Asia, where perennial allergic rhinitis is common.ObjectivesThe primary objective was to evaluate endoscopic and radiologic CCD as predictors
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Early Endonasal Dacryocystorhinostomy for Acute Dacryocystitis: A Systematic Review and Meta-Analysis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-03-06 Jia Li, Jihong Wang, Changling Sun
ObjectiveThe aim of this meta-analysis is to compare the outcomes of early endonasal dacryocystorhinostomy (DCR) with delayed DCR in the treatment of acute dacryocystitis (AD).MethodsA comprehensive electronic search of PubMed, Embase, Web of Science, and the Cochrane Library databases was conducted up to November 11, 2023. Data synthesis was performed using Review Manager 5.4, and forest plots were
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Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients’ nasal mucosa Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-02-20 Wei Zhao, Yunfang An, Fengli Cheng, Changqing Zhao
BackgroundThe neuropeptide U (NMU) has been proven to elicit the release of mediators from mast cells (MCs) through its receptor NMUR1 in allergic inflammatory models. However, little is known about the correlations between NMU and MCs in human allergic rhinitis (AR).ObjectiveThe objective of this study is to investigate the expressions of NMU and NMUR1 in the tryptase + MCs and the peripheral blood
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The Surprising Effect of Priming on SNOT-22 Results Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-02-09 Ibtisam Mohammad, Taylor Stack, Meghan Norris, Sulgi Kim, Meredith Lamb, Brian D. Thorp, Christine Klatt-Cromwell, Charles S. Ebert, Adam J. Kimple, Brent A. Senior
BackgroundPriming is a psychological phenomenon where subconscious cues in the environment impact our behavioral responses in certain situations. Well studied in the worlds of business, marketing, and even politics, it is unclear how the priming phenomenon impacts patient perception of their own disease state nor how they report that perception using tools like the Sinonasal Outcomes Test (SNOT-22)
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Higher Risk of Rheumatoid Arthritis in Patients With Chronic Rhinosinusitis: Prospective Association in the U.K. Biobank and Genetic Evidence by Mendelian Randomization Analysis Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-01-16 Yimin Dong, Weizhong Ding, Kehan Song, Feng Li
BackgroundPrevious studies have shown that respiratory diseases are associated with an increased risk of rheumatoid arthritis (RA). However, whether there is a correlation between chronic rhinosinusitis (CRS) and RA is not known. Due to the high incidence of CRS, it remains to be clarified whether we should pay additional attention to RA risk in the huge population of CRS.MethodsWe used a 2-sample
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MicroRNA-125b Is a Potential Predictor of Surgical Outcomes in Chronic Rhinosinusitis with Nasal Polyps Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-01-09 Anda Gata, Daniel-Corneliu Leucuta, Liviuta Budisan, Lajos Raduly, Veronica E. Trombitas, Ioana Berindan-Neagoe, Silviu Albu
BackgroundDespite advances in surgical techniques, recurrence rates after endoscopic sinus surgery (ESS) for chronic rhinosinusitis with nasal polyps (CRSwNP) remain high and difficult to predict.ObjectiveThis study aimed to evaluate the potential role of microRNA 125b (miR-125b) in predicting disease evolution following ESS.MethodsWe conducted a prospective study including patients undergoing first
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Treatment, Management, and Otolaryngology Consultation for Epistaxis in the Emergency Room: An Institutional Experience. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-12-28 Daniel Jacobs,Vickie J Wang,Janet R Chao,R Peter Manes,Yan H Lee
BACKGROUND Epistaxis is a common reason for emergency department (ED) visits, accounting for approximately 1 of every 200 ED visits in the United States annually and up to one-third of all otolaryngology (ENT)-related ED encounters. OBJECTIVES To detail reasons for ENT consultation for epistaxis in the ED, understand how consultation impacts patient care, assess follow-up patterns after emergency care
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The Efficacy of Sodium Phytate as a Natural Chelating Agent in Reducing Elevated Calcium Levels in Nasal Mucus Among Individuals Experiencing Olfactory Dysfunction Following COVID-19: A Prospective Randomized Double-Controlled Clinical Trial. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-12-17 Abdullah H Altemani,Mansuor A Alanazi,Assem H Altemani,Adnan Alharbi,Saud Alsahali,Nawaf M Alotaib,Mohamed H Abdelazim
BACKGROUND COVID-19 has been associated with olfactory disturbances in many infected patients. The increase in calcium levels in nasal secretions plays an essential role in the olfactory process with a desensitizing effect on olfactory receptor neurons and negative effects on odor transmission. Calcium chelating agents have the ability to bind calcium in nasal mucus and prevent the negative effects
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Genetic Association of Allergic Rhinitis with Sleep and Neuropsychological Disorders: A Mendelian Randomization Study. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-12-13 Chenxi Lin,Jia Li,Ye Deng,Xiongwen Li,Xiaofeng Wang,Jingcheng Lu
BACKGROUND The genetic association of allergic rhinitis (AR) with other physiological systems throughout the human body remains unknown. OBJECTIVE The aim of this Mendelian randomization (MR) study was to explore the association of this respiratory disorder with multiple common sleep and neuropsychological disorders at the genetic level. METHODS Summary data for total AR and pollen AR were collected
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You Do Not Rise to the Level of Your Goals; You Fall to the Level of Your Systems. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2024-01-01 Ralph Abi Hachem
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Validation of Minimal Clinically Important Difference (MCID) for University of Pennsylvania Smell Identification Test (UPSIT). Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-12-06 Ashna Mahadev,Dorina Kallogjeri,Jay F Piccirillo
BACKGROUND The University of Pennsylvania Smell Identification Test is widely used to measure change in olfactory function, but a minimal clinically important difference (MCID) has not been well-established. A study published in 1997 regarding patients with head trauma reported an MCID of 4 but did not detail the methods used in the calculation. OBJECTIVE To validate the MCID for UPSIT in patients
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The Effect of Rosmarinic Acid on Wound Healing of Nasal Mucosa in the Rats. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-11-22 Arzu Erdal,Doğukan Özdemir,Şule Özdemir,Mustafa Bakırtaş,İbrahim Ağrı
BACKGROUND The nose can be damaged by environmental pollutants and foreign bodies, as well as a result of trauma, infection or surgical interventions. Proper healing of the damaged nasal mucosa is important for health. OBJECTIVE There is no study in the literature investigating the effects of rosmarinic acid on mucosal healing. The aim of this study was to investigate the effect of rosmarinic acid
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The Impact of the Nasal Mucosal Flap on Tissue Remodeling After Sinus Bone Drilling in Rabbit Models. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-11-07 Cao Lv,Cheng Li,Jing Qu,Yi Dong,Zhenxiao Huang,Yan Sun,Shunjiu Cui,Qian Huang,Bin Wang,Mingrui Huo,Bing Zhou
BACKGROUND Frontal sinus surgery remained a challenge of restenosis or obliteration of the drainage pathway caused by the scarring and neo-osteogenesis after mucosal stripping and bone drill-out. The pedicled or free nasal mucosal flap is typically used to repair the exposed bone surface to avoid or reduce recurrence. OBJECTIVE This study aimed to explore the histopathological mechanism of mucosal
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"You are Always a Student, Never a Master: You Have to Keep Moving Forward" Conrad Hall. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-11-01 Anthony Del Signore
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Association Between Chronic Rhinosinusitis and Reflux Diseases in Adults: A Systematic Review and Meta-Analysis. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-10-31 Ahmad Aldajani,Fahad Alhussain,Tamer Mesallam,Mashal AbaAlkhail,Raed Alojayri,Hashem Bassam,Omar Alotaibi,Mohammed Alqahtani,Saad Alsaleh
BACKGROUND Over the last few decades, reflux diseases, such as laryngopharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD), have been identified as significant contributors to inflammatory upper aerodigestive tract diseases. Establishing a direct relationship between reflux disease and chronic rhinosinusitis (CRS) is challenging due to the high prevalence of both diseases and their potential
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Health-Related Quality of Life Outcome Measures in Individuals With Hereditary Hemorrhagic Telangiectasia: A Scoping Review. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-10-19 Anna J Gong,Tushar Garg,Adham Khalil,Prateek C Gowda,Stephen C Mathai,Nicholas R Rowan,Christian A Merlo,Clifford R Weiss
BACKGROUND Studies evaluating health-related quality of life (HRQOL) in patients with hereditary hemorrhagic telangiectasia (HHT) have expanded rapidly in the past decade. These studies have evaluated QOL aspects ranging from the general QOL for patients living with HHT to intervention-specific outcomes. However, few tools have been fully validated across the spectrum of disease manifestations and
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Assessing the Psychometric Validity of the Epistaxis Severity Score: Internal Consistency and Test-Retest Reliability. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-10-11 Anna J Gong,Marisabel Linares Bolsegui,Emerson E Lee,Stephen C Mathai,Clifford R Weiss
BACKGROUND The Epistaxis Severity Score (ESS) is the gold-standard patient-reported outcome measure for evaluating nosebleed severity in patients with hereditary hemorrhagic telangiectasia (HHT). To date, the ESS has been assessed only for content validity and concurrent validity. OBJECTIVE We evaluate the internal consistency and test-retest reliability of the ESS. MATERIALS AND METHODS After receiving
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Association Between Immune-Related Disease and Allergic Rhinitis: A Two-Sample Mendelian Randomization Study. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-10-11 Jinming Zhao,Mengmeng Zhang,Zufei Li
BACKGROUND Immune-related diseases can interact with each other, and growing evidence suggests that these diseases are associated with allergic rhinitis (AR). However, it is unclear whether previously observed associations reflect causal relationships. OBJECTIVE This study estimated the genetic association between various immune-related diseases and AR using two-sample Mendelian randomization (MR)
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Race and Area of Deprivation Index Predict Outcomes of Endoscopic Sinus Surgery for Chronic Sinusitis. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-10-05 Firas Hentati,Jaehee Kim,David Hoying,Brian D'Anza,Kenneth Rodriguez
OBJECTIVE The purpose of this study is to characterize the presentation, outcomes, and barriers to care for White and non-White patients undergoing endoscopic sinus surgery (ESS). BACKGROUND ESS is often successful in providing long-term relief for patients suffering from chronic rhinosinusitis (CRS). Literature that uses robust measures of socioeconomic status (SES) and barriers to care to assess
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Long-Term Efficacy of Dupilumab for Eosinophilic Chronic Rhinosinusitis. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-09-26 Yasuhiro Tsunemi,Tsuguhisa Nakayama,Takashi Kashiwagi,Makoto Akutsu,Shota Saito,Shinichi Haruna
BACKGROUND Eosinophilic chronic rhinosinusitis (eCRS) is a type 2 inflammatory disease that frequently recurs after surgery. In recent years, dupilumab has been available for the treatment of refractory chronic rhinosinusitis since 2020 in Japan. Although there are some reports of its usefulness, there are not enough reports of its clinical efficacy for longer than 1 year, especially for olfactory
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Bringing Together Multiple Perspectives in Rhinology and Allergy. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-09-01 Sarita U Patil
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Eustachian Tube Balloon Dilation: A Comprehensive Analysis of Adverse Events. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-08-27 Tyler B Merrill,Vijay A Patel,Christopher Pool,John L Dornhoffer,Robert A Saadi
BACKGROUND Eustachian tube balloon dilation (ETBD) has been Food and Drug Administration (FDA) approved for refractory Eustachian tube dysfunction since 2016. While ETBD is generally seen as safe, the complication profile has not been well defined. OBJECTIVE The objective of this study was to utilize the FDA manufacturer and user facility device experience (MAUDE) database to better assess adverse
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Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-08-16 Tripti Brar,Saurabh Baheti,Michael J Marino,Hirohito Kita,Devyani Lal
BACKGROUND Epigenetics studies mechanisms such as DNA methylation, histone modifications, non-coding RNAs, and alternative polyadenylation that can modify gene activity without changing the underlying DNA nucleotide base-pair structure. Because these changes are reversible, they have potential in developing novel therapeutics. Currently, seven pharmaceutical agents targeting epigenetic changes are
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Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients with Asthma: A Systematic Review and Meta-Analysis. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-08-09 Dijiang Ma,Qiling Zheng,Jianing Sun,Shenjun Tang,Wudan He
OBJECTIVE Sublingual immunotherapy (SLIT) has been widely applied to treat patients with allergic rhinitis (AR). However, meta-analyses on the efficacy of SLIT in AR patients with asthma are still limited. METHODS Literature without language limitation published before October 28, 2022, were retrieved from PubMed, EMBASE, and Cochrane Library. STATA 16.0 software was used for the meta-analysis of the
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Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population. Am. J. Rhinol. Allergy (IF 2.5) Pub Date : 2023-08-08 Xu Liang,Peng Jin,Changcui Zhan,Li Zhao,Xiaoxue Zi,Lili Zhi,Kena Yu
BACKGROUND Evidence has shown that glucocorticoid-induced transcript 1 (GLCCI1) single nucleotide polymorphism (SNP) rs37937 is associated with asthma. OBJECTIVES The objective of this study was to investigate whether the GLCCI1 SNP rs37937 is a risk factor for allergic rhinitis (AR) in a Chinese Han population. METHODS A total of 220 individuals including 109 AR patients and 111 healthy subjects were