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Oral mucosal changes caused by nicotine pouches: case series Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-19 Sintija Miluna-Meldere, Sarlote Agate Vanka, Ingus Skadins, Juta Kroica, Maris Sperga, Dagnija Rostoka
Oral nicotine pouches are the latest products in the tobacco industry. They are manufactured by large tobacco companies and entice tobacco or nicotine addicts, although the products are presented as a ‘harmless choice.’ Nevertheless, dentists and oral health specialists worry about oral mucosal changes due to product interactions with the oral mucosa. Unfortunately, there are no case reports of oral
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Pseudoinvasion and squamous metaplasia/morules in colorectal adenomatous polyp: a case report and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-17 Li Shi, Huamin Li, Shulian Li, Songyan Lin, Ying Wu
Submucosal pseudoinvasion and squamous metaplasia (SM) are incidental and special morphological findings in colorectal adenomas, and both can mimic invasive carcinoma. The coexistence of these two findings further increases the risk of misdiagnosis, posing a great diagnostic challenge to pathologists. From 1979 to 2022, only 8 cases have been reported, which was extremely rare. In this report, we presented
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Model for detecting metastatic deposits in lymph nodes of colorectal carcinoma on digital/ non-WSI images Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-16 Talat Zehra, Sarosh Moeen, Mahin Shams, Muhammad Raza, Amna Khurshid, Asad Jafri, Jamshid Abdul-Ghafar
Colorectal cancer (CRC) constitutes around 10% of global cancer diagnoses and death due to cancer. Treatment involves the surgical resection of the tumor and regional lymph nodes. Assessment of multiple lymph node demands meticulous examination by skilled pathologists, which can be arduous, prompting consideration for an artificial intelligence (AI)-supported workflow due to the growing number of slides
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Clinicopathological characteristics and genetic features of young and senior Ewing sarcoma patients Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-16 Jiali Li, Yuan Ji
Ewing sarcoma (EwS) is a highly malignant and heterogeneous tumor. Exploring clinicopathological characteristics and genetic features of EwS is critical for prognosis and treatment regimen. Clinicopathological characteristics and genetic features of young (≤ 30y) and senior (> 30y) EwS patients were analyzed based on histology, phenotype, and next-generation sequencing (NGS) detection. The young group
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Navigating the diagnostic gray zone: a challenging case of pancreatic high-grade neuroendocrine neoplasm Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-12 Brooke Mullen, Albert L. Sy, Priscila Dias Goncalves, M. Lisa Zhang
Grade 3 neuroendocrine tumor (G3 PanNET) and poorly differentiated neuroendocrine carcinoma (PanNEC) of the pancreas are considered distinct entities from a biological and prognostic perspective but may have overlapping features complicating a definitive diagnosis. A 52-year-old female presented with a pancreatic body mass and liver lesions. Initial biopsies showed variable lower- and higher-grade
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Post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation: a case report, meta-analysis, and systematic review Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-07 You-yuan Su, Ya-fei Yu, Zhen-yu Yan, Ya-jing Zhao, Jian-wei Lou, Feng Xue, Miao Xu, Qi Feng, Xue-bin Ji, Xiao-yuan Dong, Wen Wang, Chuan-fang Liu, Jun Peng, Xin-guang Liu
Post-transplant lymphoproliferative disorders (PTLD) are rare but severe complications that occur after solid organ or allogeneic hematopoietic stem cell transplantations (allo-HSCT), with rapid progression and high mortality. Primary central nervous system (CNS)-PTLD are rarely recognized histo-pathologically. In addition, the diagnostic value of the Epstein–Barr virus (EBV) DNA copies in CNS-PTLD
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TRPS1, a sensitive marker for different histological and molecular types of breast cancer Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-06 Change Kong, Baohua Yu, Rui Bi, Xiaoli Xu, Yufan Cheng, Wentao Yang, Ruohong Shui
We explored Trichorhinophalangeal syndrome type 1 (TRPS1) expression in special types of breast carcinoma, and analyzed the correlation between TRPS1 and androgen receptor (AR) expression in triple-negative breast cancer (TNBC). TRPS1 expression was analyzed in 801 patients with special types of breast carcinoma. A total of 969 TNBC were used to analyze the correlation between the expression of TRPS1
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Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-05 Luojia Yang, Qin Wei, Xinran Chen, Yang Yang, Qingbo Huang, Baojun Wang, Xin Ma
Clear cell renal cell carcinoma (ccRCC) remains one of the most lethal urological malignancies even though a great number of improvements in diagnosis and management have achieved over the past few decades. Accumulated evidence revealed that histone deacetylases (HDACs) play vital role in cell proliferation, differentiation and apoptosis. Nevertheless, the biological functions of histone deacetylation
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Correction: Utilizing deep learning model for assessing melanocytic density in resection margins of lentigo maligna Diagn. Pathol. (IF 2.4) Pub Date : 2024-09-05 Jan Siarov, Darshan Kumar, John Paoli, Johan Mölne, Martin Gillstedt, Noora Neittaanmäki
Correction: Diagnostic Pathology 19, 106 (2024) https://doi.org/10.1186/s13000-024-01532-y Following publication of the original article [1], the authors noticed that one author name is in incorrect order. It should be Noora Neittaanmäki (Neittaanmäki as surname) instead of Neittaanmäki Noora. The original article [1] has been updated. Siarov J, Kumar D, Paoli J, et al. Utilizing deep learning model
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The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-30 Adam Šafanda, Michaela Kendall Bártů, Romana Michálková, Marián Švajdler, Tetiana Shatokhina, Jan Laco, Radoslav Matěj, Gábor Méhes, Jana Drozenová, Jitka Hausnerová, Zuzana Špůrková, Jozef Škarda, Mária Hácová, Monika Náležinská, Pavel Dundr, Kristýna Němejcová
Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, evaluating its potential utility in differential diagnosis, prognosis, and therapeutic application. We
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Correction: Integrating bioinformatics and machine learning methods to analyze diagnostic biomarkers for HBV-induced hepatocellular carcinoma Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-29 Anyin Yang, Jianping Liu, Mengru Li, Hong Zhang, Xulei Zhang, Lianping Wu
Correction: Diagnostic Pathology 19, 105 (2024) https://doi.org/10.1186/s13000-024-01528-8 Following publication of the original article [1], the given and family names of all authors were incorrectly structured. The incorrect names are: Yang Anyin, Liu Jianping, Li Mengru, Zhang Hong, Zhang Xulei, Wu Lianping. The correct names should be: Anyin Yang, Jianping Liu, Mengru Li, Hong Zhang, Xulei Zhang
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Exploring LGR5 as a prognostic marker of extrahepatic cholangiocarcinoma: insights from expression analysis and clinical correlations Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-28 Hisashi Tamada, Takeshi Uehara, Takahiro Yoshizawa, Mai Iwaya, Shiho Asaka, Tomoyuki Nakajima, Masato Kamakura, Hiroyoshi Ota
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a cancer stem cell (CSC) marker of colorectal cancer and may be a CSC marker of other cancer types. Few studies have been conducted on LGR5 expression in extrahepatic cholangiocarcinoma (ECC). We analyzed LGR5 expression using RNAscope, a highly sensitive RNA in situ hybridization technique. Fifty-three ECCs were selected from the
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Podoplanin immunoexpression in odontogenic lesions: a systematic review, meta-analysis, and integrated bioinformatic analysis Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-24 Mario Alberto Alarcón-Sánchez, Getsemani Luna-Bonilla, Selenne Romero-Servin, Artak Heboyan
Podoplanin (PDPN) is a transmembrane glycoprotein implicated in the pathogenesis of odontogenic lesions (OL). It is localized at the membrane and cytoplasmic level, and its interaction with other proteins could trigger cell proliferation, invasion and migration. The main objective of this systematic review is to explore the immunoexpression pattern of podoplanin in OL. In addition, as secondary objectives
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Warthin tumor concomitant with mantle cell lymphoma: a case report and review of literature Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-24 Hai-Chao Tong, Shuang Ma, Lan Chen, Xiangyun Meng, Ying-Chun Li, Le-Yao Li, Lingyun Dong, Wan-Lin Zhang, Tyler Wildes, Lian-He Yang, Endi Wang
Warthin tumor (WT) is the second most common benign tumor in salivary gland. It has a slow growth rate and most frequently occurs in the parotid gland. Most patients present with an incidental finding of a painless mass inferior/anterior to the ear. Besides the epithelial component of the tumor, WT is characteristically associated with lymphoid stroma that is considered benign. While there have been
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Expression and clinical significance of CLDN7 and its immune-related cells in breast cancer Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-22 Xiaojie Fan, Aifeng Qi, Meng Zhang, Ying Jia, Shi Li, Dandan Han, Yueping Liu
CLDN is a core component of tight junctions (TJs). Abnormal expressions of CLDNs are commonly detected in various types of tumors. CLDNs are of interest as a potential therapeutic target. CLDNs are closely associated with most cancers of epithelial origin, especially when CLDN7 promotes cancer cell metastasis, such as in gastric, cervical, and ovarian cancers.Its expression and prognosis in breast
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Prognostic and immune infiltration implications of SIGLEC9 in SKCM Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-17 Peipei Yang, Yunhui Jiang, Rong Chen, Junhan Yang, Mengting Liu, Xieping Huang, Ganglin Xu, Rui Hao
The occurrence and progression of skin cutaneous melanoma (SKCM) is strongly associated with immune cells infiltrating the tumor microenvironment (TME). This study examined the expression, prognosis, and immune relevance of SIGLEC9 in SKCM using multiple online databases. Analysis of the GEPIA2 and Ualcan databases revealed that SIGLEC9 is highly expressed in SKCM, and patients with high SIGLEC9 expression
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Clinicopathological diagnosis of Lennert lymphoma: a case report and review of the literature Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-16 Shun Ding, Jiao Chen, Jiajun Su, Jiewen Liu, Weihua Yin, Fengjie Qi
Lennert lymphoma (LL) is a variant of peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), also known as a lymphoepithelioid variant of PTCL. Because of the rarity and lack of clear-cut diagnostic criteria, LL is susceptible tomisdiagnosis. Although previously diagnosed with LL might be reclassified and evaluated with the advent of of molecular and/or genetic findings, cytomorphology and
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Clinicopathological and genetic characterization of radiotherapy-induced undifferentiated pleomorphic sarcoma following breast cancer: a case series of three tumors and comprehensive literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-15 Ting Lei, Zhiyi Shen, Mengjia Shen, Lingfang Du, Yongqiang Shi, Yan Peng, Zidi Zhou, Wenyue Da, Xi Chen, Qing Li
Compared to primary breast sarcoma (BSs), radiotherapy-induced sarcoma (RIS) is a less frequent type of secondary breast sarcoma. Undifferentiated pleomorphic sarcoma (UPS) is an even rarer occurrence within the RIS category. This study aimed to present the clinicopathologic and molecular features of breast radiotherapy-induced UPS. A retrospective study was conducted at the Third Affiliated Hospital
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Loss of clear cell characteristics in aggressive clear cell odontogenic carcinoma: a case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-13 Yanan Sun, Bo Li, Yaying Hu, Fu Chen, Junchen Pan, Yi Zhou, Jiali Zhang
Clear cell odontogenic carcinoma (CCOC) is an odontogenic carcinoma characterized by sheets and islands of vacuolated and clear cells. The diagnosis of atypical CCOC can pose a challenge when tumor cells deviate from their characteristic clear morphology, even with the aid of genetic profiling for CCOC identification. In this manuscript, we detailed the inaugural instance of a recurrently recurring
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Spindle epithelial tumor with thymus-like elements (SETTLE): a diagnostic challenge with distinct therapeutic implication; case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-13 Prerna Chadha, Meenakshi Kamboj, Sunil Pasricha, Vikas Arora, Vishal Yadav, Manoj Gupta, Anurag Mehta
Spindle epithelial tumor with thymus-like elements (SETTLE) is a rare malignant neoplasm of the thyroid gland which is believed to arise from intrathyroidal thymic tissue. It predominantly affects young adults and children presenting with a thyroid mass of variable duration and rarely occurs in adults. It has a high overall survival with a tendency for delayed metastasis. SETTLE is a biphasic lobulated
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Compound heterozygous CFTR variants (Q1352H and 5T; TG13) in a Chinese patient with cystic fibrosis Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-06 Run Guo, Yingxue Zou, Yongsheng Guo, Weiwei Gao
Cystic fibrosis (CF) is an autosomal recessive inherited disease caused by variants of cystic fibrosis transmembrane conductance regulation (CFTR) gene. This report presents a case of a Chinese boy diagnosed with CF, attributed to the presence of two specific CFTR gene variations: 4056G > C (NM_000492.4) (p.Gln1352His, legacy: Q1352H) and c.1210-34TG[13]T[5] (NM_000492.4)(legacy: 5T; TG13). A ten-year-old
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Utilizing deep learning model for assessing melanocytic density in resection margins of lentigo maligna Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-03 Jan Siarov, Darshan Kumar, John Paoli, Johan Mölne, Martin Gillstedt, Neittaanmäki Noora
Surgical excision with clear histopathological margins is the preferred treatment to prevent progression of lentigo maligna (LM) to invasive melanoma. However, the assessment of resection margins on sun-damaged skin is challenging. We developed a deep learning model for detection of melanocytes in resection margins of LM. In total, 353 whole slide images (WSIs) were included. 295 WSIs were used for
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Integrating bioinformatics and machine learning methods to analyze diagnostic biomarkers for HBV-induced hepatocellular carcinoma Diagn. Pathol. (IF 2.4) Pub Date : 2024-08-02 Yang Anyin, Liu Jianping, Li Mengru, Zhang Hong, Zhang Xulei, Wu Lianping
Hepatocellular carcinoma (HCC) is a malignant tumor. It is estimated that approximately 50–80% of HCC cases worldwide are caused by hepatitis b virus (HBV) infection, and other pathogenic factors have been shown to promote the development of HCC when coexisting with HBV. Understanding the molecular mechanisms of HBV-induced hepatocellular carcinoma (HBV-HCC) is crucial for the prevention, diagnosis
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Tonsillar synovial sarcoma, unusual anatomical location: case report and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-26 Sohaib M. Al-Khatib, Maram M. AlSheyab, Sura B. AlOmari
Synovial sarcoma is a rare soft tissue malignancy, occasionally found in the head and neck region. The diagnosis necessitates a multidisciplinary approach involving the clinical presentation, proper imaging studies and histological confirmation, with molecular testing for definitive identification. Treatment entails surgical resection with adjuvant therapies as needed. A 33-year-old male patient presented
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Extracranial metastatic oligodendroglioma with molecular progression, case presentation Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-26 Nour Kurdi, Attila Mokánszki, Ingrid Balogh, Anikó Ujfalusi, Sándor Szabó, Gábor Méhes, Judit Bedekovics
Extraneural metastasis of central nervous system tumors is generally rare and most often reported in glioblastomas and medulloblastomas, whereas oligodendrogliomas seem to have the lowest risk of extracranial metastasis. Given its infrequent occurrence, both the diagnosis and therapy of metastatic oligodendroglioma is often challenging. This case study presents an oligodendroglioma, the isocitrate
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Revealing the clinical impact of MTOR and ARID2 gene mutations on MALT lymphoma of the alimentary canal using targeted sequencing Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-25 Xiang Huang, Jiafei Zeng, Yuqing Luo, Shuai Luo, Yao Li, Jinjing Wang
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are a group of diseases with marked heterogeneity, including clinical, immunohistochemical, and molecular heterogeneity. The disease remains unspecified in the genetic landscape with only a few sequencing studies to date; however, systematic studies of alimentary canal MALT lymphoma have not been reported. To better
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EBV-positive small cell neuroendocrine carcinoma of nasopharynx as a probably unique subtype of neuroendocrine carcinoma: a clinicopathologic study of three cases and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-24 Ying Chen, Ning Zhou, Caijun Huang, Xin He, Xiaodong Wang, Hao Tang, Wenyan Wang, Jiashuang Wang, Tao Li, Deyu Guo
There is currently scarcity of information on small cell neuroendocrine carcinoma of the nasopharynx (SCNEC-nasopharynx). It is believed that this type of cancer is not associated with Epstein-Barr virus (EBV) infection and is indistinguishable from classic SCNEC occurring in other organs. Herein we provided 3 cases of nasopharyngeal mass in our hospital, two males and one female. On admission, these
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Elucidating the nature of acinic cell carcinoma of the breast with high-grade morphology: evidence from case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-24 Yunjie Ge, Xianping Wei, Jing-Nan Liu, Ping-Li Sun, Hongwen Gao
Acinic cell carcinoma (AciCC) of the breast is a rare subtype of breast cancer. It was considered a low-grade triple-negative breast cancer (TNBC) with the potential to progress or transform into a high-grade lesion because of the molecular similarities with conventional aggressive TNBC in several genetic studies. Microscopically, the coexistence of classical low-grade and high-grade triple-negative
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Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-18 Xiumei Hu, Xiangyang Dai, Xinmeng Guo, Xingran Jiang, Yunlong Li, Hongying Zhao, Jun Lu, Xue Li, Mulan Jin
Bone marrow fibrosis (BMF) severely impacts both the quality of life and the efficacy of diagnostic procedures. However, the correlation between BMF and clinicopathological features, cytogenetic changes, and prognosis of newly diagnosed multiple myeloma (NDMM) remains unclear. This study determined the incidence, patient characteristics, and clinical outcomes of patients with NDMM with BMF. The clinical
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A rare adult case of primary uterine rhabdomyosarcoma with mixed pattern: a clinicopathological & immunohistochemical study with literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-17 Nehal K.H. Kamel, Eiman Adel Hasby
Rhabdomyosarcomas are aggressive tumors that comprise a group of morphologically similar but biologically diverse lesions. Owing to its rarity, Mixed pattern RMS (ARMS and ERMS) constitutes a diagnostic and therapeutic dilemma. Herein is presented a very rare case of mixed alveolar & embryonal rhabdomyosarcoma in the uterus of a 68-year-old woman. The wall of the uterine corpus & cervix was replaced
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Immunohistochemistry staining of Eag1 and p16/Ki-67 can help improve the management of patients with cervical intraepithelial Neoplasia after cold knife conversion Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-11 Shikang Qiu, Qiannan Wang, Huihui Jiang, Limin Feng
Immunohistochemistry (IHC) is widely used in the management of patients with cervical intraepithelial neoplasia (CIN) but still has many limitations in clinical practice. We analyzed the correlation of new biomarkers with the severity of CIN and follow-up outcomes in patients after conization to improve the management of patients with CIN. IHC staining of Eag1 and p16/Ki-67 was performed on cervical
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Difficulty in diagnosing intracranial infection caused by Mycobacterium avium in an AIDS patient: case report and review of the literature Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-09 Mengyan Wang, Yahui Cui, Jinchuan Shi, Jun Yan
Mycobacterium avium complex (MAC) is an uncommon clinical pathogen, especially in the central nervous system (CNS), and carries a poor prognosis. MAC infections commonly present as immune reconstitution disease (IRD) in HIV patients. Herein, we report a case of intracranial infection caused by MAC in an AIDS patient without disseminated MAC (DMAC) and immune reconstitution inflammatory syndrome (IRIS)
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Microsecretory adenocarcinoma of the hard palate: a case report and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-09 Yin Lu, Yanlin Wen, Sha Feng, Wenting Huang
Microsecretory adenocarcinoma (MSA) is a new type of salivary gland neoplasm identified in the 2022 World Health Organization Classification of Head and Neck Tumour (Skalova et al., Head Neck Pathol 16:40-53, 2022) and is characterized by a unique set of histomorphologic and immunohistochemical features and a recurrent MEF2C::SS18 fusion. MSA was initially misdiagnosed as another salivary gland tumour
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Clinicopathological characteristics and prognosis of uterine sarcoma: a 10-year retrospective single-center study in China Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-05 Jin-feng Wang, Chen Li, Jing-yi Yang, Yue-ling Wang, Jing Ji
Uterine sarcoma is a rare and heterogeneous gynecological malignancy characterized by aggressive progression and poor prognosis. The current study aimed to investigate the relationship between clinicopathological characteristics and the prognosis of uterine sarcoma in Chinese patients. In this single-center retrospective study, we reviewed the medical records of 75 patients with histologically verified
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Molecular alterations and prognosis of breast cancer with cutaneous metastasis Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-05 Yan Xu, Li Ding, Chao Li, Bin Hua, Sha Wang, Junli Zhang, Cuicui Liu, Rongyun Guo, YongQiang Zhang
Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment and poor prognosis. A better understanding of the molecular alterations involved in metastasis is essential, which would help identify diagnostic and efficacy biomarkers for CM. : We retrospectively reviewed a total of 13 patients with histological or cytological diagnosis
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Establishment of a promising vitiligo mouse model for pathogenesis and treatment studies Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-03 Ruirui Fan, Jie Gao
Vitiligo is a chronic dermatological condition characterized by the progressive loss of melanocytes, for which traditional therapy has shown limited efficacy. This study aimed to establish a vitiligo model with easy operability, high repeatability, and stable depigmentation to provide a foundation for studying the pathogenesis and developing novel therapies for vitiligo. (1) Establishing vitiligo model:
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Primary lung chordoma: a case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-03 Naoko Shigeta, Tetsuya Isaka, Kyoko Ono, Mio Tanaka, Tomoyuki Yokose, Hiroyuki Adachi, Wataru Usuba, Hiroyuki Ito
Chordoma, a rare malignant tumor arising from notochordal tissue, usually occurs along the spinal axis. Only a few published reports of primary lung chordomas exist. Herein, we present a case of primary lung chordoma and discuss important considerations for diagnosing rare chordomas. We report a case of primary lung chordoma in a 39-year-old male with a history of testicular mixed germ-cell tumor of
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Comparison of clinicopathological features between cerebral cystic and alveolar echinococcosis: analysis of 27 cerebral echinococcosis cases in Xinjiang, China Diagn. Pathol. (IF 2.4) Pub Date : 2024-07-01 Wenmei Ma, Zhiping Ma, Yi Shi, Xuelian Pang, Maiweilidan Yimingjiang, Zhe Dang, Wenli Cui, Renyong Lin, Wei Zhang
Cerebral echinococcosis is relatively rare, and it is important to distinguish cerebral cystic echinococcosis (CCE) from cerebral alveolar echinococcosis (CAE) in terms of pathological diagnosis. We aim to describe the different clinicopathological features among patients with CCE and CAE. We collected 27 cases of cerebral echinococcosis which were diagnosed in the Department of Pathology of the First
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Sudden unexpected death after initial infusion of rituximab for Waldenström macroglobulinemia/lymphoplasmacytic lymphoma: an autopsy case Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-28 Shojiro Ichimata, Yukiko Hata, Kazuhiro Nomoto, Tsutomu Sato, Naoki Nishida
Waldenström’s macroglobulinemia (WM) is defined as a lymphoplasmacytic lymphoma (LPL) involving the bone marrow (BM) with presence of IgM monoclonal protein, and comprises > 95% of all LPL cases. Rituximab-based regimens have been predominant in the management of WM. Infusion-related reactions (IRRs) are a primary concern with rituximab, although it is generally better tolerated with less toxicity
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Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-22 Flavia D’Angelo, Franck Monnien, Alexis Overs, Irvin Pem, Fanny Dor, Marine Abad, Sophie Felix, Zohair Selmani, Zaher Lakkis, Christophe Borg, Alexandre Doussot, Fréderic Bibeau, Chloé Molimard
HER2-targeted therapies have recently emerged as an option in the management of metastatic colorectal cancer (mCRC) overexpressing HER2. However, data regarding HER2 status in primary CRC and its corresponding liver metastases are limited, potentially influencing clinical decisions. Therefore, the aim of this study was to compare the HER2 status in primary CRC and paired liver metastases. Patients
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A rare case of asymptomatic giant pulmonary hamartoma Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-22 Xiaoming Fan, Barry Breaux, Laura Leonards, Rusella Mirza
Pulmonary hamartomas are benign lung lesions. Histopathologically, pulmonary hamartoma is composed of varying amounts of mesenchymal elements, including chondroid tissue, mature adipose tissue, fibrous stroma, smooth muscle, and entrapped respiratory epithelium. Most pulmonary hamartoma cases are asymptomatic and found incidentally during imaging. They usually appear as well-circumscribed lesions with
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Transformation of t(14;18)-negative follicular lymphoma to plasmablastic lymphoma: a case report with analysis of genetic evolution Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-22 Sojung Lim, Jiwon Koh, Jeong Mo Bae, Hongseok Yun, Cheol Lee, Jin Ho Paik, Tae Min Kim, Yoon Kyung Jeon
Follicular lymphoma (FL) is characterized by t(14;18)(q32;q21) involving the IGH and BCL2 genes. However, 10–15% of FLs lack the BCL2 rearrangement. These BCL2-rearrangement−negative FLs are clinically, pathologically, and genetically heterogeneous. The biological behavior and histological transformation of such FLs are not adequately characterized. Here, we report the first case of t(14;18)-negative
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Emerging human pulmonary dirofilariasis in Hungary: a single center experience Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-21 Levente Kuthi, Tamás Zombori, László Tiszlavicz, Fanni Hegedűs, Szintia Almási, Bence Baráth, Mohammed Almakrami, Mohammad Jamal EJ, Nikolett Barta, Zsuzsanna Ujfaludi, Tibor Pankotai, Adrienn Hajdu, József Furák, Anita Sejben
Human pulmonary dirofilariasis (HPD) is rare in Hungary, and it stems from Dirofilaria immitis, mainly transmitted through mosquito bites, with dogs as primary hosts. Despite its prevalence in veterinary settings, human cases are infrequent. Historically, Mediterranean countries report most HPD cases, but sporadic cases occur in temperate European regions. Radiologically, HPD often manifests in a non-specific
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Evaluation of OVOL1 and Filaggrin immunohistochemical expression and clinical relevance in psoriasis Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-21 Aiat Shaban Hemida, Mostafa Ahmed Hammam, Aya Ahmed Swilam, Wafaa Ahmed Shehata
Psoriasis is a disease of overactive immune system. OVOL1 and Filaggrin have been associated with many inflammatory skin lesions. To the best of our knowledge, the correlation between OVOL1 and Filaggrin in psoriasis was not previously investigated. This work aims to search the immunohistochemical expression and correlation between OVOL1 and Filaggrin in psoriasis. Slides cut from paraffin blocks of
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Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-21 Dilara Akhoundova, Stefanie Fischer, Joanna Triscott, Marika Lehner, Phillip Thienger, Sina Maletti, Muriel Jacquet, Dinda S.H. Lubis, Lukas Bubendorf, Wolfram Jochum, Mark A. Rubin
Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin signaling pathway, implicated in PCa progression and treatment resistance. To date, successful targeted treatment options for Wnt/β-catenin - driven PCa are lacking. We report
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PD-L1 expression in ovarian clear cell carcinoma using the 22C3 pharmDx assay Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-15 Yike Gao, Boju Pan, Hongbao Jia, Yang Zhang, Shu Wang, Yuming Wang, Sumei Zhang, Mei Li, Anqi Wang, Xiaoxi Wang, Kun Zhao, Zixin Zhang, Jian Sun, Dan Guo, Zhiyong Liang
Ovarian clear cell carcinoma (OCCC), well known for its chemoresistance to platinum-based chemotherapy, exhibited a good response in clinical trials of anti–PD-1/PD-L1 inhibitors. By assessing PD-L1 expression, we sought to determine the potential therapeutic benefit of PD-1/PD-L1 inhibitors in OCCC. The retrospective study included 152 individuals with OCCC between 2019 and 2022 at Peking Union Medical
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Urachal mixed adenocarcinoma and small cell neuroendocrine carcinoma with widespread metastasis and resistance to chemotherapy: a case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-14 Sarah Obiedat, Khaled Murshed, Lajos Szabados, Khaled Al Rumaihi, Issam Al Bozom
Neuroendocrine carcinoma arising from the urachus is extremely rare. We describe a case of a 33-year-old gentleman who presented with hematuria and diagnosed to have a composite adenocarcinoma and small cell neuroendocrine carcinoma arising from the urachus. The patient also had widespread metastasis at the time of presentation, therefore, he was referred for chemotherapy. However, the disease showed
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Report of intraosseous intravascular papillary endothelial hyperplasia associated with an odontogenic cyst in the maxilla and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-12 Mateus José Dutra, Ana Lia Anbinder, Christyan Moretti Pereira, Beatriz Afonso Chiliti, André Caroli Rocha, Estela Kaminagakura
Intravascular papillary endothelial hyperplasia (IPEH) represents an uncommon reactive endothelial hyperplastic proliferation. A 46-year-old man experienced increased volume in the right maxilla, elevation of the nasal ala, and swelling of the hard palate with a reddish hue for 3 months. Computed tomography revealed an expansive hypodense region and cortical bone destruction associated with an impacted
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PSMD14 is a novel prognostic marker and therapeutic target in osteosarcoma Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-11 Jiabin Lai, Weike Kong, Qiangchang Fu, Zhaochang Jiang, Bohao Sun, Xin Ye, Jing Kong, Shumei Wei, Lifeng Jiang
Osteosarcoma is a bone tumor that is characterized by high malignancy and a high mortality rate, and that originates from primitive osteoblastic mesenchymal cells and is most common in rapidly growing long bones. PSMD14, also known as RPN11 or POH1, is a member of the JAMM isopeptidase family, which is able to remove the substrate protein ubiquitination label, thereby regulating the stability and function
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Inflammatory rhabdomyoblastic tumor, pheochromocytoma, and pulmonary hamartoma in a patient with neurofibromatosis type 1: a case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-11 Otto Jokelainen, Heidi Myllykangas, Katri Rajala, Jarkko Marttila, Reijo Sironen
Inflammatory rhabdomyoblastic tumors are relatively recently recognized soft tissue tumors with a low malignant potential. Here, we present a case of concurrent inflammatory rhabdomyoblastic tumor (IRMT), adrenal pheochromocytoma, and pulmonary hamartoma in a patient with neurofibromatosis type 1 (NF1). To our knowledge, this is the first time that this constellation of tumors has been described in
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B7-H3 and ICAM-1 are potentially therapeutic targets for thyroid carcinoma Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-10 Pengtao Song, Yongcan Xu, Guochao Ye
Although most differentiated thyroid carcinoma has a clinically favorable prognosis, some of specific types of thyroid cancer (such as anaplastic thyroid carcinoma and advanced papillary thyroid carcinoma) show fatal outcomes and require novel treatments. Immunotherapy is a promising avenue for the treatment of advanced thyroid carcinoma. B7-H3 (B7 homolog 3 protein) and ICAM-1 (intercellular adhesion
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CIC::NUTM1 sarcomas occurred in soft tissues of upper limbs : a rare case report and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-08 Lina Zhao, Huihua He, Jiacai Ren, Yabing Huang, Honglin Yan, Jingping Yuan
CIC-rearranged sarcomas (CRS) represent a new entity of undifferentiated small round cell sarcoma belonging to the Ewing-like sarcomas family. CRS are the most common type. Fusion partners for the CIC gene include DUX4, FOXO4, and the recently recognizedNUTM1. Rare cases of CIC::NUTM1 sarcoma in pediatric patients have recently been reported in brain, kidney, bone, and soft tissues. However, such cases
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Automatic analysis of nuclear features reveals a non-tumoral predictor of tumor grade in bladder cancer Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-08 Ibrahim Fahoum, Shlomo Tsuriel, Daniel Rattner, Ariel Greenberg, Asia Zubkov, Rabab Naamneh, Orli Greenberg, Valentina Zemser-Werner, Gilad Gitstein, Rami Hagege, Dov Hershkovitz
Tumor grade determines prognosis in urothelial carcinoma. The classification of low and high grade is based on nuclear morphological features that include nuclear size, hyperchromasia and pleomorphism. These features are subjectively assessed by the pathologists and are not numerically measured, which leads to high rates of interobserver variability. The purpose of this study is to assess the value
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POEMS syndrome with undetectable M-protein: a case report and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-07 Han-Yue Xue, Lin Zhou, Qin-Zhao Yuan, Yang Zhang, Yi-Qun Hao, Shao-Wei Chen, Hong-Kun Wang, Fang Wei
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare plasma cell (PC) neoplasm with associated paraneoplastic syndrome. According to the current diagnostic criteria, peripheral polyneuropathy and monoclonal PC proliferative disorder represent two mandatory criteria. We report a 54-year-old male with peripheral neuropathy of bilateral lower limbs, sclerotic
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Next-generation sequencing of primary testicular lymphoma and relapse in the glans penis after prophylactic radiation therapy: a rare case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-03 Naoya Ishibashi, Yoko Nakanishi, Toshiya Maebayashi, Katsuhiro Miura, Sumie Ohni, Shinobu Masuda, Yasuo Amano, Masahiro Okada
Primary testicular lymphoma (PTL) is relatively rare. The contralateral testis is a common site of PTL relapse; therefore, once complete remission is achieved, radiation therapy (RT) is administered to the contralateral testis to prevent relapse. A 76-year-old man was diagnosed with PTL and received RT as described above. However, despite achieving and maintaining complete remission, a mass diagnosed
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Cytological diagnosis of patients with embryonal rhabdomyosarcoma of the cervix: case report and literature review Diagn. Pathol. (IF 2.4) Pub Date : 2024-06-03 Xiaoxia Wei, Lei Li
Cervical embryonal rhabdomyosarcoma(ERMS) is a rare malignancy. To date, no cases of ERMS diagnosed by cervical cytology have been reported. In this study, we report a case of cervical ERMS identified by a liquid-based cytology test and cell blocks in a 46-year-old postmenopausal woman. We describe the cytological features of ERMS, with the aim of helping cytopathologists recognize this rare cervical
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Diagnostic and prognostic assessments of adrenocortical carcinomas by pathological features, immunohistochemical markers and reticular histochemistry staining Diagn. Pathol. (IF 2.4) Pub Date : 2024-05-27 Wenting Gan, Xue Han, Yuxi Gong, Yefan Yang, Cong Wang, Zhihong Zhang
Current diagnostic criteria of adrenocortical neoplasms are mostly based on morphology. The utility of immunohistochemistry (IHC) and histochemistry is limited. To evaluate the diagnostic and prognostic utility of clinicopathological features, morphology, ancillary biomarkers, and reticular histochemistry in adrenocortical neoplasms. We examined 28 adrenocortical carcinomas (ACCs) and 50 adrenocortical
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Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples Diagn. Pathol. (IF 2.4) Pub Date : 2024-05-25 James P. Solomon, Carlos Munoz-Zuluaga, Cheyanne Slocum, Alicia Dillard, Lin Cong, Jiajing Wang, Neal Lindeman, Michael Kluk, Benjamin Liechty, David Pisapia, Hanna Rennert, Priya D. Velu
IDH1 and IDH2 mutational status is a critical biomarker with diagnostic, prognostic, and treatment implications in glioma. Although IDH1 p.R132H-specific immunohistochemistry is available, it is unable to identify other mutations in IDH1/2. Next-generation sequencing can accurately determine IDH1/2 mutational status but suffers from long turnaround time when urgent treatment planning and initiation
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Thyroid papillary carcinoma combined with primary follicular lymphoma: a case report Diagn. Pathol. (IF 2.4) Pub Date : 2024-05-21 Ting Xu, Li Wu, Hua Ye, Shuai Luo, Jinjing Wang
Papillary thyroid carcinoma (PTC) stands out as the most prevalent epithelial malignant thyroid tumor. Thyroid primary follicular lymphoma (PFL) represents a rare malignant tumor originating from mesenchymal tissues. The concurrent occurrence of PTC and PFL is exceptionally rare, particularly in the context of Hashimoto’s thyroiditis, presenting significant challenges in clinical diagnosis and treatment
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Proposed diagnostic and prognostic markers of primary malignant hepatic vascular neoplasms Diagn. Pathol. (IF 2.4) Pub Date : 2024-05-13 Youngeun Yoo, Jinho Shin, Eunsung Jun, Eun-Young Koh, Hwa Jeong Shin, Hyo Jeong Kang
Primary malignant hepatic vascular tumors with various malignant potentials include epithelioid hemangioendothelioma (EHE) and angiosarcoma (AS), which may overlap pathologically. This study aimed to compare the pathological findings of hepatic EHE with those of AS, in association with patient outcomes. Fifty-nine histologically confirmed patients with 34 EHE and 25 AS were admitted to a tertiary hospital