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Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-20 Emma L Campbell,Wei C G Fong,Amanda Roberts,Kim S Thomas
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Global, regional, and national burdens of acne vulgaris in adolescents and young adults aged 10-24 years from 1990 to 2021: a trend analysis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-13 Zhou Zhu,Xiaoying Zhong,Zhongyu Luo,Mingjuan Liu,Hanlin Zhang,Heyi Zheng,Jun Li
BACKGROUND Acne vulgaris is a common skin condition affecting adolescents and young adults worldwide, yet data on its burden and trends remain limited. We aimed to investigate trends in the burden of acne vulgaris among adolescents and young adults aged 10-24 years at global, regional, and national levels. METHODS We retrieved data from the Global Burden of Disease Study (GBD) 2021 for individuals
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Single cell analyses of cutaneous T-cell lymphoma biopsies. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-13 Cornelis P Tensen,Maarten H Vermeer
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Single high dose vitamin D3: a promising sunburn therapy. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-13 John A McGrath,Kurt Q Lu
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Hidden hurts: life with lichen sclerosus - a patient perspective. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-12 Elena Galentine,Camille M Powers,Leah McAleer,Sydney Rivera,Melissa M Mauskar
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The use of Reflectance Confocal Microscopy to diagnose Basal Cell Carcinoma in the United Kingdom: A Prospective Observational Trial at a Single Centre. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-11 Howard P Stevens,Riccardo Pampena,Francesca Farnetani,Giovanni Pellicani,Colin Angus,Joseph N El-Jabbour
BACKGROUND Previous work with Reflectance Confocal Microscopy (RCM) imaging has shown high sensitivity and specificity for Basal Cell Carcinoma (BCC), but to date there have been few studies on a UK cohort. OBJECTIVES The study hypothesised that RCM could be used prospectively to accurately diagnose BCC in a private UK secondary care, single clinician setting. The study assessed the potential for RCM
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The use of Reflectance Confocal Microscopy to diagnose Malignant Melanoma and Lentigo Maligna in the United Kingdom: A Prospective Observational Trial at a Single Centre. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-10 Howard P Stevens,Giovanni Pellacani,Colin Angus,Joseph N El-Jabbour
BACKGROUND Previous work with Reflectance Confocal Microscopy (RCM) imaging has shown high sensitivity and specificity for Malignant Melanoma (MM), but to date there have been no studies on a UK cohort. OBJECTIVES The study hypothesised that RCM could be used prospectively to accurately diagnose MM and lentigo maligna (LM) in a private UK secondary care, single clinician setting. The study assessed
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Polarization of circulating Follicular Helper T cells correlates with the severity of Bullous Pemphigoid. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-10 Corine Pérals,Sébastien le Jan,Céline Muller,Richard Le Naour,Philippe Bernard,Manuelle Viguier,Nicolas Fazilleau
BACKGROUND T-follicular-helper (Tfh) cells form a distinct population of T-helper cells with different polarizations (type 1, type 2 and type 17) that regulates humoral responses and may participate in the pathophysiology of B-cell mediated autoimmune diseases, such as bullous pemphigoid (BP), a dermatosis mediated by auto-antibodies specific for hemidesmosomal proteins. OBJECTIVES The aim was to evaluate
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A Practical Guide to Using Oral JAK Inhibitors for Atopic Dermatitis from the International Eczema Council. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-10 Carter Haag,Andrew Alexis,Valeria Aoki,Robert Bissonnette,Andrew Blauvelt,Raj Chovatiya,Michael J Cork,Simon G Danby,Lawrence Eichenfield,Kilian Eyerich,Melinda Gooderham,Emma Guttman-Yassky,Dirk-Jan Hijnen,Alan Irvine,Norito Katoh,Dedee F Murrell,Yael A Leshem,Adriane Levin,Ida Vittrup,Jill I Olydam,Raquel L Orfali,Amy Paller,Yael Renert-Yuval,David Rosmarin,Jonathan Silverberg,Jacob Thyssen,Sonja
BACKGROUND Janus kinase inhibitors (JAKinibs) have the potential to dramatically alter the landscape of atopic dermatitis (AD) management due to their promising efficacy results from phase 3 trials and rapid onset of action. However, JAKinibs are not without risk, and their use is not appropriate for all AD patients, making this a medication class that dermatologists should understand and consider
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The emerging burden of melanoma overdiagnosis in Australia: Who bears the cost-patients or the healthcare system? Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-09 Rashidul Alam Mahumud
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Role of albinism and pigment-related genes in amelanotic melanoma formation. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-09 Valentina Posada,Amanda E Toland
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The association between prescribed oral anti-diabetic medication for type 2 diabetes mellitus and skin cancer risk: a systematic review and meta-analysis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-06 Corey Simpson,Sophie Leducq,Zoe Venables,Zenas Z N Yiu,Lesley E Rhodes,Iskandar Idris,Sonia Gran
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An expert consensus on managing dupilumab-related ocular surface disorders in people with atopic dermatitis 2024. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-05 Michael R Ardern-Jones,Sara J Brown,Carsten Flohr,Parwez Hossain,Alan D Irvine,Graham A Johnston,Mark Lane,Sinéad M Langan,Philip Laws,Daniel O'Driscoll,Donal O'Kane,Alice Payne,Gabriela Petrof,Andrew E Pink,Saaeha Rauz,Scott Robbie,Sri K Gore,Mili Shah,Richard T Woolf,Chenxi Wang,Stoyana Tumbeva,M Firouz Mohd Mustapa
BACKGROUND Atopic dermatitis (AD) is the most common inflammatory skin condition which affects all ages. New therapies, including the monoclonal antibody therapy dupilumab, offer excellent efficacy. However, in clinical trials, and emphasised in real-world observations, the unexpected increased frequency of ocular adverse effects became apparent. The effectiveness of dupilumab and the unpredictability
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Exploring sex and site- specific differences in melanoma. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-04 Alan C Geller,Alexander J Stratigos
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Silencing siRNA microneedle patches versus silicone sheets in reducing post-surgical scars: a randomized single-blinded intra-individually controlled clinical trial. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-04 Delwyn Zhi Jie Lim,Yong Yao Chun,Amelia Yuting Monteiro,Hui Mei Cheng,Jia Yi Lee,Yingrou Tan,Timothy T Y Tan,Hong Liang Tey
BACKGROUND A common complication of wounds is exuberant growth of fibrotic scar tissue, which can lead to hypertrophic scars or keloids. There are currently no treatments with good evidence for preventing excessive scar tissue formation. In this study, we explored the use of microneedle patches containing siRNA inhibiting SPARC mRNA in reducing the volume of post-surgical scars. OBJECTIVE We aim to
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Management of dupilumab-related ocular surface disorders. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-04 Tina Felfeli,Aaron M Drucker
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Mycosis Fungoides - an unwelcome guest in my life. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-09-04 Cristina Grechin,Li Jie Helena Yoo,Stephanie Lynn Ryan,Síona Ní Raghallaigh
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Decreased serum levels of IL-4 correlate with the efficacy of the PAI-1 inhibitor TM5614 in patients with malignant melanoma refractory to anti-PD-1 antibodies: post hoc study of TM5614-MM trial. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-31 Emi Yamazaki,Taku Fujimura,Manami Takahashi-Watanabe,Satsuki Tada,Chisako Kitayama,Ryo Amagai,Yumi Kambayashi,Masahiro Watanabe,Masamitsu Maekawa,Nariyasu Mano,Yoshihide Asano
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Photodynamic therapy reduces the burden of small ultraviolet-induced epidermal clones in human and mouse skin. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-27 Lei Wei,Megan E Fitzgerald,Li Yan,Mitsuko Murakami,Sydney R Grant,Qiang Hu,Serena Fan,Bernard Okai,Divya Goyal,Prashant K Singh,Gal Shafirstein,Eva Remenyik,Emese Gellen,Barbara A Foster,Wendy J Huss,Gyorgy Paragh
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Clinically mild hidradenitis suppurativa: mild for whom? Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-26 Tonia Samela,Giulia Raimondi,Giusi Pintori,Maria Beatrice Pupa,Giorgia Cordella,Valeria Antinone,Nidia Melo Salcedo,Roberta Fusari,Sabatino Pallotta,Francesca Sampogna,Luca Fania,Giovanni Pellacani,Damiano Abeni
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'Psycholag': a new term to describe the delay between physical and psychological improvement in patients with skin disease. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-22 Alia Ahmed,Padma Mohandas,Ruth Taylor,Iyas Assalman,Anthony Bewley
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Association of Genetic Alterations with Prognosis in Extramammary Paget's Disease: Insights into the Involvement of somatic CDKN2A variants in Poor Prognosis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-22 Okuto Iwasawa,Masachika Ikegami,Takuya Miyagawa,Hiromichi Morita,Hinako Saito,Issei Omori,Kentaro Awaji,Jun Omatsu,Daisuke Yamada,Hidenori Kage,Katsutoshi Oda,Shinichi Sato,Hayakazu Sumida
BACKGROUND Previous studies reported the mutational landscape in extramammary Paget's disease (EMPD); however, the prognostic implications of genetic alterations remain unexplored. While CDKN2A loss is known to be associated with tumor progression or poor prognosis in some types of cancer, its significance in EMPD has not been investigated. OBJECTIVES To examine the association between common genetic
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Morgellons disease shows a lower quality of life than psoriasis, atopic dermatitis, and prurigo nodularis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-21 Mackenzie O Gipple,Ramneek K Dhami,Emile Latour,Jesse J Keller
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Uncovering molecular mechanisms for amelanotic/hypopigmented primary cutaneous melanoma. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-21 Richard A Sturm,Darren J Smit,David L Duffy,Catriona McLean,Richard A Scolyer,Grant A McArthur,Anthony T Papenfuss,Mitchell S Stark,H Peter Soyer,Victoria J Mar
BACKGROUND A portion of approximately 2-20% of cutaneous melanoma (CM) are diagnosed as amelanotic/hypopigmented melanoma (AHM) and represent a challenge for early diagnosis. OBJECTIVES Since the degree to which somatic mutations and copy number aberrations (CNA) in genes associated with skin-lightening or albinism may contribute to the loss of tumour pigmentation in AHM samples has not yet been addressed
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Examining racial and ethnic disparities in diagnosis and access to care in infantile atopic dermatitis in the United States: a retrospective cohort study. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-20 Sarah E Servattalab,Michelle Lee,Madeline Hlobik,Hannah Song,Jennifer Huang
BACKGROUND Atopic dermatitis (AD) is an inflammatory skin disorder that is common in children and associated with medical and psychosocial comorbidities. Previous studies have shown that there exist significant racial disparities in healthcare utilization in children with AD; however, literature on disparities in dermatology access is limited. OBJECTIVES The primary aim of this study was to identify
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The quality-of-life impact of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) on patients' lives: An interpretative descriptive qualitative study. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-20 Pauline O'Reilly,Sarah Walsh,Christopher B Bunker,Sheila Ryan,Pierre-André Natella,Audrey Colin,Jacqueline Simpson,Louise A Barry,Pauline Meskell,Roni Dodiuk-Gad,Alice Coffey,Raja Savarimalai,Donal G Fortune,Saskia Ingen-Housz-Oro
BACKGROUND Much has been documented about the physical sequelae of Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Whilst less documented, it is recognised that patients can have long lasting psychological sequelae. There is a lack of qualitative research on the quality of life (QoL) experiences of adults who have been diagnosed with SJS/TEN. OBJECTIVES To explore the experiences
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Management and outcomes of hidradenitis suppurativa in solid organ transplant recipients. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-18 Reese L Imhof,Christina Dai,Afsaneh Alavi,Olayemi Sokumbi
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The Atopic Dermatitis Patient Journey: Insights from a Qualitative Study. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-18 Fanny C Kpenou,Carle Paul,Julien Seneschal,Nicolas Andreu,Sébastien Barbarot,Marie Tauber,Pierre-André Natella,Jason Shourick,Khaled Ezzedine
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Disseminated Juvenile Xanthogranuloma Harboring a GAB2::BRAF fusion Successfully Treated with Trametinib: a Case Report. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-16 Kai-Ni Shen,He Lin,Long Chang,Xin-Xin Cao
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The New Kid on the Block: Scoping Reviews. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-16 Jo Leonardi-Bee,Gloria Sanclemente,Carsten Flohr,Laurence Le Cleach
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A retrospective review of isotretinoin treatment-related mental health and sexual function outcomes in a tertiary acne clinic. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-16 Kyriaki Stefania Mitsaki,Sumir Chawla,Eirini E Merika
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Prevalence of abdominal aortic aneurysm in patients with hidradenitis suppurativa in the Veterans Affairs Health Care System. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-16 Zachary Wendland,Katelyn Rypka,Claire Herzog,Lindsey Greenlund,Travis Fulk,Amy Gravely,Anders Westanmo,Amit Garg,Noah Goldfarb
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Recent progress of Stevens-Johnson syndrome/toxic epidermal necrolysis: Diagnosis criteria, pathogenesis and therapy. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Natsumi Hama,Shigeki Aoki,Chun-Bing Chen,Akito Hasegawa,Youichi Ogawa,Marc Vocanson,Hideo Asada,Chia-Yu Chu,Cheng-Che E Lan,Roni P Dodiuk-Gad,Toshiharu Fujiyama,Tyng-Shiuan Hsieh,Kousei Ito,Elina Jerschow,Yoshiko Mizukawa,Saeko Nakajima,Kazutoshi Nakamura,Jean-François Nicolas,Takashi K Satoh,Tatsuo Shiohara,Hayato Takahashi,Mikiko Tohyama,Takahiro Ueda,Katsuaki Ura,Hideaki Watanabe,Yukie Yamaguchi
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a severe spectrum of rare mucocutaneous reactions, primarily drug-induced and characterized by significant morbidity and mortality. These conditions manifest through extensive skin detachment, distinguishing them from other generalized skin eruptions. The rarity and severity of SJS/TEN underscore the importance of accurate
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Comment on 'Morphology: the mother of all biomarkers'. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Francesca Prignano,Elia Rosi
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Towards a roadmap for COSEB: the next steps in harmonization of outcomes for epidermolysis bullosa. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Eva W H Korte,Anna M G Pasmooij,Maria C Bolling,Sinéad Hickey,Sagair Hussain,Dimitra Kiritsi,Jan Kottner,Cecilia A C Prinsen,Angélique Sauvestre,Gaston Sendin,Phyllis I Spuls,Núria Tarrats,Verena Wally,Tobias Welponer,Martin Laimer,Peter C van den Akker,
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Applying a novel optical technique for residual cancer detection with accuracy evaluation: a cornerstone for field implementation. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Byung Ho Oh,Ki Hean Kim
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Confetti cure: reversing the genetic kaleidoscope of ichthyosis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Judith Fischer
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Sodium-glucose cotransporter-2 inhibitors in diabetes and inflammatory skin diseases. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Chin-Hsuan Shen,Yi-Sun Yang,Irene Tai-Lin Lee,Meng-Han Chiang,Steven T Chen,Kevin Sheng-Kai Ma
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Hidradenitis suppurativa, systemic inflammatory response syndrome and sepsis: a database study. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Edigin Ehizogie,Ibrahim Maghari,Serigne Lo,Joerg Albrecht
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Expanding the knowledge of tumour necrosis factor-α-induced gasdermin E-mediated pyroptosis in psoriasis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Helen Vaher
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Tuning up the chords of consensus research with the ACcurate COnsensus Reporting Document (ACCORD). Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Esther J van Zuuren
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Correction to: Breastfeeding decreases the risk of developing psoriasis through to early adulthood. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14
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Increased risk of depression and anxiety in individuals with Darier disease. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Philip Curman,William Jebril,Henrik Larsson,Etty Bachar-Wikström,Martin Cederlöf,Jakob D Wikström
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Increased incidence of co-trimoxazole-induced rash in patients on systemic corticosteroid treatment for toxicity associated with immune checkpoint inhibitors. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Daniel Yiu,Silvia Aguilar-Duran,Charlotte Edwards,Dharmisha Chauhan,Andrew Furness,Samra Turajlic,James Larkin,Louise Fearfield,Kara Heelan
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Ecological evidence for melanoma overdiagnosis in Denmark. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Catherine M Olsen
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Fibroblasts with high matrix metalloproteinase 2 expression regulate CD8+ T-cell residency and inflammation via CD100 in psoriasis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Canbin Dong,Jui-Ming Lin,Xiaonian Lu,Junhao Zhu,Lanmei Lin,Jinhua Xu,Juan Du
BACKGROUND Psoriasis is a T cell-mediated chronic inflammatory skin condition characterized by the interaction of T cells with various cell types, forming an inflammatory microenvironment that sustains psoriatic inflammation. Homeostasis of these tissue-resident T cells is supported by fibroblasts, the primary structural cells in the dermis. In psoriasis, there is increased expression of matrix metalloproteinase
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Treating epidermolytic ichthyosis and ichthyosis with confetti with epidermal autografts cultured from revertant skin. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Kana Tanahashi,Michihiro Kono,Takenori Yoshikawa,Yuika Suzuki,Masukazu Inoie,Yachiyo Kuwatsuka,Fumie Kinoshita,Takuya Takeichi,Masashi Akiyama
BACKGROUND No efficient treatment has yet been established for epidermolytic ichthyosis (EI), which is caused by pathogenic variants of KRT1 or KRT10. Patients with ichthyosis with confetti (IWC) have multiple normal-appearing spots, caused by the revertant somatic recombination of pathogenic variants that occurs at each spot independently. Additionally, some patients with EI have large areas of normal
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Mutational profiling of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder does not resemble nodal peripheral T-cell lymphomas with a follicular helper T-cell phenotype. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Marta Rodríguez,Marcos Rebollo-González,Jesús Frutos Díaz-Alejo,Rebeca Manso,Francisco Javier Díaz de la Pinta,Juan Torre-Castro,Socorro María Rodríguez-Pinilla
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'Feeling like a second-class citizen': exploring the impact, self-management and existing support for adults living with acne and/or post-inflammatory hyperpigmentation and scarring. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Carys Dale,Rachael M Hewitt,Catherine Purcell,Neesha Pandya,Chris Bundy
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Vitamin D status in patients with erythropoietic protoporphyria taking the systemic photoprotective agent afamelanotide. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Lesley E Rhodes
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Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Radu A Boitor,Sandeep Varma,Ashish Sharma,Sunita Odedra,Somaia Elsheikh,Karim Eldib,Anand Patel,Alexey Koloydenko,Sonia Gran,Koen De Winne,Senada Koljenovic,Hywel C Williams,Ioan Notingher
BACKGROUND Autofluorescence (AF)-Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The technology does not require tissue fixation, staining, labelling or sectioning, and provides quantitative diagnosis maps of the surgical margins in 30 min. OBJECTIVES To determine the accuracy of the AF-Raman
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Deceptive pigment changes in neoadjuvant sonidegib therapy for basal cell carcinoma. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Shenxi Zhang,Menglong Ran
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The interferon story continues: EORTC CLTG study explores pegylated interferon α-2a's role in treating mycosis fungoides/Sézary syndrome. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Rudolf Stadler
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Concomitant moderate-to-severe cutaneous lesions have marked impact on quality of life in patients with active systemic lupus erythematosus: a cross-sectional insight from two phase III randomized clinical trials in adults. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Mischa J Mallbris,Bochao Jia,Youna Zhao,J Michelle Kahlenberg,Johann E Gudjonsson
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Long-term consequences on stigmatization and disease burden during adulthood among patients with childhood or adolescence-onset atopic dermatitis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Bruno Halioua,Charbel Skayem,Stéphanie Merhand,Yaron Ben Hayoun,Charles Taieb
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De novo autoimmune connective tissue disease and mortality in patients treated with anti-programmed death receptor-1 and anti-programmed death-ligand 1 therapy: a population-level cohort study. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Kimberly Tang,Ahmad Rajeh,Katharina S Shaw,Nga Nguyen,Guihong Wan,Kimberly B Hashemi,Rochelle L Castillo,Shawn G Kwatra,Nicole R LeBoeuf,Ruth Ann Vleugels,Yevgeniy R Semenov
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The pleiotropic role of interleukin-13 in the pathogenesis of atopic dermatitis. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Coco Dekkers,Marjolein de Bruin-Weller
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Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Yingfei Li,Yi He,Fangyuan Yang,Rongmei Liang,Wenchao Xu,Yehao Li,Jingbo Cheng,Baozhu Liang,Ming Tang,Xingliang Shi,Jian Zhuang,Minshuang Luo,Liuying Li,Ruilin Zhang,Huijuan Liu,Hongyu Jie,Xing Li,Xinai Han,Erwei Sun,Zeqing Zhai
BACKGROUND Psoriasis is a common chronic inflammatory disease with an unclear aetiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce inflammatory cell death. OBJECTIVES To investigate whether gasdermin E (GSDME)-mediated pyroptosis in keratinocytes contributes to the pathogenesis of psoriasis. METHODS Skin samples from patients with psoriasis and from healthy controls
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Increasing melanoma incidence with unchanged mortality: more sunshine, better treatment, increased diagnostic activity, overdiagnosis or lowered diagnostic threshold? Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Jesper Bo Nielsen,Ivar Sønbø Kristiansen,Subash Thapa
BACKGROUND Increasing melanoma incidence with less increasing mortality is observed in several countries. This discrepancy is not well understood. OBJECTIVES In this study, our aim was to discuss factors [ultraviolet radiation (UVR) exposure, melanoma treatment, diagnostic activity, overdiagnosis, pathologists' diagnostic threshold and clinicians' propensity to remove suspect skin lesions] that might
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Filling the prescription gap: the value of community support in psoriasis management. Br. J. Dermatol. (IF 11.0) Pub Date : 2024-08-14 Melissa C Leeolou,Kavita Y Sarin,David F Fiorentino