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Mendelian randomization study of childhood asthma and chronic obstructive pulmonary disease in European and East Asian population. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-24 Guo Zhen Fan,Ke Yang Chen,Xiao Meng Liu,Zheng Hai Qu
Objective The present study aimed to explore the potential causal relationship between childhood asthma and chronic obstructive pulmonary disease (COPD) in European and East Asian populations with Mendelian randomization (MR) analysis. Methods Based on summary data from genome-wide association studies, single nucleotide polymorphisms (SNPs) associated with childhood asthma were used as instrumental
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Promoting patient-centred care in the management of allergic rhinitis in Asia-Pacific countries. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-22 Hiroshi Chantaphakul,De Yun Wang,Tran Thi Thuy Hang,Khizuan Abdul Kadir,Hoang Thi Lam,Cecilia Gretchen Navarro-Locsin,Sira Nanthapisal,Danilo Poblete,Pongsakorn Tantilipikorn,Wong Hui Tong,Dinesh Nagrale,Michaela Lucas
Background Allergic rhinitis (AR) has a high burden of disease in the Asia-Pacific region (APAC). Although guidelines provide recommendations regarding the diagnosis and treatment of AR, it is increasingly being recognised that there are gaps in their implementation. Patient-centred care involves accounting for the specific needs and desires of patients as well as including the patient in the decision-making
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Anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 antibody improves airway inflammation in mice with house dust mite induced asthma. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-22 Sung-Ryeol Kim,Yun Jung Um,Sook In Chung,Kyoung Yong Jeong,Hye Jung Park,Kyung Hee Park,Jung-Won Park,Sang Gyu Park,Jae-Hyun Lee
Background Several biologics have been developed and used to treat severe asthma. However, commercialized biologics have limitations in treating T2-low asthma because their main target is the T2 inflammation marker. Therefore, there is an unmet need for treating T2-low severe asthma. Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) is an auxiliary protein in the mammalian multi-aminoacyl-tRNA
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Penicillin allergy delabeling has a significant impact on subsequent antibiotic use in primary care. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-22 Sara Fransson,Jonas B Boel,Holger F Mosbech,Lene H Garvey
Efforts to delabel penicillin allergic patients are important as the majority of suspected penicillin allergy can be ruled out by relevant allergy testing. The aim is to change the antibiotic pattern in delabeled patients to minimize use of unnecessary broad-spectrum antibiotics, reducing the risk of antimicrobial resistance and making treatment more cost effective. However, published information on
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Serum Galectin-10: A biomarker for persistent airflow limitation in adult asthmatics. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-21 Thi Bich Tra Cao,Quang Luu Quoc,Jae-Hyuk Jang,Eun-Mi Yang,Min Sook Ryu,Youngwoo Choi,Hae-Sim Park
Background Inhaled corticosteroids (ICS) are primary anti-inflammatory medications to control eosinophilic airway inflammation, and prevent asthma exacerbation. However, persistent airflow limitation (PAL) presents in some asthmatics even on ICS treatment, leading to lung function decline. Thus, we evaluated clinical associations of serum galectin-10 (Gal10) and galectin-3 (Gal3) levels in adult asthmatics
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Drug provocation tests (DPTs) of contrast media: Useful or not useful? - A narrative review. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-20 Manuel Dettwiler,Ingrid B Boehm
Drug provocation tests (DPTs) are also used in some patients with a history of a contrast medium (CM)-hypersensitivity reaction. Since the use of contrast agents requires special knowledge that is present in radiology but not necessarily in allergology, this overview should close the knowledge gaps. The literature, and the package inserts of the industry dealing with DPTs in contrast hypersensitivity
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Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-20 Hyo-In Rhyou,Hyun-Kyoung Kim,Woo-Jung Song,Sang Min Lee,Sang-Ha Kim,Jae-Woo Kwon,Han-Ki Park,Hye-Kyung Park,Sang Hoon Kim,Jeong-Hee Choi,Sujeong Kim,So-Young Park,Sae-Hoon Kim,Ji-Yong Moon,Jae-Woo Jung,Young-Joo Cho,Chan Sun Park,Byung Keun Kim,Joo-Hee Kim,Min-Suk Yang,Min-Hye Kim,Young-Hee Nam,Taehoon Lee,Byung-Jae Lee,Pankaj Bhavsar,Ian M Adcock,Kian Fan Chung,Tae-Bum Kim
Background Anti-type 2 (T2) biologic therapies (biologics) improve exacerbation rates, lung function, and asthma-related quality of life (QoL) in patients with severe T2 asthma. However, studies comparing different biologics are lacking. We evaluated the QoL in patients with severe asthma comprehensively and compare the efficacy of different T2-directed biologics using QoL questionnaires. Methods We
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Twenty-five years: The fexofenadine clinical experience. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-20 Robert M Naclerio,Ignacio J Ansotegui,Giorgio Walter Canonica,Philip Rouadi,Luo Zhang,Margarita Murrieta-Aguttes
Allergic rhinitis (AR) and urticaria affect a sizable portion of the population worldwide, resulting in reduced quality-of-life and productivity and increased healthcare costs. Fexofenadine (FEX) is a non-sedating second-generation H1 antihistamine with pronounced efficacy and a very good safety profile, used for the treatment of allergic diseases. In addition to its antihistaminic properties, FEX
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Allergic and hypersensitivity condition in the International Patients’ Summary (IPS) standard: The need of updates through the International Classification of Diseases (ICD)-11 World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-20 Luciana Kase Tanno MD PhD, Alain Perie PhD, Jonathan A. Bernstein MD, James L. Sublett MD, Karapet Davtyan MD MPH MBA, Frederic Berard MD PhD, Ruby Pawankar MD PhD, Marylin Valentin Rostan MD, Herberto Chong MD PhD, Anahi Yañez MD, Ignacio J. Ansontegui MD PhD, Motohiro Ebisawa MD PhD, Gary W.K. Wong MD PhD, Mario Morais-Almeida MD, Bryan Martin MD, Yann Briand PhD, Pascal Demoly MD PhD, the American
In 2010, the United States Human and Health Services (US HHS) and the European Union's (EU) Directorate General for Communications Networks, Content and Technology signed a memorandum of understanding to stimulate cooperation surrounding health-related information communications technology. The key project that emerged from this agreement is the (IPS), intended to provide succinct clinically relevant
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Peanut-specific IgG subclasses as biomarkers of peanut allergy in LEAP study participants World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-19 Carolyn H. Baloh MD, Noha Lim, Michelle Huffaker, Pooja Patel, Jody Tversky, George Du Toit MB BCh, Gideon Lack MB BCh, Tanya M. Laidlaw, Donald W. MacGlashan
Antigen-specific IgG2 and IgG3 are rarely measured in food allergy clinical trials despite known function in preventing mast cell and basophil activation. Our objective was to determine whether measuring peanut-specific IgG2 and IgG3 levels would correlate with peanut allergy status. Peanut-specific IgG subclasses were measured via ELISA assays in Learning Early About Peanut allergy (LEAP) trial participants
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The burden of allergic rhinitis is undermanaged in a large proportion of Chinese young adults from Singapore. World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-14 Qi Yi Ambrose Wong,Jun Jie Lim,Jun Yan Ng,Praneeth Malipeddi,Yi Ying Eliza Lim,Yang Yie Sio,Fook Tim Chew
Background Allergic rhinitis (AR) is a nasal disorder characterized by the simultaneous manifestation of at least 2 out of 4 possible symptoms: rhinorrhea, nasal itching, nasal pruritus, and sneezing. Presently, among Chinese young adults from Singapore, we characterised AR phenotypes, established Total Nasal Symptom Score (TNSS) baselines, and examined the management of AR. Methods Participants completed
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World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines update – XVI - Nutritional management of cow's milk allergy World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-12 Carina Venter, Rosan Meyer, Marion Groetch, Anna Nowak-Wegrzyn, Maurizio Mennini, Ruby Pawankar, Rose Kamenwa, Amal Assa'ad, Shriya Amara, Alessandro Fiocchi, Antonio Bognanni, DRACMA Panel, Ignacio Ansotegui, Stefania Arasi, Sami L. Bahna, Roberto Berni Canani, Martin Bozzola, Jan Brozek, Derek Chu, Lamia Dahdah, Christophe Dupont, Motohiro Ebisawa, Ramon T. Firmino, Elena Galli, Gideon Lack, Haiqi
Cow's milk allergy (CMA) is one of the most common presentations of food allergy in early childhood. Management of CMA involves individualized avoidance of cow's milk and other mammalian milk and foods containing these. Optimal elimination of cow's milk avoidance includes: label reading; information about safe and nutritious substitute foods; appropriate choice of infant formula or a plant-based food;
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Proteomic analysis of cardiovascular disease-associated proteins in Korean patients with moderate-to-severe atopic dermatitis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-08 Seon-Pil Jin MD PhD, Hosu Kim MD, Ji Hwan Moon PhD, Seunghee Kim-Schulze PhD, Yookyung Sophie Chun BS, Hyo Jeong Nam BS, Yoon Ji Bang BS, Ji Su Lee MD PhD, Jung Eun Kim MD PhD, Chung-Gyu Park MD PhD, Hyun Je Kim MD PhD, Dong Hun Lee MD PhD
Cardiovascular diseases (CVDs) have been associated with atopic dermatitis (AD), including in Korean patients. Previous studies on AD have primarily focused on patients of European ancestry, while the Asian endotype exhibits distinct characteristics. This study aimed to characterize the blood proteomic signature of Korean patients with moderate-to-severe AD, with an emphasis on proteins related to
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Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as predictors of refractory anaphylaxis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-08 Le Vinh Nghi MD, Nguyen Hoang Phuc MD, Pham Dang Hai MD PhD
Refractory anaphylaxis poses an ongoing, lethal hypersensitivity response that unpredictably involves multiple organs despite appropriate intramuscular (IM) adrenaline injections. Studies on the association of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) concerning anaphylactic severity have yet to be carried out. The study aimed to evaluate the association between
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Thank You to Our 2023 Reviewers World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-06 Alessandro Fiocchi MD, Mona Al-Ahmad MD
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Does angioedema in patients with chronic spontaneous urticaria impact response to omalizumab? World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-05 Thomas B. Casale MD, Benjamin Trzaskoma MS, Michael Holden MD, Jonathan A. Bernstein MD, Marcus Maurer MD
The presence of angioedema, or deep skin swelling, in addition to hives (wheals) in patients with chronic spontaneous urticaria (CSU) can complicate disease management. There is evidence that omalizumab is effective for patients with CSU with angioedema, but the time to a clinically meaningful response has not been assessed. This analysis examined data from the phase 3, randomized, double-blind ASTERIA
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The Australasian Registry for Severe Cutaneous Adverse Reactions (AUS-SCAR) – Providing a roadmap for closing the diagnostic, patient, and healthcare gaps for a group of rare drug eruptions World Allergy Organ. J. (IF 3.9) Pub Date : 2024-08-05 Fiona James BBiomedSci, Michelle S. Goh MBBS, Sara Vogrin MBiostat, Irvin Ng PhD, Abby P. Douglas PhD, Natasha E. Holmes PhD, Kyra YL. Chua PhD, Joseph De Luca MBBS, Pooja Sharma MD, Celia Zubrinich MPhil, Ar K. Aung MBBS, Douglas Gin MBBS, Belinda Lambros MAdvNursPrac, Chris Baker MBBS, Peter Foley MD, Alvin H. Chong MMed, Francis Thien MD, Jie S. Fok MBBS, John Su MBBS, Laura Scardamaglia MBBS, Andrew
Severe cutaneous adverse reactions (SCAR) are a group of delayed presumed T-cell mediated hypersensitivities associated with significant morbidity and mortality. Despite their shared global healthcare burden and impact, the clinical phenotypes, genomic predisposition, drug causality, and treatment outcomes may vary. We describe the establishment and results from the first Australasian registry for
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Habitual snoring coexisting with respiratory allergies in children: Prevalence and impact on quality of life extending beyond primary snoring World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-30 Suttipong Ittiporn MD, Arachaporn Angsubhakorn MD, Chalisa Tangkanangnukul MD, Kanlaya Prajongdee MSN
Children who have respiratory allergies are more likely to experience sleep disturbances. Persistent sleep-disordered breathing directly contributes to poor symptom control for asthma and allergic rhinitis, including deterioration in quality of life. This study aimed to investigate the prevalence, risk factors of habitual snoring, and the correlation between 18-item obstructive sleep apnea (OSA-18)
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Vascular endothelial growth factor (VEGF) emerging as a mediator of hereditary angioedema (HAE) World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-30 Pedro Giavina-Bianchi MD PhD, Marcelo Vivolo Aun MD PhD, Jorge Kalil MD PhD
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Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-29 Marco Caminati MD, Alessandro Marcon PhD, Rachele Vaia MD, Gianenrico Senna MD, Matteo Maule MD, Pierpaolo Marchetti MD, Jessica Miotti MD, Giuseppe Argentino MD, Francesco Blasi MD PhD, Giorgio W. Canonica MD, Enrico M. Heffler MD PhD, Pierluigi Paggiaro MD, Andrea Vianello MD PhD, Gabriella Guarnieri MD, The SANI study group, Luisa Brussino MD PhD S.S.D.D.U, Cecilia Calabrese MD PhD, Gianna Camiciottoli
Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. We aimed to evaluate whether age acts as an independent determinant of asthma severity, in terms of clinical, functional, and inflammatory profile, and to explore potential cofactors that
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Idiopathic hypereosinophilic syndromes and rare dysimmune conditions associated with hyper-eosinophilia in practice: An innovative multidisciplinary approach World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-25 Marco Caminati MD, Lucia Federica Carpagnano MD, Chiara Alberti MSc, Francesco Amaddeo PhD, Riccardo Bixio MD, Federico Caldart MD, Lucia De Franceschi PhD, Micol Del Giglio PhD, Giuliana Festi MD, Simonetta Friso PhD, Luca Frulloni MD, Paolo Gisondi MD, Mauro Krampera PhD, Giuseppe Lippi PhD, Claudio Micheletto MD, Giorgio Piacentini PhD, Patrick Pinter MD, Maurizio Rossini PhD, Michele Schiappoli
Hypereosinophilic syndromes (HES) represent a group of rare dis-immune conditions characterized by blood hyper-eosinophilia and eosinophilic related burden. Especially the idiopathic subtype (I-HES) is particularly difficult to diagnose because of its heterogeneous clinical presentation, the lack of specific findings on physical exam, lab tools, and imaging informative enough to unequivocally confirm
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Serum exosomal miR-141-3p and miR-3679-5p levels associated with endotype and postoperative recurrence in chronic rhinosinusitis with nasal polyps World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-24 Gang Wang MD, Zizhen Liu MD, Jiabin Zhan MD, Rui Li MD, Yi Ye MD, Yanyan Qi MD, Xin Wei PhD, Jing Zheng PhD
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease. Exosomes were involved in different inflammatory diseases, but their roles in CRSwNP were poorly explored. We collected serum samples from 8 CRSwNP patients and 8 healthy controls (HC) and isolated their exosomes. MiRNA sequencing was performed for the exosome samples and differentially expressed miRNAs were identified
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Genetic prediction of asthma increases multiple sepsis risks: A Mendelian randomization study World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-24 Jihang Luo MD, Puyu Liu MD, Yawen Luo MD
Observational epidemiological studies have indicated a potential association between asthma and sepsis, although the causal relationship between these 2 conditions remains uncertain. To further investigate this relationship, the present study utilized Mendelian randomization (MR) analysis approach to explore the potential links between asthma and various types of sepsis. In a large-scale genome-wide
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Type 2 asthma paediatric patients eligible for dupilumab: An Italian biomarker-based analysis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-24 Giorgio Piacentini MD, Alessandro Fiocchi MD, Gianluigi Marseglia MD, Michele Miraglia Del Giudice MD, Renato Cutrera MD, Rossella Bitonti MSc, Francesca Fanelli MSc, Annalisa Stassaldi MSc, Giuliana Nicolosi MD, Gianluca Furneri MSc
Type 2 inflammation is the principal determinant of asthma in children, and it leads to the downstream activation of eosinophils (EOS), the production of immunoglobulin-E (IgE), and increased levels of fraction of exhaled nitric oxide (FeNO). Dupilumab received the approval for the treatment of uncontrolled severe Type 2 asthma in children. The aim of this analysis was to calculate the Type 2 severe
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Penicillin allergy de-labeling: Adaptation of risk stratification tool for patients and families World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-23 Simonne L. Horwitz MD JD MBA, Ye Shen MPH, Stephanie C. Erdle MD FRCPC, Chelsea Elwood BMScH MSc MD FRCSC, Raymond Mak MD FRCPC, John Jacob PhD MSc MBA, Tiffany Wong MD FRCPC
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The systemic treatments for drug reaction with eosinophilia and systemic symptoms (DRESS) beyond corticosteroids World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-20 Sifan Wang BS, Yuanbo Kang BS, Chunxia He MD, Hongzhong Jin MD
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DiHS), is a severe type of cutaneous adverse reaction. The gold standard therapy for DRESS involves the discontinuation of the culprit drug, supportive therapies, and administration of corticosteroids. However, in cases of primary treatment failure or suboptimal response, there arises
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Comparative efficacy of biologics for patients with inadequately controlled asthma: A network meta-analysis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-18 Hayeon Kim PharmD, Myeong Gyu Kim PhD, Sung-Ryeol Kim MD PhD, Jae-Hyun Lee MD PhD, Youngjoo Byun PhD, Jiwon Park MS, Kyungim Kim PhD
Few studies have evaluated the comparative efficacy of biologics for asthma. This network meta-analysis aimed to compare the efficacy of biologics. This study included randomized controlled trials (RCTs) evaluating the efficacy of a biologic compared to a placebo or another biologic in patients with inadequately controlled asthma despite high-intensity treatment, published by January 6, 2022. Two researchers
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Recent prevalence of allergic rhinitis caused by house dust mites among the pediatric population in Fukui, Japan World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-17 Yoshimasa Imoto MD PhD, Masafumi Sakashita MD PhD, Takahiro Tokunaga MD PhD, Masafumi Kanno MD PhD, Kyoko Saito MD, Anna Shimizu MD, Ayako Maegawa MD, Shigeharu Fujieda MD PhD
Allergic rhinitis (AR) is an IgE-mediated type I allergic chronic nasal disease common among all age groups, including the pediatric population. House dust mites (HDMs) are globally ubiquitous and the most important indoor aeroallergen. However, the recent prevalence of HDM-caused AR (AR-HDM) in Japan remains unknown, especially after the COVID-19 pandemic. The objective of this study was to investigate
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Blood and local eosinophil levels in chronic rhinitis: Observations during seasonal allergen exposure and non-exposure World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-04 Xu Xu MSc, Jingyun Li MD PhD, Xu Zhang MD, Lin Xi MD, Yunbo Gao MD, Xian Li MSc, Yuan Zhang MD PhD, Luo Zhang MD PhD
Allergic rhinitis (AR) is a typical type 2 inflammatory disease and eosinophils play a critical role of cardinal effectors in type 2 inflammation. However, the distribution of eosinophils in patients with different subtypes of rhinitis and the effect of allergen exposure on them remain understudied. The aim of this study was to investigate the characteristics and factors influencing the distribution
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Real-life management of atopic dermatitis patients with an inadequate response to on-label use of dupilumab World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-04 Rémi Strizzolo MD, Julien Seneschal MD PhD, Angèle Soria MD PhD, Delphine Staumont-Sallé MD PhD, Sébastien Barbarot MD PhD, Manuelle Viguier MD PhD, Marie Jachiet MD, Audrey Nosbaum MD PhD, Aude Clément MD, Marie Tauber MD PhD, Stéphanie Mallet MD, Aurélie Du-Thanh MD PhD, the French Atopic Dermatitis Network from the GREAT Research group
In patients with moderate to severe atopic dermatitis (AD) showing an inadequate response to dupilumab 300mg/2weeks, few real-life studies reported the response to alternative regimen maintaining dupilumab.
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Unraveling genetic threads: Identifying novel therapeutic targets for allergic rhinitis through Mendelian randomization World Allergy Organ. J. (IF 3.9) Pub Date : 2024-07-01 Xuerong Huang MD, Ruoyi Shen PhD, Zhi Zheng MD
Allergic rhinitis (AR) is a pervasive global health issue, and currently, there is a scarcity of targeted drug therapies available. This study aims to identify potential druggable target genes for AR using Mendelian randomization (MR) analysis. MR analysis was conducted to assess the causal effect of expression quantitative trait loci (eQTL) in the blood on AR. Data on AR were collected from 2 datasets:
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Patient compliance to sublingual immunotherapy for mite-induced allergic rhinitis: A retrospective study World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-27 Wen-Jin Wan BN, Qiu-Yan Xu MD, Mei-Ping Lu MD PhD, Qian Lyu BN, Zi-Jun Gu MSc, Jing Yuan BN, Xin-Jie Zhu MD, Xin-Yan Cui MD PhD, Qin Xu MSc, Lei Cheng MD PhD
Compliance to sublingual immunotherapy (SLIT) is generally low, resulting in reduced short- and long-term clinical efficacy. Compliance is a critical factor determining the success of allergic rhinitis (AR) treatment. To analyze the compliance of patients with house dust mite (HDM)-induced AR to SLIT and the impact of coronavirus disease 2019 (COVID-19) on compliance. The clinical data of 3117 patients
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General practitioner and patient perspectives on intranasal corticosteroids for allergic rhinitis: Treatment duration and obstacles to adherence, findings from a recent survey World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-25 Désirée E.S. Larenas-Linnemann MD, Pornanan Domthong MD, Renata C. Di Francesco MD PhD, Ruperto González-Pérez MD PhD, Manish Verma MD
Currently, there are no guideline recommendations for the duration of intranasal corticosteroid (INCS) treatment for allergic rhinitis (AR). We aimed to catalogue real-world AR-INCS prescription patterns. This multicenter, non-interventional, cross-sectional study used online general practitioner (GP) and patient surveys from 4 countries. Eligible GPs had 3–35 years of practical experience, regularly
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Safety of 300IR house dust mite sublingual tablet from pooled clinical trial and post-marketing data World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-25 Margitta Worm MD, Pascal Demoly MD PhD, Yoshitaka Okamoto MD PhD, Carmen Vidal MD PhD, Katia Daghildjian PharmD PhD, Kwok Yan MD, Thomas B. Casale MD, Karl-Christian Bergmann MD PhD
The 300IR house dust mite (HDM) sublingual immunotherapy (SLIT) tablet is approved for treatment of HDM-induced allergic rhinitis (AR). To provide a comprehensive review of the 300IR HDM-SLIT tablet safety profile based on randomized controlled trial (RCT) pooled data and post-marketing (PM) pharmacovigilance data. Subjects (5–65 years) with confirmed HDM-AR with or without controlled asthma were treated
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Hereditary angioedema prevalence and satisfaction with prophylaxis in South Australia World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-18 Alexander Troelnikov MBBS, Karen Milburn RN, Pravin Hissaria MBBS MD, Thanh Thao (Adriana) Le MBBS, William Smith MBBS PhD
Hereditary angioedema (HAE) due to deficiency of C1 Inhibitor (C1INH-HAE) is a rare, unpredictable and potentially fatal genetic disorder. There are relatively few systematic population prevalence studies, with reports from various countries of between 1 in 20,000 and 1 in 150,000. and no Australian data. The therapeutic landscape for HAE has changed dramatically in recent years with a focus on highly
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Potential asthma risk factors do not account for global asthma symptom prevalence patterns and time trends in children and adolescents World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-14 Charlotte E. Rutter PhD, Richard J. Silverwood PhD, Neil Pearce PhD, David P. Strachan MD, the Global Asthma Network Study Group
The International Study of Asthma and Allergies in Childhood (ISAAC) and the Global Asthma Network (GAN) conducted a series of global asthma prevalence surveys, between 1990 and 2020, in adolescents aged 13–14 and children aged 6–7 years. We used them to assess whether potential asthma risk factors explain global asthma symptom prevalence trends over this period. We fitted mixed-effects linear regression
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Newborn screening for inborn errors of immunity: The status worldwide World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-13 Herberto José Chong-Neto MD PhD, Nesrine Radwan MD PhD, Antônio Condino-Neto MD PhD, Nelson Augusto Rosário Filho MD PhD, José Antonio Ortega-Martell MD, Zeinab A. El-Sayed MD PhD
Newborn screening (NBS) for the early detection of inborn errors of immunity (IEI) has been implemented in a few countries. The objective of this study was to verify the situation and define obstacles to the implementation of NBS worldwide. A questionnaire was developed by the Inborn Errors of Immunity Committee of the World Allergy Organization (WAO) with 17 questions regarding NBS for IEI in the
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Understanding the burden of food allergy among urban and rural school children from north India World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-13 Shruti Sehgal MD(Hom) MS, Neeraj Gupta MBBS DNB, Priyanka Dadha PhD, Shyama Nagarajan PhD, Ruma Gupta MS, Manju Jain Verma PhD MS, Khalid Ibrahim MS, Lucy A. Bilaver PhD, Christopher Warren PhD, Anil Sachdev MD, Sai R. Nimmagadda MD, Ruchi S. Gupta MD MPH
There is paucity of reliable epidemiological data regarding the burden of food allergy in most developing countries, including India. To provide current estimates of the prevalence and distribution of food allergy among urban and rural school children aged 6–14 years in Delhi and the National Capital Region (NCR) of Khekra in India. A cross-sectional study was conducted from January 2022 to February
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The shape of and applied weight on skin prick lancets critically affect the wheal size in the skin prick test World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-13 Ewa Anna Bartko PhD, Jesper Elberling PhD MD, Holger Mosbech DMSc MD
The global application of the skin prick test (SPT) is attributed to the low costs, easy execution, and approach. Still, the healthcare professionals’ technique and the lancet shape may challenge the standardization of the method. Thus, we investigated the influence of the shape of the lancet and the applied weight on the wheal size of SPT. Two allergic and one non-allergic individual were tested with
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Pru p 3-specific IgE affinity is crucial in severe peach-allergy patients World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-11 JunDa Li PhD, XiLian Yi MM, Kai Guan MD, Jia Yin MM
Peach allergy is common food allergen. Allergen components-specific antibodies of different isotypes in peach-allergy patients are poorly studied. Factors other than Pru p 3-sIgE levels may be related to severe symptoms. To evaluated peach component-specific-IgE, IgG1, and IgG4 characteristics in individuals with and without peach allergy, and Pru p 3-sIgE affinity in patients with different clinical
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House dust mite allergen avoidance strategies for the treatment of allergic asthma: A hypothesis-generating meta-analysis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-11 Frank E. van Boven PhD, Gert-Jan Braunstahl PhD, Lidia R. Arends PhD, Maurits S. van Maaren MD, Wichor M. Bramer PhD, Roy Gerth van Wijk PhD, Nicolette W. de Jong PhD
This study continues the review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), aiming to systematically generate hypotheses on the effectiveness of (sub)strategies for house dust mite allergen avoidance in the treatment of allergic asthma. We used the trials previously analysed by Gøtzsche and Johansen and searched recently published studies. Data on asthma
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Identifying patients at risk of anaphylaxis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-06-11 George DuToit MD, Pete Smith MD, Antonella Muraro MD PhD, Adam T. Fox MD, Graham Roberts DM, Johannes Ring MD, Margitta Worm MD
Anaphylaxis is an acute, potentially fatal, systemic hypersensitivity reaction that warrants prompt diagnosis and management. It continues to be challenging to anticipate who may be at risk of a severe, life-threatening allergic reaction. Anaphylaxis can be caused by a range of allergens, such as certain foods, medications, latex, insect stings, etc. Cofactors that augment the severity of clinical
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Association between asthma and cardiovascular diseases: A longitudinal follow-up study using a national health screening cohort World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-30 Hyo Geun Choi MD PhD, Mi Jung Kwon MD PhD, Ji Hee Kim MD PhD, So Young Kim MD PhD, Joo-Hee Kim MD PhD, Ji Young Park MD, Yong Il Hwang MD PhD, Seung Hun Jang MD PhD
Asthma has been suggested to be a risk factor for cardiovascular diseases (CVDs), although the evidence supporting this relationship is inconclusive. This study aimed to explore the long-term associations between asthma and asthma exacerbations with the occurrence of cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), heart failure (HF), and cerebral stroke, utilizing data from a nationwide
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Challenging dogmas: Intravenous versus oral beta-lactam antibiotic provocation tests World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-24 Gustavo-Jorge Molina-Molina MD, Manuel Gómez-Duque MD, Xavier Vidal Guitart MD PhD, Antònia Agustí Escasany MD PhD, Moisés Labrador-Horrillo MD PhD, Olga Luengo MD PhD, Anna Sala-Cunill, Paula Galvan-Blasco MD, Mar Guilarte MD PhD, Victoria Cardona MD PhD
Drug provocation tests (DPT) are considered the gold standard procedure to ascertain the diagnosis of beta-lactam (BL) allergy. Regarding route of administration, current recommendations prioritize oral challenges, considering them safer, and reserving the intravenous route for drugs for which this is the only formulation. To compare in terms of tolerance and safety two protocols of BL DPT, using an
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Hereditary angioedema classification: Expanding knowledge by genotyping and endotyping World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-23 Pedro Giavina-Bianchi MD PhD, Marcelo Vivolo Aun MD PhD, Mara Giavina-Bianchi MD PhD, Ana Júlia Ribeiro MD, Rosana Camara Agondi MD PhD, Antônio Abílio Motta MD PhD, Jorge Kalil MD PhD
Hereditary angioedema (HAE) encompasses a group of diseases characterized by recurrent, genetically mediated angioedema associated with increased vascular permeability primarily due to bradykinin. The disease poses diagnostic challenges, leading to underdiagnosis and delayed therapy. Severe manifestations include laryngeal and intestinal angioedema, contributing to significant morbidity and mortality
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Reply to: World allergy organization anaphylaxis guidance 2020 World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-22 Blanca Barroso MD, Alicia Gómez-López MD, Diana Betancor MD, Marcela Valverde-Monge MD, Joaquín Sastre PhD
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Pediatric asthma comorbidities: Global impact and unmet needs World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-22 Elham Hossny MD PhD, Yuichi Adachi MD PhD, Eleni Anastasiou MD, Héctor Badellino MD PhD, Adnan Custovic PhD, Rasha El-Owaidy MD PhD, Zeinab A. El-Sayed MD PhD, Ivana Filipovic MD PhD, R. Maximiliano Gomez MD PhD, Ömer Kalayci MD, Peter Le Souëf FRACP MD, Michael Miligkos MD PhD, Mário Morais-Almeida MD PhD, Antonio Nieto MD PhD, Wanda Phipatanakul MD, Ghada Shousha MD PhD, Alvaro Teijeiro MD PhD, Jiu-Yao
Real-world data on the range and impact of comorbid health conditions that affect pediatric asthma are scant, especially from developing countries. Lack of data hinders effective diagnosis, treatment, and overall management of these complex cases. We, hereby, describe the common pediatric asthma comorbid conditions in terms of evidence for association, potential mechanisms of impact on asthma control
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Work-related asthma in adults with severe asthma from the Korean Severe Asthma Registry (KoSAR) World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-22 Youngsoo Lee MD, Sun-Kyung Lee PhD, So-Young Park MD PhD, Min-Hye Kim MD PhD, Sung-Yoon Kang MD PhD, Ga-Young Ban MD PhD, Young-Hee Nam MD PhD, Joo-Hee Kim MD PhD, Chin Kook Rhee MD PhD, Woo-Jung Song MD PhD, Jae-Woo Kwon MD PhD, Taehoon Lee MD PhD, So Ri Kim MD PhD, Heung-Woo Park MD PhD, You Sook Cho MD PhD, Young-Il Koh MD PhD, Kwang-Ha Yoo MD PhD, Byung-Jae Lee MD PhD, Ho Joo Yoon MD PhD, Hae-Sim
Exposure to allergens or irritants in the workplace may affect asthma control and the quality of life (QoL) of patients with asthma. To examine the prevalence and characteristics of work-related asthma (WRA) in adult patients with severe asthma. We analyzed data from the Korean Severe Asthma Registry (KoSAR), which is a nationwide multicenter observational study on severe asthma in Korea. Severe asthma
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Predictive modeling for cow's milk allergy remission by low-dose oral immunotherapy in young children World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-17 Seiko Hirai MD, Kiwako Yamamoto-Hanada MD PhD, Kyongsun Pak PhD, Masako Saito-Abe MD PhD, Tatsuki Fukuie MD PhD, Yukihiro Ohya MD PhD
The effectiveness of slow low-dose oral immunotherapy (SLOIT) for cow's milk (CM) allergy has been reported. Most OIT studies have discussed the target populations over 4 years old. Furthermore, no predicting modeling is reported for CM allergy remission by CM-SLOIT under 4 years of age. We sought to develop a predictive model for CM allergy remission by SLOIT after 3 years in young children who started
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Bayesian analysis suggests independent development of sensitization to different fungal allergens World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-17 Victoria Rodinkova PhD, Serhii Yuriev MD, Vitalii Mokin PhD, Mariia Kryvopustova PhD MD, Dmytro Shmundiak MSc, Mykyta Bortnyk MSc, Yevhenii Kryzhanovskyi PhD, Andrii Kurchenko MD PhD
Fungi are known for their ability to cause allergies, but data on individual sensitization to them are insufficient. The purpose of the study was to carry out a comprehensive analysis of the fungal allergens’ sensitization profile in the Ukrainian population and to determine both population and individual sensitivity to these allergens. We utilized a set of ALEX allergy test data from 20,033 inhabitants
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History of food allergy and where we are today World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-16 Sami L. Bahna MD DrPH
The food allergy (FA) entity went through a long difficult road which led to much delay in its recognition. After long periods of denial and misdiagnosis, it attained its current designation as food hypersensitivity or allergy. This review will briefly address the evolution of the FA entity from the early BC era until our 21st century and highlight the milestones in the main aspects of diagnosis, treatment
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Omalizumab withdrawal outcomes in chronic spontaneous urticaria are linked with baseline IgE and eosinophil levels World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-04 Ramit Maoz-Segal MD, Guy Levenberg B.MED.SC, Tanya Levy MD, Soad Haj-Yahia MD, Ronen Shavit MD, Diti Machnes-Maayan MD, Yulia Lifshitz -Tunitsky MD, Stanely Niznik MD, Irena Offengenden MD, Mona Iancovich-Kidon MD, Nancy Agmon-Levin MD
Chronic Spontaneous Urticaria (CSU) is an immune-mediated skin disease that may require prolonged treatments. Currently, there are no recommendations for treatment discontinuation once CSU symptoms are controlled, particularly among patients primarily diagnosed with severe CSU. In this real-life study we aimed to describe our experience of omalizumab (Oma) treatment withdrawal in CSU and define biomarkers
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An unusually high prevalence of allergic rhinitis at high altitudes in 6–7 year old children – An epidemiological study World Allergy Organ. J. (IF 3.9) Pub Date : 2024-05-04 Ying-Qin Gao BM MMed, Jun Jie Seah MBBS (Hons) MRCS (Eng), Mei-Lan Wang BM MMed, Qing-ping Tang BM MMed, De-Yun Wang MD PhD, Xian-Yun Bi BM MMed, Hua-wei Han BM MMed, Tie-Song Zhang MD, Jing Ma MD
To compare the epidemiology and disease patterns of allergic rhinitis (AR) at 2 different altitudes in children aged 6–7 years, and subsequently to compare with and augment data from international studies. This is a multistage, clustered and stratified random sample study. The study area comprises 2 distinct areas within Yunnan Province, China. Low altitude was represented by Xishuangbanna Prefecture
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Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-21 Chuhan Cheng MSc, Jing Lin MSc, Zihan Zhang MSc, Liyan Zhang MD
Asthma, characterized by recurrent wheezing, breathlessness, chest tightness, and coughing, is a major health concern among children and adolescents worldwide, currently affecting more than 5 million children. The increasing prevalence of obesity and overweight among the pediatric population has made the issue of childhood respiratory health more complex. Compared with children of healthy weight, the
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Soil intake modifies the gut microbiota and alleviates Th2-type immune response in an ovalbumin-induced asthma mouse model World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-14 Mengjie Li PhD, Na Li PhD, Yangyang Dong PhD, Honglin Zhang PhD, Zhimao Bai PhD, Rui Zhang PhD, Zhongjie Fei PhD, Wenyong Zhu PhD, Pengfeng Xiao PhD, Xiao Sun PhD, Dongrui Zhou PhD
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HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-13 So-Young Park MD PhD, So Young Park MD PhD, Sujin Seo BS, Hyouk-Soo Kwon MD PhD, Seung-Hyun Kim PhD, Sae-Hoon Kim MD PhD, Hye-Kyung Park MD PhD, Yoon-Seok Chang MD PhD, Cheol-Woo Kim MD PhD, Byung Jae Lee MD PhD, Hae-Sim Park MD PhD, You Sook Cho MD PhD, Heung-Bum Oh PhD, David A. Ostrov PhD, Sungho Won PhD, Tae Bum Kim MD PhD
Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to predict this hypersensitivity reaction. We aimed to evaluate the possible involvement of genes in cefaclor induced type I hypersensitivity. Whole exome sequencing
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Respiratory allergic diseases and allergen immunotherapy: A French patient survey before and during the COVID-19 pandemic World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-10 Philippe Devillier MD PhD, Sarah Saf MD, Christine Rolland BA, Giorgio Walter Canonica MD, Pascal Demoly MD PhD
The COVID-19 pandemic brought unprecedented global disruption to both healthcare providers and patients with respiratory allergies. There are limited real-life data on the impact of the COVID-19 pandemic on the risk perception of patients with allergy treated with allergen immunotherapy (AIT). To understand the risk perception of allergic patients treated with sublingual immunotherapy (SLIT) before
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Association between lipid-lowering drugs and allergic diseases: A Mendelian randomization study World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-10 Yinsong Xu MM, Yuanzhi Li MD
Several observational studies suggest a possible link between lipid-lowering drugs and allergic diseases. However, inferring causality from these studies can be challenging due to issues such as bias, reverse causation, and residual confounding. To investigate the potential causal effect of lipid-lowering drugs, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and 3-hydroxy-3-methyl-glutaryl-coenzyme
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Different doses and courses of omalizumab for patients with chronic spontaneous urticaria: A systematic review with meta-analysis and trial sequential analysis World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-10 Haiyan Qin MD, Xianjun Xiao MD PhD, Di Qin MD, Peiwen Xue MD, Huilin Liu MD, Ying Li MD PhD, Yunzhou Shi MD PhD
The stability, efficacy, and safety of omalizumab at different doses and regimens for chronic spontaneous urticaria (CSU) are yet to be studied. A systematic review (SR) with meta-analysis (MA) and trial sequential analysis (TSA) was performed to assess the efficacy and safety of omalizumab in CSU. Randomised controlled trials (RCTs) of administering omalizumab versus placebo for CSU were searched
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Evaluation of the frequency and characteristics of drug hypersensitivity reactions in hospitalized children: Real life-cohort study World Allergy Organ. J. (IF 3.9) Pub Date : 2024-04-06 Şule Büyük Yaytokgil MD, Ahmet Selmanoglu MD, Ilknur Kulhas Celik MD, Zeynep Şengül Emeksiz MD, Tayfur Ginis MD, Betül Karaatmaca MD, Muge Toyran MD, Ersoy Civelek MD, Emine Dibek Misirlioğlu MD
There are limited data regarding the characteristics and management of drug hypersensitivity reactions (DHR) in hospitalized children. This study aims to determine the prevalence, clinical features, and management of DHRs in pediatric inpatients. Children who had pediatric allergy consultation for suspected DHR during hospitalization in Ankara Bilkent City Hospital between August 1, 2020, and July