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Regulatory role of the Cpx ESR in bacterial behaviours. Virulence (IF 5.5) Pub Date : 2024-09-18 Jiajia Wan,Xuejun Gao,Feng Liu
The envelope demarcates the boundary between bacterial cell and its environment, providing a place for bacteria to transport nutrients and excrete metabolic waste, while buffering external environmental stress. Envelope stress responses (ESRs) are important tools for bacteria to sense and repair envelope damage. In this review, we discussed evidence that indicates the important role of the Cpx ESR
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Detection and differentiation of antinuclear antibodies in serum of dengue suspected patients with or without systemic autoimmune disease in Kolkata, India Virulence (IF 5.5) Pub Date : 2024-09-16 Rajendra Prasad Chatterjee, Shilpa Chatterjee, Debsopan Roy, Shyamalendu Chatterjee, Nilanjan Chakraborty
The pathophysiology of dengue may be influenced by antibodies released during infection. Several autoimmune diseases are accompanied by antinuclear antibodies (ANAs) but 8–10% of the general popula...
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Host-adaptive mutations in Chikungunya virus genome Virulence (IF 5.5) Pub Date : 2024-09-12 Xinhang Ning, Binghui Xia, Jiaqi Wang, Rong Gao, Hao Ren
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF), and its primary vectors are the mosquitoes Aedes aegypti and Aedes albopictus. CHIKV was initially endemic to Africa b...
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Antifungal activities of Equol against Candida albicans in vitro and in vivo. Virulence (IF 5.5) Pub Date : 2024-09-16 Fen Wang,Jinping Zhang,Qian Zhang,Zhangyong Song,Caiyan Xin
Candida albicans is an opportunistic fungal pathogen that can cause systemic infections in immunocompromised individuals. Morphological transition and biofilm formation are major virulence factors of C. albicans. Moreover, biofilm enhances resistance to antifungal agents. Therefore, it is urgent to identify new and effective compounds to target the biofilm of C. albicans. In the present study, the
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A glance at structural biology in advancing rice blast fungus research. Virulence (IF 5.5) Pub Date : 2024-09-16 Jongyi Yan,Lin Li,Jiandong Bao,Jiaoyu Wang,Xiaohong Liu,Fucheng Lin,Xueming Zhu
The filamentous fungus Magnaporthe oryzae is widely recognized as a notorious plant pathogen responsible for causing rice blasts. With rapid advancements in molecular biology technologies, numerous regulatory mechanisms have been thoroughly investigated. However, most recent studies have predominantly focused on infection-related pathways or host defence mechanisms, which may be insufficient for developing
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Isolation and characterization of a novel S1-gene insertion porcine epidemic diarrhea virus with low pathogenicity in newborn piglets. Virulence (IF 5.5) Pub Date : 2024-09-16 Mingjun Su,Yutao Wang,Junfang Yan,Xiangwen Xu,Huihua Zheng,Jiongze Cheng,Xiaoxu Du,Yijia Liu,Jiale Ying,Yulin Zhao,Ziqi Wang,Xing Duan,Yang Yang,Changyong Cheng,Zhihui Ye,Jing Sun,Dongbo Sun,Houhui Song
Porcine epidemic diarrhea virus (PEDV) causes diarrhea and vomiting in piglets, leading to a mortality rate of 100%. Due to the high frequency of mutation, it is important to monitor the evolution of PEDV and develop potential vaccine candidates. In this study, two PEDV strains (ZJ2022 and ZQ2022) were identified by PCR. These strains were subsequently isolated, and their genome sequences, growth characteristics
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Streptococcus suis 5'-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model. Virulence (IF 5.5) Pub Date : 2024-09-16 Simin Deng,Haojie Li,Chang Zhou,Jingyan Fan,Fuxin Zhu,Gexuan Jin,Jiali Xu,Jing Xia,Jing Wang,Zheng Nie,Rui Zhou,Houhui Song,Changyong Cheng
Streptococcus suis (S. suis) is an important swine bacterial pathogen and causes human infections, leading to a wide range of diseases. However, the role of 5'-nucleotidases in its virulence remains to be fully elucidated. Herein, we identified four cell wall-anchored 5'-nucleotidases (Snts) within S. suis, named SntA, SntB, SntC, and SntD, each displaying similar domains yet exhibiting low sequence
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Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in Pseudomonas aeruginosa. Virulence (IF 5.5) Pub Date : 2024-09-16 Germán G Vargas-Cuebas,Christian A Sanchez,Elise L Bezold,Gabrielle M Walker,Shehreen Siddiqui,Kevin P C Minbiole,William M Wuest
Cationic biocides (CBs), which include quaternary ammonium compounds (QACs), are employed to mitigate the spread of infectious bacteria, but resistance to such surface disinfectants is rising. CB exposure can have profound phenotypic implications that extend beyond allowing microorganisms to persist on surfaces. Pseudomonas aeruginosa is a deadly bacterial pathogen that is intrinsically tolerant to
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Type 2 hypersensitivity disorders, including systemic lupus erythematosus, Sjögren’s syndrome, Graves’ disease, myasthenia gravis, immune thrombocytopenia, autoimmune haemolytic anaemia, dermatomyositis, and graft-versus-host disease, are THαβ-dominant autoimmune diseases Virulence (IF 5.5) Pub Date : 2024-09-12 Tao-Ming Huang, Li-Jane Shih, Teng-Wei Hsieh, Kuo-Wang Tsai, Kuo-Cheng Lu, Min-Tser Liao, Wan-Chung Hu
The THαβ host immunological pathway contributes to the response to infectious particles (viruses and prions). Furthermore, there is increasing evidence for associations between autoimmune diseases,...
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Insect hypovirulence-associated mycovirus confers entomopathogenic fungi with enhanced resistance against phytopathogens. Virulence (IF 5.5) Pub Date : 2024-09-12 Li Sui,Yang Lu,Mengnan Xu,Jianfeng Liu,Yu Zhao,Qiyun Li,Zhengkun Zhang
Mycoviruses can alter the biological characteristics of host fungi, including change virulence or pathogenicity of phytopathogens and entomopathogenic fungi (EPF). However, most studies on the mycoviruses found in EPF have focused on the effects of the viruses on the virulence of host fungi towards insect pests, with relatively few reports on the effects to the host fungi with regard to plant disease
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Designing a multi-epitope subunit vaccine against Orf virus using molecular docking and molecular dynamics. Virulence (IF 5.5) Pub Date : 2024-09-11 Feng Pang,Qinqin Long,Shaobo Liang
Orf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry. The objective of this study is to design an immunoinformatics-based multi-epitope subunit vaccine against ORFV. Various immunodominant cytotoxic T lymphocytes (CTL), helper T lymphocytes (HTL), and B-cell epitopes from the B2L, F1L, and 080
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TolC facilitates the intracellular survival and immunomodulation of Salmonella Typhi in human host cells Virulence (IF 5.5) Pub Date : 2024-09-09 Ashraf Hussain, Eugene Boon Beng Ong, Prabha Balaram, Asma Ismail, Phua Kia Kien
Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a systemic infection that affects millions of people worldwide. S. Typhi can invade and survive within host cells, such as intesti...
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Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination Virulence (IF 5.5) Pub Date : 2024-09-06 Dongchang He, Xiyue Wang, Huiguang Wu, Kairui Cai, Xiaoli Song, Xiaoquan Wang, Jiao Hu, Shunlin Hu, Xiaowen Liu, Chan Ding, Daxin Peng, Shuo Su, Min Gu, Xiufan Liu
Vaccination is crucial for the prevention and mitigation of avian influenza infections in China. The inactivated H7N9 vaccine, when administered to poultry, significantly lowers the risk of infecti...
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Oral inoculation of Fusobacterium nucleatum exacerbates ulcerative colitis via the secretion of virulence adhesin FadA Virulence (IF 5.5) Pub Date : 2024-09-09 Donghao Li, Zongwei Li, Lei Wang, Yan Zhang, Shoubin Ning
Fusobacterium nucleatum (F. nucleatum), an anaerobic resident of the oral cavity, is increasingly recognized as a contributing factor to ulcerative colitis (UC). The adhesive properties of F. nucle...
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ATP synthase subunit ATP5B interacts with TGEV Nsp2 and acts as a negative regulator of TGEV replication Virulence (IF 5.5) Pub Date : 2024-09-09 Yanan Wang, Aoying Sun, Yaru Guo, Lingxiang Xin, Yanping Jiang, Wen Cui, Jiaxuan Li, Yijing Li, Li Wang
Coronavirus nonstructural protein 2 (Nsp2) is regarded as a virulence determinant and plays a critical role in virus replication, and innate immunity. Screening and identifying host cell proteins t...
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Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells Virulence (IF 5.5) Pub Date : 2024-09-06 Kris Gerard Alvarez, Lisa Goral, Abdulhadi Suwandi, Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Katrin Ehrhardt, Kumar Nagarathinam, Katrin Künnemann, Thomas Krey, Agnes Wiedemann, Gisa Gerold, Guntram A. Grassl
Human CD81 and CD9 are members of the tetraspanin family of proteins characterized by a canonical structure of four transmembrane domains and two extracellular loop domains. Tetraspanins are known ...
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acetylcysteine promotes doxycycline resistance in the bacterial pathogen edwardsiella tarda Virulence (IF 5.5) Pub Date : 2024-09-06 Juan Guo, Qingqiang Xu, Yilin Zhong, Yubin Su
Bacterial resistance poses a significant threat to both human and animal health. N-acetylcysteine (NAC), which is used as an anti-inflammatory, has been shown to have distinct and contrasting impac...
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Pathogenicity and virulence of chikungunya virus Virulence (IF 5.5) Pub Date : 2024-09-01 Wesley Freppel, Laurie A. Silva, Kenneth A. Stapleford, Lara J. Herrero
Chikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating symptoms. The viru...
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YjbH contributes to Staphylococcus aureus skin pathology and immune response through Agr-mediated α-toxin regulation. Virulence (IF 5.5) Pub Date : 2024-09-09 Aubrey K G McReynolds,Emma A Pagella,Miranda J Ridder,Olivia Rippee,Zachary Clark,Michaella J Rekowski,Michele T Pritchard,Jeffrey L Bose
Staphylococcus aureus is the most common cause of skin and soft tissue infections (SSTIs) with Methicillin-Resistant S. aureus (MRSA) strains being a major contributor in both community and hospital settings. S. aureus relies on metabolic diversity and a large repertoire of virulence factors to cause disease. This includes α-hemolysin (Hla), an integral player in tissue damage found in various models
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Simulating the clinical manifestations and disease progression of human sepsis: A monobacterial injection approach for animal modeling. Virulence (IF 5.5) Pub Date : 2024-09-01 Xuanwen Ru,Simiao Chen,Danlei Chen,Qingyi Shao,Wenxia Shao,Qing Ye
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, with great clinical heterogeneity, high morbidity, and high mortality. At the same time, there are many kinds of infection sources, the pathophysiology is very complex, and the pathogenesis has not been fully elucidated. An ideal animal model of sepsis can accurately simulate clinical sepsis
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Akkermansia muciniphila: A promising probiotic against inflammation and metabolic disorders Virulence (IF 5.5) Pub Date : 2024-08-27 Yanqing Zhao, Huijun Yang, Peng Wu, Shuguo Yang, Wenkun Xue, Biao Xu, Sirui Zhang, Bin Tang, Daoxiu Xu
Metabolic disease is a worldwide epidemic that has become a public health problem. Gut microbiota is considered to be one of the important factors that maintain human health by regulating host meta...
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The presence of differentiated C2C12 muscle cells enhances toxin production and growth by Clostridium perfringens type A strain ATCC3624 Virulence (IF 5.5) Pub Date : 2024-08-27 Jihong Li, Sameera Sayeed, Bruce A. McClane
Clostridium perfringens type A causes gas gangrene, which involves muscle infection. Both alpha toxin (PLC), encoded by the plc gene, and perfringolysin O (PFO), encoded by the pfoA gene, are impor...
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Advances in the pathogenesis and treatment of pneumococcal meningitis Virulence (IF 5.5) Pub Date : 2024-08-27 Yiyun Xu, Ji Wang, Xiaosong Qin, Jianhua Liu
Streptococcus pneumoniae is a common pathogen associated with community-acquired bacterial meningitis, characterized by high morbidity and mortality rates. While vaccination reduces the incidence o...
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Emergence of Staphylococcus argenteus in pediatrics: Molecular insights from a hospital in East China Virulence (IF 5.5) Pub Date : 2024-08-27 Chao Fang, Zheng Zhou, Jianping Li, Mingming Zhou
Staphylococcus argenteus is a novel species within the Staphylococcus aureus complex and can cause serious bloodstream infections (BSIs) in humans, which have been mainly reported in adults, especi...
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SsCyp86 modulates Sporisorium scitamineum mating/filamentation and pathogenicity through regulating fatty acid metabolism Virulence (IF 5.5) Pub Date : 2024-08-27 Enping Cai, Jiaru Deng, Ruqing Feng, Wenqiang Zheng, Yifang Wang, Meixin Yan, Changqing Chang
Fatty acid metabolism constitutes a significant and intricate biochemical process within microorganisms. Cytochrome P450 (CYP450) enzymes are found in most organisms and occupy a pivotal position i...
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Genome-wide characterization of structure variations in the Xiang pig for genetic resistance to African swine fever Virulence (IF 5.5) Pub Date : 2024-08-02 Fenfang Qi, Xia Chen, Jiafu Wang, Xi Niu, Sheng Li, Shihui Huang, Xueqin Ran
African swine fever (ASF) is a rapidly fatal viral haemorrhagic fever in Chinese domestic pigs. Although very high mortality is observed in pig farms after an ASF outbreak, clinically healthy and a...
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Measles virus: Continued outbreaks while striving for eradication Virulence (IF 5.5) Pub Date : 2024-08-02 David Jesse Sanchez
Published in Virulence (Vol. 15, No. 1, 2024)
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Evaluation of the immune responses of biological adjuvant bivalent vaccine with three different insertion modes for ND and IBD Virulence (IF 5.5) Pub Date : 2024-08-05 Wenying Sun, Shuang Li, Dun Niu, Ruihan Qin, Huimin Li, Zhiqiang Xue, Yunpeng Guo, Jinmiao Liu, Yijia Liu, Xinghao Jiang, Jiechao Yin, Xiaochen Guo, Guiping Ren
Infectious bursal disease (IBD) is a widespread problem in the poultry industry, and vaccination is the primary preventive method. However, moderately virulent vaccines may damage the bursa, necess...
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Functional characterization of BbEaf6 in Beauveria bassiana: Implications for fungal virulence and stress response Virulence (IF 5.5) Pub Date : 2024-08-01 Qing Cai, Juan-Juan Wang, Jia-Tao Xie, Dao-Hong Jiang
The Eaf6 protein, a conserved component of the NuA4 and NuA3 complexes in yeast and MOZ/MORF complexes in humans, plays crucial roles in transcriptional activation, gene regulation, and cell cycle ...
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LGG promotes activation of intestinal ILC3 through TLR2 receptor and inhibits salmonella typhimurium infection in mice Virulence (IF 5.5) Pub Date : 2024-07-30 Junhong Wang, Ming Gao, Jiarui Wang, Yan Zeng, Chunfeng Wang, Xin Cao
Salmonella is a foodborne pathogen that causes disruption of intestinal mucosal immunity, leading to acute gastroenteritis in the host. In this study, we found that Salmonella Typhimurium (STM) inf...
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Porcine reproductive and respiratory syndrome virus infects the reproductive system of male piglets and impairs development of the blood–testis barrier Virulence (IF 5.5) Pub Date : 2024-07-29 Bingzhou Huang, Fengqin Li, Dong You, Lishuang Deng, Tong Xu, Siyuan Lai, Yanru Ai, Jianbo Huang, Yuancheng Zhou, Liangpeng Ge, Xiu Zeng, Zhiwen Xu, Ling Zhu
Porcine reproductive and respiratory syndrome virus (PRRSV) causes a highly contagious disease that threatens the global swine industry. Recent studies have focused on the damage that PRRSV causes ...
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Current insights into human pathogenic phenuiviruses and the host immune system Virulence (IF 5.5) Pub Date : 2024-07-29 Chuan-Min Zhou, Ze-Zheng Jiang, Ning Liu, Xue-Jie Yu
Phenuiviruses are a class of segmented negative-sense single-stranded RNA viruses, typically consisting of three RNA segments that encode four distinct proteins. The emergence of pathogenic phenuiv...
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The complex interplay between encephalomyocarditis virus and the host defence system Virulence (IF 5.5) Pub Date : 2024-07-27 Jingying Xie, Adi Idris, Ruofei Feng
A variety of animals can be infected by encephalomyocarditis virus (EMCV). EMCV is the established causative agent of myocarditis and encephalitis in some animals. EMCV causes high fatality in suck...
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Recent global outbreaks of highly pathogenic and low-pathogenicity avian influenza A virus infections Virulence (IF 5.5) Pub Date : 2024-07-25 Hinh Ly
Published in Virulence (Vol. 15, No. 1, 2024)
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In turkeys, unlike chickens, the non-structural NS1 protein does not play a significant role in the replication and tissue tropism of the H7N1 avian influenza virus Virulence (IF 5.5) Pub Date : 2024-07-16 Maryna Kuryshko, Maria Landmann, Christine Luttermann, Reiner Ulrich, Elsayed M. Abdelwhab
The economic losses caused by high pathogenicity (HP) avian influenza viruses (AIV) in the poultry industry worldwide are enormous. Although chickens and turkeys are closely related Galliformes, tu...
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Dengue fever in the Americas Virulence (IF 5.5) Pub Date : 2024-07-11 Hinh Ly
Published in Virulence (Vol. 15, No. 1, 2024)
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Helicobacter pylori East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity Virulence (IF 5.5) Pub Date : 2024-07-09 Xiaofei Ji, Qianwen Wu, Xinying Cao, Shuzhen Liu, Jianhui Zhang, Si Chen, Jiangfan Shan, Ying Zhang, Boqing Li, Huilin Zhao
CagA is a significant oncogenic factor injected into host cells by Helicobacter pylori, which is divided into two subtypes: East Asian type (CagAE), characterized by the EPIYA-D motif, and western ...
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Pathogenicity and virulence of African swine fever virus Virulence (IF 5.5) Pub Date : 2024-07-07 Ines Ruedas-Torres, Bui Thi to Nga, Francisco J. Salguero
African swine fever (ASF) is a devastating disease with a high impact on the pork industry worldwide. ASF virus (ASFV) is a very complex pathogen, the sole member of the family Asfaviridae, which i...
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Unraveling host-pathogen dynamics in a murine model of septic peritonitis induced by vancomycin-resistant Enterococcus faecium Virulence (IF 5.5) Pub Date : 2024-07-01 Xin Yuan, Xiaolin Song, Xi Zhang, Lingfei Hu, Dongsheng Zhou, Jianlong Zhang, Chenxi Dai
Vancomycin-resistant Enterococcus faecium (E. faecium) infection is associated with higher mortality rates. Previous studies have emphasized the importance of innate immune cells and signalling pat...
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Prevalence and transmission of pretreatment drug resistance in people living with HIV-1 in Shanghai China, 2017–2021 Virulence (IF 5.5) Pub Date : 2024-06-27 Min Zhang, Yingying Ma, Zhenyan Wang, Gang Wang, Qianying Wang, Xin Li, Feng Lin, Chiyu Zhang
The implementation of pretreatment drug-resistance (PDR) surveillance among people living with HIV-1 (PLWH) is a top priority in countries using efavirenz (EFV)/nevirapine (NVP) for first-line ART....
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Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB and CagA induce protection against Helicobacter pylori infection in mice Virulence (IF 5.5) Pub Date : 2024-06-27 Qiong Liu, Yinpan Shang, Lu Shen, Xiaomin Yu, Yanli Cao, Lingbing Zeng, Hanchi Zhang, Zirong Rao, Yi Li, Ziwei Tao, Zhili Liu, Xiaotian Huang
Helicobacter pylori causes globally prevalent infections that are highly related to chronic gastritis and even development of gastric carcinomas. With the increase of antibiotic resistance, scienti...
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Research progress on the nonstructural protein 1 (NS1) of influenza a virus Virulence (IF 5.5) Pub Date : 2024-06-25 Xiaoyan Zhang, Yuying Zhang, Fanhua Wei
Influenza A virus (IAV) is the leading cause of highly contagious respiratory infections, which poses a serious threat to public health. The non-structural protein 1 (NS1) is encoded by segment 8 o...
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NagZ modulates the virulence of E. cloacae by acting through the gene of unknown function, ECL_03795 Virulence (IF 5.5) Pub Date : 2024-06-24 Xianggui Yang, Jun Zeng, Dan Wang, Qin Zhou, Xuejing Yu, Zhenguo Wang, Tingting Bai, Guangxin Luan, Ying Xu
β-N-acetylglucosaminidase (NagZ), a cytosolic glucosaminidase, plays a pivotal role in peptidoglycan recycling. Previous research demonstrated that NagZ knockout significantly eradicated AmpC-depen...
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Analyzing the factors affecting virus invasion by quantitative single-particle analysis Virulence (IF 5.5) Pub Date : 2024-06-23 Yi-Ning Hou, Li-Juan Zhang, Lei Du, Dan-Dan Fu, Jing Li, Liu Liu, Peng-Fei Xu, Ya-Wen Zheng, Dai-Wen Pang, Hong-Wu Tang
Viral diseases are among the main threats to public health. Understanding the factors affecting viral invasion is important for antiviral research. Until now, it was known that most viruses have ve...
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A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic Escherichia coli Virulence (IF 5.5) Pub Date : 2024-06-20 Nakjun Choi, Eunna Choi, Yong-Joon Cho, Min Jung Kim, Hae Woong Choi, Eun-Jin Lee
The emergence of multidrug-resistant bacteria poses a significant threat to human health, necessitating a comprehensive understanding of their underlying mechanisms. Uropathogenic Escherichia coli ...
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Ser/Thr protein kinase Stk1 phosphorylates the key transcriptional regulator AlgR to modulate virulence and resistance in Pseudomonas aeruginosa Virulence (IF 5.5) Pub Date : 2024-06-20 Rui Li, Xuan Zhu, Pengfei Zhang, Xuan Wu, Qian Jin, Jianyi Pan
Pseudomonas aeruginosa is one of the leading causes of nosocomial infections worldwide and has emerged as a serious public health threat, due in large part to its multiple virulence factors and rem...
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Screening optimal DC-targeting peptide to enhance the immune efficacy of recombinant Lactobacillus expressing RHDV VP60 Virulence (IF 5.5) Pub Date : 2024-06-20 Tian Xia, Xiao Lu, Deming Kong, Tiantian Guo, Yueyi Gao, Lingxiang Xin, Yanping Jiang, Xiaona Wang, Zhifu Shan, Jiaxuan Li, Han Zhou, Wen Cui, Xinyuan Qiao, Lijie Tang, Yijing Li, Li Wang
Dendritic cells (DCs) present an ideal target for delivering immunogenic cargo due to their potent antigen-presenting capabilities. This targeting approach holds promise in vaccine development by e...
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Exogenous NADH promotes the bactericidal effect of aminoglycoside antibiotics against Edwardsiella tarda Virulence (IF 5.5) Pub Date : 2024-06-17 Yilin Zhong, Juan Guo, Ziyi Zhang, Yu Zheng, Manjun Yang, Yubin Su
The global surge in multidrug-resistant bacteria owing to antibiotic misuse and overuse poses considerable risks to human and animal health. With existing antibiotics losing their effectiveness and...
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HIF-1α interacting with miR-2013-3p regulates pathogen-induced energy production changes via targeting glutamate dehydrogenase in the sea urchin Strongylocentrotus intermedius Virulence (IF 5.5) Pub Date : 2024-06-18 Bingyu Ning, Jingxian Sun, Dongyao Cui, Shuxin Zhang, Yaoyao Zhan, Yaqing Chang
To investigate the functions of hypoxia inducible factor-1α (HIF-1α) homologs, we cloned and characterized the full-length cDNA of a novel HIF-1α homolog (SinHIF-1α) from the sea urchin Strongyloce...
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The pathogenicity and virulence of the opportunistic pathogen Staphylococcus epidermidis Virulence (IF 5.5) Pub Date : 2024-06-13 Órla Burke, Merve S. Zeden, James P. O’Gara
The pervasive presence of Staphylococcus epidermidis and other coagulase-negative staphylococci on the skin and mucous membranes has long underpinned a casual disregard for the infection risk that ...
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Recombination and amino acid point mutations in VP3 exhibit a synergistic effect on increased virulence of rMDPV Virulence (IF 5.5) Pub Date : 2024-06-13 Jianye Wang, Wanmei Li, Xiaoyan Gong, Zhixian Wang, Yu Wang, Jueyi Ling, Zhiwei Jiang, Guoqiang Zhu, Yufeng Li
Recombinant Muscovy duck parvovirus (rMDPV) is a product of genetic recombination between classical Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV). The recombination event took place wit...
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Essential roles of Rad6 in conidial property, stress tolerance, and pathogenicity of Beauveria bassiana Virulence (IF 5.5) Pub Date : 2024-06-11 Yi Guan, Haomin He, Yuhan Guo, Longbin Zhang
Rad6 functions as a ubiquitin-conjugating protein that regulates cellular processes in many fungal species. However, its role in filamentous entomopathogenic fungi remains poorly understood. This s...
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Maternal and neonatal outcomes and clinical laboratory testing of pregnant women with COVID-19 during the BA.5.2/BF.7 surge Virulence (IF 5.5) Pub Date : 2024-06-04 Jiali Cao, Zehong Huang, Jing Zeng, Jumei Liu, Weilun Zuo, Zhiying Su, Yujuan Chen, Weiwei Yu, Huiming Ye
The impact of COVID-19 on pregnant women and newborns continues to be a critical societal concern. However, the majority of research focuses on the disease resulting from the early pandemic variant...
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Pathogenicity and virulence of O’nyong-nyong virus: A less studied Togaviridae with pandemic potential Virulence (IF 5.5) Pub Date : 2024-05-26 Samuel Tong Jia Ming, Katrina Tan Yi Jun, Guillaume Carissimo
O’nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the Togaviridae family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarth...
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The Salmonella virulence protein PagN contributes to the advent of a hyper-replicating cytosolic bacterial population Virulence (IF 5.5) Pub Date : 2024-05-28 Sébastien Holbert, Emilie Barilleau, Jin Yan, Jérôme Trotereau, Michael Koczerka, Mégane Charton, Yves Le Vern, Julien Pichon, Guntram A. Grassl, Philippe Velge, Agnès Wiedemann
Salmonella enterica subspecies enterica serovar Typhimurium is an intracellular pathogen that invades and colonizes the intestinal epithelium. Following bacterial invasion, Salmonella is enclosed w...
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Characteristics of Norovirus capsid protein-specific CD8+ T-Cell responses in previously infected individuals Virulence (IF 5.5) Pub Date : 2024-05-29 Taojun He, Yilin Deng, Fang Zhang, Jin Zhang, Luhong Zhu, Qinjin Wang, Jie Ning, Hui Wu, Hanmei Yuan, Bin Li, Chao Wu
Norovirus (NV) infection causes acute gastroenteritis in children and adults. Upon infection with NV, specific CD8+ T cells, which play an important role in anti-infective immunity, are activated i...
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Integrative and conjugative elements of Pasteurella multocida: Prevalence and signatures in population evolution Virulence (IF 5.5) Pub Date : 2024-05-29 Jiao He, Zhishuang Yang, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng, Dekang Zhu
Pasteurella multocida (P. multocida) is a bacterial pathogen responsible for a range of infections in humans and various animal hosts, causing significant economic losses in farming. Integrative an...
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Tobramycin-resistant small colony variant mutant of Salmonella enterica serovar Typhimurium shows collateral sensitivity to nitrofurantoin Virulence (IF 5.5) Pub Date : 2024-05-26 Chang-Zhen Wang, Yue-Jun Zhang, Yue-Fei Chu, Long-Gen Zhong, Jin-Peng Xu, Liu-Yan Liang, Teng-Fei Long, Liang-Xing Fang, Jian Sun, Xiao-Ping Liao, Yu-Feng Zhou
The increasing antibiotic resistance poses a significant global health challenge, threatening our ability to combat infectious diseases. The phenomenon of collateral sensitivity, whereby resistance...
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M1-type polarized macrophage contributes to brain damage through CXCR3.2/CXCL11 pathways after RGNNV infection in grouper Virulence (IF 5.5) Pub Date : 2024-05-23 Kaishan Liang, Minlin Zhang, Jiantao Liang, Xiaoling Zuo, Xianze Jia, Jinhong Shan, Zongyang Li, Jie Yu, Zijie Xuan, Liyuan Luo, Huihong Zhao, Songyong Gan, Ding Liu, Qiwei Qin, Qing Wang
The vertebrate central nervous system (CNS) is the most complex system of the body. The CNS, especially the brain, is generally regarded as immune-privileged. However, the specialized immune strate...