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The possible protective effect of ginger extract on toxic changes induced by bisphenol A on the thyroid gland of adult male albino rats: light and electron microscopic study. Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-08-27 Sara Mohammed Taha Denewer,Safinaz Moustafa Mahmoud Ali,Nawal Awad Hasanin,Dalia Refat El-Bassouny
Bisphenol A (BPA) is a chemical substance used in the plastic industry and considered as an endocrine disruptor. Ginger is a herbal material used in the food industry and has antioxidant activity. The present study was performed to evaluate the histological changes in the thyroid gland of adult male albino rats after intake of BPA and if there is any protective role for ginger extract (GE). Eighty
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Features that characterize monoclonal light chain ("myeloma") cast nephropathy with immunofluorescence challenges and emphasis on electron microscopy. Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-08-21 Guillermo A Herrera,Luan D Truong,Sadhna Dhingra,Elba A Turbat-Herrera
Renal disease is a common cause of morbidity and mortality in patients with plasma cell dyscrasias. The serum-free light chain assay is used in patients, mostly older, with unexplained acute kidney injury to screen for potential myeloma cast nephropathy. This study consists of a systematic review of diagnostic features in myeloma cast nephropathy. The morphological features of tubular casts in patients
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Excessive lipid production shapes glioma tumor microenvironment Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-08-19 Haitham H. Maraqah, John Paul Aboubechara, Mones S. Abu-Asab, Han Sung Lee, Orwa Aboud
Disrupted lipid metabolism is a characteristic of gliomas. This study utilizes an ultrastructural approach to characterize the prevalence and distribution of lipids within gliomas. This study made ...
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Reactivation of nucleases with peroxidation damages induced by a menadione: ascorbate combination devastates human prostate carcinomas: ultrastructural aspects Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-08-06 Jacques Gilloteaux, James M Jamison, Jack L Summers, Henryk S Taper
Xenografts of androgen-independent human DU145 prostate metastatic carcinomas implanted in nu/nu male mice have revealed a significant survival after a prooxidant anticancer treatment consisting of...
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Ameliorative effects of gallic acid on tebuconazole–induced adverse effects in the cerebellum of adult albino rats: histopathological and immunohistochemical evidence Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-08-06 Omnia I. Ismail, Hala Mohamed Hassanin
Tebuconazole (TEB) is a common triazole sterol demethylation inhibitor fungicide utilized to manage a variety of diseases in crops like cereals, fruits, and vegetables. The aim of this work was to ...
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The potential protective effect of propolis on diabetic nephropathy induced by streptozotocin in adult albino rats Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-08-01 Shaimaa M. Hafez, Heba F. Ibrahim, Shaimaa R. Abdelmohsen, Noha A. E. Yasin, Yara S. Abouelela, Heba Abdelnaser Aboelsoud
Diabetes mellitus is a common metabolic disorder. It is associated with serious life-threatening complications if not properly managed. The current study aimed at investigating the possible protect...
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Emperipolesis in pleural fluid mesothelial cells. A phenomenon not associated with Rosai-Dorfman disease, report of a case Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-07-30 Diana Sofía Vargas-Lías, Mónica Lizette Serrano-Arévalo, Lara-Torres César, Corredor-Alonso Guillermo Ernesto, Hugo R. Dominguez-malagon
Emperipolesis is a cell-within-cell phenomenon distinct from phagocytosis more often described in Rosai-Dorfman disease, where usually lymphocytes or other bone marrow cells (plasma cells, erythrob...
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The potential therapeutic effects of exosomes derived from bone marrow mesenchymal stem cells on ileum injury of a rat sepsis model (histological and immunohistochemical study) Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-07-01 Heba M. Elnegris, Abeer A. Abdelrahman, Eman S. El-Roghy
Sepsis denotes a serious high mortality concern. The study was designed to evaluate the effect of mesenchymal stem cell exosomes (MSC-exosomes) on the evolution of the animal model of sepsis. In th...
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The effects of the combination of temozolomide and Eribulin on T98G human glioblastoma cell line: an ultrastructural study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-06-25 Gamze Tanriverdi, Belisa Kaleci, Furkan Yavuz, Hakan Sahin, Merjem Purelku, Zeliha Yazici, Sibel Kokturk
Glioblastoma tumors are the most aggressive primary brain tumors that develop resistance to temozolomide (TMZ). Eribulin (ERB) exhibits a unique mechanism of action by inhibiting microtubule dynami...
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Morphological and histopathological changes of maternal levetiracetam on the cerebellar cortex of the offspring of albino rat Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-06-08 Safaa M. Hanafy
Levetiracetam (LEV) is being used by women with reproductive-age epilepsy at a significantly higher rate. The purpose of the study was to assess how levetiracetam treatment during pregnancy affecte...
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Chronic liver fibrosis induction in aging causes significant ultra-structural deterioration in liver and alteration on immune response gene expressions in liver-spleen axis Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-06-06 Zeynal Mete Karaca, Gamze Karaca, Başak Kayhan, Mehmet Gül, Veysel Ersan, Harika Gözükara Bağ, Elif Yeşilada
The relationship between damage to the liver and spleen by aging and the immune response status in these two organs, which are anatomically and immunologically interconnected, is unknown. The autho...
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Can the analysis of chromatin texture and nuclear fractal dimensions serve as effective means to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features from other malignancies with follicular pattern in the thyroid?: a study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-06-03 Geet Bhuyan, Anjumoni Rabha
Thyroid carcinoma ranks as the 9th most prevalent global cancer, accounting for 586,202 cases and 43,636 deaths in 2020. Computerized image analysis, utilizing artificial intelligence algorithms, e...
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Unveiling renal pathology’s potential: exploring a rare subtype of amyloid – apolipoprotein CII amyloidosis in the youngest patient: a case report and literature review Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-05-20 Yiqin Zuo, Fiona Hanly, Duo Li, Efren Chavez, Omar Aljuboori, Gabriel Contreras, Guillermo A. Herrera
In this clinical case report, we present a rare subtype of amyloidosis, apolipoprotein CII (apo CII), which was diagnosed through a renal biopsy and subsequently confirmed by identifying the p.K41T...
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Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-05-16 Bangchen Wang, Micah Schub, Derrick L. Robinson, David N. Howell
Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typical...
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Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-04-29 Ping L. Zhang, Brandon D. Metcalf, Sarang Khan, Jamal Abukhaled, Khalid Zafar, Wei Li, Hassan D. Kanaan
IgM-dominant immune complex-mediated glomerulonephritis (IgM-dominant ICMGN) is a rare renal entity, characterized by a membranoproliferative pattern by light microscopy, dominant IgM staining by i...
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Metformin modulates autophagic pathway in renal fibrosis induced by carbon tetrachloride in adult male albino rats Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-04-23 Amal T. Abou-Elghait, Rania M. Al Adly, Eman Radwan, Fatma Y. Meligy
Chronic kidney disease (CKD) is a global public health problem. All progressive chronic kidney disease (CKD) is characterized by tubulointerstitial fibrosis. Exposure to high concentrations of carb...
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“Ultrastructural changes of platelets in COVID-19 and chronic viral hepatitis patients “ Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-04-15 Ayat SalahEldin Mohamed Hassan, Sahar Samir Abdelmaksoud Abo Gaziah, Hieba Gamal Ezzelregal Awad, Salma Mohammed Hegab Abdelhady, Nagwa Abbdelkhalek Talaat Elkhafif, Noha Bassiouny Hassan Mostafa
Platelet-viral interactions are evolving as a new concern. Coagulation disorder is a major consequence of the COVID-19 infection. In chronic hepatitis virus infections, defect in coagulation factor...
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Malformation of the endoplasmic reticulum system evolving into giant inclusions and Auer bodies in acute promyelocytic leukemia: an ultrastructural study of 6 cases Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-04-15 Yong-Xin Ru, Shu-Xu Dong, Jing Liu, Jin-Hua Liu, Yuan Zhou, Brian Eyden
The endoplasmic reticulum(ER)is the largest membranous network serving as a region for protein, lipid and steroid synthesis, transport and storage. Detailed information about ER-cisternae, ER-tubul...
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Robert Erlandson obituary (September 4, 1937-February 4, 2024): a true giant and great champion of ultrastructural pathology Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-03-31 David M. Parham
Published in Ultrastructural Pathology (Vol. 48, No. 3, 2024)
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Effect of platelet rich plasma versus melatonin on testicular injury induced by Busulfan in adult albino rats: a histological and immunohistochemical study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-29 Eman M. Askar, Amira M. Abdelmegid, Laila M. Elshal, Mohamed A. Shaheen
This study was done to estimate the testicular histological alterations induced by Busulfan (BUS) and compare the possible protective effects of melatonin (MT) and platelet rich plasma (PRP) in a r...
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Effect of peripheral blood mononuclear cells on ischemia-reperfusion injury of sciatic nerve of adult male albino rat: histological, immunohistochemical, and ultrastructural study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-29 Shaimaa Mostafa Kashef, Suzan Elsayed Abo Elnasr
Ischemia/reperfusion (I/R) injury of sciatic nerve is a serious condition that results in nerve fiber degeneration, and reperfusion causes oxidative injury. Peripheral blood mononuclear cells (PBMN...
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Ultrastructural differences between synovial sarcoma and solitary fibrous tumor: comparative study in adult patients from the National Cancer Institute of Mexico Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-13 Guillermo Ernesto Corredor-Alonso, Leonardo Saúl Lino-Silva, Erika Yazmin López-Flores, Tatiana Velásquez-Tovar, Hugo Ricardo Domínguez-Malagón
Synovial sarcoma (SS) and solitary fibrous tumor (SFT) are entities with considerable morphological and immunohistochemical similarities that sometimes show a non-confirmatory profile (TLE1 negativ...
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Correction Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07
Published in Ultrastructural Pathology (Vol. 48, No. 2, 2024)
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The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07 John M. Carney, Thomas A. Sporn, Victor L. Roggli, Elizabeth N. Pavlisko
Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been ...
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Morphometric, biochemical and histopathological effects of sofosbuvir (sovaldi) on testes of adult male albino rats Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07 Safaa M. H. Abdelaziz
Sofosbuvir treatment regimens for chronic HCV infection have recently been linked to extra hepatic side effects. This study aimed to show how sofosbuvir affected the adult male albino rat testis. F...
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Microstructural changes in the irradiated and osteoradionecrotic bone: a SEM study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07 P Sridhar Reddy, Kaapo Villikka, Bina Kashyap, Hannah Dekker, Engelbert A.J.M. Schulten, Jopi J.W. Mikkonen, Mikael Turunen, Arto P. Koistinen, Nathalie Bravenboer, Arja M. Kullaa
Radiation exposure is a major health concern due to bone involvement including mandible, causing deleterious effects on bone metabolism, and healing with an increasing risk of infection and osteora...
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Punctate IgG staining particles localize in the budding ballooning clusters of reactive foot processes in minimal change disease Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07 Ping L. Zhang, Vasudevan D. Mahalingam, Brandon D. Metcalf, Yazan A. Al-Othman, Wei Li, Hassan D. Kanaan, Guillermo A. Herrera
The etiology of minimal change disease (MCD) remains a mystery as the only characteristic findings are the diffuse effacement of foot processes seen on electron microscopy (EM). Punctate IgG staini...
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The Protective effects of Vitamin E against alterations of rat testis structure induced by deltamethrin; histological, ultrastructure, and biochemical study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07 Ghada Nady Ouais, Sherif A. Kamar, Ali Ahmed Mousa, Mohamed Mostafa Sonbol
Deltamethrin is a widely used synthetic pyrethroid pesticide. It causes reproductive toxicity. Aim of the work: it evaluates the impact of vitamin E in restoration of the testicular integrity of al...
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Protective effects of Urtica dioica on the cerebral cortex damage induced by Potassium bromate in adult male albino rats Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-02-07 Abeer A. Mahmoud, Maha Zayed Mohamed, Ebtehal Z. Hassen
Potassium bromate is used in cheese production, beer making and is also used in pharmaceutical and cosmetic. It is a proven carcinogen as it is a strong oxidizing agent that generates free radicals...
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Myxoinflammatory fibroblastic sarcoma: ultrastructural study of 7 cases Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Guillermo Ernesto Corredor-Alonso, Claudia Haydee Sarai Caro-Sánchez, Hugo Ricardo Domínguez-Malagón
Since first described, several studies about Myxoinflammatory fibroblastic sarcomas (MIFS) have been published stating the clinicopathological, morphological and immunohistochemical features. Howev...
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Comparative effects of chemical and green zinc oxide nanoparticles in caprine testis: ultrastructural and steroidogenic enzyme analysis Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Sneha Bareja, Rajnesh Kumar Sharma
Recent advancements in nanotechnology has opened up enormous possibilities in diverse sectors such as industries, agriculture, environmental remediation, electronics, medicine and varied industries...
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Structural characterization and origin of surface vesicles in monocytes: another membranous pathway from cytoplasm to cell surface Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Yongxin Ru, Shuxu Dong, Jing Liu, Jinhua Liu, Brian Eyden
The monocytes in acute monocytic leukemia (AML-M5b) were analyzed by scanning and transmission electron microscopy (SEM and TEM) to understand more fully their structure and origin. By SEM, monocyt...
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Intracellular organelles remodeling in myocardial endotheliocytes in COVID-19: an autopsy-based study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Nataliya Bgatova, Sergey Savchenko, Alexei Lamanov, Iuliia Taskaeva, Boris Ayzikovich, Valentina Gritcinger, Andrey Letyagin, Maksim Korolev
It is known that the unfavorable outcome in patients infected with SARS-CoV-2 may be associated with the development of complications caused by heart damage due to the direct virus action. The mech...
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Comparative study between the effect of mesenchymal stem cells microvesicles versus ozone on induced liver injury in adult male albino rats (Histological & Immunohistochemical study) Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Samar R. Mohamed, Samaa M. El-Mahroky, Sara Mohamed Abdel Aal
Liver disease accounts for approximately 2 million deaths er year worldwide. Liver fibrisis results from chronic injury to the liver. If not effectively treated in time, liver fibrosis may transfor...
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Investigation the effects of 2-aminoethoxydiphenyl borate (2-APB) on aminoglycoside nephrotoxicity Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Özge Kendirlinan, Yurdun Kuyucu, Bilge Güzelel, Ebru Dündar Yenilmez, Abdullah Tuli, Gülşah Seydaoğlu, Ufuk Özgü Mete
Investigation the protective effect of transient receptor potential channel modulator 2-Aminoethoxydiphenyl Borate (2-APB) on aminoglycoside nephrotoxicity caused by reactive oxygen species, calciu...
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Structural changes in testes of Streptozotocin induced diabetic rats and possible protective effect of royal jelly: light and electron microscopic study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2024-01-09 Eman A. El Helew, Wafaa S. Hamed, Amal M. Moustafa, Zeinab A. Sakkara
Diabetes mellitus (DM) is one of the most common metabolic diseases causing damage in many organs in the body including the testes. Royal Jelly (RJ) is one of the honey bee products that has antiox...
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The Sonic hedgehog pathway inhibitor GDC0449 induces autophagic death in human Medulloblastoma Daoy cells Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-11-30 Qi Zhang, Wanjing Zou, Longtao He, Cuiping Zhang, Ying Wang
Medulloblastoma (MB) is a frequently occurring malignant brain tumor in children, and many of these tumors are identified by the abnormal activation of the Sonic Hedgehog (SHH) pathway. Although th...
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Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-11-30 Maxine Draper, Megan Jean Bester, Mia-Jeanne Van Rooy, Hester Magdalena Oberholzer
Exposure to environmental metal pollutants is linked to oxidative stress and the subsequent development of neurological disease. In this study, the effects of copper, manganese, and mercury, were e...
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Morphologically and karyotypically atypical cells of ‘normal’ human bronchial epithelial cell line (Beas-2B) Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-11-30 Younsu Lee, Young-Joon Ryu
Beas-2B is an adenovirus 12-SV40-transfected cell line of “normal” human bronchial epithelial cells. This cell line was able to replace normal human bronchial epithelial cells, which are currently ...
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Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-11-30 George Terinte-Balcan, Simona Cinca, Simona Stancu, Mihaela Gherghiceanu, Gabriel Stefan
In this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lup...
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Involvement of small leucine-rich proteoglycans and telocytes in thin and thick human endometrium: immunohistochemical and ultrastructural examination Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-11-30 Ozlem Karabay Akgul, Tugba Ekiz-Yilmaz
Thin endometrium, defined as an endometrial thickness of less than 7 mm during the late follicular phase, is a common cause of frequent cancelation of embryo transfers or recurrent implantation fai...
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The possible protective role of selenium on the visual cortex of adult albino rat on exposure to potassium dichromate Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-11-30 Sally S. Anwer, Hala Mohamed Hassanin
The visual cortex is very important in mammals for processing of visual information. Exposure to heavy metals such as potassium dichromate poses serious health threat to human beings. The aim of th...
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A closer look: ultrastructural evaluation of high-risk progression IgA nephropathy Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-09-12 George Terinte-Balcan, Gabriel Stefan
This retrospective, cross-sectional study sought to examine the ultrastructural characteristics of glomerular lesions using Transmission Electron Microscopy (TEM) in IgA nephropathy (IgAN) and thei...
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Correction Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-09-06
Published in Ultrastructural Pathology (Vol. 47, No. 6, 2023)
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Lung cancer patient with Tropheryma whipplei and Nocardia co-infection Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-08-02 Yuli Zhou, Nan Yang, Senlin Ruan, Shenghai Wu, Daojun Yu, Juan Jin
ABSTRACT A 34-year-old male presented with lung shadow and was asymptomatic during medical examination. The patient had a prior history of thyroid tumors. Imaging manifestation showed a nodule in the medial segment of the right middle lobe, with partial obstruction of the distal bronchus within the lesion. Ground-glass and inflammatory nodules were observed in the anterior segment of the right upper
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Loss of Ephaptic Contacts in the Murine Thalamus during Osmotic Demyelination Syndrome Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-07-21 Jacques Gilloteaux, Kathleen De Swert, Valérie Suain, Jean-Pierre Brion, Charles Nicaise
ABSTRACT Background and aim A murine model mimicking osmotic demyelination syndrome (ODS) revealed with histology in the relay posterolateral (VPL) and ventral posteromedial (VPM) thalamic nuclei adjoined nerve cell bodies in chronic hyponatremia, amongst the damaged 12 h and 48 h after reinstatement of osmolality. This report aims to verify and complement with ultrastructure other neurophysiology
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Podocytopathies related to either COVID-19 infection or its vaccination, our experience and literature review Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-07-18 Ashbita Pokharel, Jessica D. Anderson, Mustafa Deebajah, Neal B. Blatt, Gampala Reddy, Vamshi Garlapaty, Wei Li, Hassan D. Kanaan, Ping L. Zhang
ABSTRACT Coronavirus disease 2019 (COVID-19) affects several organs including the kidney resulting in acute kidney injury (AKI) and variants of podocytopathies. From the beginning to the middle period of the COVID-19 pandemic, we have collected eight renal biopsies with various renal diseases including 4 podocytopathies. In addition, from the middle period to the near end of the COVID-19 pandemic,
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The impact of busulfan on the testicular structure in prepubertal rats: A histological, ultrastructural and immunohistochemical study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-07-16 Reem Ibrahim Abd El-Hay, Walaa H.E. Hamed, Nesreen Mostafa Omar, Dalia Refat El-Bassouny, Salwa A. Gawish
ABSTRACT Busulfan is a widely used cancer chemotherapeutic agent. Temporary or permanent sterility in male patients is one of the most common side effects of this drug. The present study was performed to evaluate the changes in the microscopic structure of the testes of prepubertal rats, as well as the changes in PCNA and caspase-3 immune expression, at different durations after busulfan administration
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Anti-phospholipase A2 receptor positive membranous nephropathy: investigating the link between electron microscopy stages and clinical outcome Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-07-14 Gabriel Stefan, George Terinte Balcan, Nicoleta Petre, Simona Cinca, Adrian Zugravu, Simona Stancu
ABSTRACT This retrospective, observational study sought to examine the relationship between Ehrenreich-Churg electron microscopy (EM) stages and long-term outcomes in anti-PLA2R membranous nephropathy (MN). Seventy-one patients with anti-PLA2R MN (median titer 185.7RU/mL) were followed for a median of 46 months, with end-stage kidney disease (ESKD) as the primary endpoint, and response to treatment
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Cilia impairment in bronchial epithelial cells detected in autopsy material of SARS-CoV-2-infected patient Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-06-12 Daria M. Potashnikova, Tatiana N. Sotnikova, Olesya M. Shirokova, Oleg V. Zayratyants, Elena Yu. Vasilieva, Eugene V. Sheval
ABSTRACT Recent studies indicate that cilia impairment, accompanied by the axonema loss and the basal body misorientation, is a common pathological feature of SARS-CoV-2-infected bronchial epithelial cells. However, these data were obtained using either cultured cells, or animal models, while in human postmortem material, cilia impairment has not been described yet. Here, we present direct observation
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The effects of cisplatin and jaceosidin on SH-SY5Y neuroblastoma cells: an electron microscopic, molecular and biochemical study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-29 Pinar Bayram, Selina Aksak Karamese, Bengul Özdemir, Aysegul Durak, Deniz Billur
ABSTRACT In this study, our aim was to show both the single and combined effects of cisplatin and jaceosidin in SHSY-5Y neuroblastoma cells. For this purpose, we used MTT cellular viability assay, Enzyme-Linked Immunosorbent Assay (ELISA), Transmission Electron Microscopy (TEM), Immunofluorescence Staining Assay (IFA) and Western blotting (WB) assay. According to MTT findings, IC50 dose was detected
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Histological and electron microscopic features of the extracellular matrix of invasive breast ductal carcinoma of no special type. Report of 5 cases and literature review Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-09 M.V. Mnikhovich, A.V. Romanov, T.M. Nguyen, T.V. Bezuglova, D.A. Pastukhova
ABSTRACT Invasive ductal carcinoma of no special type is the most common type of breast cancer. In light of the above, many authors have reported the histological and electron microscopic characteristics of these tumors. On the other hand, a limited number of works exist where the authors have concentrated on investigating the extracellular matrix. This article presents data received as the results
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Ultrastructural analysis of nucleated erythrocyte in patients with autoimmune hemolytic anemia (AIHA) Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-09 Jing Liu, Shuxu Dong, Yongxin Ru
ABSTRACT Autoimmune hemolytic anemia (AIHA) is a group of diseases characterized by immune-mediated lysis of mature red blood cells (RBCs). It is mainly classified into primary and secondary types based on etiology and mechanisms underlying autoantibody production. AIHA is diagnosed using morphological observation of bone marrow smears under a light microscope and monospecific direct antiglobulin test
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Astrocytoma and glioblastoma IDH1-wildtype cells colonize tumor vessels and deploy vascular mimicry Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-05 Haitham H. Maraqah, Mones S. Abu-Asab, Han Sung Lee, Orwa Aboud
ABSTRACT Gliomas are the most prevalent type of malignant brain tumors with a very dismal prognosis. Angiogenesis in glioma has recently gotten more attention and its molecular aspects have been published; however, these were not complemented with ultrastructural evidence. Our ultrastructural examination of glioma vessels reveals several unique and critical features related to their mechanisms of progression
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Morphological, biochemical, and histopathological effects of levetiracetam on pregnant albino rats and their offspring Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-03 Safaa M. H. Abdelaziz, Ranya Mohammed Abdelgalil, Shaimaa R. Abdelmohsen
ABSTRACT One of the most widely used medications for epilepsy is the broad-spectrum antiseizure levetiracetam. The study aimed to evaluate the impact of levetiracetam on the bodyweight and liver of pregnant rats and their offspring. The study involved treating the rats during pregnancy and lactation and then examining the pregnant rats and their offspring. Two groups of 40 pregnant rats were created
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Histological and biochemical evaluation of the effects of silver nanoparticles (AgNps) versus titanium dioxide nanoparticles (TiO2NPs) on rat parotid gland Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-03 Sara M. Abdel Aal, Maha Z. Mohammed, Abeer A. Abdelrahman, Walaa Samy, Ghadeer M. M. Abdelaal, Raghda H. Deraz, Shaimaa A. Abdelrahman
ABSTRACT The unlimited use of nanoparticles (NPs) results in toxic impacts on different tissues. The current study aimed to compare the adverse effects of AgNPs and TiO2NPs on the parotid gland of adult male albino rats as regards the histopathological, immunohistochemical, and biochemical changes, exploring the possible underlying mechanisms and the degree of improvement after cessation of administration
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The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study) Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-05-01 Ghada A Elsammak, Aliaa Talaat, Samar Reda
ABSTRACT Tributyltin is used in industrial applications. This current research aimed to study the effect of Tributyltin on the thyroid gland structure and function of adult male albino rats and the protective effect of Lycopene. Twenty-one male adult albino rats were classified into three groups: Control, treated that received Tributyltin, and protective that received Lycopene with Tributyltin. At
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An adrenal cortical adenoma with neuroendocrine-type granules mimicking pheochromocytoma Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-04-11 Leonardo Rossi, Carlo Enrico Ambrosini, Liborio Torregrossa, Maria Margherita de Santi, Raffaella Guazzo, Tommaso Simoncini, Alessandra Bacca, Benard Gjeloshi, Francesco Pignatelli, Mattia Iachini, Elisa Loguercio, Chiara Becucci, Gabriele Materazzi
ABSTRACT Clinical and biochemical presentation of adrenal tumors may rarely conflict with their histologic features. In the present report, we describe a rare case of adrenal neoplasm clinically and biochemically labeled as pheochromocytoma which at histologic examination resulted adrenal cortical tumor. The neoplasm was examined with the electron microscope which revealed the presence of electron-dense
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Human ovarian granulosa cells use clathrin-mediated endocytosis for LDL uptake: immunocytochemical and electron microscopic study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-04-10 Aynur Abdulova, Merjem Purelku, Hakan Sahin, Gamze Tanrıverdi
ABSTRACT The steroidogenic activity of the granulosa cells is important for the reproductive cycle, and lipoproteins are involved in this process. The clathrin-mediated endocytosis pathway for LDL transport is considered to be the main one in eukaryotic cells. However, there are no studies that elucidate LDL internalization in human granulosa cells clarifying whether the clathrin-mediated endocytic
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Could vitamin D protect against high fat diet induced damage in the arcuate nucleus in the rat: histological, immunohistochemical and ultrastructural study Ultrastruct. Pathol. (IF 1.1) Pub Date : 2023-03-29 Hala Mohamed Hassanin, Omnia I. Ismail
ABSTRACT Obesity is a serious health issue. As regard, the central nervous system, obesity induces neuronal damage. Vitamin D has well-known anti-inflammatory and neuroprotective effects. To detect if vitamin D protects against damage in the arcuate nucleus induced by a high fat-high fructose diet. Forty adult rats were used, and four groups were formed. Group I (negative control) kept on a standard