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Delayed drug hypersensitivity reactions: How p-i transforms pharmacology into immunology. Allergol. Int. (IF 6.2) Pub Date : 2024-09-17 Werner J Pichler
Delayed drug hypersensitivity reactions (dDHRs) are iatrogenic diseases, which are mostly due to non-covalent interactions of a drug with the immune receptors HLA and/or TCR causing T-cell activation. This is also known as pharmacological interaction with immune receptors or p-i. P-i activation differs from classical antigen-driven immune reactions: a) drug binding induces structural changes in TCR-HLA
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Dupilumab-related eosinophilia in patients with severe asthma: Post-marketing surveillance in Japan. Allergol. Int. (IF 6.2) Pub Date : 2024-09-10 Makoto Nagata,Ryo Yamaguchi,Makiko Usami,Mami Orimo,Masato Ishida
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3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis. Allergol. Int. (IF 6.2) Pub Date : 2024-09-05 Shusuke Yazawa,Yuzo Suzuki,Yuko Tanaka,Koshi Yokomura,Masato Kono,Dai Hashimoto,Atsuki Fukada,Yusuke Inoue,Hideki Yasui,Hironao Hozumi,Masato Karayama,Kazuki Furuhashi,Noriyuki Enomoto,Tomoyuki Fujisawa,Naoki Inui,Takafumi Suda
BACKGROUND Hypersensitivity pneumonitis (HP) is a complex and heterogenous interstitial lung disease (ILD) that occurs in susceptible individuals due to certain inhaled antigens. Fibrotic-HP is a major underlying disease of progressive pulmonary fibrosis. Therefore, in addition to the radiological features of HP, quantitatively measuring fibrosis is important to evaluate disease severity and progression
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Quaternary ammoniums activate human dendritic cells and induce a specific T-cell response in vitro. Allergol. Int. (IF 6.2) Pub Date : 2024-09-04 Marine Peyneau,Mathilde Zeller,Virginie Paulet,Benoît Noël,Marie-Hélène Damiens,Natacha Szely,Andreas Natsch,Marc Pallardy,Sylvie Chollet-Martin,Luc de Chaisemartin,Saadia Kerdine-Römer
BACKGROUND In many countries, neuro-muscular blocking agents (NMBAs) are the first cause of perioperative anaphylaxis. Epidemiological studies identified pholcodine, a quaternary ammonium-containing opiate as one of the sensitization sources. However, NMBA anaphylaxis exists in countries where pholcodine was unavailable, prompting the hypothesis of other sensitizing molecules, most likely quaternary
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Skin reaction patterns in cholinergic urticaria. Allergol. Int. (IF 6.2) Pub Date : 2024-09-03 Ilona Shurmelova,Agata Baldyga,Eva Grekowitz,Susanne Kimeswenger,Wolfram Hoetzenecker,Marcus Maurer,Sabine Altrichter
BACKGROUND Skin reaction patterns vary across patients with cholinergic urticaria (CholU), but their definition, prevalence, and clinical significance remain ill characterized. METHODS Patients with CholU underwent pulse-controlled ergometry provocation testing to analyze skin reaction patterns and their correlation with location, onset, severity, sweating behaviour, clinical features, disease control
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Current perspective on allergen immunotherapy for food allergies Allergol. Int. (IF 6.2) Pub Date : 2024-08-30 Sakura Sato, Ken-ichi Nagakura, Noriyuki Yanagida, Motohiro Ebisawa
Food allergies are an increasing global problem and societal issue. In addition to the potential for severe allergic reactions from accidental ingestion, food allergies impose a significant burden on the quality of life, nutrition, cost of living, and social activities of both those afflicted and their caregivers. Strict avoidance of allergens and use of emergency medications to treat allergic reactions
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Aspiration of acidified milk induces milk allergy by activating alveolar macrophages in mice. Allergol. Int. (IF 6.2) Pub Date : 2024-08-28 Akiko Nakaoka,Takayasu Nomura,Atsushi Suzuki,Kazuyoshi Ozeki,Hirohito Kita,Shinji Saitoh
BACKGROUND Epidemiological studies have identified associations between gastroesophageal reflux (GER) and cow's milk allergy (CMA) in infants. However, the role of GER in the development of CMA remains poorly understood. Our primary objectives were to develop a mouse model that suggests GER as a potential pathogenic mechanism for CMA and to elucidate the immunological mechanisms that connect lung innate
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Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease. Allergol. Int. (IF 6.2) Pub Date : 2024-08-19 Mitsuhiro Akiyama,Waleed Alshehri,Sho Ishigaki,Koichi Saito,Yuko Kaneko
Human T follicular helper (Tfh) cells play a crucial role in orchestrating B cell differentiation, maturation, and immunoglobulin class switching. Recent studies have underscored the presence of Bcl-6 + Tfh cells not only in secondary lymphoid organs but also within tertiary lymphoid structures at inflammatory sites, emphasizing their pivotal role in disease pathogenesis. Furthermore, Tfh cells have
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Reducing the solubility of the major birch pollen allergen Bet v 1 by particle-loading mitigates Th2 responses. Allergol. Int. (IF 6.2) Pub Date : 2024-08-17 Amin Kraiem,Erica Pelamatti,Sophie Grosse-Kathoefer,Hilal Demir,Ute Vollmann,Caroline Ehgartner,Maria Stigler,Benjamin Punz,Litty Johnson,Nicola Hüsing,Barbara Bohle,Lorenz Aglas
BACKGROUND Solubility is a common feature of allergens. However, the causative relationship between this protein-intrinsic feature and sensitization capacity of allergens is not fully understood. This study aimed to proof the concept of solubility as a protein intrinsic feature of allergens. METHODS The soluble birch pollen allergen Bet v 1 was covalently coupled to 1 μm silica particles. IgE-binding
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Use of explainable AI on slit-lamp images of anterior surface of eyes to diagnose allergic conjunctival diseases. Allergol. Int. (IF 6.2) Pub Date : 2024-08-17 Michiko Yonehara,Yuji Nakagawa,Yuji Ayatsuka,Yuko Hara,Jun Shoji,Nobuyuki Ebihara,Takenori Inomata,Tianxiang Huang,Ken Nagino,Ken Fukuda,Tatsuma Kishimoto,Tamaki Sumi,Atsuki Fukushima,Hiroshi Fujishima,Moeko Kawai,Etsuko Takamura,Eiichi Uchio,Kenichi Namba,Ayumi Koyama,Tomoko Haruki,Shin-Ich Sasaki,Yumiko Shimizu,Dai Miyazaki
BACKGROUND Artificial intelligence (AI) is a promising new technology that has the potential of diagnosing allergic conjunctival diseases (ACDs). However, its development is slowed by the absence of a tailored image database and explainable AI models. Thus, the purpose of this study was to develop an explainable AI model that can not only diagnose ACDs but also present the basis for the diagnosis.
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In vitro cross-reactivity between hen's egg and quail's egg in children with hen's egg allergy. Allergol. Int. (IF 6.2) Pub Date : 2024-08-16 Mari Takei,Masatoshi Mitomori,Akemi Saito,Kinji Tada,Noriyuki Yanagida,Sakura Sato,Motohiro Ebisawa
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From the genesis to the present: The evolution of sublingual immunotherapy for cedar pollinosis Allergol. Int. (IF 6.2) Pub Date : 2024-07-22 Minoru Gotoh, Osamu Kaminuma, Kimihiro Okubo
In 2004, we started the initial attempt to evaluate the efficacy of SLIT for Japanese cedar pollinosis (JCP) using Japanese cedar (JC) pollen extract solution through a multicenter, placebo-controlled, double-blind comparative study. Based on its success in demonstrating the substantial efficacy of SLIT, we next conducted a larger-scale study by administering JC pollen to all JCP patients recruited
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A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation Allergol. Int. (IF 6.2) Pub Date : 2024-07-17 Zhengxia Wang, Xinyu Jia, Wei Sun, Min Wang, Qi Yuan, Tingting Xu, Yanan Liu, Zhongqi Chen, Mao Huang, Ningfei Ji, Mingshun Zhang
Allergic asthma is largely dominated by Th2 lymphocytes. Micropeptides in Th2 cells and asthma remain unmasked. Here, we aimed to demonstrate a micropeptide, T-cell regulatory micropeptide (TREMP), in Th2 cell differentiation in asthma.
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Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap Allergol. Int. (IF 6.2) Pub Date : 2024-07-16 Naoya Tanabe, Hisako Matsumoto, Chie Morimoto, Yusuke Hayashi, Ryo Sakamoto, Tsuyoshi Oguma, Tadao Nagasaki, Hironobu Sunadome, Atsuyasu Sato, Susumu Sato, Kai Ohashi, Takamitsu Tsukahara, Toyohiro Hirai
Despite clinical implications, the pathogenesis of mucus plugging in asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) remains unclear. We hypothesized that distinct airway microbiomes might affect mucus plugging differently among ACO, asthma, and COPD and among different extents of airway eosinophilic inflammation.
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Age-related differences in olfactory profiles and surgical outcomes in eosinophilic chronic rhinosinusitis Allergol. Int. (IF 6.2) Pub Date : 2024-07-14 Kosuke Akiyama, Yukako Arakawa, Yasushi Samukawa, Hiroshi Hoshikawa
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Allergen immunotherapy in asthma Allergol. Int. (IF 6.2) Pub Date : 2024-07-01 Kazuyuki Nakagome, Makoto Nagata
Allergen immunotherapy (AIT), including SCIT and SLIT, is a treatment that involves the administration of allergens to which patients with allergic diseases have been sensitized. HDM-SCIT for asthma is indicated in cases of HDM-sensitized allergic asthma with normal lung function. HDM-SCIT improves asthma symptoms and AHR, and decreases the medication dose. Importantly, AIT can improve other allergic
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Mucus plugs in severe asthma and related airway diseases. Allergol. Int. (IF 6.2) Pub Date : 2024-07-01 Koichiro Asano
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Efficacy of very-low-dose oral food challenge in children with severe hen egg allergy: A retrospective, single-center case series Allergol. Int. (IF 6.2) Pub Date : 2024-06-20 Kosei Yamashita, Maeda Mayu, Takanori Imai, Toshiyuki Takagi, Megumi Okawa, Aiko Honda, Chihiro Kunigami, Yuki Okada, Taro Kamiya
To avoid complete elimination of hen eggs (HE) from diet, we introduced a very-low-dose (VLD) oral food challenge (OFC) in patients with severe HE allergy in 2019. Herein, we investigated the efficacy of VLD HE OFC for achieving the full dose OFC.
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Skin testing and challenge in patients with immediate hypersensitivity reactions to gadolinium-based contrast agents identify safe future options Allergol. Int. (IF 6.2) Pub Date : 2024-05-30 Florian Stehlin, Rabea Y. Khoudja, Derek Lee, Jean-Francois Toupin, Ghislaine A.C. Isabwe, Michael Fein, Ibtihal Al-Otaibi, Elizabeth J. Phillips, Jason A. Trubiano, Ana-Maria Copaescu
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Efficacy of sequential fecal-marker examination for evaluating gastrointestinal inflammation in solid food protein-induced enterocolitis syndrome Allergol. Int. (IF 6.2) Pub Date : 2024-05-15 Masumi Nagata, Eisuke Inage, Hiromichi Yamada, Takahiro Kudo, Shun Toriumi, Keita Sakaguchi, Yuko Tanaka, Keisuke Jimbo, Yoshikazu Ohtsuka, Toshiaki Shimizu
Food protein-induced enterocolitis syndrome caused by solid foods (Solid-FPIES) is a non-immunoglobulin E-mediated allergic disease characterized by delayed gastrointestinal symptoms. An oral food challenge (OFC) test, although necessary, can be inconclusive in cases with mild symptoms. Moreover, limited diagnostic marker availability highlights the need for novel surrogate markers. We aimed to examine
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Efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: A randomized, double-blind, placebo-controlled phase 3 study Allergol. Int. (IF 6.2) Pub Date : 2024-05-11 Motohiro Ebisawa, Yoko Kataoka, Akio Tanaka, Mizuho Nagao, Elizabeth Laws, Eric Mortensen, Hisakatsu Nawata, Kazuhiko Arima, Daisuke Watanabe, Xin Lu, Jennifer Maloney, Ariane Dubost-Brama, Ashish Bansal, Kenji Yahata
We investigated the efficacy and safety of dupilumab in Japanese patients aged ≥6 months to <18 years old with moderate-to-severe atopic dermatitis not adequately controlled with existing therapies.
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Characteristics of food protein-induced enterocolitis syndrome with metabolic acidosis: A case–control study Allergol. Int. (IF 6.2) Pub Date : 2024-05-09 Sayaka Hamaguchi, Kiwako Yamamoto-Hanada, Erika Ogawa, Satoko Uematsu, Shima Ohnishi, Yushi Ito, Kenji Toyokuni, Miori Sato, Tatsuki Fukuie, Yukihiro Ohya, Ichiro Nomura
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Comparison of the diagnostic performance of tryptase and histamine for perioperative anaphylaxis: A multicenter prospective study Allergol. Int. (IF 6.2) Pub Date : 2024-05-09 Takashi Haraguchi, Tatsuo Horiuchi, Tomonori Takazawa, Kazuhiro Nagumo, Masaki Orihara, Shigeru Saito
Diagnosing perioperative anaphylaxis (POA) is often challenging. Although a guideline recommends measuring tryptase rather than histamine, there is little evidence for this. We aimed to examine the diagnostic performance and appropriate timing of tryptase and histamine measurements for diagnosing anaphylaxis, and the association between Hypersensitivity Clinical Scoring Scheme (HCSS) scores and elevated
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Emerging cell and molecular targets for treating mucus hypersecretion in asthma Allergol. Int. (IF 6.2) Pub Date : 2024-05-01 Ana M. Jaramillo, Eszter K. Vladar, Fernando Holguin, Burton F. Dickey, Christopher M. Evans
Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing
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Role of basal cells in nasal polyp epithelium in the pathophysiology of eosinophilic chronic rhinosinusitis (eCRS) Allergol. Int. (IF 6.2) Pub Date : 2024-04-26 Kento Kawakita, Hideaki Kouzaki, Takuya Murao, Yoshihito Kubo, Tatsuji Nishiguchi, Keigo Nakamura, Hiroyuki Arai, Koji Matsumoto, Ichiro Tojima, Shino Shimizu, Takeshi Shimizu
Basal cell hyperplasia is commonly observed in nasal polyp epithelium of eosinophilic chronic rhinosinusitis (eCRS). We examined the function and mechanisms of basal cell hyperplasia in the pathophysiology of eCRS.
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Identification of exhaled volatile organic compounds that characterize asthma phenotypes: A J-VOCSA study Allergol. Int. (IF 6.2) Pub Date : 2024-04-24 Maho Suzukawa, Ken Ohta, Masahiro Sugimoto, Nobuharu Ohshima, Nobuyuki Kobayashi, Hiroyuki Tashimo, Yasushi Tanimoto, Junko Itano, Goro Kimura, Shohei Takata, Takako Nakano, Takafumi Yamashita, Satoshi Ikegame, Kentaro Hyodo, Masahiro Abe, Kenji Chibana, Yosuke Kamide, Kazunori Sasaki, Hiroya Hashimoto
Asthma is characterized by phenotypes of different clinical, demographic, and pathological characteristics. Identifying the profile of exhaled volatile organic compounds (VOCs) in asthma phenotypes may facilitate establishing biomarkers and understanding asthma background pathogenesis. This study aimed to identify exhaled VOCs that characterize severe asthma phenotypes among patients with asthma.
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Gut microbiota of one-and-a-half-year-old food-allergic and healthy children Allergol. Int. (IF 6.2) Pub Date : 2024-04-09 Monami Hara, Hisato Suzuki, Daisuke Hayashi, Wataru Morii, Takako Nakamura, Kaori Kiyoki, Hideki Hara, Ryota Ishii, Emiko Noguchi, Hidetoshi Takada
Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age.
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Clinical characteristics and genetic HLA marker for patients with oxaliplatin-induced adverse drug reactions Allergol. Int. (IF 6.2) Pub Date : 2024-04-08 Hung-Chih Hsu, Wen-Hung Chung, Yung-Chang Lin, Tsai-Sheng Yang, John Wen-Cheng Chang, Chia-Hsun Hsieh, Shuen-Iu Hung, Chun-Wei Lu, Jen-Shi Chen, Wen-Chi Chou, Chuang-Wei Wang
Oxaliplatin is commonly used to treat gastrointestinal malignancies. However, its applications are limited due to potential adverse drug reactions (ADRs), particularly severe anaphylactic shock. There is no method to predict or prevent ADRs caused by oxaliplatin. Therefore, we aimed to investigate the genetic HLA predisposition and immune mechanism of oxaliplatin-induced ADRs.
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Eosinophilic mucus diseases Allergol. Int. (IF 6.2) Pub Date : 2024-04-08 Misaki Arima, Keisuke Ito, Tomoe Abe, Tsuyoshi Oguma, Koichiro Asano, Manali Mukherjee, Shigeharu Ueki
Eosinophilic inflammation is primarily characterized by type 2 immune responses against parasitic organisms. In the contemporary human being especially in developed countries, eosinophilic inflammation is strongly associated with allergic/sterile inflammation, and constitutes an undesired immune reaction. This situation is in stark contrast to neutrophilic inflammation, which is indispensable for the
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Blood eosinophil phenotype during treatment with mepolizumab in patients with severe eosinophilic asthma Allergol. Int. (IF 6.2) Pub Date : 2024-04-06 Chio Sakai, Masashi Matsuyama, Masayuki Nakajima, Sosuke Matsumura, Mizu Nonaka, Naoki Arai, Kenya Kuramoto, Kazufumi Yoshida, Yuko Morishima, Masafumi Muratani, Nobuyuki Hizawa
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Heterogeneity of food protein-induced enterocolitis syndrome (FPIES) Allergol. Int. (IF 6.2) Pub Date : 2024-03-27 Masayuki Akashi, Sachiko Kaburagi, Naoki Kajita, Hideaki Morita
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy with gastrointestinal symptoms such as vomiting and diarrhea. The development of international consensus guidelines for the diagnosis and management of FPIES in 2017 enabled us to compare patients worldwide, regardless of geographic variation in disease features. As a result, it has become clear that there is heterogeneity
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Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals Allergol. Int. (IF 6.2) Pub Date : 2024-03-13 Carmen Venegas Garrido, Manali Mukherjee, Sarah Svenningsen, Parameswaran Nair
Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells within the airway epithelium both in normal conditions and in response to various stimuli. Their relative proportions are correlated with specific
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Efficacy of dupilumab for airway hypersecretion and airway wall thickening in patients with moderate-to-severe asthma: A prospective, observational study Allergol. Int. (IF 6.2) Pub Date : 2024-03-12 Tomoko Tajiri, Motohiko Suzuki, Hirono Nishiyama, Yoshiyuki Ozawa, Ryota Kurokawa, Norihisa Takeda, Keima Ito, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Yuta Mori, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Kenji Izuhara, Akio Niimi
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Non-IgE-mediated food allergy: Where are we now? Allergol. Int. (IF 6.2) Pub Date : 2024-03-10 Kenji Matsumoto
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Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma Allergol. Int. (IF 6.2) Pub Date : 2024-02-24 Yusuke Hayashi, Naoya Tanabe, Hisako Matsumoto, Kaoruko Shimizu, Ryo Sakamoto, Tsuyoshi Oguma, Hironobu Sunadome, Atsuyasu Sato, Susumu Sato, Toyohiro Hirai
Associations of fractional exhaled nitric oxide (FeNO) with airway wall remodeling and mucus plugs remain to be explored in smokers and nonsmokers with asthma. Ultra-high-resolution computed tomography (U-HRCT), which allows accurate structural quantification of airways >1 mm in diameter, was used in this study to examine whether higher FeNO was associated with thicker walls of the 3rd to 6th generation
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Role of diesel exhaust particle-induced cellular senescence in the development of asthma in young and old mice Allergol. Int. (IF 6.2) Pub Date : 2024-02-12 Hyun Seung Lee, Heung-Woo Park
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Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study Allergol. Int. (IF 6.2) Pub Date : 2024-02-12 Syuji Yonekura, Yoshitaka Okamoto, Fumiya Yamaide, Taiji Nakano, Kiyomi Hirano, Urara Funakoshi, Sawako Hamasaki, Tomohisa Iinuma, Toyoyuki Hanazawa, Naoki Shimojo
This study aimed to clarify the diagnostic and predictive factors for perennial allergic rhinitis (PAR) onset in children by analyzing the results of the Chiba High-risk Birth Cohort for Allergy study, which examined newborns with a family history of allergies. Overall, 306 pregnant women were recruited. Their newborns were examined by otolaryngologists and pediatric allergists at 1, 2, and 5 years
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Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis Allergol. Int. (IF 6.2) Pub Date : 2024-02-12 Minori Sasakura, Hitoshi Urakami, Kota Tachibana, Kenta Ikeda, Ken-ichi Hasui, Yoshihiro Matsuda, Ko Sunagawa, Daisuke Ennishi, Shuta Tomida, Shin Morizane
Selective activator protein (AP)-1 inhibitors are potentially promising therapeutic agents for atopic dermatitis (AD) because AP-1 is an important regulator of skin inflammation. However, few studies have investigated the effect of topical application of AP-1 inhibitors in treating inflammatory skin disorders. Immunohistochemistry was conducted to detect phosphorylated AP-1/c-Jun expression of skin
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CLEC10A expression defines functionally distinct subsets of conventional type 2 dendritic cells (cDC2) in the mouse lung Allergol. Int. (IF 6.2) Pub Date : 2024-02-09 Fumiya Nihashi, Kazuki Furuhashi, Ryo Horiguchi, Yoshihiro Kitahara, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda
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Analysis of the relationship between comorbid obstructive sleep apnea and clinical outcomes in patients with asthma in Japan Allergol. Int. (IF 6.2) Pub Date : 2024-02-09 Hitomi Ikegami-Tanaka, Naoya Yasokawa, Koji Kurose, Shonosuke Tajima, Masaaki Abe, Shigeki Katoh, Yoshihiro Kobashi, Toru Oga
Asthma and obstructive sleep apnea (OSA) are prevalent chronic respiratory disorders, which often coexist and interact with each other. Obesity is an important risk factor shared by them. The rate of obesity is lower in Japan versus Western countries. Hence, the co-existence of asthma and OSA has not been investigated in Japan. Ninety-seven outpatients with asthma were recruited. Patients wore a portable
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Current and future perspectives on the consensus guideline for food protein-induced enterocolitis syndrome (FPIES) Allergol. Int. (IF 6.2) Pub Date : 2024-02-07 Sara Anvari, Melanie A. Ruffner, Anna Nowak-Wegrzyn
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy presenting with delayed onset of projectile vomiting in the absence of cutaneous and respiratory symptoms. The pathophysiology of FPIES remains poorly characterized. The first international consensus guidelines for FPIES were published in 2017 and provided clinicians with parameters on the diagnosis and treatment
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Effect of atopic conditions on development and recurrences of infectious keratitis Allergol. Int. (IF 6.2) Pub Date : 2024-02-02 Yutaka Omatsu, Yumiko Shimizu, Tomoko Haruki, Yoshitsugu Inoue, Dai Miyazaki
Atopic conditions are known to be associated with viral and bacterial infections. The purpose of this study was to determine the relationship between the effects of atopic conditions on the severity and recurrence of ocular infections including herpes simplex virus (HSV). This study was performed on 474 consecutive patients with infectious keratitis caused by bacteria, fungus, acanthamoeba, HSV, or
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Skin care by washing with water is not inferior to washing with a cleanser in children with atopic dermatitis in remission in summer: WASH study Allergol. Int. (IF 6.2) Pub Date : 2024-02-02 Yukiko Katoh, Osamu Natsume, Ryuhei Yasuoka, Satoshi Hayano, Eisaku Okada, Yutaka Ito, Akira Sakai, Yoko Monna, Fumitaka Takayanagi, Yusuke Inuzuka, Yuji Sakakura
Washing with water is not inferior to washing with soaps and detergents in children with atopic dermatitis (AD) in remission during the fall-winter seasons. We investigated whether this finding varies during summer based on the type of cleanser (soaps and detergents). This evaluator-blinded, pragmatic, randomized, and non-inferiority study enrolled patients with AD whose eczema was controlled following
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Three-year prognosis after low-dose oral food challenge for children with wheat allergy Allergol. Int. (IF 6.2) Pub Date : 2024-02-01 Takaaki Itonaga, Noriyuki Yanagida, Ken-ichi Nagakura, Tomoyuki Asaumi, Mai Tokunaga, Makoto Nishino, Kyohei Takahashi, Kiyotake Ogura, Sakura Sato, Motohiro Ebisawa
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Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses Allergol. Int. (IF 6.2) Pub Date : 2024-02-01 Kengo Kanai, Aiko Oka, Shin Kariya, Tazuko Fujiwara, Takaya Higaki, Seiichiro Makihara, Takenori Haruna, Maki Akamatsu, Kazunori Nishizaki, Mizuo Ando, Mitsuhiro Okano
Abstract not available
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Influence of household pet ownership and filaggrin loss-of-function mutations on eczema prevalence in children: A birth cohort study Allergol. Int. (IF 6.2) Pub Date : 2024-02-01 Kenji Toyokuni, Kiwako Yamamoto-Hanada, Limin Yang, Kouhei Hagino, Daisuke Harama, Marei Omori, Yasuaki Matsumoto, Daichi Suzuki, Kotaro Umezawa, Kazuma Takada, Mami Shimada, Seiko Hirai, Fumi Ishikawa, Sayaka Hamaguchi, Mayako Saito-Abe, Miori Sato, Yumiko Miyaji, Shigenori Kabashima, Tatsuki Fukuie, Emiko Noguchi, Kohta Suzuki, Yukihiro Ohya
The association between pet exposure in infancy, early childhood eczema, and mutations remains unclear. This was a birth cohort study performed in Tokyo, Japan. The primary outcome was current eczema based on questionnaire responses collected repeatedly from birth to 5 years of age. Generalized estimating equations and generalized linear modeling were used to evaluate the association. Data from 1448
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A systematic review and meta-analysis of macrolides in the management of adult patients with asthma Allergol. Int. (IF 6.2) Pub Date : 2024-01-30 Hiroshi Ohnishi, Toshihito Otani, Yoshihiro Kanemitsu, Tatsuya Nagano, Johsuke Hara, Masamitsu Eitoku
The efficacy of macrolides in the management of asthma has been studied but remains controversial. We conducted a systematic review and meta-analysis of macrolides in the management of adult patients with asthma. Randomized controlled trials of macrolides used in adult patients with asthma were searched for in MEDLINE, EMBASE, PsycINFO, Cochrane Library, CINAHL, and Igaku Chuo Zasshi databases to evaluate
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Cluster analysis of phenotypes, job exposure, and inflammatory patterns in elderly and nonelderly asthma patients Allergol. Int. (IF 6.2) Pub Date : 2024-01-29 Yung-Chi Chuang, Hsin-Hua Tsai, Meng-Chih Lin, Chao-Chien Wu, Yuan-Chung Lin, Tsu-Nai Wang
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15-Hydroxyeicosatrienoic acid induces nasal congestion by changing vascular functions in mice Allergol. Int. (IF 6.2) Pub Date : 2024-01-28 Noriko Ozaki, Naoaki Sakamoto, Daiki Horikami, Yuri Tachibana, Nanae Nagata, Koji Kobayashi, Yoshino Taira Arai, Masayoshi Sone, Kazuhiro Hirayama, Takahisa Murata
Nasal congestion in allergic rhinitis (AR) is caused by vascular hyperpermeability and vascular relaxation of the nasal mucosa. We previously detected high levels of a lipoxygenation metabolite of dihomogammalinolenic acid, 15-hydroxy-8Z,11Z,13E-eicosatrienoic acid (15-HETrE) in the nasal lavage fluid of AR model mice. Here, we investigated the effects of 15-HETrE on vascular functions associated with
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Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis Allergol. Int. (IF 6.2) Pub Date : 2024-01-17 Jungho Ahn, Seungyong Shin, Gi Chun Lee, Bo Eun Han, Eun Lee, Eun Kyo Ha, Jeewon Shin, Won Seok Lee, Ju Hee Kim, Man Yong Han
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Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study Allergol. Int. (IF 6.2) Pub Date : 2024-01-13 Sayaka Tsuji, Yuichi Adachi, Akiko Tsuchida, Kei Hamazaki, Kenta Matsumura, Hidekuni Inadera, the Japan Environment and Children's Study Group, Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Takeo Nakayama, Tomotaka Sobue, Masayuki Shima, Seiji Kageyama, Narufumi Suganuma, Shoichi Ohga, Takahiko Katoh
N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results. Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study
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A detailed intake-status profiling of seafoods in adult food–protein–induced enterocolitis syndrome patients Allergol. Int. (IF 6.2) Pub Date : 2023-12-27 Sho Watanabe, Ayako Sato, Misugi Uga, Naoki Matsukawa, Rina Kusuda, Hiroko Suzuki, Saori Nagashima, Tsunehito Yauchi, Yukihiro Ohya, Ichiro Nomura
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Exploring patient background and biomarkers associated with the development of dupilumab-associated conjunctivitis and blepharitis Allergol. Int. (IF 6.2) Pub Date : 2023-12-27 Makiko Kido-Nakahara, Daisuke Onozuka, Kenji Izuhara, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Ryo Saito, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji
Abstract not available
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Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice Allergol. Int. (IF 6.2) Pub Date : 2023-12-24 Yuki Kurihara, Hiroki Tashiro, Yoshie Konomi, Hironori Sadamatsu, Satoshi Ihara, Ayako Takamori, Shinya Kimura, Naoko Sueoka-Aragane, Koichiro Takahashi
Ozone is one of the triggers of asthma, but its impact on the pathophysiology of asthma, such as via airway inflammation and airway hyperresponsiveness (AHR), is not fully understood. Thymic stromal lymphopoietin (TSLP) is increasingly seen as a crucial molecule associated with asthma severity, such as corticosteroid resistance. Female BALB/c mice sensitized and challenged with house dust mite (HDM)
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Asian birth cohort studies Allergol. Int. (IF 6.2) Pub Date : 2023-12-19 Yukihiro Ohya
Abstract not available
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Best practices for multimodal clinical data management and integration: An atopic dermatitis research case Allergol. Int. (IF 6.2) Pub Date : 2023-12-14 Tazro Ohta, Ayaka Hananoe, Ayano Fukushima-Nomura, Koichi Ashizaki, Aiko Sekita, Jun Seita, Eiryo Kawakami, Kazuhiro Sakurada, Masayuki Amagai, Haruhiko Koseki, Hiroshi Kawasaki
In clinical research on multifactorial diseases such as atopic dermatitis, data-driven medical research has become more widely used as means to clarify diverse pathological conditions and to realize precision medicine. However, modern clinical data, characterized as large-scale, multimodal, and multi-center, causes difficulties in data integration and management, which limits productivity in clinical
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Genomic analysis reveals novel allergens of Blomia tropicalis Allergol. Int. (IF 6.2) Pub Date : 2023-12-07 Qing Xiong, Xiaoyu Liu, Angel Tsz-Yau Wan, Nat Malainual, Xiaojun Xiao, Hui Cao, Man-Fung Tang, Judy Kin-Wing Ng, Soo-Kyung Shin, Yang Yie Sio, Mingqiang Wang, Baoqing Sun, Ting-Fan Leung, Fook Tim Chew, Anchalee Tungtrongchitr, Stephen Kwok-Wing Tsui
Abstract not available
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Development and validation of a new asthma questionnaire to help achieve a high level of control in school-age children and adolescents Allergol. Int. (IF 6.2) Pub Date : 2023-12-07 Mayumi Matsunaga, Yasunori Sato, Mizuho Nagao, Masanori Ikeda, Chikako Motomura, Makoto Kameda, Yukinori Yoshida, Akihiko Terada, Isao Miyairi, Takao Fujisawa, the LePAT investigators
Maintaining good asthma control minimizes the risk of exacerbations and lung function decline and is a primary goal of asthma management. The Japanese Pediatric Asthma Guidelines (JPGL) employs different classification criteria for control status from other guidelines, stressing a higher level of control. Based on JPGL, we previously developed a caregiver-completed questionnaire for assessing and achieving
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Overviewing allergy epidemiology in Japan - Findings from birth cohorts (JECS and T-Child study) Allergol. Int. (IF 6.2) Pub Date : 2023-12-02 Kiwako Yamamoto-Hanada, Yukihiro Ohya
The escalating global allergy epidemic has emerged as a pressing and persistent challenge, exerting a profound impact on human health systems across centuries. This burgeoning predicament can be attributed to contemporary lifestyles, environmental influences, and genetic predispositions. The manifestation of allergy-related factors exhibits dynamic fluctuations contingent on temporal shifts, geographical
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Human basophils promote IgE-dependent oral allergen-induced anaphylaxis in humanized mice Allergol. Int. (IF 6.2) Pub Date : 2023-12-01 Yu-Hsien Lin, Satoko Tahara-Hanaoka, Akira Shibuya
Abstract not available