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Psychosis and schizophrenia among patients with epilepsy: A systematic review and meta-analysis Epilepsy Res. (IF 2.0) Pub Date : 2024-09-18 Sangharsha Thapa, Mohammad Yazdan Panah, Saeed Vaheb, Krishna Dahal, Prashanna Man Maharjan, Sangam Shah, Omid Mirmosayyeb
Prior research has indicated an association between epilepsy and psychosis. This review aimed to estimate the global prevalence rate of psychosis and schizophrenia in epilepsy and assess the odds of psychosis and schizophrenia among patients with epilepsy (PWE).
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Extracting seizure control metrics from clinic notes of patients with epilepsy: A natural language processing approach Epilepsy Res. (IF 2.0) Pub Date : 2024-09-10 Marta Fernandes, Aidan Cardall, Lidia MVR Moura, Christopher McGraw, Sahar F. Zafar, M.Brandon Westover
Monitoring seizure control metrics is key to clinical care of patients with epilepsy. Manually abstracting these metrics from unstructured text in electronic health records (EHR) is laborious. We aimed to abstract the date of last seizure and seizure frequency from clinical notes of patients with epilepsy using natural language processing (NLP). We extracted seizure control metrics from notes of patients
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The relationship between perceived stress, spiritual well-being and alexithymia in people with epilepsy: A path analysis Epilepsy Res. (IF 2.0) Pub Date : 2024-09-10 Yanmış Safiye, Bahçecioğlu Turan Gülcan, Özer Zülfünaz, Alevtina Ersoy
The present study was performed to investigate the associations among perceived stress, spiritual well-being, and alexithymia in people with epilepsy. The study was performed with 140 patients diagnosed with epilepsy in the neurology clinic of a training and research hospital between May and December 2022. Personal Information Form, Perceived Stress Scale (PSS-14), Spiritual Well-Being Scale (FACIT
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New onset status epilepticus and its long-term outcome: A cohort study Epilepsy Res. (IF 2.0) Pub Date : 2024-08-22 Sharath Adiga, Ravindranadh Chowdary Mundlamuri, Ajay Asranna, Lakshminarayanapuram Gopal Vishwanathan, Kenchaiah Raghavendra, Nandakumar Dalavaikodihalli Nanjaiah, PV Prathyusah, Karthik Kulanthaivelu, Sanjib Sinha
New onset status epilepticus (NOSE), a subtype of status epilepticus, is a neurological emergency associated with significant morbidity and mortality. This study aimed to analyze the phenotypic spectrum and outcomes of patients presenting with NOSE. This prospective and retrospective descriptive study included patients presenting with NOSE over a 10-year period. Data collected included patient demographics
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NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density Epilepsy Res. (IF 2.0) Pub Date : 2024-08-22 David A. Narvaiz, Katherine J. Blandin, D. Gregory Sullens, Paige D. Womble, Jacob B. Pilcher, Grace O’Neill, Taylor A. Wiley, Eliesse M. Kwok, Srikhar V. Chilukuri, Joaquin N. Lugo
Seizures induce hippocampal subregion dependent enhancements in microglia/macrophage phagocytosis and cytokine release that may contribute to the development of epilepsy. As a model of hyperactive mTOR induced epilepsy, neuronal subset specific phosphatase and tensin homolog (NS-) knockout (KO) mice exhibit hyperactive mTOR signaling in the hippocampus, seizures that progress with age, and enhanced
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Exploring seizure characteristics in individuals with autoimmune encephalitis: A comprehensive retrospective study in a low-middle-income country setting Epilepsy Res. (IF 2.0) Pub Date : 2024-08-22 S.S. Sánchez-Boluarte, W. Aguirre-Quispe, W. De La Cruz Ramirez, J. Tacunan-Cuellar, A. Vergaray-Loayza, L. Quintana-Garcia, M. Alfaro-Olivera, L. Nuñez Del Prado Murillo, C. Caparó-Zamalloa
Seizures and epilepsy are well-documented in association with autoimmune encephalitis. Despite this, a notable gap exists in understanding the persistence of seizures beyond the acute phase, particularly within the context of low- and low-middle-income settings. To evaluate the frequency, clinical characteristics, diagnosis, and potential factors associated with the occurrence and persistence of seizures
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A side-by-side comparison of fine-tuning options for treatment of medically refractory epilepsy: Antiseizure medications, vagus nerve stimulation and ketogenic diet therapies Epilepsy Res. (IF 2.0) Pub Date : 2024-08-17 Deana Bonno, Lisa Vanatta, Eric Kossoff
There are many treatment options available for patients with medically refractory epilepsy including antiseizure medications, surgery, devices and ketogenic diet therapy. Ketogenic diet therapy has been shown to be a safe and effective treatment option in adult and pediatric patients. In order to obtain maximal clinical effectiveness and tolerability of any treatment option, adjustments are often necessary
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Transcranial magnetic stimulation and magnetoencephalography are feasible alternatives to invasive methods in optimizing responsive neurostimulation device placement Epilepsy Res. (IF 2.0) Pub Date : 2024-08-08 J. Austin Varner, Roozbeh Rezaie, Negar Noorizadeh, Frederick A. Boop, Stephen P. Fulton, Paul Klimo, Nir Shimony, James W. Wheless, Shalini Narayana
Responsive neurostimulation (RNS) is a treatment option for patients with refractory epilepsy when surgical resection is not possible due to overlap of the irritative zone and eloquent cortex. Presurgical evaluations for RNS placement typically rely on invasive methods. This study investigated the potential of transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) to provide key presurgical
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Health insurance and transportation barriers impact access to epilepsy care in the United States Epilepsy Res. (IF 2.0) Pub Date : 2024-08-08 Brad K. Kamitaki, Shelly Maniar, Raaga Rambhatla, Kelly Gao, Joel C. Cantor, Hyunmi Choi, Michelle T. Bover Manderski
Inconsistent access to healthcare for people with epilepsy results in reduced adherence to antiseizure medications, increased seizure frequency, and fewer appropriate referrals for epilepsy surgery. Identifying and addressing factors that impede access to care should consequently improve patient outcomes. We hypothesized that health insurance and transportation affect access to outpatient neurology
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Differential contributions of performance-based and parental reports of executive functioning on memory in pediatric focal and generalized epilepsies Epilepsy Res. (IF 2.0) Pub Date : 2024-08-08 Bruna M. Schneider, Erica M. Krapf, Kathleen E. Hassara, Lisa D. Stanford, Dalin T. Pulsipher
Children with epilepsy often experience deficits in both executive functioning (EF) and memory. However, how these two domains interact and relate to specific epilepsy types remains unclear. This study compared two groups of children: those with localization-related epilepsy (LRE) and those with genetic generalized epilepsy (GGE). We aimed to understand how performance-based and parent-reported EF
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Do germline genetic variants influence surgical outcomes in drug-resistant epilepsy? Epilepsy Res. (IF 2.0) Pub Date : 2024-08-06 Paula Marques, Patrick B. Moloney, Caihong Ji, Quratulain Zulfiqar Ali, Archana Ramesh, David B. Goldstein, Karen Barboza, Ilakkiah Chandran, Marlene Rong, Arunan Selvarajah, Farah Qaiser, Victor S.T. Lira, Taufik A. Valiante, Carl W. Bazil, Hyunmi Choi, Orrin Devinsky, Chantal Depondt, Terence O’Brien, Piero Perucca, Arjune Sen, Patricia Dugan, Tristan T. Sands, Norman Delanty, Danielle M. Andrade
We retrospectively explored patients with drug-resistant epilepsy (DRE) who previously underwent presurgical evaluation to identify correlations between surgical outcomes and pathogenic variants in epilepsy genes. Through an international collaboration, we evaluated adult DRE patients who were screened for surgical candidacy. Patients with pathogenic (P) or likely pathogenic (LP) germline variants
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The utility of Multicentre Epilepsy Lesion Detection (MELD) algorithm in identifying epileptic activity and predicting seizure freedom in MRI lesion-negative paediatric patients Epilepsy Res. (IF 2.0) Pub Date : 2024-08-06 Aimee Goel, Stefano Seri, Shakti Agrawal, Ratna Kumar, Annapurna Sudarsanam, Bryony Carr, Andrew Lawley, Lesley Macpherson, Adam J. Oates, Helen Williams, A. Richard Walsh, William B. Lo, Joshua Pepper
Paediatric patients with drug-resistant focal epilepsy (DRFE) who have no clear focal lesion identified on conventional structural magnetic resonance imaging (MRI) are a particularly challenging cohort to treat and form an increasing part of epilepsy surgery programs. A recently developed deep-learning-based MRI lesion detection algorithm, the Multicentre Lesion Detection (MELD) algorithm, has been
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Factors linked with perceived stigma amid people with Epilepsy -across sectional study Epilepsy Res. (IF 2.0) Pub Date : 2024-08-06 Archana Verma, Pooja Pathak, Ashutosh Kumar Mishra, Sachin Upadhya
People with epilepsy (PWE) continue to suffer from discrimination and often bear the negative attitudes surrounding this condition. The aim of the study was to assess the frequency of perceived stigma and factors associated with it among PWE in tertiary care centre. A hospital-based, cross-sectional study was conducted using the Kilifi Stigma Scale of Epilepsy (KSSE) to assess the stigma associated
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Emergency department utilization among adults with epilepsy: A multi-state cross-sectional analysis, 2010–2019 Epilepsy Res. (IF 2.0) Pub Date : 2024-08-06 Lidia Moura, Ioannis Karakis, David Howard
We described patterns and trends in ED use among adults with epilepsy in the United States. Utilizing inpatient and ED discharge data from seven states, we conducted a cross-sectional analysis to identify adult ED visits diagnosed with epilepsy or seizures from 2010 to 2019. Using ED visit counts and estimates of state-level epilepsy prevalence, we calculated ED visit rates overall and by payer, condition
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Impact of seizure onset zone and intracranial electroencephalography ictal characteristics on epilepsy surgery outcomes in tuberous sclerosis complex Epilepsy Res. (IF 2.0) Pub Date : 2024-08-06 Kara B. Miecznikowski, James Leach, Leonid Rozhkov, Francesco T. Mangano, Jesse Skoch, Darcy A. Krueger, Paul S. Horn, Hansel M. Greiner
Ninety percent of tuberous sclerosis complex (TSC) patients have seizures, with ∼50 % developing drug refractory epilepsy. Surgical intervention aims to remove the seizure onset zone (SOZ). This retrospective study investigated the relationship of SOZ size, ictal pattern, and extent of resection with surgical outcomes. TSC patients undergoing resective/ablative surgery with >1-year follow-up and adequate
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Corrigendum to “An rs-fMRI based neuroimaging marker for adult absence epilepsy” [2024 204, 107400] Epilepsy Res. (IF 2.0) Pub Date : 2024-07-26 Ruoshi Liu, Guozhong Zhu, Yujun Gao, Dongbin Li
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Effects of acute administration of 4-allyl-2,6-dimethoxyphenol in mouse models of seizures Epilepsy Res. (IF 2.0) Pub Date : 2024-07-26 Leandro Rodrigo Ribeiro, Aline Matilde Ferreira dos Santos, Erika da Cruz Guedes, Thamires Lucena da Silva Bezerra, Thaíze Lopes de Souza, José Maria Barbosa Filho, Reinaldo Nóbrega de Almeida, Mirian Graciela da Silva Stiebbe Salvadori
Epilepsy, a chronic neurological disorder characterized by recurrent unprovoked seizures, presents a substantial challenge in approximately one-third of cases exhibiting resistance to conventional pharmacological treatments. This study investigated the effect of 4-allyl-2,6-dimethoxyphenol, a phenolic compound derived from various natural sources, in different models of induced seizures and its impact
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Role of berberine nanoformulation in epilepsy: A novel therapeutic strategy Epilepsy Res. (IF 2.0) Pub Date : 2024-07-18 Lekha Saha, Puja kumari, V.R. Sinha, Vipasha Gautam, Lavjot Kaur, Sunil Sharma, Amitava Chakrabarti
The aim of the present study was to develop a novel formulation of berberine (BBR) and demonstrate its anti-seizure effect in pentylenetetrazole (PTZ) induced kindling model in rats. Nanoparticles of BBR were formulated using Poly Lactic--Glycolic Acid (PLGA) as a polymer. Emulsification and solvent evaporation technique was used. PTZ induced kindling model in male wistar rat was used to demonstrate
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In-hospital outcomes in people with autism and epilepsy – A population-based study Epilepsy Res. (IF 2.0) Pub Date : 2024-07-14 Varun R. Subramaniam, Jonathan Goldstein, Lan Mu, Churl-Su Kwon
Autism is a common comorbid diagnosis in those with epilepsy. Understanding the health needs and outcomes in patients with this dual diagnosis is important for optimizing healthcare outcomes. We compared hospital-level variables amongst patients with co-occurring autism and epilepsy, to those with epilepsy alone. Non-elective hospital admissions amongst patients with epilepsy alone and co-occurring
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Hot water epilepsy with alone and spontaneous seizures in childhood Epilepsy Res. (IF 2.0) Pub Date : 2024-07-14 Sevgi Yimenicioğlu, Arzu Ekici
Hot water epilepsy (HWE) is a type of epilepsy that primarily affects children. This study was aimed to evaluate the clinical, electroencephalogram (EEG), neuroimaging findings, and treatment options in children with HWE. The medical records of 24 patients who had HWE were evaluated retrospectively. There were 2767 patients diagnosed with epilepsy during the seven-year period, and 0.86 % of the patients
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Acute seizures after spontaneous intracerebral hemorrhage in young individuals: 11-year trends and association with mortality Epilepsy Res. (IF 2.0) Pub Date : 2024-07-10 Alain Lekoubou, Austin Cohrs, Mariana Dejuk, Jinpyo Hong, Souvik Sen, Leonardo Bonilha, Vernon M. Chinchilli
The rate of spontaneous Intracerebral Hemorrhage (sICH) is rising among young Americans. Trends in acute seizure (AS) incidence in this age group is largely unknown. Further, the association of AS with mortality has not been reported in this age group. The aim of this study is to determine trends in AS among young individuals with sICH. The Merative MarketScan® Commercial Claims and Encounters database
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Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients Epilepsy Res. (IF 2.0) Pub Date : 2024-07-06 Amanda C. Mosini, Viviam Sanabria, Thábatta K.E. Nakamura, Michele L. Calió, Clara Pompeu, Clivandir S. Silva, Priscila Nicolicht-Amorim, Maria da Graça Naffah-Mazzacoratti, Marimelia A. Porcionatto, Luiz Eugênio Mello, Maira L. Foresti
This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE). Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Brazil. Clinical data and blood samples were collected after 10 days of hospitalization for posterior genetic
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Evaluation of seizure semiology, genetics, magnetic resonance imaging, and electroencephalogram findings in children with Rett syndrome: A multicenter retrospective study Epilepsy Res. (IF 2.0) Pub Date : 2024-07-06 Nihal Yıldız, Esra Serdaroğlu, Pınar Özkan Kart, Seyda Besen, Seda Kanmaz, Dilara Ece Toprak, Betul Kilic, Ozlem Ersoy, Pınar Gencpinar, Nihal Olgac Dundar, Cetin Okuyaz, Ayse Serdaroglu, Kursat Bora Carman, Coşkun Yarar, Barış Ekici, Burak Tatlı, İlknur Erol, Kürşad Aydın, Hasan Tekgül, Ali Cansu
This study aimed to evaluate seizure semiology, electroencephalogram (EEG), magnetic resonance imaging (MRI), and genetic findings, as well as treatment choices in Rett syndrome (RTT). A retrospective analysis was conducted on one hundred and twenty cases diagnosed with RTT with a genetic mutation. Data were obtained from nine participating centers. In this study, 93.3 % of patients were female, with
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Advancing thalamic neuromodulation in epilepsy: Bridging adult data to pediatric care Epilepsy Res. (IF 2.0) Pub Date : 2024-07-06 Debopam Samanta, Gewalin Aungaroon, Gregory W. Albert, Cemal Karakas, Charuta N. Joshi, Rani K. Singh, Chima Oluigbo, M. Scott Perry, Sunil Naik, Puck C. Reeders, Puneet Jain, Taylor J. Abel, Sandipan Pati, Ammar Shaikhouni, Zulfi Haneef
Thalamic neuromodulation has emerged as a treatment option for drug-resistant epilepsy (DRE) with widespread and/or undefined epileptogenic networks. While deep brain stimulation (DBS) and responsive neurostimulation (RNS) depth electrodes offer means for electrical stimulation of the thalamus in adult patients with DRE, the application of thalamic neuromodulation in pediatric epilepsy remains limited
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Hippocampal activations obtained during language fMRI tasks: A complementary tool for predicting postoperative memory prognosis Epilepsy Res. (IF 2.0) Pub Date : 2024-07-04 Eve Salleles, Séverine Samson, Marisa Denos, Marie Mere, Stéphane Lehericy, Bastien Herlin, Sophie Dupont
In medial temporal lobe epilepsy (MTLE), the benefits of surgery must be balanced against the risk of post-operative memory decline. Prediction of postoperative outcomes based on functional magnetic resonance imaging (fMRI) tasks is increasingly common but remains uncertain. The aim of this retrospective study was to determine whether hippocampal activations elicited by fMRI language tasks could enhance
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Localization of epileptogenic zone based on time-varying effective networks Epilepsy Res. (IF 2.0) Pub Date : 2024-07-02 Ning Yin, Yamei Han, Le Wang, Fan Yang, Jicheng Li, Guizhi Xu
Surgical resection of the epileptogenic zone (EZ) is an effective method for treating drug-resistant epilepsy. At present, the accuracy of EZ localization needs to be further improved. The characteristics of graph theory based on partial directed coherence networks have been applied to the localization of EZ, but the application of network control theory to effective networks to locate EZ is rarely
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A systematic review of electroencephalographic findings in Lennox-Gastaut syndrome Epilepsy Res. (IF 2.0) Pub Date : 2024-07-02 Firoz M. Nizami, Sweety Trivedi, Jayantee Kalita
Lennox–Gastaut syndrome (LGS) is a severe form of childhood onset epileptic encephalopathy characterized by multiple drug-resistant seizures, cognitive impairment, and diffuse slow spike and wave (SSW), and generalized paroxysmal fast activity (GPFA) on electroencephalogram (EEG). Systematic review following the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines
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A medico-legal perspective on postictal violence: A case study and systematic review of postictal delirium Epilepsy Res. (IF 2.0) Pub Date : 2024-07-02 Mark Quigg, Richard Bonnie, Derek Bauer, Howard P. Goodkin, Jaideep Kapur
Detailed descriptions of violent postictal episodes are rare. We provide evidence from an index case and from a systematic review of violent postictal episodes that demonstrates the encephalopathic features of some violent postictal behaviors. We discuss how these cases may fit in the legal framework of culpability. The data support the view that some episodes of violent postictal behavior are more
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Predicting efficacy of antiseizure medication treatment with machine learning algorithms in North Indian population Epilepsy Res. (IF 2.0) Pub Date : 2024-07-01 Mahima Kaushik, Siddhartha Mahajan, Nitin Machahary, Sarita Thakran, Saransh Chopra, Raj Vardhan Tomar, Suman S. Kushwaha, Rachna Agarwal, Sangeeta Sharma, Ritushree Kukreti, Bibhu Biswal
This study aimed to develop a classifier using supervised machine learning to effectively assess the impact of clinical, demographical, and biochemical factors in accurately predicting the antiseizure medications (ASMs) treatment response in people with epilepsy (PWE). Data was collected from 786 PWE at the Outpatient Department of Neurology, Institute of Human Behavior and Allied Sciences (IHBAS)
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Foramen ovale electrode investigation in the era of SEEG: Results and a reappraisal Epilepsy Res. (IF 2.0) Pub Date : 2024-06-28 Rohan Jha, Melissa MJ Chua, Noah Nawabi, Sydney S. Cash, John D. Rolston, Andrew J. Cole
Patients with medication-resistant disabling epilepsy should be considered for potential epilepsy surgery. If noninvasive techniques are unable to identify the location of the seizure onset zone (SOZ), it becomes necessary to consider intracranial investigations. Stereo-electroencephalography (SEEG) is currently the preferred method for such monitoring, however foramen ovale (FO) electrodes offer a
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Development and validation of an interpretable machine learning model for predicting post-stroke epilepsy Epilepsy Res. (IF 2.0) Pub Date : 2024-06-28 Yue Yu, Zhibin Chen, Yong Yang, Jiajun Zhang, Yan Wang
Epilepsy is a serious complication after an ischemic stroke. Although two studies have developed prediction model for post-stroke epilepsy (PSE), their accuracy remains insufficient, and their applicability to different populations is uncertain. With the rapid advancement of computer technology, machine learning (ML) offers new opportunities for creating more accurate prediction models. However, the
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An rs-fMRI based neuroimaging marker for adult absence epilepsy Epilepsy Res. (IF 2.0) Pub Date : 2024-06-28 Ruoshi Liu, Guozhong Zhu, Yujun Gao, Dongbin Li
Approximately 20–30 % of epilepsy patients exhibit negative findings on routine magnetic resonance imaging, and this condition is known as nonlesional epilepsy. Absence epilepsy (AE) is a prevalent form of nonlesional epilepsy. This study aimed to investigate the clinical diagnostic utility of regional homogeneity (ReHo) assessed through the support vector machine (SVM) approach for identifying AE
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AI in ECG: Validating an ambulatory semiology labeller and predictor Epilepsy Res. (IF 2.0) Pub Date : 2024-06-28 Pooja Muralidharan, Ravi Sankaran, Perraju Bendapudi, C. Santhosh Kumar, A. Anand Kumar
Early prediction of epileptic seizures can help reduce morbidity and mortality. In this work, we explore using electrocardiographic (ECG) signal as input to a seizure prediction system and note that the performance can be improved by using selected signal processing techniques. We used frequency domain analysis with a deep neural network backend for all our experiments in this work. We further analysed
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Morbidity Associated with Deviation from Pediatric Status Epilepticus Guidelines Epilepsy Res. (IF 2.0) Pub Date : 2024-06-18 Jillian Gregory, Andrew Cohen, Anya Cutler, Alexa Craig
Treatment guidelines for the management of pediatric status epilepticus (PSE) are often institution-specific. We aim to characterize deviation from our hospital-based PSE treatment guidelines, the total dosage of benzodiazepines administered, and the need for intubation. The study population included all patients with an ICD −10 code for PSE who required admission to the Pediatric Intensive Care Unit
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Quality of life during usual epilepsy care for anxiety or depression symptoms: Secondary patient-reported outcomes in a randomized trial of remote assessment methods Epilepsy Res. (IF 2.0) Pub Date : 2024-06-14 Heidi M. Munger Clary, Beverly M. Snively, Yaw Kumi-Ansu, Halley B. Alexander, James Kimball, Pamela Duncan, Kelly Conner, Jerryl Christopher, Paneeni Lohana, Gretchen A. Brenes
Anxiety and depression are highly prevalent and impactful in epilepsy. American Academy of Neurology quality measures emphasize anxiety and depression screening and quality of life (QOL) measurement, yet usual epilepsy care QOL and anxiety/depression outcomes are poorly characterized. The main objective was to assess 6-month QOL, anxiety and depression during routine care among adults with epilepsy
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Efficacy and tolerability of classical and polyunsaturated fatty acids ketogenic diet in controlling paediatric refractory epilepsy – A randomized study Epilepsy Res. (IF 2.0) Pub Date : 2024-06-13 Subhasree Ray, Janak Nathan, Meena Godhia
To measure and compare the efficacy and tolerability of a classical ketogenic diet (CKD) and a polyunsaturated fatty acids ketogenic diet (PUFAKD) in managing childhood refractory epilepsy. Efficacy was assessed by measuring the change in seizure frequency at 3, 6, 9, and 12 months within and between groups. The percentage reduction in seizures at <50 %, 50–90 %, >90 %, and 100 % was also measured
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Rat strain differences in seizure frequency and hilar neuron loss after systemic treatment with pilocarpine Epilepsy Res. (IF 2.0) Pub Date : 2024-06-13 Kristina Junghans, Megan Wyeth, Paul S. Buckmaster
At least 3 months after systemic treatment with pilocarpine to induce status epilepticus, Long-Evans and Sprague-Dawley rats were video-EEG monitored for seizures continuously for 1 month. Rats were then perfused, hippocampi were processed for Nissl staining, and hilar neurons were quantified. Seizure frequency in Long-Evans rats was 1/10th of that in Sprague-Dawley rats, and more variable. Hilar neuron
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Detection of short-lasting and ictal spike-and-wave discharges in around-the-ears EEG recordings in children with absence epilepsy Epilepsy Res. (IF 2.0) Pub Date : 2024-06-03 Silvano R. Gefferie, Pauly P.W. Ossenblok, Christoph S. Dietze, Armen Sargsyan, Mireille Bourez-Swart, Arn M.J.M. van den Maagdenberg, Roland D. Thijs
Long-term ambulatory EEG recordings can improve the monitoring of absence epilepsy in children, but signal quality and increased review workload are a concern. We evaluated the feasibility of around-the-ears EEG arrays (cEEGrids) to capture 3-Hz short-lasting and ictal spike-and-wave discharges and assessed the performance of automated detection software in cEEGrids data. We compared patterns of bilateral
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Retention rate of vagus nerve stimulation for the treatment of drug-resistant epilepsy: A single-centre, retrospective study. Epilepsy Res. (IF 2.0) Pub Date : 2024-05-21 Astrid Durez, Tom Theys, Johannes van Loon, Wim Van Paesschen
The aim of this single-centre, retrospective, observational study was to evaluate long-term effectiveness of vagus nerve stimulation (VNS) in drug-resistant epilepsy (DRE) by using retention rate as a surrogate measure for seizure reduction. We included all patients with DRE, treated at the adult neurology department of the University Hospitals Leuven and who started VNS therapy from January 1, 1994
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An analysis of suicidal and self-injurious behavior reports with antiseizure medications in the FDA adverse event database Epilepsy Res. (IF 2.0) Pub Date : 2024-05-17 Mokshal H. Porwal, Abrahim N. Razzak, Vinay Kumar, Ahmed Z. Obeidat, Umesh Sharma
Pharmacovigilance systems such as the FDA Adverse Event Reporting System (FAERS), are established models for adverse event surveillance that may have been missed during clinical trials. We aimed to analyze twenty-five anti-seizure medications (ASMs) in FAERS to assess for increased reporting of suicidal and self-injurious behavior. Twenty-five ASMs were analyzed: brivaracetam, cannabidiol, carbamazepine
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Conventional and novel anti-seizure medications reveal a particular role for GABAA in a North Sea progressive myoclonus Epilepsy Drosophila model Epilepsy Res. (IF 2.0) Pub Date : 2024-05-14 Sjoukje S. Polet, Tom J. de Koning, Roald A. Lambrechts, Marina A.J. Tijssen, Ody C.M. Sibon, Jenke A. Gorter
North Sea Progressive Myoclonus Epilepsy (NS-PME) is a rare genetic disorder characterized by ataxia, myoclonus and seizures with a progressive course. Although the cause of NS-PME is known, namely a homozygous mutation in the gene (c.430 G>T; p. Gly144Trp), sufficient treatment is lacking. Despite combinations of on average 3–5 anti-seizure medications (ASMs), debilitating myoclonus and seizures persist
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Serum HMGB1 in febrile seizures Epilepsy Res. (IF 2.0) Pub Date : 2024-05-10 Maria K. Hautala, Kirsi H. Mikkonen, Tytti M.L. Pokka, Sirpa K. Rannikko, Ulla V. Koskela, Heikki M.J. Rantala, Matti K. Uhari, Virpi Glumoff, Heli M. Helander
The role of high-mobility group box 1 (HMGB1) in the pathogenesis of febrile seizures (FSs) is unclear. In our controlled follow-up study, we compared serum levels of HMGB1 (s-HMGB1) in the same individuals after the first FS, during febrile episodes without a FS, after recurrent FS, during healthy periods after FS, and between patients and controls. In all, 122 patients with FSs were included in the
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Long-term seizure diary tracking habits in clinical studies: Evidence from the Human Epilepsy Project Epilepsy Res. (IF 2.0) Pub Date : 2024-05-08 Kristen R. Miller, Sarah Barnard, Elizabeth Juarez-Colunga, Jacqueline A. French, Jacob Pellinen, on behalf of the Human Epilepsy Project Investigators
To characterize seizure tracking patterns of people with focal epilepsy using electronic seizure diary entries, and to assess for risk factors associated with poor tracking. We analyzed electronic seizure diary data from 410 participants with newly diagnosed focal epilepsy in the Human Epilepsy Project 1 (HEP1). Each participant was expected to record data each day during the study, regardless of seizure
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Functional brain network analysis using electroencephalography in late-onset Lennox–Gastaut syndrome Epilepsy Res. (IF 2.0) Pub Date : 2024-05-06 Zhi Ji Wang, Soyoung Park, Heung Dong Kim, Hoon-Chul Kang, Nam-Young Kim, Yun Jung Hur
We aimed to explore the clinical characteristics and functional network properties of patients with late-onset Lennox–Gastaut syndrome (LGS). Late-onset LGS was defined by the appearance of LGS features after 8 years of age. We reviewed the medical charts of 9 patients with late-onset LGS, and performed electroencephalography connectivity analysis using graph theory. We assessed the clustering coefficient
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A meta-analysis of the relationship between abnormal pretreatment EEG and epilepsy recurrence Epilepsy Res. (IF 2.0) Pub Date : 2024-05-01 Juan Yao, Chengrong Liao, Yao Wang, Zheng Xiao
Researchers have studied the risk factors for epilepsy recurrence among patients who withdraw from antiseizure medication (ASM). These studies aimed to determine the optimal time for ASM withdrawal. EEG findings are one of the risk factors that has been studied. However, it remains unclear whether abnormal pretreatment EEG findings are a risk factor for recurrence after ASM withdrawal. We performed
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Surgical outcomes in children with drug-resistant epilepsy and hippocampal sclerosis Epilepsy Res. (IF 2.0) Pub Date : 2024-04-30 Ream Alashjaie, Elizabeth N. Kerr, Azhar AlShoumer, Cynthia Hawkins, Ivanna Yau, Shelly Weiss, Ayako Ochi, Hiroshi Otsubo, Pradeep Krishnan, Elysa Widjaja, George M. Ibrahim, Elizabeth J. Donner, Puneet Jain
Hippocampal sclerosis (HS) is a common surgical substrate in adult epilepsy surgery cohorts but variably reported in various pediatric cohorts. We aimed to study the epilepsy phenotype, radiological and pathological variability, seizure and neurocognitive outcomes in children with drug-resistant epilepsy and hippocampal sclerosis (HS) with or without additional subtle signal changes in anterior temporal
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Clinical and sociodemographic characteristics of patients with epilepsy attended at a regional reference psychiatric emergency unit Epilepsy Res. (IF 2.0) Pub Date : 2024-04-28 Bruno Soleman Maritan, Giovanna Favaretto, Bruna Tarifa, Fernanda Menezes de Faria, Leonardo Ferreira Antônio, Mayra Folgosi Ricci, Gerardo Maria de Araújo Filho
Epilepsy is one of the most prevalent chronic neurological diseases, presenting a high frequency of psychiatric disorders (PD). This study sought to evaluate the clinical and sociodemographic profile of patients with epilepsy (PWE) attended at a regional reference psychiatric emergency unit. A retrospective, cross-sectional, and descriptive observational study was conducted utilizing a patient record
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Oligoepilepsy and lifelong seizure susceptibility in epilepsy with generalized tonic-clonic seizures alone: Experience at an adult tertiary center Epilepsy Res. (IF 2.0) Pub Date : 2024-04-19 Javier Peña-Ceballos, Patrick B. Moloney, Ronan D. Kilbride, Hany El Naggar, Peter Widdess-Walsh, Norman Delanty
Epilepsy with generalized tonic-clonic seizures alone (GTCA) is the least studied syndrome within the idiopathic generalized epilepsy (IGE) spectrum. We characterize a large cohort of adult patients with GTCA to understand natural history and drug responsiveness. In this retrospective single-center study using our epilepsy electronic record, we evaluated clinical characteristics, seizure outcomes,
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Genotype and phenotype features and prognostic factors of neonatal-onset pyridoxine-dependent epilepsy: A systematic review Epilepsy Res. (IF 2.0) Pub Date : 2024-04-17 Chuchu Fang, Lin Yang, Feifan Xiao, Kai Yan, Wenhao Zhou
Pyridoxine-dependent epilepsy (PDE-) is a rare autosomal recessive disorder due to a deficiency of α-aminoadipic semialdehyde dehydrogenase. This study aimed to systematically explore genotypic and phenotypic features and prognostic factors of neonatal-onset PDE. A literature search covering PubMed, Elsevier, and Web of Science was conducted from January 2006 to August 2023. We identified 56 eligible
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Clinical correlates of negative health events and disparities among adults with epilepsy enrolled in a self-management clinical trial Epilepsy Res. (IF 2.0) Pub Date : 2024-04-16 Gena R. Ghearing, Maegan Tyrrell, Jessica Black, Jacqueline Krehel-Montgomery, Joy Yala, Clara Adeniyi, Farren Briggs, Martha Sajatovic
Despite advances in care, people with epilepsy experience negative health events (NHEs), such as seizures, emergency department (ED) visits and hospitalizations. This analysis using baseline data from an epilepsy self-management clinical trial targeting people from rural regions and other underserved populations assessed the relationship between demographic and clinical variables vs. NHEs. Data to
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The suppressive effect of the specific KCC2 modulator CLP290 on seizure in mice Epilepsy Res. (IF 2.0) Pub Date : 2024-04-16 Jingyi Cai, Zhuoyi Wu, Guoxiang Wang, Xiran Zhao, Xiaohan Wang, Benjamin H. Wang, Jiangning Yu, Xu Liu, Yun Wang
Epilepsy is a chronic neurological disorder characterized by episodic dysfunction of central nervous system. The most basic mechanism of epilepsy falls to the imbalance between excitation and inhibition. In adults, GABA receptor (GABAR) is the main inhibitory receptor to prevent neurons from developing hyperexcitability, while its inhibition relies on the low intracellular chloride anion concentration
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Pharmacological evaluation of E2730, a novel selective uncompetitive GAT1 inhibitor, on epileptiform activities in resected brain tissues from human focal cortical dysplasia ex vivo Epilepsy Res. (IF 2.0) Pub Date : 2024-04-16 Hiroki Kitaura, Kazuyuki Fukushima, Masafumi Fukuda, Yosuke Ito, Akiyoshi Kakita
Focal cortical dysplasia (FCD) is an important etiology of focal epilepsy in children and adults. However, only a few preclinical models sufficiently reproduce the characteristic histopathologic features of FCD. To improve the success rate of clinical trials for antiseizure medications (ASMs) in patients with FCD, more human-relevant preclinical models are needed, and epileptic foci resected from patients
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Current practice and safety measures in epilepsy monitoring units in the Gulf Cooperation Council Countries: A cross-sectional study Epilepsy Res. (IF 2.0) Pub Date : 2024-04-13 Bandar N. Aljafen, Ruwa A. Alneseyan, Mohamed H. Bahr, Taim A. Muayqil, Faisal Al-Otaibi
An increasing number of Epilepsy Monitoring Units (EMU) display various practices and safety protocols. EMU settings should meet clear, standardized safety protocols to avoid seizure adverse events (SAE). We aim to provide the foundational framework facilitating the establishment of unified evidence-based safety regulations to address the practices and safety measures implemented within the Gulf Cooperation
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Early versus late switch over of antiseizure medications from intravenous to the oral route in children with seizures: Single-blinded, randomized controlled trial (ELAIO trial) Epilepsy Res. (IF 2.0) Pub Date : 2024-04-12 Prateek Kumar Panda, Sanjot Bhardwaj, Vignesh Kaniyappan Murugan, Aman Elwadhi, Puneet Dhamija, Lokesh Tiwari, Indar Kumar Sharawat
Early switch-over of anti-seizure medications (ASMs) from intravenous to oral route may reduce the duration of hospitalization, drug acquisition costs, and behavioral upset in hospitalized children with seizures. The primary objective was to compare short-term seizure recurrence within 1 week in hospitalized children aged 1 month to 18 years with new-onset/breakthrough seizures after an early versus
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Modulation index predicts the effect of ethosuximide on developmental and epileptic encephalopathy with spike-and-wave activation in sleep Epilepsy Res. (IF 2.0) Pub Date : 2024-04-04 Takashi Shibata, Hiroki Tsuchiya, Mari Akiyama, Tomoyuki Akiyama, Katsuhiro Kobayashi
In developmental and epileptic encephalopathy with spike-and-wave activation in sleep (DEE-SWAS), the thalamocortical network is suggested to play an important role in the pathophysiology of the progression from focal epilepsy to DEE-SWAS. Ethosuximide (ESM) exerts effects by blocking T-type calcium channels in thalamic neurons. With the thalamocortical network in mind, we studied the prediction of
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Nonadherence to antiepileptic medication and associated factors among persons with epilepsy in India: A systematic review and meta-analysis Epilepsy Res. (IF 2.0) Pub Date : 2024-04-03 Aditya Pratap Singh, Vaibhav Chaudhary, Sweta Kumari, Deepali Dhir, Varsha Devi, Biplab Pal
Nonadherence to antiepileptic drugs (AEDs) is a prevalent issue in India, contributing to suboptimal seizure control, higher morbidity and mortality, increased hospitalization rates, and a substantial effect on the overall quality of life for individuals with epilepsy. This study aimed to measure the prevalence of medication adherence among individuals with epilepsy in India and to identify factors
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Development and prospective clinical validation of a convolutional neural network for automated detection and segmentation of focal cortical dysplasias Epilepsy Res. (IF 2.0) Pub Date : 2024-04-03 Vicky Chanra, Agata Chudzinska, Natalia Braniewska, Bartosz Silski, Brigitte Holst, Thomas Sauvigny, Stefan Stodieck, Sirko Pelzl, Patrick M. House
Focal cortical dysplasias (FCDs) are a leading cause of drug-resistant epilepsy. Early detection and resection of FCDs have favorable prognostic implications for postoperative seizure freedom. Despite advancements in imaging methods, FCD detection remains challenging. House et al. () introduced a convolutional neural network (CNN) for automated FCD detection and segmentation, achieving a sensitivity
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Designing next-generation subscalp devices for seizure monitoring: A systematic review and meta-analysis of established extracranial hardware Epilepsy Res. (IF 2.0) Pub Date : 2024-03-30 Sabry L. Barlatey, George Kouvas, Aleksander Sobolewski, Andreas Nowacki, Claudio Pollo, Maxime O. Baud
Implantable brain recording and stimulation devices apply to a broad spectrum of conditions, such as epilepsy, movement disorders and depression. For long-term monitoring and neuromodulation in epilepsy patients, future extracranial subscalp implants may offer a promising, less-invasive alternative to intracranial neurotechnologies. To inform the design and assess the safety profile of such next-generation
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Alterations in HCN1 expression and distribution during epileptogenesis in rats Epilepsy Res. (IF 2.0) Pub Date : 2024-03-24 Ke Zhao, Yinchao Li, Huanling Lai, Ruili Niu, Huifeng Li, Shipei He, Zhengwei Su, Yue Gui, Lijie Ren, Xiaofeng Yang, Liemin Zhou
The hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN1) is predominantly located in key regions associated with epilepsy, such as the neocortex and hippocampus. Under normal physiological conditions, HCN1 plays a crucial role in the excitatory and inhibitory regulation of neuronal networks. In temporal lobe epilepsy, the expression of HCN1 is decreased in the hippocampi of both
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Re-exploring the relationship between skull thickness and alpha asymmetry: A CT/MR imaging correlation study Epilepsy Res. (IF 2.0) Pub Date : 2024-03-21 T.A. Sangeeth, A. Asranna, R. Kenchaiah, R.C. Mundlamuri, LG Viswanathan, K. Kulanthaivelu, Thennarasu Kandavel, S. Sinha
The alpha rhythm has been a subject of research for the past few decades. Right-left alpha amplitude asymmetry is a common phenomenon. Several explanations have been proposed to explain this asymmetry, including differences in skull thickness. Our research aims to improve our understanding of the relationship between alpha asymmetry and skull thickness as measured by CT/MRI images. We analyzed EEGs