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Metabolomic characterization of COVID-19 survivors in Jilin province Respir. Res. (IF 4.7) Pub Date : 2024-09-19 Panyang Xu, Lei Zeng, Chunyu Wang, Jiatong Chai, Junguo Yin, Jiancheng Xu
The COVID-19 pandemic has escalated into a severe global public health crisis, with persistent sequelae observed in some patients post-discharge. However, metabolomic characterization of the reconvalescent remains unclear. In this study, serum and urine samples from COVID-19 survivors (n = 16) and healthy subjects (n = 16) underwent testing via the non-targeted metabolomics approach using UPLC-MS/MS
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An algorithm for discontinuing mechanical ventilation in boys with x-linked myotubular myopathy after positive response to gene therapy: the ASPIRO experience Respir. Res. (IF 4.7) Pub Date : 2024-09-16 Robert J. Graham, Reshma Amin, Nadir Demirel, Lisa Edel, Charlotte Lilien, Victoria MacBean, Gerrard F. Rafferty, Hemant Sawnani, Carola Schön, Barbara K. Smith, Faiza Syed, Micaela Sarazen, Suyash Prasad, Salvador Rico, Geovanny F. Perez
X-linked myotubular myopathy (XLMTM) is a rare, life-threatening congenital myopathy. Most (80%) children with XLMTM have profound muscle weakness and hypotonia at birth resulting in severe respiratory insufficiency, the inability to sit up, stand or walk, and early mortality. At birth, 85–90% of children with XLMTM require mechanical ventilation, with more than half requiring invasive ventilator support
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Serum tumor markers: potential indicators for occult lymph node metastasis in clinical T1 − 2N0M0 small cell lung cancer patients Respir. Res. (IF 4.7) Pub Date : 2024-09-16 Xu Jiang, Meng-Wen Liu, Lei Miao, Jiu-Ming Jiang, Lin Yang, Meng Li, Li Zhang
In their letter-to-the-editor entitled “Letter to the Editor: Incidence rate of occult lymph node metastasis in clinical T1 − 2N0M0 small cell lung cancer patients and radiomic prediction based on contrast-enhanced CT imaging: a multicenter study”, Prof. Chen et al. provided insightful comments and suggestions on our original study. We appreciate the authors’ feedback and have conducted a preliminary
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Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study Respir. Res. (IF 4.7) Pub Date : 2024-09-16 Yazun Liu, Hao Zhang, Jinrong Wang, Yuling Han, Chunhong Pan, Wenhui Jiang, Chunyan Ma, Yongsheng Shi, Chunmei Jia, Yuehua Zhang, Ming Li, Fei Wang, Yanyan Yu, Yong Feng, Li Liu, Aihong Liu, Qiaoling Zhang, Zhen Long, Fuli Dai, Yanli Zhang, Minghong Ji, Dongjun Ma
The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6–18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions. We measured FeNO50 levels in 5949 healthy Chinese children and adolescents, FeNO200 and
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Effect of low climate impact vs. high climate impact inhalers for patients with asthma and COPD-a nationwide cohort analysis Respir. Res. (IF 4.7) Pub Date : 2024-09-12 Barbara Bonnesen, Josefin Eklöf, Tor Biering-Sørensen, Daniel Modin, Marc Miravitlles, Alexander G. Mathioudakis, Pradeesh Sivapalan, Jens-Ulrik Staehr Jensen
Chronic obstructive pulmonary disease (COPD) and asthma can be treated with inhaled corticosteroids (ICS) delivered by low climate impact inhalers (dry powder inhalers) or high climate impact inhalers (pressurized metered-dose inhalers containing potent greenhouse gasses). ICS delivered with greenhouse gasses is prescribed ubiquitously and frequent despite limited evidence of superior effect. Our aim
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Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary Respir. Res. (IF 4.7) Pub Date : 2024-09-11 Wenying Lu, Rebekka Aarsand, Kerstin Schotte, Jing Han, Elizaveta Lebedeva, Elena Tsoy, Nino Maglakelidze, Joan B Soriano, Werner Bill, David M G Halpin, M. Patricia Rivera, Kwun M Fong, Hasmeena Kathuria, Arzu Yorgancıoğlu, Monika Gappa, David CL Lam, Sarah Rylance, Sukhwinder Singh Sohal
The WHO recently published a Tobacco Knowledge Summary (TKS) synthesizing current evidence on tobacco and COPD, aiming to raise awareness among a broad audience of health care professionals. Furthermore, it can be used as an advocacy tool in the fight for tobacco control and prevention of tobacco-related disease. This article builds on the evidence presented in the TKS, with a greater level of detail
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Novel approach to exploring protease activity and targets in HIV-associated obstructive lung disease using combined proteomic-peptidomic analysis Respir. Res. (IF 4.7) Pub Date : 2024-09-10 Sarah Samorodnitsky, Monica Kruk, Eric F. Lock, Ken M. Kunisaki, Alison Morris, Janice M. Leung, Danielle Weise, Subina Mehta, Laurie L. Parker, Pratik D. Jagtap, Timothy J. Griffin, Chris H. Wendt
Obstructive lung disease (OLD) is increasingly prevalent among persons living with HIV (PLWH). However, the role of proteases in HIV-associated OLD remains unclear. We combined proteomics and peptidomics to comprehensively characterize protease activities. We combined mass spectrometry (MS) analysis on bronchoalveolar lavage fluid (BALF) peptides and proteins from PLWH with OLD (n = 25) and without
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Using machine learning for early detection of chronic obstructive pulmonary disease: a narrative review Respir. Res. (IF 4.7) Pub Date : 2024-09-09 Xueting Shen, Huanbing Liu
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease and ranks third in global mortality rates, imposing a significant burden on patients and society. This review looks at recent research, both domestically and abroad, on the application of machine learning (ML) for early COPD screening. The review discusses the practical application, key optimization points, and prospects
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The association between cumulative exposure to PM2.5 and DNA methylation measured using methyl-capture sequencing among COPD patients Respir. Res. (IF 4.7) Pub Date : 2024-09-09 Hyun Woo Ji, Jieun Kang, Hwan-Cheol Kim, Junghee Jung, Seon-Jin Lee, Ji Ye Jung, Sei Won Lee
Particulate matter with a diameter of < 2.5 μm (PM2.5) influences gene regulation via DNA methylation; however, its precise mechanism of action remains unclear. Thus, this study aimed to examine the connection between personal PM2.5 exposure and DNA methylation in CpG islands as well as explore the associated gene pathways. A total of 95 male patients with chronic obstructive pulmonary disease (COPD)
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Is YouTube a sufficient source of information on Sarcoidosis? Respir. Res. (IF 4.7) Pub Date : 2024-09-09 Katharina Buschulte, Sarah El-Hadi, Philipp Höger, Claudia Ganter, Marlies Wijsenbeek, Nicolas Kahn, Katharina Kriegsmann, Gillian C. Goobie, Christopher J. Ryerson, Markus Polke, Franziska Trudzinski, Michael Kreuter
The internet is a common source of health information for patients and caregivers. To date, content and information quality of YouTube videos on sarcoidosis has not been studied. The aim of our study was to investigate the content and quality of information on sarcoidosis provided by YouTube videos. Of the first 200 results under the search term “sarcoidosis,” all English-language videos with content
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Risk of incident chronic obstructive pulmonary disease during longitudinal follow-up in patients with nontuberculous mycobacterial pulmonary disease Respir. Res. (IF 4.7) Pub Date : 2024-09-09 Bo-Guen Kim, Sun Hye Shin, Sun-Kyung Lee, Sang-Heon Kim, Hyun Lee
The Global Initiative for Chronic Obstructive Lung Disease 2023 revision proposed that chronic obstructive pulmonary disease (COPD) has various etiologies including infections (COPD-I), such as tuberculosis and human immunodeficiency virus. While nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis share similar clinical manifestations, research on COPD development during
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Characteristics of lung resistance and elastance associated with tracheal stenosis and intrapulmonary airway narrowing in ex vivo sheep lungs Respir. Res. (IF 4.7) Pub Date : 2024-09-09 Yuto Yasuda, Geoffrey N. Maksym, Lu Wang, Pasquale Chitano, Chun Y. Seow
Understanding the characteristics of pulmonary resistance and elastance in relation to the location of airway narrowing, e.g., tracheal stenosis vs. intrapulmonary airway obstruction, will help us understand lung function characteristics and mechanisms related to different airway diseases. In this study, we used ex vivo sheep lungs as a model to measure lung resistance and elastance across a range
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Mask side-effects are related to gender in long-term CPAP: results from the InterfaceVent real-life study Respir. Res. (IF 4.7) Pub Date : 2024-09-06 Celia Vidal, Fanny Bertelli, Jean-Pierre Mallet, Raphael Gilson, Jean-Christian Borel, Frédéric Gagnadoux, Arnaud Bourdin, Nicolas Molinari, Dany Jaffuel
Over the past three decades, our understanding of sleep apnea in women has advanced, revealing disparities in pathophysiology, diagnosis, and treatment compared to men. However, no real-life study to date has explored the relationship between mask-related side effects (MRSEs) and gender in the context of long-term CPAP. The InterfaceVent-CPAP study is a prospective real-life cross-sectional study conducted
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Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia Respir. Res. (IF 4.7) Pub Date : 2024-09-03 Kenichiro Kikuchi, Satoshi Kazuma, Michiaki Yamakage
Vascular endothelial damage is involved in the development and exacerbation of ventilator-induced lung injury (VILI). Pulmonary endothelial glycocalyx and neutrophil extracellular traps (NETs) are endothelial protective and damaging factors, respectively; however, their dynamics in VILI and the effects of recombinant thrombomodulin and antithrombin on these dynamics remain unclear. We hypothesized
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CT-based whole lung radiomics nomogram for identification of PRISm from non-COPD subjects Respir. Res. (IF 4.7) Pub Date : 2024-09-03 TaoHu Zhou, Yu Guan, XiaoQing Lin, XiuXiu Zhou, Liang Mao, YanQing Ma, Bing Fan, Jie Li, ShiYuan Liu, Li Fan
Preserved Ratio Impaired Spirometry (PRISm) is considered to be a precursor of chronic obstructive pulmonary disease. Radiomics nomogram can effectively identify the PRISm subjects from non-COPD subjects, especially when during large-scale CT lung cancer screening. Totally 1481 participants (864, 370 and 247 in training, internal validation, and external validation cohorts, respectively) were included
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Unraveling the Mfn2-Warburg effect nexus: a therapeutic strategy to combat pulmonary arterial hypertension arising from catch-up growth after IUGR Respir. Res. (IF 4.7) Pub Date : 2024-09-02 Lingling Yan, Xiaofei Luo, Chengcheng Hang, YuWang, Ziming Zhang, Shanshan Xu, Lizhong Du
The interplay between intrauterine and early postnatal environments has been associated with an increased risk of cardiovascular diseases in adulthood, including pulmonary arterial hypertension (PAH). While emerging evidence highlights the crucial role of mitochondrial pathology in PAH, the specific mechanisms driving fetal-originated PAH remain elusive. To elucidate the role of mitochondrial dynamics
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Employing a synergistic bioinformatics and machine learning framework to elucidate biomarkers associating asthma with pyrimidine metabolism genes Respir. Res. (IF 4.7) Pub Date : 2024-08-31 Dihui Zhang, Xiaowei Pu, Man Zheng, Guanghui Li, Jia Chen
Asthma, a prevalent chronic inflammatory disorder, is shaped by a multifaceted interplay between genetic susceptibilities and environmental exposures. Despite strides in deciphering its pathophysiological landscape, the intricate molecular underpinnings of asthma remain elusive. The focus has increasingly shifted toward the metabolic aberrations accompanying asthma, particularly within the domain of
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Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell–expressed developmentally down-regulated gene 4-Like Respir. Res. (IF 4.7) Pub Date : 2024-08-29 Rui Wang, Rui Wang, Siqi Zhou, Tianya Liu, Jingjing Dang, Qianmin Chen, Jingyu Chen, Zhiping Wang
In this study, we investigated whether neural precursor cell–expressed developmentally down-regulated gene 4-like (NEDD4L) is the E3 enzyme of angiotensin-converting enzyme 2 (ACE2) and whether NEDD4L degrades ACE2 via ubiquitination, leading to the progression of pulmonary arterial hypertension (PAH). Bioinformatic analyses were used to explore the E3 ligase that ubiquitinates ACE2. Cultured pulmonary
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The burden of cough in idiopathic pulmonary fibrosis and other interstitial lung diseases: a systematic evidence synthesis Respir. Res. (IF 4.7) Pub Date : 2024-08-27 Rhiannon Green, Michael Baldwin, Nick Pooley, Kate Misso, Maureen PMH Rutten-van Mölken, Nina Patel, Marlies S. Wijsenbeek
Cough remains a persistent symptom in patients with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILDs). To inform future research, treatment and care models, we conducted the first systematic synthesis of evidence on its associated burden. A literature search was performed for articles published between January 2010 and October 2023 using databases including Embase, MEDLINE
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Cobalt exposure and pulmonary function reduction in chronic obstructive pulmonary disease patients: the mediating role of club cell secretory protein Respir. Res. (IF 4.7) Pub Date : 2024-08-24 Fei Tang, Hong-Yan Liu, Qi-Yuan He, Ying Liu, Li-Ping Lv, Jun Fei, Lin Fu
Cobalt (Co) is a metal which is widely used in the industrial production. The previous studies found the toxic effects of environmental Co exposure on multiple organs. However, the correlation of blood Co concentration with lung function was inconsistent in patients with chronic obstructive pulmonary disease (COPD). All 771 stable COPD patients were recruited. Peripheral blood and clinical information
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Surgery versus intrapleural fibrinolysis for management of complicated pleural infections: a systematic review and meta-analysis Respir. Res. (IF 4.7) Pub Date : 2024-08-24 Jaewon Chang, Ben Indja, Jesse King, Stephanie Chan, Campbell D. Flynn
Complicated pleural infection comprises of complex effusions and empyema. When tube thoracostomy is ineffective, treatment options include surgical drainage, deloculation and decortication or intrapleural fibrinolysis. We performed a systematic review and meta-analysis to examine which technique is superior in treating complicated pleural infections. PubMed, MEDLINE and EMBASE databases were searched
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Transcriptomic analysis reveals distinct effects of cigarette smoke on murine airspace and bone-marrow derived macrophages Respir. Res. (IF 4.7) Pub Date : 2024-08-24 Lynne Faherty, William Z. Zhang, Mays M. Salih, Elektra K. Robinson, Elizabeth Perez, Kihwan Kim, Susan Carpenter, Suzanne M. Cloonan
Chronic obstructive pulmonary disease (COPD) is an inflammatory airway disease characterized by emphysema and chronic bronchitis and a leading cause of mortality worldwide. COPD is commonly associated with several comorbid diseases which contribute to exacerbated patient outcomes. Cigarette smoke (CS) is the most prominent risk factor for COPD development and progression and is known to be detrimental
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Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells Respir. Res. (IF 4.7) Pub Date : 2024-08-22 Ju Chang-Chien, Jing-Long Huang, Hui-Ju Tsai, Shih-Ling Wang, Ming-Ling Kuo, Tsung-Chieh Yao
Mitochondria is prone to oxidative damage by endogenous and exogenous sources of free radicals, including particulate matter (PM). Given the role of mitochondria in inflammatory disorders, such as asthma and chronic obstructive pulmonary disease, we hypothesized that supplementation of vitamin D may play a protective role in PM-induced mitochondrial oxidative damages of human bronchial epithelial BEAS-2B
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Impact of radiomics features, pulmonary emphysema score and muscle mass on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies Respir. Res. (IF 4.7) Pub Date : 2024-08-22 Jakob Leonhardi, Ulrike Dahms, Benedikt Schnarkowski, Manuel Florian Struck, Anne-Kathrin Höhn, Sebastian Krämer, Sebastian Ebel, Gordian Prasse, Armin Frille, Timm Denecke, Hans-Jonas Meyer
Iatrogenic pneumothorax is a relevant complication of computed tomography (CT)-guided percutaneous lung biopsy. The aim of the present study was to analyze the prognostic significance of texture analysis, emphysema score and muscle mass derived from CT-imaging to predict postinterventional pneumothorax after CT-guided lung biopsy. Consecutive patients undergoing CT-guided percutaneous lung biopsy between
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Artificial intelligence in COPD CT images: identification, staging, and quantitation Respir. Res. (IF 4.7) Pub Date : 2024-08-22 Yanan Wu, Shuyue Xia, Zhenyu Liang, Rongchang Chen, Shouliang Qi
Chronic obstructive pulmonary disease (COPD) stands as a significant global health challenge, with its intricate pathophysiological manifestations often demanding advanced diagnostic strategies. The recent applications of artificial intelligence (AI) within the realm of medical imaging, especially in computed tomography, present a promising avenue for transformative changes in COPD diagnosis and management
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Assessment and monitoring of lung disease in patients with severe alpha 1 antitrypsin deficiency: a european delphi consensus of the EARCO group Respir. Res. (IF 4.7) Pub Date : 2024-08-19 Marc Miravitlles, Alice M. Turner, Maria Sucena, Jean-François Mornex, Timm Greulich, Marion Wencker, N. Gerard McElvaney
Currently, there is conflicting information and guidance on the effective management of Alpha 1 Antitrypsin Deficiency (AATD). Establishing a consensus of assessment and disease management specific to AATD is important for achieving a standardized treatment pathway and for improving patient outcomes. Here, we aim to utilize the Delphi method to establish a European consensus for the assessment and
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Distinctive field effects of smoking and lung cancer case-control status on bronchial basal cell growth and signaling Respir. Res. (IF 4.7) Pub Date : 2024-08-19 Olsida Zefi, Spencer Waldman, Ava Marsh, Miao Kevin Shi, Yosef Sonbolian, Batbayar Khulan, Taha Siddiqui, Aditi Desai, Dhruv Patel, Aham Okorozo, Samer Khader, Jay Dobkin, Ali Sadoughi, Chirag Shah, Simon Spivack, Yakov Peter
Basal cells (BCs) are bronchial progenitor/stem cells that can regenerate injured airway that, in smokers, may undergo malignant transformation. As a model for early stages of lung carcinogenesis, we set out to characterize cytologically normal BC outgrowths from never-smokers and ever-smokers without cancers (controls), as well as from the normal epithelial “field” of ever-smokers with anatomically
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Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension Respir. Res. (IF 4.7) Pub Date : 2024-08-19 Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu Zhou
Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev in the treatment of PH is unknown. We used hypoxia-induced pulmonary artery smooth muscle cells (PASMCs) to establish a PH cell model. A number of cell biology methods were performed to assay alterations
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Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD. Respir. Res. (IF 4.7) Pub Date : 2024-08-19 Simonetta Baraldo, Matteo Bonato, Sebastiano Cassia, Paolo Casolari, Laura De Ferrari, Mariaenrica Tiné, Federico Baraldi, Tommaso Bigoni, Anna Maria Riccio, Fulvio Braido, Marina Saetta, Alberto Papi, Marco Contoli
Chronic obstructive pulmonary disease (COPD) is a frequent cause of morbidity and mortality. Dysregulated and enhanced immune-inflammatory responses have been described in COPD. Recent data showed impaired immune responses and, in particular, of interferon (IFNs) signaling pathway in these patients. To evaluate in peripheral lung of COPD patients, the expression of some of the less investigated key
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Pulmonary adaptation to repeated poly(I:C) exposure is impaired in asthmatic mice: an observational study Respir. Res. (IF 4.7) Pub Date : 2024-08-19 Benoit Allard, Olga Ousova, Zhanna Savitskaya, Hannah Levardon, Elise Maurat, Marilyne Campagnac, Thomas Trian, Patrick Berger
While asthma exacerbations remain a major challenge in patient management, few animal models exist to explore the underlying mechanisms. Here, we established an animal model of asthma that can be used to study pathophysiological mechanisms and therapeutic strategies on asthma exacerbation. Female BALB/c mice were sensitized and exposed to PBS or Dermatophagoides pteronyssinus (DerP) extract for 11
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The role and mechanism of thrombospondin-4 in pulmonary arterial hypertension associated with congenital heart disease Respir. Res. (IF 4.7) Pub Date : 2024-08-17 Haowei Zeng, Beidi Lan, Bingyi Li, Hang Xie, Enfa Zhao, Xiaoqin Liu, Xiaoyi Xue, Jingyan Sun, Linjie Su, Yushun Zhang
Due to a special hemodynamic feature, pulmonary vascular disease in pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) has two stages: reversible and irreversible. So far, the mechanism involved in the transition from reversible to irreversible stage is elusive. Moreover, no recognized and reliable assessments to distinguish these two stages are available. Furthermore
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Epidemiology, ventilation management and outcomes of COVID–19 ARDS patients versus patients with ARDS due to pneumonia in the Pre–COVID era Respir. Res. (IF 4.7) Pub Date : 2024-08-17 Fleur–Stefanie L. I. M. van der Ven, Siebe G. Blok, Luciano C. Azevedo, Giacomo Bellani, Michela Botta, Elisa Estenssoro, Eddy Fan, Juliana Carvalho Ferreira, John G. Laffey, Ignacio Martin–Loeches, Ana Motos, Tai Pham, Oscar Peñuelas, Antonio Pesenti, Luigi Pisani, Ary Serpa Neto, Marcus J. Schultz, Antoni Torres, Anissa M. Tsonas, Frederique Paulus, David M. P. van Meenen
Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS also exist in COVID–ARDS. Individual patient data analysis of COVID–ARDS and CLASSIC–ARDS patients in six observational studies of ventilation, four in the COVID–19 pandemic and two
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Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation Respir. Res. (IF 4.7) Pub Date : 2024-08-17 Suidong Ouyang, Peishan Lu, Jianing Li, Hua Jin, Wanhua Wu, Renxing Luo, Bin Wang, Xueqin Huang, Xinlong Lian, Gonghua Huang
Tea polyphenols (TPs), prominent constituents of green tea, possess remarkable antioxidant and anti-inflammatory properties. However, their therapeutic potential is limited due to low absorption and poor bioavailability. To address this limitation and enhance their efficacy, we developed a biomimetic nanoplatform by coating platelet membrane (PM) onto poly-lactic-co-glycolic acid (PLGA) nanoparticles
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PARK2 as a susceptibility factor for nontuberculous mycobacterial pulmonary disease Respir. Res. (IF 4.7) Pub Date : 2024-08-14 Youngmok Park, Ji Won Hong, Eunsol Ahn, Heon Yung Gee, Young Ae Kang
The genetic signatures associated with the susceptibility to nontuberculous mycobacterial pulmonary disease (NTM-PD) are still unknown. In this study, we performed RNA sequencing to explore gene expression profiles and represent characteristic factor in NTM-PD. Peripheral blood samples were collected from patients with NTM-PD and healthy individuals (controls). Differentially expressed genes (DEGs)
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Integrated omics characterization reveals reduced cancer indicators and elevated inflammatory factors after thermal ablation in non-small cell lung cancer patients Respir. Res. (IF 4.7) Pub Date : 2024-08-14 Xinglu Zhang, Shuai Shao, Nan Song, Baolu Yang, Fengjiao Liu, Zhaohui Tong, Feng Wang, Jieqiong Li
Thermal ablation is a minimally invasive treatment for non-small cell lung cancer (NSCLC). Aside from causing an immediate direct tumour cell injury, the effects of thermal ablation on the internal microenvironment are unknown. This study aimed to investigate the effects of thermal ablation on the plasma internal environment in patients with NSCLC. 128 plasma samples were collected from 48 NSCLC (pre
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The clinical impacts of lung microbiome in bronchiectasis with fixed airflow obstruction: a prospective cohort study Respir. Res. (IF 4.7) Pub Date : 2024-08-14 Yen-Fu Chen, Hsin-Han Hou, Ning Chien, Kai-Zen Lu, Chieh-Hua Lin, Yu-Chieh Liao, Kuo-Lung Lor, Jung-Yien Chien, Chung-Ming Chen, Chung-Yu Chen, Shih-Lung Cheng, Hao-Chien Wang, Po-Ren Hsueh, Chong-Jen Yu
Airflow obstruction is a hallmark of disease severity and prognosis in bronchiectasis. The relationship between lung microbiota, airway inflammation, and outcomes in bronchiectasis with fixed airflow obstruction (FAO) remains unclear. This study explores these interactions in bronchiectasis patients, with and without FAO, and compares them to those diagnosed with chronic obstructive pulmonary disease
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Proportion of confluent B-Lines predicts respiratory support in term infants shortly after birth Respir. Res. (IF 4.7) Pub Date : 2024-08-13 Xinao Lin, Hehua Zhang, Xuefeng Wang, Ruijie Zhang, Lu Zhang, Xueqin You, Lingling Xiao, Chuyan Wu, Feng Jiang, Jimei Wang
To develop and evaluate the predictive value of a simplified lung ultrasound (LUS) method for forecasting respiratory support in term infants. This observational, prospective, diagnostic accuracy study was conducted in a tertiary academic hospital between June and December 2023. A total of 361 neonates underwent LUS examination within 1 h of birth. The proportion of each LUS sign was utilized to predict
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Small airway dysfunction links asthma exacerbations with asthma control and health-related quality of life Respir. Res. (IF 4.7) Pub Date : 2024-08-12 Fan Gao, Jiahui Lei, He Zhu, Limin Zhao
Small airway dysfunction not only affects asthma control, but also has adverse effects on the psychological and/or social activities of asthma patients. However, few long-term observational studies have explored the complex relationship between small airway dysfunction and asthma control and health-related quality of life in patients with asthma exacerbations. The study recruited 223 patients with
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Longitudinal association of exclusive and dual use of cigarettes and cigars with asthma exacerbation among US adults: a cohort study Respir. Res. (IF 4.7) Pub Date : 2024-08-10 Akash Patel, James H. Buszkiewicz, Steven Cook, Douglas A. Arenberg, Nancy L. Fleischer
Cigar use among adults in the United States has remained relatively stable in the past decade and occupies a growing part of the tobacco marketplace as cigarette use has declined. While studies have established the detrimental respiratory health effects of cigarette use, the effects of cigar use need further characterization. In this study, we evaluate the prospective association between cigar use
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Distinct enterotypes and dysbiosis: unraveling gut microbiota in pulmonary and critical care medicine inpatients Respir. Res. (IF 4.7) Pub Date : 2024-08-10 Naijian Li, Guiyan Tan, Zhiling Xie, Weixin Chen, Zhaowei Yang, Zhang Wang, Sha Liu, Mengzhang He
The gut-lung axis, pivotal for respiratory health, is inadequately explored in pulmonary and critical care medicine (PCCM) inpatients. Examining PCCM inpatients from three medical university-affiliated hospitals, we conducted 16S ribosomal RNA sequencing on stool samples (inpatients, n = 374; healthy controls, n = 105). We conducted statistical analyses to examine the gut microbiota composition in
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Therapeutic efficacy of thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles on Escherichia coli-induced acute lung injury in mice Respir. Res. (IF 4.7) Pub Date : 2024-08-07 Yuna Bang, Sein Hwang, Young Eun Kim, Dong Kyung Sung, Misun Yang, So Yoon Ahn, Se In Sung, Kyeung Min Joo, Yun Sil Chang
Acute lung injury (ALI) following pneumonia involves uncontrolled inflammation and tissue injury, leading to high mortality. We previously confirmed the significantly increased cargo content and extracellular vesicle (EV) production in thrombin-preconditioned human mesenchymal stromal cells (thMSCs) compared to those in naïve and other preconditioning methods. This study aimed to investigate the therapeutic
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The cGAS-STING pathway in COPD: targeting its role and therapeutic potential Respir. Res. (IF 4.7) Pub Date : 2024-08-07 Kexin Liao, Fengshuo Wang, Chenhao Xia, Ze Xu, Sen Zhong, Wenqi Bi, Jingjing Ruan
Chronic obstructive pulmonary disease(COPD) is a gradually worsening and fatal heterogeneous lung disease characterized by airflow limitation and increasingly decline in lung function. Currently, it is one of the leading causes of death worldwide. The consistent feature of COPD is airway inflammation. Several inflammatory factors are known to be involved in COPD pathogenesis; however, anti-inflammatory
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Mendelian randomization study on causal association of TEF and circadian rhythm with pulmonary arterial hypertension Respir. Res. (IF 4.7) Pub Date : 2024-08-07 Dandan Chen, Qi Jin, Lifan Yang, Xiaochun Zhang, Mingfei Li, Lei Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge, Lihua Guan
Previous research has revealed the potential impact of circadian rhythms on pulmonary diseases; however, the connection between circadian rhythm-associated Thyrotroph Embryonic Factor (TEF) and Pulmonary Arterial Hypertension (PAH) remains unclear. We aim to assess the genetic causal relationship between TEF and PAH by utilizing two sets of genetic instrumental variables (IV) and publicly available
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Therapeutic effect of long-acting muscarinic antagonist for treating uncontrolled asthma assessed using impulse oscillometry Respir. Res. (IF 4.7) Pub Date : 2024-08-07 Hiroyuki Sugawara, Atsushi Saito, Saori Yokoyama, Hirofumi Chiba
In recent years, the incorporation of LAMAs into asthma therapy has been expected to enhance symptom control. However, a significant number of patients with asthma continue to experience poorly managed symptoms. There have been limited investigations on LAMA-induced airway alterations in asthma treatment employing IOS. In this study, we administered a LAMA to patients with poorly controlled asthma
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TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation Respir. Res. (IF 4.7) Pub Date : 2024-08-07 Jiaojiao Zhu, Xingkun Ao, Yuhao Liu, Shenghui Zhou, Yifan Hou, Ziyan Yan, Lin Zhou, Huixi Chen, Ping Wang, Xinxin Liang, Dafei Xie, Shanshan Gao, Ping-Kun Zhou, Yongqing Gu
Although recent studies provide mechanistic understanding to the pathogenesis of radiation induced lung injury (RILI), rare therapeutics show definitive promise for treating this disease. Type II alveolar epithelial cells (AECII) injury in various manner results in an inflammation response to initiate RILI. Here, we reported that radiation (IR) up-regulated the TNKS1BP1, causing progressive accumulation
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Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans Respir. Res. (IF 4.7) Pub Date : 2024-08-07 Alessandro Gobbi, Andrea Antonelli, Raffaele Dellaca, Giulia M. Pellegrino, Riccardo Pellegrino, Jeffrey J. Fredberg, Julian Solway, Vito Brusasco
Increasing functional residual capacity (FRC) or tidal volume (VT) reduces airway resistance and attenuates the response to bronchoconstrictor stimuli in animals and humans. What is unknown is which one of the above mechanisms is more effective in modulating airway caliber and whether their combination yields additive or synergistic effects. To address this question, we investigated the effects of
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Benefits of budesonide/glycopyrronium/formoterol fumarate dihydrate on lung function and exacerbations of COPD: a post-hoc analysis of the KRONOS study by blood eosinophil level and exacerbation history Respir. Res. (IF 4.7) Pub Date : 2024-08-05 Shigeo Muro, Tomotaka Kawayama, Hisatoshi Sugiura, Munehiro Seki, Elizabeth A. Duncan, Karin Bowen, Jonathan Marshall, Ayman Megally, Mehul Patel
Japanese guidelines recommend triple inhaled corticosteroid (ICS)/long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) therapy in patients with chronic obstructive pulmonary disease (COPD) and no concurrent asthma diagnosis who experience frequent exacerbations and have blood eosinophil (EOS) count ≥ 300 cells/mm3, and in patients with COPD and asthma with continuing/worsening symptoms
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Identification of TFRC as a biomarker for pulmonary arterial hypertension based on bioinformatics and experimental verification Respir. Res. (IF 4.7) Pub Date : 2024-08-03 Chuang Yang, Yi-Hang Liu, Hai-Kuo Zheng
Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there is a paucity of studies that reflect the available biomarkers from separate gene expression profiles in PAH. The GSE131793 and GSE113439 datasets were combined for subsequent analyses, and batch effects were removed. Bioinformatic analysis was then performed to identify differentially expressed
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G12/13 signaling in asthma Respir. Res. (IF 4.7) Pub Date : 2024-08-02 Elizabeth L. McDuffie, Reynold A. Panettieri, Charles P. Scott
Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for asthma. Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium sensitization, which inhibits myosin light chain phosphatase. The mechanism through which pro-contractile stimuli activate calcium sensitization is poorly understood. Our review of the literature
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Exploring the mechanism of Lianhuaqingwen (LHQW) in treating chronic bronchitis based on network pharmacology and experimental validation Respir. Res. (IF 4.7) Pub Date : 2024-08-02 Shaozhang Lin, Shuan Wang, Qingping Jiang, Shaoyan Liu, Shujing Liu, Tonghui Cai
Lianhuaqingwen (LHQW) has been used in the treatment of chronic bronchitis, but the precise mechanism through which LHQW exhibits its anti-inflammatory effects in this context is not yet fully understood. The aim of this study was to investigate the active ingredients and signaling pathways responsible for LHQW's effectiveness in managing chronic bronchitis. The research leveraged the TCMSP database
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Antifibrotics and mortality in idiopathic pulmonary fibrosis: external validity and avoidance of immortal time bias Respir. Res. (IF 4.7) Pub Date : 2024-07-31 Hironao Hozumi, Koichi Miyashita, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Takafumi Suda
Pooled analyses of previous randomized controlled trials reported that antifibrotics improved survival in patients with idiopathic pulmonary fibrosis (IPF), but the results were only based on short-term outcome data from selected patients who met strict criteria. Observational studies/meta-analyses also suggested that antifibrotics improve survival, but these studies failed to control for immortal
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Effects of malnutrition on disease severity and adverse outcomes in idiopathic pulmonary arterial hypertension: a retrospective cohort study Respir. Res. (IF 4.7) Pub Date : 2024-07-30 Sicheng Zhang, Sicong Li, Luyang Gao, Qing Zhao, Tao Yang, Qixian Zeng, Zhihua Huang, Xin Li, Anqi Duan, Yijia Wang, Zhihui Zhao, Qin Luo, Zhihong Liu
Malnutrition is common in patients with chronic cardiovascular disease and is associated with significantly higher all-cause mortality. Approximately one-third of patients with heart failure are malnourished. However, the relationship between malnutrition and idiopathic pulmonary arterial hypertension (IPAH) remains unclear. This study aimed to clarify the prognostic value of malnutrition in patients
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Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3 Respir. Res. (IF 4.7) Pub Date : 2024-07-30 Guiyin Zhu, Haiyang Yu, Tian Peng, Kun Yang, Xue Xu, Wen Gu
Acute lung injury (ALI) is characterized by an unregulated inflammatory reaction, often leading to severe morbidity and ultimately death. Excessive inflammation caused by M1 macrophage polarization and pyroptosis has been revealed to have a critical role in ALI. Recent study suggests that glycolytic reprogramming is important in the regulation of macrophage polarization and pyroptosis. However, the
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The role of extracellular traps released by neutrophils, eosinophils, and macrophages in asthma Respir. Res. (IF 4.7) Pub Date : 2024-07-30 Wei Gu, Chunli Huang, Gongqi Chen, Weiqiang Kong, Lu Zhao, Huiru Jie, Guohua Zhen
Extracellular traps (ETs) are a specialized form of innate immune defense in which leukocytes release ETs composed of chromatin and active proteins to eliminate pathogenic microorganisms. In addition to the anti-infection effect of ETs, researchers have also discovered their involvement in the pathogenesis of inflammatory disease, tumors, autoimmune disease, and allergic disease. Asthma is a chronic
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Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells Respir. Res. (IF 4.7) Pub Date : 2024-07-30 Iain R. Konigsberg, Nancy W. Lin, Shu-Yi Liao, Cuining Liu, Kristyn MacPhail, Margaret M. Mroz, Elizabeth Davidson, Clara I. Restrepo, Sunita Sharma, Li Li, Lisa A. Maier, Ivana V. Yang
Sarcoidosis is a heterogeneous granulomatous disease with no accurate biomarkers of disease progression. Therefore, we profiled and integrated the DNA methylome, mRNAs, and microRNAs to identify molecular changes associated with sarcoidosis and disease progression that might illuminate underlying mechanisms of disease and potential biomarkers. Bronchoalveolar lavage cells from 64 sarcoidosis subjects
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Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats Respir. Res. (IF 4.7) Pub Date : 2024-07-30 Qian Jiang, Qifeng Yang, Chenting Zhang, Chi Hou, Wei Hong, Min Du, Xiaoqian Shan, Xuanyi Li, Dansha Zhou, Dongmei Wen, Yuanhui Xiong, Kai Yang, Ziying Lin, Jingjing Song, Zhanjie Mo, Huazhuo Feng, Yue Xing, Xin Fu, Chunli Liu, Fang Peng, Liling Wu, Bing Li, Wenju Lu, Jason X.-J. Yuan, Jian Wang, Yuqin Chen
Chronic kidney disease (CKD) is a significant risk factor for pulmonary hypertension (PH), a complication that adversely affects patient prognosis. However, the mechanisms underlying this association remain poorly understood. A major obstacle to progress in this field is the lack of a reliable animal model replicating CKD-PH. This study aimed to establish a stable rat model of CKD-PH. We employed a
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Novel hypoxia-induced HIF-1αactivation in asthma pathogenesis Respir. Res. (IF 4.7) Pub Date : 2024-07-25 Mengzhi Wan, Qi Yu, Fei Xu, Lu Xia You, Xiao Liang, Kang kang Ren, Jing Zhou
Asthma’s complexity, marked by airway inflammation and remodeling, is influenced by hypoxic conditions. This study focuses on the role of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) and P53 ubiquitination in asthma exacerbation. High-throughput sequencing and bioinformatics were used to identify genes associated with asthma progression, with an emphasis on GO and KEGG pathway analyses. An asthma mouse
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Machine learning for accurate detection of small airway dysfunction-related respiratory changes: an observational study Respir. Res. (IF 4.7) Pub Date : 2024-07-24 Wen-Jing Xu, Wen-Yi Shang, Jia-Ming Feng, Xin-Yue Song, Liang-Yuan Li, Xin-Peng Xie, Yan-Mei Wang, Bin-Miao Liang
The use of machine learning(ML) methods would improve the diagnosis of small airway dysfunction(SAD) in subjects with chronic respiratory symptoms and preserved pulmonary function(PPF). This paper evaluated the performance of several ML algorithms associated with the impulse oscillometry(IOS) analysis to aid in the diagnostic of respiratory changes in SAD. We also find out the best configuration for
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Blood lipid profiles as a prognostic biomarker in idiopathic pulmonary fibrosis Respir. Res. (IF 4.7) Pub Date : 2024-07-18 Ju Hyun Oh, Ganghee Chae, Jin Woo Song
Dysregulation of lipid metabolism is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the association between the blood lipid profiles and the prognosis of IPF is not well defined. We aimed to identify the impacts of lipid profiles on prognosis in patients with IPF. Clinical data of 371 patients with IPF (145 and 226 in the derivation and validation cohorts, respectively)
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Regulation of myofibroblast dedifferentiation in pulmonary fibrosis Respir. Res. (IF 4.7) Pub Date : 2024-07-18 Xuetao Ju, Kai Wang, Congjian Wang, Chenxi Zeng, Yi Wang, Jun Yu
Idiopathic pulmonary fibrosis is a lethal, progressive, and irreversible condition that has become a significant focus of medical research due to its increasing incidence. This rising trend presents substantial challenges for patients, healthcare providers, and researchers. Despite the escalating burden of pulmonary fibrosis, the available therapeutic options remain limited. Currently, the United States