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An introduction to the adverse health impacts of inhaled toxicants in global marginalized communities Inhalation toxicology. (IF 2.0) Pub Date : 2024-07-21 Antonio F. Saporito, Judith T. Zelikoff
Published in Inhalation Toxicology: International Forum for Respiratory Research (Vol. 36, No. 5, 2024)
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Development of a risk prediction nomogram for delayed neuropsychiatric sequelae in patients with acute carbon monoxide poisoning Inhalation toxicology. (IF 2.0) Pub Date : 2024-07-10 Ghada N. El-Sarnagawy, Fatma M. Elgazzar, Mona M. Ghonem
Delayed neuropsychiatric sequelae (DNS) are critical complications following acute carbon monoxide (CO) poisoning that can substantially affect the patient’s life. Identifying high-risk patients fo...
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Evaluation of airborne asbestos concentrations associated with the maintenance of brakes on an industrial overhead crane Inhalation toxicology. (IF 2.0) Pub Date : 2024-07-02 Tyler Ferracini, Sarah Brown, Brooke Simmons, Heather Avens, Shannon Gaffney, Scott Dotson, Jennifer Sahmel
To evaluate potential airborne asbestos exposures during brake maintenance and repair activities on a P&H overhead crane, and during subsequent handling of the mechanic’s clothing.Personal (n = 27)...
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The fate of an inhaled cigarette puff in the human respiratory tract Inhalation toxicology. (IF 2.0) Pub Date : 2024-06-23 Bahman Asgharian, Owen Price, Scott Wasdo, Cissy Li, Kamau O. Peters, Ryan M. Haskins, Susan Chemerynski, Jeffry Schroeter
Cigarette smoking can lead to a host of adverse health effects such as lung and heart disease. Increased lung cancer risk is associated with inhalation of carcinogens present in a puff of smoke. Th...
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Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice via NF-κb-signaling pathway Inhalation toxicology. (IF 2.0) Pub Date : 2024-06-05 Tao-Lin Qing, Xuan-Yao Jiang, Jin-Feng Li, Qi Shen, Xin-Yi Zhao, Li-Jun Ren, Xiao-Yu Dai, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Bin Zhang, Lang Yan, Ji-Kuai Chen, Jiang-Bo Zhu
Multiwalled carbon nanotubes (MWCNTs) have numerous applications in the field of carbon nanomaterials. However, the associated toxicity concerns have increased significantly because of their widesp...
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Exposure to tungsten particles via inhalation triggers early toxicity marker expression in the rat brain Inhalation toxicology. (IF 2.0) Pub Date : 2024-06-05 Léo Macé, Chloé Brizais, Florence Bachelot, Annabelle Manoury, Sébastien Thomé, Céline Gloaguen, Imène Garali, Victor Magneron, Virginie Monceau, Amandine Sache, Frédéric Voyer, Christelle Elie, Laurence Roy, François Gensdarmes, Dmitry Klokov, Michelle L. Block, Chrystelle Ibanez
Our work is focused on tungsten, considered as an emerging contaminant. Its environmental dispersion is partly due to mining and military activities. Exposure scenario can also be occupational, in ...
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The effect of enriched versus depleted housing on eucalyptus smoke-induced cardiovascular dysfunction in mice Inhalation toxicology. (IF 2.0) Pub Date : 2024-05-22 Molly E. Harmon, Michelle Fiamingo, Sydnie Toler, Kaleb Lee, Yongho Kim, Brandi Martin, Ian Gilmour, Aimen K. Farraj, Mehdi S. Hazari
Objectives: Living conditions play a major role in health and well-being, particularly for the cardiovascular and pulmonary systems. Depleted housing contributes to impairment and development of di...
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MiR-421 mediates PM2.5-induced endothelial dysfunction via crosstalk between bronchial epithelial and endothelial cells Inhalation toxicology. (IF 2.0) Pub Date : 2024-05-22 Yiqing Chen, Mengting Zeng, Jinxin Xie, Zhihao Xiong, Yuxin Jin, Zihan Pan, Michail Spanos, Tianhui Wang, Hongyun Wang
PM2.5 is closely linked to vascular endothelial injury and has emerged as a major threat to human health. Our previous research indicated that exposure to PM2.5 induced an increased release of miR-...
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A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures Inhalation toxicology. (IF 2.0) Pub Date : 2024-05-20 Mary Buford, Sarah Lacher, Matthew Slattery, Daniel C. Levings, Britten Postma, Andrij Holian, Chris Migliaccio
Due to climate change, wildfires have increased in intensity and duration. While wildfires threaten lives directly, the smoke has more far-reaching adverse health impacts. During an extreme 2017 wi...
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The role of membrane transporters in the absorption of atrazine following nasal exposure Inhalation toxicology. (IF 2.0) Pub Date : 2024-05-13 Wisam Al Bakri, Maureen D. Donovan
The purpose of these studies was to investigate the uptake of atrazine across the nasal mucosa to determine whether direct transport to the brain through the olfactory epithelium is likely to occur...
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Sinomenine attenuates bleomycin-induced pulmonary fibrosis, inflammation, and oxidative stress by inhibiting TLR4/NLRP3/TGFβ signaling Inhalation toxicology. (IF 2.0) Pub Date : 2024-05-07 Yijue Liu, Hong Chen, Yan Wu, Fen Ai, Wei Li, Huan Peng, Feng Gui, Bo Yu, Zhen Chen
The present work concentrated on validating whether sinomenine alleviates bleomycin (BLM)-induced pulmonary fibrosis, inflammation, and oxidative stress.A rat model of pulmonary fibrosis was constr...
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Characterization of mass distribution in a biomimetic aerosol exposure system Inhalation toxicology. (IF 2.0) Pub Date : 2024-04-26 S. Emma Sarles, Edward C. Hensel, Caleb Nuss, Janessa Terry, Risa Robinson
Lack of biomimicry in geometry and flow conditions of emissions systems for analytical testing and biological exposure has led to fundamental limitations, including a poor understanding of dose del...
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Human health impacts attributable to inhalation exposure of particulate matter (PM10 and PM2.5) during the Holi festival Inhalation toxicology. (IF 2.0) Pub Date : 2024-04-26 Abhinandan Khajuria, Pallavi Saxena, Saurabh Sonwani, Anju Srivastava
The present study focuses on residential areas of Delhi to identify the elevated levels of ambient PM10 and PM2.5 due to biomass burning followed by the coloring activity in the Holi festival celeb...
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Traffic-related air pollution in marginalized neighborhoods: a community perspective Inhalation toxicology. (IF 2.0) Pub Date : 2024-04-15 Rahanna N. Khan, Antonio F. Saporito, Jania Zenon, Lael Goodman, Judith T. Zelikoff
Marginalized communities are exposed to higher levels of traffic-related air pollution (TRAP) than the general population. TRAP exposure is linked to pulmonary toxicity, neurotoxicity, and cardiova...
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The presence of erionite in North American geologies and the estimated mesothelioma potency by region Inhalation toxicology. (IF 2.0) Pub Date : 2024-04-07 Michael E. Stevens, Dennis J. Paustenbach, Noah J. Lockhart, Dalton E. Busboom, Blake M. Deckard, David W. Brew
Erionite is a naturally occurring fibrous mineral found in soils in some geographical regions. Known for its potency for causing mesothelioma in the Cappadocia region of Turkey, the erionite fiber ...
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Elongated particulate burden in an individual who died of mesothelioma and had an occupational history as a talc “mucker” Inhalation toxicology. (IF 2.0) Pub Date : 2024-03-19 Ronald F. Dodson, Jacqueline Moline, Carlos D. Salinas, Lee W. Poye
Tissue from a 77-year-old man diagnosed with mesothelioma was referred with a request for identification of the presence of fibrous structures in tissue samples. The individual’s work history inclu...
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Evaluation of neural reflex activation as a potential mode of action for respiratory and cardiovascular effects of fine particulate matter Inhalation toxicology. (IF 2.0) Pub Date : 2024-03-15 Robyn L. Prueitt, Cassandra J. Meakin, Nicholas L. Drury, Julie E. Goodman
Mortality from respiratory and cardiovascular health conditions contributes largely to the total mortality that has been associated with exposure to PM2.5 in epidemiology studies. A mode of action ...
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Crystalline silica-induced pulmonary inflammation and autoimmunity in mature adult NZBW/f1 mice: age-related sensitivity and impact of omega-3 fatty acid intervention Inhalation toxicology. (IF 2.0) Pub Date : 2024-03-13 Lauren K. Heine, Tasha Scarlett, James G. Wagner, Ryan P. Lewandowski, Abby D. Benninghoff, Ashleigh N. Tindle, Anna E. Skedel, Jack R. Harkema, James J. Pestka
Occupational exposure to respirable crystalline silica (cSiO2) has been linked to lupus development. Previous studies in young lupus-prone mice revealed that intranasal cSiO2 exposure triggered aut...
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Biological effects of diesel exhaust inhalation. III cardiovascular function Inhalation toxicology. (IF 2.0) Pub Date : 2024-03-11 Kristine Krajnak, Hong Kan, Janet A. Thompson, Walter McKinney, Stacey Waugh, Tim South, Dru Burns, Ryan Lebouf, Jared Cumpston, Theresa Boots, Jeffrey S. Fedan
Inhalation of diesel exhaust (DE) has been shown to be an occupational hazard in the transportation, mining, and gas and oil industries. DE also contributes to air pollution, and therefore, is a he...
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Short-term hyperoxia induced mitochondrial respiratory chain complexes dysfunction and oxidative stress in lung of rats Inhalation toxicology. (IF 2.0) Pub Date : 2024-03-06 Leonardo Tenfen, Richard Simon Machado, Khiany Mathias, Natalia Piacentini, Larissa Joaquim, Sandra Bonfante, Lucineia Gainski Danielski, Nicole Alessandra Engel, Mariella Reinol da Silva, Gislaine Tezza Rezin, Rafaella Willig de Quadros, Fernanda Frederico Gava, Fabricia Petronilho
Oxygen therapy is an alternative for many patients with hypoxemia. However, this practice can be dangerous as oxygen is closely associated with the development of oxidative stress.Male Wistar rats ...
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Lipid mediators of inhalation exposure-induced pulmonary toxicity and inflammation Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-29 Arjun Pitchai, Kimberly Buhman, Jonathan H. Shannahan
Many inhalation exposures induce pulmonary inflammation contributing to disease progression. Inflammatory processes are actively regulated via mediators including bioactive lipids. Bioactive lipids...
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Notoginsenoside R1 restrains the proliferation and migration of airway smooth muscle cells isolated from rats with chronic obstructive pulmonary disease Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-27 Xiaoyong Li, Kai Chen, Xuefei Shi, Shunli Dong, Yi Chen, Bin Wang
Chronic obstructive pulmonary disease (COPD) is a common disorder that is characterized by systemic and lung inflammation. Notoginsenoside R1 (NGR1) displays anti-inflammatory properties in numerou...
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Inhalation exposure to toxic heavy metals in nail salon technicians and health risk assessment using Monte Carlo simulation Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-26 Zohreh Mohebian, Fatemeh Paridokht, Sara Karimi Zeverdegani, Farzaneh Mohammadi
Nail salons offer a developing and diverse occupation for many women, especially the new generation. Due to the increasing apprehension surrounding heavy metals in dust caused by filing nails conta...
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Comparison of the effects of active and passive smoking of tobacco cigarettes, electronic nicotine delivery systems and tobacco heating products on the expression and secretion of oxidative stress and inflammatory response markers. A systematic review Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-23 Paulina Natalia Kopa-Stojak, Rafal Pawliczak
This work attempts to summarize current knowledge on the effects of active and passive smoking of cigarettes, electronic nicotine delivery systems and tobacco heating products on the expression and...
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Inhaled endotoxin induces a systemic neutrophil response without affecting cardiovascular measures in a randomized cross-over exposure study Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-18 Stephen A. Schworer, Alan L. Hinderliter, Melissa C. Caughey, Carole Robinette, Kelly D. Chason, Haolin Li, Haibo Zhou, Amika K. Sood, Allison J. Burbank, David B. Peden, Michelle L. Hernandez
The gram-negative bacterial cell wall component endotoxin (lipopolysaccharide, LPS) is a key component of particulate matter (PM). PM exposure is associated with cardiovascular morbidity and mortal...
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Health burden of sugarcane burning on agricultural workers and nearby communities Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-13 Arthur D. Stem, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard J. Johnson, Jared M. Brown
Sugarcane is the most widely cultivated crop in the world, with equatorial developing nations performing most of this agriculture. Burning sugarcane is a common practice to facilitate harvest, prod...
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Comparison of microparticle transport and deposition in nasal cavity of three different age groups Inhalation toxicology. (IF 2.0) Pub Date : 2024-02-11 John Valerian Corda, B. Satish Shenoy, Kamarul Arifin Ahmad, Leslie Lewis, Prakashini K, Anoop Rao, Mohammad Zuber
Objective: The nasal cavity effectively captures the particles present in inhaled air, thereby preventing harmful and toxic pollutants from reaching the lungs. This filtering ability of the nasal c...
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Lysosomal BK channels facilitate silica-induced inflammation in macrophages Inhalation toxicology. (IF 2.0) Pub Date : 2024-01-23 Rebekah L. Kendall, Andrij Holian
Lysosomal ion channels are proposed therapeutic targets for a number of diseases, including those driven by NLRP3 inflammasome-mediated inflammation. Here, the specific role of the lysosomal big co...
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Establishing short-term occupational exposure limits (STELs) for sensory irritants using predictive and in silico respiratory rate depression (RD50) models Inhalation toxicology. (IF 2.0) Pub Date : 2024-01-22 Anthony J. Russell, Melissa Vincent, Amanda N. Buerger, Scott Dotson, Jason Lotter, Andrew Maier
Sensory irritation is a health endpoint that serves as the critical effect basis for many occupational exposure limits (OELs). Schaper 1993 described a significant relationship with high correlatio...
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Long-term health complications of chemical weapon exposure: a study on Halabja chemical attack survivors (Iraqi Kurds) Inhalation toxicology. (IF 2.0) Pub Date : 2024-01-08 Belal A. Muhammad, Salih A. Hama, Karzan A.M Hawrami, Salar H. Karim, Gasha S. Ahmed, Hawbash M. Rahim
In 1988, the Iraqi government used a range of chemical weapons (CWs) against the Iraqi Kurds of Halabja. Here, we aim to investigate the long-term health consequences in exposed survivors as they a...
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Analysis of abnormal expression of signaling pathways in PQ-induced acute lung injury in SD rats based on RNA-seq technology Inhalation toxicology. (IF 2.0) Pub Date : 2024-01-04 Nan Li, Yue Huang, Yang Yi, Jin Qian, Qi Li, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Ji-Chao Peng, Li-Hua Li, Jin-Jian Yao, Xiao-Ran Liu
Background: Paraquat (PQ) plays an important role in agricultural production due to its highly effective herbicidal effect. However, it has led to multiple organ failure in those who have been pois...
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Impact of black soot emissions on public health in Niger Delta, Nigeria: understanding the severity of the problem Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-25 Osazuwa Clinton Ekhator, Fortune Chiemelie Orish, Ernest O. Nnadi, Daprim Samuel Ogaji, Success Isuman, Orish Ebere Orisakwe
Rivers State, Niger Delta, Nigeria often referred to as the ‘treasure bed of the nation’ is the seat of crude oil production activities with the accompanying environmental degradation. The severity...
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Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-13 Alexandra Noël, Ashlyn C. Harmon, Balamurugan Subramanian, Zakia Perveen, Ankit Aryal, Kelsey Legendre, Hasan Zaman, Daniel B. Paulsen, Kurt J. Varner, Tammy R. Dugas, Arthur L. Penn
Exposures to particulate matter (PM) from combustion sources can exacerbate preexisting asthma. However, the cellular and molecular mechanisms by which PM promotes the exacerbation of asthma remain...
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Airway contraction and cytokine release in isolated rat lungs induced by wear particles from the road and tire interface and road vehicle brakes Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-13 Ali Reza Nosratabadi, Mats Gustafsson, Karin Lovén, Stefan A. Ljunggren, Ulf Olofsson, Saeed Abbasi, Göran Blomqvist, Helen Karlsson, Anders G. Ljungman, Flemming R. Cassee, Miriam E. Gerlofs-Nijland, Anders Gudmundsson
The dominant road traffic particle sources are wear particles from the road and tire interface, and from vehicle brake pads. The aim of this work was to investigate the effect of road and brake wea...
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Vaping product exposure system (VaPES): a novel in vitro aerosol deposition system Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-13 Kevin D. Schichlein, Charlotte A. Love, Maxwell P. Conolly, John L. Kurz, Elise D. Hickman, Phillip W. Clapp, Ilona Jaspers
Due to recent increases in the use of vaping devices, there is a high demand for research addressing the respiratory health effects of vaping products. Given the constantly changing nature of the v...
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Toxic chemical exposures among civilians in armed conflicts: the need for research equity, justice, and accountability Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-07 Sammy Almashat, Melissa McDiarmid
Armed conflicts result in the release of toxic chemicals into the surrounding environment and civilians are commonly exposed to these toxicants.This paper reviews the evidence on civilian exposure ...
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Development of a non-target strategy for evaluation of potential biological effects of inhalable aerosols generated during purposeful room conditioning using an in vitro inhalation model Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-07 Detlef Ritter, Jan Knebel, Tanja Hansen, Anne Zifle, Anne Fuchs, Rolf Fautz, Katharina Schwarz
Objectives: An integrated in vitro inhalation approach was outlined to estimate potential adverse acute inhalation effects of aerosols from commercial nebulizer applications used for purposeful roo...
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Time to treat the climate and nature crisis as one indivisible global health emergency Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-07 Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E. Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
Published in Inhalation Toxicology: International Forum for Respiratory Research (Vol. 35, No. 11-12, 2023)
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Reconstruction of exposure to methylene diphenyl-4,4′-diisocyanate (MDI) aerosol using computational fluid dynamics, physiologically based toxicokinetics and statistical modeling Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-07 Sajjad Mozaffari, Majid Bayatian, Nan-Hung Hsieh, Monireh Khadem, Amir Abbasi Garmaroudi, Khosro Ashrafi, Seyed Jamaleddin Shahtaheri
This study employed computational fluid dynamics (CFD), physiologically based toxicokinetics (PBTK), and statistical modeling to reconstruct exposure to methylene diphenyl-4,4'-diisocyanate (MDI) a...
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Lung asbestos fiber burden analysis: effects of the counting rules for legal medicine evaluations Inhalation toxicology. (IF 2.0) Pub Date : 2023-12-07 Anna Benedetta Somigliana, Pietro Gino Barbieri, Alessandro Cavallo, Roberto Colombo, Dario Consonni, Dario Mirabelli
The work shows the effect of counting rules, such as analysis magnification and asbestos fiber dimension to be count (with length ≥5 µm or also asbestos fibers with length <5 µm) in the lung asbest...
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Real-time characterization of chemical threat agent aerosols for improvement of inhalation studies Inhalation toxicology. (IF 2.0) Pub Date : 2023-09-20 Mirjam de Bruin-Hoegée, Duurt P. W. Alkema, Ruud W. Busker, Marloes J.A Joosen, Arjan L. van Wuijckhuijse
Deliberate or accidental release of chemical treat agents in the aerosol form can cause an inhalation hazard. Since the relationship between aerosol properties and health hazards is poorly understo...
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Correction Inhalation toxicology. (IF 2.0) Pub Date : 2023-08-21
Published in Inhalation Toxicology: International Forum for Respiratory Research (Vol. 35, No. 9-10, 2023)
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Natural mineral fibers: conducting inhalation toxicology studies – part A: Libby Amphibole aerosol generation and characterization method development Inhalation toxicology. (IF 2.0) Pub Date : 2023-06-20 Anbo Wang, Amit Gupta, Michael D. Grimm, David T. Pressburger, Barney R. Sparrow, Jamie S. Richey, John R. Shaw, Karen E. Elsass, Georgia K. Roberts, Pei-Li Yao, Matthew D. Stout, Benjamin J. Ellis, Robyn L. Ray
Abstract Background Asbestos has been classified as a human carcinogen, and exposure may increase the risk of diseases associated with impaired respiratory function. As the range of health effects and airborne concentrations that result in health effects across asbestos-related natural mineral fiber types are not fully understood, the National Institute of Environmental Health Sciences has established
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Natural mineral fibers: conducting inhalation toxicology studies—part B: development of a nose-only exposure system for repeat-exposure in vivo study of Libby amphibole aerosol Inhalation toxicology. (IF 2.0) Pub Date : 2023-06-20 Anbo Wang, Amit Gupta, Michael D. Grimm, David T. Pressburger, Barney R. Sparrow, Jamie S. Richey, John R. Shaw, Karen E. Elsass, Georgia K. Roberts, Pei-Li Yao, Matthew D. Stout, Benjamin J. Ellis, Robyn L. Ray
Abstract Background Exposure to asbestos is associated with malignant and nonmalignant respiratory disease. To strengthen the scientific basis for risk assessment on fibers, the National Institute of Environmental Health Sciences (NIEHS) has initiated a series of studies to address fundamental questions on the toxicology of naturally occurring asbestos and related mineral fibers after inhalation exposure
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Biological effects of inhaled crude oil vapor. III. Pulmonary inflammation, cytotoxicity, and gene expression profile Inhalation toxicology. (IF 2.0) Pub Date : 2023-06-18 Tina M. Sager, Pius Joseph, Christina M. Umbright, Ann F. Hubbs, Mark Barger, Michael L. Kashon, Jeffrey S. Fedan, Jenny R. Roberts
Workers may be exposed to vapors emitted from crude oil in upstream operations in the oil and gas industry. Although the toxicity of crude oil constituents has been studied, there are very few in v...
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Perturbations in indices of oxidative stress, oxidative DNA damage and lung function in chronic exposure to wood dust in Southern Nigeria Inhalation toxicology. (IF 2.0) Pub Date : 2023-06-16 Augusta Chinyere Nsonwu-Anyanwu, Raymond Ekong Eworo, Unyime Aniekpon Fabian, Uduak Luke, Caroline Chinenyenwa Thomas, Olivia Kamsi Muoka, Unwanaabasi Okon Ufot, Chinyere Adanna Opara Usoro
Oxidative stress (OS) and oxidative DNA damage accruing from chronic exposure to wood dust have been implicated in the development of chronic lung conditions among woodworkers. Indices of OS, infla...
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Toxicological and epidemiological approaches to carcinogenic potency modeling for mixed mineral fiber exposure: the case of fibrous balangeroite and chrysotile Inhalation toxicology. (IF 2.0) Pub Date : 2023-05-23 Andrey A. Korchevskiy, Ann G. Wylie
Abstract Context Excess mesothelioma risk was observed among chrysotile miners and millers in Balangero, Italy. The mineral balangeroite has been identified in an asbestiform habit from the Balangero chrysotile mine (Italy). Previous studies did not contain a detailed description of the fiber dimensions, thus limiting possible approaches to estimating their carcinogenic potential. Objectives To reconstruct
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Characterization of aerosols from hemp-derived pre-roll joints Inhalation toxicology. (IF 2.0) Pub Date : 2023-05-09 Hammad Irshad, Justyna Kulpa, Philip J. Kuehl, Tim Lefever, Jacob D. McDonald
Abstract Objective Availability and consumer use of hemp products is rapidly increasing, but little work has been done to assess aerosol emissions of hemp pre-rolls. The objective of this research was to characterize the aerosol of pre-rolled joints from hemp material enriched for production of cannabigerol (CBG) that were smoked on a test system mimicking human use patterns. Materials and methods
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Impact of waterpipe and tobacco cigarette smoking on global DNA methylation and nuclear proteins genes transcription in spermatozoa: a comparative investigation Inhalation toxicology. (IF 2.0) Pub Date : 2023-05-05 Mohammed M. Laqqan, Said S. Al-Ghora, Maged M. Yassin
Abstract Background Waterpipe smoking is harmful and dangerous, and it is a growing threat to public health. Objectives This study was performed to evaluate the influence of waterpipe smoking on global DNA methylation, DNA fragmentation, and protamine deficiency in spermatozoa compared to cigarette heavy smokers and nonsmokers, and to determine whether the transcription levels of spermatozoa nuclear
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The effects of inhaled pollutants on reproduction in marginalized communities: a contemporary review Inhalation toxicology. (IF 2.0) Pub Date : 2023-04-19 Ramsés Santacruz-Márquez, Alison M. Neff, Vasiliki E. Mourikes, Endia J. Fletcher, Jodi A. Flaws
Important differences in health that are closely linked with social disadvantage exist within and between countries. According to the World Health Organization, life expectancy and good health cont...
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Persistent changes in expression of genes involved in inflammation and fibrosis in the lungs of rats exposed to airborne lunar dust Inhalation toxicology. (IF 2.0) Pub Date : 2023-03-26 Ye Zhang, Michael Story, Samrawit Yeshitla, Xiaoyu Wang, Robert R. Scully, Corey Theriot, Honglu Wu, Valerie E. Ryder, Chiu-wing Lam
Abstract NASA is currently planning return missions to the Moon for further exploration and research. The Moon is covered by a layer of potentially reactive fine dust, which could pose a toxicological risk of exposure to explorers. To assess this risk, we exposed rats to lunar dust (LD) that was collected during the Apollo14 mission. Rats were exposed to respirable sizes of LD at concentrations of
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Correction Inhalation toxicology. (IF 2.0) Pub Date : 2023-03-19
Published in Inhalation Toxicology: International Forum for Respiratory Research (Vol. 35, No. 3-4, 2023)
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Altered long non-coding RNAs expression in normal and diseased primary human airway epithelial cells exposed to diesel exhaust particles Inhalation toxicology. (IF 2.0) Pub Date : 2023-03-06 C. M. Sabbir Ahmed, Alexa Canchola, Biplab Paul, Md Rubaiat Nurul Alam, Ying-Hsuan Lin
Abstract Background Exposure to diesel exhaust particles (DEP) has been linked to a variety of adverse health effects, including increased morbidity and mortality from cardiovascular diseases, chronic obstructive pulmonary disease (COPD), metabolic syndrome, and lung cancer. The epigenetic changes caused by air pollution have been associated with increased health risks. However, the exact molecular
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Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: a perspective Inhalation toxicology. (IF 2.0) Pub Date : 2023-02-07 Urmila P. Kodavanti, Thomas W. Jackson, Andres R. Henriquez, Samantha J. Snow, Devin I. Alewel, Daniel L. Costa
Abstract Air pollutants are being increasingly linked to extrapulmonary multi-organ effects. Specifically, recent studies associate air pollutants with brain disorders including psychiatric conditions, neuroinflammation and chronic diseases. Current evidence of the linkages between neuropsychiatric conditions and chronic peripheral immune and metabolic diseases provides insights on the potential role
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Contributions of particulate and gas phases of simulated burn pit smoke exposures to impairment of respiratory function Inhalation toxicology. (IF 2.0) Pub Date : 2023-01-24 Samuel A. Vance, Yong Ho Kim, Ingrid J. George, Janice A. Dye, Wanda C. Williams, Mette J. Schladweiler, M. Ian Gilmour, Ilona Jaspers, Stephen H. Gavett
Abstract Objective Inhalation of smoke from the burning of waste materials on military bases is associated with increased incidences of cardiopulmonary diseases. This study examined the respiratory and inflammatory effects of acute inhalation exposures in mice to smoke generated by military burn pit-related materials including plywood (PW), cardboard (CB), mixed plastics (PL), and a mixture of these
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Predicting the in vitro dissolution rate constant of mineral wool fibers from fiber composition Inhalation toxicology. (IF 2.0) Pub Date : 2023-01-17 Russell M. Potter, John W. Hoffman, John G. Hadley
Abstract Objective We developed predictive formulae for the in vitro dissolution rate constant kdis of acid-soluble synthetic vitreous fibers (SVF), paralleling our earlier work with glass wools, which are typically more soluble at neutral pH. Developing simple models for predicting the kdis of a fiber can allow prediction of in vivo behavior, aid fiber developers, and potentially reduce in vivo testing
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Toxicological evaluation of polycrystalline wools in human lung cells Inhalation toxicology. (IF 2.0) Pub Date : 2023-01-17 Aureliano Ciervo, Cinzia Lucia Ursini, Anna Maria Fresegna, Raffaele Maiello, Antonella Campopiano, Sergio Iavicoli, Delia Cavallo
Abstract Aim: Polycrystalline wools (PCW) are included with Refractory ceramic fibers (RCF) in the alumino-silicates family of High Temperature Insulation Wools (HTIW). IARC includes PCW in the ceramic fibers group and considers them as possible human carcinogens (GROUP 2B). Since PCW toxicity is not yet clear, our aim was to evaluate their toxic and inflammatory effects and to compare them with the
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Analysis and forecasting of air quality index based on satellite data Inhalation toxicology. (IF 2.0) Pub Date : 2023-01-05 Tinku Singh, Nikhil Sharma, Satakshi, Manish Kumar
Abstract Objective The air quality index (AQI) forecasts are one of the most important aspects of improving urban public health and enabling society to remain sustainable despite the effects of air pollution. Pollution control organizations deploy ground stations to collect information about air pollutants. Establishing a ground station all-around is not feasible due to the cost involved. As an alternative
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Does long-term exposure to air pollution suppress parasympathetic reactivation after incremental exercise among healthy males and females? Inhalation toxicology. (IF 2.0) Pub Date : 2022-11-23 Sara Pouriamehr, Valiollah Dabidi Roshan, Farimah Shirani
Abstract Purpose As consequences of industrial processes, air pollution has led to increased cardiovascular diseases resulting in mortality. However, there are few pieces of evidence expressing physical fitness and gender impacts in such environments. Regarding long-term exposure to air pollution, this study aimed to determine the effect of physical fitness on post-exercise cardiac parasympathetic
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A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness Inhalation toxicology. (IF 2.0) Pub Date : 2022-11-17 Angela Cruz-Hernandez, Andrew Roney, Dinesh G. Goswami, Neera Tewari-Singh, Jared M. Brown
Abstract Over 40% of veterans from the Persian Gulf War (GW) (1990–1991) suffer from Gulf War Illness (GWI). Thirty years since the GW, the exposure and mechanism contributing to GWI remain unclear. One possible exposure that has been attributed to GWI are chemical warfare agents (CWAs). While there are treatments for isolated symptoms of GWI, the number of respiratory and cognitive/neurological issues