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New onset diabetic ketoacidosis in a renal transplant recipient Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-29 Havird McLean Skalak, Kaitlyn Haas, Melissa Laub PharmD BCTXP BCPS, Laura L. Mulloy DO FACP FASN FAST
Post-transplant diabetes mellitus (PTDM) is a well-known solid organ transplant complication, which can be related to immunosuppressants, particularly tacrolimus. We report an unusual presentation of PTDM with diabetic ketoacidosis (DKA). This is unique as PTDM typically resembles Type 2 DM, whereas DKA is associated with Type 1 DM and has rarely been reported as a complication of tacrolimus. A 38-year-old
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Association between cardiovascular health and serum vitamin D and its interaction with prediabetes and diabetes Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-24 Ying Chen MBBS, Haiyu Zhang MD, Yanbing Pan MM, Yanzi Zhang MM, Yuxuan Yang MBBS, Lu Liu MBBS, Qiuting Jia MBBS, Yongle Wang MBBS, Yihui Kong MD
Prediabetes and diabetes are common and serious public health problems, and high blood glucose can lead to serious cardiovascular complications. The purpose of this article was to explore the link between CVH levels and the incidence of prediabetes and diabetes in people over 20 years old, and whether serum vitamin D status could alter this relationship. Data, from six consecutive cycles of the NHANES
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Useful biomarkers for predicting poor prognosis of patients with drug-induced liver injury: A retrospective cohort study Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-23 Hsueh-Chien Chiang M.D., I-Chin Wu M.D. PhD
Drug-induced liver injury (DILI) plays an important role in liver failure and causes mortality. Patients with DILI compatible with Hy's law are associated with poorer outcomes. However, the predictive accuracy of Hy's law is not good enough in clinical practice. This study aimed to investigate the optimal values of biomarkers associated with the prognosis of DILI. From June 1, 2014-May 30, 2022, patients
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1,25-dihydroxyvitamin D mediated hypercalcemia in seminoma Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-22 Julianna Sim, Jonathan Irvin, Nezam Altorok MD
Hypercalcemia has rarely been associated with seminomas. Due to the limited data available, the pathophysiology of hypercalcemia in seminoma has not been established in literature. We present a case of a 59-year-old male who presented with weakness, abdominal fullness, fatigue, constipation, and a 14 lb unintentional weight loss. On initial presentation he was found to be hypercalcemia with calcium
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Mixed glandular neuroendocrine carcinoma of the endometrium with hypercalcemic crisis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-21 Mei Luo MD, Xiaoxia Yu MD, Zhongpei Chen MD, Zhenhan Li MD
To explore the ideas and research progress in diagnosing and treating hypercalcemic crisis in patients with cancer. We reviewed the clinical data, diagnosis and treatment of hypercalcemic crisis in a patient with mixed glandular neuroendocrine carcinoma of the endometrium. The patient had gastrointestinal symptoms and acute renal impairment as the main manifestations, and the blood biochemical indexes
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Effect of mean heart rate on 30-day mortality in older patients with sepsis: Data from the MIMIC-IV database Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-21 Qiang Zhou BD, Jianing Li BD, Yuxiu Miao MD, Na Li MD
Sepsis is a critical condition with a significant risk of mortality. Advanced age is one factor in increasing mortality in intensive care.
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TPOAb Indicates neuroendocrine tumor in autoimmune gastritis: A retrospective study of 91 patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-21 Bo Li MS, Honggang Jiang MM, Congbo Cai MB, Hongtan Chen MD
The association between serological indexes and occurrence of complications in patients with autoimmune gastritis (AIG) remains unclear. 91 patients with AIG were recruited and their clinical information were collected. The differences between serological indexes and complications of AIG were analyzed. And potential biomarker for early prediction and diagnosis of AIG with complications was explored
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Evaluating outcomes of transjugular intrahepatic portosystemic shunt procedure among Native Americans Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-21 Renxi Li BS, Shawn Sarin MD
This study aims to explore racial disparities in immediate outcomes of Transjugular Intrahepatic Portosystemic Shunt (TIPS) among Native Americans, a group that have higher prevalence of liver cirrhosis but were the “invisible group” in previous TIPS studies due to their small population size. The study identified Native Americans and Caucasians who underwent TIPS in National/Nationwide Inpatient Sample
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Elevated triglyceride-glucose index as a predictor of carotid plaque incidence: Insights from a comprehensive meta-analysis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-19 Arankesh Mahadevan MBBS, Bhavin A. Patel MD, Sashwath Srikanth MD, Raja Godasi MBBS, Rupak Desai MBBS
Early detection of carotid plaque (CP) can help reduce the burden of ASCVD in the general population. CP and triglyceride-glucose index (TyGi) are associated with insulin resistance. We performed a meta-analysis exploring the association of TyGi levels with the incidence of CP. A systematic search of PubMed, Scopus, and Google Scholar till September 2023 reporting TyGi and CP identified 67 studies
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A rare case of spontaneous hemoperitoneum in a bone marrow transplant recipient on VV-ECMO Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-19 Patrick Donabedian MD, Amir M. Emtiazjoo MD MSc, Mindaugus Rackauskas MD PhD, Philip Efron MD FCCM, Cynthia Gries MD MSc, Melissa Burger MD, Letitia Bible MD, Victoria Reams PharmD BCTXP, Marc O. Maybauer MD PhD, Biplab K. Saha MD
A 53-year-old man with acute myeloid leukemia received an allogeneic hematopoietic cell transplant (HCT) from a matched unrelated donor. One month after his transplantation, he developed ARDS requiring initiation of VV-ECMO. He suffered from pancytopenia, managed with frequent transfusions, granulocyte-colony stimulating factor (G-CSF) and weekly thrombopoietin receptor agonist. On ECMO day 17, the
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Effect of different shock conditions on mesenteric hemodynamics Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-19 Hao Pu MSc, Wen Li MSc, Gui Wang MSc, ShuJun Zhou MSc
Reduced effective circulating blood volume and impaired peripheral tissue perfusion play an important role in the pathophysiology of shock. However, there have been no studies examining the relationship between Doppler ultrasound of the superior mesenteric artery (SMA) under different shock conditions. We evaluated a total of 85 patients, including 63 patients with different types of shock and 22 in
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Severe hyponatremia secondary to syndrome of inappropriate antidiuretic hormone (SIADH): A rare cause of takotsubo (stress) cardiomyopathy Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-19 Asad Mussarat MD, Zachary Stielper MD, Christopher Hayden MD, Shane Guillory MD
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Epidural block with lidocaine ameliorates kidney function deterioration and fibrosis of chronic kidney disease in rats Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-17 Xin Xu MS, Buwei Yu MD, Youwen Lv MS, Qing Cai MS, Mengya Li MS, Guifeng Li MS, Shunjie Chen MD, Qifang Li MD
According to evidences from clinical practices and experiments, renal denervation achieved by removing both the afferent and sympathetic nerves has therapeutic impacts on poor renal function and hypertension in chronic kidney disease (CKD). Epidural anesthesia is presumed to function on the target spine segments with a complete sympathetic block. Based on this perspective, we hypothesized that epidural
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A simple nomogram for predicting the 90-day mortality of community-acquired pneumonia in the ICU Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-17 Ying Sheng PhD, Huishui Dai MD, Qifang Shi PhD, Wenlong Zheng PhD
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Contemporary awareness of nonalcoholic fatty liver disease and viral hepatitis based on the stage Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-17 Donghee Kim MD PhD, Richie Manikat MD, Karn Wijarnpreecha MD MPH, George Cholankeril MD MSECR, Aijaz Ahmed MD
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A case of Winkia neuii (Actinomyces neuii) vertebral osteomyelitis and review of the literature Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-16 Nicholas Richwagen MD, Destinee Morris MD, Rita Paulis MD, Daniel Murphy MD, Matthew Perkins MD MTM&H, Edwin Kamau PhD D(ABMM)
This case report presents an unusual occurrence of () vertebral osteomyelitis in a 55-year-old male patient with diabetes mellitus. is a distinct species formerly placed within the genus, exhibiting unique morphological and clinical characteristics. Vertebral osteomyelitis caused by species is rare, with only one prior case reported in the literature. The patient was successfully managed with a combination
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Clinical characteristics of primary biliary cirrhosis - idiopathic inflammatory myopathy overlap syndrome: A single center study Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-08 Juan Wu MD, Yue Yin MD PhD, Xinxin Han MD PhD, Hong Di MD PhD, Yingdong Han MD PhD, Min Shen MD PhD, Yun Zhang MD, Xuejun Zeng MD PhD
Primary biliary cirrhosis–idiopathic inflammatory myopathy (PBC-IIM) overlap syndrome (OS) is a rare condition in which cardiac involvement is observed. We aimed to characterize the clinical features and associated factors of PBC-IIM OS patients with cardiac involvement. Patients with PBC-IIM OS that visited our hospital from January 1983 to December 2021 were enrolled. Clinical presentations and laboratory
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Acute urticaria and cardiovascular diseases Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-08 Eli Magen MD, Eugene Merzon MD, Ilan Green MD, Israel Magen MD, Avivit Golan-Cohen MD, Shlomo Vinker MD, Ariel Israel MD PhD
Acute urticaria (AU), characterized by sudden skin wheals, has been associated with various triggers. While chronic urticaria's cardiovascular comorbidities have been studied, AU's associations remain largely unexplored. This study aimed to identify prevalent cardiovascular comorbidities in AU patients and assess their clinical significance. A retrospective cohort study used data from Leumit Health
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The closed loop of the circCLIP2/miR-361-3p/STAT2 signaling axis regulates the progression of cervical cancer Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-08 Qian Zhang MM, Wang Cai MM
Circular RNAs (circRNAs) are involved in tumorigenesis and the progression of cancer through various pathways. However, the detailed regulatory mechanisms of circRNAs in cervical cancer are not fully understood. The present study was designed to explore the biological functions and potential mechanisms of circCLIP2 (has_circ_0001717) in cervical cancer. The expression profiles of circRNAs in cancerous
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Visceral adipose tissue area predicts major adverse kidney events in patients with acute necrotizing pancreatitis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-08 Xihong Zhang MD, Wenjian Mao MD, Lu Ke PhD, Tiejun Wu MD, Minyi Xu MPH, Yunze Tan MD, Yu Liu MD, Luyu Liu MSc, Gang Li MD, Jing Zhou MD, Jingzhu Zhang MSc, Bo Ye MD, Zhihui Tong MD, Jianqiang Guo MD, Weiqin Li MD
Given the previously reported harmful effects of abdominal fat burden on kidney function, we aim to investigate the relationship between major adverse kidney events within 30 days (MAKE30) and abdominal obesity in acute necrotizing pancreatitis (ANP) patients and explore the underlying risk factors. A retrospective cohort study of all patients admitted within 72 h after the first episode of ANP to
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Soluble RAGE attenuates myocardial I/R injury by suppressing interleukin-6 Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-06 Jie Zhang MD, Jian Liu MD, Jiming Yin MD, Xue Jiang MD, Lu Chen MD, Xiangjun Zeng PhD, Caixia Guo MD PhD
Inflammatory responses play a central role in myocardial ischemia/reperfusion (I/R) injury. Previous studies have demonstrated that the receptor for advanced glycation end-products (RAGE) is involved in the pro-inflammatory process of myocardial I/R injury by binding to diverse ligands. Thus, the inhibitory effects of soluble receptor for advanced glycation end-products (sRAGE), a decoy receptor for
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Anti-IgLON5 disease: A case with intestinal obstruction and peripheral neuropathy Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-06 Yunwen Qi MMS, Yongling Zheng MMS, Zhiyou Cai MD, Xiaogang Zhang MD
IgLON5 autoimmunity is a novel antibody-mediated disorder characterized by serum and/or cerebrospinal fluid (CSF) positivity for IgLON5 antibody. Anti-IgLON5 disease mainly manifests as sleep disturbances, movement disorders and brainstem syndromes. In this study, we report the case of a patient with anti-IgLON5 disease who presented with abdominal distension, abdominal pain, intermittent dysuria and
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When metabolic comorbidities and risk of malnutrition coexist: The new era of inflammatory bowel disease Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-08-02 Sandra García-Mateo M.D., Samuel Jesús Martínez-Domínguez M.D., Carla Jerusalén Gargallo-Puyuelo PhD, María Teresa Arroyo Villarino PhD, Viviana Laredo PhD, Beatriz Gallego M.D., Erika Alfambra M.D., Borja Sanz M.D., Fernando Gomollón PhD
Metabolic dysfunction-associated steatotic liver disease (MASLD) and risk of malnutrition can coexist in patients with inflammatory bowel disease (IBD). We performed a malnutrition risk assessment as part of the standard follow-up of IBD patients and studied the potential risk factors for being at risk of malnutrition based on the presence or absence of MASLD. The Malnutrition Universal Screening Tool
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The prognostic value of the MAGGIC risk score in patients with acute pulmonary embolism Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-31 Inanc Artac MD, Dogan Ilis MD, Muammer Karakayali MD, Timor Omar MD, Ayca Arslan MD, Ihsan Topaloğlu MD, Yavuz Karabag MD, Suleyman Karakayon MD, Ibrahim Rencuzogullari MD
Acute pulmonary embolism (PE) is a potentially life-threatening condition characterized by the sudden blockage of the pulmonary arteries. Although the MAGGIC risk score has emerged as a valuable tool in predicting outcomes in patients with chronic heart failure, it has also been demonstrated and identified as a prognostic model in various cardiac diseases other than heart failure. In this study, we
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Iron metabolism biomarkers: Linking anemia and acute exacerbations in COPD patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-30 Yakun Liu M.Med, Jinlong Gao M.Med, Xiaoling Wang M.Med, Zhen Yang M.Med, Xinhua Wang M.Med, Yi Zhao M.Med
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A retrospective study on the efficacy of pegfilgrastim-filgrastim combination regimen in the mobilization for autologous stem cell transplantation in lymphoma patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-30 Xingtong Wang MD PhD, Wei Guo MD PhD, Junna Li MD, Jia Li MD PhD, Yangzhi Zhao MD PhD, Beibei Du MD PhD, Ou Bai MD PhD
The high mobilization failure rate with the mobilization strategy of combining chemotherapy and filgrastim (rhG-CSF) in autologous hematopoietic stem cell transplantation (auto-HSCT) in lymphomas is one of the unresolved issues. Whether the combination of polyethylene glycol filgrastim [pegfilgrastim (PEG-FIL), PEG-rhG-CSF] and filgrastim (FIL) improves the mobilization success rate and the timing
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Predictive value of peripheral neutrophil count on admission for young patients with acute coronary syndrome Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-30 Jia Zheng MD, Tingting Li MD, Fang Hu PhD, Bingwei Chen MD, Mengping Xu PhD, Shuangbing Yan MD, Chengzhi Lu MD PhD
The present study aimed to explore the relationship between neutrophil count on admission and major adverse cardiovascular and cerebrovascular events (MACCE) and left ventricular ejection fraction (LVEF) during hospitalization in young ACS patients, which have rarely been investigated in previous studies. This study included 400 young ACS patients (<45 years old) who underwent coronary angiography
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Brucella as a cause of severe sepsis: Case series and brief review Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-30 Linlin Deng MM, Jiazhen Yu, Hongyan Li MM, Hong Zhang
Brucellosis is a serious public health problem worldwide and can affect any organ system. Due to brucellosis's variable clinical presentation, ranging from subclinical to fully symptomatic, and limited available information, it poses a diagnostic challenge. In this study, we reported a case series of patients with diverse presentations. In addition, we briefly described the pathophysiology and mechanisms
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Anesthetic challenges in curschmann Steinert's disease (DM1): The importance of respiratory assessment Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-30 María Fernanda García Aguilera MD PhD, Carlos Manterola MD PhD, Nayely García-Méndez MD PhD
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Patterns of gastroenterology specialty referral for primary care patients with metabolic dysfunction-associated steatotic liver disease Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-27 John F.G. Bobo MD, Brad A. Keith MD, Justin Marsden MBA, Jingwen Zhang MS, Andrew D. Schreiner MD MSCR
As metabolic dysfunction-associated steatotic liver disease (MASLD) management extends into primary care, little is known about patterns of specialty referral for affected patients. We determined the proportion of primary care patients with MASLD that received a gastroenterology (GI) consultation and compared advanced fibrosis risk between patients with and without a referral. This retrospective study
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Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-20 Ying Xu M.D., Yajun Qian Ph.D., Pei Liang M.D., Ning Liu M.D., Danjiang Dong M.D., Qin Gu M.D., Jian Tang M.D.
The purpose was to explore the correlation between refeeding hypophosphatemia and delirium and analyze the related factors in critically ill patients. We conducted a retrospective review of critically ill patients admitted to Nanjing Drum Tower Hospital between September 2019 and March 2021. The patients were divided into delirium and nondelirium groups. Demographic data, underlying diseases, laboratory
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Clinical outcomes and associated factors with mortality in systemic sclerosis patients with sarcopenia Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-20 Sirada Hongkanjanapong M.D., Patnarin Pongkulkiat M.D., Ajanee Mahakkanukrauh M.D., Siraphop Suwannaroj M.D., Chingching Foocharoen M.D.
Despite the high incidence of sarcopenia in systemic sclerosis (SSc) patients, there is currently limited evidence on their outcomes. Our study aimed to determine clinical courses, outcomes, and identify factors associated with mortality in the SSc patients with sarcopenia. A historical cohort study was conducted in 180 adult SSc patients diagnosed with sarcopenia according to the criteria of Asian
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COVID-19 associated cutaneous polyarteritis nodosa Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-20 Milena Mimica MD., Eddy Mora MD., Loreto Massardo MD.
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COPD overlap conditions: Clinical and therapeutic implications✰ Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-17 Abdullah Jarrah MD, Mohammed T Awad MD MPH, Cassondra Cramer-Bour MD, Ayman O. Soubani MD
Chronic Obstructive Pulmonary Disease (COPD) is a complex pulmonary condition characterized by chronic airflow limitation. Within the spectrum of COPD, distinct overlap conditions exist, including Asthma-COPD Overlap (ACO), COPD-Obstructive Sleep Apnea (COPD-OSA), Combined Pulmonary Fibrosis and Emphysema (CPFE), and Bronchiectasis-COPD Overlap (BCO). This review provides a comprehensive overview of
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A machine learning approach for phenotyping acute decompensated pulmonary hypertension patients admitted to the ICU Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-17 Marcos Vinicius Fernandes Garcia MD PhD, Rogerio Souza MD PhD, Pedro Caruso MD PhD
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Dyspnea and long COVID patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-17 Kenneth Nugent MD, Gilbert Berdine MD
Patients with prior COVID-19 infections often develop chronic post-COVID symptoms, such as fatigue and dyspnea. Some patients have residual pulmonary disorders with abnormal pulmonary function tests and/or chest radiographs to explain their dyspnea. However, other patients appear to have dyspnea that is out of proportion to any measurable change in lung function. Some of these patients have abnormal
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Monitor-related changes consistent with paradoxical pulse Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-16 Hiroki Matsuura MD, Masayuki Kishida MD PhD
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Use of mycophenolate mofetil for the treatment of fibrotic hypersensitivity pneumonitis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-14 Ana Casal, Juan Suárez-Antelo, Francisco Gude, Óscar Lado-Baleato, Borja Otero, María E. Toubes, Lucía Ferreiro, Nuria Rodríguez-Núñez, Luis Valdés
The optimal treatment of fibrosing hypersensitivity pneumonitis (fHP) is not well understood. The aim of the study was to obtain information about the usefulness of mycophenolate mofetil (MMF) in its treatment. Quasi-experimental analysis of patients diagnosed with fHP and treated with MMF for one year, in a single centre. From the start of treatment, data collection was prospective. 73 were included
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Systematically investigate the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-14 Jingxin Mao PhD, Lihong Tan MD, Cheng Tian MD, Wenxiang Wang PhD, YanLin Zou MD, Zhaojing Zhu PhD, Yan Li MD
Whether is an effective drug in treatment of ulcerative colitis (UC) and how it exhibit activity effect on UC is unclear. TCMSP, GeneCards, String, and DAVID database were used to screening target genes construct PPI network and performed for GO and KEGG pathway enrichment analysis respectively. Molecular docking and animal experiment were performed. The body weight and disease activity index (DAI)
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Association of estimated plasma volume with new onset acute kidney injury in hospitalized COVID-19 patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-14 Shahin Isha MBBS MD, Prasanth Balasubramanian MBBS MD, Lekhya Raavi MBBS MD, Abby J. Hanson BS, Anna Jenkins BS, Parthkumar Satashia MBBS MD, Arvind Balavenkataraman MBBS MD, Iván A. Huespe MD, Aysun Tekin MD, Vikas Bansal MBBS MPH, Sean M. Caples DO MS, Syed Anjum Khan MD, Nitesh K. Jain MBBS, Abigail T. LaNou MD, Rahul Kashyap MBBS MBA, Rodrigo Cartin-Ceba MD, Bhavesh M. Patel MD, Houssam Farres
To explore the association of estimated plasma volume (ePV) and plasma volume status (PVS) as surrogates of volume status with new-onset AKI and in-hospital mortality among hospitalized COVID-19 patients. We performed a retrospective multi-center study on COVID-19-related ARDS patients who were admitted to the Mayo Clinic Enterprise health system. Plasma volume was calculated using the formulae for
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Association between ABO blood groups and hyperhomocysteinemia in the Chinese Han population Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-14 Xiaoqing Dai MA, Wan Lin MA, Zhengyu Lin MA, Xinyin Xie MA, Min Yu pH D
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Electrical storm after acute myocardial infarction treated with Radiofrequency ablation under the Escort of ICD Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-11 Li-Juan Qu MM, Zhi-Jun Zhang MD
The occurrence of ventricular tachycardia (VT) in patients with acute myocardial infarction (AMI) is associated with poor prognosis. Drug therapy and implantable cardioverter-defibrillators (ICDs) are effective methods to prevent sudden death. Radiofrequency (RF) catheter ablation can map the matrix and mechanism of VT, thereby effectively reducing the occurrence of ICD discharge. This paper reports
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Meta-analysis of renin angiotensin aldosterone modulators mitigating Atrial Fibrillation risk in hypertensive patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-10 Arankesh Mahadevan MBBS, Sushmitha Garikipati MBBS, Samir Vanani MBBS, Dakshin Meenashi Sundaram MBBS, Ashley Thompson-Edwards MBBS, Nafisa Reyaz MBBS, Kalaivani Babu MBBS, Srinishant Rajarajan MBBS, Dhayashri Dhavapalani MBBS, Dharshana Prem Anand MBBS, Advait Vasavada MBBS, Rupak Desai MBBS
Hypertension is associated with left ventricular hypertrophy/enlargement/fibrosis and atrial ectopic rhythm, leading to an increased risk of Atrial Fibrillation (AF). We aimed to stratify the effect of Angiotensin Converting Enzyme Inhibitors (ACEi) and Angiotensin Receptor Blockers (ARB) on the risk of AF. PubMed, Scopus, and Google Scholar databases were screened, and cross-citation was conducted
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Global longitudinal strain and the risk of major adverse cardiac events in post-myocardial infarction patients: A retrospective cohort study Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-10 Qiao Guo MD, Weilong Hong MD, Dan Li MD, Ruixue Liu MD, Lumiao Liu MD, Xuxin Tan MD, Guangyou Duan PhD, He Huang PhD, Chenyang Duan PhD
This study evaluates the relationship between global longitudinal strain (GLS) and late major adverse cardiovascular events (MACEs) in patients after acute myocardial infarction (AMI). Data of newly diagnosed AMI patients between March 2010 and July 2014 were retrospectively evaluated. The patients underwent serial echocardiography at admission and at third and sixth months post-admission. We calculated
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Testosterone concentrations and associated predictors in men with cystic fibrosis: A retrospective, single-center study Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-10 Ishaan Jathal, Yanhua Wang, José Nilo G. Binongo, Crystal Cobb, William R. Hunt, Farah N. Khan, Vin Tangpricha
Men with cystic fibrosis (CF) have sexual health concerns such as delayed puberty, infertility, and hypogonadism. The causes and prevalence of hypogonadism have not been well studied. The purpose of this study was to determine the prevalence of a low testosterone concentration in men with CF. This retrospective study was approved by the Emory University Institutional Review Board (IRB). Data were extracted
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Outcome of Guillain-Barré syndrome with bulbar palsy Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-09 Jayantee Kalita MD, Roopali Mahajan MD, Sanjeev K. Bhoi MD, Usha K Misra MD
Elective intubation is advocated in Guillain-Barré syndrome (GBS) with bulbar palsy to prevent aspiration pneumonia and lung collapse. We evaluate the outcome of GBS patients with bulbar palsy, and also compare the risks and benefits of intubation and MV in them. 187 GBS patients with bulbar palsy from a cohort of 547 GBS registry were analyzed. Detailed clinical records and peak disability on a 0-6
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Kartagener's syndrome Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-09 Yuan Zeng, Guilin Peng, Jianxing He, Chao Yang, Xin Xu
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Early growth response factor 3 regulates coronary atherosclerosis through the NF-κB signaling pathway and VEGF expression Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-09 Zumureti Abudukeyimu MD, Junyi Luo PhD, Fang Liu MD, Yanling Ma MD, Jiao Li MD, Juan Wang PhD, Xia Li PhD
The present study was conducted to measure the expression of early growth response factor 3 (Egr3), inflammatory cytokines (IL-1β, IL-6), vascular endothelial growth factor (VEGF) and NF-κB in patients with coronary artery disease (CAD) to investigate the relationships of these molecules and Egr3 gene expression. We recruited 132 CAD patients and 63 healthy individuals. The expression levels of Egr3
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Diabetes with GLP-1R polymorphism (rs3765467) accompanied by myotonic dystrophy: A case of myotonic dystrophy with p.R131Q polymorphism at the glucagon-like peptide-1 receptor (rs3765467) resulting in marked effects of its agonist, dulaglutide Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-08 Kanako Kato MD, Teruo Jojima MD PhD, Takahiko Kogai MD, Dai Tanuma MD, Takafumi Niitani MD, Shintaro Sakurai MD PhD, Toshie Iijima MD, Takuya Tomaru MD PhD, Isao Usui MD PhD, Yoshimasa Aso MD PhD
A 47-year-old woman was diagnosed with myotonic dystrophy when admitted for traumatic subarachnoid hemorrhage. Her glycemic control was poor despite administration of pioglitazone, a PPARɤ agonist, and subcutaneous insulin infusion. However, adding a GLP-1 receptor (GLP-1R) agonist markedly improved blood glucose levels, resulting in eventual insulin withdrawal. Genetic testing revealed a heterozygous
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Associations between serum uric acid and breast cancer incidence: A systematic review and meta-analysis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-08 Xiao Xue MM, Zhengyi Sun BM, Xufeng Ji MM, Hua Lin MM, Huang Jing MD, Qiuyang Yu MM
Serum uric acid (SUA) may be involved in the development of cancer by inhibiting oxidative stress, but its relationship with breast cancer remains unclear. The PubMed, Embase, and Web of Science databases were searched systematically for studies on SUA levels in women with breast cancer and the effect of SUA levels on the risk of breast cancer. The Newcastle‒Ottawa Quality Assessment Scale (NOS) was
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Efficacy and safety of the combination or monotherapy with GLP-1 receptor agonists and SGLT-2 inhibitors in Type 2 diabetes mellitus: An update systematic review and meta-analysis Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-06 Adili Tuersun MA, Guanxin Hou BA, Gang Cheng PhD
To evaluate the efficacy and safety of combination therapy with sodium-glucose cotransporter2(SGLT-2) inhibitors and glucagon-like peptide-1(GLP-1) receptor agonists in the treatment of type 2 diabetes mellitus (T2DM). To construct an exhaustive database of randomized controlled trials (RCTs) concerning SGLT-2 inhibitors and GLP-1 agonists, a methodical search was undertaken across a range of databases
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LncRNA CYTOR knockdown inhibits tumor development via regulating miR-503-5p/PCSK9 in lung adenocarcinoma Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-06 Zheng Zhu PhD, Jiawei Lu MD, Jichun Tong MD, Yajun Yin MD, Ke Zhang PhD
The intricate biological mechanism underlying lung adenocarcinoma (LUAD), characterized by a deficiency of distinctive biomarkers, remain elusive. The presence of Long non-coding RNAs (lncRNAs) have been established to play a role in carcinogenesis. Nevertheless, the regulatory effects and mechanisms of lncRNA CYTOR in LUAD have yet to be elucidated. In this study, RT-qPCR and Western blot were adopted
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Expanding pulmonary artery pressure monitoring to racially and socially diverse populations: A pilot CardioMEMS program Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-06 Ludwine D. Paul MSN ACNP-BC AACC, Sheikh Moinul MD, Manuel Urina-Jassir MD, Deepa M. Gopal MD MS, Nir Ayalon MD
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ACEI/ARB use within one year of kidney transplant is associated with less AKI and graft loss in elderly recipients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-05 A. Daoud MD, K. Soliman MD PhD, D. Rodriguez MD, P. Amaechi MD, T. Fulop MD, D. Taber PharmD, MA Posadas Salas MD
Optimizing long-term graft survival remains a major focus in transplant. Elderly kidney transplant recipients are vulnerable to acute kidney injury (AKI) and graft loss. This study assessed the safety and efficacy of ACEI/ARB in elderly kidney transplant recipients and impact on graft outcomes. Retrospective, longitudinal, cohort study of 500 patients age ≥60 years, who underwent kidney transplantation
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Long-term trends in lifestyle factors among respondents with dyslipidemia in the United States Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-05 Bingqing Bai MM, Quanjun Liu MM, Yuting Liu MD, Fengyao Liu MM, Yu Wang MD, Yilin Chen MM, Yanting Liang MM, Haochen Wang MM, Chao Wu PhD, Lan Guo PhD, Huan Ma PhD, Qingshan Geng PhD
To explore the long-term trends in unhealthy lifestyle factors and the risk sociodemographic subgroups among people with dyslipidemia. Data extracted from the 1999 to 2018 National Health and Nutrition Examination Survey (NHANES). Lifestyle factors were smoking status, alcohol drinking, obesity, dietary quality, depression, physical activity, and sedentary behavior. A Joinpoint regression model was
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Gut barrier dysfunction, endotoxemia and inflammatory response in STEMI patients and effect of primary PCI Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-04 Ioanna Oikonomou MD, Angeliki Papageorgiou MD, Anne-Lise de Lastic MD PhD, Athanasios Moulias MD PhD, Georgia-Andriana Georgopoulou MD, Athanasia Mouzaki MD PhD, Eleni-Evangelia Koufou MD, Grigorios Tsigkas MD PhD, Charalambos Gogos MD PhD, Periklis Davlouros MD PhD, Stelios F. Assimakopoulos MD PhD
Gut-derived bacterial and endotoxin translocation induce systemic inflammation, which exerts a pivotal pathogenetic role in all phases of atherosclerosis. To investigate prospectively the gut barrier function, endotoxin translocation and inflammatory response in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary artery intervention (PPCI). Twenty-seven patients
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Single nucleotide polymorphisms of GEMIN3 modify the risk of primary Sjögren's syndrome in female patients Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-04 Dong Wang PhD, Jingjing Zhang MD, Yufei Zhao MD, Ruijie Cao MD, Yingnan Wang MD, Iren Guo Student, Chenxing Peng PhD, Yanrong Song MD, Shasha Zhang MD
MicroRNA (miRNA)-processing machinery may modify the risk of primary Sjögren's syndrome (pSS) by altering miRNA expression profiles. Inflammatory cytokines and reactive oxygen species (ROS) are also involved in pSS; however, the role of altered miRNAs expression in its pathogenesis is still unclear. We aimed to evaluate the relationship between single-nucleotide polymorphisms (SNPs) in miRNA processing
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2024 SSCI Founders’ Medal Presentation and acceptance: Dr. Don Rockey Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-04 Jesse Roman MD, Don C. Rockey MD
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Pamiparib, a novel intervention with anti-neoplastic activity for the treatment of glioblastoma Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-03 Sehar Ul Duaa MBBS, Eeshal Fatima MBBS, Zaheer Qureshi MD
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Ethical consumption of antimicrobial agents: A proposal for a new concept in promoting antimicrobial stewardship Am. J. Med. Sci. (IF 2.3) Pub Date : 2024-07-03 Hideharu Hagiya MD PhD