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Dysbiosis-activated IL-17-producing T cells promote skin immunopathological progression in mice deficient of the Notch ligand Jag1 in keratinocytes J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-09-06 Eun Hyeon Song, Juan Garcia Jr., Na Xiong
The Notch signaling pathway is an evolutionarily conserved regulatory cascade critical in skin development and homeostasis. Mice deficient of Notch signaling molecules have impaired skin and hair follicle development associated with local tissue inflammation. However, mechanisms underlying skin inflammation and pathology resulting from defective Notch signals are not well understood.
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Ferrostatin-1 alleviates skin inflammation and inhibits ferroptosis of neutrophils and CD8+ T cells in allergic contact dermatitis J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-08-29 Yangying Ke, Ni Lian, Yujie Chen, Yiqun Zhang, Yuancheng Li, Wenlan Zhang, Hui Yu, Heng Gu, Xu Chen
Ferroptosis is considered as an immunogenic type of regulated cell death and associated with the pathogenesis of inflammatory skin diseases. However, the involvement and function of ferroptosis in allergic contact dermatitis (ACD) remains unknown.
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Staphylococcus epidermidis augments human β-defensin-3 synthesis through the transforming growth factor alpha-epidermal growth factor receptor cascade J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-08-25 Rie Ommori, Satoru Shinkuma, Hideo Asada
Epidermal growth factor receptor inhibitors (EGFRIs) reduce β-defensin 3 (BD3) from keratinocytes stimulated by S. epidermidis, potentially leading to the development of acneiform rashes in patients undergoing EGFRIs treatment. However, the mechanism through which S. epidermidis induces BD3 via EGFR remains incompletely understood.
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Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-08-08 Seunghee Lee, Sanseul Kim, Sungjoo Tommy Hwang, Gun-Ho Kim, Ohsang Kwon
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Corrigendum to “Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions” [J. Dermatol. Sci. 113 (2024) 103–112] J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-08-01 Huan Zhang, Tao Jia, Delu Che, Bin Peng, Zhaowei Chu, Xiangjin Song, Weihui Zeng, Songmei Geng
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Corrigendum to “Dual effect of tacrolimus on mast cell-mediated allergy and inflammation through MAS-related G protein-coupled receptor-X2” [J. Dermatol. Sci. 112 (2023) 128–137] J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-07-31 Xueshan Du, Delu Che, Bin Peng, Yi Zheng, Yong Hao, Tao Jia, Xinyue Zhang, Songmei Geng
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Optimization of an adeno-associated viral vector for epidermal keratinocytes in vitro and in vivo J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-07-27 Qi Shen, Shogo Suga, Yuta Moriwaki, Zening Du, Emi Aizawa, Mutsumi Okazaki, Juan Carlos Izpisua Belmonte, Yusuke Hirabayashi, Keiichiro Suzuki, Masakazu Kurita
Local gene therapies, including in vivo genome editing, are highly anticipated for the treatment of genetic diseases in skin, especially the epidermis. While the adeno-associated virus (AAV) is a potent vector for in vivo gene delivery, the lack of efficient gene delivery methods has limited its clinical applications.
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Exposure to volatile ferroptosis inhibitor, TEMPO, reduced cutaneous ischemia-reperfusion injury progression to pressure ulcer formation in a mouse model J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-07-27 Mai Ishikawa, Akihiko Uchiyama, Keiji Kosaka, Mayu Nishio, Sachiko Ogino, Yoko Yokoyama, Ryoko Torii, Ryoko Akai, Takao Iwawaki, Seiji Torii, Sei-ichiro Motegi
Ischemia– reperfusion (I/R) injury-induced oxidative stress is a key factor in the pathogenesis of pressure ulcer formation. Ferroptosis is an iron-dependent programmed cell death that connects oxidative stress and inflammation in various diseases. Recent studies revealed the protective effect of inhibition of ferroptosis in I/R injury. However, the role of ferroptosis in cutaneous I/R injury remains
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Semaxanib, a VEGF inhibitor, suppresses melanogenesis by modulating CRTC3 independently of VEGF signaling J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-07-22 HyeJi Kwon, Jeong Hyeon Lee, Jae Min Yoo, Huonggiang Nguyen, Hongchan An, Sung Eun Chang, Youngsup Song
Dysregulation of melanogenesis contributes to the development of skin hyperpigmentation diseases, which poses a treatment challenge. Following the establishment of CRTC3 screening methods to explore small molecules inhibiting melanogenesis for the topical treatment of hyperpigmentation diseases, we identified a candidate molecule, semaxanib.
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Recombinant human thioredoxin ameliorates imiquimod-induced psoriasis-like dermatitis in mice J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-07-14 Alshimaa Mostafa, Kenji Sakurai, Teruasa Murata, Teruki Dainichi, Hai Tian, Junji Yodoi, Kenji Kabashima
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Integration of line-field confocal optical coherence tomography and in situ microenvironmental mapping to investigate the living microenvironment of reconstructed human skin and melanoma models J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-07-10 Elisabetta Michielon, Alexandre C. Motta, Jonas Ogien, Paul Oranje, Taco Waaijman, Varsha Thakoersing, Sanne Veldhorst, Tanja D. de Gruijl, Susan Gibbs
In tissue engineering, real-time monitoring of tumors and of the dynamics of the microenvironment within models has traditionally been hindered by the need to harvest the cultures to obtain material to analyze. Line-field confocal optical coherence tomography (LC-OCT) has proven to be useful in evaluating skin conditions, including melanoma, by capturing dynamic, three-dimensional (3D) information
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Revealing the UV response of melanocytes in xeroderma pigmentosum group A using patient-derived induced pluripotent stem cells J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-06-22 Chihiro Takemori, Michiyo Koyanagi-Aoi, Takeshi Fukumoto, Makoto Kunisada, Kazumasa Wakamatsu, Shosuke Ito, Chieko Hosaka, Seiji Takeuchi, Akiharu Kubo, Takashi Aoi, Chikako Nishigori
Xeroderma pigmentosum (XP) is characterized by photosensitivity that causes pigmentary disorder and predisposition to skin cancers on sunlight-exposed areas due to DNA repair deficiency. Patients with XP group A (XP-A) develop freckle-like pigmented maculae and depigmented maculae within a year unless strict sun-protection is enforced. Although it is crucial to study pigment cells (melanocytes: MCs)
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Dysregulated tryptophan metabolism and AhR pathway contributed to CXCL10 upregulation in stable non-segmental vitiligo J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-06-21 Zile Chen, Yiting Li, Xi Tan, Shu Nie, Bin Chen, Xingyu Mei, Zhouwei Wu
Tryptophan metabolism dysregulation has been observed in vitiligo. However, drawing a mechanistic linkage between this metabolic disturbance and vitiligo pathogenesis remains challenging. Aim to reveal the characterization of tryptophan metabolism in vitiligo and investigate the role of tryptophan metabolites in vitiligo pathophysiology. LC-MS/MS, dual-luciferase reporter assay, ELISA, qRT-PCR, small
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Topical application of a BCL-2 inhibitor ameliorates imiquimod-induced psoriasiform dermatitis by eliminating senescent cells J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-06-18 Huan Zhu, Jiao Jiang, Ming Yang, Mingming Zhao, Zhenghao He, Congli Tang, Cailing Song, Ming Zhao, Arne N. Akbar, Venkat Reddy, Wenjing Pan, Song Li, Yixin Tan, Haijing Wu, Qianjin Lu
Psoriasis is an inflammatory skin disease with unclear pathogenesis and unmet therapeutic needs. To investigate the role of senescent CD4 T cells in psoriatic lesion formation and explore the application of senolytics in treating psoriasis. We explored the expression levels of p16 and p21, classical markers of cellular senescence, in CD4 T cells from human psoriatic lesions and imiquimod (IMQ)-induced
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miR-25–5p in exosomes derived from UVB-induced fibroblasts regulates melanogenesis via TSC2-dominated cellular organelle dysfunction J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-06-10 Hedan Yang, Xiaoli Zhang, Wenzhu Wang, Yiping Ge, Yin Yang, Tong Lin
Few reports have confirmed whether exosomes derived from fibroblasts can regulate the process of melanogenesis. We wondered whether exosomes derived from fibroblasts could have a potent regulatory effect on melanogenesis and explored the underlying mechanisms. This study aimed to find the role of fibroblasts in melanocytes and revealed the related mechanisms. RT-qPCR, Western blot analysis were conducted
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Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-05-29 Akinori Matsuda, Toshio Hasegawa, Yuri Ikeda, Akino Wada, Shigaku Ikeda
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin fragility disorder caused by mutations in the gene, which encodes type VII collagen (COL7), the main constituent of anchoring fibrils for attaching the epidermis to the dermis. Persistent skin erosions frequently result in intractable ulcers in RDEB patients. Adipose-derived mesenchymal stromal cells (AD-MSCs) are easily harvested in
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Comprehensive analysis of phenotypes and transcriptome characteristics reveal the best atopic dermatitis mouse model induced by MC903 J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-05-18 Shan Zhang, Xiaokai Fang, Beilei Xu, Yuan Zhou, Fang Li, Yuwen Gao, Yang Luo, Xu Yao, Xiaochun Liu
Although several mouse models of exogenous-agentinduced atopic dermatitis (AD) are currently available, the lack of certainty regarding their similarity with human AD has limited their scientific value. Thus, comprehensive evaluation of the characteristics of mouse models and their similarity with human AD is essential. To compare six different exogenous-agentinduced AD mouse models and find out the
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Foxp3+ Treg control allergic skin inflammation by restricting IFN-γ-driven neutrophilic infiltration and NETosis J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-05-09 Xinjie Tong, Sung Hee Kim, Lihua Che, Jeyun Park, Joohee Lee, Tae-Gyun Kim
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Mucopolysaccharide polysulfate increases local skin blood volume through nitric oxide production J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-05-09 Tam Kurachi, Hironobu Ishimaru, Ryo Tadakuma, Miu Okaue, Akira Koda, Yuhki Ueda, Takaaki Doi
Mucopolysaccharide polysulfate (MPS) is widely used as an active ingredient in topical preparations for the treatment of asteatosis and blood flow disorders. Although topical MPS products can increase cutaneous blood flow (CBF), the underlying mechanism remains unclear. In this study, we aimed to elucidate how MPS increases CBF. We investigated the association of nitric oxide (NO), a powerful mediator
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Necrosulfonamide promotes hair growth and ameliorates DHT-induced hair growth inhibition J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-04-26 Yuanhong Liu, Shengbo Yang, Lina Tan, Xuemei Li, Daijing Long, Jianyun Lu, Dan Wang
Alopecia affects patients' appearance and psychology. Mixed-lineage kinase domain-like pseudokinase (MLKL)-mediated necroptosis plays a role in various skin diseases, but its effect on hair growth is unclear. To investigate the effects of MLKL on hair growth and its regulatory mechanisms and to determine the potential clinical value of Necrosulfonamide (NSA, a MLKL-targeting inhibitor) in promoting
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Differences in activation of β-catenin in outer root sheath cells between the type of JAK inhibitor: An alternative mechanism promoting hair growth by JAK inhibitors in alopecia areata J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-04-26 Jung-Min Shin, Yeounkuk Sung, Dongkyun Hong, Kyung-Eun Jung, Young-Joon Seo, Chang-Deok Kim, Young Lee
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Metabolome analyses of skin dialysate: Insights into skin interstitial fluid biomarkers J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-04-26 Akihiko Oharazawa, Gulinu Maimaituxun, Koichi Watanabe, Takeshi Nishiyasu, Naoto Fujii
Metabolites in biofluids can serve as biomarkers for diagnosing diseases and monitoring body conditions. Among the available biofluids, interstitial fluid (ISF) in the skin has garnered considerable attention owing to its advantages, which include inability to clot, easy access to the skin, and possibility of incorporating wearable devices. However, the scientific understanding of skin ISF composition
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Obituary: Thomas Fletcher Tedder, PhD (1956–2024) J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-04-23 Minoru Hasegawa, Manabu Fujimoto, Takafumi Kadono, Yasuhiro Fujisawa, Masahiro Kamata, Takashi Matsushita, Shinichi Sato
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Senescent fibroblasts and innate immune cell activation might play a role in the pathogenesis of elderly atopic dermatitis J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-04-18 Yang Luo, Xiaokai Fang, Yuan Zhou, Yu Zhang, Wei Li, Sean X. Leng, Xu Yao, Xiaochun Liu
Elderly atopic dermatitis (AD) is a subtype of AD defined by age (≥ 60 years). The molecular characteristics of elderly AD remain to be clarified. We sought to characterize the molecular features of skin lesions and peripheral blood mononuclear cells (PBMCs) in patients with AD across different age, focusing on elderly AD. Skin and PBMCs samples were used for RNA sequencing. Analysis of differentially
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Enhancement of skin barrier function and augmentation of epidermal cell-cell interactions by galactomyces ferment filtrate J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-30 Satoshi Nakamizo, Xianghong Yan, Kenji Kabashima
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Visualization of intradermal blood vessel structures by dual-wavelength photoacoustic microscopy and characterization of three-dimensional construction of livedo-racemosa in cutaneous polyarteritis nodosa J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-26 Kazuyo Sujino, Keiji Tanese, Yasuko Saito, Junko Kuramoto, Hideaki Iwazaki, Taiichiro Ida, Sadakazu Aiso, Nobuaki Imanishi, Hiroki Kajita, Keitaro Fukuda, Masayuki Amagai, Akiko Tanikawa
Photoacoustic microscopy is expected to have clinical applications as a noninvasive and three-dimensional (3D) method of observing intradermal structures. Investigate the applicability of a photoacoustic microscope equipped with two types of pulsed lasers that can simultaneously recognize hemoglobin and melanin. 16 skin lesions including erythema, pigmented lesions, vitiligo and purpura, were analyzed
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Lack of cutis verticis gyrata is associated with c.1279_1290del12 of SLCO2A1 in 43 Japanese patients with pachydermoperiostosis J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-26 H. Niizeki, R. Tanaka, T. Nomura, A. Seki, M. Miyasaka, Y. Matsumoto, M. Ishibashi, S. Narumi, K. Nakabayashi, K. Yoshida
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Anti-BP230 IgE autoantibodies in bullous pemphigoid intraindividually correlate with disease activity J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-23 Shirin Emtenani, Beke E. Linnemann, Andreas Recke, Anabelle von Georg, Stephanie Goletz, Enno Schmidt, Nina van Beek
Bullous pemphigoid (BP), the most common subepidermal autoimmune blistering disease, is classically defined by the presence of IgG autoantibodies directed against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230 and the predominance of skin lesions. Several studies have addressed the role of anti-BP180 IgE in patients and experimental models, while data on anti-BP230 IgE are scarce
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IL-4-induced decrease in both the number and CTLA-4 expression of Treg impairs suppression of Th2 type inflammation in severe atopic dermatitis J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-23 Bocheng Wang, Zhiying Yu, Jiao Liu, Yuyang Tian, Yijia Ruan, Tinghui Kong, Mingjun Hou, Bihui Yu, Shiqi Ling, Di Wang, Yishan Chen, Yingping Xu, Weiwei Deng, Yunsheng Liang
T plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of T suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive. This study aims to investigate the molecular mechanism underlying quantitative and functional changes of T in AD. The molecular mechanism
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Proteome characterization of XPC-deficient melanocytes generated by CRISPR-Cas9 technology reveals alteration in the expression of several hundred proteins J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-23 Muriel Cario, Julie Scalia, Walid Mahfouf, Elodie Muzotte, Vincent Michaud, Claudio Plaisant, Jean-William Dupuy, Thierry Douki, Fanny Morice-Picard, Jérôme Rambert, Eric Perrier, Sandra Trompezinski, Hamid-Reza Rezvani
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Maximizing the potential of biobanks in dermatology research J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-22 Alison M. Treichel, Jacky H.K. Chen, Samantha Epstein, Thomas S. McCormick, Jeremy S. Bordeaux, David J. Alouani, Kevin D. Cooper
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JSID’s Fellowship Shiseido Research Grant J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-14 Manabu Ohyama
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LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-13 Pascal Canbolat, Jenny Wilzopolski, Sabine Kaessmeyer, Viviane Filor, Jonathan Vidak, Marc Rüger, Hans-Jürgen Mägert, Wolf-Georg Forssmann, Wolfgang Bäumer
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease inhibitor consisting of multiple domains. A loss of function mutation is described in Netherton patients that show severe symptoms of atopic lesions and itch. LEKTI domain 6 (LD6) has shown strong serine protease-inhibitory action in assays and thus it was tested and for potential anti-inflammatory action in models of atopic
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RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-07 Laura Mercurio, Jacob Bailey, Adam Bleier Glick, Elena Dellambra, Claudia Scarponi, Sabatino Pallotta, Cristina Albanesi, Stefania Madonna
Psoriasis is a chronic immune-mediated skin disease in which upper epidermal keratinocytes exhibit a senescent-like phenotype. In psoriatic skin, a variety of inflammatory cytokines can activate intracellular pathways including phosphatidylinositol 3-kinase (PI3K)/AKT signaling and RAS effectors. AKT and RAS participate to cellular senescence, but currently their role in senescence responses occurring
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Targeting antibody-mediated complement-independent mechanism in bullous pemphigoid with diacerein J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-03-06 Yung-Tsu Cho, Chih-Hung Lee, Jing-Yi Lee, Chia-Yu Chu
Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. The pathogenesis involves both complement-dependent and complement-independent mechanisms. The therapeutic potential of targeting complement-independent mechanism has not yet been determined. The mainstay of treatment, corticosteroid, has many side effects, indicating the needs of better treatments
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Oxidative stress-induced hypermethylation and low expression of ANXA2R: Novel insights into the dysfunction of melanocytes in vitiligo J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-29 Jiaxi Chen, Yinghan Wang, Wei Dai, Xinyuan Xu, Qingrong Ni, Xiuli Yi, Pan Kang, Jingjing Ma, Lili Wu, Chunying Li, Shuli Li
Vitiligo is a skin disorder with melanocyte destruction caused by complex interplay between multiple genetic and environmental factors. Recent studies have suggested DNA methylation is involved in the melanocyte damage, but the underlying mechanism remains unknown. To explore the abnormal DNA methylation patterns in vitiligo lesional and nonlesional skin, and the mechanism of DNA methylation involved
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High α-diversity of skin microbiome and mycobiome in Japanese patients with vitiligo J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-29 Yasutaka Kuroda, Lingli Yang, Takakazu Shibata, Masahiro Hayashi, Yuta Araki, Makiko Nishida, Takeshi Namiki, Teruhiko Makino, Tadamichi Shimizu, Tamio Suzuki, Tetsuya Sayo, Yoshito Takahashi, Daisuke Tsuruta, Ichiro Katayama
Vitiligo is an acquired pigmentary disorder characterized by depigmented patches on the skin that majorly impact patients' quality of life. Although its etiology involves genetic and environmental factors, the role of microorganisms as environmental factors in vitiligo pathology remains under-researched. Our study explored the presence of characteristic bacterial and fungal flora in vitiligo-affected
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Rh family C glycoprotein contributes to psoriatic inflammation through regulating the dysdifferentiation and cytokine secretion of keratinocytes J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-29 Wei Liu, Yaqi Wang, Yitian Zhang, Mingzhu Zhou, Hanjiang Gu, Mei Lu, Yumin Xia
Keratinocyte dysdifferentiation and proinflammatory cytokine production play a central role in psoriatic inflammation. According to recent studies, the Rh family C glycoprotein (RHCG) enhances cell proliferation and disrupts cell differentiation. However, the specific role of RHCG psoriasis development remains unclear. We here explored the effect of RHCG on keratinocytes under psoriatic inflammation
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KTN1 mediated unfolded protein response protects keratinocytes from ionizing radiation-induced DNA damage J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-24 Xinli Niu, Yi Shen, Yunhan Wen, Xing Mi, Jing Xie, Ying Zhang, Zhenhua Ding
The unfolded protein response (UPR) is one of the cytoprotective mechanisms against various stresses and essential for the normal function of skin. Skin injury caused by ionizing radiation (IR) is a common side effect of radiotherapy and it is unclear how UPR affects IR-induced skin injury. To verify the effect of UPR on IR-induced DNA damage in keratinocytes and the relation between an endoplasmic
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DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-18 Takeshi Fukumoto, Tomoka Harada, Takamichi Ito, Satoshi Fukushima, Ryusuke Ono, Masutaka Furue, Chikako Nishigori
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Combined effect of Neurotropin® and methylcobalamin on postherpetic neuralgia in mice infected with herpes simplex virus type-1 J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-12 Tsugunobu Andoh, Takashi Kikukawa, Atsushi Kotani, Yoko Kurokawa, Wakana Asakura, Kengo Houmoto, Daisuke Fukutomi, Daisuke Uta, Hisashi Okai, Koji Koike
Postherpetic pain (PHP) is difficult to control. Although Neurotropin® (NTP) and methylcobalamin (MCB) are often prescribed to treat the pain, the efficacy of combined treatment for PHP remains imcompletely understood. In this study, we investigate the combined effects of NTP and MCB on PHP in mice. NTP and MCB were administered from day 10–29 after herpes simplex virus type-1 (HSV-1) infection. The
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The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750 J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-12 Xue-ting Hu, Xiao-feng Wu, Lu-min Sui, Luo-quan Ao, Cheng-xiu Pu, Mu Yuan, Wei Xing, Xiang Xu
Aberrant keratinocytes differentiation has been demonstrated to be associated with a number of skin diseases. The roles of lncRNAs in keratinocytes differentiation remain to be largely unknown. Here we aim to investigate the role of lnc-DC in regulating epidermal keratinocytes differentiation. Expression of lnc-DC in the skin was queried in AnnoLnc and verified by FISH. The lncRNA expression profiles
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Acquired curved hair is caused by fusion of multiple hair matrix cells J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-12 Ippei Horibe, Sara Izumi, Yuru Ke, Nanami Tanahashi, Yusuke Takagi, Ryoji Ishihara, Takaya Nakano, Takaaki Sumiyoshi, Yasuo Nagaoka
“Curved hair” caused by acquired factors is considered to have adverse cosmetic effects, but the detailed mechanism behind curved hair remains obscure. We attempted to clarify the causes of curved hair that appeared to have occurred via acquired factors. Outer root sheath cells (ORSC) isolated from plucked human hair follicles were used to evaluate the expression of type IV collagen. Straight and curved
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Calcitriol modulates epidermal tight junction barrier function in human keratinocytes J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-02-07 Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura, François Niyonsaba
The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided thus far suggests an important role of calcitriol in skin homeostasis. However, it is not known whether calcitriol improves the impaired skin barrier. To investigate the effect of calcitriol
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A Staphylococcus epidermidis strain inhibits the uptake of Staphylococcus aureus derived from atopic dermatitis skin into the keratinocytes J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-30 Tomofumi Numata, Kazumasa Iwamoto, Kyouka Matsunae, Ryu Miyake, Masataka Suehiro, Nozomi Yanagida, Takanobu Kan, Shunsuke Takahagi, Michihiro Hide, Akio Tanaka
Various bacterial species form a microbiome in the skin. In the past, dead derived from atopic dermatitis (AD) are taken up by keratinocytes; however, whether live can be taken up by keratinocytes is unknown. This study aimed to examine whether live AD strains of internalize into the keratinocytes and how the internalization changes under conditions in which other bacterial species including are present
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Mass spectrometry -based proteomic analysis of the skin of patients with localized scleroderma J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-25 Katariina Mähönen, Salla Keskitalo, Kari Salokas, Antti Tuhkala, Jaana Panelius, Annamari Ranki, Markku Varjosalo
Abstract not available
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Resident memory T cell contributes to the phenotype of inflammatory vitiligo J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-20 Ken Okamura, Takanobu Kabasawa, Toru Saito, Yosuke Arai, Mitsuru Futakuchi, Tamio Suzuki
Abstract not available
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Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-20 Huan Zhang, Tao Jia, Delu Che, Bin Peng, Zhaowei Chu, Xiangjin Song, Weihui Zeng, Songmei Geng
TET2 participates in tumor progression and intrinsic immune homeostasis via epigenetic regulation. TET2 has been reported to be involved in maintaining epithelial barrier homeostasis and inflammation. Abnormal epidermal barrier function and TET2 expression have been detected in psoriatic lesions. However, the mechanisms underlying the role of TET2 in psoriasis have not yet been elucidated. To define
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Proteomic changes related to actin cytoskeleton function in the skin of vildagliptin-treated mice J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-20 Antti Nätynki, Nina Kokkonen, Jussi Tuusa, Steffen Ohlmeier, Ulrich Bergmann, Kaisa Tasanen
Vildagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i) is a widely used type 2 diabetes medication that is associated with an up-to 10-fold increased risk for the development of bullous pemphigoid (BP), an autoimmune skin disease. The mechanism by which vildagliptin promotes the development of BP remains unknown. To elucidate effects of vildagliptin treatment on the mouse cutaneous proteome. We
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JAK inhibitors for the treatment of vitiligo J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-11 Shintaro Inoue, Tamio Suzuki, Shigetoshi Sano, Ichiro Katayama
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FTO-mediated regulation of m6A methylation is closely related to apoptosis induced by repeated UV irradiation J. Dermatol. Sci. (IF 3.8) Pub Date : 2024-01-09 Yao Lin, Yu Sun, Wenyi Hou, Xinling Chen, Feng Zhou, QingFang Xu, Yue Zheng
Ultraviolet (UV) damage is closely related to skin photoaging and many skin diseases, including dermatic tumors. N6-methyladenosine (m6A) modification is an important epigenetic regulatory mechanism. However, the role of m6A methylation in apoptosis induced by repeated UV irradiation has not been characterized. To explore m6A methylation changes and regulatory mechanisms in the repeated UV-induced
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Transcriptome network analysis of inflammation and fibrosis in keloids J. Dermatol. Sci. (IF 3.8) Pub Date : 2023-12-27 Jiayi Mao, Lu Chen, Shutong Qian, Yuhuan Wang, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Xiyuan Mao, Peisong Zhai, Yuguang Zhang, Liucheng Zhang, Xiaoming Sun
Keloid (KL) is a common benign skin tumor. KL is typically characterized by significant fibrosis and an intensive inflammatory response. Therefore, a comprehensive understanding of the interactions between cellular inflammation and fibrotic cells is essential to elucidate the mechanisms driving the progression of KL and to develop therapeutics. Investigate the transcriptome landscape of inflammation
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Exosomes containing miR-1469 regulate natural killer cells by targeting CD122 in non-segmental vitiligo J. Dermatol. Sci. (IF 3.8) Pub Date : 2023-12-24 Yujia Wei, Ting Zhou, Ronghua Pan, Xiaoqi Nie, Zhong Liu, Zeqi Shi, Ying Zeng, Ri Zhang, Yunhua Deng, Dong Li
Plasma exosomal microRNAs (miRNAs) have been used as potential biomarkers for various diseases and have been investigated for their possible involvement in the pathogenesis of vitiligo. However, the miRNA expression profile of plasma exosomes in patients with non-segmental vitiligo (NSV) has not been determined yet. To screen differentially expressed microRNAs in plasma exosomes derived from patients
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Low-dose imiquimod induces melanogenesis in melanoma cells through an ROS-mediated pathway J. Dermatol. Sci. (IF 3.8) Pub Date : 2023-12-22 Zheng-Yi Li, Shu-Hao Chang, Kuang-Ting Liu, Alaina Edelie Wu, Chien-Sheng Hsu, Shi-Wei Huang, Mu-Chi Chung, Shih-Chung Wang, Jun-Kai Kao, Yi-Ju Chen, Jeng-Jer Shieh
Background Melanogenesis is the process of melanin maturation which not only protects skin from UV radiation but also plays an important role in antigenicity of melanomas. Imiquimod (IMQ) is a toll-like receptor 7 (TLR7) agonist that exhibits antiviral and anticancer activity. Objective To explore whether IMQ could induce melanogenesis in melanoma cells. Methods The mouse melanoma cell line B16F10
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