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Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women Respir. Res. (IF 5.8) Pub Date : 2024-03-16 Magnus Ekström, Josefin Sundh, Anders Andersson, Oskar Angerås, Anders Blomberg, Mats Börjesson, Kenneth Caidahl, Össur Ingi Emilsson, Jan Engvall, Erik Frykholm, Ludger Grote, Kristofer Hedman, Tomas Jernberg, Eva Lindberg, Andrei Malinovschi, André Nyberg, Eric Rullman, Jacob Sandberg, Magnus Sköld, Nikolai Stenfors, Johan Sundström, Hanan Tanash, Suneela Zaigham, Carl-Johan Carlhäll
Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population. Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50–64 years. Breathlessness (modified Medical Research Council [mMRC] ≥ 2) was evaluated
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Identifying a survival-associated cell type based on multi-level transcriptome analysis in idiopathic pulmonary fibrosis Respir. Res. (IF 5.8) Pub Date : 2024-03-15 Fei Xu, Yun Tong, Wenjun Yang, Yiyang Cai, Meini Yu, Lei Liu, Qingkang Meng
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a five-year survival rate of less than 40%. There is significant variability in survival time among IPF patients, but the underlying mechanisms for this are not clear yet. We collected single-cell RNA sequence data of 13,223 epithelial cells taken from 32 IPF patients and bulk RNA sequence data from 456 IPF patients in GEO. Based on
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Alterations of lung microbiota in lung transplant recipients with pneumocystis jirovecii pneumonia Respir. Res. (IF 5.8) Pub Date : 2024-03-14 Qiaoyan Lian, Xiuling Song, Juhua Yang, Lulin Wang, Peihang Xu, Xiaohua Wang, Xin Xu, Bin Yang, Jianxing He, Chunrong Ju
Increasing evidence revealed that lung microbiota dysbiosis was associated with pulmonary infection in lung transplant recipients (LTRs). Pneumocystis jirovecii (P. jirovecii) is an opportunistic fungal pathogen that frequently causes lethal pneumonia in LTRs. However, the lung microbiota in LTRs with P. jirovecii pneumonia (PJP) remains unknow. In this prospective observational study, we performed
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Efficacy and safety of Infliximab in systemic sarcoidosis according to GenPhenReSa organ-involvement phenotype: a retrospective study of 55 patients Respir. Res. (IF 5.8) Pub Date : 2024-03-14 Etienne Rivière, Wendy Jourde, Noémie Gensous, Xavier Demant, Emmanuel Ribeiro, Pierre Duffau, Patrick Mercié, Jean-François Viallard, Estibaliz Lazaro
Infliximab is currently recommended as a third-line treatment for refractory sarcoidosis. Data in function of clinical phenotype are currently lacking. We evaluated patients’ characteristics and responses to infliximab according to their GenPhenReSa cluster. We evaluated clinical and biological characteristics of patients diagnosed with sarcoidosis who received infliximab between September 2008 and
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Variables associated with antibiotic treatment tolerance in patients with Mycobacterium avium complex pulmonary disease Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Meghan Marmor, Husham Sharifi, Susan Jacobs, Kiana Fazeli, Stephen Ruoss
Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) involves prolonged courses of multiple antibiotics that are variably tolerated and commonly cause adverse drug reactions (ADR). The purpose of this retrospective, single-center study was to identify demographic and disease-related variables associated with significant ADRs among patients treated with antibiotics against MAC-PD. We
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Associations of a plant-centered diet and lung function across early to mid-adulthood: The CARDIA Lung Study Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Robert C. Wharton, Jing Gennie Wang, Yuni Choi, Elliot Eisenberg, Mariah K. Jackson, Corrine Hanson, Bian Liu, George R. Washko, Ravi Kalhan, David R. Jacobs, Sonali Bose
Lung function throughout adulthood predicts morbidity and mortality even among adults without chronic respiratory disease. Diet quality may represent a modifiable risk factor for lung function impairment later in life. We investigated associations between nutritionally-rich plant-centered diet and lung function across early and middle adulthood from the Coronary Artery Risk Development in Young Adults
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Cardiopulmonary exercise test to detect cardiac dysfunction from pulmonary vascular disease Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Mona Alotaibi, Jenny Z. Yang, Demosthenes G. Papamatheakis, W. Cameron McGuire, Timothy M. Fernandes, Timothy A. Morris
Cardiac dysfunction from pulmonary vascular disease causes characteristic findings on cardiopulmonary exercise testing (CPET). We tested the accuracy of CPET for detecting inadequate stroke volume (SV) augmentation during exercise, a pivotal manifestation of cardiac limitation in patients with pulmonary vascular disease. We reviewed patients with suspected pulmonary vascular disease in whom CPET and
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Quercetin improves epithelial regeneration from airway basal cells of COPD patients Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Elizabeth S. McCluskey, Nathan Liu, Abhimaneu Pandey, Nathaniel Marchetti, Steven G. Kelsen, Umadevi S. Sajjan
Airway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was associated with reduced expression of several genes involved in epithelial repair. Quercetin reduces airway epithelial remodeling and inflammation in COPD models, therefore we examined whether quercetin promotes normal epithelial regeneration from COPD BC by altering
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Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma Respir. Res. (IF 5.8) Pub Date : 2024-03-08 Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng
The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation. Recent studies have revealed that Dectin-1 is overexpressed in asthma, but the specific mechanism remains elusive. Additionally, Dectin-1 has been implicated in promoting pyroptosis, a hallmark of severe asthma airway inflammation
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Circulating miRNAs associate with historical childhood asthma hospitalization in different serum vitamin D groups Respir. Res. (IF 5.8) Pub Date : 2024-03-08 Xiaoning Hong, Mingye Jiang, Alvin T. Kho, Anshul Tiwari, Haiyan Guo, Alberta L. Wang, Michael J. McGeachie, Scott T. Weiss, Kelan G. Tantisira, Jiang Li
Vitamin D may help to alleviate asthma exacerbation because of its anti-inflammation effect, but the evidence is inconsistent in childhood asthma. MiRNAs are important mediators in asthma pathogenesis and also excellent non-invasive biomarkers. We hypothesized that circulating miRNAs are associated with asthma exacerbation and modified by vitamin D levels. We sequenced baseline serum miRNAs from 461
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MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery Respir. Res. (IF 5.8) Pub Date : 2024-03-07 Judith van Paassen, Pieter S. Hiemstra, Abraham C. van der Linden, Evert de Jonge, Jaap Jan Zwaginga, Robert J.M. Klautz, M. Sesmu Arbous
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes
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Differences of respiratory mechanics in mechanical ventilation of acute respiratory distress syndrome between patients with COVID-19 and Influenza A Respir. Res. (IF 5.8) Pub Date : 2024-03-07 Eunki Chung, Ah Young Leem, Kyung Soo Chung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Hye Jin Jang, Su Hwan Lee
Whether COVID-19-induced acute respiratory distress syndrome (ARDS) should be approached differently in terms of mechanical ventilation therapy compared to other virus-induced ARDS is debatable. Therefore, we aimed to ascertain whether the respiratory mechanical characteristics of COVID-19-induced ARDS differ from those of influenza A induced ARDS, in order to establish a rationale for mechanical ventilation
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Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Yixing Wu, Binfeng He, Jianlan Hua, Weiping Hu, Yaopin Han, Jing Zhang
Chronic obstructive pulmonary disease (COPD) is a significant public health problem characterized by persistent airflow limitation. Despite previous research into the pathogenesis of COPD, a comprehensive understanding of the cell-type-specific mechanisms in COPD remains lacking. Recent studies have implicated Rab GTPases in regulating chronic immune response and inflammation via multiple pathways
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Association and mediation between educational attainment and respiratory diseases: a Mendelian randomization study Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Guohui Lan, Mengying Xie, Jieli Lan, Zelin Huang, Xiaowei Xie, Mengdan Liang, Zhehui Chen, Xiannuan Jiang, Xiaoli Lu, Xiaoying Ye, Tingting Xu, Yiming Zeng, Xiaoxu Xie
Respiratory diseases are a major health burden, and educational inequalities may influence disease prevalence. We aim to evaluate the causal link between educational attainment and respiratory disease, and to determine the mediating influence of several known modifiable risk factors. We conducted a two-step, two-sample Mendelian randomization (MR) analysis using summary statistics from genome-wide
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Response to: are there over 200 distinct types of interstitial lung diseases? Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Francesco Amati, Anna Stainer, Stefano Aliberti
We’d like to thank Cooley and Fernandez-Perez for their thoughtful comments and feedback on our article. The Authors underline that using standard classification schemes of interstitial lung disease (ILD) clinical diagnoses, the number of unique ILDs is far from exceeding 200. Moreover, the Authors noticed that this number is frequently reported in several papers. Depending on how you want to slice
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Disease trajectories in interstitial lung diseases – data from the EXCITING-ILD registry Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Katharina Buschulte, Hans-Joachim Kabitz, Lars Hagmeyer, Peter Hammerl, Albert Esselmann, Conrad Wiederhold, Dirk Skowasch, Christoph Stolpe, Marcus Joest, Stefan Veitshans, Marc Höffgen, Phillen Maqhuzu, Larissa Schwarzkopf, Andreas Hellmann, Michael Pfeifer, Jürgen Behr, Rainer Karpavicius, Andreas Günther, Markus Polke, Philipp Höger, Vivien Somogyi, Christoph Lederer, Philipp Markart, Michael Kreuter
Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with different disease trajectories. Progression (PF-ILD) occurs in up to 50% of patients and is associated with increased mortality. The EXCITING-ILD (Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases) registry was analysed for disease trajectories in different ILD. The
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Self-administered at-home lung ultrasound with remote guidance in patients without clinical training Respir. Res. (IF 5.8) Pub Date : 2024-03-05 Nika Elmi, Yasmin Sadri, Frank Myslik, Jordan Chenkin, William Cherniak
Access to timely and accurate diagnostic imaging is essential for high-quality healthcare. Point-of-care ultrasound has been shown to be accessible and effective in many aspects of healthcare, including assessing changes in lung pathology. However, few studies have examined self-administered at-home lung ultrasound (SAAH-LUS), in particular performed by non-clinical patients (NCPs). Are NCPs able to
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Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis Respir. Res. (IF 5.8) Pub Date : 2024-03-02 Wenhui Huang, Lianfang Wang, Zhipeng Huang, Zhichao Sun, Bojun Zheng
Acute lung injury (ALI) is one of the life-threatening complications of sepsis, and macrophage polarization plays a crucial role in the sepsis-associated ALI. However, the regulatory mechanisms of macrophage polarization in ALI and in the development of inflammation are largely unknown. In this study, we demonstrated that macrophage polarization occurs in sepsis-associated ALI and is accompanied by
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Prognosis of mechanically ventilated patients with COVID-19 after failure of high-flow nasal cannula: a retrospective cohort study Respir. Res. (IF 5.8) Pub Date : 2024-03-01 Dong-gon Hyun, Su Yeon Lee, Jee Hwan Ahn, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
There is an argument whether the delayed intubation aggravate the respiratory failure in Acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). We aimed to investigate the effect of high-flow nasal cannula (HFNC) failure before mechanical ventilation on clinical outcomes in mechanically ventilated patients with COVID-19. This retrospective cohort study included
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FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Zhenyu Hu, Jindan Dai, Tianpeng Xu, Hui Chen, Guoxiu Shen, Jie Zhou, Hongfang Ma, Yang Wang, Litai Jin
Acute lung injury (ALI) is a devastating clinical disorder with a high mortality rate, and there is an urgent need for more effective therapies. Fibroblast growth factor 18 (FGF18) has potent anti-inflammatory properties and therefore has become a focus of research for the treatment of lung injury. However, the precise role of FGF18 in the pathological process of ALI and the underlying mechanisms have
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Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Pierre-Francois Clot, Christine Farenc, Benjamin T. Suratt, Tillmann Krahnke, Agnes Tardat, Peter Florian, Robert Pomponio, Naimish Patel, Maria Wiekowski, Yong Lin, Benjamin Terrier, Heribert Staudinger
Targeting receptor-interacting serine/threonine protein kinase 1 could mitigate the devastating sequelae of the hyperinflammatory state observed in severe cases of COVID-19. This study explored the immunomodulatory and clinical effects of the receptor-interacting serine/threonine protein kinase 1 inhibitor SAR443122 (eclitasertib) in patients with severe COVID-19. In this Phase 1b, double-blinded,
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Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Alexander J. Bell, Ravi Pal, Wassim W. Labaki, Benjamin A. Hoff, Jennifer M. Wang, Susan Murray, Ella A. Kazerooni, Stefanie Galban, David A. Lynch, Stephen M. Humphries, Fernando J. Martinez, Charles R. Hatt, MeiLan K. Han, Sundaresh Ram, Craig J. Galban
Small airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapping (PRM) approach, the full breadth of this readout as a measure of emphysema and COPD progression has yet to be explored. We evaluated topological features of PRM-derived
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Associations between long-term ozone exposure and small airways function in Chinese young adults: a longitudinal cohort study Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Shurong Feng, Liu Yang, Siqi Dou, Xinyuan Li, Shuo Wen, Lailai Yan, Wenzhong Huang, Yiwen Zhang, Bin Ma, Linghong Yuan, Shanshan Li, Peng Lu, Yuming Guo
Increasing evidence is appearing that ozone has adverse effects on health. However, the association between long-term ozone exposure and lung function is still inconclusive. To investigate the associations between long-term exposure to ozone and lung function in Chinese young adults. We conducted a prospective cohort study among 1594 college students with a mean age of 19.2 years at baseline in Shandong
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The effect of combining an inhaled corticosteroid and a long-acting muscarinic antagonist on human airway epithelial cells in vitro Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Maria Gabriella Matera, Barbara Rinaldi, Cecilia Calabrese, Carmela Belardo, Luigino Calzetta, Mario Cazzola, Clive Page
Airway epithelial cells (AECs) are a major component of local airway immune responses. Direct effects of type 2 cytokines on AECs are implicated in type 2 asthma, which is driven by epithelial-derived cytokines and leads to airway obstruction. However, evidence suggests that restoring epithelial health may attenuate asthmatic features. We investigated the effects of passive sensitisation on IL-5, NF-κB
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Association between body fat decrease during the first year after diagnosis and the prognosis of idiopathic pulmonary fibrosis: CT-based body composition analysis Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Ji Young Lee, Soon Ho Yoon, Jin Mo Goo, Jimyung Park, Jong Hyuk Lee
The prognostic role of changes in body fat in patients with idiopathic pulmonary fibrosis (IPF) remains underexplored. We investigated the association between changes in body fat during the first year post-diagnosis and outcomes in patients with IPF. This single-center, retrospective study included IPF patients with chest CT scan and pulmonary function test (PFT) at diagnosis and a one-year follow-up
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P80 natural essence spray and lozenges provide respiratory protection against Influenza A, B, and SARS-CoV-2 Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Viktoria Zaderer, Gabriel Diem, Wilfried Posch, Thomas Jakschitz, Günther K. Bonn, Rosa Bellmann-Weiler, Lukas A. Huber, Doris Wilflingseder
Seasonally circulating viruses, such as Influenza, as well as newly emerging viruses and variants thereof, and waning immunity urge the need for safe, easy-to-use and inexpensive drugs to protect from these challenges. To prevent transmission of these viruses and subsequent excessive inflammatory reactions on mucous membranes, we tested the efficacy of the natural essence P80 as spray and in form of
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Psoriasis may increase the risk of idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study Respir. Res. (IF 5.8) Pub Date : 2024-02-26 Lingli Chen, Yujie Wei, Mengjin Hu, Yile Liu, Xiangrong Zheng
Although some studies have indicated that Psoriasis could contribute to the risk of idiopathic pulmonary fibrosis (IPF), no study has reported a clear causal association between them. Our aim was to explore the potential relationship between Psoriasis and IPF using Mendelian randomization (MR) design. To explore a causal association between Psoriasis and IPF, we used genetic instruments from the largest
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Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis Respir. Res. (IF 5.8) Pub Date : 2024-02-24 Xingxing Hu, Menglin Zou, Weishuai Zheng, Minghui Zhu, Qinhui Hou, Han Gao, Xin Zhang, Yuan Liu, Zhenshun Cheng
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) as common life-threatening lung diseases with high mortality rates are mostly associated with acute and severe inflammation in lungs. Recently, increasing evidence supports activated inflammation and gasdermin D (GSDMD)-mediated pyroptosis in macrophage are closely associated with ALI. Basic helix-loop-helix
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Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort Respir. Res. (IF 5.8) Pub Date : 2024-02-24 Valérie Siroux, Anne Boudier, Sarah Lyon-Caen, Joane Quentin, Yoann Gioria, Zoltán Hantos, Rémy Slama, Isabelle Pin, Sam Bayat
Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children. History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory
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Correction to: Association between cigar use, with and without cigarettes, and incident diagnosed COPD: a longitudinal cohort study Respir. Res. (IF 5.8) Pub Date : 2024-02-23 Steven Cook, James H. Buszkiewicz, David T. Levy, Rafael Meza, Nancy L. Fleischer
Correction to: Cook et al. Respiratory Research (2024) 25:13 https://doi.org/10.1186/s12931-023-02649-2 Following publication of the original article [1], the author’s name James H. Buszkiewicz was incorrectly written as James Buskiewicz. The author group has been updated above and the original article [1] has been corrected. Cook, S., Buskiewicz, J.H., Levy, D.T. et al. Association between cigar use
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Atorvastatin for reduction of 28-day mortality in severe and critical COVID-19 patients: a randomized controlled trial Respir. Res. (IF 5.8) Pub Date : 2024-02-22 Naglaa Hamdi Eltahan, Neamat Hamdy Elsawy, Kholoud M. Abdelaaty, Amal Salah Elhamaky, Ahmed H. Hassan, Moataz Maher Emara
COVID-19 is an abnormal host response to the SARS-CoV-2 infection, which is associated with endothelial dysfunction and multi-organ failure. Atorvastatin has been proposed to reduce COVID-19 severity and mortality in chronic and de-novo users. This randomized double-blind trial included 220 COVID-19 patients admitted to Mansoura University's isolation hospital in Egypt. One hundred and ten cases were
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Distinct impacts of radiological appearance on lymph node metastasis and prognosis based on solid size in clinical T1 non-small cell lung cancer Respir. Res. (IF 5.8) Pub Date : 2024-02-21 Zhihua Li, Cheng Pan, Wenzheng Xu, Chen Zhao, Xianglong Pan, Zhibo Wang, Weibing Wu, Liang Chen
Solid nodules (SN) had more aggressive features and a poorer prognosis than part-solid nodules (PSN). This study aimed to evaluate the specific impacts of nodule radiological appearance (SN vs. PSN) on lymph node metastasis and prognosis based on solid size in cT1 non-small cell lung cancer (NSCLC). Patients with cT1 NSCLC who underwent anatomical resection between 2010 and 2019 were retrospectively
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Impact of preexisting interstitial lung disease on mortality in COVID-19 patients from the early pandemic to the delta variant epidemic: a nationwide population-based study Respir. Res. (IF 5.8) Pub Date : 2024-02-21 Koichi Miyashita, Hironao Hozumi, Kazuki Furuhashi, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Toshiyuki Ojima, Takafumi Suda
COVID-19 patients with preexisting interstitial lung disease (ILD) were reported to have a high mortality rate; however, this was based on data from the early stages of the pandemic. It is uncertain how their mortality rates have changed with the emergence of new variants of concern as well as the development of COVID-19 vaccines and treatments. It is also unclear whether having ILD still poses a risk
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Causal relationships of metabolites with allergic diseases: a trans-ethnic Mendelian randomization study Respir. Res. (IF 5.8) Pub Date : 2024-02-20 Junhao Tu, Jinyang Wen, Qing Luo, Xin Li, Deyun Wang, Jing Ye
Allergic diseases exert a considerable impact on global health, thus necessitating investigations into their etiology and pathophysiology for devising effective prevention and treatment strategies. This study employs a Mendelian randomization (MR) analysis and meta-analysis to identify metabolite targets potentially associated with allergic diseases. A two-sample MR analysis was conducted to explore
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MiR-23a-5p alleviates chronic obstructive pulmonary disease through targeted regulation of RAGE-ROS pathway Respir. Res. (IF 5.8) Pub Date : 2024-02-20 Chenli Chang, Ke Huang, Xia Xu, Ruirui Duan, Tao Yu, Xu Chu, Chen Chen, Baicun Li, Ting Yang
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and represents the third leading cause of death worldwide. This study aimed to investigate miRNA regulation of Receptor for Advanced Glycation End-products (RAGE), a causal receptor in the pathogenesis of cigarette smoke (CS)-related COPD, to guide development of therapeutic strategies. RAGE expression was quantified in lung
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Assessing the acceptability and feasibility of remote spirometric monitoring for rural patients with interstitial lung disease: a multimethod approach Respir. Res. (IF 5.8) Pub Date : 2024-02-20 Ryan D. Boente, Sydney Schacht, Rebecca Borton, Joseph Vincent, Lilian Golzarri-Arroyo, Nicholas Rattray
Interstitial lung disease encompasses a group of rare lung conditions causing inflammation and scarring of lung tissue. The typical method of monitoring disease activity is through pulmonary function tests performed in a hospital setting. However, accessing care can be difficult for rural patients due to numerous barriers. This study assesses the feasibility and acceptability of home spirometry telemonitoring
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Association of blood cadmium concentration with chronic obstructive pulmonary disease progression: a prospective cohort study Respir. Res. (IF 5.8) Pub Date : 2024-02-17 Jing Sun, You-Peng Deng, Juan Xu, Feng-Min Zhu, Qi-Yuan He, Min-Min Tang, Ying Liu, Jin Yang, Hong-Yan Liu, Lin Fu, Hui Zhao
Prior studies in patients with chronic obstructive pulmonary disease (COPD) had indicated a potential correlation between cadmium (Cd) exposure and reduction in lung function. Nevertheless, the influence of Cd exposure on the progression of COPD remained unknown. Exploring the relationship between Cd exposure and the progression of COPD was the aim of this investigation. Stable COPD patients were enrolled
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Fine particulate matter 2.5 induces susceptibility to Pseudomonas aeruginosa infection via expansion of PD-L1high neutrophils in mice Respir. Res. (IF 5.8) Pub Date : 2024-02-14 Li Luo, Manling Jiang, Ying Xiong, Anying Xiong, Lei Zhang, Dehong Wu, Yao Liu, Qin Ran, Jiliu Liu, Yi Zhang, Jiahuan Li, Xiang He, Junyi Wang, Guoping Li
Exposure to PM2.5 has been implicated in a range of detrimental health effects, particularly affecting the respiratory system. However, the precise underlying mechanisms remain elusive. To address this objective, we collected ambient PM2.5 and administered intranasal challenges to mice, followed by single-cell RNA sequencing (scRNA-seq) to unravel the heterogeneity of neutrophils and unveil their gene
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A simple clinical risk score (ABCDMP) for predicting mortality in patients with AECOPD and cardiovascular diseases Respir. Res. (IF 5.8) Pub Date : 2024-02-10 Jiarui Zhang, Qun Yi, Chen Zhou, Yuanming Luo, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Xianhua Li, Xiufang Xie, Pinhua Pan, Mengqiu Yi, Lina Cheng, Hui Zhou, Liang Liu, Adila Aili, Yu Liu, Lige Peng, Jiaqi Pu, Haixia Zhou
The morbidity and mortality among hospital inpatients with AECOPD and CVDs remains unacceptably high. Currently, no risk score for predicting mortality has been specifically developed in patients with AECOPD and CVDs. We therefore aimed to derive and validate a simple clinical risk score to assess individuals’ risk of poor prognosis. We evaluated inpatients with AECOPD and CVDs in a prospective, noninterventional
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Blood MMP-9 measured at 2 years after lung transplantation as a prognostic biomarker of chronic lung allograft dysfunction Respir. Res. (IF 5.8) Pub Date : 2024-02-09 Adrien Tissot, Eugénie Durand, Thomas Goronflot, Benjamin Coiffard, Benjamin Renaud-Picard, Antoine Roux, Xavier Demant, Jean-François Mornex, Loïc Falque, Mathilde Salpin, Jérôme Le Pavec, Thomas Villeneuve, Véronique Boussaud, Christiane Knoop, Antoine Magnan, David Lair, Laureline Berthelot, Richard Danger, Sophie Brouard
Long-term outcomes of lung transplantation (LTx) remain hampered by chronic lung allograft dysfunction (CLAD). Matrix metalloproteinase 9 (MMP-9) is a secretory endopeptidase identified as a key mediator in fibrosis processes associated with CLAD. The objective of this study was to investigate whether plasma MMP9 levels may be prognostic of CLAD development. Participants were selected from the Cohort
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Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response Respir. Res. (IF 5.8) Pub Date : 2024-02-09 Caroline Sevoz-Couche, Maxime Patout, Beny Charbit, Thomas Similowski, Christian Straus
After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according
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Large airway T cells in adults with former bronchopulmonary dysplasia Respir. Res. (IF 5.8) Pub Date : 2024-02-09 Jing Gao, Petra Um-Bergström, Melvin Pourbazargan, Eva Berggren-Broström, ChuanXing Li, Heta Merikallio, Riitta Kaarteenaho, Nichole Stacey Reinke, Craig E Wheelock, Erik Melén, Lindén Anders, Åsa M Wheelock, Georgios Rassidakis, Cristian Ortiz-Villalon, Magnus Carl Sköld
Bronchopulmonary Dysplasia (BPD) in infants born prematurely is a risk factor for chronic airway obstruction later in life. The distribution of T cell subtypes in the large airways is largely unknown. To characterize cellular and T cell profiles in the large airways of young adults with a history of BPD. Forty-three young adults born prematurely (preterm (n = 20), BPD (n = 23)) and 45 full-term-born
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The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study Respir. Res. (IF 5.8) Pub Date : 2024-02-09 Tianqi Lu, Lies Lahousse, Sara Wijnant, Jinluan Chen, Guy G. Brusselle, Mandy van Hoek, M. Carola Zillikens
Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear. In the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV1 and lung diffusing capacity (DLCOc and DLCOc /alveolar volume [VA]) were
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The role of extracellular vesicles in COPD and potential clinical value Respir. Res. (IF 5.8) Pub Date : 2024-02-08 Shasha Liu, Xiaowu Tan, Sha Liu
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease and a major health burden worldwide. Extracellular vesicles (EVs) are nanosized vesicles which possess a lipid bilayer structure that are secreted by various cells. They contain a variety of bioactive substances, which can regulate various physiological and pathological processes and are closely related to the development
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The airway neuro-immune axis as a therapeutic target in allergic airway diseases Respir. Res. (IF 5.8) Pub Date : 2024-02-08 Wanhua Wu, Jianing Li, Su Chen, Suidong Ouyang
Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma and allergic rhinitis. The intimate spatial relationship between neurons and immune cells suggests that their interactions play a pivotal role in regulating allergic airway inflammation. Upon direct activation by allergens, neurons and immune cells engage
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Symptomatic post COVID patients have impaired alveolar capillary membrane function and high VE/VCO2 Respir. Res. (IF 5.8) Pub Date : 2024-02-08 Piergiuseppe Agostoni, Massimo Mapelli, Elisabetta Salvioni, Irene Mattavelli, Cristina Banfi, Alice Bonomi, Maria Luisa Biondi, Sara Rovai, Gloria Tamborini, Manuela Muratori, Sarah Ghulam Ali, Stefania Ghilardi, Fabiana De Martino, Carlo Vignati, Pietro Palermo, Paola Gugliandolo, Davide Elia, Federica Moscucci, Roberto Cassandro, Daniele Andreini, Elisabetta Mancini, Sergio Harari
Post COVID-19 syndrome is characterized by several cardiorespiratory symptoms but the origin of patients’ reported symptomatology is still unclear. Consecutive post COVID-19 patients were included. Patients underwent full clinical evaluation, symptoms dedicated questionnaires, blood tests, echocardiography, thoracic computer tomography (CT), spirometry including alveolar capillary membrane diffusion
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Association of musculoskeletal involvement with lung function and mortality in patients with idiopathic pulmonary fibrosis Respir. Res. (IF 5.8) Pub Date : 2024-02-08 Meenakshi Sridhar, Sandeep Bodduluri, Lanier O’Hare, Scott Blumhoff, Maria del Pilar Acosta Lara, Joao A. de Andrade, Young-Il Kim, Tracy Luckhardt, MerryLynn McDonald, Tejaswini Kulkarni
Idiopathic pulmonary fibrosis (IPF) is a progressive disease associated with high mortality. Low muscle mass, frailty and sarcopenia lead to functional impairment that negatively impact quality of life and survival but are not used in clinical practice. We aimed to determine the association of Fat-free mass index (FFMI) and frailty with lung function, exercise tolerance and survival in patients with
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Retraction Note: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury Respir. Res. (IF 5.8) Pub Date : 2024-02-07 Changping Gu, Mengjie Liu, Tao Zhao, Dong Wang, Yuelan Wang
The Editors-in-Chief retracted this article because of concerns regarding a number of figures presented in this work. These concerns call into question the integrity of the data and the article’s overall scientific soundness. An investigation conducted after its publication discovered instances of image overlap. The Editors-in-Chief therefore no longer have confidence in the integrity of the research
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Elevated pulmonary vascular resistance is associated with increased lung transplant waitlist mortality among patients with chronic obstructive pulmonary disease and pulmonary hypertension: a retrospective cohort analysis Respir. Res. (IF 5.8) Pub Date : 2024-02-07 Shameek K. Gayen, Mary Zulty, Gerard J. Criner
The latest European Society of Cardiology and European Respiratory Society guidelines have changed the definition of both pre-capillary pulmonary hypertension (PH) and severe PH in chronic lung disease. The clinical significance of these new criteria are unclear among patients with chronic obstructive pulmonary disease (COPD)-PH. We aim to examine the clinical significance of the new PH definitions
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Interstitial lung abnormality evaluated by an automated quantification system: prevalence and progression rate Respir. Res. (IF 5.8) Pub Date : 2024-02-06 Ju Hyun Oh, Grace Hyun J. Kim, Jin Woo Song
Despite the importance of recognizing interstitial lung abnormalities, screening methods using computer-based quantitative analysis are not well developed, and studies on the subject with an Asian population are rare. We aimed to identify the prevalence and progression rate of interstitial lung abnormality evaluated by an automated quantification system in the Korean population. A total of 2,890 healthy
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Circular RNAs and their roles in idiopathic pulmonary fibrosis Respir. Res. (IF 5.8) Pub Date : 2024-02-06 Akshaya Surendran, Chaoqun Huang, Lin Liu
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. Circular RNAs (circRNAs) have emerged as a novel class of non-coding RNAs with diverse functions in cellular processes. This review paper aims to explore the potential involvement of circRNAs in the pathogenesis of IPF and their diagnostic and therapeutic implications. We begin by providing an
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Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Xiu Yu, Lifei Li, Bicheng Cai, Wei Zhang, Quan Liu, Nan Li, Xing Shi, Li Yu, Rongchang Chen, Chen Qiu
Asthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with abnormal responses of various cell types in the lung. The specific interactions between immune and stromal cells, crucial for asthma pathogenesis, remain unclear. This study aims to determine the key cell types and their pathological mechanisms in asthma through single-cell
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In vitro toxicological evaluation of aerosols generated by a 4th generation vaping device using nicotine salts in an air-liquid interface system Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Clément Mercier, Jérémie Pourchez, Lara Leclerc, Valérie Forest
Electronic cigarettes (EC) have gained popularity, especially among young people, with the introduction of fourth-generation devices based on e-liquids containing nicotine salts that promise a smoother vaping experience than freebase nicotine. However, the toxicological effects of nicotine salts are still largely unknown, and the chemical diversity of e-liquids limits the comparison between different
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Comprehensive analysis reveals the prognostic and immunogenic characteristics of DNA methylation regulators in lung adenocarcinoma Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Jing Huang, Chujian Huang, Can Huang, Zichang Xiang, Yao Ni, Jian Zeng, Songhua Cai
DNA methylation regulators (DMRs) play a key role in DNA methylation, thus mediating tumor occurrence, metastasis, and immunomodulation. However, the effects of DMRs on clinical outcomes and immunotherapy response remain unexplored in lung adenocarcinoma (LUAD). In this study, eight LUAD cohorts and one immunotherapeutic cohort of lung cancer were utilized. We constructed a DNA methylation regulators-related
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Impact of ambient temperature on respiratory disease: a case-crossover study in Seoul Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Hyewon Lee, Hee-Young Yoon
Respiratory diseases contribute to global morbidity and mortality, and temperature is a significant factor. We investigated the association between ambient temperature and emergency department (ED) visits for various respiratory diseases in Seoul, South Korea. Using data from the National Emergency Department Information System (2008–2017), we analysed 1,616,644 ED visits for respiratory diseases,
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Dynamics of host immune responses and a potential function of Trem2hi interstitial macrophages in Pneumocystis pneumonia Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Hu-Qin Yang, Han Sun, Kang Li, Ming-Ming Shao, Kan Zhai, Zhao-Hui Tong
Pneumocystis pneumonia (PCP) is a life-threatening opportunistic fungal infection with a high mortality rate in immunocompromised patients, ranging from 20 to 80%. However, current understanding of the variation in host immune response against Pneumocystis across different timepoints is limited. In this study, we conducted a time-resolved single-cell RNA sequencing analysis of CD45+ cells sorted from
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Viral coinfection in hospitalized patients during the COVID-19 pandemic in Southern Brazil: a retrospective cohort study Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Jaqueline Rhoden, Andressa Taíz Hoffmann, Janaína Franciele Stein, Bruna Seixas da Rocha, Vinícius Monteagudo de Barros, Eduardo Viegas da Silva, Juliane Deise Fleck, Caroline Rigotto
Since the worldwide spread of SARS-CoV-2, different strategies have been followed to combat the pandemic and limit virus transmission. In the meantime, other respiratory viruses continued to circulate, though at decreased rates. This study was conducted between June and July 2022, in a hospital in the metropolitan region of Rio Grande do Sul state, in the southernmost state of Brazil. The 337 hospitalized
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Low-frequency ultrasound for pulmonary hypertension therapy Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Vytautas Ostasevicius, Vytautas Jurenas, Mantas Venslauskas, Laura Kizauskiene, Vilma Zigmantaite, Edgaras Stankevicius, Algimantas Bubulis, Joris Vezys, Sandra Mikuckyte
Currently, there are no reliable clinical tools that allow non-invasive therapeutic support for patients with pulmonary arterial hypertension. This study aims to propose a low-frequency ultrasound device for pulmonary hypertension therapy and to demonstrate its potential. A novel low-frequency ultrasound transducer has been developed. Due to its structural properties, it is excited by higher vibrational
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Role of multidrug-resistant bacteria in weaning from invasive mechanical ventilation Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Julia D. Michels-Zetsche, Vicky Gassmann, Jasmin K. Jasuja, Benjamin Neetz, Philipp Höger, Jan Meis, Simone Britsch, Urte Sommerwerck, Sebastian Fähndrich, Florian Bornitz, Michael M. Müller, Felix J.F. Herth, Franziska C. Trudzinski
Although multidrug-resistant bacteria (MDR) are common in patients undergoing prolonged weaning, there is little data on their impact on weaning and patient outcomes. This is a retrospective analysis of consecutive patients who underwent prolonged weaning and were at a university weaning centre from January 2018 to December 2020. The influence of MDR colonisation and infection on weaning success (category
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Clinical application of bronchoalveolar lavage fluid metagenomics next-generation sequencing in cancer patients with severe pneumonia Respir. Res. (IF 5.8) Pub Date : 2024-02-05 Chao Wang, Xiaojuan Yin, Wenqing Ma, Li Zhao, Xuhong Wu, Nan Ma, Yuepeng Cao, Quanli Zhang, Shuliang Ma, Lin Xu, Xuerong Wang
Metagenomic next-generation sequencing (mNGS), as an emerging technique for pathogen detection, has been widely used in clinic. However, reports on the application of mNGS in cancer patients with severe pneumonia remain limited. This study aims to evaluate the diagnostic performance of bronchoalveolar lavage fluid (BALF) mNGS in cancer patients complicated with severe pneumonia. A total of 62 cancer