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Diagnostic challenge in veterinary pathology: Bony elbow mass in a domestic ferret Vet. Pathol. (IF 2.4) Pub Date : 2024-03-15 Judith A. Kovach-Zukin, Joyce S. Knoll, Andrew Cartoceti, Robert A. Foster, Marina Liles, Julianne Richard, Elizabeth Marie Rush, Elise E. B. LaDouceur
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Embolic necrosuppurative pneumonia in domestic cats induced by a novel Neisseria species Vet. Pathol. (IF 2.4) Pub Date : 2024-03-05 Christopher R. Bolt, Vikash K. Singh, Arno Wünschmann, Hallie C. Richards, Kelly L. Gehlhaus, Sunil K. Mor
Three cats, aged 2 to 11 years, presented to the University of Minnesota Veterinary Diagnostic Laboratory over a 3-year period following euthanasia or death due to respiratory distress. Thoracic radiographs revealed nodular, soft tissue opacities throughout the lung fields in all cases. On postmortem examination, approximately 60% to 80% of the lung parenchyma were expanded by multifocal to coalescing
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Mannheimia haemolytica–associated fibrinonecrotizing abomasitis in lambs Vet. Pathol. (IF 2.4) Pub Date : 2024-03-05 Estela Pérez, Francisco A. Uzal, Ricardo de Miguel, Ana Rodríguez-Largo, Raúl Reséndiz, Nicolás Streitenberger, Melissa Macías-Rioseco, Álex Gómez, Natalia Calvo-Sánchez, Marta Pérez, Lluís Luján, Javier Asín
Mannheimia haemolytica–associated abomasitis has been clinically described as a cause of sudden death in lambs, but it is poorly characterized. We describe the pathological features of a severe fibrinonecrotizing abomasitis in 3 lambs that died suddenly. All 3 abomasums had a thickened submucosa due to edema and necrotic areas delimited by bands of degenerate neutrophils with slender nuclei (oat cells)
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Experimental oral administration of pollen beetle (Astylus atromaculatus) to cattle results in an acute lethal gastrointestinal disease Vet. Pathol. (IF 2.4) Pub Date : 2024-03-04 Federico Giannitti, Mizael Machado, Caroline da Silva Silveira, Ximena Cibils-Stewart, Nicolás Baráibar, Cintia R. R. Queiroz-Machado, Robert H. Poppenga, Alejo Menchaca, Francisco A. Uzal, Juan A. García, Carolina Matto, Fernando Dutra, Gretel Ruprechter, Darío Caffarena, Anderson Saravia
In the summer of 2023, ingestion of Astylus atromaculatus (pollen beetle) was linked to spontaneous fatal disease in grazing cattle and sheep in Argentina and Uruguay. While the disease was experimentally reproduced in sheep and guinea pigs in the 1970’s, no experimental reproductions have been attempted in cattle, and controversy exists as to whether this insect is indeed noxious to cattle and at
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Macrophage polarization in lymph node granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex Vet. Pathol. (IF 2.4) Pub Date : 2024-03-01 Fernanda Larenas-Muñoz, Mohamed G. Hamed, Inés Ruedas-Torres, José María Sánchez-Carvajal, Javier Domínguez, Francisco José Pallarés, Librado Carrasco, Irene M. Rodríguez-Gómez, Jaime Gómez-Laguna
Tuberculosis in animals is caused by members of the Mycobacterium tuberculosis complex (MTC), with the tuberculous granuloma being the main characteristic lesion. The macrophage is the main cell type involved in the development of the granuloma and presents a wide plasticity ranging from polarization to classically activated or pro-inflammatory macrophages (M1) or to alternatively activated or anti-inflammatory
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Experimental infection of domestic turkeys with lymphoproliferative disease virus of North American origin Vet. Pathol. (IF 2.4) Pub Date : 2024-02-28 Chloe C. Goodwin, Kayla G. Adcock, Andrew B. Allison, Mark G. Ruder, Rebecca L. Poulson, Nicole M. Nemeth
Lymphoproliferative disease virus (LPDV) was first documented in wild turkeys in North America in 2009. LPDV infection is often subclinical but can manifest as lymphoid proliferation or round cell neoplasia. Despite high prevalence across many sampled areas corresponding to declining populations of wild turkeys, knowledge regarding LPDV pathogenesis, risk factors for disease development, and associated
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Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins Vet. Pathol. (IF 2.4) Pub Date : 2024-02-17 Sophie Nelissen, Andrew D. Miller
Several members of the SRY-related HMG-box (SOX) protein family are implicated in tumorigenesis, metastasis, and regulation of the tumor microenvironment. SOX10, which is involved in neural crest cell migration and differentiation, has long been recognized a sensitive and specific immunohistochemical (IHC) marker in the diagnosis of melanoma in humans. However, expression of SOX10 in other tumor types
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Eptesipox virus-associated lesions in naturally infected big brown bats Vet. Pathol. (IF 2.4) Pub Date : 2024-02-17 Ursula G. Perdrizet, Janet E. Hill, Champika Fernando, LaRhonda Sobchishin, Vikram Misra, Trent K. Bollinger
Bats have many unique qualities amongst mammals; one of particular importance is their reported tolerance to viruses without developing disease. Here, the authors present evidence to the contrary by describing and demonstrating viral nucleic acids within lesions from eptesipox virus (EfPV) infection in big brown bats. One hundred and thirty bats submitted for necropsy from Saskatchewan, Canada, between
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Apolipoprotein C-III amyloidosis in white lions (Panthera leo) Vet. Pathol. (IF 2.4) Pub Date : 2024-02-12 Natsumi Kobayashi, Susumu Iwaide, Hiroto Fukui, Yumi Une, Yoshiyuki Itoh, Miki Hisada, Tomoaki Murakami
Apolipoprotein C-III (ApoC-III) amyloidosis in humans is a hereditary amyloidosis caused by a D25V mutation in the APOC3 gene. This condition has only been reported in a French family and not in animals. We analyzed a 19-year-old white lion ( Panthera leo) that died in a Japanese safari park and found renal amyloidosis characterized by severe deposition confined to the renal corticomedullary border
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High-mortality epizootic Mycobacterium ulcerans ecovar Liflandii in a colony of Zaire Dwarf Clawed Frogs (Hymenochirus boettgeri) Vet. Pathol. (IF 2.4) Pub Date : 2024-02-12 Matthew Boulanger, Marcus J. Crim, Jill Keller, Mark J. Hoenerhoff
Mycobacterium ulcerans ecovar Liflandii ( MuLiflandii) was identified as the causative agent of mycobacteriosis in a research colony of Zaire dwarf clawed frogs ( Hymenochirus boettgeri) at the University of Michigan. Clinical presentation included lethargy, generalized septicemia, cutaneous granulomas, coelomic effusion, and acute mortality. Identification of the mycobacterial species was based on
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Mortality associated with SARS-CoV-2 in nondomestic felids Vet. Pathol. (IF 2.4) Pub Date : 2024-02-07 Mary Drozd, Jana M. Ritter, Jonathan Peter Samuelson, Maryanna Parker, Leyi Wang, Samantha J. Sander, Jill Yoshicedo, Louden Wright, Jenee Odani, Trent Shrader, Elizabeth Lee, Shawn R. Lockhart, Ria R. Ghai, Karen A. Terio
Between September and November 2021, 5 snow leopards ( Panthera uncia) and 1 lion ( Panthera leo) were naturally infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) and developed progressive respiratory disease that resulted in death. Severe acute respiratory syndrome coronavirus 2 sequencing identified the delta variant in all cases sequenced, which was the predominant human variant
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PD-L1 mRNA and protein expression in canine mammary carcinomas: Correlation with histopathological grade and molecular markers Vet. Pathol. (IF 2.4) Pub Date : 2024-01-28 Min-Kyung Bae, Yeong-Ung Ko, Byung-Joon Seung, Jung-Hyang Sur, Nong-Hoon Choe
Programmed death ligand 1 (PD-L1) is an immune checkpoint molecule that plays a crucial role in regulating antitumor immune responses. Canine mammary carcinomas (CMCs) are common tumors of dogs. Despite extensive studies on the heterogeneity of CMCs, there is still a lack of effective precision therapies for the treatment of CMCs. In this study, we aimed to investigate the correlation between PD-L1
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Immunohistochemical characterization of the immune cell response during chlamydial infection in the male and female koala (Phascolarctos cinereus) reproductive tract Vet. Pathol. (IF 2.4) Pub Date : 2024-01-19 Sara Pagliarani, Stephen D. Johnston, Kenneth W. Beagley, Chiara Palmieri
Chlamydiosis is one of the main causes of the progressive decline of koala populations in eastern Australia. While histologic, immunologic, and molecular studies have provided insights into the basic function of the koala immune system, the in situ immune cell signatures during chlamydial infection of the reproductive tract in koalas have not been investigated. Thirty-two female koalas and 47 males
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Prognostic impact of Ki-67 in canine splenic hemangiosarcoma: A preliminary study Vet. Pathol. (IF 2.4) Pub Date : 2024-01-12 Elena Brigandì, Paola Valenti, Barbara Bacci, Barbara Brunetti, Giancarlo Avallone
Canine splenic hemangiosarcoma has a high metastatic rate and short survival time. Currently, the main prognostic parameters are tumor stage and therapy, while data on histologic parameters, such as grade and Ki-67 expression, are scarce. The aims of this study were to compare two methods of assessment of Ki-67, verify their prognostic impact, and define a threshold value based on survival. Thirty-one
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Swine models in translational research and medicine Vet. Pathol. (IF 2.4) Pub Date : 2024-01-10 David K. Meyerholz, Eric R. Burrough, Nicole Kirchhof, Douglas J. Anderson, Kristi L. Helke
Swine are increasingly studied as animal models of human disease. The anatomy, size, longevity, physiology, immune system, and metabolism of swine are more like humans than traditional rodent models. In addition, the size of swine is preferred for surgical placement and testing of medical devices destined for humans. These features make swine useful for biomedical, pharmacological, and toxicological
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Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice Vet. Pathol. (IF 2.4) Pub Date : 2024-01-10 Elinor Willis, Jillian Verrelle, Esha Banerjee, Charles-Antoine Assenmacher, James C. Tarrant, Nicholas Skuli, Moriah L. Jacobson, Donald M. O’Rouke, Zev A. Binder, Enrico Radaelli
NSG-SGM3 and NOG-EXL mice combine severe immunodeficiency with transgenic expression of human myeloid stimulatory cytokines, resulting in marked expansion of myeloid populations upon humanization with CD34+ hematopoietic stem cells (HSCs). Humanized NSG-SGM3 mice typically develop a lethal macrophage activation syndrome and mast cell hyperplasia that limit their use in long-term studies (e.g., humanization
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Lesions and viral antigen distribution in bald eagles, red-tailed hawks, and great horned owls naturally infected with H5N1 clade 2.3.4.4b highly pathogenic avian influenza virus Vet. Pathol. (IF 2.4) Pub Date : 2024-01-10 Arno Wünschmann, Dana Franzen-Klein, Mia Torchetti, Michele Confeld, Michelle Carstensen, Victoria Hall
An epidemic of highly pathogenic avian influenza (HPAI) began in North America in the winter of 2021. The introduced Eurasian H5N1 clade 2.3.4.4b virus subsequently reassorted with North American avian influenza strains. This postmortem study describes the lesions and influenza A virus antigen distribution in 3 species of raptors, including bald eagles ( Haliaeetus leucocephalus, n = 6), red-tailed
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Pyrethroid-associated nephrotoxicity in channel catfish, Ictalurus punctatus, and blue catfish, I. furcatus, at a public aquarium Vet. Pathol. (IF 2.4) Pub Date : 2024-01-09 Justin M. Stilwell, Sean M. Perry, Lora Petrie-Hanson, Rachel Sheffler, John P. Buchweitz, Alexa J. Delaune
Over the course of an approximately 11-month period, an outdoor, freshwater, mixed species, recirculating, display system at a public aquarium experienced intermittent mortalities of channel catfish ( Ictalurus punctatus) and blue catfish ( I. furcatus). Catfish acutely presented for abnormal buoyancy, coelomic distention, and protein-rich coelomic effusion. Gross lesions typically involved massive
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Image challenge in Veterinary Pathology, answers: Ultrastructural pathology. Vet. Pathol. (IF 2.4) Pub Date : 2024-01-01
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Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses. Vet. Pathol. (IF 2.4) Pub Date : 2023-11-29 Mason C Jager,Eunju Choi,Joy E Tomlinson,Gerlinde Van de Walle
Equine parvovirus-hepatitis (EqPV-H) is the causative agent of Theiler's disease, or severe acute hepatic necrosis, in horses. However, it is poorly understood whether EqPV-H is associated with other histologic findings in horses with clinical liver disease. The objective of this study was to examine the prevalence and severity of EqPV-H infections in diagnostic liver samples. Archived formalin-fixed
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Neoplasia in an assurance population of Puerto Rican crested toads (Peltophryne lemur). Vet. Pathol. (IF 2.4) Pub Date : 2023-11-28 Sierra M Imanse,Caitlin E Burrell,Sarah A Cannizzo,Tara S Reilly,Kimberly L Rainwater,Martha A Delaney
Disease monitoring of amphibian assurance populations is an important buffer against ongoing global extinctions. This study documents a high incidence of neoplasia in a zoo-managed assurance population of Puerto Rican crested toads (Peltophryne lemur; PRCTs). Over 5 years, neoplasia was diagnosed in 17/49 (35%) submitted adult PRCTs and was the cause of death or euthanasia in 13/17 (72%). Most toads
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Aneurysm Associated with Vascular Wall Degeneration in Bearded Dragons (Pogona vitticeps). Vet. Pathol. (IF 2.4) Pub Date : 2023-11-25 Joaquín Ortega,Jeanette Wyneken,Michael M Garner
This study describes the clinical, gross, and histologic findings in 17 cases of aneurysms in bearded dragons (Pogona vitticeps). The clinical presentation ranged from incidental to sudden and unexpected death. The affected vasculature was predominantly arterial; however, based on the topographical locations of the lesions, gross structure, and drainage, some veins were likely involved. Magnetic resonance
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Diversity of mutations in the dystrophin gene and details of muscular lesions in porcine dystrophinopathies. Vet. Pathol. (IF 2.4) Pub Date : 2023-11-25 Yumiko Kamiya,Naoyuki Aihara,Takanori Shiga,Noriyuki Horiuchi,Junichi Kamiie
During meat inspections in pigs, dystrophinopathies are among the muscle lesions targeted for disposal. In this study, the authors examined the lesions and the distribution of dystrophin expression in 25 pigs with dystrophinopathy. In addition, complementary deoxyribonucleic acid (cDNA) sequencing and western blotting were performed in 6 of the 25 cases, all of which were characterized by degeneration
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A new genotype of hepatitis A virus causing transient liver enzyme elevations in Mauritius-origin laboratory-housed Macaca fascicularis. Vet. Pathol. (IF 2.4) Pub Date : 2023-11-12 Lars Mecklenburg,Rebecca Ducore,Molly Boyle,Andrew Newell,Laura Boone,Joerg Luft,Annette Romeike,Ann-Kathrin Haverkamp,Keith Mansfield,Kelley A Penraat,J J Baczenas,Nick Minor,Shelby L O'Connor,David H O'Connor
Hepatitis A virus (HAV) infects humans and nonhuman primates, typically causing an acute self-limited illness. Three HAV genotypes have been described so far for humans, and three genotypes have been described for nonhuman primates. We observed transiently elevated liver enzymes in Mauritius-origin laboratory-housed macaques in Germany and were not able to demonstrate an etiology including HAV by serology
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Equine sarcoids: A clinicopathologic study of 49 cases, with mitotic count and clinical type predictive of recurrence. Vet. Pathol. (IF 2.4) Pub Date : 2023-11-08 Wilson Karalus,Supatsak Subharat,Geoff Orbell,Bernie Vaatstra,John S Munday
Sarcoids are common mesenchymal neoplasms of horses. Although there are few studies in which sarcoids have been followed over a long period of time, sarcoids are considered locally invasive and have been reported to frequently recur following surgical excision. Currently, no histological features have been identified to predict which sarcoids will recur after excision. The present study comprised 49
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Overview of the Veterinary Cancer Guidelines and Protocols group's "Developing, reporting and validating histologic tumor grading systems". Vet. Pathol. (IF 2.4) Pub Date : 2023-11-03 F Yvonne Schulman,Christof A Bertram,Donald J Meuten,Frances M Moore,Giancarlo Avallone,Alexander Bartel,Pompei Bolfa,Melinda Camus,James K Chambers,Michael J Dark,Nick Dervisis,Melanie J Dobromylskyj,Taryn A Donovan,Robert A Foster,Paula M Krimer,Andrew Miller,Milan Milovancev,Paola Roccabianca,Laura E Selmic,Geoff A Wood
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PDL1 immunohistochemistry in canine neoplasms: Validation of commercial antibodies, standardization of evaluation, and scoring systems. Vet. Pathol. (IF 2.4) Pub Date : 2023-11-03 Luisa Vera Muscatello,Francesca Gobbo,Giancarlo Avallone,Micaela Innao,Cinzia Benazzi,Giulia D'Annunzio,Donatella Romaniello,Massimo Orioles,Mattia Lauriola,Giuseppe Sarli
Immuno-oncology research has brought to light the paradoxical role of immune cells in the induction and elimination of cancer. Programmed cell death protein 1 (PD1), expressed by tumor-infiltrating lymphocytes, and programmed cell death ligand 1 (PDL1), expressed by tumor cells, are immune checkpoint proteins that regulate the antitumor adaptive immune response. This study aimed to validate commercially
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Vulvo-vaginal epithelial tumors in mares: A preliminary investigation on epithelial-mesenchymal transition and tumor-immune microenvironment. Vet. Pathol. (IF 2.4) Pub Date : 2023-11-01 Federico Armando,Ilaria Porcellato,Livia de Paolis,Samanta Mecocci,Benedetta Passeri,Małgorzata Ciurkiewicz,Luca Mechelli,Chiara Grazia De Ciucis,Marzia Pezzolato,Floriana Fruscione,Chiara Brachelente,Vittoria Montemurro,Katia Cappelli,Christina Puff,Wolfgang Baumgärtner,Alessandro Ghelardi,Elisabetta Razzuoli
Vulvo-vaginal epithelial tumors are uncommon in mares, and data on the epithelial-to-mesenchymal transition (EMT) and the tumor-immune microenvironment (TIME) are still lacking. This is a study investigating the equus caballus papillomavirus type 2 (EcPV2) infection state as well as the EMT process and the tumor microenvironment in vulvo-vaginal preneoplastic/ benign (8/22) or malignant (14/22) epithelial
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Pro-inflammatory cytokine expression and the STAT1/3 pathway in canine chronic enteropathy and intestinal T-cell lymphoma. Vet. Pathol. (IF 2.4) Pub Date : 2023-10-31 Kazuhiro Kojima,James K Chambers,Ko Nakashima,Kazuyuki Uchida
The accumulation of intraepithelial lymphocytes (IELs) is a histopathological feature of canine chronic enteropathy (CE), and IELs are considered the cells of origin of intestinal T-cell lymphoma (ITCL). However, the pathogenic mechanism of IEL activation in CE remains unclear. This study hypothesized that the expression of proinflammatory cytokines, associated with cytotoxic T/NK-cell activation,
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Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer. Vet. Pathol. (IF 2.4) Pub Date : 2023-10-31 Travis K Meuten,Gregg A Dean,Douglas H Thamm
Tumors in dogs and humans share many similar molecular and genetic features, incentivizing a better understanding of canine neoplasms not only for the purpose of treating companion animals, but also to facilitate research of spontaneously developing tumors with similar biologic behavior and treatment approaches in an immunologically competent animal model. Multiple tumor types of both species have
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Exudative glomerulonephritis associated with acute leptospirosis in dogs. Vet. Pathol. (IF 2.4) Pub Date : 2023-10-29 Monika Hilbe,Horst Posthaus,Giulia Paternoster,Simone Schuller,Michelle Imlau,Hanne Jahns
In the past 20 years in Switzerland, dogs with suspect acute leptospirosis frequently showed severe glomerular changes that had not been previously reported. These features were characterized by abundant extravasated erythrocytes and fewer neutrophils accompanied by marked fibrin exudation into the urinary space that was interpreted as an exudative glomerulonephritis (GN). This retrospective study
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Lipid storage disease in 4 sibling superb birds-of-paradise (Lophorina superba). Vet. Pathol. (IF 2.4) Pub Date : 2023-10-16 Christina M McKenzie,Matt Marinkovich,Aníbal G Armién,Judy St Leger,Aaron M Armando,Edward A Dennis,Oswald Quehenberger,Alison Righton
Pedigree analysis, clinical, gross, microscopic, ultrastructural, and lipidomic findings in 4 female superb bird-of-paradise (SBOP, Lophorina superba) siblings led to the diagnosis of a primary inherited glycerolipid storage disease. These birds were the offspring of a related breeding pair (inbreeding coefficient = 0.1797) and are the only known SBOPs to display this constellation of lesions. The
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Gastrointestinal tract pathology of the owl monkey (Aotus spp.). Vet. Pathol. (IF 2.4) Pub Date : 2023-10-13 Martha E Hensel,Aline Rodrigues-Hoffmann,Beth K Dray,Gregory K Wilkerson,Wally B Baze,Sarah Sulkosky,Carolyn L Hodo
Owl monkeys are small nocturnal new world primates in the genus Aotus that are most used in biomedical research for malaria. Cardiomyopathy and nephropathy are well-described common diseases contributing to their morbidity and mortality; less is known about lesions affecting the gastrointestinal tract. Records from a 14-year period (2008-2022) at the Keeling Center for Comparative Medicine and Research
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Subcutaneous choriocarcinomas in captive Amargosa voles (Microtus californicus scirpensis). Vet. Pathol. (IF 2.4) Pub Date : 2023-10-13 Sebastian E Carrasco,Amanda L Johnson,Kerriann M Casey,Nora Allan,Mia Reed,Janet E Foley,Denise M Imai
Spontaneous choriocarcinomas are rare, highly vascular, malignant trophoblastic tumors that occur in humans and animals. This report describes the unusual spontaneous presentation of 4 choriocarcinomas within the subcutaneous tissues of 4, multiparous but nongravid, Amargosa voles (Microtus californicus scirpensis) from a captive breeding colony. Two subcutaneous neoplasms were composed of multifocal
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Analysis of cell populations in the normal rhesus macaque (Macaca mulatta) lower intestinal tract and diagnostic thresholds for chronic enterocolitis. Vet. Pathol. (IF 2.4) Pub Date : 2023-10-11 Rebecca L Bacon,Loni Taylor,Stanton B Gray,Carolyn L Hodo
Rhesus macaques (Macaca mulatta) are used extensively in biomedical research, often with a focus on the gastrointestinal tract, and yet a full characterization of their normal resident intestinal cell populations has not been published. In addition, chronic enterocolitis (CE), also known as idiopathic chronic diarrhea, affects up to 25% of colony-housed rhesus macaques, often requiring euthanasia for
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Association of equine gammaherpesvirus-5 with facial lymphohistiocytic interface dermatitis in seven adult horses from the United States. Vet. Pathol. (IF 2.4) Pub Date : 2023-09-09 Jeanine Peters-Kennedy,Christiane V Löhr,Brieuc Cossic,Amy L Glaser,Gerald E Duhamel
Equine herpesvirus-5 (EHV-5) is commonly found in healthy asymptomatic horses worldwide. Although a cause-and-effect relationship has not been thoroughly determined, this virus has been associated with several disease conditions including equine multinodular pulmonary fibrosis (EMPF) and 1 case of interface dermatitis. The authors searched the New York State Animal Health Diagnostic Center database
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Verminous pneumonia in European hedgehogs (Erinaceus europaeus). Vet. Pathol. (IF 2.4) Pub Date : 2023-09-08 Simone Lehmann,Eva Dervas,Andres Ruiz Subira,Ulrike Eulenberger,Angela Gimmel,Felix Grimm,Udo Hetzel,Anja Kipar
The European hedgehog (Erinaceus europaeus) is a common wildlife species in European countries. Populations are declining due to anthropogenic factors and natural diseases. Verminous pneumonia has been observed as a frequent infectious disease in hedgehogs submitted for diagnostic postmortem examination. This prompted the present in-depth investigation on the lungs of 27 necropsied hedgehogs with confirmed
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Amdoparvovirus-associated disease in red pandas (Ailurus fulgens). Vet. Pathol. (IF 2.4) Pub Date : 2023-09-08 Charles E Alex,Pavel Kvapil,Martin D M Busch,Trine Jensen,Kenneth Conley,Kenneth Jackson,Eric L Stubbs,Jenessa Gjeltema,Michael M Garner,Steven V Kubiski,Patricia A Pesavento
The roster of amdoparvoviruses (APVs) in small carnivores is growing rapidly, but in most cases, the consequences of infection are poorly understood. Red panda amdoparvovirus (RPAV) is highly prevalent in zoo-housed red pandas and has been detected in both healthy and sick animals. Clarifying the clinical impact of RPAV in this endangered species is critical, and zoological collections offer a unique
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Canine bufavirus (Carnivore protoparvovirus-3) infection in dogs with respiratory disease. Vet. Pathol. (IF 2.4) Pub Date : 2023-09-08 Chutchai Piewbang,Panida Poonsin,Pattiya Lohavicharn,Tin Van Nguyen,Sitthichok Lacharoje,Tanit Kasantikul,Somporn Techangamsuwan
Canine bufavirus (CBuV) or Carnivore protoparvovirus-3, a nonenveloped DNA virus belonging to the genus Protoparvovirus, family Parvoviridae, has been identified in dogs with respiratory and enteric diseases. Although CBuV detection has been reported in multiple countries, descriptions of pathologic findings associated with infection have not yet been provided. In this study, the authors necropsied
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Special focus issue on invertebrate pathology: A growing discipline requiring veterinary diagnosticians. Vet. Pathol. (IF 2.4) Pub Date : 2023-09-01 Michelle M Dennis,Elise E B LaDouceur
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Cytotoxic dermatitis: Review of the interface dermatitis pattern in veterinary skin diseases. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-31 Verena K Affolter
Interface dermatitis or lichenoid interface dermatitis refers to a cutaneous inflammatory pattern in which keratinocyte cell death is the essential feature. These terms have evolved from the originally described lichenoid tissue reaction. These lesions are the basis for an important group of skin diseases in animals and people where cytotoxic T-cell-mediated epidermal damage is a major pathomechanism
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Outbreak of epizootic hemorrhagic disease in captive reindeer (Rangifer tarandus). Vet. Pathol. (IF 2.4) Pub Date : 2023-08-31 Emma H Torii,Arno Wünschmann,Mia Kim Torchetti,Leo Koster,Albert van Geelen,Randy Atchison,Anne Rivas
In September 2020, an outbreak of epizootic hemorrhagic disease occurred in captive reindeer (Rangifer tarandus) and was associated with neurological signs and mortality. Four reindeer died or were euthanized after acute illness over a 12-day period. Affected reindeer displayed abnormal behavior, neurologic signs, lethargy, and/or lameness. The most consistent gross finding was dark red streaks throughout
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Clinical, histopathological, and molecular characterization of canine pigmented viral plaques. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-29 Margherita Orlandi,Maurizio Mazzei,Francesco Albanese,Luca Pazzini,Martina Mei,Giulia Lazzarini,Mario Forzan,Maria Massaro,Marta Vascellari,Francesca Abramo
Canine pigmented viral plaques (PVPs) are proliferative epidermal lesions caused by canine papillomaviruses (CPVs). Although the lesions are benign, neoplastic transformation has been reported. Cases reported in the literature are few and mainly focused on genome sequencing. The aim of this study was to collect data on the epidemiology, clinicopathological features, and genotyping of PVPs. Fifty-five
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Histological and immunohistochemical features of carcinomas with pulmonary involvement in cattle. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-28 Andréia Vielmo,Igor Ribeiro Santos,Manoela Marchezan Piva,Marcele Bettim Bandinelli,Saulo Petinatti Pavarini,Welden Panziera,David Driemeier
Primary pulmonary neoplasms in cattle are rare. There are few studies on the pathological findings of these neoplasms in this species. This study aimed to describe the histological and immunohistochemical findings of primary and metastatic pulmonary carcinomas in cattle. We conducted a retrospective study of 19 cases of epithelial neoplasms with pulmonary involvement. Histologically, most of the neoplasms
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Primary and secondary leptomeningeal gliomatosis in dogs. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-14 Daniel R Rissi,Vicente A A Reyes,Taryn A Donovan,Molly E Church,Elizabeth W Howerth,Andrea Klang,Kevin D Woolard,Andrew D Miller
Leptomeningeal gliomatosis (LG) is characterized by extensive dissemination of neoplastic glial cells in the subarachnoid space either without an intraparenchymal glioma (primary LG or PLG) or secondary to an intraparenchymal glioma (secondary LG or SLG). Given the low frequency of LG in human and veterinary medicine, specific diagnostic criteria are lacking. Here, we describe 14 cases of canine LG
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Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-10 Megan E Schreeg,John M Cullen,James Robertson,Jody L Gookin
Conjoining of the major pancreatic duct and common bile duct at the major duodenal papilla (MDP) is suspected to predispose cats to the clinical syndrome of "triaditis." However, microanatomy of the MDP or presence of lesions at the MDP has not been assessed in cats with or without triaditis. The aims of this study were to characterize feline MDP histomorphology and to identify associations between
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Nodular hyperplasia of lymphoglandular complexes in dogs: A potential diagnostic pitfall for rectal masses. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-07 Andrew W Stent,Matti Kiupel,Julien R S Dandrieux,Rebekah Liffman,Monali M Bera
Lymphoglandular complexes are components of the gut-associated lymphoid tissue that are characterized by submucosal lymphoid aggregates invested by projections of mucosal epithelium. Reports of pathology involving these structures are rare in both human and veterinary literature. Here, the authors report 2 cases of rectal masses excised from dogs following a period of tenesmus and hematochezia. In
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Systemic avian poxvirus infections associated with the B1 subclade of canarypox virus. Vet. Pathol. (IF 2.4) Pub Date : 2023-08-07 Devinn M Sinnott,Jennifer Burchell,Carmel Witte,Rachel Burns,Steven Kubiski
Avian poxvirus infections typically manifest as 2 forms: cutaneous ("dry") pox, characterized by proliferative nodules on the skin, and diphtheritic ("wet") pox, characterized by plaques of caseous exudate in the oropharynx and upper respiratory and gastrointestinal tracts. Systemic spread of virus to visceral organs beyond the skin and mucous membranes is rarely reported. Out of 151 cases diagnosed
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Detection of skunk adenovirus-1 in domestic ferrets (Mustela putorius). Vet. Pathol. (IF 2.4) Pub Date : 2023-08-06 Maria E Orbay-Cerrato,Roger Alan Nilsen,Nicole Gottdenker,Rita McManamon,Jessica A Elbert,Justin M Stilwell,Mary B Ard,Branson W Ritchie,Brittany McHale
We describe gross pathology, histopathology, ultrastructure, and molecular characterization of skunk adenovirus 1 (SkAdV-1) in 3 ferrets (Mustela putorius) submitted to the Infectious Diseases Laboratory, Zoo and Exotic Animal Pathology Service at the University of Georgia. Case 1 came from a cohort with a 6-week history of multiple ferrets with respiratory disease and mortality. Cases 2 and 3 were
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An introduction to lesions and histology of scleractinian corals. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-31 Aine Hawthorn,Ilze K Berzins,Michelle M Dennis,Matti Kiupel,Alisa L Newton,Esther C Peters,Vicente A Reyes,Thierry M Work
Stony corals (Scleractinia) are in the Phylum Cnidaria (cnidae referring to various types of stinging cells). They may be solitary or colonial, but all secrete an external, supporting aragonite skeleton. Large, colonial members of this phylum are responsible for the accretion of coral reefs in tropical and subtropical waters that form the foundations of the most biodiverse marine ecosystems. Coral
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Pattern analysis for the diagnosis of inflammatory skin lesions in domestic animals: An overview. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-29 Verena K Affolter,Julie A Yager,Claudia von Tscharner,Elizabeth Mauldin
Pattern analysis of inflammatory skin diseases is a technique that offers a systematic approach to the histologic diagnosis of skin diseases. First introduced to human dermatopathology in the 1970s, it was widely adopted by veterinary pathologists for the histologic diagnosis of skin diseases in animals. As the inflammatory pattern reflects, to varying extents, aspects of the underlying disease pathogenesis
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Granulomatous mural folliculitis in 16 domestic goats: Infection with malignant catarrhal fever viruses and colocalization with ovine herpesvirus-2 using in situ hybridization. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-29 Thomas Westermann,Elena Alina Demeter,Diego G Diel,Randall W Renshaw,Melissa A Laverack,Rhea S Gerdes,Jeanine Peters-Kennedy
Granulomatous mural folliculitis (GMF) is an uncommon reaction pattern occasionally observed in nonadapted ruminant hosts infected with malignant catarrhal fever viruses. This report characterizes GMF and concurrent cutaneous lesions in 16 goats with crusting dermatitis using histochemistry including hematoxylin and eosin, periodic acid-Schiff, and Grocott's methenamine silver, and immunohistochemistry
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Establishment and characterization of a novel cell line and xenotransplant mouse model derived from feline colorectal adenocarcinoma. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-29 Mizuho Uneyama,James K Chambers,Tadashi Fujii,Ko Nakashima,Kazuyuki Uchida
Colorectal adenocarcinoma is an aggressive malignant tumor in cats that frequently metastasizes to the lymph nodes and/or distant organs. However, research on feline colorectal adenocarcinoma is limited, and experimental models have not been established. A novel cell line, FeLeco-G7, was established from the lymph node of a 12-year-old spayed female Maine Coon cat with metastatic colorectal adenocarcinoma
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A review of cutaneous hypersensitivity reactions in dogs: A diagnostician's guide to allergy. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-29 Charles W Bradley,Elizabeth A Mauldin,Daniel O Morris
Allergic dermatoses are common in people and domestic animals. Resultant lesions are routinely biopsied and submitted for histological examination to confirm a diagnosis or rule out diseases with overlapping or atypical clinical features. Diagnostic pathologists and clinicians are often faced with the difficult task of determining whether an allergic reaction pattern is present on both the microscopic
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Feline sporotrichosis: Characterization of cutaneous and extracutaneous lesions using different diagnostic methods. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-29 Agna F Santos,Maria I Azevedo,Camila I Amaral,Nikollye A Grom,Fabricio Marinho,Camila S F de Oliveira,Danielle F de M Soares,Maria H F Morais,Silvana T Brandão,Rodrigo C Menezes,Roselene Ecco
Sporotrichosis is a mycotic infection of the cutaneous and subcutaneous tissues caused by Sporothrix spp. that can also cause extracutaneous manifestations. This study aimed to characterize cutaneous and extracutaneous sporotrichosis lesions in cats. Over 1 year, 102 cats rescued by the Zoonoses Control Center of Belo Horizonte, Brazil, euthanized with clinical suspicion of feline sporotrichosis were
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Automated diagnosis of 7 canine skin tumors using machine learning on H&E-stained whole slide images. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-29 Marco Fragoso-Garcia,Frauke Wilm,Christof A Bertram,Sophie Merz,Anja Schmidt,Taryn Donovan,Andrea Fuchs-Baumgartinger,Alexander Bartel,Christian Marzahl,Laura Diehl,Chloe Puget,Andreas Maier,Marc Aubreville,Katharina Breininger,Robert Klopfleisch
Microscopic evaluation of hematoxylin and eosin-stained slides is still the diagnostic gold standard for a variety of diseases, including neoplasms. Nevertheless, intra- and interrater variability are well documented among pathologists. So far, computer assistance via automated image analysis has shown potential to support pathologists in improving accuracy and reproducibility of quantitative tasks
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Auricular and laryngeal chondritis in nursery and finishing pigs. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-20 Anderson H Gris,Manoela M Piva,Claiton I Schwertz,Ana P Mori,Camila Saremba,Daniel M Simon,Luciana Sonne,Saulo P Pavarini,David Driemeier
This work aimed to characterize the clinic-pathological presentation of an outbreak of auricular and laryngeal chondritis in pigs. Visits were made to pig farms, where the clinical history was obtained, and clinical and postmortem examinations were performed. In those farms, 3% to 4% of pigs presented otohematomas, which started in the nursery and extended to the finishing phase. Moreover, some finishing
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A retrospective study of pathologic findings in cephalopods (extant subclasses: Coleoidea and Nautiloidea) under laboratory and aquarium management. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-18 Andrew F Rich,Daniela Denk,Cheryl R Sangster,Mark F Stidworthy
This retrospective study examines pathologic findings in 593 captive cephalopods (340 octopuses, 130 cuttlefish, 33 squid, and 90 nautiluses; 22 species in total) submitted to International Zoo Veterinary Group Pathology between May 2003 and August 2022. Common octopus, European common cuttlefish, hummingbird bobtail squid, and chambered nautilus were the most numerous species from the included orders
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Multipathogen infections and multifactorial pathogenesis involved in noble pen shell (Pinna nobilis) mass mortality events: Background and current pathologic approaches. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-17 Francesca Carella,Dušan Palić,Tomislav Šarić,Ivan Župan,Bartolomeo Gorgoglione,Patricia Prado,Karl B Andree,Ioannis A Giantsis,Basile Michaelidis,Athanasios Lattos,John A Theodorou,Juan Luis Barja Perez,Sergio Rodriguez,Fabio Scarpa,Marco Casu,Elisabetta Antuofermo,Daria Sanna,Domenico Otranto,Rossella Panarese,Carmelo Iaria,Fabio Marino,Gionata De Vico
Disease outbreaks in several ecologically or commercially important invertebrate marine species have been reported in recent years all over the world. Mass mortality events (MMEs) have affected the noble pen shell (Pinna nobilis), causing its near extinction. Our knowledge of the dynamics of diseases affecting this species is still unclear. Early studies investigating the causative etiological agent
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California sea lion (Zalophus californianus) lymph-node explant reveals involvement and possible transcriptional regulation of SLAM and nectin-4 during phocine distemper virus infection. Vet. Pathol. (IF 2.4) Pub Date : 2023-07-17 Omar Gonzales-Viera,Tracey Goldstein,Pádraig Duignan,Piyaporn Eiamcharoen,M Kevin Keel
Phocine distemper virus (PDV) is a significant cause of mortality for phocid seals; however, the susceptibility of otariids to this virus is poorly understood. The authors used a lymph-node explant culture system from California sea lions (Zalophus californianus, CSL) to investigate: (1) the role of signaling lymphocyte activation molecule (SLAM) and nectin-4 in PDV infection and their cellular expression