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A novel alcohol+nicotine co-use self-administration procedure reveals sex differences and differential alteration of mesocorticolimbic TLR- and cholinergic-related neuroimmune gene expression in rats Alcohol (IF 2.5) Pub Date : 2024-08-27 Christie A. Randall, Dongxiao Sun, Patrick A. Randall
Although alcohol and nicotine are two of the most commonly co-used drugs with upwards of 90% of adults with an alcohol use disorder (AUD) in the US also smoking, we don't tend to study alcohol and nicotine use this way. The current studies sought to develop and assess a novel alcohol + nicotine co-access self-administration (SA) model in adult male and female Long-Evans rats. Further, both drugs are
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The effects of moderate prenatal alcohol exposure on performance in hippocampal-sensitive spatial memory and anxiety tasks by adult male and female rat offspring Alcohol (IF 2.5) Pub Date : 2024-08-08 Gabriela Acosta, Kehiry Trejo Rico, John T. Madden, Ariyana LaCour, Enhui Wang, Lilliana M. Sanchez, Suzy Davies, Carlos Maestas-Olguin, Kayla B. Cox, Nicole C. Reyna, Jeremy Hogeveen, Daniel D. Savage, Nathan S. Pentkowski, Benjamin J. Clark
Moderate prenatal alcohol exposure (mPAE) results in structural alterations to the hippocampus. Previous studies have reported impairments in hippocampal-sensitive tasks, but have not compared performance between male and female animals. In the present study, performance in hippocampal-sensitive spatial memory and anxiety behavior tests were compared across adult male and female saccharin (SACC) control
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Alcohol-induced fibroblast growth factor 21 secretion is increased in individuals with alcohol use disorder Alcohol (IF 2.5) Pub Date : 2024-08-05 Amalie R. Lanng, Lærke S. Gasbjerg, Andrea I.F. Sucksdorff, Jens S. Svenningsen, Tina Vilsbøll, Matthew P. Gillum, Filip K. Knop
Alcohol use disorder (AUD) affects 5% of the global population. Despite its high prevalence, the pathophysiology of AUD remains enigmatic, hindering the development of novel therapeutics. Interestingly, the liver hormone fibroblast growth factor 21 (FGF21), which is currently in late-stage clinical trials for the treatment of non-alcoholic steatohepatitis, has been implicated by recent genome-wide
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Alcohol hangover versus dehydration revisited: The effect of drinking water to prevent or alleviate the alcohol hangover Alcohol (IF 2.5) Pub Date : 2024-07-26 Marlou Mackus, Ann-Kathrin Stock, Johan Garssen, Andrew Scholey, Joris C. Verster
The alcohol hangover is a combination of negative mental and physical symptoms which can be experienced after a single episode of alcohol consumption, starting when blood alcohol concentration (BAC) approaches zero. A popular theory suggests that dehydration is the primary cause of alcohol hangover and that the consumption of water could alleviate hangover symptoms. Here, the current evidence on the
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Sex and sobriety: Human brain structure and function in AUD abstinence Alcohol (IF 2.5) Pub Date : 2024-07-26 Nicole L. Zabik, Jennifer Urbano Blackford
Women are drinking alcohol as much as men for the first time in history. Women experience more health-related consequences from alcohol use disorder (AUD), like increased prevalence of alcohol-related cancers, faster progression of alcohol-related liver disease, and greater risk for relapse compared to men. Thus, sex differences in chronic alcohol use pose a substantial public health problem. Despite
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Emerging pharmacological targets for alcohol use disorder Alcohol (IF 2.5) Pub Date : 2024-07-26 Dakota F. Brockway, Nicole A. Crowley
Alcohol Use Disorder (AUD) remains a challenging condition with limited effective treatment options; however new technology in drug delivery and advancements in pharmacology have paved the way for discovery of novel therapeutic targets. This review explores emerging pharmacological targets that offer new options for the management of AUD, focusing on the potential of somatostatin (SST), vasoactive
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Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion Alcohol (IF 2.5) Pub Date : 2024-07-23 Amanda L. Salazar, Samuel W. Centanni
Alcohol Use Disorder (AUD) is a growing problem worldwide, causing an incredible burden on health and the economy. Though AUD impacts people of all backgrounds and demographics, increasing evidence has suggested robust sex differences in alcohol drinking patterns and AUD-induced negative emotionality or hyperkatifeia. Rates of problematic drinking have significantly risen among women, and women face
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Interneuron-selective HCN channel knockdown in prelimbic cortex of female rats mimics effects of chronic ethanol exposure Alcohol (IF 2.5) Pub Date : 2024-07-19 Benjamin A. Hughes, Todd K. O'Buckley, Giorgia Boero, A. Leslie Morrow
Our laboratory has previously shown that chronic ethanol exposure elicits enhanced working memory performance in female, but not male, adult Sprague–Dawley rats, indicative of a fundamental sex difference in cortical plasticity. Recent studies have furthermore revealed that females display markedly reduced HCN-mediated channel activity in inhibitory Martinotti interneurons after chronic ethanol exposure
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The role of alcohol control policies in the reversal of alcohol consumption levels and resulting attributable harms in China Alcohol (IF 2.5) Pub Date : 2024-07-14 Jürgen Rehm, Kevin Shield, Ahmed S. Hassan, Ari Franklin
Yearly adult consumption of alcohol in China between 2016 and 2019 decreased by 2.4 L of pure alcohol, or 33%. According to the World Health Organization, this decrease in consumption was accompanied by reductions in alcohol-attributable mortality of 23% between 2015 and 2019. This paper examines the contribution of alcohol control policies in China to these public health gains. A systematic search
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Medication development for AUD: A systematic review of clinical trial methodology Alcohol (IF 2.5) Pub Date : 2024-07-05 S. Donato, L.R. Meredith, S.J. Nieto, S. Bujarski, L.A. Ray
Refining clinical trial methodology has become increasingly important as study design is shown to influence treatment efficacy. To maximize the efficiency of randomized clinical trials (RCTs), researchers aim to establish standardized practices. The goal of this systematic review is to describe methodological practices of clinical trials for alcohol use disorder (AUD) over the past 40 years. To achieve
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Exploratory studies of ethanol drinking in the white-tufted marmoset (Callithrix jacchus) Alcohol (IF 2.5) Pub Date : 2024-07-04 Gregg E. Homanics
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Changes in alcohol consumption during the COVID-19 among first-year university students in Spain, considering the risk of problematic use – UniHcos project Alcohol (IF 2.5) Pub Date : 2024-07-03 Lorena Botella-Juan, María Morales-Suárez-Varela, Carmen Amezcua-Prieto, Ramona Mateos-Campos, Carlos Ayán-Pérez, Antonio José Molina, Rocío Ortiz-Moncada, Ana Delgado-Parrilla, Gemma Blázquez-Abellán, Miguel Delgado-Rodríguez, Jessica Alonso-Molero, Tania Fernández-Villa
The aim of this study was to evaluate the possible impact of the COVID-19 pandemic on prevalence rates and self-reported changes in patterns of alcohol use among first-year university students in Spain, considering the risk of problematic alcohol use. A serial cross-sectional study based on the uniHcos project was carried out. Data from 10 518 first-year university students (73.3% female, mean age
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Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice Alcohol (IF 2.5) Pub Date : 2024-06-29 Hernán G. Méndez, Sofia Neira, Meghan E. Flanigan, Harold L. Haun, Kristen M. Boyt, Todd E. Thiele, Thomas L. Kash
While there are numerous brain regions that have been shown to play a role in this AUD in humans and animal models, the central nucleus of the amygdala (CeA) has emerged as a critically important locus mediating binge alcohol consumption. In this study, we sought to understand how relative gene expression of key signaling molecules in the CeA changes during different periods of abstinence following
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Risk of mortality among patients with alcohol-associated hepatitis in the US from 2007 to 2021 Alcohol (IF 2.5) Pub Date : 2024-06-20 Wanzhu Tu, Suthat Liangpunsakul, Chi Mai Nguyen, Ryan Healey, Yang Li, Svetlana Radaeva, Samer Gawrieh, Ramon Bataller, Jing Su
Alcohol-associated hepatitis (AH) mortality and risk factors have not been carefully studied in real-world settings. We examined the rate, temporal trend, and risk factors of mortality in AH. We conducted a cohort study of individuals with AH diagnoses using medical claims data from Optum's Clinformatics® Data Mart (CDM). Participants were individuals covered by Medicare Advantage and commercial insurance
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Heart rate variability: A primer for alcohol researchers Alcohol (IF 2.5) Pub Date : 2024-06-19 Raizel M. Frasier, Thatiane de Oliveira Sergio, Phillip A. Starski, F. Woodward Hopf
Problem alcohol drinking remains a major cost and burden for society. Also, rates of problem drinking in women have dramatically increased in recent decades, and women are at risk for more alcohol problems and comorbidities. The purpose of this commentary is to discuss the potential utility of cardiac measures, including heart rate (HR) and HR variability (HRV), as markers of individual and sex differences
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Dysregulation of neurotrophin expression in prefrontal cortex and nucleus basalis magnocellularis during and after adolescent intermittent ethanol exposure Alcohol (IF 2.5) Pub Date : 2024-06-17 Brian T. Kipp, Polliana T. Nunes, Lisa M. Savage
A preclinical model of human adolescent binge drinking, adolescent intermittent ethanol exposure (AIE) recreates the heavy binge withdrawal consummatory patterns of adolescents and has identified the loss of basal forebrain cholinergic neurons as a pathological hallmark of this model. Cholinergic neurons of the nucleus basalis magnocellularis (NbM) that innervate the prefrontal cortex (PFC) are particularly
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Sex differences in basal motivated behavior, chronic ethanol drinking, and amygdala activity in female and male mice Alcohol (IF 2.5) Pub Date : 2024-06-13 Sarah N. Magee, Allison C. Sereno, Melissa A. Herman
Alcohol use disorder (AUD) is a major public health concern that despite its prevalence, lacks a widely-effective treatment due to the complexity of AUD pathology. AUD is highly comorbid with other psychiatric conditions including anxiety and mood disorders, however it is unclear how these disorders influence each other. The underlying etiology of these comorbidities is difficult to decipher and factors
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Alcohol consumption does not impact delta and kappa opioid receptor-mediated synaptic depression in dorsolateral striatum of adult male mice Alcohol (IF 2.5) Pub Date : 2024-06-08 Braulio Muñoz, Brady K. Atwood
Many drugs of abuse, including alcohol, disrupt long-term synaptic depression (LTD) at dorsal striatal glutamate synapses. This disruption is common to many forms of LTD that are mediated by G protein coupled receptors (GPCRs) that signal through the inhibitory G class of G proteins. A loss of LTD is thought to mediate behavioral changes associated with the development of substance use disorders. We
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Psychometric evaluation of the Chinese version of alcohol relapse risk scale (C-ARRS) in patients with alcohol use disorder Alcohol (IF 2.5) Pub Date : 2024-06-04 I-Ting Lee, Po-Chiao Liao, Tung-Hsia Liu, Yasukazu Ogai, Hu-Ming Chang, Yu-Li Liu, Ming-Chyi Huang
Alcohol use disorder (AUD) is recognized as a chronic relapsing disorder. Alcohol Relapse Risk Scale (ARRS), a multidimensionally self-rating scale, was developed initially by the Japanese to assess the risk of alcohol reuse. The study aimed to validate the reliability and factor structure of the Chinese version of the ARRS (C-ARRS) for patients with AUD. A total of 218 patients diagnosed with AUD
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Causal effect of physical activity and sedentary behavior on the risk of alcohol dependence: A bidirectional two-sample Mendelian randomization study Alcohol (IF 2.5) Pub Date : 2024-05-30 Meiqi Wei, Deyu Meng, Shichun He, Hongzhi Guo, Guang Yang, Ziheng Wang
Alcohol dependence, influenced by physical activity (PA) and sedentary behavior, lacks clear causal clarity. This study aims to clarify causal relationships by estimating these effects using bidirectional two-sample Mendelian randomization (MR). A bidirectional multivariable two-sample MR framework was employed to assess the causal effects of PA and sedentary behavior on alcohol dependence. Summarized
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Phosphatidylethanol in post-mortem brain: Correlation with blood alcohol concentration and alcohol use disorder Alcohol (IF 2.5) Pub Date : 2024-05-17 Caine C. Smith, Julia Stevens, Mario Novelli, Dhiraj Maskey, Greg T. Sutherland
Phosphatidylethanol (PEth) is an alcohol derivative that has been employed as a blood-based biomarker for regular alcohol use. This study investigates the utility of phosphatidylethanol (PEth) as a biomarker for assessing alcohol consumption in post-mortem brain tissue. Using samples from the New South Wales Brain Tissue Resource Centre, we analysed PEth(16:0/18:1) levels in the cerebellum and meninges
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The histamine H3 receptor inverse agonist SAR-152954 reverses deficits in long-term potentiation associated with moderate prenatal alcohol exposure Alcohol (IF 2.5) Pub Date : 2024-05-03 Monica Goncalves-Garcia, Suzy Davies, Daniel D. Savage, Derek A. Hamilton
Prenatal alcohol exposure can have persistent effects on learning, memory, and synaptic plasticity. Previous work from our group demonstrated deficits in long-term potentiation (LTP) of excitatory synapses on dentate gyrus granule cells in adult offspring of rat dams that consumed moderate levels of alcohol during pregnancy. At present, there are no pharmacotherapeutic agents approved for these deficits
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Association between telomere length with alcohol use disorder and internalizing/externalizing comorbidities in a Brazilian male sample Alcohol (IF 2.5) Pub Date : 2024-04-16 Helena Ferreira Moura, Jaqueline Bohrer Schuch, Felipe Ornell, Cibele Edom Bandeira, Raffael Massuda, Claiton Henrique Dotto Bau, Eugenio Horácio Grevet, Felix H.P. Kessler, Lisia von Diemen
Shortening telomere length (TL) is an important ageing marker associated with substance use disorder (SUD). However, the influence of psychiatric and clinical comorbidities and alcohol-related outcomes has not been much explored in the context of TL in individuals with alcohol use disorder (AUD) and may be a source of heterogeneity in AUD studies. Therefore, our aim was to investigate the influence
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Recent alcohol intake impacts microbiota in adult burn patients Alcohol (IF 2.5) Pub Date : 2024-04-10 Andrew J. Hoisington, Kevin Choy, Shanawaj Khair, Kiran U. Dyamenahalli, Kevin M. Najarro, Arek J. Wiktor, Daniel N. Frank, Ellen L. Burnham, Rachel H. McMahan, Elizabeth J. Kovacs
Alcohol use is associated with an increased incidence of negative health outcomes in burn patients due to biological mechanisms that include a dysregulated inflammatory response and increased intestinal permeability. This study used phosphatidylethanol (PEth) in blood, a direct biomarker of recent alcohol use, to investigate associations between a recent history of alcohol use and the fecal microbiota
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Emerging concepts in alcohol, infection & immunity: A summary of the 2023 alcohol and immunology research interest group (AIRIG) meeting Alcohol (IF 2.5) Pub Date : 2024-04-04 Lauren N. Rutt, Mengfei Liu, Esther Melamed, Shannon Twardy, Jamie L. Sturgill, Lisa A. Brenner, Josiah Hardesty, Steven A. Weinman, Madison M. Tschann, Jared Travers, David A. Welsh, Natalie Chichetto, Kathryn M. Crotty, Bryan Mackowiak, Samantha M. Yeligar, Todd A. Wyatt, Rachel H. McMahan, Mashkoor A. Choudry, Elizabeth J. Kovacs, Rebecca L. McCullough
On December 8th 2023, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. The 2023 meeting focused broadly on how acute and chronic alcohol exposure leads to immune dysregulation, and how this contributes to damage in multiple tissues and organs. These include impaired lung immunity, intestinal
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Alcohol-related peripheral neuropathy: Clinico-neurophysiological characteristics and diagnostic utility of the neuropathy symptoms score and the neuropathy impairment score Alcohol (IF 2.5) Pub Date : 2024-04-03 Michail Papantoniou, Michail Rentzos, Thomas Zampelis, Elias Tzavellas, Thomas Paparrigopoulos, Panagiotis Kokotis
Alcohol overconsumption is well known to cause damage to the peripheral nervous system, affecting both small and large nerve fibers. The aim of this descriptive study was to investigate peripheral nerve damage, and to correlate clinical, epidemiological and neurophysiological findings, in patients diagnosed with Alcohol Use Disorder (AUD). Ninety alcohol-dependent subjects on inpatient basis were enrolled
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Adult symptoms of ASD and ADHD in relation to alcohol use: Potential roles of transdiagnostic features Alcohol (IF 2.5) Pub Date : 2024-03-27 Michael Lyvers, Saraid Dark, Irene Jaguru, Fred Arne Thorberg
Attention Deficit Hyperactivity Disorder (ADHD) is the most common comorbidity in Autism Spectrum Disorder (ASD). ADHD is a risk factor for alcohol misuse whereas ASD is often regarded as protective; however, research on ASD and alcohol use has yielded conflicting findings, sometimes implicating the role of comorbid ADHD. The possibility that certain transdiagnostic features (i.e., characteristics
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The decrease in alcohol consumption and suicide rate during the COVID-19 pandemic and their association Alcohol (IF 2.5) Pub Date : 2024-03-26 Agnus M. Kim, Jin-Seok Lee
Despite the considerable change in alcohol consumption during the COVID-19 pandemic, the impact of the pandemic on the suicide rate in terms of alcohol consumption was not studied. This study was performed to examine whether the change in the suicide rate during the COVID-19 pandemic was related to alcohol consumption and whether the relation was specific to suicides when compared to mortality due
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Pain in alcohol use disorder: Evaluating effects of childhood trauma, perceived stress, and psychological comorbidity Alcohol (IF 2.5) Pub Date : 2024-03-26 M.L. Schwandt, V.A. Ramchandani, J. Upadhyay, C. Ramsden, N. Diazgranados, D. Goldman
The relationship between pain and alcohol use disorder (AUD) is complex and bidirectional. The current study examines risk factors for pain in a large comprehensively phenotyped sample including individuals from across the spectrum of alcohol use and misuse. Participants (n = 1101) were drawn from the National Institute on Alcohol Abuse and Alcoholism Natural History Protocol and included treatment-seeking
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Effects of moderate ethanol exposure on risk factors for cardiovascular disease and colorectal cancer in adult Wistar rats Alcohol (IF 2.5) Pub Date : 2024-03-24 Anna J. Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M. Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of
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Alcohol: Epigenome alteration and inter/transgenerational effect Alcohol (IF 2.5) Pub Date : 2024-03-18 Nazila Heidari, Arman Hajikarim-Hamedani, Amirhossein Heidari, Yekta Ghane, Ghorbangol Ashabi, Mohammad-Reza Zarrindast, Mitra-Sadat Sadat-Shirazi
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Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7 Alcohol (IF 2.5) Pub Date : 2024-03-11 Cindy L. Ehlers, Libo Li, Qian Peng, David A. Gilder, Kathryn R. Batts, Katherine J. Karriker-Jaffe
To understand why some individuals who develop alcohol use disorders (AUD) first begin to drink heavily, a number of scales have been developed that index aspects of alcohol craving and restraint from drinking. We developed a new measure called the Alcohol Consumption Questionnaire (ACQ), based in part on items modified from scales used to index binge eating, because there are data to suggest that
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Surgical incision pain induced an increase in alcohol consumption in mice Alcohol (IF 2.5) Pub Date : 2024-03-11 Sofia Ghani, Yasmin Alkhlaif, Jared Mann, Lauren Moncayo, Esad Ulker, Martial Caillaud, Mitali Barik, Joseph W. Ditre, Michael F. Miles, M. Imad Damaj
Large population-based studies have suggested a link between increased alcohol use and reduced pain. In addition, these studies suggest that higher levels of pain intensity are associated with an increase in alcohol consumption and rates of hazardous drinking which potentiates the risk of developing alcohol use disorders (AUD). The mechanisms and determinants of the alcohol–pain interaction can be
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Alcohol Treatment Preferences and the Acceptability of Virtual Reality Therapy for Treating Alcohol Misuse in Adult Drinkers Alcohol (IF 2.5) Pub Date : 2024-03-09 Dr. Rigina Skeva, Prof. Caroline Jay, Prof. Steve Pettifer, Dr. Lynsey Gregg
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THE TRENDS AND INCIDENCE OF ALCOHOL-ASSOCIATED HEPATITIS HOSPITALIZATIONS FROM 2016-2020 AND THE IMPACT OF THE COVID-19 PANDEMIC Alcohol (IF 2.5) Pub Date : 2024-03-08 Megan B. Ghai MD MPH MA, Pooja Rangan MBBS MPH, Naim Alkhouri MD, Jessica Mellinger MD MSc, Karn Wijarnpreecha MD MPH
The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016-2020 and evaluate demographic disparities including sex and race. A retrospective analysis of the 2016-2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020
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Patients with alcohol abuse have higher risks of complications after coronary artery bypass grafting: A population-based study of National Inpatient Sample from 2015 to 2020 Alcohol (IF 2.5) Pub Date : 2024-03-05 Renxi Li, Deyanira J. Prastein
Alcohol abuse (AA) has s high prevalence, affecting 10 to 15 million Americans. While AA was demonstrated to negatively impact cardiovascular health, limited evidence from existing studies presents conflicting findings regarding the effects of AA on coronary artery bypass grafting (CABG) outcomes. This study aimed to compare the in-hospital outcomes after CABG between AA and non-AA patients. Patients
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Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study Alcohol (IF 2.5) Pub Date : 2024-03-01 Seongyeon Cho, Jiwon Jeong, Sangah Shin
Alcohol consumption is a significant public health concern in Korea, with many individuals engaging in risky drinking behaviors. This study aims to analyze the association between facial flushing responses and the progression of hypertension in Korean adults, stratified by gender, using a large-scale prospective cohort study. This study included 39,868 participants (males 10,868 and females 29,000)
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Performance on a relational integration task is impaired during hangover Alcohol (IF 2.5) Pub Date : 2024-02-28 Craig Gunn, Tom Crosby, Alice Nanton, Livi Gorvin
Recently, researchers have proposed an updated model of executive functions that includes relational integration, the mental ability to bind information into more complex structures. Hangover is known to disrupt other core components of executive functions, but little is known about how it influences relational integration. Therefore, this study aimed to investigate how hangover influences performance
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The effect of developmental alcohol exposure on multisensory integration is larger in deeper cortical layers Alcohol (IF 2.5) Pub Date : 2024-02-28 Dongil Keum, Alexandre E. Medina
Fetal Alcohol Spectrum Disorders (FASD) are one of the most common causes of mental disability in the world. Despite efforts to increase public awareness of the risks of drinking during pregnancy, epidemiological studies indicate a prevalence of 1-6% in all births. There is growing evidence that deficits in sensory processing may contribute to social problems observed in FASD. Multisensory (MS) integration
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Burden of alcohol use and inclusion of alcohol use disorder medications in the essential medicine lists across 132 countries: An observational study Alcohol (IF 2.5) Pub Date : 2024-02-27 Arpit Parmar, Dinesh Prasad Sahu, Priyamadhaba Behera
Harmful use of alcohol effects the health of the population. The treatment coverage of alcohol use disorders (AUD) varies among countries. The study aimed to determine the inclusion of AUD medicines in various national Essential Medicine Lists (EMLs) and its association with alcohol consumption. It was a secondary data analysis of alcohol consumptions and AUD related medicines in EML. Data were extracted
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Acute and chronic alcohol modulation of extended amygdala calcium dynamics Alcohol (IF 2.5) Pub Date : 2024-02-27 Alison V. Roland, Tzu-Hao Harry Chao, Olivia J. Hon, Samantha N. Machinski, Tori R. Sides, Sophia I. Lee, Yen-Yu Ian Shih, Thomas L. Kash
The central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) are reciprocally connected nodes of the extended amygdala thought to play an important role in alcohol consumption. Studies of immediate-early genes indicate that BNST and CeA are acutely activated following alcohol drinking and may signal alcohol reward in nondependent drinkers, while stress signaling in the extended amygdala
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Health Disparities in Time to Diagnosis and Survival Post-Diagnosis of Cirrhosis in Individuals with Alcohol Use Disorder: A Retrospective Cohort Study Alcohol (IF 2.5) Pub Date : 2024-02-24 Raphael E. Cuomo
This study investigates the impact of race, gender, and ethnicity on the progression from diagnosis to cirrhosis and subsequent survival in patients with alcohol use disorder, with a specific focus on identifying potential disparities in health outcomes. Employing a STROBE-compliant, retrospective cohort design, we analyzed data from patients diagnosed with alcohol use disorder from January 2000 to
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A rapid procedure to assess shifts in discriminative control over drinking during recovery-like behavior Alcohol (IF 2.5) Pub Date : 2024-02-21 Acacia Nawrocik-Madrid, Hanana AlTfaili, R.J. Lamb, Brett C. Ginsburg
Previously, we reported that recovery-like behavior decreases stimulus control over drinking, and this likely plays a role in the clinical observation that longer recovery increases relapse resistance. Those studies were conducted using a procedure that required repeated assessment, preventing a longitudinal analysis of the changes in stimulus control over time in each individual. Here we recapitulate
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Effects of alcohol on the composition and metabolism of the intestinal microbiota among people with HIV: A cross-sectional study Alcohol (IF 2.5) Pub Date : 2024-02-20 Ni-ni Qiao, Quan Fang, Xin-hong Zhang, Su-su Ke, Zi-wei Wang, Gan Tang, Rui-xue Leng, Yin-guang Fan
Alcohol consumption is not uncommon among people with HIV (PWH) and may exacerbate HIV-induced intestinal damage, and further lead to dysbiosis and increased intestinal permeability. This study aimed to determine the changes in the fecal microbiota and its association with alcohol consumption in HIV-infected patients. A cross-sectional survey was conducted between November 2021 and May 2022, and 93
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Theory of Planned Behavior and alcohol use in adolescents in Ecuador. Structural linear regression analysis Alcohol (IF 2.5) Pub Date : 2024-02-13 Rodrigo Moreta-Herrera, Sheyla Córdova-Sánchez, Ana Jaramillo-Zambrano, Ana Paredes-Proaño, Guido Mascialino, Claudio Rojas-Jara, Alberto Rodríguez-Lorenzana
The general aim is to identify the explanatory potential of alcohol use intentions in drinking behaviors in a sample of adolescents in Ecuador. The method consists of a descriptive, explanatory, and cross-sectional study using SEM techniques. The participants were 384 adolescents (57% male and 43% female), aged 14–18 years (M = 16.51; SD = 2.64), who are students attending between the 1st and 3rd year
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Examination of factors related to problem drinking among the working population: The Japanese civil servants study Alcohol (IF 2.5) Pub Date : 2024-02-08 Takashi Shigeno, Takashi Tatsuse, Michikazu Sekine, Masaaki Yamada
Problem drinking affects not only the health of a population but also the productivity of a nation, especially if it is rampant among the working population. This study examines the association between problem drinking and work characteristics, work-family status, and social situations among the Japanese working population. Multivariable logistic regression analysis was performed on the basis of gender
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Engagement for Alcohol Escalates in the 5-Choice Serial Reaction Time Task After Intermittent Access Alcohol (IF 2.5) Pub Date : 2024-01-28 Phillip Starski, Addyson Siegle, Frederic Hopf
Excessive intake plays a significant role in the development of alcohol use disorder and impacts 15 million Americans annually, with approximately 88,000 dying from alcohol related deaths. Several facets we contribute to alcohol use disorder include impulsivity, motivation, and attention. Previous studies have used the 5-Choice Serial Reaction Time Task (5-Choice) to analyze these types of behaviors
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Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague–Dawley rats Alcohol (IF 2.5) Pub Date : 2024-01-28 Florian Duclot, Lizhen Wu, Courtney S. Wilkinson, Mohamed Kabbaj, Lori A. Knackstedt
Ceftriaxone is an antibiotic that increases central nervous system (CNS) protein expression of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in rodent models of neurological disease and substance use disorder. However, little ceftriaxone passes through the blood–brain barrier, the CNS binding partner of ceftriaxone is unknown, and ceftriaxone does not consistently
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Circulating microRNA profiling identifies microRNAs linked to prediabetes associated with alcohol dependence syndrome Alcohol (IF 2.5) Pub Date : 2024-01-22 Palaniswamy Ramaswamy, Athira S V, Pratibha Misra, V.S. Chauhan, Arka Adhvaryu, Anurodh Gupta, Ankita G, Sibin M K
Background MicroRNAs are abundant in serum and have emerged as important regulators of gene expression, implicating them in a wide range of diseases. The purpose of this study was to discover and validate serum miRNAs in prediabetes associated with alcohol dependence syndrome (ADS). Method Serum samples from ADS patients with or without prediabetes and normoglycemic controls were subjected to microarray
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Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder Alcohol (IF 2.5) Pub Date : 2024-01-24 Olli Kärkkäinen, Tommi Tolmunen, Petri Kivimäki, Karoliina Kurkinen, Toni Ali-Sisto, Pekka Mäntyselkä, Minna Valkonen-Korhonen, Heli Koivumaa-Honkanen, Kirsi Honkalampi, Anu Ruusunen, Vidya Velagapudi, Soili M. Lehto
Our aim was to evaluate whether alcohol use is associated with changes in the circulating metabolite profile similar to those present in persons with depression. If so, these findings could partially explain the link between alcohol use and depression. We applied a targeted liquid chromatography mass spectrometry method to evaluate correlates between concentrations of 86 circulating metabolites and
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Investigation of serum BDNF levels in alcohol withdrawal syndrome with and without other medical co-morbidities Alcohol (IF 2.5) Pub Date : 2024-01-17 Marta Malinowska-Kubiak, Magda Malewska-Kasprzak
Abstract not available
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Occurrence and correlates of domestic violence among asian patients with alcohol use disorder seeking treatment for cessation Alcohol (IF 2.5) Pub Date : 2024-01-06 Wen-Yu Hsu
Alcohol use disorder (AUD) has significant social and economic consequences in addition to health implications. Alcohol and drug use are linked to violence, particularly intimate partner violence and domestic violence. Identifying the characteristics of individuals with AUD and a history of domestic violence is important. Our study aimed to investigate differences between AUD patients with and without
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Stress-enhanced ethanol drinking does not increase sensitivity to the effects of a CRF-R1 antagonist on ethanol intake in male and female mice Alcohol (IF 2.5) Pub Date : 2024-01-05 Michelle A. Nipper, Melinda L. Helms, Deborah A. Finn, Andrey E. Ryabinin
Research confirms that stress is associated with alcohol drinking and relapse in males and females and that there are sex differences in the alcohol-related adaptations of stress pathways. The predator stress (PS) model of traumatic stress produces an increase in alcohol drinking or self-administration in a subpopulation of rodents, so it is utilized as an animal model of comorbid alcohol use disorder
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The relationship between male prisoners’ self-efficacy and their participation in addiction treatment Alcohol (IF 2.5) Pub Date : 2023-12-30 Beata Pastwa-Wojciechowska, Klaudia Guzińska
The purpose of this study was to attempt to verify the existence of a relationship between internal resources (self-esteem and self-efficacy) and motivation (decisional balance) to undergo treatment in prisoners with alcohol addiction participating in voluntary treatment as well as referred to obligatory addiction treatment based on a court decision. The study was carried out in penitentiary units
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Associations between sleep medication use and alcohol consumption over 36 years in Finnish twins Alcohol (IF 2.5) Pub Date : 2023-12-14 Viola Helaakoski, Stephanie Zellers, Christer Hublin, Hanna M. Ollila, Antti Latvala
Background Sleep medication use is an indicator of underlying sleep problems that might be induced by various factors such as alcohol use. However, the longitudinal relationship between drinking and sleep problems remains poorly understood. We investigated associations between sleep medication and alcohol use throughout adulthood, and examined the role of familial and potential confounding factors
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Sexual alcohol expectancies moderate the relation between alcohol use and sexual behavior among men who have sex with men Alcohol (IF 2.5) Pub Date : 2023-12-14 Grace E. Murray, Tibor P. Palfai, Maya P.L. Kratzer, Stephen A. Maisto, Jeffrey S. Simons
HIV transmission remains a significant health concern for men who have sex with men (MSM) in the United States. Heavy episodic drinking (HED) is related to increased rates of condomless anal intercourse (CAI) among MSM, though evidence suggests that this association may vary by individual difference factors. The present secondary analysis tested whether sexual alcohol expectancies (SAEs) moderate the
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Recent breakthroughs in understanding the cerebellum's role in fetal alcohol spectrum disorder: A systematic review Alcohol (IF 2.5) Pub Date : 2023-12-13 Eric C.H. Leung, Priyanka Jain, Marisa A. Michealson, Hyesun Choi, Alexis Ellsworth-Kopkowski, C. Fernando Valenzuela
Exposure to alcohol during fetal development can lead to structural and functional abnormalities in the cerebellum, a brain region responsible for motor coordination, balance, and specific cognitive functions. In this systematic review, we comprehensively analyze a vast body of research conducted on vertebrate animals and humans over the past 13 years. We identified studies through PubMed and screened
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Why do men with drinking problems change their behavior? A qualitative study nested in a randomized controlled trial in India Alcohol (IF 2.5) Pub Date : 2023-12-12 Urvita Bhatia, Richard Velleman, Abhijit Nadkarni, Sachin Shinde, Aarushi Shah, Vikram Patel
The aim of this qualitative study, nested in a randomized controlled trial, was to assess the mechanisms of the effects in both arms through examining perceptions of the participants about changes in their drinking behavior and their attributions for any perceived changes. We conducted semi-structured interviews with a sub-sample of trial participants. We used thematic analysis to analyze the data