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Jingle Cell Rock: Steering Cellular Activity With Low-Intensity Pulsed Ultrasound (LIPUS) to Engineer Functional Tissues in Regenerative Medicine. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-16 Martina Marcotulli,Andrea Barbetta,Edoardo Scarpa,Fabiano Bini,Franco Marinozzi,Giancarlo Ruocco,Carlo Massimo Casciola,Chiara Scognamiglio,Dario Carugo,Gianluca Cidonio
Acoustic manipulation or perturbation of biological soft matter has emerged as a promising clinical treatment for a number of applications within regenerative medicine, ranging from bone fracture repair to neuromodulation. The potential of ultrasound (US) endures in imparting mechanical stimuli that are able to trigger a cascade of molecular signals within unscathed cells. Particularly, low-intensity
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Sonoanatomy of the Finger Synovio-Entheseal Complexes. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-16 Esperanza Naredo,Jacqueline Uson,Otto Olivas-Vergara,Carlos Guillén-Astete,Pablo González Del Pozo,José Ramón Mérida-Velasco,Jorge Murillo-González
OBJECTIVES The objectives of this ultrasound and anatomical study were: (1) To evaluate the reliability of ultrasound identification of the enthesis of the central slip of the extensor digitorum tendon (CSET) using cadaver specimens; (2) To assess the concordance of the measurement of the CSET thickness by ultrasound and gross anatomy; (3) To evaluate the variation in ultrasound identification of the
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A Nomogram Based on Features of Ultrasonography and Contrast-Enhanced CT to Predict Vessels Encapsulating Tumor Clusters Pattern of Hepatocellular Carcinoma. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-16 Litao Ruan,Jingtong Yu,Xingqi Lu,Kazushi Numata,Dong Zhang,Xi Liu,Xiaojing Li,Mingwei Zhang,Feiqian Wang
OBJECTIVE This study aimed to establish a clinical prediction model for vessels encapsulating tumor clusters (VETC) based on preoperative ultrasonography (US) and contrast-enhanced computed tomography (CECT) imaging in patients with hepatocellular carcinoma (HCC). METHODS Data were retrospectively collected from 215 patients who underwent hepatectomy for solitary HCC lesions. They were divided into
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Automated Field of Interest Determination for Quantitative Ultrasound Analyses of Cervical Tissues: Toward Real-time Clinical Translation in Spontaneous Preterm Birth Risk Assessment. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-12 Jingyi Zuo,Douglas G Simpson,William D O'Brien,Barbara L McFarlin,Aiguo Han
OBJECTIVE Quantitative ultrasound (QUS) analysis of the human cervix is valuable for predicting spontaneous preterm birth risk. However, this approach currently requires an offline processing step wherein a medically trained analyst manually draws a free-hand field of interest (Manual FOI) for QUS computation. This offline step hinders the clinical adoption of QUS. To address this challenge, we developed
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A Study on the Effects of Depth-Dependent Power Loss on Speckle Statistics Estimation. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-07 Alexandra Christensen,Ivan Rosado-Mendez,Timothy J Hall
Characterization of the interference patterns observed in B-mode images (i.e., speckle statistics) is a valuable tool in tissue characterization. However, changes in echo amplitudes unrelated to speckle, including power loss due to attenuation and diffraction, can bias these metrics, undermining their utility. Tissue with high attenuation such as the uterine cervix are especially affected. The purpose
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High-Frame-Rate Ultrasound Velocimetry in the Healthy Femoral Bifurcation: A Comparative Study Against 4-D Flow Magnetic Resonance Imaging. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-06 Majorie van Helvert,Janna Ruisch,Joosje M K de Bakker,Anne E C M Saris,Chris L de Korte,Michel Versluis,Erik Groot Jebbink,Michel M P J Reijnen
OBJECTIVE Local flow dynamics impact atherosclerosis yet are difficult to quantify with conventional ultrasound techniques. This study investigates the performance of ultrasound vector flow imaging (US-VFI) with and without ultrasound contrast agents in the healthy femoral bifurcation. METHODS High-frame-rate ultrasound data with incremental acoustic outputs were acquired in the femoral bifurcations
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Deep Learning Based Shear Wave Detection and Segmentation Tool for Use in Point-of-Care for Chronic Liver Disease Assessments. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-06 Mohammad Honarvar,Julio Lobo,Caitlin Schneider,Nathan Wolfe,Samer Gawrieh,Rohit Loomba,Alnoor Ramji,Tarek Hassanein,Eric M Yoshida,Emily Pang,Michael P Curry,Nezam H Afdhal
OBJECTIVE As metabolic dysfunction-associated steatotic liver disease (MASLD) becomes more prevalent worldwide, it is imperative to create more accurate technologies that make it easy to assess the liver in a point-of-care setting. The aim of this study is to test the performance of a new software tool implemented in Velacur (Sonic Incytes), a liver stiffness and ultrasound attenuation measurement
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Effect of Respirophasic Displacement of the Inferior Vena Cava on Size Measurement in 2-D Ultrasound Imaging. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-05 Piero Policastro,Leonardo Ermini,Stefania Civera,Stefano Albani,Giuseppe Musumeci,Silvestro Roatta,Luca Mesin
OBJECTIVE Volume status assessment of a patient by ultrasound (US) imaging of the inferior vena cava (IVC) is important for the diagnosis and prognosis of various clinical conditions. In order to improve the clinical investigation of IVC, which is mainly based on unidirectional US (in M-mode), automated processing of 2-D US scans (in B-mode) has enabled tissue movement tracking on the visualized plane
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Trajectory of Postpartum Cervical Remodeling in Women Delivering Full-Term and Spontaneous Preterm: Sensitivity to Quantitative Ultrasound Biomarkers. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-04 Michelle Villegas-Downs,Mehrdad Mohammadi,Aiguo Han,William D O'Brien,Douglas G Simpson,Tara A Peters,Judith M Schlaeger,Barbara L McFarlin
OBJECTIVE Women with a history of spontaneous preterm birth (sPTB) face an increased risk of recurrence. Yet, the factors contributing to the increased risk are unknown, hampering the development of targeted interventions. Noninvasive quantitative ultrasound (QUS) has been validated in the characterization of cervical tissue and has the potential to provide information about postpartum cervical remodeling
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Characterization of Indeterminate Breast Lesions Based on Pressure Estimates by Noninvasive 3D Contrast-Enhanced Ultrasound. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-09-04 Kibo Nam,Mehnoosh Torkzaban,Jason P Shames,Lydia Liao,Corinne E Wessner,Priscilla Machado,Andrej Lyshchik,Flemming Forsberg
OBJECTIVE To assess the ability of the pressure gradient between breast lesions and adjacent normal tissue estimated by 3D subharmonic-aided pressure estimation (SHAPE) to characterize indeterminate breast lesions. METHODS This prospective study enrolled patients scheduled for ultrasound-guided needle biopsies of a breast lesion. Before the biopsy, 3D SHAPE data were collected from the breast lesion
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Identification and Quantification of Precursory Changes of Rheumatoid Vasculitis in the Dorsalis Pedis Artery. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-31 Bo-Wen Ren,Robyn Boman,Rosa H M Chan,Roy T H Cheung,Stefania Penkala,Fredrick Joshua,Bernard Chiu
OBJECTIVE Rheumatoid arthritis (RA) is a systemic connective tissue autoimmune disease that can infiltrate arterial walls. The delay in diagnosis and treatment of rheumatoid vasculitis (RV) in patients with RA may lead to irreversible damage to the arterial walls of small-to-medium vessels, which has serious and devastating consequences, most notably lung and cardiac damage. In this work an ultrasound
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Ultrasound-Guided Blockade of the Lateral Cutaneous Branch of the Iliohypogastric Nerve to Differentiate Neuropathy From Greater Trochanteric Pain Syndrome: Cadaver Study and Initial Case Series. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-31 Paata Pruidze,Tobias Rossmann,Karoline M Schwendt,Anton Liederer,Helmut Rauschka,Wolfgang J Weninger,Stefan Meng
OBJECTIVE Neuropathy of the lateral cutaneous branch of the iliohypogastric nerve (LCBIN) may represent a differential diagnosis for greater trochanteric pain syndrome (GTPS). Ultrasound-guided neural blockade of the LCBIN may lead to diagnosis of this neuropathy. The aim of this study was to evaluate the accuracy of ultrasound-guided nerve block in cadavers and to present a first clinical case series
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Investigation Into the Subharmonic Response of Three Contrast Agents in Static and Dynamic Flow Environments Using a Commercially Available Diagnostic Ultrasound Scanner. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-30 Hailee Mayer,Ga Won Kim,Priscilla Machado,John R Eisenbrey,Trang Vu,Kirk Wallace,Flemming Forsberg
OBJECTIVE The objective of this study was to investigate the subharmonic response of Lumason (also known as SonoVue; Bracco, Milan, Italy) to static and dynamic ambient pressures, with a direct comparison to Sonazoid (GE HealthCare, Oslo, Norway) and Definity (Lantheus Medical Imaging, MA, USA). The subharmonic responses of contrast agents can be exploited to perform subharmonic-aided pressure estimation
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Contrast-Enhanced Ultrasound Reveals Superior Gluteus Medius Muscle Vitality After Total Hip Arthroplasty in a Minimally Invasive Anterolateral Versus Lateral Surgical Approach. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-28 Mick Paul,Schaible Robin,Renkawitz Tobias,Walker Tilman,Innmann Moritz,Tsitlakidis Stefanos,Hariri Mustafa,Doll Julian
OBJECTIVE Total hip arthroplasty (THA) is essential for treating severe osteoarthritis. With various surgical approaches available, there has been a shift toward techniques that offer quicker recovery and fewer complications. In this study, contrast-enhanced ultrasound was used to evaluate the impact of the minimally invasive anterolateral versus conventional lateral approach in THA on the gluteus
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Study on the Effects of Low-Intensity Pulsed Ultrasound and Iron Ions for Proliferation and Differentiation of Osteoblasts. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-28 Huanbin Xiong,Mengshu Cao,Yanan Yu,Xueyou Duan,Lijun Sun,Liang Tang,Xiushan Fan
OBJECTIVE This study involved the proliferation and differentiation of osteoblasts treated with low-intensity pulsed ultrasound (LIPUS) and iron (Fe3+) ions, respectively. The biological effects of LIPUS and Fe3+ ions on the proliferation and differentiation of osteoblasts were also evaluated. METHODS MC3T3-E1 cells were seeded in six-well plates with the medium, which contained different concentrations
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CEUS LI-RADS in Combination With the Serum Biomarker-Based ASAP Model Improves the Diagnostic Performance of HCC in High-Risk Patients. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-23 Rong Wen,Yuting Peng,Yiqiong Liang,Yuquan Wu,Haiyuan Li,Yanxia Chen,Yan Qin,Zhiyuan Wen,Huanyu Cui,Yun He,Hong Yang
OBJECTIVE To assess the diagnostic efficacy of the CEUS LI-RADS combined with a model constructed on the basis of age, sex, AFP, and PIVKA-II (ASAP) for the diagnosis of HCC in high-risk patients. METHODS This retrospective study included 366 liver lesions from 366 patients who underwent liver CEUS. All liver lesions were characterized and categorized according to CEUS LI-RADS v2017. Two modified methods
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Cross-modal Transfer Learning Based on an Improved CycleGAN Model for Accurate Kidney Segmentation in Ultrasound Images. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-23 Shuaizi Guo,Haijie Chen,Xiangyu Sheng,Yinzheng Xiong,Menglin Wu,Katherine Fischer,Gregory E Tasian,Yong Fan,Shi Yin
OBJECTIVE Deep-learning algorithms have been widely applied in the field of automatic kidney ultrasound (US) image segmentation. However, obtaining a large number of accurate kidney labels clinically is very difficult and time-consuming. To solve this problem, we have proposed an efficient cross-modal transfer learning method to improve the performance of the segmentation network on a limited labeled
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Feasibility and Safety of Integrating Extended TCD Assessments in a Full Multimodal Neuromonitoring Protocol After Traumatic Brain Injury. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-22 Stefan Yu Bögli,Giada Cucciolini,Marina Sandra Cherchi,Virginia Motroni,Ihsane Olakorede,Ronan O'Leary,Erta Beqiri,Claudia Ann Smith,Peter Smielewski
OBJECTIVE Targeting single monitoring modalities such as intracranial pressure (ICP) or cerebral perfusion pressure alone has shown to be insufficient in improving outcome after traumatic brain injury (TBI). Multimodality monitoring (MMM) allows for a more complete description of brain function and for individualized management. Transcranial Doppler (TCD) represents the gold standard for continuous
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Deep Learning With Ultrasound Images Enhance the Diagnosis of Nonalcoholic Fatty Liver. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-22 Yao Liu,Wenrou Yu,Peizheng Wang,Yingzhou Huang,Jin Li,Pan Li
OBJECTIVE This research aimed to improve diagnosis of non-alcoholic fatty liver disease (NAFLD) by deep learning with ultrasound Images and reduce the impact of the professional competence and personal bias of the diagnostician. METHOD Three convolutional neural network models were used to classify and identify the ultrasound images to obtain the best network. Then, the features in the ultrasound images
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Multiparametric Ultrasound Imaging of Prostate Cancer Using Deep Neural Networks. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-21 Derek Y Chan,D Cody Morris,Spencer R Moavenzadeh,Theresa H Lye,Thomas J Polascik,Mark L Palmeri,Jonathan Mamou,Kathryn R Nightingale
OBJECTIVE A deep neural network (DNN) was trained to generate a multiparametric ultrasound (mpUS) volume from four input ultrasound-based modalities (acoustic radiation force impulse [ARFI] imaging, shear wave elasticity imaging [SWEI], quantitative ultrasound-midband fit [QUS-MF], and B-mode) for the detection of prostate cancer. METHODS A DNN was trained using co-registered ARFI, SWEI, MF, and B-mode
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A Shape-Consistent Deep-Learning Segmentation Architecture for Low-Quality and High-Interference Myocardial Contrast Echocardiography. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-14 Rongpu Cui,Shichu Liang,Weixin Zhao,Zhiyue Liu,Zhicheng Lin,Wenfeng He,Yujun He,Chaohui Du,Jian Peng,He Huang
OBJECTIVE Myocardial contrast echocardiography (MCE) plays a crucial role in diagnosing ischemia, infarction, masses and other cardiac conditions. In the realm of MCE image analysis, accurate and consistent myocardial segmentation results are essential for enabling automated analysis of various heart diseases. However, current manual diagnostic methods in MCE suffer from poor repeatability and limited
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Use of High-Frequency Ultrasound for the Correlation of Epithelial Rete Peg Variation. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-13 Ankita Samal,Hsun-Liang Chan,I-Ching Wang,Liana Webber,Sarah Gallagher,Jad Majzoub,Shayan Barootchi,John Mazzocco,Amanda Rodriguez Betancourt,Rogerio Castilho,Maria Masotti,Oliver D Kripfgans
OBJECTIVE Rete pegs are projections of the oral epithelium into connective tissue. Their dimensions change during pathological conditions and may correlate with wound-healing status. Non-invasive, high-frequency ultrasound (US) may be able to capture these changes and aid in early detection of histopathological changes. The aim of this preclinical study is to correlate US images with histology and
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Harnessing Large Language Models for Structured Reporting in Breast Ultrasound: A Comparative Study of Open AI (GPT-4.0) and Microsoft Bing (GPT-4). Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-12 ChaoXu Liu,MinYan Wei,Yu Qin,MeiXiang Zhang,Huan Jiang,JiaLe Xu,YuNing Zhang,Qing Hua,YiQing Hou,YiJie Dong,ShuJun Xia,Ning Li,JianQiao Zhou
OBJECTIVES To assess the capabilities of large language models (LLMs), including Open AI (GPT-4.0) and Microsoft Bing (GPT-4), in generating structured reports, the Breast Imaging Reporting and Data System (BI-RADS) categories, and management recommendations from free-text breast ultrasound reports. MATERIALS AND METHODS In this retrospective study, 100 free-text breast ultrasound reports from patients
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Automated Method for Growing Rod Length Measurement on Ultrasound Images in Children With Early Onset Scoliosis. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-09 Mohammad Humayun Kabir,Marek Reformat,Sarah Southon Hryniuk,Kyle Stampe,Edmond Lou
OBJECTIVE To develop and validate machine learning algorithms to automatically extract the rod length of the magnetically controlled growing rod from ultrasound images (US) in a pilot study. METHODS Two machine-learning (ML) models, called the "Boundary model" and "Rod model," were developed to identify specific rod segments on ultrasound images. The models were developed utilizing Mask Regional Convolutional
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EasyPISA: Automatic Integrated PISA Measurements of Mitral Regurgitation From 2-D Color-Doppler Using Deep Learning. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-08 Sigurd Vangen Wifstad,Henrik Agerup Kildahl,Espen Holte,Erik Andreas Rye Berg,Bjørnar Grenne,Øyvind Salvesen,Håvard Dalen,Lasse Lovstakken
OBJECTIVE The proximal isovelocity surface area (PISA) method is a well-established approach for mitral regurgitation (MR) quantification. However, it exhibits high inter-observer variability and inaccuracies in cases of non-hemispherical flow convergence and non-holosystolic MR. To address this, we present EasyPISA, a framework for automated integrated PISA measurements taken directly from 2-D color-Doppler
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Biomodulatory Effects of Molecular Delivery in Human T Cells Using 3D-Printed Acoustofluidic Devices. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-05 Connor S Centner,Clinton J Belott,Riyakumari K Patel,Michael A Menze,Kavitha Yaddanapudi,Jonathan A Kopechek
OBJECTIVE Cell-based therapies have shown significant promise for treating many diseases, including cancer. Current cell therapy manufacturing processes primarily utilize viral transduction to insert genomic material into cells, which has limitations, including variable transduction efficiency and extended processing times. Non-viral transfection techniques are also limited by high variability or reduced
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Reliability and Accuracy of Ultrasound Measurement of Hip Displacement in Children with Cerebral Palsy. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-03 Thanh-Tu Pham,Lawrence H Le,John Andersen,Edmond Lou
OBJECTIVE Hip migration percentage (MP) measured on anteroposterior pelvis radiographs is the gold standard to assess the severity of hip displacement in children with cerebral palsy (CP). Repeated exposure of these children to ionizing radiation under a hip surveillance program is undesirable. Recently, a semi-automatic approach to measure MPUS on ultrasound (US) images was validated in a phantom
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Ultrasonographic Predictors for Post-operative Ischemic Events After Indirect Revascularization Surgeries in Patients with Moyamoya Disease. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-03 Shin-Joe Yeh,Sung-Chun Tang,Li-Kai Tsai,Tzu-Ching Chen,Pei-Lin Li,Ya-Fang Chen,Meng-Fai Kuo,Jiann-Shing Jeng
OBJECTIVE Recurrent stroke after revascularization surgeries predicts poor outcome in patients with moyamoya disease (MMD). Early identification of patients with stroke risk paves the way for rescue intervention. This study aimed to investigate the role of ultrasound in identifying patients at risk of post-operative ischemic events (PIEs). METHODS This prospective study enrolled patients with symptomatic
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Ultrasound-Based Radiomics for Predicting the WHO/ISUP Grading of Clear-Cell Renal Cell Carcinoma. Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-08-02 Yue-Fan Chen,Fen Fu,Jia-Jing Zhuang,Wen-Ting Zheng,Yi-Fan Zhu,Guang-Tian Lian,Xiao-Qing Fan,Hui-Ping Zhang,Qin Ye
OBJECTIVE To explore the performance of ultrasound image-based radiomics in predicting World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading of clear-cell renal cell carcinoma (ccRCC). METHODS A retrospective study was conducted via histopathological examination on participants with ccRCC from January 2021 to August 2023. Participants were randomly allocated to
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A Prediction Model for Assessing the Efficacy of Thermal Ablation in Treating Benign Thyroid Nodules ≥ 2 cm: A Multi-Center Retrospective Study Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-31 Meng-Yu Lu, Ying Zhou, Xiao-Wan Bo, Xiao-Long Li, Jun Luo, Chao-Nan Li, Cheng-Zhong Peng, Hui-Hui Chai, Wen-Wen Yue, Li-Ping Sun
To develop and validate a prediction model utilizing clinical and ultrasound (US) data for preoperative assessment of efficacy following US-guided thermal ablation (TA) in patients with benign thyroid nodules (BTNs) ≥ 2 cm. We retrospectively assessed 962 patients with 1011 BTNs who underwent TA at four tertiary centers between May 2018 and July 2022. Ablation efficacy was categorized into therapeutic
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Achilles Tendon Stiffness: Influence of Measurement Methodology Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-29 Ra'ad M. Khair, Maria Sukanen, Taija Finni
Mechanical stiffness derived from force-elongation curves is fundamentally different from shear wave (SW) elastography-based tissue properties. We compared these techniques, with a total of five methods of assessing Achilles tendon (AT) stiffness. Seventeen participants (12 male and 5 female) with unilateral AT rupture performed submaximal contractions at 30% and 10% maximal isometric contraction torque
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B-mode Ultrasound Related Combined Predictive Indicators for Benign Versus Malignant Subpleural Pulmonary Lesions Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-26 Mengjun Shen, Hongwei Chen, Jixin Shu, Wei Yang, Kun Zhao, Qing Tang, Xinghua Zhou, Yin Wang
The purpose of this study was to analyze the independent risk factors of malignant subpleural pulmonary lesions (SPLs) on B-mode ultrasound (US) images, to construct the combined predictive indicators, and to prospectively verify their predictive efficacy. A total of 336 patients with SPLs were included in the prospective study, of whom the single-center included patients between September 2019 and
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Investigation of Ultrasound Mediated Extravasation of a Model Drug by Perfluorobutane Nanodroplets Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-26 Qiang Wu, Victor Choi, Luca Bau, Dario Carugo, Nicholas D. Evans, Eleanor Stride
Perfluorocarbon nanodroplets (NDs) have been widely investigated as both diagnostic and therapeutic agents. There remains, however, a challenge in generating NDs that do not vaporize spontaneously but can be activated at ultrasound pressures that do not produce unwanted bioeffects. In previous work, it has been shown that phospholipid-coated perfluorobutane (PFB) NDs can potentially overcome this challenge
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A Comparative Study of Commercially Available Ultrasound Contrast Agents for Sub-harmonic-Aided Pressure Estimation (SHAPE) in a Bladder Phantom Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-25 Kourosh Kalayeh, J. Brian Fowlkes, Sophia Yeras, Amy Chen, Stephanie Daignault-Newton, William W. Schultz, Bryan S. Sack
The goal of this study was to evaluate the performance of different commercial ultrasound contrast microbubbles (MBs) when measuring bladder phantom pressure with sub-harmonic-aided pressure estimation (SHAPE) methodology. We hypothesized that SHAPE performance is dependent on MB formulation. This study aimed to advance the SHAPE application for bladder pressure measurements in humans. Using a previously
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Corrigendum to ‘Material Properties, Dissolution and Time Evolution of PEGylated Lipid-Shelled Microbubbles: Effects of the Polyethylene Glycol Hydrophilic Chain Configurations’ Journal of Ultrasound in Medicine and Biology, Volume 48, Issue 9, Pages 1720-1732 Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-25 Roozbeh H. Azami, Mitra Aliabouzar, Jenna Osborn, Krishna N. Kumar, Flemming Forsberg, John R. Eisenbrey, Sanku Mallik, Kausik Sarkar
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Development and Validation of an Explainable Machine Learning Model for Identification of Hyper-Functioning Parathyroid Glands from High-Frequency Ultrasonographic Images Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-25 Wenwen Zhou, Yu Zhou, Xiaoer Zhang, Tongyi Huang, Rui Zhang, Di Li, Xiaoyan Xie, Yi Wang, Ming Xu
To develop and validate a machine learning (ML) model based on high-frequency ultrasound (HFUS) images with the aim to identify the functional status of parathyroid glands (PTGs) in secondary hyper-parathyroidism (SHPT) patients. This retrospective study enrolled 60 SHPT patients (27 female, 33 male; mean age: 51.2 years) with 184 PTGs detected from February 2016 to June 2022. All enrollments underwent
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Differential Diagnosis of Pathological Type of Peripheral Lung Cancer with Multimodal Contrast-Enhanced Ultrasound Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-23 Du Yu Qing, Bai Jing, Wang Bing, Wang Song, Zhang Qi Fei, Yan Kun, Yang Wei
The goal of the work described here was to investigate the role of multimodal contrast-enhanced ultrasound in the differential diagnosis of peripheral lung cancer. From April 2017 to July 2021, 109 patients with confirmed pulmonary malignant lesions who underwent CEUS examination were involved in our study. Seven patients were excluded because of the short duration of CEUS video or unsatisfactory imaging
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A Low-Complexity Beamformer for Ultrasound Imaging Based on Sub-Beamformer and Multi-Apodization With Cross-Correlation Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-22 Yue Shen, Ping Wang, Lin Tong, Jinghan Chen, Qianwen Li, Jinchan Zhu, Kunlin Wang, Jingya Zeng
This paper proposes an ultrasound imaging algorithm based on sub-beamformer and multi-apodization with cross-correlation (SUB-MAX), aiming to achieve high resolution close to the minimum variance (MV) beamforming with low complexity and to enhance image contrast while maintaining background quality. The output of two (/2)-element DAS beamformers with asymmetric phase centers is subtracted, resulting
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Influencing Factors, Reference Range and Repeatability of Salivary Gland Ultrasound Viscoelastic Imaging in Healthy Adults Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-18 Jinjin Li, Han Yuan, Yong Gao
The study aimed to determine the influencing factors, reference range, the changes of salivary gland secretion function and repeatability of measurements taken from ultrasound (US) viscoelastic imaging in the salivary glands of healthy adults. From August 2023 to October 2023, 206 healthy adults were recruited. In November 2023, 50 healthy adults were recruited for acid stimulation testing. All volunteers
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High-Intensity Focused Ultrasound Ablation Combined With Pharmacogenomic-Guided Chemotherapy for Advanced Pancreatic Cancer: Initial Experience Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-18 Lifeng Ran, Wei Yang, Xing Chen, Jun Zhang, Kun Zhou, Hui Zhu, Chengbing Jin
To investigate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation combined with pharmacogenomic-guided chemotherapy in treating patients with advanced pancreatic cancer (PC). Thirty-one patients with unresectable PC (stage III 17, stage IV 14) were enrolled in this study. The patients were divided into group A (pharmacogenomic-guided chemotherapy following HIFU treatment,
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Removing Artifacts in Transcranial Photoacoustic Imaging With Polarized Self-Attention Dense-UNet Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-15 Boyi Li, Mengyang Lu, Tianhua Zhou, Mengxu Bu, Wenting Gu, Junyi Wang, Qiuchen Zhu, Xin Liu, Dean Ta
Photoacoustic imaging (PAI) is a promising transcranial imaging technique. However, the distortion of photoacoustic signals induced by the skull significantly influences its imaging quality. We aimed to use deep learning for removing artifacts in PAI. In this study, we propose a polarized self-attention dense U-Net, termed PSAD-UNet, to correct the distortion and accurately recover imaged objects beneath
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Reconstructing Cancellous Bone From Down-Sampled Optical-Resolution Photoacoustic Microscopy Images With Deep Learning Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-07 Jingxian Wang, Boyi Li, Tianhua Zhou, Chengcheng Liu, Mengyang Lu, Wenting Gu, Xin Liu, Dean Ta
Bone diseases deteriorate the microstructure of bone tissue. Optical-resolution photoacoustic microscopy (OR-PAM) enables high spatial resolution of imaging bone tissues. However, the spatiotemporal trade-off limits the application of OR-PAM. The purpose of this study was to improve the quality of OR-PAM images without sacrificing temporal resolution. In this study, we proposed the Photoacoustic Dense
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Dynamic Ultrasound Localization Microscopy Without ECG-Gating Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-04 Nin Ghigo, Gerardo Ramos-Palacios, Chloé Bourquin, Paul Xing, Alice Wu, Nelson Cortés, Hugo Ladret, Lamyae Ikan, Christian Casanova, Jonathan Porée, Abbas Sadikot, Jean Provost
Dynamic Ultrasound Localization Microscopy (DULM) has first been developed for non-invasive Pulsatility measurements in the rodent brain. DULM relies on the localization and tracking of microbubbles (MBs) injected into the bloodstream, to obtain highly resolved velocity and density cine-loops. Previous DULM techniques required ECG-gating, limiting its application to specific datasets, and increasing
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Establishment and Validation of a Predictive Model for Sarcopenia Based on 2-D Ultrasound and Shear Wave Elastography in the Medial Gastrocnemius Muscle Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-04 Zecheng Wang, Zhenhong Xu, Huohu Zhong, Xinying Zheng, Lisheng Yan, Guorong Lyu
To develop and validate a predictive model for sarcopenia. A total of 240 subjects who visited our hospital between August 2021 and May 2023 were randomly divided by time of entry into a training set containing 2/3 of patients and a validation set containing 1/3 of patients. The muscle thickness (MT), echo intensity (EI), and shear wave velocity (SWV) of the medial gastrocnemius muscle were measured
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From Benign Lipoma to G3 Liposarcoma: Contrast-Enhanced Ultrasound Reveals Tumor Microperfusion and Indicates Malignancy Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-07-02 Paul Mick, Marie Rohner, Tobias Renkawitz, Burkhard Lehner, Andreas Geisbüsch, Stefanos Tsitlakidis, Mustafa Hariri, Julian Deisenhofer, Michelle Müller, Julian Doll
Lipomatous soft tissue tumors (STT), ranging from benign lipomas to malignant liposarcomas, require accurate differentiation for timely treatment. Complementary to MRI, Contrast-enhanced ultrasound (CEUS) is emerging as a promising tool, providing insight into tumor microperfusion in real-time. This study aims to explore the potential of preoperative CEUS in differentiating benign lipomatous tumors
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DF-GAM: Cross-Domain Ultrasound Image High-Quality Reconstruction Using a Dual Frequency-Domain Guided Adaptation Model Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-27 Fei Dai, Wenyu Xing, Yunkai Zhu, Boyi Li, Yaqing Chen, Dean Ta
To enhance the quality of low-resolution (LR) ultrasound images and mitigate artifacts and speckle noise, which can impede accurate medical diagnosis, a novel method called the dual frequency-domain guided adaptation model (DF-GAM) is proposed. The method aims to achieve high-quality image reconstruction across diverse domains, including different ultrasound machines, diseases and phantom images. DF-GAM
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Neural Network Classification Algorithm Based on Self-attention Mechanism and Ensemble Learning for MASLD Ultrasound Images Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-22 Lijuan Guo, Liling Shi, Wenjuan Wang, Xiaotong Wang
Ultrasound image examination has become the preferred choice for diagnosing metabolic dysfunction-associated steatotic liver disease (MASLD) due to its non-invasive nature. Computer-aided diagnosis (CAD) technology can assist doctors in avoiding deviations in the detection and classification of MASLD. We propose a hybrid model that integrates the pre-trained VGG16 network with an attention mechanism
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Enhancing Breast Cancer Diagnosis: A Nomogram Model Integrating AI Ultrasound and Clinical Factors Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-19 Zi-Han Yu, Yu-Ting Hong, Chen-Pin Chou
A novel nomogram incorporating artificial intelligence (AI) and clinical features for enhanced ultrasound prediction of benign and malignant breast masses. This study analyzed 340 breast masses identified through ultrasound in 308 patients. The masses were divided into training (n = 260) and validation (n = 80) groups. The AI-based analysis employed the Samsung Ultrasound AI system (S-detect). Univariate
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The Impact of HIFU Ablation on the Histopathological Features of Locally Recurrent Fibroids Tissue Post-HIFU Treatment Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-18 Pingping Zhang, Lingling Xie, Jinyun Chen, Ping Zhan, H.Rosie Xing, Yuan Yuan
To evaluate the impact of high-intensity focused ultrasound (HIFU) ablation on the histopathological features of locally recurrent fibroids tissue. Patients who underwent transabdominal hysterectomy or myomectomy for uterine fibroids from January 1, 2021 to July 1, 2023 at a teaching hospital in China were enrolled in this prospective study. The patients who underwent surgery for local recurrence of
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Ultrasound Therapy With High-Pressure Pulses Is Effective to Reduce the Effects of Collagenase-Induced Tendinopathy in Rat's Achilles Tendon Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-14 Carlos M. Martínez, Pedro LLontop, Fernando Pérez-Sanz, Fernando Asensio, Francisco Montero de Espinosa
We propose an ultrasonic treatment for collagenase-induced tendinopathy in rat's Achilles tendon using pulses with a low number of cycles, high acoustic pressure and very low duty cycle. Twenty rats were used to perform the experiment. Four experimental groups of calcaneal tendons were studied: control (n = 6), sham (n = 4), collagenase-induced tendinopathy (n = 8) and ultrasound-treated collagenase-induced
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Differentiating Benign From Malignant Ovarian Masses With Solid Components: Diagnostic Performance of CEUS Combined With IOTA Simple Rules and O-RADS Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-13 Beilei Lu, Wanyuan He, Chang Liu, Pan Wang, Ping Yang, Zhengyong Zhao, Jiuling Qi, Beijian Huang
This study aimed to apply the International Ovarian Tumor Analysis (IOTA) Simple Rules (SR), the Ovarian-Adnexal Reporting and Data System (O-RADS) and contrast-enhanced ultrasound (CEUS) in an identical cohort of Chinese patients and to analyze their performance in discrimination of ovarian masses with solid components. This was a two-center retrospective study that included a total of 94 ovarian
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Volumetric Ultrasound Imaging for the Whole Soft Tissue: Toward Enhanced Thyroid Disease Examination Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-13 Xu Cheng, Enxiang Shen, Yunye Cai, Kai Fan, Li Gong, Jie Wu, Han Liu, Yuxin Wang, Ying Chen, Yun Ge, Jie Yuan, Wentao Kong
Ultrasound imaging (USI) is the gold standard in the clinical diagnosis of thyroid diseases. Compared with two-dimensional (2D) USI, three-dimensional (3D) USI could provide more structural information. However, the unstable pressure generated by the hand-hold ultrasound probe scanning can cause tissue deformation, especially in soft tissues such as the thyroid. The deformation is manifested as tissue
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Influence of Phase Change Droplet Activation and Microbubble Cavitation on the Microenvironment of Hepatocellular Carcinoma Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-13 Hebah A. Falatah, Quezia Lacerda, Corinne E. Wessner, Standley Lo, Margaret A. Wheatley, Ji-Bin Liu, John R. Eisenbrey
Both microbubble ultrasound contrast agents and acoustic phase change droplets (APCD) have been explored in hepatocellular carcinoma (HCC). This work aimed to evaluate changes to the HCC microenvironment following either microbubble or APCD destruction in a syngeneic pre-clinical model. Mouse RIL-175 HCC tumors were grown in the right flank of 64 immunocompetent mice. Pre-treatment, photoacoustic volumetric
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Associations Between Multiparametric US-Based Indicators and Pathological Status in Patients with Metabolic Associated Fatty Liver Disease Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-12 Yan Zhou, Mengjin Nie, Feng Mao, Hongyu Zhou, Lin Zhao, Jianmin Ding, Yanmin Kan, Xiang Jing
Noninvasive evaluation of metabolic dysfunction-associated fatty liver disease (MAFLD) using ultrasonography holds significant clinical value. The associations between ultrasound (US)-based parameters and the pathological spectra remain unclear and controversial. This study aims to investigate the associations thoroughly. The participants with MAFLD undergoing liver biopsy and multiparametric ultrasonography
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Anterior Chamber Depth and Lens Thickness Measurements in Pediatric Eyes: Ultrasound Biomicroscopy Versus Immersion A-Scan Ultrasonography Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-12 Taylor Kolosky, Urjita Das, Bhakti Panchal, Sarah Byun, Alexandra Dolgetta, Moran R. Levin, Janet L. Alexander
To compare anterior chamber depth (ACD) and lens thickness (LT) measurements by ultrasound biomicroscopy (UBM), A-scan cross vector (CV) overlay with UBM, and immersion A-scan technique in pediatric eyes. This prospective comparative cohort study comprised 43 eyes of 25 pediatric participants (mean age: 2.3±2.2 y). UBM and immersion A-scan biometry were performed prior to dilation and intraocular surgery
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Multimode Ultrasound Model for Predicting the Early Treatment Response of Anti-VEGF Agents Plus Anti-PD-1 Antibody in Patients with Unresectable Hepatocellular Carcinoma Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-12 Zi-Nan Liang, Hong Wang, Wen-Chao Cui, Wei Zhou, Song Wang, Zhong-Yi Zhang, Wei Wu, Kun Yan, Yong-Li Ji, Wei Yang
The purpose of the study described was to establish prediction models to initially screen the beneficiary patients with unresectable hepatocellular carcinoma (HCC) in the treatment of anti-vascular endothelial growth factor (VEGF) agents plus anti-programmed cell death-1 (PD-1) antibody. A total of 62 patients were enrolled in this study. All patients underwent ultrasound (US), color ddoppler flowing
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Technical Note: Impact of Linear Array Transducer Doppler Aperture Location on Spectral Peak Velocity Measurements - A Phantom Study Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-08 Zaiyang Long, Nicholas J. Hangiandreou, Thanila A. Macedo, Donald J. Tradup, Gina K. Hesley
Ultrasound beams sometimes need to be steered from the edge of linear array transducers to reach the sample volume with a desired Doppler angle in vascular exams. This phantom study aims to evaluate the impact of apertures located at the array edge on peak velocity (PV) measurements. Three ultrasound scanner systems equipped with eight transducers from 3 major ultrasound vendors were tested using a
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High-Speed Optical Characterization of Protein-and-Nanoparticle–Stabilized Microbubbles for Ultrasound-Triggered Drug Release Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-08 Charlotte L. Nawijn, Tim Segers, Guillaume Lajoinie, Sigrid Berg, Sofie Snipstad, Catharina de Lange Davies, Michel Versluis
Ultrasound-triggered bubble-mediated local drug delivery has shown potential to increase therapeutic efficacy and reduce systemic side effects, by loading drugs into the microbubble shell and triggering delivery of the payload on demand using ultrasound. Understanding the behavior of the microbubbles in response to ultrasound is crucial for efficient and controlled release. In this work, the response
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Fully Automated Localization and Measurement of Levator Hiatus Dimensions Using 3-D Pelvic Floor Ultrasound Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-05 Zhijie Guo, Xiduo Lu, Jiezhi Yao, Yongsong Zhou, Chaoyu Chen, Jiongquan Chen, Danling Yang, Yan Cao, Wei Zheng, Xin Yang, Dong Ni
To develop an algorithm for the automated localization and measurement of levator hiatus (LH) dimensions (AI-LH) using 3-D pelvic floor ultrasound. The AI-LH included a 3-D plane regression model and a 2-D segmentation model, which first achieved automated localization of the minimal LH dimension plane (C-plane) and measurement of the hiatal area (HA) on maximum Valsalva on the rendered LH images,
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A Semi-supervised Four-Chamber Echocardiographic Video Segmentation Algorithm Based on Multilevel Edge Perception and Calibration Fusion Ultrasound Med. Biol. (IF 2.4) Pub Date : 2024-06-04 Yuexin Wan, Dandan Li, Zhi Li, Jie Bu, Mutian Tong, Ruwei Luo, Baokun Yue, Shan Yu
Echocardiographic videos are commonly used for automatic semantic segmentation of endocardium, which is crucial in evaluating cardiac function and assisting doctors to make accurate diagnoses of heart disease. However, this task faces two distinct challenges: one is the edge blurring, which is caused by the presence of speckle noise or excessive de-noising operation, and the other is the lack of an