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Diagnostic challenge in veterinary pathology: Otitis in a humanized NOG-EXL mouse Vet. Pathol. (IF 2.3) Pub Date : 2024-09-21 Elinor Willis, Jillian Verrelle, Anthony Secreto, Stephen D. Cole, George McClung, Kelley M. Weinfurtner, Terence P.F. Gade, Enrico Radaelli
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Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia Vet. Pathol. (IF 2.3) Pub Date : 2024-09-19 Anna M. Meredith, Janet Beeler-Marfisi, Olaf Berke, Anthony J. Mutsaers, Dorothee Bienzle
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are heterogeneous neoplasms of hematopoietic stem cells that are challenging to diagnose, differentiate, and prognosticate. Cytogenetic and mutational analyses are useful in humans but unavailable for dogs, where diagnosis and classification still rely largely on hematologic and morphologic assessment. The objectives of this study were
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Intestinal pathology in goats challenged with Clostridium perfringens type D strain CN1020 wild-type and its genetically modified derivatives Vet. Pathol. (IF 2.3) Pub Date : 2024-09-18 Eleonora L. Morrell, Mauricio A. Navarro, Jorge P. Garcia, Juliann Beingesser, Francisco A. Uzal
Clostridium perfringens type D is the causative agent of enterotoxemia in sheep, goats, and cattle. Although in sheep and cattle, the disease is mainly characterized by neurological clinical signs and lesions, goats with type D enterotoxemia frequently have alterations of the alimentary system. Epsilon toxin (ETX) is the main virulence factor of C. perfringens type D, although the role of ETX in intestinal
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Evaluation of SOX-10 immunohistochemical expression in canine melanoma and non-melanocytic tumors by tissue microarray Vet. Pathol. (IF 2.3) Pub Date : 2024-09-06 Emily King, Matthew Cook, Hannah Wittorff, Wessel Dirksen, William C. Kisseberth, Ryan N. Jennings
Melanoma is the most common malignant oral tumor in dogs. It frequently presents a diagnostic challenge as many melanomas lack or contain scant melanin and may have a variable microscopic phenotype. Previous studies evaluating immunohistochemical markers for diagnosing melanoma have shown limited sensitivity and/or specificity for S-100, PNL2, melan A, TRP-1, TRP-2, and HMB-45. Sry-related HMG-box
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Image challenge in Veterinary Pathology, answers: Pulmonary diseases Vet. Pathol. (IF 2.3) Pub Date : 2024-09-02
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Splenic rupture in dairy cattle: Report of 24 cases Vet. Pathol. (IF 2.3) Pub Date : 2024-08-27 Vitor W. Horn, Fernanda F. Perosa, Anderson H. Gris, Manoela M. Piva, C. Robert Stilz, Érica Boldori, Mateus E. Gabriel, Giovana Pelisser, Saulo P. Pavarini, Teane M. A. Gomes, Ricardo E. Mendes
Splenic rupture in cattle is scarcely described in the literature. The aim of this work was to report the occurrence of splenic rupture in cattle in southern Brazil as well as to describe the causes of the condition. Between 2013 and 2022, 24 of the 1769 bovine necropsies performed in southern Brazil were due to splenic rupture, accounting for 1.36% of the diagnoses. Animals died due to hemoperitoneum
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Cytokeratin AE1/AE3 immunolabeling in epithelioid hemangiosarcoma Vet. Pathol. (IF 2.3) Pub Date : 2024-08-21 Daniel Felipe Barrantes Murillo, Tatiane Terumi Negrão Watanabe, Dominique J. Wiener, Andrew Miller, Daniel R. Rissi, Maninder Sandey
Epithelioid hemangiosarcoma (EH), a rare histological variant of hemangiosarcoma, is reported in various animal species, including humans, dogs, cows, horses, and cats. Epithelioid hemangiosarcomas are composed of highly pleomorphic epithelioid cells arranged in cords, islands, nests, or solid cellular areas, similar to epithelial neoplasms. Moreover, in humans, approximately 50% of EHs have cytoplasmic
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Letters or not, here we come! A communal perspective on credentials needed for a productive career in veterinary pathology. Vet. Pathol. (IF 2.3) Pub Date : 2024-08-20 Ingrid D Pardo,Ingeborg M Langohr,Phaedra Cole,Sue E Knoblaugh,Richard Luong,Keith Mansfield,Andres Mejia,Emily Meseck,Andrew D Miller,Kelley Penraat,Angela Pillatzki,Brad Bolon
Veterinary pathology credentials serve as a concise means attesting to educational attainments and experiences indicating a readiness for professional practice. Given the cost, time, and stress associated with obtaining different qualifications, pathologists must consider what credentials enhance their readiness. In this commentary, the authors describe how their various degrees and certifications
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Oral fibrolipoma in dogs: Retrospective case series study and comparative review Vet. Pathol. (IF 2.3) Pub Date : 2024-08-16 Daniel Felipe Barrantes Murillo, Alexis Berrocal, Cynthia Bell, Daniel R. Rissi, Linden E. Craig, Erin A. Graham, Emily J. Brinker, Tatiane Terumi Negrão Watanabe
Fibrolipoma is defined as a typical lipoma transected by variable amounts of paucicellular and collagenous fibrous components. Oral and lingual fibrolipomas are well-recognized histological entities in human medicine that are slightly more prevalent in females, occur most commonly after the fourth decade, and arise from the buccal mucosa. The documentation of this neoplasm in the oral cavity is lacking
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Testicular tumors in commercial boars with infertility: A gross, histologic, and immunohistochemical study Vet. Pathol. (IF 2.3) Pub Date : 2024-08-16 Raquel Ausejo, María Victoria Falceto, Olga Mitjana, Ana María Garrido, Juan José Badiola, Bernardino Moreno
Tumors in boars are uncommon, and testicular tumors even rarer. This study describes the pathological and immunohistochemical characteristics of a case series of testicular tumors in commercial boars with fertility problems. Tumors were detected in 19 of 333 animals (19/333, 5.9%). Macroscopically, tumors were observed in 13 (13/19, 68%) boars, while 6 cases (6/19, 32%) were only detected by microscopic
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Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi) Vet. Pathol. (IF 2.3) Pub Date : 2024-08-15 Simon Spiro, Marta Pereira, Kieran A. Bates, Zane Jaunmuktane, David J. Everest, Mark F. Stidworthy, Daniela Denk, Alejandro Núñez, Ethan Wrigglesworth, Andrew Theodoulou, Alberto Barbon, Emma Nye, Yan Liu, Adrian L. Smith, Steven Fiddaman
Polyglucosan bodies are accumulations of insoluble glucose polymers and proteins that form intracytoplasmic inclusions in the brain, large numbers of which can be indicative of neurodegenerative diseases such as Lafora disease. Montserrat orioles ( Icterus oberi) are an icterid passerine endemic to Montserrat with conservation populations maintained in captivity abroad. We demonstrate that polyglucosan
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Rosettes and pseudorosettes in veterinary neuropathology Vet. Pathol. (IF 2.3) Pub Date : 2024-08-14 Daniel R. Rissi, Andrew D. Miller
Rosettes and pseudorosettes are morphologic cell arrangements found in many neuroepithelial neoplasms in human medicine, including embryonal nervous system tumors (neuroblastoma, medulloblastoma, pineoblastoma, and retinoblastoma), non-embryonal nervous system tumors (ependymoma, astrocytoma, oligodendroglioma, and choroid plexus tumors), and other extraneural neuroepithelial neoplasms. Although these
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Review of spontaneous lesions in the exocrine pancreas of domestic ferrets (Mustela furo) Vet. Pathol. (IF 2.3) Pub Date : 2024-07-30 Sarah B. Sulkosky, Michael M. Garner, Mark Burgess, Bruce H. Williams, Elise E. B. LaDouceur
Large-scale retrospective studies allow for identification of disease trends, such as predisposing factors, typical clinical signs, and range of histologic lesions, which cannot be determined in individual case reports. Lesions of the endocrine pancreas of ferrets are extensively reported; however, there are no in-depth investigations of lesions in the exocrine pancreas. This retrospective analysis
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Histopathologic evaluation system of African swine fever in wild boar infected with high (Arm07) and low virulence (Lv17/WB/Riel) isolates Vet. Pathol. (IF 2.3) Pub Date : 2024-07-30 Néstor Porras, José M. Sánchez-Vizcaíno, José Á. Barasona, Alberto Gómez-Buendía, Estefanía Cadenas-Fernández, Antonio Rodríguez-Bertos
To understand the clinicopathological forms of African swine fever (ASF) in wild boar, it is crucial to possess a basic knowledge of the biological characteristics of the currently circulating ASF virus isolates. The aim of this work is to establish an accurate and comprehensive histopathologic grading system to standardize the assessment of the ASF lesions in wild boar. The study evaluated the differences
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Sarcomas of synovial origin in dogs: An updated review Vet. Pathol. (IF 2.3) Pub Date : 2024-07-28 Linden E. Craig
The purpose of this review is to clarify the terminology, possible cells of origin, and expected behavior of the most common synovial tumors in dogs. The synovial lining consists of 2 cell types, type A and type B. Type A synoviocytes are histiocytes of bone marrow origin that are immunoreactive with antibodies against typical markers of histiocyte origin, such as CD18, Iba-1, and CD204. Certain breeds
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Meningoencephalomyelitis and brachial plexitis in a dog infected with louping ill virus Vet. Pathol. (IF 2.3) Pub Date : 2024-07-26 Sai Fingerhood, Karen L. Mansfield, Arran J. Folly, Ana Gomez Vitores, Mara Rocchi, Dominic Clarke, Cecilia Gola
A foxhound from a hunting kennel in the United Kingdom was euthanized after being hospitalized with progressive neurologic signs, including tremors, seizures, and obtunded mentation. No abnormalities were appreciated on gross postmortem examination. Histologically, severe meningoencephalomyelitis and mild neuritis of the brachial plexus were present. Molecular analysis of brain tissue detected louping
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Book Review: Pathology of Pet and Aviary Birds Vet. Pathol. (IF 2.3) Pub Date : 2024-07-26 Richard Fulton
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Response to “Eponyms in science: A proposal to minimize their use” Vet. Pathol. (IF 2.3) Pub Date : 2024-07-24 Grant Maxie
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A brief history of the American College of Veterinary Pathologists (2009–2024) Vet. Pathol. (IF 2.3) Pub Date : 2024-07-24 Krista M. D. La Perle
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Image Challenge in Veterinary Pathology, Answers: Reproductive Tract Diseases Vet. Pathol. (IF 2.3) Pub Date : 2024-07-01
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Helicosporidium sp. infection in a California kingsnake (Lampropeltis californiae): Spillover of a pathogen of invertebrates to a vertebrate host. Vet. Pathol. (IF 2.3) Pub Date : 2024-06-16 Javier Asin,April L Childress,Eva Dervas,Michael M Garner,Francisco A Uzal,James F X Wellehan,Eileen E Henderson,Anibal G Armien
Helicosporidium is a genus of nonphotosynthetic, green algae in the family Chlorellaceae, closely related to Prototheca. It is a known pathogen of invertebrates, and its occurrence in vertebrates has not been documented. A captive, 10-month-old, male, albino California kingsnake (Lampropeltis californiae) was submitted for necropsy. Gross examination revealed hemorrhagic laryngitis and a red mottled
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Renal alterations in cats (Felis catus) housed in shelters and affected by systemic AA-amyloidosis: Clinicopathological data, histopathology, and ultrastructural features. Vet. Pathol. (IF 2.3) Pub Date : 2024-06-12 Filippo Ferri,Silvia Ferro,Silvia Lucia Benali,Luca Aresu,Lorenza Muscardin,Federico Porporato,Francesco Rossi,Chiara Guglielmetti,Enrico Gallo,Carlo Palizzotto,Carolina Callegari,Stefano Ricagno,Maria Mazza,Luigi Michele Coppola,Gabriele Gerardi,Francesca Lavatelli,Serena Caminito,Giulia Mazzini,Giovanni Palladini,Giampaolo Merlini,Eric Zini
AA-amyloidosis is frequent in shelter cats, and chronic kidney disease is the foremost cause of death. The aims were to describe kidney laboratory and microscopic findings in shelter cats with AA-amyloidosis. Cats were included if kidney specimens were collected post-mortem and laboratory data were available within 6 months before death. Renal lesions were evaluated with optical and electron microscopy
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Pathological findings and differential diagnoses of lymph node diseases in slaughtered cattle in Brazil: A study of 2000 samples. Vet. Pathol. (IF 2.3) Pub Date : 2024-06-11 Carlos E B Lopes,Fabiana G Xavier,Rafael R Nicolino,Luana F M Cordeiro,Leandro C Rezende,Marcelo C Lopes,Dayse H L Silva,Antônio A Fonseca Júnior,Luciana R Ferreira,Marcelo F Camargos,Paulo M Soares Filho,Ivy C C Souza,Roselene Ecco
Slaughterhouse inspections play a crucial role in the sanitary control of zoonoses and foodborne diseases. This study aimed to identify and analyze the frequencies of lymph node diseases in cattle slaughtered for human consumption, using the samples sent to the anatomic pathology service of the Federal Laboratory for Agricultural Defense (Laboratório Federal de Defesa Agropecuária), Minas Gerais, Brazil
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Effects of fixation and demineralization on histomorphology and DNA amplification of canine bone marrow. Vet. Pathol. (IF 2.3) Pub Date : 2024-06-06 Gabriella M L Diamantino,Janet Beeler-Marfisi,Robert A Foster,William Sears,Alice Defarges,William Vernau,Dorothee Bienzle
Fixation and demineralization protocols for bone marrow (BM) across diagnostic laboratories are not standardized. How different protocols affect histomorphology and DNA amplification is incompletely understood. In this study, 2 fixatives and 3 demineralization methods were tested on canine BM samples. Twenty replicate sternal samples obtained within 24 hours of death were fixed overnight in either
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Granulocytic neoplasm suggestive of primary myeloid sarcoma in 3 dogs. Vet. Pathol. (IF 2.3) Pub Date : 2024-06-06 Alessandra Ubiali,Valeria Martini,Stefano Comazzi,Selina Iussich,Barbara Miniscalco,Alessia Poggi,Emanuela Morello,Paola Roccabianca,Barbara Rütgen,Clarissa Zamboni,Fulvio Riondato
Myeloid sarcoma (MS) is a solid tumor of granulocytic origin with extramedullary localization. This tumor is rare in humans and animals. The diagnostic approach is heterogeneous, and the definitive diagnosis may be difficult to achieve. Primary MS has never been described as a spontaneous neoplasm in companion dogs. Two purebred and 1 mixed-breed dogs, 6- to 11-year-old, developed round cell tumors
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A putatively novel papillomavirus associated with cutaneous plaques and squamous cell carcinoma in captive North American snow leopards (Panthera uncia) Vet. Pathol. (IF 2.3) Pub Date : 2024-05-21 Mandy Womble, Shaina Weingart, Susan May, Michael Garner, Jennifer Luff
Cutaneous plaques and squamous cell carcinoma (SCC) are common in captive North American snow leopards (SLs) ( Panthera uncia). Our objective was to determine whether these lesions are potentially associated with papillomavirus(es). Polymerase chain reaction (PCR) was performed on 3 cutaneous plaques using degenerate primers for papillomaviruses. A putatively novel papillomavirus was identified that
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Neurobrucellosis (Brucella ceti) in striped dolphins (Stenella coeruleoalba): Immunohistochemical studies on immune response and neuroinflammation Vet. Pathol. (IF 2.3) Pub Date : 2024-05-18 Agustín Rebollada-Merino, Federica Giorda, Martí Pumarola, Laura Martino, Alberto Gomez-Buendia, Umberto Romani-Cremaschi, Cristina Casalone, Virginia Mattioda, Fabio Di Nocera, Giuseppe Lucifora, Antonio Petrella, Lucas Domínguez, Mariano Domingo, Carla Grattarola, Antonio Rodríguez-Bertos
Neurobrucellosis is a shared condition of cetaceans and humans. However, the pathogenesis and immune response in cetacean neurobrucellosis has not been extensively studied. In this multicentric investigation, 21 striped dolphin ( Stenella coeruleoalba) neurobrucellosis ( Brucella ceti) cases diagnosed over a 10-year period (2012-2022) were retrospectively evaluated. For each case, morphological changes
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Pneumocystis murina lesions in lungs of experimentally infected Cd40l–/– mice Vet. Pathol. (IF 2.3) Pub Date : 2024-05-17 Andrea Cappelleri, Simone Canesi, Luca Bertola, Valentina Capo, Alessandra Zecchillo, Luisa Albano, Anna Villa, Eugenio Scanziani, Camilla Recordati
The Cd40l–/– mouse is a well-established model of X-linked hyper-immunoglobulin M (IgM) syndrome, an immunodeficiency disorder of human beings characterized by the lack of expression of the CD40 ligand (CD40L) on activated T-cells, predisposing to infections with opportunistic pathogens like Pneumocystis jirovecii. The aim of our study was to describe the pulmonary lesions in Cd40l–/– mice experimentally
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“Errata” does anyone read them? Revisiting mitotic counts in mast cell tumors Vet. Pathol. (IF 2.3) Pub Date : 2024-05-14 Donald J. Meuten, Frances M. Moore, Phil H. Kass, Cheryl A. London, Christopher M. Reilly, Erin M. Romansik, Felipe A. R. Sueiro
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Eponyms in science: A proposal to minimize their use Vet. Pathol. (IF 2.3) Pub Date : 2024-05-10 F. Yvonne Schulman, Daniel R. Rissi
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Survivin, β-catenin, and ki-67 immunohistochemical expression in canine perivascular wall tumors: Preliminary assessment of prognostic significance Vet. Pathol. (IF 2.3) Pub Date : 2024-05-10 Francesco Godizzi, Federico Armando, Patrizia Boracchi, Giancarlo Avallone, Damiano Stefanello, Roberta Ferrari, Lavinia E. Chiti, Andrea Cappelleri, Clarissa Zamboni, Silvia Dell’Aere, Attilio Corradi, Paola Roccabianca
High survivin expression has been correlated with poor outcomes in several canine tumors but not in soft tissue tumors (STTs). Survivin is a target gene of the Wnt/β-catenin pathway, which is involved in human STT oncogenesis. Immunohistochemistry for survivin, β-catenin, and Ki-67 was performed on 41 canine perivascular wall tumors (cPWTs), and statistical associations of protein expression and histopathologic
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Short beak and dwarfism syndrome among Pekin ducks: First detection, full genome sequencing, and immunohistochemical signals of novel goose parvovirus in tongue tissue Vet. Pathol. (IF 2.3) Pub Date : 2024-05-07 Amal A. M. Eid, Mohamed A. Lebdah, Sarah S. Helal, Mohamed G. Seadawy, Abdelgalil El-Gohary, Mohamed R. Mousa, Ayman H. El-Deeb, Fakry F. Mohamed, Reham M. ElBakrey
Novel goose parvovirus (NGPV) is continuously threatening the global duck industry, as it causes short beak and dwarfism syndrome among different duck breeds. In this study, we investigated the viral pathogenesis in the tongue of affected ducks, as a new approach for deeper understanding of the syndrome. Seventy-three, 14- to 60-day-old commercial Pekin ducks were clinically examined. Thirty tissue
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Image challenge in Veterinary Pathology answers: Dermatopathology Vet. Pathol. (IF 2.3) Pub Date : 2024-05-03
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Postmortem pathologic findings in dogs that underwent total body irradiation and hematopoietic cell transplant: A case series of five dogs with B-cell multicentric lymphoma Vet. Pathol. (IF 2.3) Pub Date : 2024-05-02 William Benedict, Steven Suter, Danielle Meritet
Alternative therapies that can help achieve complete remission in dogs with lymphoma include total body irradiation and hematopoietic cell transplant, though there are few reports describing successes and pathologic sequelae of these procedures. During a 10-year period, 94 dogs with multicentric lymphoma received a hematopoietic cell transplant following total body irradiation at North Carolina State
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Corrigendum to mitotic index is predictive for survival for canine cutaneous mast cell tumors Vet. Pathol. (IF 2.3) Pub Date : 2024-05-02
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Intramural coronary artery and myocardial pathology in captive tigers (Panthera tigris) and African lions (Panthera leo) Vet. Pathol. (IF 2.3) Pub Date : 2024-04-25 Rebecca L. Makii, Juan Muñoz Gutiérrez
There is limited published data regarding cardiovascular disease in nondomestic felid populations. To address this knowledge gap, necropsy cases of tigers and lions with representative myocardial samples submitted to a diagnostic laboratory were histologically assessed with hematoxylin and eosin and Sirius red stains. A total of 32 submissions (15 tigers, 17 lions) were identified in a 4-year period
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Tumor-associated macrophages and tumor-infiltrating lymphocytes in canine cutaneous and subcutaneous mast cell tumors Vet. Pathol. (IF 2.3) Pub Date : 2024-04-22 Luca Bertola, Benedetta Pellizzoni, Chiara Giudice, Valeria Grieco, Roberta Ferrari, Lavinia E. Chiti, Damiano Stefanello, Martina Manfredi, Donatella De Zani, Camilla Recordati
Cutaneous and subcutaneous mast cell tumors (MCTs) are common canine neoplasms characterized by variable biological behavior. Tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) can be effective prognostic markers in numerous human neoplasms and are increasingly investigated in dogs. The aim of this study was to characterize immune cells in canine MCTs and their relationship
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Melan-A immunolabeling in canine extramedullary plasmacytomas Vet. Pathol. (IF 2.3) Pub Date : 2024-04-20 Lukas Schuwerk, Anastasiia Ulianytska, Wolfgang Baumgärtner, Wencke Reineking
Histologic diagnosis of less well-differentiated cases of canine extramedullary plasmacytomas (CEMPs) may require immunohistochemical confirmation to discriminate these tumors from other round cells tumors including lymphoma, cutaneous histiocytoma, and amelanotic melanomas. CEMPs are characterized by widespread immunoreactivity for multiple myeloma 1 (MUM1) antigen and λ light chains, while the melanocytic
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Tissue and cellular tropism of Eptesicus fuscus gammaherpesvirus in big brown bats, potential role of pulmonary intravascular macrophages Vet. Pathol. (IF 2.3) Pub Date : 2024-04-15 Ursula G. Perdrizet, Janet E. Hill, LaRhonda Sobchishin, Baljit Singh, Champika Fernando, Trent K. Bollinger, Vikram Misra
Gammaherpesviruses (γHVs) are recognized as important pathogens in humans but their relationship with other animal hosts, especially wildlife species, is less well characterized. Our objectives were to examine natural Eptesicus fuscus gammaherpesvirus (EfHV) infections in their host, the big brown bat ( Eptesicus fuscus), and determine whether infection is associated with disease. In tissue samples
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Hypoxia-associated markers in the prognosis of oral canine melanoma Vet. Pathol. (IF 2.3) Pub Date : 2024-04-13 Cecilia Gola, Lorella Maniscalco, Selina Iussich, Emanuela Morello, Matteo Olimpo, Eugenio Martignani, Paolo Accornero, Davide Giacobino, Eugenio Mazzone, Paola Modesto, Katia Varello, Luca Aresu, Raffaella De Maria
Canine oral malignant melanoma (COMM) is the most common neoplasm in the oral cavity characterized by local invasiveness and high metastatic potential. Hypoxia represents a crucial feature of the solid tumor microenvironment promoting cancer progression and drug resistance. Hypoxia-inducible factor-1α (HIF-1α) and its downstream effectors, vascular endothelial growth factor A (VEGF-A), glucose transporter
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ORF virus causes tumor-promoting inflammation in sheep and goats Vet. Pathol. (IF 2.3) Pub Date : 2024-04-13 Davide Pintus, Maria G. Cancedda, Giantonella Puggioni, Rosario Scivoli, Angela M. Rocchigiani, Caterina Maestrale, Elisabetta Coradduzza, Roberto Bechere, Luciana Silva-Flannery, Hannah A. Bullock, Simona Macciocu, Maria A. Montesu, Vincenzo Marras, Simone Dore, Jana M. Ritter, Ciriaco Ligios
ORF virus (ORFV) causes contagious ecthyma (“ORF”), a disease of sheep and goats characterized by lesions ranging from vesicles and pustules to atypical papilloma-like and angiomatous lesions in the skin and mucosae. The authors investigated the molecular factors leading to the ORF-associated atypical tumor-like changes. Fifteen lambs, 15 kids, and an adult ram clinically affected by natural ORFV infection
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SOX-10 and TRP-1 expression in feline ocular and nonocular melanomas Vet. Pathol. (IF 2.3) Pub Date : 2024-04-13 Margherita Orlandi, Ilaria Porcellato, Monica Sforna, Adriana Lo Giudice, Giuseppe Giglia, Luca Mechelli, Chiara Brachelente
In felines, ocular and nonocular melanomas are uncommon tumors that represent a diagnostic challenge for pathologists, especially when amelanotic. To date, the immunohistochemical diagnostic panel in cats is based on specific melanocytic markers (Melan-A and PNL2) and a nonspecific but sensitive marker (S100). In human medicine, SOX-10 is reported to be a sensitive antibody for the detection of melanoma
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The relationships of platelet-derived growth factor, microvascular proliferation, and tumor cell proliferation in canine high-grade oligodendrogliomas: Immunohistochemistry of 45 tumors and an AFOB-01 xenograft mouse model Vet. Pathol. (IF 2.3) Pub Date : 2024-04-05 Kio Yoshida, James K. Chambers, Kazuyuki Uchida
High-grade oligodendroglioma (HGOG) is the most common type of glioma in dogs and expresses platelet-derived growth factor receptor-α (PDGFR-α). Microvascular proliferation is often observed in HGOG. Therefore, the present study investigated the functional relationships between PDGFR-α, microvascular proliferation, and tumor cell proliferation in canine HGOG. The expression of PDGFR-α and PDGF-subunit
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The 2-tier grading system identifies canine cutaneous and/or subcutaneous mast cell tumors with aggressive biological behavior regardless of growth model Vet. Pathol. (IF 2.3) Pub Date : 2024-04-05 Silvia Sabattini, Alessia Brocanelli, Riccardo Zaccone, Eugenio Faroni, Andrea Renzi, Luca Ciammaichella, Giuliano Bettini, Laura Marconato
Histologic grading of canine cutaneous mast cell tumors (cMCTs) has prognostic and therapeutic implications, yet validation for subcutaneous MCTs (scMCTs) is lacking. For scMCTs with or without dermal invasion, determining their biological behavior remains poorly standardized and sometimes sparks controversy. This prospective study aimed to assess the prognostic utility of the 2-tier histologic grading
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Pathology of “double scale” skin defect in farmed American alligators (Alligator mississippiensis) and the possible association with hepatic fibrosis Vet. Pathol. (IF 2.3) Pub Date : 2024-03-29 Ilaria M. Piras, Annemarie Bezuidenhout, Josué Díaz-Delgado, Deirdre Slawski, Pamela A. Kelly
“Double scale” is a poorly characterized skin defect of crocodilians that drastically reduces the economic value of crocodilian skin. This study investigated the morphology and pathogenesis of double scale in a ranching farm of American alligators ( Alligator mississippiensis). We compared the histopathology of skin and selected organs (liver, lung, kidney, heart, spleen, intestine, and brain) of alligators
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Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors Vet. Pathol. (IF 2.3) Pub Date : 2024-03-27 Christof A. Bertram, Taryn A. Donovan, Alexander Bartel
One of the most relevant prognostic indices for tumors is cellular proliferation, which is most commonly measured by the mitotic activity in routine tumor sections. The goal of this systematic review was to analyze the methods and prognostic relevance of histologically measuring mitotic activity that have been reported for canine tumors in the literature. A total of 137 articles that correlated the
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Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors Vet. Pathol. (IF 2.3) Pub Date : 2024-03-27 Christof A. Bertram, Taryn A. Donovan, Alexander Bartel
Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to provide an overview of the assessment methods and prognostic value. A systematic literature search in PubMed and Scopus and a nonsystematic search in Google Scholar
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Diagnostic challenge in veterinary pathology: Bony elbow mass in a domestic ferret Vet. Pathol. (IF 2.3) Pub Date : 2024-03-15 Judith A. Kovach-Zukin, Joyce S. Knoll, Andrew Cartoceti, Robert A. Foster, Marina Liles, Julianne Richard, Elizabeth Marie Rush, Elise E. B. LaDouceur
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Embolic necrosuppurative pneumonia in domestic cats induced by a novel Neisseria species Vet. Pathol. (IF 2.3) Pub Date : 2024-03-05 Christopher R. Bolt, Vikash K. Singh, Arno Wünschmann, Hallie C. Richards, Kelly L. Gehlhaus, Sunil K. Mor
Three cats, aged 2 to 11 years, presented to the University of Minnesota Veterinary Diagnostic Laboratory over a 3-year period following euthanasia or death due to respiratory distress. Thoracic radiographs revealed nodular, soft tissue opacities throughout the lung fields in all cases. On postmortem examination, approximately 60% to 80% of the lung parenchyma were expanded by multifocal to coalescing
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Mannheimia haemolytica–associated fibrinonecrotizing abomasitis in lambs Vet. Pathol. (IF 2.3) Pub Date : 2024-03-05 Estela Pérez, Francisco A. Uzal, Ricardo de Miguel, Ana Rodríguez-Largo, Raúl Reséndiz, Nicolás Streitenberger, Melissa Macías-Rioseco, Álex Gómez, Natalia Calvo-Sánchez, Marta Pérez, Lluís Luján, Javier Asín
Mannheimia haemolytica–associated abomasitis has been clinically described as a cause of sudden death in lambs, but it is poorly characterized. We describe the pathological features of a severe fibrinonecrotizing abomasitis in 3 lambs that died suddenly. All 3 abomasums had a thickened submucosa due to edema and necrotic areas delimited by bands of degenerate neutrophils with slender nuclei (oat cells)
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Experimental oral administration of pollen beetle (Astylus atromaculatus) to cattle results in an acute lethal gastrointestinal disease Vet. Pathol. (IF 2.3) Pub Date : 2024-03-04 Federico Giannitti, Mizael Machado, Caroline da Silva Silveira, Ximena Cibils-Stewart, Nicolás Baráibar, Cintia R. R. Queiroz-Machado, Robert H. Poppenga, Alejo Menchaca, Francisco A. Uzal, Juan A. García, Carolina Matto, Fernando Dutra, Gretel Ruprechter, Darío Caffarena, Anderson Saravia
In the summer of 2023, ingestion of Astylus atromaculatus (pollen beetle) was linked to spontaneous fatal disease in grazing cattle and sheep in Argentina and Uruguay. While the disease was experimentally reproduced in sheep and guinea pigs in the 1970’s, no experimental reproductions have been attempted in cattle, and controversy exists as to whether this insect is indeed noxious to cattle and at
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Macrophage polarization in lymph node granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex Vet. Pathol. (IF 2.3) Pub Date : 2024-03-01 Fernanda Larenas-Muñoz, Mohamed G. Hamed, Inés Ruedas-Torres, José María Sánchez-Carvajal, Javier Domínguez, Francisco José Pallarés, Librado Carrasco, Irene M. Rodríguez-Gómez, Jaime Gómez-Laguna
Tuberculosis in animals is caused by members of the Mycobacterium tuberculosis complex (MTC), with the tuberculous granuloma being the main characteristic lesion. The macrophage is the main cell type involved in the development of the granuloma and presents a wide plasticity ranging from polarization to classically activated or pro-inflammatory macrophages (M1) or to alternatively activated or anti-inflammatory
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Experimental infection of domestic turkeys with lymphoproliferative disease virus of North American origin Vet. Pathol. (IF 2.3) Pub Date : 2024-02-28 Chloe C. Goodwin, Kayla G. Adcock, Andrew B. Allison, Mark G. Ruder, Rebecca L. Poulson, Nicole M. Nemeth
Lymphoproliferative disease virus (LPDV) was first documented in wild turkeys in North America in 2009. LPDV infection is often subclinical but can manifest as lymphoid proliferation or round cell neoplasia. Despite high prevalence across many sampled areas corresponding to declining populations of wild turkeys, knowledge regarding LPDV pathogenesis, risk factors for disease development, and associated
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Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins Vet. Pathol. (IF 2.3) Pub Date : 2024-02-17 Sophie Nelissen, Andrew D. Miller
Several members of the SRY-related HMG-box (SOX) protein family are implicated in tumorigenesis, metastasis, and regulation of the tumor microenvironment. SOX10, which is involved in neural crest cell migration and differentiation, has long been recognized a sensitive and specific immunohistochemical (IHC) marker in the diagnosis of melanoma in humans. However, expression of SOX10 in other tumor types
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Eptesipox virus-associated lesions in naturally infected big brown bats Vet. Pathol. (IF 2.3) Pub Date : 2024-02-17 Ursula G. Perdrizet, Janet E. Hill, Champika Fernando, LaRhonda Sobchishin, Vikram Misra, Trent K. Bollinger
Bats have many unique qualities amongst mammals; one of particular importance is their reported tolerance to viruses without developing disease. Here, the authors present evidence to the contrary by describing and demonstrating viral nucleic acids within lesions from eptesipox virus (EfPV) infection in big brown bats. One hundred and thirty bats submitted for necropsy from Saskatchewan, Canada, between
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Diagnostic challenge in veterinary pathology: Mandibular mass in a cow. Vet. Pathol. (IF 2.3) Pub Date : 2024-02-12 Gabrita De Zan,Claudia Zanardello,Andrea Cittaro,Marilena Boscarato,Alessia Rizzardi,Nadia Genero,Monia Cocchi