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Quantitative characterization of eosinophilia in nasal polyps with AI-based single cell classification. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-20 Martin Stampe,Ida Skovgaard Christiansen,Vibeke Backer,Kasper Aanæs,Anne-Sophie Homøe,Jens Tidemandsen,Emilie Neumann Nielsen,Sigrid Louise Hjorth Rasmussen,Rasmus Hartvig,Katalin Kiss,Thomas Hartvig Lindkær Jensen
Eosinophilic granulocytes have characteristic morphological features. This makes them prime candidates for utilization of a single cell binary classification network. Single cell binary classification networks can reliably help quantify eosinophils in nasal polyps.
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A cost utility analysis for the management of acute exacerbations of chronic rhinosinusitis. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-20 Matthew M Chu,Jack T Garcia,Ahmad R Sedaghat,George A Scangas,Katie M Phillips
BACKGROUND The management of acute exacerbations of chronic rhinosinusitis (AECRS) is understudied and the most cost-effective management of AECRS has not been previously investigated. The aim of this study is to determine the most cost-effective strategy for the initial management of AECRS. METHODS The study design consisted of a decision-tree economic model comparing three different initial strategies
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Reply to correspondence regarding the article "The relationship between survey-based subjective olfactory awareness and objective olfactory function". Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-20 Aurelia S Monk,Shreyas Pyati,Meredith Lamb,Nicholas Melott,Ezer H Benaim,Christopher Wiesen,Cristine Klatt-Cromwell,Brian D Thorp,Charles S Ebert,Adam J Kimple,Brent A Senior
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Rheumatic adverse events associated with biologic therapy for chronic rhinosinusitis: A systematic review and meta-analysis. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-20 Jenny B Xiao,Helen Hsiao,Carlos Khalil,John M Lee
BACKGROUND Biologic therapies approved for treating chronic rhinosinusitis with nasal polyps (CRSwNP) have well-established safety profiles but reports of rheumatic adverse events (AEs) are increasing and not well defined. This review aims to assess the risk and incidence of rheumatic AEs associated with biologic therapy in CRSwNP and summarize current reported management strategies. METHODS A protocol
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Correspondence for article titled "The relationship between survey-based subjective olfactory awareness and objective olfactory function". Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-20 Hyun Jin Min
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In office sampling of eosinophil peroxidase to diagnose eosinophilic chronic rhinosinusitis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-13 Jacquelyn K. Callander, Annabelle R. Charbit, Kritika Khanna, John V. Fahy, Monica Tang, Maude Liegeois, Steven D. Pletcher, Andrew N. Goldberg, Jose G. Gurrola, Andrew H. Murr, Anna Butrymowicz, Patricia A. Loftus
BackgroundPractical biomarkers for endotypic characterization of chronic rhinosinusitis (CRS) remain elusive, hindering clinical utility. Eosinophil peroxidase (EPX) is an enzyme released by activated eosinophils. The objective of this study was to evaluate a clinic EPX assay as a marker of eosinophilic CRS.MethodsSubjects with and without CRS presenting to a tertiary care rhinology clinic were prospectively
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Patient‐reported disease control versus overall symptom severity as global metrics of chronic rhinosinusitis disease status Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-13 Ryan A. Cotter, Jack T. Garcia, Ahmed Alsayed, Sven Schneider, David T. Liu, Julia Eckl‐Dorna, Firas A. Houssein, Robby S. Boparai, Nikhil A. Parail, Matthew M. Chu, Josh C. Meier, Saad Alsaleh, Katie M. Phillips, Ahmad R. Sedaghat
BackgroundOverall symptom severity (OSS) and patient‐reported chronic rhinosinusitis (CRS) control are global measures of CRS identified as consensus, essential criteria for CRS disease control assessment. We sought to determine the functional relationship between these two metrics.MethodsUsing an international multicenter mixed‐methods design, 260 CRS patients were recruited. OSS score was measured
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Age‐related differences in olfactory training outcomes: A prospective cohort study Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-12 Amelia S. Lawrence, Jodi Veach, Rahul Alapati, Celina G. Virgen, Robert Wright, Frank Materia, Jennifer A. Villwock
IntroductionWhile olfactory function decreases with age, it is unknown how age affects olfactory training (OT) efficacy. This study compared OT in two cohorts of subjects: aged ≤50 (younger cohort) and aged 51+ (older cohort) with olfactory dysfunction (OD) primarily from COVID‐19 infection.MethodsSubjects with OD primarily secondary to COVID‐19 infection were prospectively recruited and enrolled into
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Assessing adequacy of surgical extent in CRSwNP: The Completion of Surgery Index Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-12 Alan D. Workman, Krithika Kuppusamy, David K. Lerner, John V. Bosso, Jennifer E. Douglas, Michael A. Kohanski, Nithin D. Adappa, James N. Palmer
BackgroundEndoscopic sinus surgery (ESS) maximized for topical steroid irrigations is highly effective for polyp disease. As extent and completeness of ESS varies widely by situation and practitioner, it is important to understand when revision surgery is appropriate, particularly in the era of biologic treatments.MethodsA Completion of Surgery Index (CoSI) was developed to assess operative changes
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A prospective longitudinal study assessing the impact of rhinovirus and bacterial infections in acute exacerbations of chronic rhinosinusitis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-03 Nirushan Narendran, Sophia Volpe, Ibrahim Ramadan, Jacob Ryan Herbert, Bonnie LaFleur, Shireen Samargandy, Christopher H. Le, Eugene H. Chang
BackgroundAcute exacerbations of chronic rhinosinusitis (AECRS) are thought to arise from common viral infections progressing to secondary bacterial infections. However, the pathophysiology of AECRS remains poorly understood due to a lack of prospective longitudinal studies.MethodsWe conducted a one‐year prospective longitudinal study involving chronic rhinosinusitis (CRS) adults. At baseline, we assessed
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Use of bovine‐derived collagen matrix in the surgical treatment of empty nose syndrome Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-03 Brian H. Cameron, Jason Talmadge, Martin J. Citardi
Key points Bovine‐derived collagen matrix (BDCM) is a safe augmentation material in patients with empty nose syndrome. BDCM augmentation results in clinically and statistically significant improvement in nasal symptoms. Improvements in nasal symptoms with BDCM augmentation may be durable and can be seen up to 2 years postoperative.
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A response to Min et al. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-02 David R. Grimm, Z. Jason Qian, Michael Yong, Peter H. Hwang
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Assessment of conflicts of interest in literature on monoclonal antibodies for chronic rhinosinusitis with nasal polyposis using the Open Payments Database Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-02 Christina Liu, Conrad W. Safranek, Rhys Richmond, Trinithas Boyi, Zachary Pickell, Ryan Rimmer, R. Peter Manes
BackgroundAccurate conflict of interest (COI) information is essential for promoting transparency and trust in research. We aim to assess COI disclosure patterns in monoclonal antibodies (MABs) research for chronic rhinosinusitis with nasal polyposis (CRSwNP) using the Open Payments Database (OPD).MethodsStudies on FDA‐approved MABs for CRSwNP (dupilumab, omalizumab, mepolizumab) published between
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Correspondence to the editor regarding the article entitled, “The effect of PM2.5 on acute sinusitis: A population‐based study” Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-09-02 Hyun Jin Min
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Evaluation of antibiofilm agents for treatment of cystic fibrosis‐related chronic rhinosinusitis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-30 Saartje Uyttebroek, Lieven Dupont, Jeroen Wagemans, Rob Lavigne, Maya Merabishvili, Tom Coenye, Laura Van Gerven
Key points Treatment of cystic fibrosis‐related chronic rhinosinusitis should target sinonasal biofilms. NaHCO3 salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not. Phage effectivity varies and depends on the phage and the combination with antibiotics.
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Functional and radiological sinonasal outcomes of CFTR modulators for sinus disease in cystic fibrosis: A meta‐analysis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-30 Tristan Tham, Felisha A. Li, Jacob R. Schneider, Matthew I. Saleem, Michael T. Werner, Mark B. Chaskes, Charles C. L. Tong, Judd H. Fastenberg
BackgroundCystic fibrosis transmembrane conductance regulator (CFTR) modulators improve pulmonary outcomes in cystic fibrosis (CF) by stabilizing the CFTR protein on respiratory epithelial surfaces. To determine the efficacy of CFTR modulators on sinonasal outcomes in patients with CF, we performed a meta‐analysis of clinical trials to date that include functional and radiographic evidence of sinus
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Generic competition and prices for azelastine‐fluticasone nasal spray Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-30 Akash M. Bhat, Zachary M. Soler, Rodney J. Schlosser, George A. Scangas, Alan D. Workman, Vinay K. Rathi
Key points The original manufacturer of azelastine‒fluticasone (AZ‒FL) prevented generic availability until 2020 via patent enforcement. Following generic availability of AZ‒FL, Medicare utilization increased and spending decreased. Retail prices for generic AZ‒FL remain high due to markup by manufacturers and pharmacies.
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The effect of open‐label placebo on allergic rhinitis symptoms: A systematic review and meta‐analysis of randomized controlled trials Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-30 Ebraheem Albazee, Abdullah M. Alharran, Mooza M. Alzayed
Key points The evidence regarding the open‐label placebo effect on allergic rhinitis symptoms remains uncertain. Open‐label placebo significantly reduced the frequency of symptoms in allergic rhinitis patients with similar safety profiles; however, there was no effect on the severity of symptoms and impairment due to symptoms. The statistically significant impact on symptom frequency can be considered
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CPAP‐induced sphenoid sinus pressures after endoscopic sinus surgery Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-30 Glen E. D'Souza, Alexander Duffy, Shreya Mandloi, Emily Garvey, Bita Naimi, Paavali Hannikainen, Peter Benedict, Gurston N. Nyquist, Christopher Farrell, Marc Rosen, Elina Toskala, James Evans, Mindy R. Rabinowitz
Key Points Positive pressure transmitted from continuous positive airway pressure (CPAP) to the sinuses and skull base in the early post‐operative period has not been studied in live subjects and controversy exists in when to restart this post‐operatively. This study found that approximately 32.76% and 13.52% of the delivered CPAP pressures reached the post‐surgical sphenoid sinus and the mid‐nasal
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Comparative analysis of traditional machine learning and automated machine learning: advancing inverted papilloma versus associated squamous cell carcinoma diagnosis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-26 Farideh Hosseinzadeh, S. Saeed Mohammadi, James N. Palmer, Michael A. Kohanski, Nithin D. Adappa, Michael T. Chang, Peter H. Hwang, Jayakar V. Nayak, Zara M. Patel
Key Points Inverted papilloma conversion to squamous cell carcinoma is not always easy to predict. AutoML requires much less technical knowledge and skill to use than traditional ML. AutoML surpassed the traditional ML algorithm in differentiating IP from IP‐SCC.
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Letter to the editor regarding “The association between olfactory subdomains and frailty: A prospective case‒control study investigation” Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-26 Le Xu, WenJie Zheng, JiaLin Feng, QinYi Zhou, Jun Chen
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EDS‐FLU efficacy in patients with chronic rhinosinusitis with or without prior sinus surgery in ReOpen1 and ReOpen2 randomized controlled trials Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-26 Sarah K. Wise, Nithin D. Adappa, Rakesh K. Chandra, Greg E. Davis, Mahboobeh Mahdavinia, Ramy Mahmoud, John Messina, James N. Palmer, Zara M. Patel, Anju T. Peters, Rodney J. Schlosser, Raj Sindwani, Zachary M. Soler, Andrew A. White
BackgroundThe inability of topical medications to reach sinus cavities is a potential reason for lack of efficacy in chronic rhinosinusitis (CRS). One purpose of endoscopic sinus surgery (ESS) is to enable delivery of medications into the sinus cavities. The exhalation delivery system with fluticasone (EDS‐FLU; XHANCE) creates unique biomechanics that enable deposition of intranasal corticosteroid
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The impact of cadaveric donor transplant on the development of chronic rhinosinusitis and recalcitrant disease Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-24 Estephania Candelo, Anyull D. Bohorquez‐Caballero, Karol Avila‐Castano, Hani Wadei, Angela M Donaldson
Key points The study found a higher incidence of chronic rhinosinusitis (CRS) and recalcitrant CRS in cadaveric organ transplant recipients compared to those receiving living donor transplants. Recipients of cadaveric transplants were 1.32 times more likely to develop CRS and 1.68 times more likely to develop medically recalcitrant CRS. Living kidney transplants significantly reduced the risk of developing
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Letter to the editor regarding “Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma”: The utility of topical cidofovir Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-23 Briana R. Halle, Edward C. Kuan, Melissa Shive
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Reply to: "Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma": The utility of topical cidofovir. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-20 Florian Chatelet,Alessandro Vinciguerra,Morgane Marc,Benjamin Verillaud,Philippe Herman
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Role of induction chemotherapy in advanced-stage olfactory neuroblastoma. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-20 Sung-Woo Cho,Bhumsuk Keam,Keun-Wook Lee,Ji-Won Kim,Doo Hee Han,Hyun Jik Kim,Jeong-Whun Kim,Dong-Young Kim,Chae-Seo Rhee,Yun Jung Bae,Ji-Hoon Kim,Keun-Yong Eom,Hong-Gyun Wu,Yong Hwy Kim,Chae-Yong Kim,Sun Ha Paek,Hyojin Kim,Tae-Bin Won
OBJECTIVES To evaluate the treatment outcomes in patients with advanced-stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC). MATERIALS AND METHODS The clinical data of 38 patients with advanced-stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.1. Patients with complete remission
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Interpretability of operative and pathological reports for radiotherapy planning of sinonasal carcinomas: An ancillary study of the GORTEC 2016-02 SANTAL trial. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-20 Coline Labarre,Florent Carsuzaa,Maxime Fieux,Benjamin Verillaud,Antoine Moya Plana,Ludovic de Gabory,Vincent Patron,Francois-Régis Ferrand,Juliette Thariat
Interpretation of surgical mapping is essential for postoperative radiotherapy planning. Operative and pathological reports lack comprehensive information on margins quality and tissue block mapping. Standardizing reports is essential to reduce uncertainties, aiming for less morbid poRT.
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Reply to: Confounders in the association between olfactory subdomains and frailty. Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-20 Michael Z Cheng,Varun Vohra,Hang Wang,Akhil Katuri,Jackie Langdon,Qian-Li Xue,Nicholas R Rowan
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Oxymetazoline as a predictor of turbinate reduction surgery outcomes: Objective support from a prospective, single‐blinded, computational fluid dynamics study Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-12 Zachary T. Root, Zhenxing Wu, Thomas J. Lepley, Aspen R. Schneller, Robbie J. Chapman, Veronica L. Formanek, Kathleen M. Kelly, Bradley A. Otto, Kai Zhao
BackgroundA patient's subjective response to topical nasal decongestant is often used to screen for turbinate reduction surgery suitability. However, this anecdotal strategy has not been objectively and quantitatively evaluated.MethodsProspective, longitudinal, and single‐blinded cohort study employing computational fluid dynamic modeling based on computed tomography scans at baseline, 30 min postoxymetazoline
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Nasal virus infection induces asthma exacerbation through B‐cell‐dependent recruitment of inflammatory monocytes Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-07 Kody A. Waldstein, Arman Issimov, Maria Ganama, Valerie Jinge, Stephen Tilley, Xiaoyang Hua
BackgroundUpper respiratory viral infections (URVIs) are responsible for 80% of asthma exacerbation episodes. However, the underlying mechanisms remain poorly understood.MethodsIn this study, we used a mouse model of URVI and examined the impact of URVI on asthma phenotypes and the underlying mechanisms.ResultsPreviously, we have reported that nasal‐restricted infection with respiratory syncytial virus
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Rate of dupilumab use and symptom severity of patients with chronic rhinosinusitis with nasal polyposis after Draf 3 frontal sinusotomy Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-07 Keven Ji, Hunter Kellerman, Jess C. Mace, Timothy L. Smith, Kara Y. Detwiller, Shyam R. Joshi, Mathew Geltzeiler
BackgroundThe indications for endoscopic modified Lothrop procedure (Draf 3) in patients with refractory chronic rhinosinusitis with nasal polyposis (CRSwNP) remain unclear. This study evaluates the effectiveness of Draf 3 for refractory CRSwNP focusing on improvements in disease severity and need for subsequent dupilumab rescue therapy.MethodsRetrospective review of patients with CRSwNP undergoing
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Post‐operative outcomes of primary benign orbital tumor resection are independent of tumor size and morphology Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-07 Angela S. Zhu, Ryan A. Bartholomew, Yan Zhao, Margaret B. Mitchell, Benjamin S. Bleier, Barak Ringel
Key points Using 3D modeling, we studied the influence of orbital tumor morphology on post‐operative outcomes. Orbital tumor volume did not influence postoperative complication rates. Less spherical tumors may be correlated with a more extensive surgical approach.
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Identification and characterization of microplastics in human nasal samples Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-07 Hyun Jin Min, Kyung Soo Kim, Hyunjung Kim, Jiyoung Gong, Jinyoung Jeong
KEY POINTS Human nasal cavity samples were collected, and presence of microplastics were evaluated. Microplastics were present, and major types were polyethylene, polyester, acrylic polymer, and polypropylene. Further research is needed regarding microplastics and its clinical impact on human nasal cavity.
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Co‐prevalence of chronic rhinosinusitis and inflammatory bowel disease: A large aggregated electronic health record study Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-08-05 Ravi Dhamija, Peng Ding, Nikita Das, Varunil N. Shah, David C. Kaelber, Mohamad R. Chaaban
Key points IBD patients have a 4.04‐fold elevated likelihood of having CRS compared to non‐IBD patients. CRS patients have a 4.23‐fold elevated likelihood of having IBD compared to non‐CRS patients. The risk of CRS development after IBD is five times higher than IBD development after CRS.
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The placebo effect of sham rhinologic procedures in randomized controlled trials: A systematic review and meta‐analysis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-31 Neil P. Monaghan, Kelsey A. Duckett, Shaun A. Nguyen, Abigail A. Massey, Vinay Rathi, Zachary M. Soler, Rodney J. Schlosser
Key points Sham procedures produce a clinically significant impact on patient‐reported outcome measures This effect should be considered when designing and interpreting the results of RCTs
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Role of social determinants of health on quality of life in pediatric chronic rhinosinusitis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-31 Ryan S. Ziltzer, Sameer Shetty, Dominic Coutinho, Rafka Chaiban, Chadi A. Makary
Key points Social determinants of health link to worse quality of life in pediatric chronic rhinosinusitis. The area deprivation index (ADI) may serve to predict health disparities in these patients.
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Transsphenoidal retrieval of a needlefish beak remnants from the optic canal Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-26 Firas Sbeih, Henry W. Zhou, Noel F. Ayoub, Barak Ringel, Carolina A. Chiou, Joseph F. Rizzo, Benjamin S. Bleier
Key Points Penetrating orbital trauma from marine creatures, especially needlefish, should be considered after injuries sustained in open water. Advances in endoscopic sinus surgery have enabled surgeons to remove certain orbital foreign bodies through endoscopic endonasal approaches. 3D segmentation is a valuable pre‐operative tool in complex endoscopic orbital cases.
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Response to the editor regarding “An eosinophil peroxidase activity assay predicts acute exacerbations in post‐operative chronic rhinosinusitis” Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-25 Abigail Pulsipher, Kristine A. Smith, Richard R. Orlandi, Conner J. Massey, Jeremiah A. Alt, Gretchen M. Oakley, Shaelene Ashby
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Histopathologic evaluation of Asian‐American patients with chronic rhinosinusitis with nasal polyps Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-24 Arthur W. Wu, Kevin Hur, Aria Jafari, Omar G. Ahmed, Philip G. Chen, Masayoshi Takashima, Elena E. Chang, Bonnie Balzer, Anna Matthew, Haodong Xu, Mukul Divatia, Benjamin Tam, Juliana Robledo, Luv Amin, David J. Cvancara, Amisheila Kinua, Tariq A. Syed, Dominique L. Paderin, Dennis M. Tang
Key points Asian‐American (AA) patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have comparable rates of tissue eosinophilia compared to Caucasians when defined as >10 eosinophils/high‐powered field (HPF). AA patients with CRSwNP have significantly higher incidence of mixed inflammation defined as >10 eosinophils/HPF and >10 neutrophils/HPF.
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Diagnostic criteria for eosinophilic chronic rhinosinusitis: Comparative analysis and novel scoring system Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-23 Jae Yoon Lee, Do Hyun Kim, Sung Won Kim, Yeon Hee Im, Chan Soon Park, Dong Hyun Kim, Zainab Alkhars, Soo Whan Kim
BackgroundAccurate identification of eosinophilic chronic rhinosinusitis is essentialg because its treatment and prognosis substantially differ from other subtypes.MethodsThis retrospective observational study included 640 patients who underwent endoscopic sinus surgery for chronic rhinosinusitis in a single tertiary center from January 2021 to December 2022. Receiver operating characteristic curves
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Longer‐term surveillance imaging and endoscopy critical for majority of patients in detection of sinonasal malignancy recurrence Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-23 Catherine Kwiecien, Alan D. Workman, Jadyn Wilensky, David K. Lerner, Vinay K. Rathi, Jennifer E. Douglas, Michael A. Kohanski, Edward C. Kuan, James N. Palmer, Nithin D. Adappa
BackgroundSinonasal malignancy surveillance paradigms are often based on Head and Neck National Comprehensive Cancer Network guidelines, which do not recommend standard surveillance imaging beyond 6 months without concerning symptomatology or physical examination findings.MethodsThis was a retrospective analysis of all patients who underwent resection of sinonasal malignancy at a tertiary care center
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Efficacy of acupuncture for allergic rhinitis in children: Systematic review and meta‑analysis with trial sequential analysis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-17 Qinwen Xiao, Zhichao Ni, Rongyu Wang, Wen Jiang, Jinyao Yuan
BackgroundAcupuncture has been shown for the treatment of allergic rhinitis in previous studies. Nevertheless, relevant evidence was lacked for paediatric patients with allergic rhinitis. We aim to validate the efficacy of acupuncture for allergic rhinitis in children by meta‐analysis and trial sequence analysis.MethodComprehensive search of eight databases were conducted until August 27, 2023. Randomized
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V‐Y advancement flap for the repair of localized cutaneous defects following nasal closure in severe hereditary hemorrhagic telangiectasia Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-16 Guled M. Jama, Simon Gane
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A methodological pipeline for the preclinical evaluation of novel topical agents for the treatment of CRS Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-16 Samuel J. M. Hale, Christian A. Lux, James E. Willoughby, Arne Koefoed, David Broderick, Kristi Biswas, Raymond Kim, Brett Wagner Mackenzie, Richard G. Douglas
Key points Novel topical therapeutics require extensive pre‐clinical testing to assess efficacy and safety. Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity. Agents that are found to be effective and non‐toxic ex vivo warrant further investigation in vivo.
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Gender‐based linguistic differences in letters of recommendation for rhinology fellowship over time: A dual‐institutional follow‐up study using natural language processing and deep learning Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-16 Vikram Vasan, Christopher P. Cheng, Shaun Edalati, Shreya Mandloi, David K. Lerner, Anthony Del Signore, Madeleine Schaberg, Satish Govindaraj, Mindy Rabinowitz, Gurston Nyquist, Alfred Marc Iloreta
Key points This follow‐up dual‐institutional and longitudinal study further evaluated for underlying gender biases in LORs for rhinology fellowship. Explicit and implicit linguistic gender bias was found, heavily favoring male applicants
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There is no sinus without “us”: A randomized controlled study assessing the efficacy of shared decision‐making in the surgical management of chronic rhinosinusitis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-16 Vivienne Li, Andrew Yousef, Divya Prajapati, Michael Oca, Leslie Gomez, Adam S. DeConde, Carol H. Yan
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American Rhinologic Society expert practice statement part 2: Postoperative precautions and management principles following endoscopic skull base surgery Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-12 Jennifer E. Douglas, Nithin D. Adappa, Garret Choby, Corinna G. Levine, Mindy R. Rabinowitz, Raj Sindwani, Eric W. Wang, Bradford A. Woodworth, Edward C. Kuan
The goal of this American Rhinologic Society expert practice statement (EPS) is to summarize the best available evidence regarding postoperative precautions for patients following endoscopic skull base surgery for intradural pathology. These topics include the administration of postoperative nasal hygiene; patient mobilization and activity level; the resumption of continuous positive airway pressure
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American Rhinologic Society Expert Practice Statement: Indications and Recommendations for Septoplasty in Children Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-12 Austin S. Rose, Chadi A. Makary, Zachary M. Soler, Adam J. Kimple, Aaron N. Pearlman, Uma S. Ramaswamy, Michael Setzen, David A. Gudis
The goal of this American Rhinologic Society Expert Practice Statement (EPS) is to provide recommendations and guidance through evidence‐based consensus statements regarding pediatric septoplasty. This EPS was developed following the previously published methodology and approval process. The topics of interest included appropriate indications, safety and efficacy, timing, relevant quality of life instruments
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Multi‐institutional validation of an AI‐based sinus CT analytic platform with olfactory assessments Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-12 Conner J. Massey, Stephen M. Humphries, Jess C. Mace, Timothy L. Smith, Zachary M. Soler, Vijay R. Ramakrishnan
Key Points AI‐based CT sinus analysis may have advantages over visual based systems, for example, Lund–Mackay score. Here, we show multi‐institutional validation of an AI algorithm using novel OMC classification. Significant, robust correlations are seen between algorithm outputs and clinical outcomes.
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Chitosan‐based crosslinking for controlled topical drug release in rhinosinusitis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-11 Do‐Yeon Cho, Dong Jin Lim, Olivia J. Kelly, Daniel Skinner, Shaoyan Zhang, Martin P. Jones, Jessica Grayson, Bradford A. Woodworth
Key points Chitosan is a promising drug delivery vector for therapeutics owing to its biocompatibility. Once crosslinked with chitosan, prolonged drug release was noted regardless of hydrophilicity. Hydrophilic drugs may require different strategies to obtain a sustained release profile.
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30° anteriorly tilted CT for visualizing the drainage pathway of the frontal sinus Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-10 Tomotaka Hemmi, Kazuhiro Nomura, Mitsuru Sugawara, Ryoukichi Ikeda
Key Points The optimal tilt for anteriorly tilted coronal CT was examined. A 30° anteriorly tilted coronal CT best visualized the frontal sinus drainage pathway.
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Letter to the editor regarding “An eosinophil peroxidase activity assay predicts acute exacerbations in post‐operative chronic rhinosinusitis” Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-10 Sanjeev Yadav
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Matrix metalloproteinase‐11 regulates inverted papilloma epithelial cell migration and invasion Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-05 Kush Panara, Tan Li Hui, Deepa Keshari, Charles C. L. Tong, James N. Palmer, Nithin D. Adappa, Jennifer E. Douglas, Noam A. Cohen, Michael A. Kohanski
BackgroundInverted papilloma (IP) is a benign tumor characterized by epithelial proliferation, which has the potential for malignant transformation. However, the mechanisms driving this transformation are poorly defined. Matrix metalloproteinase‐11 (MMP‐11), a regulator of the tumor microenvironment that degrades extracellular matrix, is upregulated in IP with dysplasia. Here, we aim to investigate
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Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-05 Ethan J. Han, Christine M. Liu, Jakob L. Fischer, Jess C. Mace, Karolin Markarian, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Patricia H. Eshaghian, Yuqing A. Gao, Anne E. Getz, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Jivianne T. Lee, Douglas A. Li, Meghan Norris, Jayakar V. Nayak, Cameran Owens, Zara M. Patel, Katie Poch, Rodney J. Schlosser, Kristine A. Smith, Timothy L. Smith
BackgroundSociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.MethodsIn a prospective, multi‐institutional study, adult PwCF completed the 22‐Question SinoNasal Outcome
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The role of revision sinus surgery in the initiation of dupilumab therapy: A real‐world study of molecular and cellular features Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-03 Abigail Gaffar, Abdul Rahman Alenezi, Kathleen M. Kelly, Heather M. Kulaga, Hsin‐Tzu Keng, Amy Smith, Andrew P. Lane
Key points A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab. Revision sinus surgery immediately prior to dupilumab reduces long‐term interleukin (IL)‐4/IL‐13 tissue mRNA. Pre‐dupilumab revision surgery is associated with reduced tissue eosinophils and GATA‐3+ cells.
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Impact of elexacaftor/tezacaftor/ivacaftor CFTR modulator therapy on rates of endoscopic sinus surgery in cystic fibrosis Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-03 Graham Pingree, Mihai Bentan, Thomas Fitzpatrick, Theodore Schuman
BackgroundElexacaftor/tezacaftor/ivacaftor (ETI), a combination cystic fibrosis transmembrane receptor (CFTR) modulator, has demonstrated improved pulmonary outcomes in individuals with cystic fibrosis (CF). However, ETI's impact on functional endoscopic sinus surgery (FESS) remains unclear.MethodsThe TriNetX Analytics Research Network, consisting of 120 million global de‐identified electronic medical
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Inhalational exposure history is associated with differential sinonasal gene expression profiles and clinical outcomes in chronic rhinosinusitis patients: A pilot study Int. Forum Allergy Rhinol. (IF 7.2) Pub Date : 2024-07-03 Cameron P. Worden, Brian D. Thorp, Charles S. Ebert, Cristine N. Klatt‐Cromwell, Brent A. Senior, Adam J. Kimple, Meghan E. Rebuli, Ilona Jaspers
Key points Inhalational exposure (IE) history assessment is important and may guide chronic rhinosinusitis disease management. Combined exposure status was the most significant factor across differential gene expression analyse IE history was associated with pro‐inflammatory transcriptome changes and worse clinical outcomes.
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