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Mechanism study of YangJing ZhongYu decoction on regulating mitochondrial dynamics of ovarian granular cells and improving diminished ovarian reserve J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-17 Ping Li, Jilin Kuang
Diminished ovarian reserve (DOR) encompasses both reproductive and endocrine disorders, resulting in a decline in female fertility. This paper explored the mechanism of Yangjing Zhongyu Decoction (YJZYD) regulating mitochondrial dynamics of ovarian granulosa cells (GCs) to improve DOR. DOR patients were treated with YJZYD, with ovarian volume (OV), antral follicle count (AFC), and endometrial thickness
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The synergistic mechanisms of propofol with cisplatin or doxorubicin in human ovarian cancer cells J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-14 Sung-How Sue, Wei-Cheng Tseng, Zih-Syuan Wu, Shih-Ming Huang, Jia-Lin Chen, Zhi-Fu Wu, Hou-Chuan Lai
Most ovarian cancer cases are diagnosed at an advanced stage, leading to poor outcomes and a relatively low 5-year survival rate. While tumor resection in the early stages can be highly effective, recurrence following primary treatment remains a significant cause of mortality. Propofol is a commonly used intravenous anesthetic agent in cancer resection surgery. Previous research has shown that propofol
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The discriminatory capability of anthropometric measures in predicting reproductive outcomes in Chinese women with PCOS J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-13 Qing Xia, Qi Wu, Jiaxing Feng, Hui He, Wangyu Cai, Jian Li, Jing Cong, Hongli Ma, Liyan Jia, Liangzhen Xie, Xiaoke Wu
Obesity is a common feature in women with polycystic ovary syndrome (PCOS) and potentially significantly influences reproductive function. However, opinions are divided as to which factor is a more appropriate obesity predictor of reproductive outcomes. The aim of this study was to investigate the discriminatory capability of anthropometric measures in predicting reproductive outcomes in Chinese women
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Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian aging J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-13 Xuehan Zhao, Feiyan Zhao, Long Yan, Jiaqi Wu, Ying Fang, Cong Wang, Zhimin Xin, Xiaokui Yang
In-depth understanding of dynamic expression profiles of human granulosa cells (GCs) during follicular development will contribute to the diagnostic and targeted interventions for female infertility. However, genome-scale analysis of long non-coding ribonucleic acid (lncRNA) in GCs across diverse developmental stages is challenging. Meanwhile, further research is needed to determine how aberrant lncRNA
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Bone marrow mesenchymal stem cells expressing Neat-1, Hotair-1, miR-21, miR-644, and miR-144 subsided cyclophosphamide-induced ovarian insufficiency by remodeling the IGF-1–kisspeptin system, ovarian apoptosis, and angiogenesis J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-12 Amany I. Ahmed, Mohamed F. Dowidar, Asmaa F. Negm, Hussein Abdellatif, Asma Alanazi, Mohammed Alassiri, Walaa Samy, Dina Mohamed Mekawy, Eman M. A. Abdelghany, Nesma I. El-Naseery, Mohamed A. Ibrahem, Emad Ali Albadawi, Wed Salah, Mamdouh Eldesoqui, Emil Tîrziu, Iulia Maria Bucur, Ahmed Hamed Arisha, Tarek Khamis
Ovarian insufficiency is one of the common reproductive disorders affecting women with limited therapeutic aids. Mesenchymal stem cells have been investigated in such disorders before yet, the exact mechanism of MSCs in ovarian regeneration regarding their epigenetic regulation remains elusive. The current study is to investigate the role of the bone marrow-derived mesenchymal stem cells (BM-MSCs)
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Research progress of ferroptosis in female infertility J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-12 Fan peiyin, Wang yuxian, Zhang jiali, Xu jian
Ferroptosis is a novel type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides in cells and is closely related to various diseases. Female infertility is a global health concern, which is associated with a variety of factors. The etiology remains unknown in many women with infertility. With further investigation into the pathogenesis of infertility,
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Stem cell-derived extracellular vesicles in premature ovarian failure: an up-to-date meta-analysis of animal studies J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-09 Yan Luo, Jingjing Chen, Jinyao Ning, Yuanyuan Sun, Yitong Chai, Fen Xiao, Bixia Huang, Ge Li, Fen Tian, Jie Hao, Qiong Zhang, Jing Zhao, Yanping Li, Hui Li
There has been a significant surge in animal studies of stem cell-derived extracellular vesicles (EVs) therapy for the treatment of premature ovarian failure (POF) but its efficacy remains unknown and a comprehensive and up-to-date meta-analysis is lacking. Before clinical translation, it is crucial to thoroughly understand the overall impact of stem cell-derived EVs on POF. PubMed, EMBASE, Cochrane
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Evaluation of the cytotoxic activity of chemically characterized propolis originating from different geographic regions and vitamin D co-supplementation against human ovarian cancer cells J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-07 Eman Ali, Maged W. Helmy, Eman H. Radwan, Karoline K. Abdul Aziz, Aida A. Abd El-Wahed, Lamia M. El-Samad, Abeer El Wakil
Ovarian cancer is the second most common and lethal gynecologic malignancy. Among natural product-based therapy, the honeybee products, particularly propolis, serve a valuable source contributing directly to human nutrition and health. In the present study, we determined the chemical composition of different types of propolis originating from Egypt, Germany and France using liquid chromatography-tandem
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A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility J. Ovarian Res. (IF 3.8) Pub Date : 2024-09-04 Juepu Zhou, Ruolin Mao, Meng Wang, Rui Long, Limin Gao, Xiangfei Wang, Lei Jin, Lixia Zhu
Pannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions. Variants in the PANX1 gene have been reported to be associated with oocyte death and recurrent in vitro fertilization failure. In this study, we identified a novel heterozygous PANX1 variant (NM_015368.4 c.410 C > T (p.Ser137Leu))
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Increasing dominant follicular proportion was associated with adverse IVF/ICSI outcomes in low-prognosis women undergoing GnRH antagonist protocol: a retrospective cohort study J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-31 Qijun Xie, Wei Jiang, Yi Wei, Danyu Ni, Nan Yan, Ye Yang, Chun Zhao, Rong Shen, Xiufeng Ling
This study aimed to examine the correlation between different dominant follicle proportions (DFPs) and outcomes of in-vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) among patients classified under POSEIDON Groups 3 and 4, who underwent gonadotropin-releasing hormone antagonist (GnRH-ant) protocols. Additionally, it sought to determine the optimal DFP threshold for trigger timing
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SCM-198 ameliorates the quality of postovulatory and maternally aged oocytes by reducing oxidative stress J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-31 Wei Ma, Xi Zhao, Qingxin Wang, Xue Wu, Tingting Yang, Yuqi Chen, Yizhun Zhu, Xia Wang
Oocyte aging is a key constraint on oocyte quality, leading to fertilization failure and abnormal embryonic development. In addition, it is likely to generate unfavorable assisted reproductive technology (ART) outcomes. SCM-198, a synthetic form of leonurine, was found to rescue the rate of oocyte fragmentation caused by postovulatory aging. Therefore, the aim of this study was to conduct a more in-depth
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Efficacy and safety of Shen Que (RN8) moxibustion on reproductive outcomes in unexpected poor ovarian responders: a randomized controlled trial J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-29 Jing-Yan Song, Zhen-Gao Sun, Yu-Xia Ma
Managing infertility patients with poor ovarian response (POR) to ovarian stimulation remains unmet clinically. Besides economic burdens, patients with POR have a poor prognosis during in vitro fertilization and embryo transfer (IVF-ET). In this study, we assessed the efficacy and safety of Shen Que (RN8) moxibustion on reproductive outcomes in POSEIDON patients (Group 2a). Women eligible for IVF were
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B4GALT5 a sialylation-related genes associated with patient prognosis and immune microenvironment in ovarian cancer and pan-cancer J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-29 Di Wu, Li-yuan Sun, Xin-yu Chang, Guang-mei Zhang
Ovarian cancer (OC) is the predominant primary tumor in the human reproductive system. Abnormal sialylation has a significant impact on tumor development, metastasis, immune evasion, angiogenesis, and treatment resistance. B4GALT5, a gene associated with sialylation, plays a crucial role in ovarian cancer, and may potentially affect clinicopathological characteristics and prognosis. We conducted a
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Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-28 Shiwei Wang, Xuan Wu, Juan Yang, Yuwan Peng, Fulu Miao, Min Li, Juan Zeng
Sterigmatocystin (STE) is a mycotoxin widely found in contaminated food and foodstuffs, and excessive long-term exposure to STE is associated with several health issues, including infertility. However, there is little information available regarding the effects of STE toxin on the female reproductive system, particularly concerning oocyte maturation. In the present study, we investigated the toxic
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Association of HOMA-IR with unexpected poor ovarian response in non-obese women in poseidon 1: a retrospective cohort study J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-28 Yan Li, Shaodi Zhang, Cuilian Zhang
Insulin resistance (IR) is related with adverse outcomes of in vitro fertilization (IVF) in women with obesity, but little is known about the relationship between IR and unexpected poor ovarian response (uPOR) in non-obese subjects with sufficient ovarian parameters (classified as POSEIDON group 1). This research aims to explore the association between the homeostasis model assessment of insulin resistance
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The diagnostic performance of CA-125 for the detection of ovarian cancer in women from different ethnic groups: a cohort study of English primary care data J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-26 Melissa Barlow, Liz Down, Luke T. A. Mounce, Garth Funston, Samuel W. D. Merriel, Jessica Watson, Gary Abel, Lucy Kirkland, Tanimola Martins, Sarah E. R. Bailey
CA-125 testing is a recommended first line investigation for women presenting with possible symptoms of ovarian cancer in English primary care, to help determine whether further investigation for ovarian cancer is needed. It is currently not known how well the CA-125 test performs in ovarian cancer detection for patients from different ethnic groups. A retrospective cohort study utilising English primary
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Ovarian cancer derived extracellular vesicles promote the cancer progression and angiogenesis by mediating M2 macrophages polarization J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-24 Xue Tang, Chengbin Ma, Qiongwei Wu, Meng Yu
Extracellular vesicles (EVs) are mediators between cancer cells and other types of cells, such as tumor-associated macrophages (TAMs), in the tumor microenvironment. EVs can remodel the tumor microenvironment and regulate tumor progression. However, the underlying molecular mechanism of these interactions remains unclear. First, we explored the effect of TAMs on the survival prognosis of patients with
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Stem cell-based therapeutic potential in female ovarian aging and infertility J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-24 Xiangrong Cui, Xuan Jing
Premature ovarian insufficiency (POI) is defined as onset of menopause characterized by amenorrhea, hypergonadotropism, and hypoestrogenism, before the age of 40 years. The POI is increasing, which seriously affects the quality of patients’ life. Due to its diversity of pathogenic factors, complex pathogenesis and limited treatment methods, the search for finding effective treatment of POI has become
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Prognostic analysis of peritoneal washing cytology during interval debulking surgery in advanced ovarian cancer J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-24 Kazuki Takasaki, Takayuki Ichinose, Haruka Nishida, Yuko Miyagawa, Kei Hashimoto, Saya Watanabe, Yuko Takahashi, Mana Hirano, Haruko Hiraike, Yuko Sasajima, Kazunori Nagasaka
Interval debulking surgery (IDS) following neoadjuvant chemotherapy is a treatment option for advanced ovarian cancer. Optimal surgery is required for better survival; however, while peritoneal washing cytology (PWC) has been identified as a prognostic factor, its comprehensive assessment during IDS remains unexplored. Therefore, we aimed to evaluate PWC efficacy during IDS, alongside other factors
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Preovulatory progesterone levels are the top indicator for ovulation prediction based on machine learning model evaluation: a retrospective study J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-21 Yumei Li, Hong Zeng, Jing Fu
Accurately predicting ovulation timing is critical for women undergoing natural cycle-frozen embryo transfer. However, the precise predicting of the ovulation timing remains challenging due to the lack of consensus among different clinics regarding the definition of this significant event. To compare the effectiveness of preovulatory serum progesterone levels (P4) versus luteinizing hormone levels
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Correction: Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-19 Nahideh Nazdikbin Yamchi, Shahin Ahmadian, Halimeh Mobarak, Farhad Amjadi, Rahim Beheshti, Amin Tamadon, Reza Rahbarghazi, Mahdi Mahdipour
Correction: J Ovarian Res 16, 118 (2023) https://doi.org/10.1186/s13048-023-01214-1 Following publication of the original article [1], the authors reported that Figs. 3 and 4 have been updated due to unintentional errors when compiling the data. The correct figures were included in this correction. Corrected figure 3: Corrected figure 4: The original article [1] has been corrected. Nazdikbin Yamchi
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Granulosa cell insight: unraveling the potential of menstrual blood-derived stem cells and their exosomes on mitochondrial mechanisms in polycystic ovary syndrome (PCOS) J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-17 Mahna Mansoori, Somayeh Solhjoo, Maria Grazia Palmerini, Seyed Noureddin Nematollahi-Mahani, Massood Ezzatabadipour
Polycystic ovary syndrome (PCOS) presents a significant challenge in women’s reproductive health, characterized by disrupted folliculogenesis and ovulatory dysfunction. Central to PCOS pathogenesis are granulosa cells, whose dysfunction contributes to aberrant steroid hormone production and oxidative stress. Mitochondrial dysfunction emerges as a key player, influencing cellular energetics, oxidative
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A metabolome-wide Mendelian randomization study prioritizes causal circulating metabolites for reproductive disorders including primary ovarian insufficiency, polycystic ovary syndrome, and abnormal spermatozoa J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-14 Shuang Chen, Shihao Sun, Mingshu Cai, Zhaokai Zhou, Yuan Ma, Zihan Zhou, Fang Wang, Jinhao Liu, Wenyan Song, Yu Liu, Kai Huang, Qingling Yang, Yihong Guo
Accumulating studies have highlighted the significant role of circulating metabolomics in the etiology of reproductive system disorders. However, the causal effects between genetically determined metabolites (GDMs) and reproductive diseases, including primary ovarian insufficiency (POI), polycystic ovary syndrome (PCOS), and abnormal spermatozoa (AS), still await thorough clarification. With the currently
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Evaluation of ovarian reserve and the assisted reproductive technology (ART) cycles’ outcome as well as the relapse rate within one year after ART in women with multiple sclerosis: a case-control study J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-13 Arezoo Arabipoor, Ashraf Moini, Seyed Massood Nabavi, Shima Mohiti, Mehri Mashayekhi, Zahra Zolfaghari
To compare the ovarian reserve and the results of infertility treatment, as well as to investigate the relapse rate in the first year after the assisted reproductive technology (ART) cycle in patients with multiple sclerosis (MS) referred to Royan Institute. This retrospective study was carried out to evaluate all women diagnosed with MS and referred to Royan Institute for assessment and treatment
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CA-125:CA72-4 ratio − towards a promising cost-effective tool in ovarian cancer diagnosis and monitoring of post-menopausal women under hormone treatment J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-10 Angeliki Margoni, Antonios N. Gargalionis, Athanasios G. Papavassiliou
Ovarian cancer (OC) is the most lethal gynecological cancer in the developed world. Most cases are diagnosed at late stage III-IV with a very low 5-year overall survival rate. Several studies revealed an elevated risk of OC in users of hormone treatment (HT) compared with non-users. The extended duration of HT is a statistically significant risk factor. Carbohydrate antigen or cancer antigen 125 (CA-125)
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Effect of astaxanthin supplementation on female fertility and reproductive outcomes: a systematic review and meta-analysis of clinical and animal studies J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-10 Arezoo Maleki-Hajiagha, Anahid Shafie, Khadije Maajani, Fardin Amidi
Oxidative stress (OS) plays a harmful role in female reproduction and fertility. Several studies explored various dietary interventions and antioxidant supplements, such as astaxanthin (AST), to mitigate the adverse effects of OS on female fertility. Ameliorative effects of AST on female fertility and the redox status of reproductive organs have been shown in several animal and clinical studies. The
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Dachsous cadherin related 1 (DCHS1) is a novel biomarker for immune infiltration and epithelial-mesenchymal transition in endometrial cancer via pan-cancer analysis J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-09 Cai Meijuan, Min Fang, Wang qian
Dachsous cadherin related 1 (DCHS1) is one of calcium-dependent adhesion membrane proteins and is mainly involved in the development of mammalian tissues. There is a lack of more detailed research on the biological function of DCHS1 in pan-cancer. We evaluated the expression, the prognostic value, the diagnostic value and genomic alterations of DCHS1 by using the databases, including TCGA, UALCAN,
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Emerging role of mucins in antibody drug conjugates for ovarian cancer therapy J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-08 Shabnam Malik, Mohammed Sikander, Natasha Bell, Daniel Zubieta, Maria C. Bell, Murali M. Yallapu, Subhash C. Chauhan
Ovarian cancer stands as the deadliest gynecologic malignancy, responsible for nearly 65% of all gynecologic cancer-related deaths. The challenges in early detection and diagnosis, coupled with the widespread intraperitoneal spread of cancer cells and resistance to chemotherapy, contribute significantly to the high mortality rate of this disease. Due to the absence of specific symptoms and the lack
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Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-05 Cyntia Duval, Brandon A. Wyse, Benjamin K. Tsang, Clifford L. Librach
Extracellular vesicles (EVs), particles enriched in bioactive molecules like proteins, nucleic acids, and lipids, are crucial mediators of intercellular communication and play key roles in various physiological and pathological processes. EVs have been shown to be involved in ovarian follicular function and to be altered in two prevalent gynecological disorders; polycystic ovarian syndrome (PCOS) and
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The molecular prognostic score, a classifier for risk stratification of high-grade serous ovarian cancer J. Ovarian Res. (IF 3.8) Pub Date : 2024-08-02 Siddik Sarkar, Sarbar Ali Saha, Abhishek Swarnakar, Arnab Chakrabarty, Avipsa Dey, Poulomi Sarkar, Sarthak Banerjee, Pralay Mitra
The clinicopathological parameters such as residual tumor, grade, the International Federation of Gynecology and Obstetrics (FIGO) score are often used to predict the survival of ovarian cancer patients, but the 5-year survival of high grade serous ovarian cancer (HGSOC) still remains around 30%. Hence, the relentless pursuit of enhanced prognostic tools for HGSOC, this study introduces an unprecedented
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Drug-free in vitro activation combined with ADSCs-derived exosomes restores ovarian function of rats with premature ovarian insufficiency J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-31 Qian Li, Zhiqiang Zhang, Wenxin Shi, Zhongkang Li, Yanlai Xiao, Jingkun Zhang, Xianghua Huang
Drug-free in vitro activation (IVA) is a new protocol to activate residual dormant follicles for fertility restoration in patients with premature ovarian insufficiency (POI). However, several deficiencies have reduced its clinical efficacy rate. Our previous studies have confirmed that the combination of adipose-derived stem cells (ADSCs) and drug-free IVA can improve the effectiveness of drug-free
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Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-30 Hadis Hooshmandi, Akram Ghadiri-Anari, Ali Mohammad Ranjbar, Hossein Fallahzadeh, Mahdieh Hosseinzadeh, Azadeh Nadjarzadeh
Polycystic ovary syndrome (PCOS) is the most common ovarian dysfunction. Recent studies showed the effectiveness of licorice on metabolic profiles with inconsistent findings. So, we investigated the effect of licorice on obesity indices, glycemic indices, and lipid profiles in women with PCOS. This randomized, double-blind, placebo-controlled trial was performed on 66 overweight/obese women with PCOS
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Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-27 Riya Khetan, Preethi Eldi, Noor A. Lokman, Carmela Ricciardelli, Martin K. Oehler, Anton Blencowe, Sanjay Garg, Katherine Pillman, Hugo Albrecht
Genetic heterogeneity in ovarian cancer indicates the need for personalised treatment approaches. Currently, very few G-protein coupled receptors (GPCRs) have been investigated for active targeting with nanomedicines such as antibody-conjugated drugs and drug-loaded nanoparticles, highlighting a neglected potential to develop personalised treatment. To address the genetic heterogeneity of ovarian cancer
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Correction: Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-27 Liping Hu, Guolin Hong, Jingzhi Li, Mengkun Chen, Chih-Jung Chang, Po-Jen Cheng, Zhimei Zhang, Xinli Zhang, Huiping Chen, Yingting Zhuang, Yuqin Li
Correction: J Ovarian Res 17, 136 (2024) https://doi.org/10.1186/s13048-024-01444-x Following publication of the original article [1], the authors reported that affiliations of author ‘Guolin Hong’ and affiliation 3 were incorrectly presented. The author group is presented correctly in this correction article. The original article [1] has been corrected. Hu L, Hong G, Li J, et al. Metformin modifies
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Effects of mind-body interventions on polycystic ovary syndrome: a comprehensive meta-analysis J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-25 Kun Zhao, Liuyan Nie, Xiangming Ye, Xiaoyan Hu
Mind-body interventions (MBI) have emerged as a potential therapeutic approach, but their effectiveness in the treatment of Polycystic Ovary Syndrome (PCOS) remains inconclusive. This study systematically evaluates the effectiveness of MBI on quality of life, anthropometry, androgen secretion, glucose, and lipid metabolism in PCOS. A computer search was conducted across three databases: PubMed, the
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The natural menstrual cycle revisited – can natural cycle be trusted J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-22 B Alsbjerg, US Kesmodel, P Humaidan, L Bungum
The serum progesterone (P4) level during the luteal phase (LP) plays a crucial role in the initiation and maintenance of pregnancy. However, it is unclear whether the natural cycle consistently provides the best endocrine profile and whether mid-luteal serum P4 levels are always sufficient to support implantation and early pregnancy. The question has become more relevant in relation to fertility treatment
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External validation of Standardized KELIM and platinum-resistant recurrence scores in patients with advanced epithelial ovarian cancer J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-22 Nina Oufkir, Roman Rouzier, Xavier Paoletti, Claire Bonneau
Neoadjuvant chemotherapy followed by interval debulking surgery is currently a common treatment option for advanced epithelial ovarian cancer (EOC). The Standardized CA-125 ELIMination rate constant K (Std KELIM) and the Platinum Resistant Recurrence (PtRR) Score have been proposed as markers of tumor chemosensitivity. The aim of our study was to validate these tools for predicting platinum sensitivity
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Hsa_circ_0043532 contributes to PCOS through upregulation of CYP19A1 by acting as a ceRNA for hsa-miR-1270 J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-22 Huimin Zhang, Jianye Fang, Yingxue Liu, Wenqian Zhu, Yangying Xu, Yu Zhang, Wei Shen, Duan Li, Cuifang Hao
Polycystic ovarian syndrome (PCOS) accounts for about 75% of anovulatory infertility. The cause of PCOS is not clear. CircRNAs acting as miRNA sponges mediate the post-transcriptional regulation of multiple genes. CYP19A1 is a limiting enzyme in the ovarian steroidogenesis pathway. However, the mechanism of circRNAs regulating granulosa cell (GC) estradiol secretion in PCOS remains to be elucidated
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Acetylation model predicts prognosis of patients and affects immune microenvironment infiltration in epithelial ovarian carcinoma J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-19 Xuan Wang, Xiaoning Li, Li Wei, Yankun Yu, Yeernaer Hazaisihan, Lin Tao, Wei Jia
Epithelial ovarian carcinoma (EOC) is a prevalent gynaecological malignancy. The prognosis of patients with EOC is related to acetylation modifications and immune responses in the tumour microenvironment (TME). However, the relationships between acetylation-related genes, patient prognosis, and the tumour immune microenvironment (TIME) are not yet understood. Our research aims to investigate the link
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Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-17 Tyler T. Cooper, Dylan Z. Dieters-Castator, Jiahui Liu, Gabrielle M. Siegers, Desmond Pink, Lorena Veliz, John D. Lewis, François Lagugné-Labarthet, Yangxin Fu, Helen Steed, Gilles A. Lajoie, Lynne-Marie Postovit
The five-year prognosis for patients with late-stage high-grade serous carcinoma (HGSC) remains dismal, underscoring the critical need for identifying early-stage biomarkers. This study explores the potential of extracellular vesicles (EVs) circulating in blood, which are believed to harbor proteomic cargo reflective of the HGSC microenvironment, as a source for biomarker discovery. We conducted a
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The role of vitamin D3 in follicle development J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-17 Mingxia Li, Shuhui Hu, Jiaxiang Sun, Ying Zhang
Vitamin D3 plays a crucial role in female reproduction. As research progresses, the mechanisms of action of vitamin D3 on follicular development have been widely discussed. Firstly, key enzymes involved in the synthesis and metabolism of vitamin D3 have been discovered in the ovary, suggesting that vitamin D3 can be synthesized and metabolized locally within the ovary. Additionally, the detection of
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Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-16 Xinling Wen, Li Wang, Fen Li, Xuewen Yu
The aim of this study was to explore the effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome (PCOS). A total of 60 PCOS women with vitamin D deficiency or insufficiency were enrolled in this randomized controlled trial. Participants were randomized to vitamin D group (2000 IU/day) or control group. The observational parameters were measured at baseline
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Causal association between telomere length and female reproductive endocrine diseases: a univariable and multivariable Mendelian randomization analysis J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-15 QiaoRui Yang, JinFu Zhang, ZhenLiang Fan
The relationship between leukocyte telomere length (LTL) and female reproductive endocrine diseases has gained significant attention and research interest in recent years. However, there is still limited understanding of the exact impacts of LTL on these diseases. Therefore, the primary objective of this study was to investigate the genetic causal association between LTL and female reproductive endocrine
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The impact of Paclitaxel-based hyperthermic intraperitoneal chemotherapy in advanced high-grade serous ovarian cancer patients - interim analysis of safety and immediate efficacy of a randomized control trial (C-HOC trial) J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-12 Qun Wang, Hua Liu, Yuhong Shen, Lifei Shen, Jian Li, Weiwei Feng
This study evaluates the potential superiority of combining paclitaxel-based hyperthermic intraperitoneal chemotherapy (HIPEC) with sequential intravenous neoadjuvant chemotherapy over intravenous neoadjuvant chemotherapy alone in Chinese patients with Federation of Gynecology and Obstetrics (FIGO) stage IIIC, IVA and IVB high-grade serous ovarian/fallopian tube carcinoma (HGSOC). This interim analysis
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The possible short-term of Nigella sativa – L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-12 Azamsadat Mahmoudian, Akram Ashouri, Roghaieh Rahmani Bilandi, Fatemeh Mohammadzadeh, Sareh Dashti, Narjes Bahri
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age and the most common cause of infertility due to anovulation. PCOS in adolescents is concerning. Nigella sativa is effective in improving gonadotropins and sex hormones. The current study was designed to investigate the effect of Nigella sativa supplementation on PCOS symptoms and their severity in adolescents
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Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-10 Negar Ajabi Ardehjani, Marzieh Agha-Hosseini, Maryam Shabani Nashtaei, Mahshad Khodarahmian, Maryam Shabani, Masoome Jabarpour, Farzane Fereidouni, Tayebeh Rastegar, Fardin Amidi
This study was designed to examine the effect of resveratrol on mitochondrial biogenesis, oxidative stress (OS), and assisted reproductive technology (ART) outcomes in individuals with polycystic ovary syndrome (PCOS). Fifty-six patients with PCOS were randomly assigned to receive 800 mg/day of resveratrol or placebo for 60 days. The primary outcome was OS in follicular fluid (FF). The secondary outcome
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Comprehensive analysis of hub genes associated with cisplatin-resistance in ovarian cancer and screening of therapeutic drugs through bioinformatics and experimental validation J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-10 Yunshan Zhu, Xuehong Chen, Rongrong Tang, Guangxiao Li, Jianhua Yang, Shihao Hong
To identify key genes associated with cisplatin resistance in ovarian cancer, a comprehensive analysis was conducted on three datasets from the GEO database and through experimental validation. Gene expression profiles were retrieved from the GEO database. DEGs were identified by comparing gene expression profiles between cisplatin-sensitive and resistant ovarian cancer cell lines. The identified genes
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Depletion of placental brain-derived neurotrophic factor (BDNF) is attributed to premature ovarian insufficiency (POI) in mice offspring J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-09 Bin Liu, Yongjie Liu, Shuman Li, Pingping Chen, Jun Zhang, Liping Feng
Premature ovarian insufficiency (POI) is one of the causes of female infertility. Unexplained POI is increasingly affecting women in their reproductive years. However, the etiology of POI is diverse and remains elusive. We and others have shown that brain-derived neurotrophic factor (BDNF) plays an important role in adult ovarian function. Here, we report on a novel role of BDNF in the Developmental
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The intratumoral microbiota biomarkers for predicting survival and efficacy of immunotherapy in patients with ovarian serous cystadenocarcinoma J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-05 Hao Qin, Jie Liu, Yi Qu, Yang-Yang Li, Ya-Lan Xu, Yi-Fang Yan
Ovarian serous cystadenocarcinoma, accounting for about 90% of ovarian cancers, is frequently diagnosed at advanced stages, leading to suboptimal treatment outcomes. Given the malignant nature of the disease, effective biomarkers for accurate prediction and personalized treatment remain an urgent clinical need. In this study, we analyzed the microbial contents of 453 ovarian serous cystadenocarcinoma
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Ovarian fibrosis: molecular mechanisms and potential therapeutic targets J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-05 Mengqing Gu, Yibo Wang, Yang Yu
Ovarian fibrosis, characterized by the excessive proliferation of ovarian fibroblasts and the accumulation of extracellular matrix (ECM), serves as one of the primary causes of ovarian dysfunction. Despite the critical role of ovarian fibrosis in maintaining the normal physiological function of the mammalian ovaries, research on this condition has been greatly underestimated, which leads to a lack
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Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-04 Somayeh Ziaei, Motahareh Hasani, Mahsa Malekahmadi, Elnaz Daneshzad, Katayoun Kadkhodazadeh, Javad Heshmati
To investigate whether melatonin supplementation can enhance cardiometabolic risk factors, reduce oxidative stress, and improve hormonal and pregnancy-related factors in patients with PCOS. We conducted a systematic search of PubMed/Medline, Scopus, and the Cochrane Library for articles published in English from inception to March 2023. We included randomized controlled trials (RCTs) on the use of
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Co-administration of GnRH-agonist and hCG (double trigger) for final oocyte maturation increases the number of top-quality embryos in patients undergoing IVF/ICSI cycles J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-03 Binbin Tu, Hua Zhang, Lixue Chen, Rui Yang, Ping Liu, Rong Li, Jie Qiao
The utilization of a double trigger, involving the co-administration of gonadotropin-releasing hormone agonist (GnRH-a) and human chorionic gonadotropin (hCG) for final oocyte maturation, is emerging as a novel approach in gonadotropin-releasing hormone antagonist (GnRH-ant) protocols during controlled ovarian hyperstimulation (COH). This protocol involves administering GnRH-a and hCG 40 and 34 h prior
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Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance J. Ovarian Res. (IF 3.8) Pub Date : 2024-07-02 Liping Hu, Guolin Hong, Jingzhi Li, Mengkun Chen, Chih-Jung Chang, Po-Jen Cheng, Zhimei Zhang, Xinli Zhang, Huiping Chen, Yingting Zhuang, Yuqin Li
This study investigated changes in plasma microbial-derived extracellular vesicles (EVs) in patients with polycystic ovary syndrome and insulin resistance (PCOS-IR) before and after metformin treatment, and aimed to identify bacterial taxa within EVs that were biologically and statistically significant for diagnosis and treatment. The case–control study was conducted at Xiamen Chang Gung Hospital,
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Ultrasonographic and histopathological investigation of the effect of N-acetylcysteine on doxorubicin-induced ovarian and uterine toxicity in rats J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-28 Evren Üstüner, Ebru Yıldırım, Hasan Ceyhun Macun, Hüsamettin Ekici, Yaşar Şahin, Enes Güncüm, Tuğçe Anteplioğlu, Taha Burak Elifoğlu, Esra Bozkaya
This study aimed to investigate the mitigating effect of N-acetylcysteine (NAC) on doxorubicin (DOX)-induced ovarian and uterine toxicity in rats using laboratory tests, ultrasonographic (US) imaging, and histopathology analysis. Forty-eight rats were divided into six groups (n = 8) as follows: Group A (control) (0.5 mL saline administered intraperitoneally [IP]), Group B (a single 10 mg/kg dose of
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Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-28 Sara El Fouikar, Nathalie Van Acker, Virginie Héliès, François-Xavier Frenois, Frank Giton, Véronique Gayrard, Yannick Dauwe, Laila Mselli-Lakhal, Delphine Rousseau-Ralliard, Natalie Fournier, Roger Léandri, Nicolas Gatimel
Industrial progress has led to the omnipresence of chemicals in the environment of the general population, including reproductive-aged and pregnant women. The reproductive function of females is a well-known target of endocrine-disrupting chemicals. This function holds biological processes that are decisive for the fertility of women themselves and for the health of future generations. However, insufficient
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Genomic alteration discordance in the paired primary-recurrent ovarian cancers: based on the comprehensive genomic profiling (CGP) analysis J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-27 Jiayin Dong, Jing Ni, Jiahui Chen, Xuening Wang, Luxin Ye, Xia Xu, Wenwen Guo, Xiaoxiang Chen
Ovarian cancer (OC) is characterized by a high recurrence rate, and homologous recombination deficiency (HRD) is an important biomarker in the clinical management of OC. We investigated the differences in clinical genomic profiles between the primary and platinum-sensitive recurrent OC (PSROC), focusing on HRD status. A total of 40 formalin-fixed paraffin-embedded (FFPE) tissues of primary tumors and
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Single-cell RNA sequencing of human oocytes reveals a differential transcriptomic profile associated with agar-like zona pellucida J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-26 Xiangyang Zhang, Senlin Shi, Ying Wan, Wenyan Song, Haixia Jin, Yingpu Sun
Agar-like zona pellucida (ZP) is the most common type of abnormal ZP, and is one of the causes of low fertility or infertility. However, the molecular mechanism of agar-like ZP is unclear. Single-cell RNA-sequencing (scRNA-seq) analysis was used to assess the cellular and molecular landscape of oocytes with agar-like ZP. Human metaphase I (MI) oocytes were collected from four patients with agar-like
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Predicting CD27 expression and clinical prognosis in serous ovarian cancer using CT-based radiomics J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-22 Chen Zhang, Heng Cui, Yi Li, Xiaohong Chang
This study aimed to develop and evaluate radiomics models to predict CD27 expression and clinical prognosis before surgery in patients with serous ovarian cancer (SOC). We used transcriptome sequencing data and contrast-enhanced computed tomography images of patients with SOC from The Cancer Genome Atlas (n = 339) and The Cancer Imaging Archive (n = 57) and evaluated the clinical significance and prognostic
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Pretreatment with or without GnRH-agonist before frozen–thawed embryo transfer in patients with PCOS: a systematic review and meta-analysis J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-21 Jie Li, Zhong Lin, Sien Mo, Shujia Wang, Yanmei Li, Qiuling Shi
This study was aimed to systematically evaluate the efficacy of artificial cycle-prepared frozen–thawed embryo transfer (FET) with or without gonadotrophin-releasing hormone agonist (GnRH-a) pretreatment for women with polycystic ovary syndrome (PCOS). The analysis was carried out by searching the PubMed, EMBASE, and CNKI databases with a combination of keywords before October 2021. The available studies
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Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis J. Ovarian Res. (IF 3.8) Pub Date : 2024-06-21 Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Yen-Chein Lai
Teratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of teratomas may provide a better understanding of their stepwise differentiation processes and molecular bases, which could prove useful for the development of tissue-engineering technologies. In the present study, we analyzed the copy number aberrations of nine