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The Association Between Pulmonary Vascular Resistance and Posttransplant Outcomes Differs by Left Ventricular Assist Device Status. ASAIO J. (IF 3.1) Pub Date : 2024-09-25 Gaurav Gulati,Melissa R Tsoi,Jenica N Upshaw,Amanda R Vest,David DeNofrio,Michael S Kiernan
Elevated pulmonary vascular resistance (PVR) is a risk factor for mortality after heart transplantation (HT), but whether this association differs for patients with and without left ventricular assist device (LVAD) support before HT is unknown. We analyzed adult first-time HT recipients from the United Network for Organ Sharing (UNOS) registry transplanted between 2010 and 2021. We quantified the association
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Effect of Mechanical Circulatory Support on Mortality After Transcatheter Aortic Valve Replacement: A Landmark Analysis. ASAIO J. (IF 3.1) Pub Date : 2024-09-24 Chen Yang,Yang Liu,Yu Mao,Xiaoke Shang,Fan Qiao,Jian Liu,Yenong Zhou,Mengen Zhai,Shiqiang Yu,Tao Chen,Jian Yang,Zhenxiao Jin
A proportion of patients still need mechanical circulatory support (MCS) during the transcatheter aortic valve replacement (TAVR) because of intraoperative hemodynamic instability. However, the outcomes of patients with different MCS type during TAVR are still controversial. A total of 538 patients who underwent TAVR procedure in four centers were included. The time-related outcomes and their predictors
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Authors' Reply to "Membrane Exchange During ECMO Is Risky Business, But Can It Be Avoided?" ASAIO J. (IF 3.1) Pub Date : 2024-09-24 Loic Gouriet,Nicolas De Prost,Paul Masi
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Membrane Exchange During ECMO Is Risky Business, But Can It Be Avoided? ASAIO J. (IF 3.1) Pub Date : 2024-09-24 Patrick M Wieruszewski,Jamel P Ortoleva
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Randomized Clinical Trials on Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Why Are They All Negative? ASAIO J. (IF 3.1) Pub Date : 2024-09-23 Maya Guglin
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Characterization of Porcine Immunoglobulin Deposition in Human Livers Recovered Using a Xenogeneic Cross-Circulation. ASAIO J. (IF 3.1) Pub Date : 2024-09-18 Yutaka Shishido,Kaitlyn M Tracy,W Kelly Wu,Michael Cortelli,Mark Petrovic,Timothy R Harris,Victoria Simon,Sean Francois,William D Tucker,Brandon S Petree,Nancy L Cardwell,Rei Ukita,Caitlin T Demarest,Sophoclis P Alexopoulos,Ciara M Shaver,Matthew Bacchetta
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A Reduced Resistance, Concentric-Gated Artificial Membrane Lung for Pediatric End-Stage Lung Failure. ASAIO J. (IF 3.1) Pub Date : 2024-09-16 Lauren A Wich,Leah M Gudex,Tyler M Dann,Hannah J Matich,Alex J Thompson,Michael Atie,Matthew D Johnson,Robert H Bartlett,Alvaro Rojas-Peña,Ronald B Hirschl,Joseph A Potkay
The goal of the low-resistance pediatric artificial lung (PAL-LR) is to serve as a pumpless bridge-to-transplant device for children with end-stage lung failure. The PAL-LR doubles the exposed fiber length of the previous PAL design. In vitro and in vivo studies tested hemocompatibility, device flow, gas exchange and pressure drop performance. For in vitro tests, average rated blood flow (outlet SO2
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Aortic Dissection in a Neonate Receiving Extracorporeal Life Support Therapy: A Case Report. ASAIO J. (IF 3.1) Pub Date : 2024-09-11 Shivanand S Medar,Arun Chopra,T K Susheel Kumar,Jaclyn McKinstry,Keith Kuenzler,Sujata B Chakravarti,Jason Fisher
Extracorporeal life support (ECLS) therapy is increasingly being used to support children with refractory cardiorespiratory failure, but its use is occasionally associated with complications.1 Neonatal aortic dissection in association with ECLS is rare and the clinical sequelae of aortic dissection in neonates are poorly understood. We report a case of extensive type B aortic dissection in a neonate
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A Case Report About Cardiac Arrest After Left Ventricular Assist Device Explantation. ASAIO J. (IF 3.1) Pub Date : 2024-09-11 Edisson Nemer,Rami Rassam,Ann Hallberg Kristensen,Tonje Thorvaldsen,Magnus Dalén,Emil Najjar
Hemodynamic unloading by left ventricular assist devices (LVADs) in patients with advanced heart failure can result in reverse remodeling and cardiac recovery allowing pump removal. Ventriculoplasty during explantation may cause fibrosis and ventricular scars which can provide a substrate for reentry, a common cause of ventricular arrythmias. In this case report, we describe the clinical course of
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Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure. ASAIO J. (IF 3.1) Pub Date : 2024-09-11 Thomas C Palazzolo,Harutyun Sarkisyan,Giselle C Matlis,Jordon McGowan,Vakhtang Tchantchaleishvili,Randy M Stevens,Amy L Throckmorton
The translational development of pediatric ventricular assist devices (VADs) lags years behind adult device options, negatively impacting pediatric patient outcomes. To address this need, we are developing a novel, series-flow, double-blood pump VAD that integrates an axial and centrifugal pump into a single device. The axial pump is used for initial circulatory assistance in younger patients; then
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Enhancing Heart Failure Care: Deep Learning-Based Activity Classification in Left Ventricular Assist Device Patients. ASAIO J. (IF 3.1) Pub Date : 2024-09-05 Laurenz Berger,Max Haberbusch,Christoph Gross,Francesco Moscato
Accurate activity classification is essential for the advancement of closed-loop control for left ventricular assist devices (LVADs), as it provides necessary feedback to adapt device operation to the patient's current state. Therefore, this study aims at using deep neural networks (DNNs) to precisely classify activity for these patients. Recordings from 13 LVAD patients were analyzed, including heart
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Enhancing Safety in Left Ventricular Assist Device Implantation: Laparoscopic Technique for Driveline Tunneling. ASAIO J. (IF 3.1) Pub Date : 2024-09-02 Douglas Tran,Hannah Frederick,Bartley Griffith,Aakash Shah
Advancements in left ventricular assist device (LVAD) technologies have significantly lowered morbidity and mortality in patients with end-stage heart disease; however, they still carry significant risks. Though infrequent, intraabdominal injury during driveline tunneling can be catastrophic. Laparoscopic visualization can reduce these risks, especially benefiting patients with lower body mass indexes
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Extracorporeal Membrane Oxygenation-Supported Patient Outcome Undergoing Transcatheter Aortic Valve Replacement. ASAIO J. (IF 3.1) Pub Date : 2024-09-02 Akshat Banga,Vikas Bansal,Harsha Pattnaik,Tanya Amal,Anjali Agarwal,Pramod K Guru
The efficacy and safety of extracorporeal membrane oxygenation (ECMO) support during transcatheter aortic valve replacement (TAVR) remains unknown. We conducted a meta-analysis to compare benefit and risk of ECMO in TAVR patients. Bibliographic databases were searched from inception to January 1, 2024. Included studies involved patients ≥18 years old undergoing TAVR and using ECMO emergently or prophylactically
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Pulse Pressure and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis. ASAIO J. (IF 3.1) Pub Date : 2024-08-26 Andrew Kalra,Jin Kook Kang,Christopher Wilcox,Benjamin L Shou,Patricia Brown,Peter Rycus,Marc M Anders,Akram M Zaaqoq,Daniel Brodie,Glenn J R Whitman,Sung-Min Cho,
Low pulse pressure (PP) in venoarterial-extracorporeal membrane oxygenation (VA-ECMO) is a marker of cardiac dysfunction and has been associated with acute brain injury (ABI) as continuous-flow centrifugal pump may lead to endothelial dysregulation. We retrospectively analyzed adults (≥18 years) receiving "peripheral" VA-ECMO for cardiogenic shock in the Extracorporeal Life Support Organization Registry
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Aortic Root Vortex Formation During Left Ventricular Assist Device Support. ASAIO J. (IF 3.1) Pub Date : 2024-08-22 Chaztyn Pangelina,Vi Vu,Karen May-Newman
The vortex that forms in the aortic sinus plays a vital role in optimizing blood flow. Disruption of the vortex can result in flow stagnation and activate thrombus formation in the aortic root, especially when aortic valve flow is reduced as during left ventricular assist device (LVAD) support. Our goal in this study was to visualize vortex formation in an experimental model of the aortic root as flow
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Dialoxygenation: A Preclinical Trial for Transforming the Artificial Kidney Into an Oxygenator. ASAIO J. (IF 3.1) Pub Date : 2024-08-22 Dilek Karacanoğlu,Esra Bedir,Özlem Saritaş Nakip,Selman Kesici,Hatice Duran,Benan Bayrakci
Critically ill patients sometimes require tandem application of extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) which is easier and cheaper. We aimed to transform the kidney membrane into a lung membrane by adding hydrogen peroxide (H 2 O 2 ) to the dialysate as the oxygen source. A solution containing H 2 O 2 and a dialysate fluid mixture was used as the
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Development and Validation of a Novel Pediatric Mechanical Circulatory Support Risk Stratification Tool: The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) Ventricular Assist Device Score. ASAIO J. (IF 3.1) Pub Date : 2024-08-19 Carlos Bonilla-Ramirez,Angela Lorts,Joseph A Spinner,Lydia Wright,Robert A Niebler,David M Peng,Ryan R Davies,David N Rosenthal,Matthew J O'Connor
We sought to develop and validate a new risk stratification score for mortality for children supported with a ventricular assist device (VAD). This retrospective, multicenter study used data from patients undergoing VAD implantation between April 2018 and February 2023 at 44 participating institutions in the Advanced Cardiac Therapies Improving Outcomes (ACTION) network. Multivariable Cox proportional-hazards
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Extended Duration of Impella 5.5 Support Does Not Adversely Impact Outcomes Following Heart Transplantation: A National Registry Analysis. ASAIO J. (IF 3.1) Pub Date : 2024-08-19 Yeahwa Hong,Ander Dorken-Gallastegi,Umar Nasim,Nicholas R Hess,Luke A Ziegler,Mohamed Abdullah,Nidhi Iyanna,Raj Ramanan,Gavin W Hickey,David J Kaczorowski
Prior studies assessing the effects of Impella 5.5 support duration on posttransplant outcomes have been limited to single-center case reports and series. This study evaluates the impact of Impella 5.5 support duration on outcomes following heart transplantation using the United Network for Organ Sharing database. Adult heart transplant recipients who were directly bridged to primary isolated heart
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Thoracoabdominal Normothermic Regional Perfusion Using Mobile Closed Extracorporeal Circuit in Circulatory Death Determination Heart Donors. ASAIO J. (IF 3.1) Pub Date : 2024-08-14 Marta Velia Antonini,Sofia Martin-Suàrez,Luca Botta,Alessandro Circelli,Erika Cordella,Gianluca Zani,Marina Terzitta,Vanni Agnoletti,Davide Pacini
Thoracoabdominal normothermic regional perfusion (TA-NRP) is increasingly implemented in donation after circulatory determination of death (DCD). Thoracoabdominal normothermic regional perfusion allows thoracic and abdominal organs to be perfused with warm, oxygenated blood after declaration of death, interrupting ischemia. Evidence is accumulating supporting the use of TA-NRP to improve the outcome
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Successful Extracorporeal Cardiopulmonary Resuscitation Despite Aortic Occlusion. ASAIO J. (IF 3.1) Pub Date : 2024-08-09 Torben K Becker,John Bruno,Eric I Jeng,Jordan Phillips,Taylor N Smith,David L Roberts,Casey T Carr,Michol A Cooper,Martin R Back,R David Anderson,Marc O Maybauer
We present the case of a 62-year-old man with severe coronary artery disease who presented to the hospital in refractory ventricular fibrillation cardiac arrest. He showed signs of life despite prolonged resuscitation. We thus decided to initiate extracorporeal cardiopulmonary resuscitation (ECPR). The patient had a known total occlusion of his infrarenal aorta that had been surgically bypassed with
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Pressure Support Ventilation During Extracorporeal Membrane Oxygenation Support in Patients With Acute Respiratory Distress Syndrome. ASAIO J. (IF 3.1) Pub Date : 2024-08-09 Benedetta Fumagalli,Marco Giani,Michela Bombino,Denise Fumagalli,Milena Merelli,Gaia Chiesa,Roberto Rona,Giacomo Bellani,Emanuele Rezoagli,Giuseppe Foti
In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed to limit the progression of lung injury. As patients recover, transitioning to assisted mechanical ventilation can be considered to reduce the need for prolonged sedation and paralysis
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Axial Rotor Displacement Impacts Blood Pump Flow Field, Hydraulic Performance, and Hemocompatibility in MagLev Centrifugal Pump Development. ASAIO J. (IF 3.1) Pub Date : 2024-08-09 Kurt A Dasse
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In Response to Broman et al.: Time to Throw Out the Elephant in the Room: Proper Use of SvO2 in Extracorporeal Life Support. ASAIO J. (IF 3.1) Pub Date : 2024-08-09 Kevin J John,Haval Chweich
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Galectin-3 as a Prognostic Biomarker of Left Ventricular Assist Device Implantation Outcomes. ASAIO J. (IF 3.1) Pub Date : 2024-08-02 Ryan Hoang,Mary E Acosta,Mark N Belkin,Nabeel F Rasheed,Umar Siddiqi,Jennifer M Cruz,Sydney E Lupo,Corinne R Stonebraker,Sara Kalantari,Jonathan Grinstein
We assessed the prognostic potential of Galectin-3 in a sample of 159 heart failure patients who received a left ventricular assist device (LVAD) implant from 2012 to 2020. Clinical outcomes included hemodynamic data, right heart failure (RHF), hemocompatibility-related adverse events (HRAEs), and mortality. Galectin-3 was compounded into Michigan-RVF and EUROMACS-RHF risk scores and compared to the
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Estimation of Absolute Blood Volume Using Online Dialysate Dilution: When and How to Measure? ASAIO J. (IF 3.1) Pub Date : 2024-08-02 Joachim Kron,Susanne Kron
Absolute blood volume can be calculated from the increase in relative blood volume after an infusion of a well-defined volume bolus of ultrapure dialysate into the extracorporeal circulation. Several working groups have applied this method in research and clinical practice. A critical analysis of differing blood volume data between working groups revealed methodologic problems of the measurement procedure
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Cannula-Associated Deep Vein Thrombosis Following Extracorporeal Membrane Oxygenation Decannulation: Incidence and Risk Factors. ASAIO J. (IF 3.1) Pub Date : 2024-08-02 Ngan Hoang Kim Trieu,Huy Minh Pham,Tuan Anh Mai,Dai Quang Huynh,Linh Thanh Tran,Xuan Thi Phan,Thao Thi Ngoc Pham
Thrombotic complications during and after extracorporeal membrane oxygenation (ECMO) are commonly observed clinically. The incidences of cannula-associated deep vein thrombosis (CaDVT) post-ECMO support have predominantly focused on Caucasian demographics. This study aims to determine the incidence and risk factors for CaDVT in Vietnamese patients following ECMO decannulation. The retrospective study
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Heartmate 3 Left Ventricular Assist Device Bend Relief Disconnection Causing Laceration of the Outflow Graft. ASAIO J. (IF 3.1) Pub Date : 2024-07-31 Britton B Donato,Benjamin D Seadler,Buruj W Mohammed,Amber Zdanovec,H Adam Ubert,Lucian A Durham
As technology in mechanical circulatory support continues to advance, so does the utilization of durable left ventricular assist devices (LVADs). We present the first reported case of HeartMate 3 (HM3) LVAD bend relief disconnection causing laceration of the outflow graft. Our patient is a 34 year old male with end-stage heart failure status post-HM3 implantation with recent debridement of a driveline
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Time to Throw Out the Elephant in the Room: Proper Use of SvO2 in Extracorporeal Life Support. ASAIO J. (IF 3.1) Pub Date : 2024-07-31 Lars Mikael Broman,J Michael Brewer,Roberto Lorusso,Mirko Belliato,Marc O Maybauer,Michael Broomé
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Estimation of Cardiac Output Under Veno-Venous Extracorporeal Membrane Oxygenation: Comparing Thermodilution Methods to 3D Echocardiography. ASAIO J. (IF 3.1) Pub Date : 2024-07-29 Katharina Linden,Mathias Schmandt,Thomas Muders,Nils Theuerkauf,Jens-Christian Schewe,Ulrike Herberg,Christian Putensen,Stefan Felix Ehrentraut,Stefan Kreyer
Thermodilution methods to determine cardiac output (CO) may be affected by veno-venous extracorporeal membrane oxygenation (ECMO). We compared CO estimations by pulmonary arterial thermodilution using a pulmonary arterial catheter (COPAC), transpulmonary thermodilution (COTPTD), and three-dimensional echocardiography (3DEcho) (CO3DEcho) in 18 patients under veno-venous ECMO. Comparisons between CO3DEcho
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Impact of Cardiac Resynchronization Therapy on Ventricular Arrhythmias and Survival After Durable Left Ventricular Assist Device Implantation. ASAIO J. (IF 3.1) Pub Date : 2024-07-29 Connor P Oates,Luke L Lawrence,Grace E Bigham,Namratha S Meda,Binaya Basyal,Sriram D Rao,Cyrus A Hadadi,Samer S Najjar,Manish H Shah,Farooq H Sheikh,Phillip H Lam
The impact of cardiac resynchronization therapy (CRT) in patients receiving durable left ventricular assist device (LVAD) implantation remains unclear and there is no consensus regarding postoperative management. We sought to determine the impact of postoperative management of CRT on clinical outcomes following LVAD implantation. A total of 789 patients underwent LVAD implantation at our institution
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Hemodynamic Ramp Testing for Left Ventricular Assist Devices: Overcoming Biology. ASAIO J. (IF 3.1) Pub Date : 2024-07-26 Sheng Fu,Rohan Samson
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Signs of Hemolysis Predict Mortality and Ventilator Associated Pneumonia in Severe Acute Respiratory Distress Syndrome Patients Undergoing Veno-Venous Extracorporeal Membrane Oxygenation. ASAIO J. (IF 3.1) Pub Date : 2024-07-26 Emanuele Rezoagli,Michela Bombino,Lorraine B Ware,Eleonora Carlesso,Roberto Rona,Giacomo Grasselli,Antonio Pesenti,Giacomo Bellani,Giuseppe Foti
Cell-free hemoglobin (CFH) is used to detect hemolysis and was recently suggested to trigger acute lung injury. However, its role has not been elucidated in severe acute respiratory distress syndrome (ARDS) patients undergoing extracorporeal membrane oxygenation (ECMO). We investigated the association of carboxyhemoglobin (COHb) and haptoglobin-two indirect markers of hemolysis-with mortality in critically
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Immediate Clinical Complications Occurring During Membrane Change in Patients on Veno-Venous Extracorporeal Membrane Oxygenation. ASAIO J. (IF 3.1) Pub Date : 2024-07-25 Paul Masi,Loic Gouriet,Costin Radu,Thierry Folliguet,Antonio Fiore,Romain Gallet,François Bagate,Armand Mekontso Dessap,Nicolas De Prost
The clinical tolerance of extracorporeal membrane oxygenation (ECMO) membrane changes in acute respiratory distress syndrome (ARDS) patients under veno-venous ECMO (VV-ECMO) has not been reported. The aim of this study was to describe the tolerance of membrane change. Patients requiring VV-ECMO were retrospectively included between March 2020 and May 2022. In case of membrane dysfunction or an increase
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A Mock Circulatory Loop Analysis of Cardiorenal Hemodynamics With Intra-Aortic Mechanical Circulatory Support. ASAIO J. (IF 3.1) Pub Date : 2024-07-25 Sumita Barua,Michael Stevens,Pankaj Jain,Gabriel Matus Vazquez,Laurence Boss,Kavitha Muthiah,Christopher Hayward
Type 1 cardiorenal syndrome is associated with significant excess morbidity and mortality in patients with severe acute decompensated heart failure. Previous trials of vasoactive drugs and ultrafiltration have not shown superiority over placebo or intravenous diuretics. Pilot data suggest short-term mechanical support devices may support diuresis in the cardiorenal syndrome. We evaluated the intra-aortic
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Extubated, Rehabilitation-Focused Extracorporeal Membrane Oxygenation for Pediatric Coronavirus Disease 2019: A Case Series. ASAIO J. (IF 3.1) Pub Date : 2024-07-25 Kevin B Kilgallon,Matthew Leroue,Sara Shankman,Taryn Shea,Shannon Buckvold,Max Mitchell,Gareth Morgan,Jenny Zablah,Aline B Maddux
During the coronavirus 2019 (COVID-19) pandemic, children suffered severe lung injury resulting in acute respiratory distress syndrome requiring support with extracorporeal membrane oxygenation (ECMO). In this case series, we described our center's experience employing a rehabilitation-focused ECMO strategy including extubation during ECMO support in four pediatric patients with acute COVID-19 pneumonia
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Impact of Extracellular Matrix Injury on the Calcification of Artificial Bovine Pericardial Leaflets: An Experimental Study. ASAIO J. (IF 3.1) Pub Date : 2024-07-24 Honghuan Yu,Xinfeng Yang,Long Wang,Kai Xing,Tao Zhang,Xiaochun Ma,Xiaolin Liu,Zhengjun Wang
To investigate the role of extracellular matrix (ECM) injury in bioprosthetic valve calcification, we constructed an ECM damage model by applying a 15 N stress to the bovine pericardium sample in both transverse and longitudinal directions after tissue cross-linking, whereas no stress was applied in the control group. Then we implanted two pieces of bovine pericardium on both sides of the dorsal midline
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Antithrombotic and Antimicrobial Potential of S-Nitroso-1-Adamantanethiol-Impregnated Extracorporeal Circuit. ASAIO J. (IF 3.1) Pub Date : 2024-07-22 Orsolya Lautner-Csorba,Roopa Gorur,Terry Major,Jianfeng Wu,Partha Sheet,Joseph Hill,Minzhi Yu,Chuanwu Xi,Robert H Bartlett,Steven P Schwendeman,Gergely Lautner,Mark E Meyerhoff
This study presents the utilization of a novel, highly lipophilic nitric oxide (NO) donor molecule, S-nitroso-1-adamantanethiol (SNAT), for developing an NO-emitting polymer surface aimed at preventing thrombus formation and bacterial infection in extracorporeal circuits (ECCs). S-nitroso-1-adamantanethiol, a tertiary nitrosothiol-bearing adamantane species, was synthesized, characterized, and used
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Blood Transfusion During Extracorporeal Membrane Oxygenation: An ELSO Position Statement. ASAIO J. (IF 3.1) Pub Date : 2024-07-18 Kollengode Ramanathan,Giles Peek,Gennaro Martucci,Huda Al Foudri,Priya Nair,Javier Kattan,Ravi Thiagarajan,Bingwen Eugene Fan,Cara Agerstand,Graeme MacLaren,Robert Bartlett
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Pulsatility of Pulmonary Artery Waveforms Before and After Left Ventricular Assist Device Is Associated With Right Ventricular Failure. ASAIO J. (IF 3.1) Pub Date : 2024-07-17 Andrew N Rosenbaum,Atta Behfar,Timothy L Rossman,Scott W Lundgren
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Characterization of Protein Binding on an Extracorporeal Membrane Oxygenation (ECMO) Circuit Following the Priming Procedure. ASAIO J. (IF 3.1) Pub Date : 2024-07-12 Tengyi Cai,Samantha J Emery-Corbin,Conor McCafferty,Suelyn Van Den Helm,Natasha Letunica,Rebecca Barton,Chantal Attard,Stephen Horton,Steve Bottrell,Bradley Schultz,Graeme MacLaren,Roberto Chiletti,Derek Best,Amy Johansen,Fiona Newall,Warwick Butt,Yves d'Udekem,Laura F Dagley,Jumana M Yousef,Paul Monagle,Vera Ignjatovic
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Extracorporeal Membrane Oxygenation in Amniotic Fluid Embolism: A Systematic Review of Case Reports. ASAIO J. (IF 3.1) Pub Date : 2024-07-09 Ngan Hoang Kim Trieu,Nam Nhat Nguyen,Huy Minh Pham,Dai Quang Huynh,Anh Tuan Mai
Amniotic fluid embolism (AFE) is an obstetric complication that can result in acute circulatory failure during and after labor. The effectiveness of extracorporeal membrane oxygenation (ECMO) in AFE patients has not been established, especially in the context of coagulopathy. This review aims to evaluate the efficacy of ECMO support in AFE patients. We conducted a systematic review of case reports
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Reduction in Balloon Pump Size Reduces Axillary Intraaortic Balloon Pump Failure Risk. ASAIO J. (IF 3.1) Pub Date : 2024-07-09 Sara S Inglis,Ardaas Kanwar,Hilda Gonzalez Bonilla,Swaiman Singh,Jennifer Y Pearson,Mohsin Abbas,Lori A Folkens,Narith N Ou,Philip J Spencer,Mauricio A Villavicencio,Alfredo L Clavell,Robert P Frantz,Andrew N Rosenbaum,Atta Behfar
Axillary artery intra-aortic balloon pump (axIABP) placement has been implemented as a bridging solution before heart transplantation. This study evaluates complications associated with axIABP support and describes an approach to minimize adverse events. We previously described a percutaneous approach for axIABP placement. However, patients receiving axIABP between September 1, 2017, and September
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Anticoagulation Can Be Held in Traumatically Injured Patients on Veno-Venous Extracorporeal Membrane Oxygenation Support. ASAIO J. (IF 3.1) Pub Date : 2024-07-08 Erin Niles,Rishi Kundi,Thomas Scalea,Meaghan Keville,Samuel M Galvagno,Douglas Anderson,Appajosula Rao,James Webb,Meredith Peiffer,Tyler Reynolds,Jody Cantu,Elizabeth K Powell
Traumatic injury is associated with several pulmonary complications, including pulmonary contusion, transfusion-related acute lung injury (TRALI), and the development of acute respiratory distress syndrome (ARDS). There is a lack of literature on these patients supported with veno-venous extracorporeal oxygenation (VV ECMO). Understanding the safety of using VV ECMO to support trauma patients and the
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A Clinicopathological Case of Left Ventricular Assist Device Outflow Graft Stenosis. ASAIO J. (IF 3.1) Pub Date : 2024-07-08 Yusuf Ziya Sener,Cornelis W van der Heiden,Jelena Sjatskig,Jan von der Thüsen,Kadir Caliskan
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Routine Versus Selective Distal Perfusion Catheter Use in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO J. (IF 3.1) Pub Date : 2024-07-01 Kevin G Buda,Emilie C Robinson,Jessica Titus,Peter M Eckman,Ivan Chavez,Ellen Cravero,Larissa Stanberry,Katarzyna Hryniewicz
Although current studies support the use of prophylactic distal perfusion catheters (DPCs) to decrease limb ischemia in patients on venoarterial extracorporeal membrane oxygenation (VA ECMO), methods for monitoring limb ischemia differ between studies. We evaluated the safety of a selective rather than prophylactic DPC strategy at a single center with a well-established protocol for limb ischemia monitoring
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Prone Positioning and Right Ventricular Protection During Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. ASAIO J. (IF 3.1) Pub Date : 2024-06-28 Vasileios Zochios,Hakeem Yusuff,Marta Velia Antonini,
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Transesophageal Echocardiography Guided Veno-Pulmonary Extracorporeal Membrane Oxygenation Cannula Insertion Technique. ASAIO J. (IF 3.1) Pub Date : 2024-06-27 Luke Landolt,Gregory M Janelle,William Ricks,Mindaugas Rackauskas,Marc O Maybauer
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ECPELLA: Beyond a Left Ventricular Venting Strategy When to Unload the Left Ventricle and How to Decide. ASAIO J. (IF 3.1) Pub Date : 2024-06-27 John Kuckelman,Phil Coffey,Musa Sharkawi,Caryl Bailey,Evan Hiner,Vijay Patel
Left ventricular (LV) unloading has been shown to improve survival for patients requiring veno-arterial extracorporeal membrane oxygenation (VA ECMO) support for cardiogenic shock. A mortality benefit has been shown for ECMO and concomitant placement of a transcatheter unloading LV pump such as an Impella device (colloquially referred to as ECPELLA or ECMELLA) for patients resuscitated with VA ECMO
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Noninvasive Ventilation Before Intubation and Mortality in Patients Receiving Extracorporeal Membrane Oxygenation for COVID-19: An Analysis of the Extracorporeal Life Support Organization Registry. ASAIO J. (IF 3.1) Pub Date : 2024-06-27 Marco Giani,Emanuele Rezoagli,Ryan P Barbaro,Jordi Riera,Giacomo Bellani,Laurent Brochard,Alain Combes,Giuseppe Foti,Daniel Brodie
Bilevel-positive airway pressure (BiPAP) is a noninvasive respiratory support modality which reduces effort in patients with respiratory failure. However, it may increase tidal ventilation and transpulmonary pressure, potentially aggravating lung injury. We aimed to assess if the use of BiPAP before intubation was associated with increased mortality in adult patients with coronavirus disease 2019 (COVID-19)
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Impella RP Flex: Rescue for the Failing Right Ventricle After Heart Transplantation-Case Report. ASAIO J. (IF 3.1) Pub Date : 2024-06-24 Akanksha Agrawal,Joel Shoemaker,Swaroop Bommareddi,Ioana Dumitru
Right ventricular (RV) dysfunction (RVD) after orthotopic heart transplantation (OHT) is a common cause of morbidity and mortality. Impella RP Flex was recently approved for RV support as a temporary mechanical circulatory device. We present the first case of its use in managing RVD in a patient after OHT. Here, a 40 year old male patient with familial dilated cardiomyopathy and factor V Leiden mutation
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Mechanical Ventilation During Extracorporeal Membrane Oxygenation: Getting the Oxygenation Right. ASAIO J. (IF 3.1) Pub Date : 2024-06-24 Olivier van Minnen,Floris E J Jolink,Walter M van den Bergh,Joep M Droogh,Annemieke Oude Lansink-Hartgring
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Immunofluorescence Protocol for Characterization of Platelet and Leukocyte Binding in Extracorporeal Membrane Oxygenation (ECMO) Circuits. ASAIO J. (IF 3.1) Pub Date : 2024-06-21 Tengyi Cai,Matthew Burton,Conor McCafferty,Suelyn Van Den Helm,Natasha Letunica,Chantal Attard,Stephen Horton,Steve Bottrell,Bradley Schultz,Graeme MacLaren,Roberto Chiletti,Derek Best,Amy Johansen,Fiona Newall,Warwick Butt,Yves d'Udekem,Paul Monagle,Vera Ignjatovic
The continuous contact between blood and the foreign surface of the extracorporeal membrane oxygenation (ECMO) circuit contributes to hemostatic, inflammatory, and other physiological disturbances observed during ECMO. Although previous studies have extensively investigated blood samples from patients on ECMO, cell adsorption to the ECMO circuit as an additional factor that could potentially influence
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Carbon Dioxide Targets in Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. ASAIO J. (IF 3.1) Pub Date : 2024-06-21 Torben M Rixecker,Vanessa Ast,Elianna Rodriguez,Vitalie Mazuru,Gudrun Wagenpfeil,Sebastian Mang,Ralf M Muellenbach,Leda Nobile,Jonas Ajouri,Robert Bals,Frederik Seiler,Fabio Silvio Taccone,Philipp M Lepper
Target values for arterial carbon dioxide tension (PaCO2) in extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) are unknown. We hypothesized that lower PaCO2 values on ECMO would be associated with lighter sedation. We used data from two independent patient cohorts with ARDS spending 1,177 days (discovery cohort, 69 patients) and 516 days (validation cohort, 70
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Backwash Maneuver for HeartMate3 Inflow Thrombosis: Experience From Two Cases. ASAIO J. (IF 3.1) Pub Date : 2024-06-20 Nikolaos Cholevas,Christoph Hoermandinger,Isabell Anna Just,Nikolaos Politis,Volkmar Falk,Evgenij Potapov,Felix Schoenrath
The ingested pump inflow thrombus, although rare, is a potentially life-threatening complication of left ventricular assist devices. During the last years, the backwash maneuver is considered an alternative method to pump replacement for the treatment of inflow thrombosis, showing high success rate in selected patients with HeartWare HVAD devices. However, that was not the case in our present report
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New Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress Syndrome on Venovenous Extracorporeal Membrane Oxygenation. ASAIO J. (IF 3.1) Pub Date : 2024-06-20 Caroline Holton,Sanket Shah,Jenna O Miller
The development of new right ventricular (RV) dysfunction after cannulation to venovenous (VV) extracorporeal membrane oxygenation (ECMO) and its association with worse outcomes is increasingly recognized in adult patients, however, no studies have evaluated this phenomenon in pediatric patients. We report results of a single-center retrospective cohort study at a large academic children's hospital
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The Use of Impella 5.5 Reduces Pulmonary Vascular Resistance as Bridge to Heart Transplant in a Pediatric Patient. ASAIO J. (IF 3.1) Pub Date : 2024-06-18 Bradley Oelkers,Erin Schumer,Andrea N Lambert,Bahaaldin Alsoufi,Deborah Kozik,Sarah J Wilkens
This case report explores the successful use of the Impella 5.5 (Abiomed Inc., Danvers, MA) device in a 22 kg, 0.89 body surface area (BSA) pediatric patient with longstanding dilated cardiomyopathy and elevated pulmonary vascular resistance. The article details the device selection, management, and outcome demonstrating the feasibility and potential benefits of the Impella 5.5 as a device within the
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Early Postoperative Changes in Von Willebrand Factor Activity Are Associated With Future Bleeding and Stroke in HeartMate 3 Patients. ASAIO J. (IF 3.1) Pub Date : 2024-06-18 Parsa Jahangiri,Kevin M Veen,Iris van Moort,Jeroen H Bunge,Alina Constantinescu,Jelena Sjatskig,Moniek de Maat,Jolanda Kluin,Frank Leebeek,Kadir Caliskan
Hemocompatibility-related adverse events (HRAEs), particularly gastrointestinal bleeding, remain a frequent complication after left ventricular assist device (LVAD) implantation. The current study sought to describe and analyze whether early (<60 days) postoperative von Willebrand factor (VWF) activity assays predict the risk of gastrointestinal bleeding and stroke. A prospective single-center study
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Evaluation of the Nautilus Smart Extracorporeal Membrane Oxygenation in Patients With Hemostatic Alteration: A Case Series. ASAIO J. (IF 3.1) Pub Date : 2024-06-17 Mauro Renghini,Debora Maddinelli,Anna Papeo,Carmine Puglia,Andrea Montisci,Sergio Cattaneo,Stefano Benussi
The intricate management of hemostatic disorders in extracorporeal membrane oxygenation (ECMO) assisted patients poses challenges, particularly when procoagulant administration is necessary. We hereby report the performance of the Nautilus* Smart ECMO Module in three patients with hemostatic disorders. We collected data from ECMO procedures with Nautilus* Smart ECMO Module and analyzed the performance:
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Outcomes After Heartmate 3 Left Ventricular Assist Device Implantation Using a 10 mm Outflow Graft. ASAIO J. (IF 3.1) Pub Date : 2024-06-17 Berhane Worku,Alice Vinogradsky,Aminat Ibrahim,Camilla Sofia Rossi,Charles Mack,Ivancarmine Gambardella,Ankur Srivastava,Koji Takeda,Yoshifumi Naka
The presence of adhesions and patent bypass grafts may create challenges for standard 14 mm outflow graft placement during left ventricular assist device implantation. We retrospectively describe our experience using a 10 mm Bioline Fusion graft (Getinge, Goteborg, Sweden) as the outflow graft in patients undergoing primary Heartmate 3 (Abbott, Abbott Park, IL) implantation. One hundred one patients
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The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study. ASAIO J. (IF 3.1) Pub Date : 2024-06-05 Chris H H Chan,Margaret R Passmore,Oystein Tronstad,Helen Seale,Mahe Bouquet,Nicole White,Jun Teruya,Airlie Hogan,David Platts,Wandy Chan,Alexander M Dashwood,David C McGiffin,Andrew J Maiorana,Christopher S Hayward,Michael J Simmonds,Geoff D Tansley,Jacky Y Suen,John F Fraser,Bart Meyns,Libera Fresiello,Steven Jacobs
Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective