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Clinicopathologic Analysis of HPV-Related Primary Squamous Cell Carcinoma of the Thyroid. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-09-12 Chen Zhou,Feng Li,Gang Chen,Chao Wu,Jin-Gui Jiang,Jing-Ling Duan
OBJECT This study aims to explore the clinical and pathologic characteristics of HPV-related primary thyroid squamous cell carcinoma (PSCCT), a rare tumor classified by WHO-5 as a subtype of anaplastic thyroid carcinoma (ATC). METHODS Clinical data, histomorphology, immunohistochemistry, HPV detection, and B-raf gene point mutations of 3 PSCCT cases were analyzed. Subsequent follow-up was conducted
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Higher Expression of Talin-1 is Associated With Less Aggressive Tumor Behavior in Pancreatic Cancer. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-09-11 Samira Ahmadi Jazi,Fatemeh Tajik,Fereshteh Rezagholizadeh,Seyed Reza Taha,Mahdieh Shariat Zadeh,Behnaz Bouzari,Zahra Madjd
Talin-1 is one of the major scaffold proteins in focal adhesions playing a vital role in cell migration, metastasis, and cancer progression. Although studies regarding the importance of Talin-1 in cancer have rapidly developed, its prognostic and diagnostic value still remain unsatisfying in pancreatic cancer (PC). Therefore, the present study aims to investigate the expression, clinical significance
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Impact of Long-term Storage in 4% Formaldehyde on Immunophenotypic Markers in Glutaraldehyde-treated Bovine Pericardium. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-08-22 Douglas M Gewehr,Pedro E P Carvalho,Fernanda P Izar,Alexandre G Haddad,Victor D Falkenbach Tenius,Allan F Giovanini,Luiz F Kubrusly
Bovine pericardium (BP) is widely used as a biomaterial for tissue engineering. Glutaraldehyde and formaldehyde are commonly employed in the reticulation processes to enhance the material's resistance and preservation. In this study, we assessed the impact of long-term storage in 4% formaldehyde on the quantitative expression of immunophenotypic markers in glutaraldehyde-treated BP. Histologic and
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Brightfield Multiplex Immunohistochemistry Assay for PD-L1 Evaluation in Challenging Melanoma Samples. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-08-21 Filippo Ugolini,Luca Tinunin,Filippo Nozzoli,Sara Simi,Dario Di Gangi,Gianna Baroni,Pietro Antonini,Anna Szumera-Ciećkiewicz,Daniela Massi
Targeting the PD1/PD-L1 immune checkpoint pathway has rapidly become a therapeutic strategy for melanoma patients. Indeed, the quantification of PD-L1 expression by immunohistochemistry (IHC) in melanoma samples is already required, in some contexts, to allow access to anti-PD-1/PD-L1 immunotherapy. Despite a rising demand for PD-L1 testing, paralleling increasing cumulative experience in its assessment
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Utility of SATB2 and MOC-31 Immunostains to Distinguish Between Poorly Differentiated Rectal Adenocarcinoma and Anal Squamous Cell Carcinoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-08-15 Jiayun M Fang,Naziheh Assarzadegan,Jerome Cheng,Laura Lamps
OBJECTIVES Colorectal adenocarcinoma and squamous cell carcinoma (SCC) can arise in the anorectum and present a significant diagnostic challenge when poorly differentiated. Accurate diagnosis can significantly influence management, as the treatments for these conditions involve distinct neoadjuvant chemoradiotherapy regimens. MOC-31 and SATB2 have been utilized as specific markers of glandular differentiation
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Universal Lynch Syndrome Screening in Colorectal Cancer: A 5-Year Experience of a Portuguese Pathology Department. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-08-06 Vânia Almeida,Luis Veloso,Paulo Teixeira,Augusta Cipriano
Lynch syndrome (LS) is a prevalent genetic condition associated with colorectal cancer (CRC). Accurate identification of LS patients is challenging, and a universal tumor screening approach has been recommended. We present the methodology and results of universal LS screening in our hospital's Pathology Department. This retrospective study analyzed CRC tumors from a 5-year period (2017-2021). Immunohistochemistry
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Use of SATB2 and CDX2 Immunohistochemistry to Characterize and Diagnose Colorectal Cancer. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-07-30 Shunsuke Kato,Akira Koshino,Jerzy Lasota,Masayuki Komura,Chengbo Wang,Masahide Ebi,Naotaka Ogasawara,Kazuhisa Kojima,Toyonori Tsuzuki,Kenji Kasai,Satoru Takahashi,Markku Miettinen,Kunio Kasugai,Shingo Inaguma
SATB2 has been reported to be highly specific for lower gastrointestinal tract tumors. On the basis of its ileum-colon conversion effects, which involve the activation of colonic genes in cooperation with CDX2 and HNF4A, we hypothesized that SATB2 and CDX2 might define the characteristics of colorectal cancers (CRCs). In the present study, the clinicopathologic and immunohistochemical characteristics
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Peripheral Blood and Bone Marrow Findings in Treatment-Naive Patients With Cytopenia(s)/Myeloid Neoplasms Harboring Both a Germline and a Somatic DDX41 Mutation. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-07-24 Frido K Bruehl,Ismail Elbaz Younes,David S Bosler,Katalin Kelemen,Liuyan Jiang,Kaaren K Reichard
DDX41 -associated cytopenia(s)/myeloid neoplasms ( DDX41 -C/MNs) are an emerging pathologic entity. We examined the hematopathologic findings in DDX41 -C/MNs with both a germline and somatic DDX41 mutation ( DDX41 -C/MNs-GS). We reviewed the peripheral blood and bone marrow (BM) findings from treatment-naive patients with DDX41 -C/MNs-GS. Thirty cases were identified: 10% (3/30) were classified as
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Merkel Cell Carcinoma With Extensive Bone Marrow Metastasis and Peripheral Blood Involvement: A Case Report With Immunohistochemical and Mutational Studies. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-07-11 Benjamin Highland,William Patrick Morrow,Karen Arispe,Michael Beaty,Danielle Maracaja
Merkel cell carcinoma (MCC) is a rare, highly aggressive skin cancer of neuroendocrine origin that is typically associated with either the presence of Merkel cell polyomavirus or chronic exposure to ultraviolet (UV) light. We report a case of relapsed MCC that presented with new symptoms of fatigue, back pain, and myeloid left shift identified during scheduled follow-up. The patient was found to have
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Unusual PEComa With PRCC :: TFE3 Fusion Mimicking Sinonasal Tract Melanoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-07-09 Jerzy Lasota,Lester D R Thompson,Małgorzata Chłopek,Artur Kowalik,Markku Miettinen
BACKGROUND We report a nasal cavity unusual perivascular epithelioid cell tumor (PEComa) mimicking mucosal melanoma. METHODS Immunohistochemistry was performed using BenchMark Ultra and panel of antibodies. The Ion Torrent platform and Ion AmpliSeq cancer hotspot panel were utilized for DNA genotyping. Target-specific RNA libraries for the detection of fusion transcripts were constructed using Archer
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Diagnostic Value of Combined BCOR, Cyclin D1, and CD10 in Differentiating Endometrial Stromal Sarcoma From Other Uterine Spindle Cell Lesions. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-07-04 Mariam B Abouelkhair,Marwa M Shakweer,Malames M Faisal,Magda H Nasreldin,Laila M Farid
Uterine spindle cell lesions share a dilemmatic overlapped features that needed to be addressed by the pathologist to reach a conclusive accurate diagnosis for its prognostic value and different management decisions. Usage of combined IHC panel can be an aiding guiding tool in this context. The aim of this study is to evaluate the diagnostic value of combined BCOR, Cyclin D1, and CD10 IHC panel in
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Utility of PD-1, PD-L1, and IDO-1 Stains in Ocular Extranodal Marginal Zone Lymphoma (MZL) and Diffuse Large B-cell Lymphoma (DLBCL). Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-06-20 Alexander Craig,Ekin Güney,Melike Pekmezci,Michele Bloomer,Zoltan Laszik,Robert S Ohgami,Angus Toland,Hannes Vogel,Taylor Forns,Endi Wang,James Rubenstein,Kwun Wah Wen
Extranodal marginal zone lymphoma (EMZL) is the most common subtype of ocular lymphomas. Diffuse large B-cell lymphoma (DLBCL) and EMZL with large-cell transformation present diagnostic challenges. Radiotherapy is the standard treatment for ocular lymphomas, but complications and relapse are common. Diagnostic utility in challenging cases, as well as treatment options using immune checkpoint inhibitors
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Expression and Clinical Significance of Ki-67, CD10, BCL6, MUM1, c-MYC, and EBV in Diffuse Large B Cell Lymphoma Patients. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-06-14 Alireza Sadeghipour,Seyed Reza Taha,Mahdieh Shariat Zadeh,Farid Kosari,Pegah Babaheidarian,Fahimeh Fattahi,Navid Abdi,Fatemeh Tajik
INTRODUCTION Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) in adults. Although studies regarding the association between the expression of Ki-67, CD10, BCL6, and MUM1 proteins, as well as c-MYC amplification and EBV status with clinicopathologic characteristics have rapidly progressed, their co-expression and prognostic role remain unsatisfactory. Therefore
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Clinicopathological Impact of FOXM1 and MMP-9 Immunohistochemical Expression in Different Grades of Intracranial Meningioma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-06-12 Hanaa M Ibrahim,Aziza E Abdelrahman,Amira Elwan,Shimaa A Gharieb,Mohammed Refaat,Wael Elmesallamy,Amira A Salem
OBJECTIVES To find predictive biomarkers for recurrence and progression of meningioma. BACKGROUND Despite great advances in meningioma treatment, the prognosis remained unfavorable due to the high recurrence rate. METHODS In this study, we evaluated the immunohistochemical expression of FOXM1, MMP-9, and Ki67 in 50 cases of intracranial meningioma to detect its potential role in meningioma progression
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The Expression of PRAME as an Aid for Diagnosis and Evaluation of Histologic Margins of Intraepidermal Cutaneous Melanoma in Xeroderma Pigmentosum Patients. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-06-11 Leonardo Ávila Ferreira,Esther Hae Ji Kim,Rafael Fantelli Stelini,Paulo Eduardo Neves Ferreira Velho,Aparecida Machado de Moraes,Thais Buffo,Maria Letícia Cintra
Xeroderma Pigmentosum (XP) is a genetic disorder characterized by photosensitivity, dyschromia, and high risk of skin cancer. From a clinical and histologic view, it can be difficult to diagnose cutaneous melanoma (CM) in XP patients and to define its resection margins. We aimed to study the role of PRAME (PReferentially Expressed Antigen in MElanoma) in differentiating intraepidermal CM from superficial
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PD-L1 and PD-L2 Expression in Different Tumor Stages and Types of Malignant Salivary Gland Neoplasms: A Single-center Experience. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-06-07 Busra Yaprak Bayrak,Isa Cam,Aziz H Civriz,Esra B Tunce,Bekir C Ozcan,Yigit K Akyol,Hasan M Deger,Cigdem Vural,Murat Ozturk
There is a limited amount of data on the role of programmed cell death ligand (PD-L) -1 and PD-L2 in salivary gland carcinomas. We aimed to evaluate the prognostic value of PD-L1 and PD-L2 expressions, which are closely related to immune mechanisms, with respect to salivary gland tumor types and stages. Data from patients with salivary gland masses surgically removed between 2006 and 2021, diagnosed
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Different Frequency and Clinical Role for MTAP Loss in Pleural and Peritoneal Mesothelioma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-28 Ben Davidson,Arild Holth,Charlotte Hummel,Kjersti Flatmark,Annette Torgunrud
The objective of this study was to analyze the expression and prognostic role of methylthioadenosine phosphorylase (MTAP) in mesothelioma. MTAP protein expression by immunohistochemistry was analyzed in 113 mesotheliomas (60 pleural and 53 peritoneal), consisting of 36 effusions and 77 surgical specimens. MTAP expression was fully lost in 38 tumors and partially lost in 8 tumors. Loss of expression
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The BRAF V600E Mutation and Clinicopathological Changes Among Patients With Hashimoto Thyroiditis, Papillary Thyroid Carcinoma With Hashimoto Thyroiditis, and Nodular Goiter. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-22 Juqing Deng,Lu Yu,Shibi Luo,Zhongcun Yang,Jie Liu,Liqiong Liao
The study aimed to investigate the BRAF V600E mutation and clinicopathological changes among patients with Hashimoto thyroiditis (HT), papillary thyroid carcinoma (PTC) with Hashimoto thyroiditis (HT), or nodular goiter (NG). A total of 87 patients with the BRAF V600E mutation who were diagnosed with HT (including with hyperplasia dysplasia), PTC with HT, and PTC with NG were enrolled. Clinical data
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Performance Analysis of Leica Biosystems Monoclonal Antibody Programmed Cell Death Ligand 1 Clone 73-10 on Breast, Colorectal, and Hepatocellular Carcinomas. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-10 Konstantin Shilo,Tiansheng Shen,Scott Hammond,Anil V Parwani,Zaibo Li,Shubham Dayal,Joseph Chiweshe,Fangru Lian
Programmed cell death receptor 1/Programmed cell death ligand 1 (PD-L1) checkpoint pathway is responsible for the control of immune cell responses. Immunotherapy using checkpoint inhibitors, such as anti-PD-L1 therapy, aids disease management and potentiates clinical outcomes. This study aimed to analyze the performance of the Leica Biosystems (LBS) USA FDA class I in vitro diagnostic monoclonal antibody
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Immunohistochemical Approach to Mismatch Repair Deficiency in Pediatric High-Grade Glioma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-09 Mehmet Arda Inan,Betul Ogut,Meral Toker,Aylar Poyraz
Knowledge of the molecular pathways of pediatric high-grade gliomas is increasing. Gliomas with mismatch repair deficiency do not currently comprise a distinct group, but data on this topic have been accumulating in recent publications. Immunohistochemistry can effectively determine mismatch repair status, indirectly suggesting the microsatellite instability of the tumor. This study aimed to determine
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A Cerebellar Tumor-to-Tumor Metastasis in a Patient With Von Hippel-Lindau Disease. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-07 Tengfei Wang,Lina Liu,Debby Rampisela,Xiuhua Dong,Kristin Alexndria Keith,Ethan A Benardete,Frank Y Shan
Tumor-to-tumor metastasis in the central nerve system is uncommon in our routine practice. Most reports include metastatic breast cancer into meningioma. Here we report a metastatic clear cell renal cell carcinoma (ccRCC) into a cerebellar hemangioblastoma in a patient with von Hippel-Lindau (VHL) disease. Imaging cannot distinguish metastatic ccRCC from primary cerebellar hemangioblastoma. Immuno-molecular
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Double Chromogen-based Immunohistochemical Staining: An Efficient Approach for Utilizing Long-term Formalin-fixed Tissue in Biobanks. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-07 Dhiraj Maskey,Julia Stevens,Caine C Smith,Mario Novelli,Greg T Sutherland
The New South Wales Brain Tissue Resource Centre is a human brain bank that provides top-quality brain tissue for cutting-edge neuroscience research spanning various conditions from alcohol use disorder to neurodegenerative diseases. However, the conventional practice of preserving brain tissue in formalin poses challenges for immunofluorescent staining primarily due to the formalin's tendency, over
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Clonotypic VDJ Rearrangements in Mixed Phenotype Acute Leukemia can be Successfully Utilized to Track Minimal Residual Disease. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-02 Marah Hennawi,Faatima Quadeer,Nagehan Pakasticali,Sami Osman,Hammad Tashkandi,Mohammad Omar Hussaini
INTRODUCTION Multiplex polymerase chain reaction (PCR) and next-generation sequencing (NGS) can both be used to identify a neoplastic clonotype by targeting CDR3 and assessing rearrangements in IgH, IgK, IgL, TCR-β, and TCR-gamma loci. The clonotypic sequence can be robustly used to track minimal residual disease (MRD). The ability to track MRD by NGS in mixed phenotype acute leukemia (MPAL) is unknown
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Expression and Prognosis of Differential Gene Troponin T1 Between Right and Left Colon Cancers. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-05-02 Yue Wu,Yijun Zhang,Fanfan Xu,Ziyan Zhang,Yinzhong Wang
Colorectal cancer (CRC) is one of the most common digestive tract tumors in humans. At present, many scholars believe that the primary site of the tumor has a direct and profound impact on its curative effect. There are significant differences in the expression of many genes, tumor microenvironment, and prognosis between the left and right colon. However, there is a lack of detailed studies on whether
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Interleukin-6-Positive Immune Cells as a Possible New Immunologic Marker Associated With the Colorectal Cancer Prognosis. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-04-22 Maya Gulubova,Dimitur Chonov,Elina Aleksandrova,Koni Ivanova,M Magdalena Ignatova,Tatyana Vlaykova
Chronic inflammation creates tumor microenvironment (TME) that facilitates colorectal cancer (CRC) cell proliferation, migration, metastasis, and tumor progression. Interleukin-6 (IL-6) is a proinflammatory cytokine with a pleiotropic effect on CRC development. We aimed to evaluate IL-6 expression in tumor cells and in immune cells in TME, to assess the serum level and IL6 -174 G/C genotype distribution
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Reliable Method for Estimating Nerve Fiber Density in Epidermis Using Routine Histopathologic Tissue Preparation: A Promising Diagnostic Tool for Small Fiber Neuropathy. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-04-22 Oskar Aspegren,Kaveh Pourhamidi
Practical yet reliable diagnostic tools for small-fiber neuropathy are needed. We aimed to establish a histopathologic protocol for estimating intraepidermal nerve fiber density (eIENFD) on formalin-fixed, paraffin-embedded tissue (FFPE), evaluate its reliability through intraobserver and interobserver analyses, and provide normative reference values for clinical use. Sixty-eight healthy participants
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Human Epidermal Growth Factor Receptor 2 Overexpression/Amplification in Primary Ovarian Endometrioid Carcinoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-04-18 Chau M Bui,Aviv Oren,Bonnie Balzer,Horacio Maluf,Fabiola Medeiros
Human epidermal growth factor receptor 2 (HER2) expression has become increasingly helpful in predicting responses to anti-HER2 agents in gynecological cancers. This study retrospectively analyzed HER2 expression in 48 primary ovarian endometrioid carcinomas. HER2 immunohistochemistry was performed using the Ventana platform (Clone 4B5 monoclonal predilute) following the manufacturer's protocol. HER2
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Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-04-12 Shahroo Etemad-Moghadam,Hadiseh Mohammadpour,Amirnader Emami Razavi,Mojgan Alaeddini
The pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) family has been found to have both tumor-suppressor and oncogenic properties across various types and locations of cancer. Given that PHLPP has not been previously studied in oral squamous cell carcinoma (SCC), we conducted an assessment of the expression of both its isoforms in oral SCC tissues and cell lines and compared
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Expression of TGF-β1 in Gastrointestinal Stromal Tumor (GIST) and the Occurrence of Frequent Desmoplasia. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-04-08 Kunio Mochizuki,Naoki Oishi,Ippei Tahara,Tomohiro Inoue,Tetsuo Kondo
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms with variable behavior characterized by differentiation toward the interstitial cells of Cajal occurring anywhere in the gastrointestinal stromal tract. Frequently, GISTs have fibrous stroma within tumor cell proliferation areas, which is unlike other types of malignant tumors. If this desmoplasia is active, there is a possibility that
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Correlation Between miR-497-5p Expression With Clinicopathological Characteristics and Prognosis in Patients With Breast Cancer. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-03-18 Zhiying Zhang,Ying Zhou,Shujing Liang
Breast cancer (BC) comprises multiple biological and histologic properties. MicroRNAs show key functions in cancer prognosis. This paper explored the relationship between miR-497-5p with clinicopathological characteristics and prognosis in BC. Cancer tissues and normal adjacent tissues (NATs) were collected from 140 included patients with BC. The clinical baseline data, including age, tumor size, pathologic
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Assessment of MUC5AC and MUC2 Immunoexpression in Glandular Odontogenic Cysts, Dentigerous Cysts, and Mucoepidermoid Carcinomas. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-03-14 Kiran Jot,Vivek Nayyar,Varun Surya,Aanchal Kakkar,Shraddhanjali Satapathy,Ajoy Roychoudhury,Deepika Mishra
Glandular odontogenic cysts (GOCs) and dentigerous cysts may show mucous metaplasia. Central mucoepidermoid carcinoma is very rare and mostly associated with dental cysts. It is hypothesized that odontogenic cysts showing mucus differentiation in their lining, have a propensity to transform into MEC. The present study is the first attempt to explore the relationship between odontogenic cysts [GOCs
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Expression of Early Growth Response 3 in Skin Cancers. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-03-14 Kai-Yi Zhou,Li-Jia Deng,Si-Yu Luo,Qin-Xiao Wang,Sheng Fang
OBJECTIVE To assess the expression of early growth response 3 (EGR3) in normal skin and different types of skin tumors: cutaneous squamous cell carcinoma (cSCC), basal cell carcinoma (BCC), melanoma (MM), and cutaneous adnexal tumors containing sebaceous carcinoma (SC), trichoepithelioma (TE) and clear cell hidradenoma (CCH). BACKGROUND EGR3, expressed in multiple organs, including skin, plays an important
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Ki-67 Testing in Breast Cancer: Assessing Variability With Scoring Methods and Specimen Types and the Potential Subsequent Impact on Therapy Eligibility. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-03-07 Therese Bocklage,Virgilius Cornea,Caylin Hickey,Justin Miller,Jessica Moss,Mara Chambers,S Emily Bachert
Abemaciclib was originally FDA approved for patients with ER-positive/HER2-negative breast cancer with Ki-67 expression ≥20%. However, there were no guidelines provided on which specimen to test or which scoring method to use. We performed a comprehensive study evaluating the variation in Ki-67 expression in breast specimens from 50 consecutive patients who could have been eligible for abemaciclib
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Characterization of BCL-X L , MCL-1, and BAX Protein Expression in Response to Neoadjuvant Chemotherapy in Breast Cancer. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-03-01 Tareq Saleh,Sofian Al Shboul,Heyam Awad,Mohammed El-Sadoni,Ahmad Alhesa,Elham Alsharaiah,Nisreen Abu Shahin,Moureq R Alotaibi,AbdelKader Battah,Bilal Azab
The use of chemotherapy has improved the overall treatment of breast cancer, which is frequently administered in the form of neoadjuvant chemotherapy (NAC). Apoptosis is an established cell stress response to NAC in preclinical models; however, there is limited understanding of its role in clinical cancer, specifically, its contribution to favorable pathologic responses in breast cancer therapy. Here
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Diminution of Primary Cilia in the Stromal Cells at the Tumor-stromal Interface Correlates With an Aggressive Tumor Biology in the Urothelial Carcinoma of the Urinary Bladder. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-02-20 Vamsi K Kapaganti,Suvendu Purkait,Prasant Nayak,Dipanwita Biswas,Rasheeda Mohamedali,Amit K Adhya,Suvradeep Mitra
BACKGROUND AND AIMS Primary cilia (PC) are cellular organelles that regulate the cellular homeostasis. They are the seats of many oncogenic pathways and indirectly regulate the epithelial-mesenchymal transition (EMT) and extracellular matrix, both critical for the tumor microenvironment (TME). Though there are a few studies highlighting the alteration of PC in the tumor cells of various malignancies
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Programmed Cell Death Ligand 1 Expression in CD163 + Tumor-associated Macrophages in Cancer Gland Rupture Microenvironment. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-02-05 Yilmaz Baş,Bayram Yilmaz,Serhat Furkan Acar,İbrahim Karadağ
In this study, we aimed to examine the relationship among cancer gland rupture microenvironment, programmed cell death ligand 1 (PD-L1) expression in CD163 + tumor-associated macrophages (TAMs), and prognosis in colon adenocarcinoma. A total of 122 patients were diagnosed with colon adenocarcinoma between 2010 and 2019. PD-L1 + (clone 22C3) "macrophage scores" in the microenvironment of cancer gland
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Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-01-25 Razia Aamir,Fozia Rauf,Fatima Iqbal,Sarah Yousuf,Asif Rehman,Ahmareen K Sheikh,Sardar Muhammad
BACKGROUND Increased epidermal growth factor receptor (EGFR) expression has been implicated in several tumors and is associated with increased tumor advancement as well as a potential drug target. The objective of the study was to compare the immunohistochemical expression of EGFR in oral squamous cell carcinoma (OSCC) with oral potentially malignant disorders (OPMDs) and their demographic and pathologic
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Immunohistochemistry: The Importance of Precision Ontology to Precision Oncology. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-01-22 Emina E Torlakovic,Carol C Cheung
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The Role of Galectin3, Tubulinβ, and Maspin in Promoting Tumor Budding in Colorectal Carcinoma and Their Clinical Implications. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2024-01-22 Noha Elkady,Dina M Allam
Colorectal cancer (CRC) is a leading cause of death worldwide. Despite the advances in surgical and therapeutic management, tumor metastases and poor prognosis are still major problems. Tumor budding is a relevant prognostic factor in CRC, and it can predict tumor metastasis. Galectin3 is responsible for the development and progression of many cancers through the regulation of cell-cell/cell-matrix
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Analysis of Histomorphologic/Molecular Association and Immune Checkpoint Regulators in Epithelioid Glioblastoma and Pleomorphic Xanthoastrocytoma: Are These Tumors Potential Candidates for Immune Checkpoint Blockade? Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-30 Swati Mahajan,Jyotsna Singh,Iman Dandapath,Prerana Jha,Sujata Chaturvedi,Arvind Ahuja,Minakshi Bhardwaj,Ravindra Saran,Ajay Garg,Mehar C Sharma,Niveditha Manjunath,Ashish Suri,Chitra Sarkar,Vaishali Suri
Accurate diagnosis of Epithelioid glioblastoma (eGB) and pleomorphic xanthoastrocytoma (PXA) is sometimes challenging owing to overlapping histologic and genetic features. There are limited reports on the immune profile of these tumors. In this study, we assessed 21 PXA [15 PXA Grade 2 (PXAG2); 6 PXA Grade 3 (PXAG3)] and 14 eGB for their histopathological and molecular association. Further, their immune
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Immunohistochemical Expression of CK14 and Bcl-2 in Odontogenic Keratocyst and Its Variants. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-25 Reshma Poothakulath Krishnan,Deepak Pandiar,Sandra Sagar
Odontogenic keratocysts (OKCs) are aggressive cystic jaw lesions with a high epithelial turnover rate and increased propensity for recurrence. Sometimes, the characteristic histopathological features of OKCs are either completely lost or seen focally due to previous marsupialization or inflammation. This research aimed to determine whether specific patterns of CK14 and Bcl-2 staining could assist in
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Immunohistochemical Expression of Immune Checkpoints; CTLA-4, LAG3, and TIM-3 in Cancer Cells and Tumor-infiltrating Lymphocytes (TILs) in Colorectal Carcinoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-18 Doaa I Abdelrahman,Ibtesam Elhasadi,Amal Anbaig,Adel Bakry,Doaa Mandour,Tamer Wasefy,Ahmed M Yehia,Mohammed Alorini,Amany M Shalaby,Amar Ibrahim Omer Yahia,Mohamed A Alabiad
BACKGROUND Colorectal cancer is considered the third most prevalent cancer in both sexes. Immune checkpoint receptors that regulate T-cell response, stimulation, and development include lymphocyte activating gene 3 (LAG-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), and T-cell immunoglobulin and mucin domain 3 (Tim-3). In addition, they are crucial for the advancement of cancer and tumor
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Immunohistochemistry Detection of Histone H3 K27M Mutation in Human Glioma Tissue. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-11 Rohinton S Tarapore,Shehla Arain,Elizabeth Blaine,Adam Hsiung,Allen S Melemed,Joshua E Allen
The presence of the histone 3 (H3) K27M mutation in diffuse midline glioma has implications for diagnosis, prognosis, and treatment, making rapid and accurate H3 K27M characterization vital for optimal treatment. This study evaluated an immunohistochemical assay using a commercially available monoclonal anti-H3 K27M in human central nervous system tumors. H3 K27M-positive glioma specimens were obtained
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Rapid Immunohistochemistry Based on Ultrasonic Thermal Steam Heating for Improvement of Intraoperative Diagnosis. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-11 Guangyin Yu,Lili Tao,Mengying Liao,ChuQiang Huang,Cuimin Chen,Xiaomin Yin
OBJECTIVES To evaluate the role of rapid immunohistochemistry (RIHC) based on ultrasonic thermal steam heating in improving diagnostic accuracy of intraoperative frozen section diagnosis and to recommend RIHC antibody panels for pathologic differential diagnosis. MATERIALS AND METHODS RIHC based on ultrasonic thermal steam heating was tested for intraoperative frozen diagnosis with difficulty in diagnosis
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Immunohistochemical Comparison of Ki-67 and MCM-3 in Odontogenic Cysts: An Observational Study. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-08 Ridhi Bhola,Anjali Narwal,Mala Kamboj,Anju Devi
Odontogenic cysts are a diverse group of pathologic entities with different proliferation potential, leading to variations in their biological behavior. One of the most cited proliferation markers used in diagnostic histopathology is Ki-67. Another group of proteins recently investigated is minichromosome maintenance (MCM-3) and its expression has been evaluated in several odontogenic lesions but the
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Diagnostic Value of CD34 and CD117 Immunohistochemistry and Megakaryocyte Morphology in Myelodysplastic Syndromes: A Retrospective Case-control Study. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-12-06 Ying Zhang,Wenhua Li,Yuanchu Liang,Youli Liu,Wenbin Dai
This study evaluated the diagnostic value of CD34 and CD117 immunohistochemistry(IHC) and megakaryocyte morphology in Myelodysplastic syndromes (MDS). In this study, CD34-positive individual cells (Type I) and small clusters (Type II) were observed in most cases (91.2%). Type II CD34-positive was seen in 24 (49%) MDS cases, and positive percentage was higher than in acute myelogenous leukemia (AML)
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PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A Clinicopathologic, Prognostic, and Immunohistochemical Study. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-11-20 Ola A Harb,Mariem A Elfeky,Mohamed Ali Alabiad,Rehab Hemeda,Ahmed S Allam,Amr T El Hawary,Mohammed Elbaz,Ahmed L Sharaf,Loay M Gertallah,Ahmed Mesbah Abdelaziz,Amany Mohamed Shalaby,Mohammed Alorini,Amar Ibrahim Omer Yahia,Mohamed Negm
BACKGROUND It will be important to understand the molecular pathways of gastric cancer (GC) occurrence and progression, thus detecting predictive and prognostic biomarkers of GC. Pyrroline-5-carboxylate reductase 1 (PYCR1) was upregulated in many cancers, suggesting its possible roles in carcinogenesis and tumor metastases. Barrier-of-autointegration factor 1 (BANF1) is a protein family that plays
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Mast Cell Concentrations in Pancreatic Disease Processes. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-11-20 Lindsey Wynn,Victoria Hodges,Sheila Criswell
Mast cells enumeration has been performed using various histologic staining techniques with the goal of elucidating the influence mast cells exert on pathologic processes. In this study, 77 human pancreatic tissues evidencing morphologically normal pancreas, benign fibrotic changes, endocrine tumors, and adenocarcinoma were evaluated using Wright stain and immunohistochemistry markers for tryptase
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Immunodetection of NUT Protein: Implementation, Indications, and Results in a Tertiary Reference Center. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-11-16 Hussain Noorwali,Odile Casiraghi,Marion Classe,Julien Adam,Carine Ngo,Maria-Rosa Ghigna,Christina Kanaan,Pierre Khneisser,Mohamed-Amine Bani,Sophie Cotteret,Jean-Yves Scoazec
The immunodetection of NUT protein is a reliable tool to identify NUT carcinoma, a rare and still underdiagnosed tumor entity. The technique was implemented in 2017 in our department, a tertiary reference center with a large recruitment in all tumor types, including head and neck and thoracic tumors. We evaluated its use over a 6-year period (2017-2022) to (a) describe the indications for the technique
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Implementation of Digital Image Analysis in Assessment of Ki67 Index in Breast Cancer. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-11-06 Rachel K Vanderschelden,Jacob A Jerome,Daniel Gonzalez,Lindsey Seigh,Gloria J Carter,Beth Z Clark,Esther Elishaev,Jeffrey Louis Fine,Lakshmi Harinath,Mirka W Jones,Tatiana M Villatoro,Thing Rinda Soong,Jing Yu,Chengquan Zhao,Doug Hartman,Rohit Bhargava
The clinical utility of the proliferation marker Ki67 in breast cancer treatment and prognosis is an active area of research. Studies have suggested that differences in pre-analytic and analytic factors contribute to low analytical validity of the assay, with scoring methods accounting for a large proportion of this variability. Use of standard scoring methods is limited, in part due to the time intensive
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Prognostic Value of Differential Expression of Polymerase Eta Gene in Nonresponding Patients With Diffuse Large B-cell Lymphoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-23 Aditi Sharma,Ashim Das,Amanjit Bal,Radhika Srinivasan,Pankaj Malhotra,Gaurav Prakash,Rajendar Kumar
Diffuse large B-cell lymphoma (DLBCL) represents the most common subtype of non-Hodgkins lymphoma. After the introduction of rituximab therapy like rituximab, cyclophosphamide, doxorubicin vincristine, prednisolone, there has been considerable improvement in the 5-year overall survival in this group of patients, but the nonresponding patients are a challenge to the clinician. The translesion polymerases
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Arginase-1 is More Specific Than Hepatocyte Paraffin 1 for Differentiating Hepatocellular Carcinomas With Cytoplasmic Clearing from Nonhepatocellular Clear Cell Tumors in Liver Biopsies. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-20 Brent K Larson,Deepti Dhall,Maha Guindi
Arginase-1 (Arg1) and hepatocyte paraffin antigen 1 (HepPar1) are specific and sensitive markers of hepatocellular differentiation. HepPar1 is a granular cytoplasmic immunostain that may be negative in hepatocellular carcinoma (HCC) with cytoplasmic clearing. Arg1 shows uniform cytoplasmic positivity and frequent nuclear positivity. This study was undertaken to determine the staining pattern of Arg1
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Applicability of the FDA-approved Immunohistochemical Panel for Identification of MMRd Phenotype in Uterine Endometrioid Carcinoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-20 Sumiyo Adachi,Jun-Ichiro Kimata,Kyota Hanami,Katsuyuki Adachi,Toshio Igarashi,Shan-Guang Liang,Yasuo Ishida,Takashi Fujino,Kazuto Yamazaki
Recently, the US Food and Drug Administration (FDA) approved the Ventana MMR RxDx Panel as the first immunohistochemical companion diagnostic test for identification of tumors with mismatch repair (MMR) status. The aim of this study was to investigate the accuracy of this test in comparison with polymerase chain reaction (PCR)-based microsatellite instability (MSI) analysis. We assessed the MMR/MSI
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Low UPB1 Level Correlates With Poor Prognosis in Lung Adenocarcinoma. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-20 Libin Zhang,Jun Liu,Han Wang,Zheyuan Xu,Yang Wang,Yun Chen,Hao Peng
OBJECTIVES Lung adenocarcinoma (LUAD) is a critical cancer with high mortality, worse prognosis, and crucial lymphatic metastasis. Consequently, prognostic biomarkers for LUAD are truly required. β-Ureidopropionase (UPB1) is abnormally expressed in various cancers. However, the function of UPB1 in LUAD is still ambiguous. This study aimed to explore the expression profile and prognostic significance
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Depigmentation of Melanin-containing Tissues Using Hypochlorous Acid to Enhance Hematoxylin-eosin and Immunohistochemical Staining. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-19 Lu Wang,Gangping Wang
Pathologists diagnose diseases by observing the histologic and cellular morphology microscopically. However, the high pigmentation in melanin-containing tumors can hide the tumor cell structures, making diagnosing challenging. Previously, hydrogen peroxide and potassium permanganate were utilized for melanin bleaching with several limitations. For instance, hydrogen peroxide has a weak bleaching ability
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Belgian Recommendations for Analytical Verification and Validation of Immunohistochemical Tests in Laboratories of Anatomic Pathology. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-17 Hannelien Verbeke,Donald Van Hecke,Caroline Bauraing,Anne Marie Dierick,Orphal Colleye,Ignace Dalle,Kathleen Dewachter,Yves Guiot,Raphael Lequeu,Nancy Vanderheyden,Karen Zwaenepoel,Romaric Croes
Analytical verification and validation of immunohistochemical (IHC) tests and their equipment are common practices for today's anatomic pathology laboratories. Few references or guidelines are available on how this should be performed. The study of Sciensano (the Belgian national competent authority regarding licensing of medical laboratories) performed in 2016, demonstrated a significant interlaboratory
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Comparison of Confirmed Cytology Smears and Cell Blocks for Epidermal Growth Factor Receptor Mutation Testing in Non-Small Cell Lung Cancer. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-09 Chia-Hsing Liu,Shu-Jyuan Chang,Min-Jan Tsai,Sheau-Fang Yang
INTRODUCTION Various cytologic specimens have been used to diagnose epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer (NSCLC). However, insufficient samples and lengthy DNA extraction procedures have led to inconsistent diagnostic results. To reduce manipulation losses and improve DNA extraction quality, we provide an improved procedure for DNA extraction from smear
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From Death to Life/Back to the Future: Detailed Premorbid Clinical and Family History Can Save Lives and Address the Final Diagnosis in Sudden Unexplained Deaths With Negative Autopsy. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-05 Burcu Turkgenc,Cetin L Baydar,Idris Deniz,Arzu Akcay,Mahmut Cerkez Ergoren,Sebnem Ozemrı Sag,Mustafa C Yakicier,Sehime G Temel
Sudden cardiac death is a sudden, unexpected death developed by one of the many different causes of cardiac arrest that occur within 1 hour of the onset of new symptoms. Sudden unexplained death (SUD) comprises a normal heart at postmortem examination and negative toxicological analysis. SUD often arises from cardiac genetic disease, particularly channelopathies. Channelopathies, or inherited arrhythmia
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GATA3 Expression in HPV-associated and HPV-independent Vulvar Squamous Cell Carcinomas: Patterns of Expression and Prognostic Significance. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-02 Elmira Vaziri Fard,Somaye Y Zare,Oluwole Fadare
Substantial diminution or loss of GATA3 expression is reportedly frequent in human papillomavirus-independent (HPVI), p53-mediated vulvar intraepithelial neoplasia. Herein, we study GATA3 expression in vulvar squamous cell carcinoma (VSCC) and assess its clinicopathologic significance. Eighty-six cases of VSCC diagnosed at a single institution were immunohistochemically assessed for their expression
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High TEAD4 Expression is Associated With Aggressive Clear Cell Renal Cell Carcinoma, Regardless of YAP1 Expression. Appl. Immunohistochem. Mol. Morphol. (IF 1.3) Pub Date : 2023-10-02 Min A Park,Yeong Heon Lee,Mi-Jin Gu
Yes-associated protein 1 (YAP1) and transcriptional coactivator TEA domain transcription factor 4 (TEAD4) are the main effectors of the Hippo signaling pathway. Deregulation of the Hippo signaling pathway significantly impacts tumorigenesis and tumor progression. We evaluated the mRNA expression level of YAP1 and TEAD4 using the Gene Expression Profiling Interactive Analysis database and investigated