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Mechanism of norcantharidin intervention in gastric cancer: analysis based on antitumor proprietary Chinese medicine database, network pharmacology, and transcriptomics Chin. Med. (IF 5.3) Pub Date : 2024-09-17 Yiyan Zhai, Fanqin Zhang, Jiying Zhou, Chuanqi Qiao, Zhengsen Jin, Jingyuan Zhang, Chao Wu, Rui Shi, Jiaqi Huang, Yifei Gao, Siyu Guo, Haojia Wang, Keyan Chai, Xiaomeng Zhang, Tieshan Wang, Xiaoguang Sheng, Xinkui Liu, Jiarui Wu
Combining antitumor proprietary Chinese medicine (pCm) with radiotherapy and chemotherapy can effectively improve tumor cure rates and enhance patients’ quality of life. Gastric cancer (GC) severely endangers public health. Despite satisfactory therapeutic effects achieved by using antitumor pCm to treat GC, its underlying mechanism remains unclear. To integrate existing research data, construct a
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The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation Chin. Med. (IF 5.3) Pub Date : 2024-09-16 Zebiao Cao, Xianzhe Wang, Zhili Zeng, Zhaojun Yang, Yuping Lin, Lu Sun, Qiyun Lu, Guanjie Fan
Modified Si-Miao granule (mSMG), a traditional Chinese medicine, is beneficial for T2DM and insulin resistance (IR), but the underlying mechanism remains unknown. Using network pharmacology, we screened the compounds of mSMG and identified its targets and pathway on hepatic IR in T2DM. Using molecular docking, we identified the affinity between the compounds and hub target TNF-α. Then these were verified
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Machine learning-assisted rapid determination for traditional Chinese Medicine Constitution Chin. Med. (IF 5.3) Pub Date : 2024-09-15 Wen Sun, Minghua Bai, Ji Wang, Bei Wang, Yixing Liu, Qi Wang, Dongran Han
The aim of this study was to develop a machine learning-assisted rapid determination methodology for traditional Chinese Medicine Constitution. Based on the Constitution in Chinese Medicine Questionnaire (CCMQ), the most applied diagnostic instrument for assessing individuals’ constitutions, we employed automated supervised machine learning algorithms (i.e., Tree-based Pipeline Optimization Tool; TPOT)
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Buqi-Huoxue-Tongnao decoction drives gut microbiota-derived indole lactic acid to attenuate ischemic stroke via the gut-brain axis Chin. Med. (IF 5.3) Pub Date : 2024-09-15 Yarui Liu, Peng Zhao, Zheng Cai, Peishi He, Jiahan Wang, Haoqing He, Zhibo Zhu, Xiaowen Guo, Ke Ma, Kang Peng, Jie Zhao
Ischemic stroke belongs to “apoplexy” and its pathogenesis is characterized by qi deficiency and blood stasis combining with phlegm-damp clouding orifices. Buqi-Huoxue-Tongnao decoction (BHTD) is a traditional Chinese medicine formula for qi deficiency, blood stasis and phlegm obstruction syndrome. However, its efficacy and potential mechanism on ischemic stroke are still unclear. This study aims to
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DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk Chin. Med. (IF 5.3) Pub Date : 2024-09-12 Jianmei Shi, Yuxiang Wang, Tao Liang, Xixi Wang, Jingxiao Xie, Renbin Huang, Xiaohui Xu, Xiaojie Wei
Studies have shown that Averrhoa carambola L. possesses therapeutic potential for diabetes and related complications. However, the specific beneficial effects and molecular mechanisms of 2-dodecyl-6-meth-oxycyclohexa-2,5-diene-1,4-dione (DMDD) isolated from Averrhoa carambola L. on diabetic nephropathy (DN) require further investigation. 80 C57BL/6 J male mice were subjected to a 1-week adaptive feeding
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Calculating the similarity between prescriptions to find their new indications based on graph neural network Chin. Med. (IF 5.3) Pub Date : 2024-09-11 Xingxing Han, Xiaoxia Xie, Ranran Zhao, Yu Li, Pengzhen Ma, Huan Li, Fengming Chen, Yufeng Zhao, Zhishu Tang
Drug repositioning has the potential to reduce costs and accelerate the rate of drug development, with highly promising applications. Currently, the development of artificial intelligence has provided the field with fast and efficient computing power. Nevertheless, the repositioning of traditional Chinese medicine (TCM) is still in its infancy, and the establishment of a reasonable and effective research
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Application of omics technologies in studies on antitumor effects of Traditional Chinese Medicine Chin. Med. (IF 5.3) Pub Date : 2024-09-09 Peng Tan, Xuejiao Wei, Huiming Huang, Fei Wang, Zhuguo Wang, Jinxin Xie, Longyan Wang, Dongxiao Liu, Zhongdong Hu
Traditional Chinese medicine (TCM) is considered to be one of the most comprehensive and influential form of traditional medicine. It plays an important role in clinical treatment and adjuvant therapy for cancer. However, the complex composition of TCM presents challenges to the comprehensive and systematic understanding of its antitumor mechanisms, which hinders further development of TCM with antitumor
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Screening of herbal extracts binding with vascular endothelial growth factor by applying HerboChip platform Chin. Med. (IF 5.3) Pub Date : 2024-09-09 Yang Liu, Jia-Ming Liang, Guo-Xia Guo, Yu-Huan Qiu, Le-Le Yu, Karl Wah-Keung Tsim, Qi-Wei Qin, Gallant Kar-Lun Chan, Wei-Hui Hu
Traditional Chinese medicine (TCM) has been hailed as a rich source of medicine, but many types of herbs and their functions still need to be rapidly discovered and elucidated. HerboChip, a target-based drug screening platform, is an array of different fractions deriving from herbal extracts. This study was designed to identify effective components from TCM that interact with vascular endothelial growth
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Uncover the anticancer potential of lycorine Chin. Med. (IF 5.3) Pub Date : 2024-09-08 Yan-Ming Zhang, Ting Li, Chun-Cao Xu, Jia-Yu Qian, Hongwei Guo, Xiaolei Zhang, Zha-Jun Zhan, Jin-Jian Lu
Natural products have a long history in drug discovery. Lycorine is an alkaloid derived from Amaryllidaceae plants, demonstrating significant pharmacological potential. Lycorine and its hydrochloride salt, lycorine hydrochloride, have shown outstanding anticancer effects both in vitro and in vivo. This review aims to comprehensively summarize recent research advancements regarding the anticancer potential
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Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases Chin. Med. (IF 5.3) Pub Date : 2024-09-04 Xinyue Jiang, Hongzhan Wang, Kexin Nie, Yang Gao, Shen Chen, Yueheng Tang, Zhi Wang, Hao Su, Hui Dong
Lipid droplet (LD) is a metabolically active organelle, which changes dynamically with the metabolic state and energy requirements of cells. Proteins that either insert into the LD phospholipid monolayer or are present in the cytoplasm, playing a crucial role in lipid homeostasis and signaling regulation, are known as LD-associated proteins. The keywords “lipid droplets” and “metabolic diseases” were
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Astragali radix (Huangqi): a time-honored nourishing herbal medicine Chin. Med. (IF 5.3) Pub Date : 2024-08-30 Yuyu Zhang, Zhejie Chen, Liping Chen, Qin Dong, Dong-Hua Yang, Qi Zhang, Jing Zeng, Yang Wang, Xiao Liu, Yuan Cui, Minglong Li, Xiao Luo, Chongjian Zhou, Mingzhu Ye, Ling Li, Yuxin He
Astragali radix (AR, namded Huangqi in Chinese) is the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. As a widely used ethnomedicine, the biological activities of AR include immunomodulatory, anti-hyperglycemic, anti-oxidant, anti-aging, anti-inflammatory, anti-viral, anti-tumor, cardioprotective, and anti-diabetic effects
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Britannilactone 1-O-acetate induced ubiquitination of NLRP3 inflammasome through TRIM31 as a protective mechanism against reflux esophagitis-induced esophageal injury Chin. Med. (IF 5.3) Pub Date : 2024-08-30 Ju Liu, Yang Xiao, Qianfei Xu, Yunyan Xu, Manman Guo, Yun Hu, Yan Wang, Yi Wang
Reflux esophagitis (RE) is a disease in which inflammation of the esophageal mucosa owing to the reflux of gastric contents into the esophagus results in cytokine damage. Britannilactone 1-O-acetate (Brt) has anti-inflammatory effects, significantly inhibiting the activation of the NLRP3 inflammasome, leading to a decrease in inflammatory factors including IL-1 β, IL-6, and TNF-α. However, the mechanism
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Exploring the immunometabolic potential of Danggui Buxue Decoction for the treatment of IBD-related colorectal cancer Chin. Med. (IF 5.3) Pub Date : 2024-08-29 Yang Zhang, Qianming Kang, Luying He, Ka Iong Chan, Hui Gu, Wenjing Xue, Zhangfeng Zhong, Wen Tan
Danggui Buxue (DGBX) decoction is a classical prescription composed of Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), used to enrich blood, and nourish Qi in Chinese medicine, with the potential to recover energy and stimulate metabolism. Chronic inflammation is a risk factor in the development of inflammatory bowel disease (IBD)-related colorectal cancer (CRC). More importantly, AR and ASR
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Correction: Cucurbitacin B inhibits TGF-β1-induced epithelial–mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways Chin. Med. (IF 5.3) Pub Date : 2024-08-29 Renyikun Yuan, Qiumei Fan, Xiaowei Liang, Shan Han, Jia He, Qin-Qin Wang, Hongwei Gao, Yulin Feng, Shilin Yang
Correction: Chinese Medicine (2022) 17:24 https://doi.org/10.1186/s13020-022-00581-z Following publication of the original article [1], the authors reported errors in the Western blot results concerning p-AKT (Fig. 4a). To rectify this, they have amended the western blot binds of p-Akt with the original data (Fig. 4a) and the corresponding statistic results (Fig. 4c) in Fig. 4. Additionally, a correction
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Correction: Bridging cultures: Chinese elements in scientific illustrations Chin. Med. (IF 5.3) Pub Date : 2024-08-29 Jianyou Gu, Wenying Zhang, Xianxing Wang, Qiang Zhou, Junfeng Zhang, Fuming Xie, Renpei Xia, Zhe-Sheng Chen, Huaizhi Wang
Correction: Chinese Medicine (2024) 19:103 https://doi.org/10.1186/s13020-024-00972-4 Following publication of the original article [1], the authors reported that the corresponding author Zhe-Sheng Chen was not marked, and the corresponding author information was missing. The correct author information has been provided in this Correction. The original article [1] has been corrected. Gu J, Zhang W
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Comprehensive biomarker analysis of metabolomics in different syndromes in traditional Chinese medical for prediabetes mellitus Chin. Med. (IF 5.3) Pub Date : 2024-08-25 Qin Lan, Xue Li, Jianhe Fang, Xinyu Yu, Zhanxuan E. Wu, Caiyun Yang, Hui Jian, Fei Li
Prediabetes mellitus (PreDM) is a high-risk state for developing type 2 diabetes mellitus (T2DM) and often goes undiagnosed, which is closely associated with obesity and characterized by insulin resistance that urgently needs to be treated. To obtain a better understanding of the biological processes associated with both "spleen-dampness" syndrome individuals and those with dysglycaemic control at
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Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway Chin. Med. (IF 5.3) Pub Date : 2024-08-24 Lu shan, Yijun Chen, Guo An, Xiaoyu Tao, Chuanqi Qiao, Meilin Chen, Jiaqi Li, Ruichao Lin, Jiarui Wu, Chongjun Zhao
Studies have reported that polyphyllin I (PPI) had effective anti-tumor activity against hepatocellular carcinoma (HCC). However, the precise molecular mechanism of this action and the direct target remain unclear. The aim of this study was to discover the molecular targets and the exact mechanism of PPI in the treatment of HCC. Various HCC cells and Zebrafish xenotransplantation models were used to
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Dipeptide PA3264 derived from rare and endangered Squama Manis is a novel bioactive peptide for the treatment of triple-negative breast cancer Chin. Med. (IF 5.3) Pub Date : 2024-08-21 Xiaorong Hou, Zhaofang Bai, Yuanyuan Chen, Wei Shi, Huijie Yang, Ruisheng Li, Xiaoyan Zhan, Youping Liu, Xu Zhao, Xiaohe Xiao
Squama Manis is a valuable traditional Chinese medicine with a long history of medicinal use in the treatment of breast-related diseases. However, owing to the excessive exploitation and utilization of the resources, Squama Manis has been included in the list of rare and endangered wild animals. The conservation of the resources of Squama Manis and continuing its clinical application has become an
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Geniposide for treating atherosclerotic cardiovascular disease: a systematic review on its biological characteristics, pharmacology, pharmacokinetics, and toxicology Chin. Med. (IF 5.3) Pub Date : 2024-08-20 Dexiu Li, Xiaoya Li, Xiaonan Zhang, Jiye Chen, Zeping Wang, Zongliang Yu, Min Wu, Longtao Liu
In recent years, the prevalence and fatality rates of atherosclerotic cardiovascular disease have not only shown a consistent rise that cannot be ignored, but have also become a pressing social health problem that requires urgent attention. While interventional surgery and drug therapy offer significant therapeutic results, they often come with common side effects. Geniposide, an active component extracted
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Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance Chin. Med. (IF 5.3) Pub Date : 2024-08-20 Yitian Sun, Qinyi Li, Yufei Huang, Zijing Yang, Guohua Li, Xiaoyu Sun, Xiaoqing Gu, Yunhao Qiao, Qibiao Wu, Tian Xie, Xinbing Sui
Redox imbalance is reported to play a pivotal role in tumorigenesis, cancer development, and drug resistance. Severe oxidative damage is a general consequence of cancer cell responses to treatment and may cause cancer cell death or severe adverse effects. To maintain their longevity, cancer cells can rescue redox balance and enter a state of resistance to anticancer drugs. Therefore, targeting redox
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Buyang Huanwu decoction ameliorates myocardial injury and attenuates platelet activation by regulating the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway Chin. Med. (IF 5.3) Pub Date : 2024-08-19 Jiaming Gao, Hao Guo, Junmei Li, Min Zhan, Yue You, Gaojie Xin, Zixin Liu, Xiaodi Fan, Qinghe Gao, Jianxun Liu, Yehao Zhang, Jianhua Fu
Buyang Huanwu Decoction (BYHWD) is a traditional Chinese medicine to treat the syndrome of qi deficiency and blood stasis. Platelets play an important role in regulating thrombus and inflammation after ischemic injury, studies have shown that BYHWD regulate myocardial fibrosis and exert anti-inflammatory effects through IL-17 and TLR4 pathways, but the mechanism of platelet activation by BYHWD in stable
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Electroacupuncture negatively regulates the Nesfatin-1/ERK/CREB pathway to alleviate HPA axis hyperactivity and anxiety-like behaviors caused by surgical trauma Chin. Med. (IF 5.3) Pub Date : 2024-08-17 Jiayuan Zheng, Yu Wang, Chi Zhang, Anjing Zhang, Yuxiang Zhou, Yunhua Xu, Jin Yu, Zhanzhuang Tian
Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis constitutes a pivotal response by surgical trauma, manifesting as a critical aspect of the acute stress reaction. This hyperactivity resulted in adverse surgical outcomes and is often associated with increased postoperative anxiety. Increased evidence suggests that Nesfatin-1 plays a crucial role in stress responses and stress-related psychiatric
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Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding Chin. Med. (IF 5.3) Pub Date : 2024-08-15 Chengwei Li, Jincai Wen, Xiaoyan Zhan, Wei Shi, Xiu Ye, Qing Yao, Simin Chen, Congyang Zheng, Xianlin Wang, Xinru Wen, Xiaohe Xiao, Yinghao Wang, Zhaofang Bai
An important signaling pathway connecting illness and natural immunity is the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, but aberrant activation of this pathway is associated with the development of autoimmune and inflammatory diseases. Hence, targeted inhibition of the activation of the cGAS-STING pathway is potentially valuable in the treatment of disease. The
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Correction: Neuroprotective effects of Shende’an tablet in the Parkinson’s disease model Chin. Med. (IF 5.3) Pub Date : 2024-08-13 Xiaoyan Sheng, Shuiyuan Yang, Xiaomin Wen, Xin Zhang, Yongfeng Ye, Peng Zhao, Limin Zang, Kang Peng, Enming Du, Sai Li
Correction to: Chin Med (2021) 16:18 https://doi.org/10.1186/s13020-021-00429-y Following publication of the original article [1], the authors reported that there were inaccuracies in the subimages of Figs. 1c, 2a, 3a, and the HO-1 and β-actin protein bands in Fig. 6. They have corrected these errors with the accurate subimages in the correct versions. These corrections do not alter the outcomes or
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Shirebi granules ameliorate acute gouty arthritis by inhibiting NETs-induced imbalance between immunity and inflammation Chin. Med. (IF 5.3) Pub Date : 2024-08-09 Xin Li, Xia Mao, Hong Jiang, Cong Xia, Lu Fu, Wenjing Gao, Wenjia Chen, Weijie Li, Ping Wang, Yanqiong Zhang, Haiyu Xu
Acute gouty arthritis (AGA) is classified as ‘arthritis’ in traditional Chinese medicine (TCM) theory. Shirebi granules (SGs), derived from the classic prescription SiMiaoWan, exerts satisfying therapeutic efficacy in ameliorating AGA clinically. However, the underlying mechanisms of SGs against AGA remain unclarified. AGA-related biological processes, signal pathways and biomarker genes were mined
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The analgesic effects of Yu-Xue-Bi tablet (YXB) on mice with inflammatory pain by regulating LXA4-FPR2-TRPA1 pathway Chin. Med. (IF 5.3) Pub Date : 2024-08-06 Ying Liu, Guoxin Zhang, Chunyan Zhu, Xuemin Yao, Wenli Wang, Li Shen, Haiping Wang, Na Lin
Oxylipins including lipoxin A4 (LXA4) facilitate the resolution of inflammation and possess analgesic properties by inhibiting macrophage infiltration and transient receptor potential (TRP) protein expression. Yu-Xue-Bi Tablet (YXB) is a traditional Chinese patent medicine used to relieve inflammatory pain. Our previous research has shown that the analgesic effect of YXB is related to inhibiting peripheral
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Bridging cultures: Chinese elements in scientific illustrations Chin. Med. (IF 5.3) Pub Date : 2024-07-24 Jianyou Gu, Wenying Zhang, Xianxing Wang, Qiang Zhou, Junfeng Zhang, Fuming Xie, Renpei Xia, Zhe-Sheng Chen, Huaizhi Wang
In the context of globalization, the integration of cultural elements into scientific research, particularly through the incorporation of traditional Chinese cultural motifs in scientific illustrations, represents a novel frontier in enhancing the universality and appeal of scientific discoveries. This paper explores the innovative practice of embedding traditional Chinese cultural elements into scientific
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Biosynthesis and signal transduction of plant growth regulators and their effects on bioactive compound production in Salvia miltiorrhiza (Danshen) Chin. Med. (IF 5.3) Pub Date : 2024-07-24 Heqin Li, Xuwen Jiang, Kiyoshi Mashiguchi, Shinjiro Yamaguchi, Shanfa Lu
Plant growth regulators (PGRs) are involved in multiple aspects of plant life, including plant growth, development, and response to environmental stimuli. They are also vital for the formation of secondary metabolites in various plants. Salvia miltiorrhiza is a famous herbal medicine and has been used commonly for > 2000 years in China, as well as widely used in many other countries. S. miltiorrhiza
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Sound as a bell: a deep learning approach for health status classification through speech acoustic biomarkers Chin. Med. (IF 5.3) Pub Date : 2024-07-24 Yanbing Wang, Haiyan Wang, Zhuoxuan Li, Haoran Zhang, Liwen Yang, Jiarui Li, Zixiang Tang, Shujuan Hou, Qi Wang
Human health is a complex, dynamic concept encompassing a spectrum of states influenced by genetic, environmental, physiological, and psychological factors. Traditional Chinese Medicine categorizes health into nine body constitutional types, each reflecting unique balances or imbalances in vital energies, influencing physical, mental, and emotional states. Advances in machine learning models offer
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Theoretical exploring of potential mechanisms of antithrombotic ingredients in danshen-chishao herb-pair by network pharmacological study, molecular docking and zebrafish models Chin. Med. (IF 5.3) Pub Date : 2024-07-16 Chang Rao, Ruixue Hu, Yongxin Hu, Yan Jiang, Xu Zou, Huilan Tang, Xing Chen, Xiaoli He, Guang Hu
Salvia miltiorrhiza (Danshen, DS) and Radix Paeoniae Rubra (Chishao, CS) herbal pair (DS-CS) is a famous traditional Chinese combination which has been used as antithrombotic formular for centuries. However, there is still lack of sufficient scientific evidence to illustrate its underlying mechanisms. The purpose of this study is to investigate the antithrombotic effects of DS-CS extract in zebrafish
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Deciphering the benefits and intensity levels of primary metabolites from Allium macrostemon Bunge and Allium chinense G. Don Chin. Med. (IF 5.3) Pub Date : 2024-07-15 Zifei Qin, Yuan Li, Dongmei Liu, Yuzhuo Hua, Yuandong Lv, Xiaojian Zhang, Cailian Fan, Jing Yang
Allii Macrostemonis Bulbus is also named Xiebai in China. It is an edible vegetable, and also a famous herb for treating coronary heart disease. Allium chinense G. Don (ACGD) and Allium macrostemon Bunge (AMB) are it botanical sources. The aim of this study was to explore the cardioprotective effects, and decipher the visual spatial distribution and absolute content of primary metabolites derived from
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Santalum album L. alleviates cardiac function injury in heart failure by synergistically inhibiting inflammation, oxidative stress and apoptosis through multiple components Chin. Med. (IF 5.3) Pub Date : 2024-07-15 Bojiao Ding, Li Jiang, Na Zhang, Li Zhou, Huiying Luo, Haiqing Wang, Xuetong Chen, Yuxin Gao, Zezhou Zhao, Chao Wang, Zhenzhong Wang, Zihu Guo, Yonghua Wang
Heart failure (HF) is a complex cardiovascular syndrome with high mortality. Santalum album L. (SAL) is a traditional Chinese medicine broadly applied for various diseases treatment including HF. However, the potential active compounds and molecular mechanisms of SAL in HF treatment are not well understood. The active compounds and possible mechanisms of action of SAL were analyzed and validated by
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Pharmacological activity and clinical application analysis of traditional Chinese medicine ginger from the perspective of one source and multiple substances Chin. Med. (IF 5.3) Pub Date : 2024-07-12 Cheng Zhang, Anyang Rao, Cui Chen, Yuqing Li, Xiuchi Tan, Jiaxin Long, Xinyue Wang, Junjie Cai, Jiquan Huang, Hua Luo, Chuwen Li, Yuanye Dang
All types of ginger have common fundamental components, although they possess distinct strengths and inclinations when it comes to effectiveness and medicinal applications. Fresh ginger possesses the ability to effectively stimulate movement within the body, alleviate the act of vomiting, induce sweating, and provide relief for external syndromes. Dried ginger possesses both defensive and stimulant
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Application of 3D bioprinting technology apply to assessing Dangguiniantongtang (DGNT) decoctions in arthritis Chin. Med. (IF 5.3) Pub Date : 2024-07-08 Zhichao Liang, Yunxi Han, Tao Chen, Jinwu Wang, Kaili Lin, Luying Yuan, Xuefei Li, Hao Xu, Tengteng Wang, Yang Liu, Lianbo Xiao, Qianqian Liang
The aim of this study was to develop a three-dimensional (3D) cell model in order to evaluate the effectiveness of a traditional Chinese medicine decoction in the treatment of arthritis. Chondrocytes (ATDC5) and osteoblasts (MC3T3-E1) were 3D printed separately using methacryloyl gelatin (GelMA) hydrogel bioinks to mimic the natural 3D cell environment. Both cell types showed good biocompatibility
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Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse Chin. Med. (IF 5.3) Pub Date : 2024-07-04 Seungmin Lee, In Gyoung Ju, Hyeyoon Eo, Jin Hee Kim, Yujin Choi, Myung Sook Oh
Alzheimer's disease (AD) is a common type of dementia characterized by amyloid-β (Aβ) accumulation, lysosomal dysfunction, and tau hyperphosphorylation, leading to neurite dystrophy and memory loss. This study aimed to investigate whether Rhei Undulati Rhizoma (RUR), which has been reported to have anti-neuroinflammatory effect, attenuates Aβ-induced memory impairment, neuritic dystrophy, and tau
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An optimal combination of four active components in Huangqin decoction for the synergistic sensitization of irinotecan against colorectal cancer Chin. Med. (IF 5.3) Pub Date : 2024-07-02 Hongyan Zhou, Dingxin Hu, Xian Zhao, Siyuan Qin, Qiyao Nong, Yuan Tian, Zunjian Zhang, Haijuan Dong, Pei Zhang, Fengguo Xu
Irinotecan (CPT-11) is a first-line treatment for advanced colorectal cancer (CRC). Four components (baicalin, baicalein, wogonin, and glycyrrhizic acid) derived from Huangqin Decoction (HQD) have been proven to enhance the anticancer activity of CPT-11 in our previous study. This study aimed to determine the optimal combination of the four components for sensitizing CPT-11 as well as to explore the
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Therapeutic potentials of allicin in cardiovascular disease: advances and future directions Chin. Med. (IF 5.3) Pub Date : 2024-07-02 Yijie Gao, Baofu Wang, Gaofeng Qin, Shichao Liang, Jiajie Yin, Hong Jiang, Mengru Liu, Xianlun Li
Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate)
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G protein-coupled receptors and traditional Chinese medicine: new thinks for the development of traditional Chinese medicine Chin. Med. (IF 5.3) Pub Date : 2024-07-02 Ting Zhang, Wenqiao An, Shengjie You, Shilin Chen, Sanyin Zhang
G protein-coupled receptors (GPCRs) widely exist in vivo and participate in many physiological processes, thus emerging as important targets for drug development. Approximately 30% of the Food and Drug Administration (FDA)-approved drugs target GPCRs. To date, the ‘one disease, one target, one molecule’ strategy no longer meets the demands of drug development. Meanwhile, small-molecule drugs account
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Angelicin improves osteoporosis in ovariectomized rats by reducing ROS production in osteoclasts through regulation of the KAT6A/Nrf2 signalling pathway Chin. Med. (IF 5.3) Pub Date : 2024-07-02 Xiao-feng Liu, Yi-tao Liao, Jia-hao Shao, Dan-dan He, Zhi-hong Fan, Ye-Nan Xu, Chao Li, Xian Zhang
Angelicin, which is found in Psoralea, can help prevent osteoporosis by stopping osteoclast formation, although the precise mechanism remains unclear. We evaluated the effect of angelicin on the oxidative stress level of osteoclasts using ovariectomized osteoporosis model rats and RAW264.7 cells. Changes in the bone mass of the femur were investigated using H&E staining and micro-CT. ROS content was
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Development of an artificial intelligent model for pre-endoscopic screening of precancerous lesions in gastric cancer Chin. Med. (IF 5.3) Pub Date : 2024-06-29 Lan Wang, Qian Zhang, Peng Zhang, Bowen Wu, Jun Chen, Jiamin Gong, Kaiqiang Tang, Shiyu Du, Shao Li
Given the high cost of endoscopy in gastric cancer (GC) screening, there is an urgent need to explore cost-effective methods for the large-scale prediction of precancerous lesions of gastric cancer (PLGC). We aim to construct a hierarchical artificial intelligence-based multimodal non-invasive method for pre-endoscopic risk screening, to provide tailored recommendations for endoscopy. From December
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Phytotherapeutic potential against MRSA: mechanisms, synergy, and therapeutic prospects Chin. Med. (IF 5.3) Pub Date : 2024-06-22 Qiqi He, Julie Meneely, Irene R. Grant, Jason Chin, Séamus Fanning, Chen Situ
Rising resistance to antimicrobials, particularly in the case of methicillin-resistant Staphylococcus aureus (MRSA), represents a formidable global health challenge. Consequently, it is imperative to develop new antimicrobial solutions. This study evaluated 68 Chinese medicinal plants renowned for their historical applications in treating infectious diseases. The antimicrobial efficacy of medicinal
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Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis Chin. Med. (IF 5.3) Pub Date : 2024-06-19 Guiyun Wang, Weixi Xie, Lang Deng, Xiaoting Huang, Mei Sun, Wei Liu, Siyuan Tang
Extended contact with silica particles can lead to Silicosis, a chronic lung condition lacking established treatment protocols or clear mechanisms of development. The urgency for innovative treatments arises from the unavailability of effective treatment methodologies. The origin of silica-induced pulmonary fibrosis includes essential processes such as macrophage activation and the conversion of fibroblasts
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Shaoyao Decoction reduced T lymphocyte activation by regulating of intestinal flora and 5-hydroxytryptamine metabolism in ulcerative colitis Chin. Med. (IF 5.3) Pub Date : 2024-06-15 Jianhua Zhen, Yini Li, Yunan Zhang, Yali Zhou, Lu Zhao, Guangrui Huang, Anlong Xu
Shaoyao Decoction (SYD) is a widely recognized herbal formula utilized in traditional Chinese medicine for the treatment of diarrhea. Although it has demonstrated significant effectiveness in clinical practice for treating ulcerative colitis, the precise mechanisms by which it operates remain largely elusive. The active ingredients of SYD were obtained by ultra performance liquid chromatography tandem
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β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy Chin. Med. (IF 5.3) Pub Date : 2024-06-15 Qiong Zhao, Lu Chen, Xin Zhang, Hua Yang, Yi Li, Ping Li
Resident microglia- and peripheric macrophage-mediated neuroinflammation plays a predominant role in the occurrence and development of ischemic stroke. Microglia undergo polarization to M1/M2-like phenotype under stress stimulation, which mediates intracellular inflammatory response. β-elemene is a natural sesquiterpene and possesses potent anti-inflammatory activity. This study aimed to investigate
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Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity Chin. Med. (IF 5.3) Pub Date : 2024-06-14 Weijie Zhu, Naqi Lian, Jia Wang, Fengming Zhao, Bowen Liu, Jiaxing Sheng, Chenyan Zhang, Xuan Zhou, Wenbai Gao, Chen Xie, Haoyu Gu, Yuxin Zhang, Mianli Bian, Miao Jiang, Yu Li
Liguzinediol (Lig) has emerged as a promising candidate for mitigating Doxorubicin (DOX)-induced cardiotoxicity, a significant limitation in the clinical application of this widely used antineoplastic drug known for its efficacy. This study aimed to explore the effects and potential mechanisms underlying Lig’s protective role against DOX-induced cardiotoxicity. C57BL/6 mice were treated with DOX. Cardiac
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The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system Chin. Med. (IF 5.3) Pub Date : 2024-06-12 Mei Rong, Jiu-Jie Jia, Min-Qiu Lin, Xing-Li-Shang He, Zhi-Yi Xie, Ning Wang, Ze-Hua Zhang, Ying-Jie Dong, Wan-Feng Xu, Jia-Hui Huang, Bo Li, Ning-Hua Jiang, Gui-Yuan Lv, Su-Hong Chen
Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, which render them susceptible to the infiltration of pathogenic factors. LJC, which has a long history in traditional Chinese medicine for nourishing the Yin and blood and calming the mind, is obtained by modifying Qiyuan paste. Dendrobium officinale Kimura et Migo has been shown to improve the
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Zedoary turmeric oil injection ameliorates lung inflammation via platelet factor 4 and regulates gut microbiota disorder in respiratory syncytial virus-infected young mice Chin. Med. (IF 5.3) Pub Date : 2024-06-11 Yu-Zhuo Wu, Qian Zhang, Hua Li, Cheng-Xi Jiang, Xiao-Kun Li, Hong-Cai Shang, Sheng Lin
Respiratory syncytial virus (RSV)-induced lung inflammation is one of the main causes of hospitalization and easily causes disruption of intestinal homeostasis in infants, thereby resulting in a negative impact on their development. However, the current clinical drugs are not satisfactory. Zedoary turmeric oil injection (ZTOI), a patented traditional Chinese medicine (TCM), has been used for clinical
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Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism Chin. Med. (IF 5.3) Pub Date : 2024-06-11 Linjie Pan, Zhanchi Xu, Min Wen, Minghui Li, Dongxin Lyu, Haiming Xiao, Zhuoming Li, Junhui Xiao, Yuanyuan Cheng, Heqing Huang
Heart failure (HF) is characterized by a disorder of cardiomyocyte energy metabolism. Xinbao Pill (XBW), a traditional Chinese medicine formulation integrating “Liushen Pill” and “Shenfu Decoction,” has been approved by China Food and Drug Administration for the treatment of HF for many years. The present study reveals a novel mechanism of XBW in HF through modulation of cardiac energy metabolism.
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Improvement effects of a novel Chinese herbal formula in imiquimod and IL-23-stimulated mouse models of psoriasis Chin. Med. (IF 5.3) Pub Date : 2024-06-11 Lan Wang, Yao-Xing Dou, Qiu-Xia Yu, Zhen Hu, Siu-Po Ip, Yan-Fang Xian, Zhi-Xiu Lin
Psoriasis is a long-term inflammatory skin disease. A novel herbal formula containing nine Chinese herbal medicines, named Inflammation Skin Disease Formula (ISDF), has been prescribed in clinics for decades. To investigate the efficacy and action mechanisms of ISDF on psoriasis using imiquimod (IMQ) and Interleukin-23 (IL-23)-induced models in mice and reveal the pharmacokinetics profile of ISDF in
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Lab-on-a-chip: an advanced technology for the modernization of traditional Chinese medicine Chin. Med. (IF 5.3) Pub Date : 2024-06-09 Zenghui Lu, Yue Yuan, Qiang Han, Yu Wang, Qionglin Liang
Benefiting from the complex system composed of various constituents, medicament portions, species, and places of origin, traditional Chinese medicine (TCM) possesses numerous customizable and adaptable efficacies in clinical practice guided by its theories. However, these unique features are also present challenges in areas such as quality control, screening active ingredients, studying cell and organ
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Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice Chin. Med. (IF 5.3) Pub Date : 2024-06-06 Xiaoyong Xue, Le Wang, Ruiyu Wu, Yufei Li, Runping Liu, Zhi Ma, Kexin Jia, Yinhao Zhang, Xiaojiaoyang Li
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver disease worldwide. Si-Wu-Tang (SWT), a traditional Chinese medicine decoction has shown therapeutic effects on various liver diseases. However, the hepatoprotective effects and underlying mechanism of SWT on MAFLD remain unclear. First, a methionine-choline-deficient (MCD) diet-fed mice model was used and lipidomic
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Saiga antelope horn suppresses febrile seizures in rats by regulating neurotransmitters and the arachidonic acid pathway Chin. Med. (IF 5.3) Pub Date : 2024-06-03 Wenxing Wu, Wencong Song, Jingjing Zhao, Sheng Guo, Min Hong, Jie Zheng, Yongqing Hua, Peng Cao, Rui Liu, Jin-ao Duan
Saiga antelope horn (SAH) is a traditional Chinese medicine for treating febrile seizure (FS) with precise efficacy, but its mechanism of action and functional substances are still unclear. Given the need for further research on SAH, our group conducted studies to elucidate its mechanisms and active substances. An FS rat pup model was constructed through intraperitoneal injection of LPS and hyperthermia
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Traditional Chinese Medicine and renal regeneration: experimental evidence and future perspectives Chin. Med. (IF 5.3) Pub Date : 2024-06-03 Denglu Zhang, Huihui Jiang, Xianzhen Yang, Sanxia Zheng, Yi Li, Shuai Liu, Xiangdong Xu
Repair of acute kidney injury (AKI) is a typical example of renal regeneration. AKI is characterized by tubular cell death, peritubular capillary (PTC) thinning, and immune system activation. After renal tubule injury, resident renal progenitor cells, or renal tubule dedifferentiation, give rise to renal progenitor cells and repair the damaged renal tubule through proliferation and differentiation
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Chrysanthemum morifolium Ramat extract and probiotics combination ameliorates metabolic disorders through regulating gut microbiota and PPARα subcellular localization Chin. Med. (IF 5.3) Pub Date : 2024-06-03 Xinxin Gao, Zhigang Zhu, Yiyang Bao, Yifan Li, Weize Zhu, Xiaofang He, Xinyu Ge, Wenjin Huang, Hao Wang, Wenjing Wei, Jun Du, Liang Chen, Houkai Li, Lili Sheng
Chrysanthemum morifolium Ramat, a traditional Chinese medicine, has the effects on liver clearing, vision improving, and anti-inflammation. C. morifolium and probiotics have been individually studied for their beneficial effects on metabolic diseases. However, the underlying molecular mechanisms were not completely elucidated. This study aims to elucidate the potential molecular mechanisms of C. morifolium
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A simplified herbal decoction attenuates myocardial infarction by regulating macrophage metabolic reprogramming and phenotypic differentiation via modulation of the HIF-1α/PDK1 axis Chin. Med. (IF 5.3) Pub Date : 2024-05-30 Zhi-jun Lin, Xin Dong, Huan He, Jia-lin Jiang, Zhuo-ji Guan, Xuan Li, Lu Lu, Huan Li, Yu-sheng Huang, Shao-xiang Xian, Zhong-qi Yang, Zi-xin Chen, Hong-cheng Fang, Ling-jun Wang
Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and a grim prognosis. A crucial aspect of the inflammatory injury and healing process post-MI involves the dynamic differentiation of macrophages. A promising strategy to alleviate myocardial damage after MI is by modulating the inflammatory response and orchestrating the shift from pro-inflammatory
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Oleanolic acid and its analogues: promising therapeutics for kidney disease Chin. Med. (IF 5.3) Pub Date : 2024-05-30 Dan Pan, Yilun Qu, Chunru Shi, Cheng Xu, Jie Zhang, Hongjian Du, Xiangmei Chen
Kidney diseases pose a significant threat to human health due to their high prevalence and mortality rates. Worryingly, the clinical use of drugs for kidney diseases is associated with more side effects, so more effective and safer treatments are urgently needed. Oleanolic acid (OA) is a common pentacyclic triterpenoid that is widely available in nature and has been shown to have protective effects
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An-Gong-Niu-Huang-Wan (AGNHW) regulates cerebral blood flow by improving hypoperfusion, cerebrovascular reactivity and microcirculation disturbances after stroke Chin. Med. (IF 5.3) Pub Date : 2024-05-22 Xiao Zhang, Jiamin Pei, Luping Xue, Zhe Zhao, Renhao Xu, Cong Zhang, Cong Zhang, Lijie Fu, Xiangjian Zhang, Lili Cui
The restoration of cerebrovascular regulation and improvement of cerebral blood flow in ischaemic regions are crucial for improving the clinical prognosis after stroke. An-Gong-Niu-Huang-Wan (AGNHW) is a famous traditional compound Chinese medicine that has been used for over 220 years to treat acute ischaemic stroke; however, its role in the regulation of cerebral blood flow is still unclear. The
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Natural L-type calcium channels antagonists from Chinese medicine Chin. Med. (IF 5.3) Pub Date : 2024-05-21 Fangfang Xu, Wanna Cai, Bo Liu, Zhenwen Qiu, Xiaoqi Zhang
L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca2+ influx during extracellular excitation. LTCCs are widely present in excitable cells, especially cardiac and cardiovascular smooth muscle cells, and participate in various Ca2+-dependent processes. LTCCs have been considered as worthy drug target for cardiovascular, neurological
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Development of an interpretable machine learning model associated with genetic indicators to identify Yin-deficiency constitution Chin. Med. (IF 5.3) Pub Date : 2024-05-15 Jing Li, Yingying Zhai, Yanqi Cao, Yifan Xia, Ruoxi Yu
Traditional Chinese Medicine (TCM) defines constitutions which are relevant to corresponding diseases among people. As one of the common constitutions, Yin-deficiency constitution influences a number of Chinese population in the disease onset. Therefore, accurate Yin-deficiency constitution identification is significant for disease prevention and treatment. In this study, we collected participants
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Gynostemma Pentaphyllum ameliorates CCl4-induced liver injury via PDK1/Bcl-2 pathway with comprehensive analysis of network pharmacology and transcriptomics Chin. Med. (IF 5.3) Pub Date : 2024-05-15 Linlan Hu, Xin Zhao, Xian He, Yafei Guo, Hanxiao Cheng, Shaoting Chen, Guangde Zhou, Jiabo Wang, Yawen Lu
Gynostemma pentaphyllum (Thunb.) Makino, commonly known as “southern ginseng”, contains high amounts of ginsenoside derivatives and exhibits similar biological activities with Panax ginseng (C. A. MEY) (ginseng), which is usually used as a low-cost alternative to ginseng. G. pentaphyllum has therapeutic effects on liver diseases. However, the mechanisms underlying its hepatoprotective action have not