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EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells J. Ovarian Res. (IF 4.0) Pub Date : 2024-05-08 Yuxi Li, Hsun-Ming Chang, Hua Zhu, Ying-Pu Sun, Peter C. K. Leung
The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating the ovulatory process. Pentraxin 3 (PTX3), an essential ovulatory protein, is necessary for maintaining extracellular matrix (ECM) stability during cumulus expansion. The aim of this study was to investigate the impact of EGF-like factors, AREG
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Fertility-sparing surgery in children and adolescents with borderline ovarian tumors: a retrospective study J. Ovarian Res. (IF 4.0) Pub Date : 2024-05-08 Jiayuan Zhao, Dan Wang, Ruojiao Wang, Yonglan He, Congwei Jia, Lingya Pan, Shuiqing Ma, Ming Wu, Weidi Wang, Xinghan Cheng, Junjun Yang, Yang Xiang
To describe the characteristics of children and adolescents with borderline ovarian tumors (BOTs) and evaluate the efficacy and safety of fertility-sparing surgery (FSS) in these patients. Patients with BOTs younger than 20 years who underwent FSS were included in this study. A total of 34 patients were included, with a median patient age of 17 (range, 3–19) years; 97.1% (33/34) of cases occurred after
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Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study J. Ovarian Res. (IF 4.0) Pub Date : 2024-05-07 Bingrui Gao, Chenxi Zhang, Deping Wang, Bojuan Li, Zhongyan Shan, Weiping Teng, Jing Li
Recent studies have revealed the correlation between serum vitamin D (VD) level and polycystic ovary syndrome (PCOS), but the causality and specific mechanisms remain uncertain. We aimed to investigate the cause-effect relationship between serum VD and PCOS, and the role of testosterone in the related pathological mechanisms. We assessed the causality between serum VD and PCOS by using genome-wide
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NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells J. Ovarian Res. (IF 4.0) Pub Date : 2024-05-04 Cassie Liu, Makenzie Vorderbruggen, Catalina Muñoz-Trujillo, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Adam R. Karpf
Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated the activity of different FOXM1 inhibitors in HGSOC cell models. We treated HGSOC and fallopian tube epithelial (FTE) cells with a panel of previously reported FOXM1 inhibitors. Based on drug potency, efficacy, and selectivity
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Correction: TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2 J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-29 Yali Fan, Shuya Chen, Chunfang Chu, Xiaodan Yin, Jing Jin, Lingyan Zhang, Huihui Yan, Zheng Cao, Ruixia Liu, Mingwei Xin, Lin Li, Chenghong Yin
Correction: J Ovarian Res 17, 67 (2024) https://doi.org/10.1186/s13048-024-01396-2 Following publication of the original article [1], the authors reported that there was an error in the additional file 1 wherein during compilation of the figure, images from incorrect group were inadvertently included in the panel of “TP63-WT+siCLCA2-1”. The correct images were shown below. Incorrect additional file:
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A novel defined programmed cell death related gene signature for predicting the prognosis of serous ovarian cancer J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-29 Feng Zhan, Yina Guo, Lidan He
This study aims to explore the contribution of differentially expressed programmed cell death genes (DEPCDGs) to the heterogeneity of serous ovarian cancer (SOC) through single-cell RNA sequencing (scRNA-seq) and assess their potential as predictors for clinical prognosis. SOC scRNA-seq data were extracted from the Gene Expression Omnibus database, and the principal component analysis was used for
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The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-27 Arash Abdi, Mina Ranjbaran, Fardin Amidi, Fariba Akhondzadeh, Behjat Seifi
The present study aimed to elucidate how mesenchymal stem cells (MSCs) application could efficiently attenuate pathological changes of letrozole-induced poly cystic ovary syndrome (PCOS) by modulating mitochondrial dynamic via PI3K-AKT pathway. Thirty-two female rats were randomly divided into four experimental groups: Sham, PCOS, PCOS + MSCs, and PCOS + MSCs + LY294002. The Sham group received 0.5%
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The association between triglyceride glucose-body Mass Index and in vitro fertilization outcomes in women with polycystic ovary syndrome: a cohort study J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-26 Xin Li, Ting Luan, Yi Wei, JuanJuan Zhang, Chun Zhao, Xiufeng Ling
Polycystic Ovary Syndrome (PCOS) is a common reproductive disorder that frequently affects fertility. The TyG-BMI (Triglyceride glucose-body mass) index is a newly explored parameter that may be linked to reproductive results in individuals with PCOS. Nevertheless, its connection with outcomes in In Vitro Fertilization (IVF) procedures remains uncertain. This study included a total of 966 females who
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Yu Linzhu alleviates primary ovarian insufficiency in a rat model by improving proliferation and energy metabolism of granulosa cells through hif1α/cx43 pathway J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-26 Xin Ruan, Pengxu Wang, Maolin Wei, Qingqing Yang, Xiaoying Dong
Yu Linzhu (YLZ) is a classical Chinese traditional formula, which has been used for more than 600 years to regulate menstruation to help pregnancy. However, the mechanism of modern scientific action of YLZ needs to be further studied. Thirty SD female rats were divided into three groups to prepare the blank serum and drug-containing serum, and then using UHPLC-QE-MS to identify the ingredients of YLZ
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Cardiovascular mortality risk in patients with ovarian cancer: a population-based study J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-25 Ze-Lin Hu, Ying-Xue Yuan, Meng-Yi Xia, Ying Li, Ying Yang, Sheng-Nan Wang, Xuan-Zhu Meng, Mo-Ying Sun, Ning Wang
Ovarian cancer (OC) can occur at different ages and is affected by a variety of factors. In order to evaluate the risk of cardiovascular mortality in patients with ovarian cancer, we included influencing factors including age, histological type, surgical method, chemotherapy, whether distant metastasis, race and developed a nomogram to evaluate the ability to predict occurrence. At present, we have
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Methyl 3,4-dihydroxybenzoate alleviates oxidative damage in granulosa cells by activating Nrf2 antioxidant pathway J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-25 Shishi Li, Yuhang Fan, Chongyi Shu, Yier Zhou, Jing Shu
Oxidative damage induced granulosa cells (GCs) apoptosis was considered as a significant cause of compromised follicle quality, antioxidants therapy has emerged as a potential method for improving endometriosis pregnancy outcomes. Here, we found that GCs from endometriosis patients show increased oxidative stress level. Methyl 3,4-dihydroxybenzoate (MDHB), a small molecule compound that is extracted
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Unravelling driver genes as potential therapeutic targets in ovarian cancer via integrated bioinformatics approach J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-23 Anam Beg, Rafat Parveen, Hassan Fouad, M. E. Yahia, Azza S. Hassanein
Target-driven cancer therapy is a notable advancement in precision oncology that has been accompanied by substantial medical accomplishments. Ovarian cancer is a highly frequent neoplasm in women and exhibits significant genomic and clinical heterogeneity. In a previous publication, we presented an extensive bioinformatics study aimed at identifying specific biomarkers associated with ovarian cancer
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A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-19 Xuhui Dong, Lei Yuan, Ruoyao Zou, Liangqing Yao
Omentectomy is an important procedure in surgery for epithelial ovarian cancer, but the scope of omentectomy is not recommended in the guidelines. This study was performed to evaluate the benefits and risks of infragastric omentectomy in patients with epithelial ovarian cancer. This trial is a single center prospective study. Primary epithelial ovarian cancer patients with normal-appearing omentum
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ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-18 Yuanyuan An, Hua Duan
Macrophages play an essential role in regulating ovarian cancer immune microenvironment. Studies have shown that m6A methylation could influence immune microenvironment in cancer. In this study, we investigated the roles of m6A demethylase ALKBH5 and m6A recognition protein IGF2BP2 played in regulating macrophages polarization in ovarian cancer. In this study, we first explored the differentially expressed
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Comprehensive DNA methylation profiling by MeDIP-NGS identifies potential genes and pathways for epithelial ovarian cancer J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-16 Priyanka Gautam, Sameer Gupta, Manisha Sachan
Ovarian cancer, among all gynecologic malignancies, exhibits the highest incidence and mortality rate, primarily because it is often presents with non-specific or no symptoms during its early stages. For the advancement of Ovarian Cancer Diagnosis, it is crucial to identify the potential molecular signatures that could significantly differentiate between healthy and ovarian cancerous tissues and can
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Integration of single-cell RNA-seq and bulk RNA-seq data to construct and validate a cancer-associated fibroblast-related prognostic signature for patients with ovarian cancer J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-16 Liang Shen, Aihua Li, Jing Cui, Haixia Liu, Shiqian Zhang
To establish a prognostic risk profile for ovarian cancer (OC) patients based on cancer-associated fibroblasts (CAFs) and gain a comprehensive understanding of their role in OC progression, prognosis, and therapeutic efficacy. Data on OC single-cell RNA sequencing (scRNA-seq) and total RNA-seq were collected from the GEO and TCGA databases. Seurat R program was used to analyze scRNA-seq data and identify
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The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-15 A. Conforti, G. G. Iorio, R. Di Girolamo, M. Y. Rovetto, S. Picarelli, F. Cariati, R. Gentile, A. D’Amato, O. Gliozheni, B. Fioretti, C. Alviggi
Resveratrol is a natural polyphenolic compound present in plants and red wine with many potential health benefits. This compound has various anti-inflammatory and anti-tumor properties and can improve cellular mitochondrial activity. This trial was designed to evaluate the effect on the outcome of IVF of Resveratrol supplementation in women > 35 years with good ovarian reserve (AMH > 1.2 ng/ml). Women
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Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-15 Yuan Zhou, Jinfa Huang, Lingling Zeng, Qian Yang, Fangjuan Bai, Qiqing Mai, Kaixian Deng
Chemotherapy exposure has become a main cause of premature ovarian insufficiency (POI). This study aimed to evaluate the role and molecular mechanism of human umbilical cord mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ovarian function protection after chemotherapy. hUMSC-Exos were applied to cyclophosphamide-induced premature ovarian insufficiency mice and human ovarian granulosa tumor cells
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CAPN2 correlates with insulin resistance states in PCOS as evidenced by multi-dataset analysis J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-12 Xi Luo, Yunhua Dong, Haishan Zheng, Xiaoting Zhou, Lujuan Rong, Xiaoping Liu, Yun Bai, Yunxiu Li, Ze Wu
IR emerges as a feature in the pathophysiology of PCOS, precipitating ovulatory anomalies and endometrial dysfunctions that contribute to the infertility challenges characteristic of this condition. Despite its clinical significance, a consensus on the precise mechanisms by which IR exacerbates PCOS is still lacking. This study aims to harness bioinformatics tools to unearth key IR-associated genes
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Assessing the clinical diagnostic value of anti-Müllerian hormone in polycystic ovarian syndrome and its correlation with clinical and metabolism indicators J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-10 Li Wang, Mengjun Luo, Xiaoyu Yu, Rong Li, Fei Ye, Dongsheng Xiong, Yan Gong, Mingyue Zheng, Weixin Liu, Jiuzhi Zeng
This study investigated the association between Anti-Müllerian Hormone (AMH) and relevant metabolic parameters and assessed its predictive value in the clinical diagnosis of polycystic ovarian syndrome (PCOS). A total of 421 women aged 20–37 years were allocated to the PCOS (n = 168) and control (n = 253) groups, and their metabolic and hormonal parameters were compared. Spearman correlation analysis
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Pre-operative plasma VEGF-C levels portend recurrence in epithelial ovarian cancer patients and is a bankable prognostic marker even in the initial assessment of a patient J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-09 J. Bhaskari, Rahul Bhagat, V. Shilpa, C.S. Premalata, Lakshmi Krishnamoorthy
Our explorative study assessed a panel of molecules for their association with epithelial ovarian carcinomas and their prognostic implications. The panel included tissue expression of VEGF-C, COX-2, Ki-67 and eNOS alongside plasma levels of VEGF-C and nitric oxide. 130 cases were enrolled in the study. Plasma levels were quantified by ELISA and tissue expressions were scored by immunohistochemistry
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Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-08 Tarun Kumar Kar, Sananda Sil, Angshita Ghosh, Ananya Barman, Sandip Chattopadhyay
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder in women that necessitates effective and safe treatment alternatives. This study aimed to evaluate the therapeutic efficacy of Vitex negundo seed in a letrozole-induced PCOS rat model. Findings of the present study demonstrated that administration of hydro-ethanolic extract of Vitex negundo (VNE) effectively restored endocrino-metabolic
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The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-04 Na Yin, Chao Luo, Lun Wei, Guangzhao Yang, Le Bo, Caiping Mao
Umbilical cord-derived mesenchymal stem cell (UCMSC) transplantation has been deeply explored for premature ovarian insufficiency (POI) disease. However, the associated mechanism remains to be researched. To explore whether and how the microRNA 21 (miR-21) functions in POI mice with UCMSCs transplantation, the autoimmune-induced POI mice model was built up, transplanted with or without UCMSCs transfect
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Birth weight and premature ovarian insufficiency: a systematic review and meta-analysis J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-03 Chengyang Jiang, Tongqing Gao, Yuwei Wang, Wenqiang Yang, Huan Huang, Yushan Li, Xinghai Yang
To comprehensively evaluate the effect of low birth weight on premature ovarian insufficiency. We performed a systematic review of the literature by searching MEDLINE, EMBASE, Web of Science, Scopus, Wanfang and CNKI up to August 2023. All cohort and case-control studies that included birth weight as an exposure and premature ovarian insufficiency as an outcome were included in the analysis. Data were
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Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-02 Juwon Lee, Suin Jang, Jihye Im, Youngjin Han, Soochi Kim, HyunA Jo, Wenyu Wang, Untack Cho, Se Ik Kim, Aeran Seol, Boyun Kim, Yong Sang Song
Ovarian cancer is a leading cause of death among gynecologic tumors, often detected at advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors driving cancer cell growth. Stearoyl-CoA desaturase 1 (SCD1) is a crucial enzyme involved in de novo lipid synthesis, producing mono-unsaturated fatty acids (MUFAs). Here, we aimed to investigate the expression and significance
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LncRNA SNHG12 promotes cell proliferation and inhibits apoptosis of granulosa cells in polycystic ovarian syndrome by sponging miR-129 and miR-125b J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-02 Feilan Xuan, Ruiying Jin, Weimei Zhou, Yongju Ye, Yuefang Ren, Jiali Lu, Aixue Chen
Polycystic ovarian syndrome (PCOS) is the most common endocrine disease in women of childbearing age which is often associated with abnormal proliferation or apoptosis of granulosa cells (GCs). Studies proved that long non-coding RNA SNHG12 (lncRNA SNHG12) is significantly increased in ovarian cancer and cervical cancer patients and cells. The inhibition of lncRNA SNHG12 restrains the proliferation
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Sialyl-Tn serves as a potential therapeutic target for ovarian cancer J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-02 Linah Al-Alem, Jillian M. Prendergast, Justin Clark, Bianca Zarrella, Dominique T. Zarrella, Sarah J. Hill, Whitfield B. Growdon, Venkatesh Pooladanda, David R. Spriggs, Daniel Cramer, Kevin M. Elias, Rawan I. Nazer, Steven J. Skates, Jeff Behrens, Daniel T. Dransfield, Bo R. Rueda
Ovarian cancer remains the deadliest of the gynecologic cancers in the United States. There have been limited advances in treatment strategies that have seen marked increases in overall survival. Thus, it is essential to continue developing and validating new treatment strategies and markers to identify patients who would benefit from the new strategy. In this report, we sought to further validate
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Subsequent management and outcomes after first-line PARP inhibitors progression in ovarian cancer patients J. Ovarian Res. (IF 4.0) Pub Date : 2024-04-01 Hua Yuan, Ning Li, Lingying Wu, Hongwen Yao
This retrospective study aims to evaluating the subsequent management and outcomes after first-line PARPi progression in Chinese ovarian cancer population. Clinical and pathologic variables, treatment modalities, and outcomes were assessed. We investigated the subsequent management and outcomes after first-line PARPi progression. The objective response rate (ORR) and disease control rate (DCR) parameters
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Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-27 Ping Zhou, Penghui Feng, Baoying Liao, Lin Fu, Hongying Shan, Canhui Cao, Renxin Luo, Tianliu Peng, Fenting Liu, Rong Li
Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and
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CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-27 Qingsong Zhang, Rong Zhang, Yuzhi Li, Xiaojun Yang
The gene cell division cycle associated 5 (CDCA5), also called sororin, has oncogenic characteristics and is upregulated in various carcinomas. Nevertheless, the involvement of CDCA5 in ovarian cancer (OC), a highly aggressive form of cancer, and the underlying mechanism of metastasis remain inadequately investigated. The bioinformatics data revealed a negative correlation between the patient’s survival
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TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2 J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-25 Yali Fan, Shuya Chen, Chunfang Chu, Xiaodan Yin, Jing Jin, Lingyan Zhang, Huihui Yan, Zheng Cao, Ruixia Liu, Mingwei Xin, Lin Li, Chenghong Yin
Premature ovarian insufficiency (POI) is a severe disorder leading to female infertility. Genetic mutations are important factors causing POI. TP63-truncating mutation has been reported to cause POI by increasing germ cell apoptosis, however what factors mediate this apoptosis remains unclear. Ninety-three patients with POI were recruited from Beijing Obstetrics and Gynecology Hospital, Capital Medical
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Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-19 Shih-Yun Chen, Tse-En Wang, Wei-Yun Lee, Ya-Yi Yang, Hong-Chun Lai, Fuko Matsuda, Haruhiko Kosek, You-Tzung Chen, Sheng-Hsiang Li, Pei-Shiue Tsai
Quiescin sulfhydryl oxidase 2 (QSOX2) is a flavin adenine dinucleotide-dependent sulfhydryl oxidase that is known to be involved in protein folding, cell growth regulation, and redox state modification through oxidative activities. Earlier studies demonstrated the tissue and cellular localization of QSOX2 in the male reproductive tract, as well as the highly-regulated mechanism of QSOX2 protein synthesis
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Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-18 Paola Maria da Silva Rosa, Alessandra Bridi, Giuliana de Ávila Ferronato, Cibele Maria Prado, Natália Marins Bastos, Juliano Rodrigues Sangalli, Flávio Vieira Meirelles, Felipe Perecin, Juliano Coelho da Silveira
It is well described that circulating progesterone (P4) plays a key role in several reproductive events such as oocyte maturation. However, during diestrus, when circulating P4 is at the highest concentrations, little is known about its local impact on the follicular cells such as intrafollicular P4 concentration due to corpus luteum (CL) presence within the same ovary. Based on that, our hypothesis
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Identification and validation of IRF6 related to ovarian cancer and biological function and prognostic value J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-16 Shihao Hong, Ni Fu, Shanliang Sang, Xudong Ma, Fangying Sun, Xiao Zhang
Ovarian cancer (OC) is a severe gynecological malignancy with significant diagnostic and therapeutic challenges. The discovery of reliable cancer biomarkers can be used to adjust diagnosis and improve patient care. However, serous OC lacks effective biomarkers. We aimed to identify novel biomarkers for OC and their pathogenic causes. The present study used the differentially expressed genes (DEGs)
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A novel machine-learning framework based on early embryo morphokinetics identifies a feature signature associated with blastocyst development J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-15 S. Canosa, N. Licheri, L. Bergandi, G. Gennarelli, C. Paschero, M. Beccuti, D. Cimadomo, G. Coticchio, L. Rienzi, C. Benedetto, F. Cordero, A. Revelli
Artificial Intelligence entails the application of computer algorithms to the huge and heterogeneous amount of morphodynamic data produced by Time-Lapse Technology. In this context, Machine Learning (ML) methods were developed in order to assist embryologists with automatized and objective predictive models able to standardize human embryo assessment. In this study, we aimed at developing a novel ML-based
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FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-15 Rongli Wang, Feiyan Cheng, Xinyuan Yang
Premature ovarian failure (POF) is a devastating condition for women under 40 years old. Chemotherapy, especially the use of cisplatin, has been demonstrated to promote the apoptosis of granulosa cells in primary and secondary follicles, leading to POF. Our previous studies demonstrated that fat mass- and obesity-associated (FTO) plays an essential role in protecting granulosa cells from cisplatin-induced
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Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1 J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-14 Jiajia Li, Yihua Sun, Xiuling Zhi, Yating Sun, Zulimire Abudousalamu, Qianhan Lin, Bin Li, Liangqing Yao, Mo Chen
Lymph node metastasis (LNM) is a major factor contributing to the high mortality rate of ovarian cancer, making the treatment of this disease challenging. However, the molecular mechanism underlying LNM in ovarian cancer is still not well understood, posing a significant obstacle to overcome. Through data mining from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, we have
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Efficacy and safety of follitropin delta for ovarian stimulation in vitro fertilization/ intracytoplasmic sperm injection cycles: a systematic review with meta-analysis J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-14 Stefano Palomba, Donatella Caserta, Paolo Emanuele Levi-Setti, Andrea Busnelli
Follitropin delta is a novel recombinant follicle stimulating hormone preparation uniquely expressed in a human fetal retinal cell line by recombinant DNA technology. To date, no systematic review was available about the safety and the efficacy of the follitropin delta. The objective of this study was systematically reviewing the available literature and to provide updated evidence regarding the efficacy-safety
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Mucin-producing tumors of the ovary——preoperative differentiation between metastatic ovarian mucinous carcinoma and primary mucinous malignant tumors J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-13 Song-Qi Cai, Min-Rong Wu, Xiao-Liang Ma, Jing-Jing Lu, Jin-Wei Qiang, Yin-Yin Guan, Meng-Su Zeng, Jian-Jun Zhou
To investigate the clinical and magnetic resonance imaging (MRI) features for preoperatively discriminating primary ovarian mucinous malignant tumors (POMTs) and metastatic mucinous carcinomas involving the ovary (MOMCs). This retrospective multicenter study enrolled 61 patients with 22 POMTs and 49 MOMCs, which were pathologically proved between November 2014 to Jane 2023. The clinical and MRI features
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Development and clinical validation of a seven-gene signature based on tumor stem cell-related genes to predict ovarian cancer prognosis J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-13 Guangwei Wang, Xiaofei Liu, Yue You, Silei Chen, Xiaohan Chang, Qing Yang
Tumors are highly heterogeneous, and within their parenchyma, a small population of tumor-stem cells possessing differentiation potential, high oncogenicity, and self-renewal capabilities exists. These cells are pivotal in mediating tumor development, chemotherapy resistance, and recurrence. Ovarian cancer shares characteristics with tumor stem cells, making it imperative to investigate molecular markers
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Mesonephric-like adenocarcinoma of the ovary J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-05 Yun Yang, Mengru Zhao, Qiuchen Jia, Huimin Tang, Tingwei Xing, Yang Li, Bin Tang, Lin Xu, Weiwei Wei, Hong Zheng, Ruxia Shi, Bairong Xia, Jiming Chen
Mesonephric-like adenocarcinoma is a new class of rare subtypes of the female reproductive system. Its clinical symptoms are similar to other types of ovarian tumors. The diagnosis is based on pathological and immunohistochemical methods. The main treatment option is surgery combined with chemotherapy. Few cases have been reported at home and abroad. We reported a case of a 45-year-old woman with a
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Meta-analysis of trigger timing in normal responders undergoing GnRH antagonist ovarian hyperstimulation protocol J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-05 Qijun Xie, Danyu Ni, Sisi Chen, Wenjie Zhang, Jue Wang, Xiufeng Ling, Rong Shen
The first meta-analysis focused only on gonadotropin-releasing hormone (GnRH) antagonists, which helped determine the effect of delay trigger on pregnancy outcomes. To evaluate the impact of delay trigger compared with standard trigger in normal responders undergoing GnRH antagonist protocol in improving pregnancy outcomes. Studies published before April 2023 in PubMed, EMBASE, Cochrane Library, Web
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A real-world study of treatment patterns following disease progression in epithelial ovarian cancer patients undergoing poly-ADP-ribose polymerase inhibitor maintenance therapy J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-05 Nan Zhang, Hong Zheng, Yunong Gao, Tong Shu, Hongguo Wang, Yan Cai
The efficacy of subsequent therapy after poly-ADP-ribose polymerase (PARP) inhibitor maintenance treatment has raised concerns. Retrospective studies show worse outcomes for platinum-based chemotherapy after progression of PARP inhibitor-maintenance therapy, especially in BRCA-mutant patients. We aimed to describe subsequent therapy in ovarian cancer patients after PARP inhibitor-maintenance therapy
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Meiotic and developmental competence of growing pig oocytes derived from small antral follicles is enhanced in culture medium containing FGF2, LIF, and IGF1 (FLI medium) J. Ovarian Res. (IF 4.0) Pub Date : 2024-03-02 Alexandra Rosenbaum Bartková, Lucie Němcová, Veronika Kinterová, Dominika Radová, František Strejček, Tereza Toralová, Jozef Laurinčík, Radek Procházka
Oocytes of large animal species isolated from small ovarian follicles (< 2 mm) are less competent to support early embryonic development after in vitro maturation and fertilization than their counterparts isolated from medium-sized and preovulatory follicles. This study aimed to assess the effect of a new maturation medium containing FGF2, LIF, and IGF1 (FLI medium) on the meiotic and developmental
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PARP inhibitor era in ovarian cancer treatment: a systematic review and meta-analysis of randomized controlled trials J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-26 István Baradács, Brigitta Teutsch, Alex Váradi, Alexandra Bilá, Ádám Vincze, Péter Hegyi, Tamás Fazekas, Balázs Komoróczy, Péter Nyirády, Nándor Ács, Ferenc Bánhidy, Balázs Lintner
Ovarian cancer is the eighth leading cause of cancer-related death among women, characterized by late diagnosis and a high relapse rate. In randomized controlled trials, we aimed to evaluate the efficacy and safety of PARP inhibitors (PARPi) in treating advanced ovarian cancer. This review was registered on PROSPERO (CRD42021283150), included all phase II and phase III randomized controlled trials
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The miR-1290/OGN axis in ovarian cancer-associated fibroblasts modulates cancer cell proliferation and invasion J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-24 Biyao Jiang, Songshu Xiao, Shan Zhang, Fang Xiao
Despite receiving first-line treatment, ovarian cancer patients continue to experience a high rate of recurrence; nearly all women with ovarian cancer develop chemoresistance and succumb to the disease. In this study, cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) were isolated from tumor-containing and normal omenta, respectively, and the downregulation of osteoglycin (OGN) in CAFs
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Effect of repeated vitrification of human embryos on pregnancy and neonatal outcomes J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-24 Yan Huang, Yi Cheng, Min Zhang, Yiqing Chen, Rong Zhou, Dewei Lin, Xinyu Guo
Repeated cryopreservation of embryos should occasionally be considered when embryos were not suitable for transfer. The effect of re-cryopreservation on embryos remains contentious. This retrospective cohort study aimed to evaluate the pregnancy and neonatal outcomes of twice vitrificated blastocyst derived from once vitrified embryos. Total 410 vitrified-warmed blastocyst transfer cycles were divided
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Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-23 Hao Wang, Yin-hai Xu, Yi Guo
Individual patients with ovarian cancer show remarkably different prognosis. Present prognostic models for ovarian cancer mainly focus on clinico-pathological parameters, so quantifiable prognostic markers at molecular level are urgently needed. Platelets contribute to ovarian cancer progression, but have not been considered as biomarkers likely due to their instability. Here, we aimed to search for
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Synergistic suppression of ovarian cancer by combining NRF2 and GPX4 inhibitors: in vitro and in vivo evidence J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-23 Ning Li, Xingmei Jiang, Qingyu Zhang, Yongmei Huang, Jinbin Wei, Haitao Zhang, Hui Luo
Ovarian cancer is a significant challenge in women's health due to the lack of effective screening and diagnostic methods, often leading to late detection and the highest mortality rate among all gynecologic tumors worldwide. Recent research has shown that ovarian cancer has an "iron addiction" phenotype which makes it vulnerable to ferroptosis inducers. We tested the combination of NRF2-targeted inhibitors
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Development and validation of an ultrasound‑based radiomics nomogram to predict lymph node status in patients with high-grade serous ovarian cancer: a retrospective analysis J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-22 Yue Qi, Jinchi Liu, Xinyue Wang, Yuqing Zhang, Zhixun Li, Xinyu Qi, Ying Huang
Despite advances in medical imaging technology, the accurate preoperative prediction of lymph node status remains challenging in ovarian cancer. This retrospective study aimed to investigate the feasibility of using ultrasound-based radiomics combined with preoperative clinical characteristics to predict lymph node metastasis (LNM) in patients with high-grade serous ovarian cancer (HGSOC). Patients
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The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-21 Haijing Zhao, Keer Gan, Xiaohui Ji, Lingyan Zheng, Songbang Ou, Mei Mei, Qingxue Zhang, Hui Chen, Ping Yuan, Wenjun Wang
Evidence from the Istanbul consensus workshop suggests correlations between morphological parameters and embryo developments. 8-cell embryos are the best blastomere stage on day 3. No good quality evidence exists to support high-quality embryonic selection following blastulation and clinical outcomes. This study aimed to investigate the factors that affect blastocyst formation, blastocyst quality,
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Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-20 Hangqi Hu, Jiacheng Zhang, Xiyan Xin, Yuxin Jin, Yutian Zhu, Haolin Zhang, Ruiwen Fan, Yang Ye, Dong Li
This study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF). We conducted comprehensive literature searches and identified relevant studies that examined the protective effects of natural products on experimental POF. We extracted quantitative data on various aspects such as follicular development, ovarian function, physical indicators, oxidative
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An integrated machine learning-based model for joint diagnosis of ovarian cancer with multiple test indicators J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-20 Yiwen Feng
To construct a machine learning diagnostic model integrating feature dimensionality reduction techniques and artificial neural network classifiers to develop the value of clinical routine blood indexes for the auxiliary diagnosis of ovarian cancer. Patients with ovarian cancer clearly diagnosed in our hospital were collected as a case group (n = 185), and three groups of patients with other malignant
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High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-19 Jingyu Liu, Jie Li, Xin Wu, Mei Zhang, Guijun Yan, Haixiang Sun, Dong Li
Polycystic ovary syndrome (PCOS) is one of the most complex endocrine disorders in women of reproductive age. Abnormal proliferation of granulosa cells (GCs) is an important cause of PCOS. This study aimed to explore the role of fatty acid-binding protein 5 (FABP5) in granulosa cell (GC) proliferation in polycystic ovary syndrome (PCOS) patients. The FABP5 gene, which is related to lipid metabolism
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Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-19 Yan Yan, Fangfang Di, Ruoxi Zhang, Liwen Song, Runjie Zhang, Jin Qiu
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) transplantation has been shown to be effective in treating PCOS rats. The study demonstrated that BAT successfully recovered the reproductive and metabolic phenotype of PCOS rats. The disorder
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Metformin versus metformin plus pioglitazone on gonadal and metabolic profiles in normal-weight women with polycystic ovary syndrome: a single-center, open-labeled prospective randomized controlled trial J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-19 Han Zhao, Jiaqi Zhang, Chuan Xing, Xiangyi Cheng, Bing He
To investigate the effects of metformin (MET) monotherapy and pioglitazone plus MET (PIOMET) therapy on gonadal and metabolic profiles in normal-weight women with polycystic ovary syndrome (PCOS). Sixty normal-weight women with PCOS were recruited between January and September 2022 at the Shengjing Hospital of China Medical University. They were randomly assigned to the MET or PIOMET groups for 12
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Structural basis for antibody recognition of the proximal MUC16 ectodomain J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-19 Kwangkook Lee, Kay Perry, Mengyao Xu, Irva Veillard, Raj Kumar, Thapi Dharma Rao, Bo R Rueda, David R Spriggs, Oladapo O Yeku
Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodular fragments, the shed tandem repeat sequence which circulates as a protein bearing the ovarian cancer biomarker (CA125) and a proximal membrane-bound component which is critical in MUC16 oncogenic
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Cai’s prescription inhibits granulosa cell apoptosis through ARHGAP4 on poor ovarian responders J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-14 Zheng Wang, Denghao Liu, Yonghong Nie, Qinhua Zhang
Poor ovarian response (POR) is a big challenge for in vitro fertilization. The traditional Chinese medicine, Cai’s Prescription of Tonifying Kidney and Strengthening Vitals (Cai’s Prescription) has yielded satisfactory results for POR treatment clinically, but systematic scientific research of Cai’s Prescription is not well reported. This study aimed to investigate the clinical effect of Cai’s Prescription
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From clinical management to personalized medicine: novel therapeutic approaches for ovarian clear cell cancer J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-12 Zesi Liu, Chunli Jing, Fandou Kong
Ovarian clear-cell cancer is a rare subtype of epithelial ovarian cancer with unique clinical and biological features. Despite optimal cytoreductive surgery and platinum-based chemotherapy being the standard of care, most patients experience drug resistance and a poor prognosis. Therefore, novel therapeutic approaches have been developed, including immune checkpoint blockade, angiogenesis-targeted
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Knowledge graph construction based on granulosa cells transcriptome from polycystic ovary syndrome with normoandrogen and hyperandrogen J. Ovarian Res. (IF 4.0) Pub Date : 2024-02-12 Wensu Liu, Tianyu Tang, Jianwei Feng, Chunyu Wang, Lin Lin, Shengli Wang, Kai Zeng, Renlong Zou, Zeyu Yang, Yue Zhao
PCOS is a widespread disease that primarily caused in-pregnancy in pregnant-age women. Normoandrogen (NA) and Hyperandrogen (HA) PCOS are distinct subtypes of PCOS, while bio-markers and expression patterns for NA PCOS and HA PCOS have not been disclosed. We performed microarray analysis on granusola cells from NA PCOS, HA PCOS and normal tissue from 12 individuals. Afterwards, microarray data were