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Psoriasiform drug eruption: A case series with a review of the literature Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-15 Miho Mori, Hiroshi Kawakami, Rie Tobita, Takashi Arai, Atsuko Satsuma, Ryoji Tsuboi, Yukari Okubo
The present case series examined five instances of psoriasiform drug eruption diagnosed between 2014 and 2022 at the study site and 23 cases of drug eruption manifesting psoriasiform lesions which had been reported between 1986 and 2022. The causative drug, distribution of the skin eruptions, clinical latency to eruption, treatment course, and histopathological findings were investigated. The most
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Possibility of maintaining remission with topical therapy alone after withdrawal of dupilumab in Japanese patients with atopic dermatitis and their characteristics in the real world Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-15 Ayu Watanabe, Masahiro Kamata, Yoshiki Okada, Shoya Suzuki, Makoto Ito, Hideaki Uchida, Chika Chijiwa, Shota Egawa, Azusa Hiura, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Yayoi Tada
Psossibility and appropriate timing of discontinuation of dupilumab for atopic dermatitis (AD) remain unclear. We explored the possibility of patients, who could maintain remission with topical therapy alone after withdrawing dupilumab in the real world. Furthermore, we identified their characteristics. All adult AD patients who initiated dupilumab from June 2018 to July 2022 and were treated with
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Predictive value of disease activity signs in vitiligo: An observational study Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-09 Liesbeth Delbaere, Jolien Duponselle, Sandrine Herbelet, Reinhart Speeckaert, Nanja van Geel
The progression of vitiligo is unpredictable, emphasizing the need to identify periods of activity early for tailored treatment. Confetti‐like depigmentation, hypochromic areas/borders and Koebner's phenomenon are clinical visible signs associated with disease activity in vitiligo. However, their true clinical significance requires further investigation using standardized scoring systems. In the present
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Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris—A retrospective study Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-09 Shuqiong You, Jianting Ouyang, Qian Wu, Yaozhong Zhang, Jian Gao, Xiaojia Luo, Yuan Wang, Yongzhuo Wu, Fuqiong Jiang
In this study, we aimed to examine the relationship between the serum cytokine levels of patients with pemphigus vulgaris (PV) and the Pemphigus Disease Area Index (PDAI), along with the presence of anti‐desmoglein (Dsg) 1 antibody, anti‐Dsg3 antibody and co‐infection among patients with pemphigus vulgaris. This retrospective study included 62 PV patients and 59 healthy individuals who attended the
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Causal effects of lipid‐lowering drugs on inflammatory skin diseases: Evidence from drug target Mendelian randomisation Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-04 Chenyang Zang, Jiaxin Li, Ying Zhang, Wenyu Deng, Manyun Mao, Wu Zhu, Wangqing Chen
Clinical research has revealed that inflammatory skin diseases are associated with dyslipidaemia. Modulating lipids is also a rising potential treatment option. However, there is heterogeneity in the existing evidence and a lack of large‐scale clinical trials. Observational research is prone to bias, making it difficult to determine causality. This study aimed to evaluate the causal association between
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Evaluation of Sézary cell marker expression and cell death behaviour upon in vitro treatment by flow cytometry in Sézary syndrome patients Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-02 S. Melchers, M. Roemer, J. D. Albrecht, C. Assaf, C. von Gugelberg, E. Guenova, C.‐D. Klemke, R. K. C. Moritz, M. Schlaak, R. Stadler, U. Wehkamp, M. Wobser, T. Albrecht, S. Goerdt, S. Schneider, J. P. Nicolay
The diagnosis of Sézary syndrome (SS) relies on the identification of blood Sézary cells (SC) by different markers via flow cytometry. Treatment of SS is challenging since its pathogenesis is characterized by cell death resistance rather than hyperproliferation. In this study, we establish an integrated approach that considers both the expression of SC markers and sensitivity to cell death both spontaneously
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Granzyme B inhibition reduces autoantibody‐induced dermal–epidermal separation in an ex vivo model of epidermolysis bullosa acquisita Exp. Dermatol. (IF 3.5) Pub Date : 2024-09-02 Shirin Emtenani, Hélène Lebhar, Christopher P. Marquis, Ralf J. Ludwig, Enno Schmidt
The pemphigoid disease epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies against type VII collagen (COL7), immune cell infiltrates at the dermal–epidermal junction and subepidermal blistering. Proteases, particularly granzyme B (GzmB), have been established as therapeutic targets for the treatment of EBA and other pemphigoid diseases. We
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Exploration of potential biomarkers for prurigo nodularis based on plasma‐metabolome analysis Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-29 Duoqin Wang, Lisi Peng, Yiqi Zhu, Shuwen Xu, Zijing Xiao, Yanyun Shen, Taiyu Jin, Yixin Shao, Hui Tang
Prurigo nodularis (PN) is a chronic and debilitating skin disease with severe itching that negatively impacts patients' quality of life and mental state. However, the treatment options for PN remain limited. Global metabolomics analysis can offer effective information on energy metabolism, pathogenesis and potential diagnostic biomarkers. No study on metabolomic analysis of PN has been reported. To
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Treatment of malignant melanoma with coxsackievirus A21 (V937): An emerging oncolytic virotherapy Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-29 Goranit Sakunchotpanit, Mihir K. Patil, Kaushik Venkatesh, Thomas Z. Rohan, Debby Cheng, Vinod E. Nambudiri
Despite rising melanoma incidence in recent decades, there is a trend towards overall decreased mortality, reflecting multiple factors including improved treatment options for metastatic disease. While local treatments are the mainstay for early‐stage melanoma, metastatic disease necessitates systemic treatment, with oncolytic virotherapy emerging as a promising option. For this review, articles were
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Combining dipyridamole and cilostazol with up‐dosing antihistamines improves outcomes in chronic spontaneous urticaria with high D‐dimer levels: A randomized controlled trial Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-23 Amornrat Prasertcharoensuk, Yuda Chongpison, Pattarawat Thantiworasit, Supranee Buranapraditkun, Pawinee Rerknimitr, Pungjai Mongkolpathumrat, Sirinoot Palapinyo, Hiroshi Chantaphakul, Pitiphong Kijrattanakul, Jettanong Klaewsongkram
In a double‐blind, randomized controlled trial, we investigated the effectiveness of adding antiplatelet drugs to up‐dosing antihistamines for the treatment of chronic spontaneous urticaria (CSU) in patients with elevated D‐dimer levels who had an inadequate response to conventional antihistamine doses. Twenty patients with Urticaria Activity Score over 7 days (UAS7) ≥16 and D‐dimer >500 ng/mL were
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The amino acid transporter SLC16A10 promotes melanogenesis by facilitating the transportation of phenylalanine Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-22 Liping Luo, Hongliang Zeng, Yibo Hu, Ling Jiang, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng
Phenylalanine is a crucial amino acid in the process of melanogenesis. However, the exact mechanism by which it is transported into melanocytes has not been disclosed. The aim of this study was to identify and examine the key transporters that are responsible for phenylalanine transportation and evaluate their significance in melanogenesis. The amino acid transporter SLC16A10 was found to be up‐regulated
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Polycyclic aromatic hydrocarbons exposure associated with increased risk of psoriasis Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-22 Shu Zhou, Li Lei, Ling Jiang, Chuhan Fu, Yaqing Wen, Jiangfeng Huang, Keyi Zhang, Jinhua Huang, Jing Chen, Qinghai Zeng
Psoriasis is considered to be multifactorial, with both genetic and environmental factors contributing to its development. Polycyclic aromatic hydrocarbons (PAHs) are widespread in the environment, originating from sources such as cigarette smoke, exhaust emissions, grilled foods, smoked foods and urban air. Researchs have established a link between PAHs exposure and autoimmune disorders; however,
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Skin inflammatory signatures, as measured by disordered spatial redness patterns, predict current and future skin ageing attributes Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-22 Tatsuya Omotezako, Wenzhu Zhao, MyriamRubecca Rodrigues, Matthew Ehrman, Denny Deng, HiuFung Lau, Tomohiro Hakozaki
Facial skin redness can be an indicator of skin inflammation, however the physiological connection between facial redness and inflammatory status, as well as its role in age‐related skin changes, remains poorly understood. This study aims to investigate the association between the pattern of facial skin redness and biological inflammatory status, as well as age‐related changes occurring in the skin
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Meta‐analysis reveals a lower ‘UV signature’ in vitiligo skin compared to non‐melanoma skin cancers Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-22 Apeksha Yadav, Nida Parveen, Namratha Puttur, Aayush Gupta, Archana Singh
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Comorbidities associated with discoid lupus erythematosus: A case–control study in the All of Us Research Program Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-21 Mihir K. Patil, Carlos E. Salazar, Krithika Nayudu, Thomas Z. Rohan, Vinod E. Nambudiri
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Metabolic profiling of psoriasis vulgaris and palmoplantar pustulosis Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-21 Yujin Lee, Seong Rae Kim, Mu Seong Ban, Howard Lee, Joo‐Youn Cho, Seong Jin Jo
Psoriasis is a chronic inflammatory skin disorder with various subtypes, including psoriasis vulgaris (PV) and palmoplantar pustulosis (PPP). Metabolomics studies have provided insights into psoriasis pathogenesis. However, research on metabolomic alterations in PV and PPP patients is limited. We aimed to explore and compare the metabolic profiles of patients with PV and PPP to those of healthy volunteers
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Dynamic optical coherence tomography unveils subclinical, vascular differences across actinic keratosis grades I–III Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-14 Gabriella Fredman, Christine Sofie Krohn Fuchs, Emily Wenande, Peter A. Philipsen, Gavrielle R. Untracht, Flemming Andersen, Peter Bjerring, Stine R. Wiegell, Merete Haedersdal
Actinic keratosis (AK) classification relies on clinical characteristics limited to the skin's surface. Incorporating sub‐surface evaluation may improve the link between clinical classification and the underlying pathology. We aimed to apply dynamic optical coherence tomography (D‐OCT) to characterize microvessels in AK I‐III and photodamaged (PD) skin, thereby exploring its utility in enhancing clinical
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Irisin promotes hair growth and hair cycle transition by activating the GSK‐3β/β‐catenin pathway Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-12 Yujin Kim, Jung Min Lee, You Na Jang, A. Yeon Park, Su‐Young Kim, Beom Joon Kim, Jung Ok Lee
Hair loss affects men and women of all ages. Myokines, which are mainly secreted by skeletal muscles during exercise, have numerous health benefits. VEGF, IGF‐1, FGF and irisin are reprehensive myokines. Although VEGF, IGF‐1 and FGF are positively associated with hair growth, few studies have researched the effects of irisin on hair growth. Here, we investigated whether irisin promotes hair growth
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Sulfuric acid‐induced skin neoplasms in immunocompetent mice Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-12 Oumaima Chgari, Farida Marnissi, Fatimazahra Moukhfi, Martin Ndayambaje, Hicham Wahnou, Youness Limami, Mehdi Karkouri, Mounia Oudghiri
This study investigates the carcinogenic potential of chronic dermal exposure (16 weeks) to sulfuric acid (SA) in immunocompetent mice. Clinical assessments, histopathological analyses, immunohistochemical analyses and biochemical assays were conducted to evaluate skin irritation, oxidative stress biomarkers and the potential carcinogenic effect of SA. Results indicated that prolonged exposure to SA
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Pro‐inflammatory activity of Cutibacterium acnes phylotype IA1 and extracellular vesicles: An in vitro study Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-08 Caroline T. Cheung, Ugo Lancien, Stéphane Corvec, Valérie Mengeaud, Céline Mias, Joëlle Véziers, Amir Khammari, Brigitte Dréno
Acne is a chronic inflammatory skin condition that involves Cutibacterium acnes (C. acnes), which is classified into six main phylotypes (IA1, IA2, IB, IC, II and III). Acne development is associated with loss of C. acnes phylotype diversity, characterised by overgrowth of phylotype IA1 relative to other phylotypes. It was also shown that purified extracellular vesicles (EVs) secreted by C. acnes can
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An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-08 Warda Abdi, Andrew Romasco, Dany Alkurdi, Elise Santacruz, Isabel Okinedo, Yuying Zhang, Shriya Kannan, Saeed Shakiba, Jillian M. Richmond
S100 proteins comprise a family of structurally related proteins that are calcium‐sensitive. S100 proteins have been found to play various roles in regulation of cell apoptosis, cell proliferation and differentiation, cell migration and invasion, energy metabolism, calcium homeostasis, protein phosphorylation, anti‐microbial activity and inflammation in a variety of cell types. While the specific function
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Histone modification in psoriasis: Molecular mechanisms and potential therapeutic targets Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-02 Ruifeng Liu, Luyao Zhang, Kaiming Zhang
Psoriasis is an immune‐mediated, inflammatory disease. Genetic and environmental elements are involved in the nosogenesis of this illness. Epigenetic inheritance serves as the connection between genetic and environmental factors. Histone modification, an epigenetic regulatory mechanism, is implicated in the development of numerous diseases. The basic function of histone modification is to regulate
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Cover Image Exp. Dermatol. (IF 3.5) Pub Date : 2024-08-01 Yingrou Tan, Yuning Zhang, Jackson Liang Yao Li, Hui Yi Chia, Melissa Wee Ping Tan, Gernot Ebel, Keith Weng Kit Leong, Eiffer Ying Qi Lim, Kylia Kai Ling Chong, Bernett Teck Kwong Lee, Lai Guan Ng, Hong Liang Tey
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Genetic polymorphisms to identify patients with an optimal response to tildrakizumab in psoriasis patients from real‐life clinical practice Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-31 B. Butrón‐Bris, M. Llamas‐Velasco, M. C. Ovejero‐Benito, J. Santos‐Juanes, A. Martínez‐López, R. Ruiz‐Villaverde, G. Roustan, O. Baniandrés, R. Izu‐Belloso, P. de la Cueva, A. Sahuquillo‐Torralba, A. Gónzalez‐Quesada, E. Vilarrasa‐Rull, J. Pujol‐Montcusí, J. García‐Martínez, M. Navares, I. Palomar‐Moreno, J. Novalbos, F. Abad‐Santos, E. Daudén, H. de la Fuente
Detecting the association of genetic variants to the response of biological therapy represents an important advance in developing a personalized therapy. The aim of this work was to study the association of polymorphisms with an optimal response to tildrakizumab in patients with psoriasis in a real‐life clinical practice. Ninety patients with plaque psoriasis recruited from—Spanish hospitals receiving
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Cellular and molecular landscape of primary dermatofibrosarcoma protuberans: Insights from single‐cell RNA sequencing analysis Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-31 Rui Peng, Yingyi Li, Yumei Gao, Dian Chen, Zhenghui Li, Yi Zhao
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma characterized by the COL1A1‐PDGFB fusion gene. This study utilized single‐cell RNA sequencing to dissect the cellular and molecular landscape of primary DFSP. Distinct DFSP cell clusters, exhibiting fibroblast‐like traits, revealed variations in pathways associated with proliferation, inflammation and metabolism. Differential gene expression
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Simple tape‐stripping method for highly reliable and quantitative analysis of skin microbiome Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-31 Naoki Soga, Risa Nagura, Risa Nakamura, Katsunori Kohda, Yumi Motoyama, Masakazu Ito, Ichiro Nakagawa, Saeko Nakajima, Akinori Ikeuchi
The composition of human skin microbiome profoundly impacts host skin health and disease. However, the relationship between skin homeostasis or the development of skin diseases and daily changes in skin microbial composition is poorly understood. Longitudinal samplings at more frequent intervals would address this issue, while conventional sampling methods have technical difficulties, leading to limitations
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Unveiling the value of C‐reactive protein as a severity biomarker and the IL4/IL13 pathway as a therapeutic target in recessive dystrophic epidermolysis bullosa: A multiparametric cross‐sectional study Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-30 Lucía Quintana‐Castanedo, Silvia Sánchez‐Ramón, Rocío Maseda, Nuria Illera, Isabel Pérez‐Conde, Marta Molero‐Luis, Nora Butta, Elena G. Arias‐Salgado, Elena Monzón‐Manzano, Pilar Zuluaga, Lucía Martínez‐Santamaría, Miguel Fernández‐Arquero, Sara G. Llames, Álvaro Meana, Raúl de Lucas, Marcela del Río, Ángeles Vicente, María José Escámez, Rosa Sacedón
Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and infection. Understanding the immunological mechanisms is crucial for selecting medications that balance inflammation control and immunocompetence. In this cross‐sectional study, aiming to identify potential immunotherapeutic targets and inflammatory
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Wound area severity index (WASI): A novel tool for assessing and predicting healing times in hidradenitis suppurativa postsurgical wounds Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-30 Alessandra Michelucci, Flavia Manzo Margiotta, Silvia Innocenti, Antonella Vietina, Giammarco Granieri, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini
Hidradenitis suppurativa (HS) presents challenges in management due to its chronic nature and high risk of recurrence. Post‐surgical wound care plays a crucial role in treatment, even if standardized methods for assessing and predicting healing times are lacking. The aim of the study is to introduce the Wound Area Severity Index (WASI) as a novel tool to guide clinicians in assessing postsurgical wound
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Loss of keratin 14 expression from immortalized keratinocytes by promoter methylation Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-29 Rosita Koh, Ildiko Szeverenyi, Declan P. Lunny, Goi Hui Eng, E. Birgitte Lane
Immortalized keratinocytes can offer a low‐cost experimental platform for human skin research, with increased cell yield compared to primary cultures. However, the usefulness of these surrogate cell models is highly dependent on their ability to retain the phenotypic attributes of the parent cells. Keratins K14 and K5 are the hallmarks of undifferentiated, mitotically active basal keratinocytes. We
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Leveraging single‐cell sequencing analysis and bulk‐RNA sequencing analysis to forecast necroptosis in cutaneous melanoma prognosis Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-25 Jiaheng Xie, Pengpeng Zhang, Qikai Tang, Chenfeng Ma, Muyang Li, Min Qi
Cutaneous melanoma, a malignancy of melanocytes, presents a significant challenge due to its aggressive nature and rising global incidence. Despite advancements in treatment, the variability in patient responses underscores the need for further research into novel therapeutic targets, including the role of programmed cell death pathways such as necroptosis. The melanoma datasets used for analysis,
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Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-24 Jiangtao Cui, Shiyi Zhang, Kiran Acharya, Yan Xu, Heng Guo, Tong Li, Donghe Fu, Zizhen Yang, Lingnan Hou, Xiaotao Xing, Xiaoyi Hu
The management of hypertrophic scars (HSs), characterized by excessive collagen production, involves various nonsurgical and surgical interventions. However, the absence of a well‐defined molecular mechanism governing hypertrophic scarring has led to less‐than‐ideal results in clinical antifibrotic treatments. Therefore, our study focused on the role of decorin (DCN) and its regulatory role in the
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Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high‐dose dietary zinc as a therapeutic agent Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-24 Li Li, Irshad Hajam, Jean S. McGee, Zhengkuan Tang, Ye Zhang, Nikil Badey, Esther Mintzer, Zhenrui Zhang, George Y. Liu, George M. Church, Yu Wang
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular
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Melanoma and cannabinoids: A possible chance for cancer treatment Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-23 Mariarosaria Galeano, Federico Vaccaro, Natasha Irrera, Emanuela Caradonna, Francesco Borgia, Federica Li Pomi, Francesco Squadrito, Mario Vaccaro
The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by exogenous compounds, such as those derived from the Cannabis sativa. Cannabis and its bioactive compounds, including cannabinoids and non‐cannabinoids, have been extensively studied in different conditions
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Metabolomic profiling and accurate diagnosis of basal cell carcinoma by MALDI imaging and machine learning Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-22 Lauritz F. Brorsen, James S. McKenzie, Fernanda E. Pinto, Martin Glud, Harald S. Hansen, Merete Haedersdal, Zoltan Takats, Christian Janfelt, Catharina M. Lerche
Basal cell carcinoma (BCC), the most common keratinocyte cancer, presents a substantial public health challenge due to its high prevalence. Traditional diagnostic methods, which rely on visual examination and histopathological analysis, do not include metabolomic data. This exploratory study aims to molecularly characterize BCC and diagnose tumour tissue by applying matrix‐assisted laser desorption
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Anti‐IL17 Secukinumab in hidradenitis suppurativa: A long‐term drug survival analysis Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-20 Gabriele Roccuzzo, Federica Repetto, Silvia Giordano, Cristina Sarda, Arianna Comes, Paolo Dapavo, Pietro Quaglino, Simone Ribero
Real‐world data on the long‐term effectiveness of the anti‐IL17 agent secukinumab in treating moderate‐to‐severe Hidradenitis suppurativa (HS) are lacking. In this study, 24 patients with moderate–severe HS received five weekly subcutaneous injections followed by maintenance doses every 4 weeks. Primary outcomes included HiSCR, IHS4 reduction, and DLQI measures assessed at 12‐week intervals. The median
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The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-20 Shiying Lin, Xin Liu, Jian Jiang, Wenqiang Ge, Yinlian Zhang, Fei Li, Qingxiao Tao, Suwen Liu, Man Li, Hongxiang Chen
Frequent itching and incessant scratching are commonly observed in various chronic inflammatory skin conditions, including atopic dermatitis and psoriasis. The persistent and prolonged nature of pruritus can worsen one's quality of life. Keratinocytes (KCs), the predominant cells of the epidermis, have been confirmed to interact with sensory neurons and immune cells and be involved in chronic skin
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AP collagen peptides (APCPs) promote hair growth by activating the GSK‐3β/β‐catenin pathway and improve hair condition Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-19 Jung Ok Lee, Yujin Kim, Jung Min Lee, Jang Mi Suk, Inhee Jung, Sun Young Choi, Kwang Ho Yoo, Joon Seok, Beom Joon Kim
AP collagen peptides (APCPs) are enzymatically decomposed collagen peptides that contain tri‐peptides such as glycine‐proline‐hydroxyproline. We found that APCPs increased the proliferation of both human dermal papilla cells (hDPCs) and human outer root sheath cells (hORSCs). APCPs also stimulated the secretion of several growth factors, including IGFBP‐6, PDGF‐AB, PIGF and VEGF in hDPCs. Moreover
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Pyroptosis and its role in autoimmune skin disease Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-18 Yuanjun Yao, Zehong Wang, Junqin Li, Aihong Peng, Yue Cao, Nannan Liang, Kaiming Zhang
Autoimmune skin disease is a kind of heterogeneous disease with complicated pathogenesis. Many factors such as genetic, infectious, environmental and even psychological factors may interact together to trigger a synergistic effect for the development of abnormal innate and adaptive immune responses. Although the exact mechanisms remain unclear, recent evidence suggests that pyroptosis plays a pivotal
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Correction to ‘Dose escalation of biologic treatment in patients with moderate‐to‐severe psoriasis in Japan’ Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-17
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Melanin accumulation in acanthotic seborrheic keratosis: Reduced proliferation and early differentiation of keratinocytes and increased number of melanocytes Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-15 Mizuki Ueno, Yu Gabe, Megumi Tobiishi, Aya Komiya, Takuo Yuki, Keigo Kawabata, Yoshito Takahashi, Tamio Suzuki
Seborrheic keratosis (SK) is a common benign tumour, often associated with hyperpigmentation. To investigate the mechanism of melanin accumulation in SK, we have conducted comprehensive gene expression and histological analyses. We obtained five pairs of skin samples, including non‐lesional and SK samples, from the backs of three male Japanese participants aged 40–59 years. To examine melanocytes and
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Topical use of tobramycin: A possible innovative treatment of severe skin chronic ulcers Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-15 Corrado Cirielli, Francesco Facchiano, Mauro Picardo, Marco Benedetto, Roberto Tagliaferri, Stefano Tagliaferri, Giuseppe Piccinni, Annarita Panebianco, Antonio Facchiano
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Increased loss‐of‐function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta‐analysis Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-11 Casper Milde Khatib, Amalie Wandel Klein‐Petersen, Amalie Thorsti Møller Rønnstad, Alexander Egeberg, Maria Oberländer Christensen, Jonathan Ian Silverberg, Simon Francis Thomsen, Alan David Irvine, Jacob Pontoppidan Thyssen
Loss‐of‐function (LoF) mutations in the filaggrin gene (FLG) constitute the strongest genetic risk for atopic dermatitis (AD). A latitude‐dependent difference in the prevalence of LoF FLG mutations was systematically evaluated. A systematic review and meta‐analysis were performed to estimate the prevalence of LoF FLG mutations in AD patients and the general population by geography and ethnicity. Risk
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Eosinophils in hidradenitis suppurativa patients exhibit pro‐inflammatory traits, implicating a potential pathogenic role in the disease Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-10 Yael Renert‐Yuval, Juana Gonzalez, Sandra Garcet, Samuel C. Williams, Ariana Moreno, James G. Krueger
Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful nodules, abscesses and purulent secretions in intertriginous regions. Intense pruritus frequently accompanies HS lesions, adding further discomfort for patients. While Th17 pathway activation is implicated in HS pathogenesis, disease mechanisms are still not fully understood, and therapeutics are lacking. Previous
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Analysis of risk factors related to chronic non‐healing wound infection and the construction of a clinical prediction model Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-08 Jing Liu, Qiang He, Gaijuan Guo, Chunbao Zhai
This study is aimed to analyse the risk factors associated with chronic non‐healing wound infections, establish a clinical prediction model, and validate its performance. Clinical data were retrospectively collected from 260 patients with chronic non‐healing wounds treated in the plastic surgery ward of Shanxi Provincial People's Hospital between January 2022 and December 2023 who met the inclusion
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Metabolic dynamics in psoriatic epidermis: Enhanced glucose and lactate uptake, glycolytic pathway and TCA cycle dynamics Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-08 Satoshi Nakamizo, Hiromi Doi, Kenji Kabashima
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Spinal histamine H4 receptor mediates chronic pruritus via p‐ERK in acetone–ether–water (AEW)‐induced dry skin mice Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-08 Ting‐Ting Wang, Zi‐Yang Li, Dan‐Dan Hu, Xian‐Yun Xu, Ning‐Jing Song, Gang‐Qiang Li, Ling Zhang
Dry skin is common to many pruritic diseases and is difficult to improve with oral traditional antihistamines. Recently, increasing evidence indicated that histamine H4 receptor (H4R) plays an important role in the occurrence and development of pruritus. Extracellular signal‐regulated kinase (ERK) phosphorylation activation in the spinal cord mediates histamine‐induced acute and choric itch. However
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Pulmonary interstitial lesions in pemphigus mouse model: Verifying pemphigus may not be only limited to skin and mucosa Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-08 Chang Tang, Lanting Wang, Qingmei Liu, Zihua Chen, Jin Yang, Haiqing Gao, Chenggong Guan, Shan He, Luyao Zhang, Shenyuan Zheng, Fanping Yang, Shengan Chen, Li Ma, Zhen Zhang, Ying Zhao, Jiucun Wang, Xiaoqun Luo
Interstitial lung disease (ILD) has been identified as a prevalent complication and significant contributor to mortality in individuals with pemphigus. In this study, a murine model of pemphigus was developed through the subcutaneous administration of serum IgG obtained from pemphigus patients, allowing for an investigation into the association between pemphigus and ILD. Pulmonary interstitial lesions
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Decreased serum IL‐38 levels in pemphigus vulgaris Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-04 Toyoki Yamamoto, Lixin Li, Yukiko Ito, Shinichi Sato, Sayaka Shibata
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Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease Exp. Dermatol. (IF 3.5) Pub Date : 2024-07-01 Jonathan Tegtmeyer, Maurizio Romagnuolo, Christoph M. Hammers, Bianca Opelka, Christian Probst, Lars Komorowski, Angelo V. Marzano, Enno Schmidt, Stephanie Goletz
The 16th non‐collagenous domain (NC16A) of BP180 is the main antigenic target of autoantibodies in bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP). Commercially available assays detect serum autoantibodies against NC16A in the majority of BP (80%–90%) and in approximately 50% of MMP patients. However, a standardized test system for detecting antibodies against other regions of BP180 is
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Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-24 Paul L. Bigliardi, Sydney Lo, Elena Bigliardi, Yuri Dancik, Emmanuelle Leblanc‐Noblesse, Mei Bigliardi‐Qi
While the evidence for the implication of opioid receptors (OPr) in ageing is growing, there is, to our knowledge, no study focusing directly on changes in vivo cutaneous OPr expression with increasing age. We thus investigated OPr expression in 30 healthy female Asian volunteers in Southern China whose ages range from the early 20s to the early 60s. Excisional biopsies were taken from the sun‐exposed
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Deciphering dermatological distinctions: Cornulin as a discriminant biomarker between basal cell carcinoma and squamous cell carcinoma detected through e‐biopsy and machine learning Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-22 Edward Vitkin, Julia Wise, Ariel Berl, Ofir Shir‐az, Vladimir Kravtsov, Zohar Yakhini, Avshalom Shalom, Alexander Golberg
Clinical misdiagnosis between cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) poses treatment challenges and carries risks of recurrence, metastases and increased morbidity and mortality. We aimed to identify discriminant proteins markers for cSCC and BCC using a minimally invasive proteome sampling method called e‐biopsy, employing electroporation for non‐thermal cell permeabilization
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Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-22 Olivia Luxford Meyer, Jeppe Dyrberg Andersen, Claus Børsting, Niels Morling, Mikkel Meyer Andersen, Hans Christian Wulf, Peter Alshede Philipsen, Catharina Margrethe Lerche
Squamous cell carcinoma (SCC) is a common skin cancer, often caused by exposure to ultraviolet radiation (UVR). Recent studies have shown that changes in DNA methylation play a crucial role in the development of cancers. However, methylation patterns of SCC are not well characterised. Identifying biomarkers for the risk of developing SCC could be helpful for early detection and diagnosis and can potentially
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A collagen biostimulator improves photoaging pigmentation Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-22 Jin Cheol Kim, Dong Chan Kim, Hyoung Soo Park, Suk Bae Seo, Hee Young Kang
Photoaging pigmentation conditions such as senile lentigo and melasma show epidermal melanogenic activity and dermal abnormalities, including collagen degradation. A dermal rejuvenation strategy with skin‐lightening therapy directly acting on melanocytes is suggested for photoaging pigmentation. This study investigates whether collagen biostimulation can result in skin lightening of photoaging skin
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miR-4521-A novel biomarker for human lentigos. Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-01 Hiroshi Maeno,Yoko Suzuki-Horiuchi,Ayaka Funakoshi,Onuma Chumsakul,Yasunari Sato,Tsuyoshi Ishii,John T Seykora
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IL-4 and IL-13 are not involved in IL-31-induced itch-associated scratching behaviour in mice. Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-01 Rana Kawai,Nao Ichimasu,Kazumoto Katagiri
Itchy skin or pruritus is a common cutaneous symptom that causes an urge to scratch, and the role of interleukins (IL) in itchy skin has been widely studied. IL-4 and IL-13 are known to induce chronic itch. Similarly, the direct role of IL-31 in inducing itch has been demonstrated in clinical situations such as atopic dermatitis and prurigo nodularis. Moreover, IL-4 receptor α antibodies (dupilumab)
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The novel prognostic marker SPOCK2 regulates tumour progression in melanoma. Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-01 Ji Young Kang,Hyeijin Cho,Minchan Gil,Haeryung Lee,Soochul Park,Kyung Eun Kim
Secreted protein acidic and cysteine rich/osteonectin, cwcv and kazal-like domain proteoglycan 2 (SPOCK2) is a protein that regulates cell differentiation and growth. Recent studies have reported that SPOCK2 plays important roles in the progression of various human cancers; however, the role of SPOCK2 in melanoma remains unknown. Therefore, this study investigated the roles of SPOCK2 and the related
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Integrated bioinformatics analysis and experimental validation identifies CPE as a potential biomarker and therapeutic target for skin aging. Exp. Dermatol. (IF 3.5) Pub Date : 2024-06-01 Xiaozhen Peng,Yun Zhong,Rui Mao,Fanping He,Yufan Cheng,Mengting Chen,Lei Zhou,Hongfu Xie,Ji Li,Yiya Zhang
Ageing is an inevitable biological process characterized by progressive decline in physiological functions. It is a complex natural phenomenon that will cause structural and functional decline. Despite substantial progress in understanding the mechanism of ageing, both predictive biomarkers and preventive therapies remain limited. Using Weighted Gene Co-expression Network Analysis (WGCNA) and machine