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Prominent tissue hemophagocytic lymphohistiocytosis obscuring primary cutaneous gamma/delta (γδ) T-cell lymphoma. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-18 Craig M Fisher,Steven F Capen,Justin P Bandino,Allen R Holmes,Christine M Lee
Primary cutaneous gamma/delta (γδ) T-cell lymphoma (PCGDTCL) is a rare, aggressive malignant neoplasm of γδ T lymphocytes arising within the skin and subcutis. We present a challenging case of PCGDTCL diagnosed in a 35-year-old male soldier who presented with constitutional symptoms, pancytopenia, hemophagocytic lymphohistiocytosis (HLH), disseminated lymphadenopathy, and cutaneous lesions on his extremities
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Clinicopathological and molecular spectrum of patients with germline SUFU mutations: A case series J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-14 Mashiro van Dal, Sanne R. Martens‐de Kemp, Antien L. Mooyaart, Walter Voogt, Marlies Wakkee, Jeffrey Damman
BackgroundOne of the hereditary syndromes associated with multiple early‐onset basal cell carcinomas (BCCs) is basal cell nevus syndrome (BCNS), of which a minority is caused by germline SUFU mutations. Germline SUFU mutations show a spectrum of phenotypes, of which multiple hereditary infundibulocystic basal cell carcinoma syndrome (MHIBCC) is one. Patients with MHIBCC develop multiple basaloid skin
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Gram stain of skin tissue sections: The difficulty in establishing diagnostic standards for skin and soft tissue infections J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-13 Hiroshi Ito
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Human cutaneous pythiosis: A case report J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-13 Nutpeera Nutthapan, Wuttinee Sutichaiworapong, Yu‐Hung Wu
Human pythiosis is a rarely encountered yet potentially harmful infectious disease. It is mostly caused by Pythium insidiosum, an aquatic fungal‐like organism, and primarily manifests in tropical locales such as India and Thailand. Cutaneous/subcutaneous pythiosis accounts for a small proportion of all clinical forms. The relationship between cutaneous pythiosis and hemoglobinopathy remains uncertain
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Histopathologic features in drug‐induced, malignancy‐associated, or idiopathic linear IgA bullous dermatosis: A retrospective comparative cohort study of 65 patients J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-13 Katherine L. Wang, Austin Todd, Dawn M. R. Davis, Julia S. Lehman
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Martin C. Mihm Jr: Remembrances of a great physician, charismatic person, and good friend J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-11 Robert H. Young
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Ancillary immunohistochemistry testing for loss of p16 in melanoma: A systematic review and meta‐analysis of diagnostic accuracy studies J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-11 Shruti S. Chinchanikar, Garth R. Fraga
BackgroundAncillary immunohistochemistry testing for p16 loss has been proposed as a diagnostic tool for melanoma, but its accuracy remains uncertain.MethodsA systematic review and meta‐analysis were conducted on 26 studies involving 979 melanomas and 974 nevi.ResultsThrough bivariate analysis of data across all cut‐off values, the sensitivity and specificity were calculated to be 0.55 (95% confidence
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Mutational profile of the KIT gene and its heterogeneity in primary and metastatic melanomas J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-09-04 Jesús José André Quintana Castillo, Gilles Landman, Mariana Fernandes, Denise Barcelos
BackgroundThis study investigates the mutational profile of the KIT gene in primary and metastatic melanomas, highlighting the significance of genetic heterogeneity.MethodsThis research is a retrospective cohort that includes formalin‐fixed and paraffin‐embedded melanoma samples obtained from Hospital São Paulo, Brazil, between the years of 1996 and 2010. The research encompasses primary melanomas
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The association of interleukin‐36 staining intensity with histopathologic findings of eosinophil count and spongiosis in patients with psoriasis: A secondary analysis of a retrospective immunohistochemical and chart review pilot study J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-31 William R. Zhang, Tina Bhutani, Joshua M. Schulman, Jeffrey P. North
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A case of NONO::TFE3 cutaneous epithelioid and spindle cell tumor with local recurrence after complete excision J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-29 Joseph S. Durgin, Emily H. Smith, Paul W. Harms, Noah A. Brown, May P. Chan
Mesenchymal tumors may display morphologic and immunohistochemical overlap with melanocytic tumors, presenting a pitfall for misdiagnosis. We report a 62‐year‐old woman who presented with a recurrent dermal and subcutaneous tumor over the Achilles tendon 15 years following complete excision. Both the primary and the recurrent tumors were characterized by nests and sheets of epithelioid and spindle
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NRASQ61R‐driven atypical melanocytic tumor with blue nevus‐like morphology: A case report J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-23 Tsubasa Hiraki, Hiroki Mori, Junko Misawa, Marina Yunoki, Keisuke Goto
NRAS Q61 mutations are driver genetic alterations associated with common melanocytic nevi. Herein, we describe a case of NRAS‐mutant melanocytic tumor with a blue nevus‐like morphology. A 71‐year‐old Japanese man presented with a 4.6‐mm nodule on his back. Histopathological examination revealed a dense distribution of spindle‐shaped melanocytes in the upper dermis and a sparse distribution of dendritic
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Recurrence of an erythrodermic mycosis fungoides as a biologically indolent anaplastic large T‐cell lymphoma initially misdiagnosed as being of donor origin J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-23 Francisco Javier Díaz de la Pinta, Rebeca Manso, Juan Torre, Luis Requena, Socorro Maria Rodriguez‐Pinilla
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A rare case of metastatic osteoblastic osteosarcoma to the scalp J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-23 Efrain Lee‐Diaz, Brittany L. Dulmage, Swati Satturwar, Jose A. Plaza
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Histopathologic, genomic, transcriptomic, and functional characteristics of eight melanocytic tumors with BRAF fusions showing stronger MAPK pathway activation compared to BRAF V600E tumors J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-22 Aofei Li, Simon J. Warren, Brandon A. Umphress, Ahmed K. Alomari
BackgroundActivating BRAF gene alterations are central to melanocytic tumor pathogenesis. A small, emerging subset of melanocytic tumors driven by BRAF fusions has distinct therapeutic implications and has been described to have Spitzoid morphology patterns. However, such morphological patterns do not encompass all cases, and little is known about the functional molecular events.Materials and MethodsWe
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Angioplasmacellular hyperplasia: Livid exophytic nodule on the anterior hairline J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-21 Tey Hwee Ting Vanessa, Koh Hong Yi, Joel Lim Hua‐Liang
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An exceptional case of imatinib mesylate inducing both psoriasis and lichenoid reaction: A case report. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-20 Kaoutar Belharti,Hasnae Saddouk,Nassiba Zerrouki,Siham Dikhaye,Nada Zizi
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Evaluation of PRAME immunohistochemistry in cutaneous vascular neoplasms reveals frequent expression in primary and post‐irradiation cutaneous angiosarcomas J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-17 Andrea Krajisnik, Neda Rezaee, Eleanor R. Duncan, Bonnie L. Balzer, Wonwoo Shon
BackgroundPreferentially expressed antigen in melanoma (PRAME) has been extensively studied in cutaneous melanocytic tumors and has proven valuable as a diagnostic adjunct in routine dermatopathology practice. However, its expression in cutaneous vascular neoplasms, particularly angiosarcomas (AS), remains largely unexplored.MethodsTo further explore PRAME expression in cutaneous AS, 18 cases of post‐irradiation
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Atypical clinical presentation of eosinophilic angiocentric fibrosis with cutaneous and upper respiratory tract involvement J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-15 Juan Manuel Liñán‐Barroso, Nicolás Valérdiz‐Menéndez, José Salvador García‐Morillo, José Bernabeu‐Wittel
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Granulomatous secondary syphilis: When to maintain a high index of suspicion? J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-14 Monia Di Prete, Alessandra Latini, Viviana Lora, Fulvia Pimpinelli, Carlo Cota
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Widespread purplish‐red plaques with plasma cell infiltrate: A rare type of lichen planus J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-10 Szeman Cheung, Jie Zheng, Xiaoqing Zhao
Diseases in which cutaneous plasma cell infiltrates predominate are rare and usually of unknown etiology, including those that transition from benign to malignant, such as cutaneous plasmacytosis, multicentric Castleman disease, and extramedullary plasmacytoma. These diseases may present as purplish, reddish‐brown cutaneous plaques or nodules. Here, we report an exceptional case of lichen planus (LP)
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Cutaneous Rosai–Dorfman disease with MAP2K1 mutation, initially mimicking an infection with parasitized histiocytes J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-10 Joseph Gillam, Ruchi Desai, Raphael J. Louie, Scott A. Turner, Grace Y. Wang, Julio A. Diaz‐Perez, Mark C. Mochel
Rarely, Rosai–Dorfman disease (RDD) manifests exclusively in the skin, typically as nodules on the trunk and extremities. Recognition of characteristic histopathologic features enables diagnosis of RDD. A 55‐year‐old female presented with a 7‐year history of cutaneous nodules involving the trunk and extremities. A prior skin biopsy specimen at a different institution had demonstrated a dense dermal
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Subcellular expression of CD30 in cutaneous mastocytosis—An important factor for targeted treatment J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-08-02 Christina Mitteldorf, Aleksandra Kulberg, Michael Tronnier, Michael P. Schön, Werner Kempf
BackgroundThe subcellular distribution of CD30 on mast cells and the presence of eosinophils in cutaneous mastocytosis require further investigation, especially as the cell surface expression of CD30 is critical for the therapeutic response of systemic mastocytosis to brentuximab vedotin.ObjectiveInvestigation of 147 biopsy specimens from 143 patients with cutaneous mastocytosis for mast cell density
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A comparison of mast cells in skin biopsies of cutaneous mastocytosis with other inflammatory dermatoses: A study of 33 cases J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-31 Margaret M. Parham, Bhuvaneswari Krishnan, Yve T. Huttenbach
BackgroundHistopathologic criteria for diagnosis of cutaneous mastocytosis include 20 mast cells per high‐power field or clusters of 15 mast cells. We aimed to determine the specificity of these criteria for cutaneous mastocytosis in comparison with inflammatory disorders of mast cell activation.MethodsTwenty‐six cases of spongiotic dermatitis or urticaria were identified from 2021 to 2022. Recuts
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Primary cutaneous lymphoproliferations in the gray zone between marginal zone lymphoma and CD4+ small/medium T‐cell lymphoproliferative disease J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-31 Kata Pálos, József Szakonyi, Judit Csomor, Åsa Gremsperger, Erik Zajta, Márta Marschalkó, Ágota Szepesi
BackgroundPrimary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disease (CD4+ TLPD) are two distinct entities with excellent prognosis; however, they show profound clinical and histopathological similarities, leading to differential diagnostic uncertainty.AimsOur aim was to review and reanalyze cases of primary cutaneous lymphoproliferations
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The concept of onychodermis containing onychofibroblasts has histological (microanatomical), immunohistochemical as well as molecular basis J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-24 Joonho Shim, Ji‐Hye Park, Taemin Lee, Dongyoun Lee, Kee‐Taek Jang
The terms “onychofibroblast” (nail‐specific fibroblast) and onychodermis (nail‐specific dermis) were first introduced in 2006 and 2012, respectively, based on distinctive histologic and immunohistochemical features from the dermis of the surrounding skin and have been demonstrated in multiple studies. Recently, based on molecular research, the definition of onychodermis containing onychofibroblasts
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A rare case of hidradenocarcinoma with anaplastic and invasive features arising from a nodulocystic hidradenoma J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-18 Myles R. McCrary, Kate E. Beekman, Carolina Strosberg, Leslie Turner, Eugene Sanik, Thomas M. Beachkofsky
A 91‐year‐old man presented with a cutaneous left abdominal mass. The mass was longstanding (over 5 years) and slow‐growing. Examination revealed a violaceous, multinodular, and exophytic non‐tender mass surrounded by patchy erythema. Excisional biopsy was performed and revealed a nodular and cystic dermal proliferation of predominately basaloid cells with focal duct formation, surrounded by prominent
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Assessing T‐cell receptor clonality by next‐generation sequencing in atypical cutaneous lymphoid infiltrates and cutaneous T‐cell lymphoma: A scoping review J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-18 Michi M. Shinohara, Kerri E. Rieger, Uma Sundram, Maxwell A. Fung, Alexandra C. Hristov
The diagnosis of cutaneous T‐cell lymphoma (CTCL) remains challenging. Demonstration of a clonal T‐cell population using T‐cell receptor (TCR) gene rearrangement studies by next‐generation sequencing (NGS) has been explored in several studies. This review summarizes the current literature on NGS‐based sequencing methods for the assessment of TCR clonality in the evaluation of atypical cutaneous lymphoid
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Atypical cellular neurothekeoma of the oral mucosa: A rare case report and literature review J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-18 Hélen Kaline Farias Bezerra, Gabriele Prospero Nakamura, Bruno Augusto Linhares Almeida Mariz, Rodrigo Nascimento Lopes, José Divaldo Prado, Ana Luiza Oliveira Corrêa Roza, Pablo Agustin Vargas
Cellular neurothekeoma (CN) is a benign dermal neoplasm that most often affects the head and neck region and rarely occurs in the oral mucosa. We report a rare case of CN with atypical features on the floor of the mouth and summarize the reported cases of oral CN in English‐language literature. A 62‐year‐old woman presented with a 6‐month history of a painless mass on the floor of the mouth. Histopathological
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Clinicopathologic features of pityriasis rosea‐like drug eruption secondary to imatinib: A case report and review of the literature J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-18 Joseph S. Durgin, Carli P. Whittington, Jane Harrell, Julie E. Mervak, Emily H. Smith
Pityriasis rosea is an acute, self‐limited exanthem that typically occurs in adolescence and young adulthood, classically featuring ovoid erythematous and scaly lesions on the trunk and proximal extremities. While its cause is not definitively known, the classic form of pityriasis rosea may result from the reactivation of latent human herpesvirus (HHV) infections (HHV‐6 and HHV‐7). Interestingly, drug
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Impact of the adjunction of a short video to an original article for the recognition of newly described tumor entities in pathology: An interventional prospective study J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-17 Antoine Taillandier, François Avry, Elodie Miquelestorena‐Standley, Mahtab Samimi, Arnaud de la Fouchardière, Nicolas Macagno, Thibault Kervarrec
ContextMerkel cell carcinoma diagnosis is often based on microscopic examination by pathologists. While histopathologic diagnosis primarily hinges on conscious and analytical cognition, the pathologist's decision‐making process is also influenced by a rapid “gist” or “gestalt” approach. In this study, using cases of Merkel cell carcinoma as a model, we aim to assess how pathologists' viewing short
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Case of a CIC::DUX4 fusion gene in a vascular neoplasm extends the spectrum of CIC‐rearranged sarcomas J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-16 William R. Jeck, Sarah Rapisardo, Barbara A. Anderson, Peter Hendrickson, George Jour, Richard F. Riedel, Brian E. Brigman, Rami N. Al‐Rohil
CIC‐rearranged sarcomas comprise a group of exceptionally aggressive round‐cell sarcomas. These tumors most commonly demonstrate CIC::DUX4 fusion and show similar histopathology to Ewing sarcomas, though lesions mimicking vascular neoplasms have recently been described. Here, we describe a case of a patient with CIC::DUX4 fusion sarcoma identified using RNA‐based molecular testing who was initially
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Enfortumab vedotin‐induced cutaneous eruption: Ring mitotic figures as a distinctive histopathologic feature J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-16 Catherine Sport, Rebecca C. Clawson, Lauren E. Tisdale, John W. Melson, Mark C. Mochel
Enfortumab vedotin (EV), a nectin‐4‐binding agent that affects microtubules, has become standard therapy for advanced urothelial carcinoma. The agent, now given in combination with pembrolizumab, frequently induces cutaneous reactions. Here, we report a severe EV‐induced cutaneous eruption. A 58‐year‐old woman with metastatic urothelial carcinoma developed a rash after receiving simultaneous first
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Dermatomyositis‐like skin eruptions under hydroxyurea therapy conceal TP53‐mutated atypical keratinocytes: A histopathologic and molecular pathologic case series J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-15 Wiebke Pruessmann, Jutta Kirfel, Verena‐Wilbeth Sailer, Christian Rose
Hydroxyurea is an antimetabolite that inhibits DNA synthesis and is used as a treatment option in chronic myeloproliferative disorders. Rarely, “dermatomyositis (DM)‐like” skin lesions are observed after long‐term therapy. In this case series, five skin biopsies of four patients were evaluated by histology, immunohistochemistry, and next‐generation sequencing of the TP53 gene locus. All biopsies showed
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Clinically amyopathic dermatomyositis: Clinical, laboratory, and histopathological features J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-15 Xintong Wang, Ellen De Moll, Merav Koschitzky, Nahla Shihab, Saakshi Khattri, Robert Phelps
BackgroundDespite the advancements in the categorization of clinically amyopathic dermatomyositis (CADM), the classification and diagnosis of its subtypes are still challenging. The aim of our study was to describe the clinicopathological features of CADM and assess the differences between amyopathic dermatomyositis (ADM) and hypomyopathic dermatomyositis (HDM).MethodsThis retrospective study included
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Myelodysplasia cutis and VEXAS syndrome initially diagnosed as histiocytoid Sweet syndrome: A diagnostic pitfall J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-12 Serena J. Shimshak, Sion Jasmine, Mark D. P. Davis, Emma F. Johnson, Margot S. Peters, Gang Zheng, Olayemi Sokumbi, Nneka I. Comfere
Histiocytoid Sweet syndrome (H‐SS) is a histopathological variant of Sweet syndrome (SS) defined by cutaneous infiltration of immature myeloid cells morphologically resembling histiocytes. The association of H‐SS with underlying malignancy, particularly myelodysplastic syndromes, is well‐established. Myelodysplasia cutis (MDS‐cutis) has been proposed to describe cases historically diagnosed as H‐SS
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Acantholytic PRIDE syndrome J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-11 Biswanath Behera, Ashish Kumar Nayak, Siddhartha Dash, Madhusmita Sethy, Pavithra Ayyanar
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Primary cutaneous EBV+ extranodal NK/T‐cell lymphoma of gamma/delta T‐cell lineage in the posttransplantation setting J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-11 Jessica F. Williams, Fabienne M. Lucas, Ruben D. Carrasco, Scott B. Lovitch, David C. Fisher, Thomas S. Kupper, Sam Sadigh
Posttransplantation primary cutaneous T‐cell lymphomas (PT‐CTCL) are a rare complication of sustained immunosuppression in the posttransplant setting. When present, PT‐CTCLs are typically EBV− and exhibit features of mycosis fungoides/Sézary syndrome or CD30+ lymphoproliferative disorders. We present a case of a 75‐year‐old individual who developed skin lesions 30 years after liver transplantation
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Toxic epidermal necrolysis‐like cutaneous toxicity following chimeric antigen receptor T‐cell therapy in recurrent large B‐cell lymphoma J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-10 Puneet K. Bhullar, Kiran Motaparthi, Daniel P. Zieman, Cassandra Johnson, Pooja Gurnani, Olayemi Sokumbi
Chimeric antigen receptor (CAR) T‐cell therapy has demonstrated remarkable success in treating various B‐cell malignancies, redirecting T‐cell cytotoxicity toward cancer cells. Despite its efficacy, CAR‐T therapy is associated with potential risks, including cytokine release syndrome (CRS) and cytopenia. We present a case of a 69‐year‐old man with diffuse large B‐cell lymphoma treated with axicabtagene‐ciloleucel
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A rare form of metastatic breast carcinoma mimicking lymphangioma circumscriptum J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-10 Zacaria Jr. B. Pario, Ma Flordeliz Abad‐Casintahan, Jonnie Rose Louise R. Wee, Melissa Rinne V. See, Karen Andrea D. Cadacio
Cutaneous metastasis is rare but may indicate an advanced internal malignancy or a recurrence of a previously treated one and is usually associated with a poor prognosis. They may also pose a diagnostic problem as the clinical manifestations are variable and non‐specific, which could mimic other benign conditions. We report a case of a 48‐year‐old female who presented with a 4‐year history of erythematous
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PRRX1‐fused mesenchymal neoplasm: A novel PRRX1::NCOA1 fusion transcript J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-10 Xiao Cheng, Jian Wang, Rong Fang, Jiayun Xu, Suying Wang, Ming Zhao
PRRX1‐fused mesenchymal neoplasm is a recently identified, rare subcutaneous soft tissue neoplasm that is characterized by fusion of PRRX1 (exon 1) with NCOA1 (exon 13) in the majority of reported cases. Although initially considered to be fibroblastic, a possibility of neural or neuroectodermal differentiation has been suggested in a subset of cases. We report a 26‐year‐old female with a 4.0 cm painless
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Immunophenotyping and viral studies in pityriasis lichenoides et varioliformis acuta lesions J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-08 Salih Mishlab, Emily Avitan‐Hersh, Yaniv Zohar, Moran Szwarcwort‐Cohen, Reuven Bergman
BackgroundThe underlying pathogenesis of pityriasis lichenoides et varioliformis acuta (PLEVA) remains unclear, although immunologic injury and viral etiology have been suggested.ObjectiveTo evaluate and expand the immunophenotype of PLEVA and to search for possible viral pathogens.MethodsFormalin‐fixed, paraffin‐embedded specimens of 20 patients with PLEVA and 9 patients with common inflammatory dermatoses
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Cover Image J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-08
The cover image is based on the Original Article Diagnostic discordance among histopathological reviewers of melanocytic lesions by Gregory A. Hosler et al., https://doi.org/10.1111/cup.14635.image
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Trainee perceptions of digital dermatopathology implementation at a multisite academic institution J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-05 Jacob P. Reinhart, Sydney L. Proffer, Jennifer L. Ridgeway, Barbara Barry, Celia Kamath, Erin Wissler Gerdes, Derek Cervenka, Margot S. Peters, Nneka I. Comfere, Emma F. Johnson, Carilyn N. Wieland
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Coexistence of large cell transformed mycosis fungoides and diffuse large B‐cell lymphoma in one patient J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-05 Thomas Z. Rohan, Jayson Suriano, Volkan Tekmen, Safiyyah Bhatti, Sahithi Talasila, Daniel Joffe, Caleb Holtmeyer, Jason B. Lee, Onder Alpdogan, Neda Nikbakht
Diffuse large B‐cell lymphoma (DLBCL) is the most common and aggressive subtype of non‐Hodgkin lymphoma. The overall risk of developing DLBCL is increased in patients with other lymphomas, such as mycosis fungoides (MF). In this report, we present an 81‐year‐old female with early‐stage MF who simultaneously progressed to tumor stage, large‐cell transformed (LCT) MF and developed a primary DLBCL in
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Asymptomatic CD34+ plaque on the scalp of a child J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-05 Tue F. Nguyen, Aeja Weiss, Emily Maxon, John C. Browning, Thomas Davis
Fibroblastic connective tissue nevus (FCTN) is a rare, benign dermal mesenchymal lesion of fibroblastic and myofibroblastic lineage. We report a case of a 2‐year‐old male who presented with an 18‐month history of an erythematous, asymptomatic, unchanging dermal plaque on the right medial frontal scalp. A punch biopsy showed a disorderly, bland, dermal fibroblastic spindle cell proliferation extending
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Determining the utility of IgA immunohistochemistry for the diagnosis of IgA vasculitis J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-07-01 Victoria Ricles, Madelyn M. Class, Vanden Lamar Grube, Lisa Zhai, Farhaan Hafeez
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A case of superficial acral fibromyxoma masquerading as squamous cell carcinoma of the thumb: A case report J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-28 Nadra S. Magtulis, Bryan Edgar K. Guevara
A wide spectrum of tumors may affect the periungual spaces of the digits. Superficial acral fibromyxoma (SAF) is a rare, benign soft tissue tumor with diverse clinical presentations. We present a case of a 55‐year‐old woman with a 2‐year history of a solitary periungual tumor on the left thumb, subjected to multiple episodes of trauma. Initially suspected to be a periungual squamous cell carcinoma
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Generalized lymphatic anomaly: A case report and review of literature J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-27 Eman R. M. Hofny, Asmaa M. Ahmed, Alaa Ghazally, Yasmin Salah, Ayman Mahran
Generalized lymphatic anomaly (GLA), previously known as lymphangiomatosis, is a rare developmental disease characterized by abnormal proliferation of lymphatic vascular structures that may involve the dermis, soft tissue, bone, and visceral parenchyma. Being an uncommon condition and the lack of specific symptoms often result in a delayed diagnosis or even misdiagnosis, which, in addition to its progressive
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Antiperspirant‐related zirconium and aluminum‐containing granulomas; histopathology and in situ chemical analysis J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-26 Jeffrey A. Sanford, Roberto Candelaria‐Santiago, Dominic M. Forte, Christian A. Curcio, Jill I. Allbritton, Stacy L. Strausborger, Michael R. Lewin‐Smith
The potential adverse health effects of antiperspirant use are of interest to patients, primary care providers, dermatologists, and pathologists. In rare instances, antiperspirants containing aluminum–zirconium complexes have been associated with granulomatous dermatoses despite being deemed non‐sensitizing in experiments. In this case study, we present a detailed examination of an axillary granuloma
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Squamous cell carcinoma of the nail apparatus: Histopathology and immunohistochemistry correlation study J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-22 Florine Moulart, Catherine Olemans, Nicolas de Saint Aubain, Bertrand Richert, Josette André
BackgroundNail squamous cell carcinoma (NSCC) is the most frequent ungual malignant tumor, but its incidence remains low. The histopathological description is sparse. We aim to characterize NSCC histopathological aspects, search for a correlation with clinical subtypes, and investigate immunohistochemistry expression of p16, p53, and Ki67.MethodsThis retrospective study collected NSCC diagnosed in
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Clinical implication of PRAME immunohistochemistry in differentiating melanoma in situ and dysplastic nevus in non‐acral nevus‐associated melanoma in situ: An institutional experience and meta‐analysis J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-21 Chau M. Bui, Huy Gia Vuong, Minh‐Khang Le, Josephine D'Angelo, Kathleen Mannava, Bruce R. Smoller
IntroductionPReferentially expressed Antigen in MElanoma (PRAME) has shown utility in differentiating benign from malignant melanocytic neoplasms. In this study, we investigated the clinical significance of PRAME expression in dysplastic nevi (DN) and nevus‐associated melanoma in situ (MIS).MethodsWe included 172 DN and 38 nevus‐associated MIS from our institutional archive. PRAME positive expression
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Ulcerated CRTC1::TRIM11 cutaneous tumor with metastases. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-15 Calvin Tseng,Erica C Koch Hein,Stephen M Smith,Ian King,Sam Saibil,Zaid Saeed Kamil
CRTC1::TRIM11 cutaneous tumor (CTCT) is a rare skin tumor of uncertain differentiation. In the 49 reported cases, only four cases showed regional or distant metastasis, but follow-up remains limited. Herein, we present a case of metastatic CTCT with ulceration, a histological feature that has not been previously described. A 75-year-old male with a 2-month history of toe ulceration underwent a shave
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Disseminated protothecosis: Case report and review of the literature. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-11 Safoura Shakoei,Farid Mohamadi,Fereshteh Ghiasvand,Ali Reza Khosravi,Kambiz Kamyab,Faeze Salahshour
BACKGROUND Human protothecosis is an uncommon infection caused by Prototheca spp that rarely infects humans. AIM Description of a rare disease and a review of its articles. MATERIALS AND METHODS We reported a 24-year-old man who presented with red-brown papules and plaques on the trunk's lateral side. We reviewed the literature about disseminated protothecosis and reported our experience with a patient
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Invasive squamous cell carcinoma within a plaque of circumscribed palmar hypokeratosis. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-08 Luis Araya,Celia Horcajada,Amalia Moreno,Jesús M Borbujo,Juan C Tardío
Circumscribed palmar hypokeratosis (CPH) is a localized disorder of epidermal keratinization that is presented as a well-delimited, depressed, erythematous plaque on the palms or on the soles. It is histopathologically characterized by an abrupt thinning of the corneal epidermal layer. CPH is considered a benign condition, but a few cases with dysplastic changes/carcinoma in situ in the hypokeratotic
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Extrafacial lentigo maligna: A progression model and enhanced diagnostic techniques using dermatoscopy and reflectance confocal microscopy. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-05 Joseph Griffiths Acha,Reyes Gamo Villegas,Uxua Floristán Murúzabal,Ana Pampín Franco,Claudia Sarró Fuente,Fernando Pinedo Moraleda,Jose Luis López Estebaranz
Lentigo maligna (LM) is a subtype of lentiginous melanoma confined to the epidermis, which is associated with chronic sun exposure. Its clinical, dermatoscopic, and histopathological diagnosis can be challenging, particularly in the early and advanced stages, requiring appropriate clinicopathological correlation. This article reviews the clinical presentation, diagnosis through noninvasive methods
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A case of diagnostic uncertainty: High-grade melanocytoma versus balloon cell melanoma in a pediatric patient. J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-06-04 Serena Shimshak,Olayemi Sokumbi,Ruifeng Guo,Dawn Marie R Davis,Katherine B Geiersbach,Nneka I Comfere
An 11-year-old female was referred from an outside institution after a diagnostic biopsy and subsequent excision of a progressively enlarging reddish-brown nodule demonstrated features concerning for a balloon cell nevus with severe atypia versus a high-grade melanocytoma. Upon review of the initial biopsy specimen and molecular data, we favored the diagnosis to be consistent with a high-grade melanocytoma
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Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review J. Cutan. Pathol. (IF 1.6) Pub Date : 2024-05-30 Grant Eilers, Richard C. Jordan
Paget disease is an intraepithelial neoplastic proliferation, commonly occurring in the breast and apocrine‐rich areas, often associated with an underlying internal malignancy. Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which were associated with an underlying internal malignancy. Here, we report a case of oral EMPD involving the