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Development of a questionnaire to assess the patient perspective regarding challenges in psoriatic arthritis treatment—a mixed-methods study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-19 André Lucas Ribeiro, Júlia Andressa Tessari, Charles Lubianca Kohem, Penélope Esther Palominos, Rafael Mendonça da Silva Chakr
Limited data exist on psoriatic arthritis (PsA) treatment in lower-income regions, particularly from the patient perspective. This study explores the challenges faced by socioeconomically vulnerable PsA patients and the reasons for non-adherence to treatment guidelines. The main objective of the study is to develop a questionnaire to identify the primary challenges in PsA treatment adherence and to
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Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-16 Ivanio Alves Pereira, Nilton Salles Rosa Neto, Renan Rodrigues Neves Ribeiro do Nascimento, Eutilia Andrade Medeiros Freire, Fabricio de Souza Neves, Blanca Elena Rios Gomes Bica, Frederico Augusto Gurgel Pinheiro, Sandro Félix Perazzio, Rafael Alves Cordeiro, Henrique Ayres Mayrink Giardini, Valderilio Feijo Azevedo, Flavio Roberto Sztajnbok
Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As part of the disease, proteins that were originally soluble misfold and acquire a fibrillar conformation that renders them insoluble and resistant to proteolysis. Systemic amyloidosis is a rare, often underdiagnosed condition. In recent years, the incidence of
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Tuberculin skin test repetition after TNF-α inhibitors in patients with chronic inflammatory arthritis: a long-term retrospective cohort in endemic area Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-13 Vanessa de Oliveira Magalhães, Karina Rossi Bonfiglioli, Carina More Frade Gomes, Eloisa Bonfá, Ana Cristina de Medeiros-Ribeiro, Carla Gonçalves S. Saad, Marcelo de Medeiros Pinheiro
To evaluate the tuberculin skin test (TST) conversion in chronic inflammatory arthropathies (CIA) patients on TNFα inhibitors (TNFi) and without previous latent tuberculosis infection (LTBI) treatment. Patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) with negative LTBI were retrospectively evaluated for TST conversion and active tuberculosis (TB) after
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Anti-protein phosphatase magnesium-dependent 1A-IgM levels in patients with active ankylosing spondylitis: a potential biomarker Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-13 Yeo-Jin Lee, Eun-Ju Lee, Soo Min Ahn, Seokchan Hong, Ji Seon Oh, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
Ankylosing spondylitis (AS) has been known to have auto-inflammatory nature; hence, the efficacy of autoantibodies is low. However, studies on autoantibodies are ongoing, with some studies showing associations. Previous studies showed that anti-protein phosphatase magnesium-dependent 1A (PPM1A) IgG was increased in patients with AS and associated with radiographic progression. However, the diagnostic
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Sacroiliac and spine imaging in spondyloarthritis: Does phenotype or sex matter? Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-10 Gabriel Caetano Pereira, Natalia Pereira Machado, André Francisco Gomes, Rodrigo Luppino Assad, Fabio Henrique Carneiro, Valderílio Feijó Azevedo
Spondyloarthritis (SpA) encompasses a spectrum of immune-mediated inflammatory conditions primarily affecting the axial skeleton, including sacroiliitis and spondylitis, each with distinct features. This study aimed to investigate imaging disparities, focusing on sacroiliac magnetic resonance and spine radiography, across phenotypes and between males and females in axial SpA. A cross-sectional study
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Progranulin mediates the onset of pristane induced systemic lupus erythematosus Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-09 Michun He, Aubryanna Hettinghouse, Yufei Bi, Yuehong Chen, Chuanju Liu
Progranulin (PGRN) is a growth factor-like molecule with diverse roles in homeostatic and pathogenic processes including the control of immune and inflammatory responses. Pathogenic inflammation is a hallmark of systemic lupus erythematosus (SLE) and elevated serum levels of PGRN has been evaluated as a biomarker of disease activity in SLE. However, the role of PGRN in SLE has not been fully investigated
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Effect of fatigue on quality of life in patients with rheumatoid arthritis: the chain mediating role of resilience and self-efficacy Adv. Rheumatol. (IF 2.0) Pub Date : 2024-09-09 Jian Zhou, Xinxin Fan, Yuqin Gan, Zongting Luo, Hong Qi, Yuqiong Cao
Exploring the effect of resilience and self-efficacy in mediating the chain between fatigue and quality of life(QOL) in patients with rheumatoid arthritis (RA). From June 2022 to November 2022, 423 RA patients were chosen by a convenience sample method from two tertiary care facilities in Chengdu, Sichuan Province. General Information Questionnaire, Bristol Multidimensional Scale of Fatigue in Patients
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Determining the accuracy of the leukocyte esterase reagent strip test in the rapid diagnosis of adult septic arthritis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-30 Peyman Mirghaderi, Mohammad-Taha Pahlevan-Fallahy, Jamil Mahmoudi, S.M. Javad Mortazavi
Septic arthritis is a dangerous disease that occurs when microorganisms enter synovial fluid. It needs fast and accurate management; otherwise, it can harm the patient’s life. Currently, the tests measure WBC and PMN in SF, so we hypothesized to use a proxy that is easier and faster to measure. Leukocyte esterase is an enzyme secreted by neutrophils that can be found in the synovial fluid of SA patients
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The influence of environmental factors related to Juvenile Dermatomyositis (JDM), its course and refractoriness to treatment Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-30 Clarissa C.M. Valões, Tamima M. Arabi, Alfésio L.F. Braga, Lúcia M.A. Campos, Nádia E. Aikawa, Kátia T. Kozu, Clovis A. Silva, Sylvia C.L. Farhat, Adriana M. Elias
To evaluate the influence of environmental factors and prematurity relating to juvenile dermatomyositis (JDM), its course and refractoriness to treatment. A case-control study with 35 patients followed up at a tertiary hospital and 124 healthy controls, all residents of São Paulo. Patients were classified according to monocyclic, polycyclic or chronic disease courses and refractoriness to treatment
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Challenges in implementing treat-to-target in rheumatoid arthritis: a perspective from Brazilian rheumatologists Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-26 Adriana Maria Kakehasi, Angela Luzia Branco Pinto Duarte, Claiton Viegas Brenol, Diogo Souza Domiciano, Ieda Maria Magalhães Laurindo, Karina Rossi Bonfiglioli, Licia Maria Henrique da Mota, Maya H. Buch, Eduardo de Almeida Macêdo, Ricardo Machado Xavier
Patient management in rheumatoid arthritis (RA) has evolved to a “treat-to-target” (T2T) approach, which entails intensive treatment and regular follow-up with the goal of achieving low levels of disease activity or clinical remission. Even though a T2T approach is endorsed by professional organizations and yields superior outcomes, its implementation remains incomplete. EVEREST (EleVatE care in RhEumatoid
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Inflammatory turmoil within: an exploration of autoinflammatory disease genetic underpinnings, clinical presentations, and therapeutic approaches Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-22 Kátia Tomie Kozu, Renan Rodrigues Neves Ribeiro do Nascimento, Patrícia Pontes Aires, Rafael Alves Cordeiro, Thais Costa Lima de Moura, Flavio Roberto Sztajnbok, Ivanio Alves Pereira, Adriana Almeida de Jesus, Sandro Félix Perazzio
Systemic autoinflammatory diseases (SAIDs) arise from dysregulated innate immune system activity, which leads to systemic inflammation. These disorders, encompassing a diverse array of genetic defects classified as inborn errors of immunity, are significant diagnostic challenges due to their genetic heterogeneity and varied clinical presentations. Although recent advances in genetic sequencing have
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Targeting Bruton’s tyrosine kinase (BTK) as a signaling pathway in immune-mediated diseases: from molecular mechanisms to leading treatments Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-21 Gita Manzari Tavakoli, Niloufar Yazdanpanah, Nima Rezaei
Bruton’s tyrosine kinase (BTK), a nonreceptor tyrosine kinase, plays a remarkable role in the transmission and amplification of extracellular signals to intracellular signaling pathways. Various types of cells use the BTK pathway to communicate, including hematopoietic cells particularly B cells and T cells. The BTK pathway plays a role in controlling the proliferation, survival, and functions of B
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Brazilian version of the “Primary Sjögren’s Syndrome - Quality of Life questionnaire (PSS-QoL)”: translation, cross-cultural adaptation and validation Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-19 Samira Tatiyama Miyamoto, Érica Vieira Serrano, Ana Paula Espíndula Gianórdoli, Lara Betini Altoé, Bianca Domingos Noronha, Pedro Henrique Alves dos Santos, Ana Paula Truhlar Pedrini, Nicole Reis Souza da Silva, Letícia Fonseca Favarato, Luíza Vallory Alochio, Weider Andrade Tomé, Angelika Lackner, Valéria Valim
The Primary Sjögren’s Syndrome Quality of Life questionnaire (PSS-QoL) is the first specific instrument to assess health-related quality of life (HRQoL) in Sjögren’s disease (SjD). The aim is to translate and cross-culturally adapt the PSS-QoL into Brazilian Portuguese and to evaluate its psychometric properties. The original English version was translated into Brazilian Portuguese by two native Brazilians
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Principles of clinical genetics for rheumatologists: clinical indications and interpretation of broad-based genetic testing Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-14 Renan Rodrigues Neves Ribeiro do Nascimento, Caio Robledo D’Angioli Costa Quaio, Christine Hsiaoyun Chung, Dewton de Moraes Vasconcelos, Flavio Roberto Sztajnbok, Nilton Salles Rosa Neto, Sandro Félix Perazzio
Advances in DNA sequencing technologies, especially next-generation sequencing (NGS), which is the basis for whole-exome sequencing (WES) and whole-genome sequencing (WGS), have profoundly transformed immune-mediated rheumatic disease diagnosis. Recently, substantial cost reductions have facilitated access to these diagnostic tools, expanded the capacity of molecular diagnostics and enabled the pursuit
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Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-12 Vitor Alves Cruz, Camila Guimarães, Jozelia Rêgo, Ketty Lysie Libardi Lira Machado, Samira Tatiyama Miyamoto, Ana Paula Neves Burian, Laiza Hombre Dias, Flavia Zon Pretti, Danielle Cristina Filgueira Alves Batista, José Geraldo Mill, Yasmin Gurtler Pinheiro de Oliveira, Carolina Strauss Estevez Gadelha, Maria da Penha Gomes Gouveia, Anna Carolina Simões Moulin, Bárbara Oliveira Souza, Laura Gonçalves
Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. To
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Sarcoidosis: a general overview Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-12 Fabricio Souza Neves, Ivanio Alves Pereira, Flavio Sztajnbok, Nilton Salles Rosa Neto
Sarcoidosis is a systemic inflammatory disease of unknown origin, which consists of the formation of multiple sterile noncaseating granulomas. Inhaled antigens are believed to initiate disease in prone individuals, considering that almost all patients present pulmonary or mediastinal lymph node disease. Extrapulmonary manifestations are common and diverse: practically any organ system can be affected
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Exploring the association of serum prolactin with serum glucose levels and clinical findings in a cohort of patients with early rheumatoid arthritis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-07 Lidiana Bandeira de Santana, Thomas Alves de Souza Lima, Amanda Rodrigues Costa, Leticia Assad Maia Sandoval, Talita Yokoy de Souza, Licia Maria Henrique da Mota, Luciana Ansaneli Naves
In the context of rheumatoid arthritis and its systemic inflammatory implications, there is an increasing interest in investigating the role of prolactin in the clinical and metabolic aspects of the disease. This study aimed to explore the potential links between serum prolactin levels, serum glucose levels, and the clinical manifestations of arthritis. This exploratory, cross-sectional, observational
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Characteristics of patients with difficult-to-treat rheumatoid arthritis: a descriptive retrospective cohort study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-08-06 Wen Qi, Antoine Robert, Narcisse Singbo, Lucie Ratelle, Paul R. Fortin, Louis Bessette, Jacques P. Brown, Laëtitia Michou
In 2021, an EULAR task force published a definition of difficult-to-treat rheumatoid arthritis (D2T RA). Our current knowledge of D2T RA with the EULAR definition is based on European and Asian cohorts, and no North American cohort has yet to be published. The aim of this study was to compare D2T RA patients to non-D2T RA who are good responders to advanced therapy, and to describe their evolution
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Ketamine in fibromyalgia: a systematic review Adv. Rheumatol. (IF 2.0) Pub Date : 2024-07-29 Jozélio Freire de Carvalho, Eduardo Pondé de Sena
Fibromyalgia (FM) subjects are treated with antidepressant agents; in most cases, these drugs lose efficacy or have adverse effects. Ketamine is an anesthetic drug used in FM in some studies. This article aims to systematically review the safety and efficacy of ketamine in fibromyalgia (FM) patients. We systematically searched articles on FM and ketamine published at Pubmed from 1966 to 2021. This
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Misconceptions about trigger finger: a scoping review. Definition, pathophysiology, site of lesion, etiology. Trigger finger solving a maze Adv. Rheumatol. (IF 2.0) Pub Date : 2024-07-11 Eslam Shohda, Reda Ali Sheta
Trigger finger (TF) is a disorder characterized by snapping or locking a finger. It has a prevalence of greater than 3% in the general population; however, this estimate could be increased to 5% up to 20% in diabetic patients. Some unreal ambiguity about definition, pathophysiology, site of lesion, and etiology are found among researchers and clinicians, leading to a lack of understanding of all aspects
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2023 Brazilian Society of Rheumatology guidelines for the treatment of systemic sclerosis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-07-10 Cristiane Kayser, Sandra Maximiano de Oliveira Delgado, Adriana Fontes Zimmermann, Alex Magno Coelho Horimoto, Ana Paula Toledo Del Rio, Carolina de Souza Müller, Cintia Zumstein Camargo, Cristiano Michelini Lupo, Daniela Aparecida de Moraes, Eduardo José Do Rosário E Souza, Flávia Patrícia Sena Teixeira Santos, Juliana Yuri Sekiyama, Lilian Scussel Lonzetti, Lucas Victória de Oliveira Martins, Mailze
Systemic sclerosis (SSc) is a rare chronic autoimmune disease with heterogeneous manifestations. In the last decade, several clinical trials have been conducted to evaluate new treatment options for SSc. The purpose of this work is to update the recommendations of the Brazilian Society of Rheumatology in light of the new evidence available for the pharmacological management of SSc. A systematic review
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Recommendations on cutaneous and hematological manifestations of Sjögren’s disease by the Brazilian Society of Rheumatology Adv. Rheumatol. (IF 2.0) Pub Date : 2024-07-09 Alisson Pugliesi, Danielle Christinne Soares do Egypto, Guilherme Duffles, Diego Ustárroz Cantali, Sandra Gofinet Pasoto, Fabiola Reis Oliveira, Valeria Valim, Maria Lucia Lemos Lopes, Samira Tatiyama Miyamoto, Marilena Leal Mesquita Silvestre Fernandes, Sonia Cristina de Magalhães Souza Fialho, Aysa César Pinheiro, Laura Caldas dos Santos, Simone Appenzeller, Sandra Lucia Euzébio Ribeiro, Tatiana
Sjogren’s disease (SjD) is an autoimmune disease that is characterized not only by the sicca symptoms it causes but also by its systemic nature, which is capable of several and not yet fully understood extraglandular manifestations. To gain a clearer understanding of these manifestations as well as a better practical approach, a panel of experts from the Brazilian Society of Rheumatology conducted
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Nirmatrelvir plus ritonavir in patients with underlying rheumatological diseases, in preventing COVID-19 related hospitalization and death Adv. Rheumatol. (IF 2.0) Pub Date : 2024-07-03 Faiza Javed, Anthony A. Mangino, Paramarajan Piranavan
The benefits of antiviral therapy in the COVID-19 patient population with underlying rheumatic disease with or without immunosuppression are not entirely clear. The percentage of such patients in a recently published studies (Oral Nirmatrelvir for High-Risk, non-hospitalized Adults with COVID-19) was < 5% [1, 2]. Our study aims to determine the utility of Nirmatrelvir plus ritonavir in patients with
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Referrals for rheumatologic evaluation following a positive antinuclear antibody test result. A cross-sectional single center Brazilian study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-06-30 Leonardo Borgato Della Vecchia, Caio Delano Campos Oliveira Assis, Fernando de Oliveira Salatiel, Maria Thereza Santos Cirino, Maria Eduarda Vogel Scarpante, Vanessa Monteiro Oliveira, Letícia Pedroso Meneghin, Maria Júlia Gonçalves Silva, Victória Ferini dos Santos, Natália Pavoni Catardo, Isabela Pulini Nemesio, Lívia Loamí Ruyz Jorge de Paula, Carolina Borges Garcia Sasdelli, Ana Beatriz Santos
In general, patients are referred for rheumatological evaluation due to isolated laboratory abnormalities, especially antinuclear antibody (ANA) positivity, with the risk of more severe patients remaining on the waiting list for longer than desired. The aim of this study was to analyze the demographic, clinical, and laboratory information of patients referred to a specialized rheumatological care unit
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II Brazilian Society of Rheumatology consensus for lupus nephritis diagnosis and treatment Adv. Rheumatol. (IF 2.0) Pub Date : 2024-06-18 Edgard Torres dos Reis-Neto, Luciana Parente Costa Seguro, Emília Inoue Sato, Eduardo Ferreira Borba, Evandro Mendes Klumb, Lilian Tereza Lavras Costallat, Marta Maria das Chagas Medeiros, Eloisa Bonfá, Nafice Costa Araújo, Simone Appenzeller, Ana Carolina de Oliveira e Silva Montandon, Emily Figueiredo Neves Yuki, Roberto Cordeiro de Andrade Teixeira, Rosa Weiss Telles, Danielle Christinne Soares
To develop the second evidence-based Brazilian Society of Rheumatology consensus for diagnosis and treatment of lupus nephritis (LN). Two methodologists and 20 rheumatologists from Lupus Comittee of Brazilian Society of Rheumatology participate in the development of this guideline. Fourteen PICO questions were defined and a systematic review was performed. Eligible randomized controlled trials were
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Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial—the DIETA trial Adv. Rheumatol. (IF 2.0) Pub Date : 2024-06-13 Daniele Scherer, Beatriz Figueiredo Leite, Melissa Aparecida Morimoto, Thauana Luiza Oliveira, Barbara N. Carvalho Klemz, Rosana A. M. Soares Freitas, Caroline Pappiani, Nágila R. Teixeira Damasceno, Marcelo de Medeiros Pinheiro
Patients with psoriatic arthritis have some lipid metabolism changes and higher risk of metabolic syndrome (MetS) and cardiovascular diseases, regardless of traditional risk factors, suggesting that chronic inflammation itself plays a central role concerning the atherosclerosis. However, there is a lack of information regarding atherogenic pattern and lipoprotein subfractions burden in these individuals
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TAK-242 (Resatorvid) inhibits proinflammatory cytokine production through the inhibition of NF-κB signaling pathway in fibroblast-like synoviocytes in osteoarthritis patients Adv. Rheumatol. (IF 2.0) Pub Date : 2024-06-07 Mohammadreza Khomeijani-Farahani, Jafar karami, Elham Farhadi, Samaneh Soltani, Ali-Akbar Delbandi, Mehdi Shekarabi, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Mahdi Mahmoudi, Masoomeh Akhlaghi
Fibroblast-like synoviocytes (FLSs) are involved in osteoarthritis (OA) pathogenesis through pro-inflammatory cytokine production. TAK-242, a TLR4 blocker, has been found to have a significant impact on the gene expression profile of pro-inflammatory cytokines such as IL1-β, IL-6, TNF-α, and TLR4, as well as the phosphorylation of Ikβα, a regulator of the NF-κB signaling pathway, in OA-FLSs. This study
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Hypocitraturia as a biomarker of renal tubular acidosis in patients with Sjögren’s disease Adv. Rheumatol. (IF 2.0) Pub Date : 2024-06-03 Rafael Coradin, Maria Lúcia Lemos Lopes, João Carlos Goldani, Pedro Enrico Ventura, Elizete Keitel
Sjögren’s disease (SD) is an immune-mediated chronic inflammatory disease that affects epithelial tissues, mainly salivary and lacrimal glands. It also presents extraglandular manifestations. The main renal manifestation is tubulointerstitial nephritis (TIN), which can manifest as renal tubular acidosis (RTA). Urinary citrate may be a biomarker of RTA in these patients. The objective of this study
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High fat diet increases the severity of collagen-induced arthritis in mice by altering the gut microbial community Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-30 Yang Zhang, Jie Zhang, Yantong Liu, Shuang Ren, Ning Tao, Fanyan Meng, Qi Cao, Ruoshi Liu
Research has demonstrated that obesity may be associated with rheumatoid arthritis (RA). In addition, gut microbiota and its metabolites contribute to the occurrence and development of RA and obesity. However, the mechanism by which obesity affects RA remains unclear. In this study, we aimed to investigate whether gut microbiota and their metabolites alter the effects of high fat diet (HFD) on the
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Serum osteoprotegerin and its gene polymorphisms in patients with Takayasu’s arteritis: a bicentric cross-sectional study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-28 Camila da Silva Cendon Duran, Valéria de Falco Caparbo, Mittermayer Barreto Santiago, Bidossessi Wilfried Hounkpe, Ana Luisa Souza Pedreira, Isabella Vargas de Souza Lima, Henrique Ayres Mayrink Giardini, Virgínia Lucia Nazario Bonoldi, Diogo Souza Domiciano, Samuel Katsuyuki Shinjo, Rosa Maria R Pereira
Takayasu’s arteritis (TAK) patients are at an elevated risk of metabolic syndrome and cardiovascular diseases (CVD). Currently, there are no well-validated biomarkers to assess this risk in this population. Previous research in different cohorts has linked serum levels of osteoprotegerin (OPG) and its polymorphisms to accelerated atherosclerosis and a marker of poor prognosis in CVD. Thus, we assessed
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Comparative study of two laboratory techniques for the detection of HLA-B27 in patients with axial spondyloarthritis: a cross-sectional analysis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-23 Ricardo dos Santos Angeli, André Lucas Ribeiro, Charles Lubianca Kohem, Ricardo Machado Xavier, Odirlei André Monticielo
The diagnostic and prognostic relevance of Human Leukocyte Antigen B-27 (HLA-B27) in Axial Spondyloarthritis (AxSpA) is undeniable, with 70% of Ankylosing Spondylitis (AS) patients carrying the B27 gene, contrasted with a mere 4.35% in the general population. Flow cytometry (FC) and Polymerase Chain Reaction (PCR) have emerged as the predominant techniques for routine HLA-B27 typing. While various
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Position statement of the Brazilian society of Rheumatology on mesna use as a preventive therapy for bladder disease in patients with systemic autoimmune diseases and systemic vasculitis under cyclophosphamide treatment Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-21 Alexandre Wagner S. de Souza, João Gabriel Dantas, Ana Carolina de Oliveira e Silva Montandon, Ana Luísa Calich, Andrea Rocha de Saboia Mont’ Alverne, Andrese Aline Gasparin, Dante Bianchi, Emily Figueiredo Neves Yuki, Nathalia Sacilotto, Edgard Torres dos Reis Neto, Odirlei André Monticielo, Ivanio Alves Pereira
To review current literature to support the use of mesna as a preventive therapy for hemorrhagic cystitis and bladder cancer in patients with systemic autoimmune diseases and systemic vasculitis treated with cyclophosphamide. The search for articles was conducted systematically through MEDLINE, LILACS, Cochrane Library, and Embase databases. Only articles in English were selected. For available records
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Cross-sectional study of psychiatric disorders in patients with chronic musculoskeletal pain and individuals without pain Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-10 Ruben Horst Duque, Carla Vasconcelos Cáspar Andrade, Valdir Ribeiro Campos, Isac Ribeiro Moulaz, Laíssa Fiorotti Albertino, Maria Bernadete Renoldi de Oliveira Gavi
Musculoskeletal chronic pain is a leading cause of global disability and laboral incapacity. However, there is a lack of population-based studies that investigate the relationship between chronic pain and mental disorders with a control group, particularly among low- and middle-income countries. Chronic pain is a serious public health problem in terms of human suffering, and in terms of socioeconomic
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Presentation of enthesitis-related arthritis and juvenile-onset spondyloarthritis: a cross-sectional study in a pediatric and adult clinic Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-08 Sean Hideo Shirata Lanças, Matheus Zanata Brufatto Furlan, Taciana de Albuquerque Pedrosa Fernandes, Sula Glaucia Lage Drumond, Claudia Saad Magalhães
Juvenile idiopathic arthritis (JIA) comprises a whole spectrum of chronic arthritis starting before 16 years of age. The study aims to explore the clinical and demographic descriptors, treatment, and disease progression of enthesitis-related arthritis (ERA) in comparison with juvenile-onset spondyloarthritis (SpA). Cross-sectional analysis of consecutive patients in two dedicated clinics, with a single
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Association of systemic lupus erythematosus standard of care immunosuppressants with glucocorticoid use and disease outcomes: a multicentre cohort study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-08 Ricardo Azêdo de Luca Montes, Molla Huq, Timothy Godfrey, Shereen Oon, Alicia Calderone, Rangi Kandane-Rathnayake, Worawit Louthrenoo, Shue-Fen Luo, Yeong-Jian Jan Wu, Vera Golder, Aisha Lateef, Sandra V. Navarra, Leonid Zamora, Laniyati Hamijoyo, Sargunan Sockalingam, Yuan An, Zhanguo Li, Yasuhiro Katsumata, Masayoshi Harigai, Madelynn Chan, Fiona Goldblatt, Sean O’Neill, Chak Sing Lau, Jiacai Cho
This study examines the association of standard-of-care systemic lupus erythematosus (SLE) medications with key outcomes such as low disease activity attainment, flares, damage accrual, and steroid-sparing, for which there is current paucity of data. The Asia Pacific Lupus Collaboration (APLC) prospectively collects data across numerous sites regarding demographic and disease characteristics, medication
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Hyperuricemia and intravenous fat emulsion are risk factors for gout flares during active gastrointestinal bleeding: a case control study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-03 Yujie Jiang, Xuelian Hong, Bingtian Xia, Hongwei Du
It is well-established that patients with a history of gout are more susceptible to experiencing gastrointestinal bleeding. Gout flare during active gastrointestinal bleeding poses a significant challenge due to the gastrointestinal side effects of anti-inflammatory therapy. This study sought to investigate the risk factors associated with gout flares during episodes of gastrointestinal bleeding. We
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Subclinical joint inflammation in rheumatoid arthritis: comparing thermal and ultrasound imaging at the metacarpophalangeal joint Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-03 York Kiat Tan, Gek Hsiang Lim
While ultrasound and MRI are both superior to clinical examination in the detection of joint inflammation, there is presently a lack of data whether thermography may be similarly useful in the assessment of joint inflammation in patients with RA. Our study aims to evaluate the use of thermography in detecting subclinical joint inflammation at clinically quiescent (non-tender and non-swollen) metacarpophalangeal
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IgG4-related disease—rare but you should not forget it Adv. Rheumatol. (IF 2.0) Pub Date : 2024-05-03 Frederico Augusto Gurgel Pinheiro, Ivanio Alves Pereira, Alexandre Wagner Silva de Souza, Henrique Ayres Mayrink Giardini, Rafael Alves Cordeiro
Immunoglobulin G4-related disease is a systemic immune-mediated disease with insidious evolution characterized by fibroinflammatory lesions over virtually any organ system. Despite the remarkable progression of knowledge, its etiology remains undefined. Due to its relapse-remitting pattern, it could accumulate irreversible damage, increasing comorbidities and mortality. This paper emphasizes key concepts
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Effectiveness of secukinumab in patients with psoriasis and psoriatic arthritis in a Saudi real-world setting Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-29 Ibrahim A. Al-Homood, Mohammed Alajlan, Majid Alberdisi, Mohammad Alturki, Ahmed Ali Ahmed, Nancy Zakaria
Psoriasis (PsO) is an immune-mediated chronic inflammatory disease that results in severe outcomes that impact the patient’s quality of life and work productivity. We investigated the effectiveness of secukinumab in patients with chronic plaque psoriasis and psoriatic arthritis (PsA) over a 12-month period. This was a longitudinal, retrospective study of the medical records of 81 patients with psoriasis
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To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-26 Gustavo Gomes Resende, Carla Goncalves Schahin Saad, Claudia Diniz Lopes Marques, Sandra Lúcia Euzébio Ribeiro, Maria Bernadete Renoldi de Oliveira Gavi, Michel Alexandre Yazbek, Adriana de Oliveira Marinho, Rita de Cássia Menin, Manuella Lima Gomes Ochtrop, Andressa Miozzo Soares, Nara Gualberto Cavalcanti, Jamille Nascimento Carneiro, Glaucio Ricardo Werner de Castro, José Mauro Carneiro Fernandes
There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27
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Unraveling the genetic collagen connection: clinical and therapeutic insights on genetic connective tissue disorders Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-25 Nilton Salles Rosa Neto, Ivânio Alves Pereira, Flávio Roberto Sztajnbok, Valderílio Feijó Azevedo
Hereditary connective tissue disorders include more than 200 conditions affecting different organs and tissues, compromising the biological role of the extracellular matrix through interference in the synthesis, development, or secretion of collagen and/or its associated proteins. The clinical phenotype includes multiple signs and symptoms, usually nonspecific but of interest to rheumatologists because
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Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-22 Thomas J. Schnitzer, Philip G. Conaghan, Francis Berenbaum, Lucy Abraham, Joseph C. Cappelleri, Andrew G. Bushmakin, Lars Viktrup, Ruoyong Yang, Mark T. Brown
To illustrate how (standardised) effect sizes (ES) vary based on calculation method and to provide considerations for improved reporting. Data from three trials of tanezumab in subjects with osteoarthritis were analyzed. ES of tanezumab versus comparator for WOMAC Pain (outcome) was defined as least squares difference between means (mixed model for repeated measures analysis) divided by a pooled standard
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Characterization of the patterns of care, access, and direct cost of systemic lupus erythematosus in Brazil: findings from the Macunaíma study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-19 Mirhelen Mendes de Abreu, Odirlei Andre Monticielo, Vander Fernandes, Dalianna Luise Andrade Souto Rodrigues, Cristhiane Almeida Leite da Silva, Alexandre Cristovão Maiorano, Fernando dos Santos Beserra, Flavia Rachel Moreira Lamarão, Bruna Medeiros Gonçalves de Veras, Nathalie David, Magda Araújo, Marcelly Cristinny Ribeiro Alves, Matheus Amaral Stocco, Fernando Mello Lima, Emilly Borret, Andrese
A cost of illness (COI) study aims to evaluate the socioeconomic burden that an illness imposes on society as a whole. This study aimed to describe the resources used, patterns of care, direct cost, and loss of productivity due to systemic lupus erythematosus (SLE) in Brazil. This 12-month, cross-sectional, COI study of patients with SLE (ACR 1997 Classification Criteria) collected data using patient
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Unveiling the clinical spectrum of relapsing polychondritis: insights into its pathogenesis, novel monogenic causes, and therapeutic strategies Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-16 Blanca E R G Bica, Alexandre Wagner S de Souza, Ivânio Alves Pereira
Relapsing polychondritis is a rare multisystem disease involving cartilaginous and proteoglycan-rich structures. The diagnosis of this disease is mainly suggested by the presence of flares of inflammation of the cartilage, particularly in the ears, nose or respiratory tract, and more rarely, in the presence of other manifestations. The spectrum of clinical presentations may vary from intermittent episodes
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Hemophagocytic lymphohistiocytosis and macrophage activation syndrome: two rare sides of the same devastating coin Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-16 Flavio Sztajnbok, Adriana Rodrigues Fonseca, Leonardo Rodrigues Campos, Kátia Lino, Marta Cristine Félix Rodrigues, Rodrigo Moulin Silva, Rozana Gasparello de Almeida, Sandro Félix Perazzio, Margarida de Fátima Fernandes Carvalho
Hemophagocytic lymphohistiocytosis (HLH) is a rare genetic hyperinflammatory syndrome that occurs early in life. Macrophage activation syndrome (MAS) usually refers to a secondary form of HLH associated with autoimmunity, although there are other causes of secondary HLH, such as infections and malignancy. In this article, we reviewed the concepts, epidemiology, clinical and laboratory features, diagnosis
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Prevalence of spondyloarthritis in inflammatory bowel disease according ASAS and ultrassonography and its correlation with plasma calprotectin Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-15 Míriam Küster Huber, Valeria Valim, Érica Vieira Serrano, José Alexandre Mendonça, Rafael Burgomeister Lourenço, Thaisa Moraes Ribeiro Espírito Santo, Hilde Nordal, Maria de Fátima Bissoli, Maria Bernadete Renoldi de Oliveira Gavi
Enteropathic spondyloarthritis is underdiagnosed and inflammatory biomarkers and ultrasonography (US) could be useful for screening inflammatory bowel disease (IBD) patients. The objective of this study was to evaluate the prevalence of spondyloarthritis (SpA) in IBD patients, according to the Assessment of SpondyloArthritis International Society (ASAS) criteria and the correlation of results of US
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Drug survival and change of disease activity using a second janus kinase inhibitor in patients with difficult-to-treat rheumatoid arthritis who failed to a janus kinase inhibitor and subsequent biologics Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-15 Oh Chan Kwon, Wonho Choi, Soo Min Ahn, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Min-Chan Park, Yong-Gil Kim
To assess the drug survival and change of disease activity using a second Janus kinase inhibitor (JAKi) after failure to a JAKi and subsequent biologic disease-modifying anti-rheumatic drugs (bDMARDs) in patients with difficult-to-treat rheumatoid arthritis (RA). This retrospective cohort study included 32 patients with difficult-to-treat RA who failed to a JAKi and subsequently to one or more bDMARDs
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Ultrasonographic and power doppler parameters of nails fail to differentiate between onychodystrophy in patients with psoriasis vulgaris or psoriatic arthritis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-04-11 Anber Ancel Tanaka, Betina Werner, Annelise Correa Bueno Bragatto, Thelma Larocca Skare, Bárbara Stadler
Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy. A cross-sectional study
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Effects of intra-articular injection of platelet-rich plasma on the inflammatory process and histopathological characteristics of cartilage and synovium in animals with osteoarthritis: a systematic review with meta-analysis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-29 Homero Garcia-Motta, Cristiano Carvalho, Evelyn Maria Guilherme, Marcos Paulo Braz de Oliveira, Karina Nogueira Zambone Pinto Rossi
Osteoarthritis (OA) affects the entire joint, causing structural changes in articular cartilage, subchondral bone, ligaments, capsule, synovial membrane, and periarticular muscles that afflicts millions of people globally, leading to persistent pain and diminished quality of life. The intra-articular use of platelet-rich plasma (PRP) is gaining recognition as a secure therapeutic approach due to its
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Predictors of serious infections in rheumatoid arthritis—a prospective Brazilian cohort Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-29 Ana Luisa Bagno de Almeida, Maria Fernanda B. Resende Guimarães, Maria Raquel da Costa Pinto, Leticia Rocha Pereira, Ana Paula Monteiro Gomides Reis, Karina Rossi Bonfiglioli, Paulo Louzada-Junior, Rina Dalva Neubarth Giorgi, Gláucio Ricardo Werner de Castro, Sebastião Cezar Radominski, Claiton Viegas Brenol, Alisson Pugliesi, Licia Maria Henrique da Mota, Geraldo da Rocha Castelar-pinheiro
Infections increase mortality and morbidity and often limit immunosuppressive treatment in rheumatoid arthritis patients. To analyze the occurrence of serious infections and the associated factors in a cohort of rheumatoid arthritis patients under real-life conditions. We analyzed data from the REAL, a prospective observational study, that evaluated Brazilian RA patients, with clinical and laboratory
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What should rheumatologists know about Gaucher disease and Fabry disease? Connecting the dots for an overview Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-22 Rafael Alves Cordeiro, Nilton Salles Rosa Neto, Henrique Ayres Mayrink Giardini
Gaucher and Fabry diseases are lysosomal storage disorders in which deficient enzyme activity leads to pathological accumulation of sphingolipids. These diseases have a broad phenotypic presentation. Musculoskeletal symptoms and pain complaints are frequently reported by patients. Thus, rheumatologists can be contacted by these patients, contributing to the correct diagnosis, earlier indication of
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Effectiveness and safety of biological and target synthetic drugs treatment for psoriatic arthritis: a systematic review with network meta-analysis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-21 Thais Montezuma, Livia Fernandes Probst, Matheus Oliveira Almeida
Psoriatic arthritis (PA) is a chronic inflammatory systemic arthritis that can result in loss of functional capacity and joint deformation. This systematic review assessed the effectiveness and safety of biological and target synthetic drugs for treating PA. We searched for randomized clinical trials (RCTs) that evaluated the use of Adalimumab, Etanercept, Infliximab, Golimumab, Secukinumab, Certolizumab
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Clinical course of nontuberculous mycobacterial pulmonary disease in patients with rheumatoid arthritis Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-15 Nakwon Kwak, Jinyoung Moon, Joong-Yub Kim, Jun Won Park, Jae-Joon Yim
The impact of rheumatoid arthritis (RA) on nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been well established. In this study, we investigated the clinical course of NTM-PD in patients with RA and the impact of RA on the prognosis of NTM-PD. We analyzed patients who developed NTM-PD after being diagnosed with RA from January 2004 to August 2023 at a tertiary referral hospital in South
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Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-06 Yu-jing Zhang, Li-feng Chen, Xu Li, Jian-hua Chen, Zhang-kui Tan
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which might trigger cartilage, bone damage, and disability. Recent studies have suggested that Tetramethylpyrazine (TMP), an alkaloid monomer isolated from the rhizome of the traditional herbal medicine Ligusticum wallichii Franch, exerts a broad spectrum of pharmacological properties, containing anti-inflammatory. This study aimed
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Clinical characteristics and risk factors associated with bone erosion in patients with tophi Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-04 Zhuyi Ji, Yukai Huang, Ling Liang, Paifeng Lin, Xin Guo, Qidang Huang, Zhengping Huang, Shuyang Chen, Zhixiang Huang, Biao Wang, Lixin Huang, Shanmiao Sun, Weiming Deng, Tianwang Li
If a large amount of urate crystals is deposited in a joint cavity for an extended period of time, bone erosion will occur and gradually cause skeletal muscle necrosis and joint deformity. The aim of this study was to describe the clinical characteristics and factors associated with bone erosion in gout patients with tophi. A total of 210 gout patients with tophi were enrolled and divided into a bone
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Elevated expression of Toll-like receptor 7 and its correlation with clinical features in patients with primary Sjögren’s syndrome Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-04 Huimin Yang, Chao Sun, Xin Wang, Tao Wang, Changhao Xie, Zhijun Li
The labial salivary glands (LSGs) are important for the diagnosis, evaluation of therapeutic efficacy, and genetic analyses of primary Sjögren’s syndrome (pSS). In autoimmune diseases, the recognition of self nucleic acids and viral RNA and DNA through endogenous Toll-like receptor(TLR) triggers the production of type I IFN and pro-inflammatory cytokines, leading to the occurrence and progression of
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Lyme disease and Whipple’s disease: a comprehensive review for the rheumatologist Adv. Rheumatol. (IF 2.0) Pub Date : 2024-03-04 Henrique Ayres Mayrink Giardini, Fabricio Souza Neves, Ivanio Alves Pereira, Rafael Alves Cordeiro
Despite their rarity, Lyme disease and Whipple’s disease are of significant importance in rheumatology, as both can manifest as chronic arthritis, presenting challenges in the differential diagnosis of inflammatory arthropathies. In Lyme disease, arthritis typically emerges as a late manifestation, usually occurring six months after the onset of erythema migrans. The predominant presentation involves
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Eye signs as a novel risk predictor in pulmonary arterial hypertension associated with systemic lupus erythematosus Adv. Rheumatol. (IF 2.0) Pub Date : 2024-02-29 Jianbin Li, Jiangbiao Xiong, Pengcheng Liu, Yilin Peng, Shuang Cai, Xia Fang, Shujiao Yu, Jun Zhao, Rui Wu
To investigate the role of eye signs in predicting poor outcomes in systemic lupus erythematosus (SLE) patients with pulmonary arterial hypertension (PAH). This prospective observational study recruited patients diagnosed with SLE-PAH from Jan. 2021 to Dec. 2021 at the First Affiliated Hospital of Nanchang University; those with other potential causes of PAH were excluded. The evaluation of various
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Inflammatory cytokines and their potential role in Sjogren’s syndrome risk: insights from a mendelian randomization study Adv. Rheumatol. (IF 2.0) Pub Date : 2024-02-16 Wenbin Shi, Yuli Xu, Anan Zhang, Xiqun Jia, Shuhua Liu, Ziyang Hu
This study aimed to investigate the causal impact of inflammatory cytokines on Sjogren’s Syndrome (SS) and to identify potential biomarkers for SS clinical management using Mendelian Randomization (MR). Leveraging GWAS summary data of inflammatory cytokines and SS, we executed the first two-sample MR analysis. Genetic variants from prior GWASs associated with circulating inflammatory cytokines served
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Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review Adv. Rheumatol. (IF 2.0) Pub Date : 2024-02-06 Matheus Zanata Brufatto, Sean Hideo Shirata Lanças, Taciana de Albuquerque Pedrosa Fernandes, Adriana Maluf Elias Sallum, Lucia Maria Arruda Campos, Ana Paula Sakamoto, Maria Teresa Terreri, Flavio Roberto Sztajnbok, Blanca Elena Rios Gomes Bica, Virginia Paes Leme Ferriani, Luciana Martins de Carvalho, Clovis Artur Almeida Silva, Claudia Saad-Magalhaes
Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis. A retrospective case-notes review, in a nationwide