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The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-09-19 Svenja Offer, Sebastiano Di Bucchianico, Hendryk Czech, Michal Pardo, Jana Pantzke, Christoph Bisig, Eric Schneider, Stefanie Bauer, Elias J. Zimmermann, Sebastian Oeder, Elena Hartner, Thomas Gröger, Rasha Alsaleh, Christian Kersch, Till Ziehm, Thorsten Hohaus, Christopher P. Rüger, Simone Schmitz-Spanke, Jürgen Schnelle-Kreis, Martin Sklorz, Astrid Kiendler-Scharr, Yinon Rudich, Ralf Zimmermann
The formation of secondary organic aerosols (SOA) by atmospheric oxidation reactions substantially contributes to the burden of fine particulate matter (PM2.5), which has been associated with adverse health effects (e.g., cardiovascular diseases). However, the molecular and cellular effects of atmospheric aging on aerosol toxicity have not been fully elucidated, especially in model systems that enable
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Genome-wide DNA methylation sequencing reveals the involvement of ferroptosis in hepatotoxicity induced by dietary exposure to food-grade titanium dioxide Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-09-18 Jiaxin Shang, Jun Yan, He Lou, Rongshang Shou, Yingqi Zhan, Xiaoyan Lu, Xiaohui Fan
Following the announcement by the European Food Safety Authority that the food additive titanium dioxide (E 171) is unsafe for human consumption, and the subsequent ban by the European Commission, concerns have intensified over the potential risks E 171 poses to human vital organs. The liver is the main organ for food-grade nanoparticle metabolism. It is increasingly being found that epigenetic changes
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Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78/IRE1α/JNK axis induced apoptosis and endoplasmic reticulum stress Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-09-11 Jun Bai, Yuzeng Wang, Siwei Deng, Ying Yang, Sheng Chen, Zhenlong Wu
Microplastics (MPs), a brand-new class of worldwide environmental pollutant, have received a lot of attention. MPs are consumed by both humans and animals through water, food chain and other ways, which may cause potential health risks. However, the effects of MPs on embryonic development, especially placental function, and its related mechanisms still need to be further studied. We investigated the
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Spatial regulation of NMN supplementation on brain lipid metabolism upon subacute and sub-chronic PM exposure in C57BL/6 mice Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-09-09 Yue Jiang, Fang Li, Lizhu Ye, Rui Zhang, Shen Chen, Hui Peng, Haiyan Zhang, Daochuan Li, Liping Chen, Xiaowen Zeng, Guanghui Dong, Wei Xu, Chunyang Liao, Rong Zhang, Qian Luo, Wen Chen
Atmospheric particulate matter (PM) exposure-induced neuroinflammation is critical in mediating nervous system impairment. However, effective intervention is yet to be developed. In this study, we examine the effect of β-nicotinamide mononucleotide (NMN) supplementation on nervous system damage upon PM exposure and the mechanism of spatial regulation of lipid metabolism. 120 C57BL/6 male mice were
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Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-08-21 Yunxiao Yang, Feng Zhang, Zhili Jiang, Zhiyong Du, Sheng Liu, Ming Zhang, Yanyan Jin, Yanwen Qin, Xiubin Yang, Chenggang Wang, Hai Gao
Microplastics, widely present in the environment, are implicated in disease pathogenesis through oxidative stress and immune modulation. Prevailing research, primarily based on animal and cell studies, falls short in elucidating microplastics' impact on human cardiovascular health. This cross-sectional study detected blood microplastic concentrations in patients presenting with chest pain using pyrolysis–gas
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Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-08-14 Ilse Gosens, Jordi Minnema, A. John F. Boere, Evert Duistermaat, Paul Fokkens, Janja Vidmar, Katrin Löschner, Bas Bokkers, Anna L. Costa, Ruud J.B. Peters, Christiaan Delmaar, Flemming R. Cassee
Physiologically based kinetic models facilitate the safety assessment of inhaled engineered nanomaterials (ENMs). To develop these models, high quality datasets on well-characterized ENMs are needed. However, there are at present, several data gaps in the systemic availability of poorly soluble particles after inhalation. The aim of the present study was therefore to acquire two comparable datasets
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Multimodal pulmonary clearance kinetics of carbon black nanoparticles deposited in the lungs of rats: the role of alveolar macrophages Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-08-12 Dong-Keun Lee, Gyuri Kim, Muthuchamy Maruthupandy, Kyuhong Lee, Wan-Seob Cho
Alveolar macrophages (AMs) have been predicted to affect the pulmonary clearance of nanomaterials; however, their qualitative and quantitative roles are poorly understood. In this study, carbon black nanoparticles (CBNPs) were instilled into the lungs of Wistar rats at 30, 100, and 300 µg/rat. The concentrations of particles in organs, including the lung, lung-associated lymph nodes (LALN), liver,
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Correction: Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-08-09 Gowsinth Gunasingam, Ruiwen He, Patricia Taladriz-Blanco, Sandor Balog, Alke Petri-Fink, Barbara Rothen-Rutishauser
Correction: Particle and Fibre Toxicology (2024) 21:26 https://doi.org/10.1186/s12989-024-00585-7 Following publication of the original article [1], the authors reported that the figure captions are mismatched in Figs. 3, 4 and 5. The correct figures and captions have been provided in this Correction. Fig. 3 Visualization and quantification of translocated DEPs into the basal fraction across porous
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Protective effect of Cordycepin on blood-testis barrier against pre-puberty polystyrene nanoplastics exposure in male rats Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-08-09 Ying Hu, Shuyi Jiang, Qiang Zhang, Wenjie Zhou, Jinhong Liang, Ying Xu, Wenhui Su
Plastic pollution is an emerging environmental issue, with microplastics and nanoplastics raising health concerns due to bioaccumulation. This work explored the impact of polystyrene nanoparticle (PS-NPs) exposure during prepuberty on male reproductive function post maturation in rats. Rats were gavaged with PS-NPs (80 nm) at 0, 3, 6, 12 mg/kg/day from postnatal day 21 to 95. PS-NPs accumulated in
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Investigation of pulmonary inflammatory responses following intratracheal instillation of and inhalation exposure to polypropylene microplastics Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-08-06 Taisuke Tomonaga, Hidenori Higashi, Hiroto Izumi, Chinatsu Nishida, Naoki Kawai, Kazuma Sato, Toshiki Morimoto, Yasuyuki Higashi, Kazuhiro Yatera, Yasuo Morimoto
Microplastics have been detected in the atmosphere as well as in the ocean, and there is concern about their biological effects in the lungs. We conducted a short-term inhalation exposure and intratracheal instillation using rats to evaluate lung disorders related to microplastics. We conducted an inhalation exposure of polypropylene fine powder at a low concentration of 2 mg/m3 and a high concentration
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Worse pulmonary function in association with cumulative exposure to nanomaterials. Hints of a mediation effect via pulmonary inflammation Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-06-28 Giulia Squillacioti, Thomas Charreau, Pascal Wild, Valeria Bellisario, Federica Ghelli, Roberto Bono, Enrico Bergamaschi, Giacomo Garzaro, Irina Guseva Canu
Today, nanomaterials are broadly used in a wide range of industrial applications. Such large utilization and the limited knowledge on to the possible health effects have raised concerns about potential consequences on human health and safety, beyond the environmental burden. Given that inhalation is the main exposure route, workers exposed to nanomaterials might be at risk of occurrence of respiratory
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Systemic immunological responses are dependent on sex and ovarian hormone presence following acute inhaled woodsmoke exposure Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-05-27 Kartika Wardhani, Sydnee Yazzie, Charlotte McVeigh, Onamma Edeh, Martha Grimes, Quiteria Jacquez, Connor Dixson, Edward Barr, Rui Liu, Alicia M. Bolt, Changjian Feng, Katherine E. Zychowski
Rural regions of the western United States have experienced a noticeable surge in both the frequency and severity of acute wildfire events, which brings significant challenges to both public safety and environmental conservation efforts, with impacts felt globally. Identifying factors contributing to immune dysfunction, including endocrinological phenotypes, is essential to understanding how hormones
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Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-05-22 Gowsinth Gunasingam, Ruiwen HE, Patricia Taladriz-Blanco, Sandor Balog, Alke Petri-Fink, Barbara Rothen-Rutishauser
During inhalation, airborne particles such as particulate matter ≤ 2.5 μm (PM2.5), can deposit and accumulate on the alveolar epithelial tissue. In vivo studies have shown that fractions of PM2.5 can cross the alveolar epithelium to blood circulation, reaching secondary organs beyond the lungs. However, approaches to quantify the translocation of particles across the alveolar epithelium in vivo and
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Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-05-17 Kirsty Meldrum, Stephen J. Evans, Michael J. Burgum, Shareen H. Doak, Martin J. D. Clift
Exposure to indoor air pollutants (IAP) has increased recently, with people spending more time indoors (i.e. homes, offices, schools and transportation). Increased exposures of IAP on a healthy population are poorly understood, and those with allergic respiratory conditions even less so. The objective of this study, therefore, was to implement a well-characterised in vitro model of the human alveolar
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Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-05-17 Tizia Thoma, Lan Ma-Hock, Steffen Schneider, Naveed Honarvar, Silke Treumann, Sibylle Groeters, Volker Strauss, Heike Marxfeld, Dorothee Funk-Weyer, Svenja Seiffert, Wendel Wohlleben, Martina Dammann, Karin Wiench, Noömi Lombaert, Christine Spirlet, Marie Vasquez, Nicole Dewhurst, Robert Landsiedel
Significant variations exist in the forms of ZnO, making it impossible to test all forms in in vivo inhalation studies. Hence, grouping and read-across is a common approach under REACH to evaluate the toxicological profile of familiar substances. The objective of this paper is to investigate the potential role of dissolution, size, or coating in grouping ZnO (nano)forms for the purpose of hazard assessment
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Synthetic silica fibers of different length, diameter and shape: synthesis and interaction with rat (NR8383) and human (THP-1) macrophages in vitro, including chemotaxis and gene expression profile Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-05-11 Nataniel Białas, Nina Rosenkranz, Daniel Gilbert Weber, Kathrin Kostka, Georg Johnen, Aileen Winter, Alexander Brik, Kateryna Loza, Katja Szafranski, Thomas Brüning, Jürgen Bünger, Götz Westphal, Matthias Epple
Inhalation of biopersistent fibers like asbestos can cause strong chronic inflammatory effects, often resulting in fibrosis or even cancer. The interplay between fiber shape, fiber size and the resulting biological effects is still poorly understood due to the lack of reference materials. We investigated how length, diameter, aspect ratio, and shape of synthetic silica fibers influence inflammatory
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Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-04-29 Leisha Martin, Kayla Simpson, Molly Brzezinski, John Watt, Wei Xu
Plastic accumulation in the environment is rapidly increasing, and nanoplastics (NP), byproducts of environmental weathering of bulk plastic waste, pose a significant public health risk. Particles may enter the human body through many possible routes such as ingestion, inhalation, and skin absorption. However, studies on NP penetration and accumulation in human skin are limited. Loss or reduction of
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Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-04-24 Yunyi Wang, Ke Xu, Xiao Gao, Zhaolan Wei, Qi Han, Shuxin Wang, Wanting Du, Mingqing Chen
Increasing attention is being paid to the environmental and health impacts of nanoplastics (NPs) pollution. Exposure to nanoplastics (NPs) with different charges and functional groups may have different adverse effects after ingestion by organisms, yet the potential ramifications on mammalian blood glucose levels, and the risk of diabetes remain unexplored. Mice were exposed to PS-NPs/COOH/NH2 at a
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Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-04-12 Junjie Fan, Li Liu, Yongling Lu, Qian Chen, Shijun Fan, Yongjun Yang, Yupeng Long, Xin Liu
The global use of plastic materials has undergone rapid expansion, resulting in the substantial generation of degraded and synthetic microplastics and nanoplastics (MNPs), which have the potential to impose significant environmental burdens and cause harmful effects on living organisms. Despite this, the detrimental impacts of MNPs exposure towards host cells and tissues have not been thoroughly characterized
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The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-04-10 Min Chen, Siyuan Chen, Xinyu Wang, Zongjian Ye, Kehan Liu, Yijing Qian, Meng Tang, Tianshu Wu
Recently, carbon quantum dots (CQDs) have been widely used in various fields, especially in the diagnosis and therapy of neurological disorders, due to their excellent prospects. However, the associated inevitable exposure of CQDs to the environment and the public could have serious severe consequences limiting their safe application and sustainable development. In this study, we found that intranasal
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Micro- and nanoplastics concepts for particle and fibre toxicologists Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-04-02 Stephanie Wright, Flemming R. Cassee, Aaron Erdely, Matthew J. Campen
Micro- and nanoplastic particles (MNP) are omnipresent as either pollution or intentionally used in consumer products, released from packaging or even food. There is an exponential increase in the production of plastics. With the realization of bioaccumulation in humans, toxicity research is quickly expanding. There is a rapid increase in the number of papers published on the potential implications
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Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-04-01 Xueyan Li, Hailin Xu, Xinying Zhao, Yan Li, Songqing Lv, Wei Zhou, Ji Wang, Zhiwei Sun, Yanbo Li, Caixia Guo
Amorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a newly defined form of programmed cell death that is implicated in myocardial diseases. Nevertheless, its role in the adverse cardiac effects of SiNPs has not been described. We first reported the induction of cardiomyocyte ferroptosis by SiNPs
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In vitro inflammation and toxicity assessment of pre- and post-incinerated organomodified nanoclays to macrophages using high-throughput screening approaches Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-21 Todd A. Stueckle, Jake Jensen, Jayme P. Coyle, Raymond Derk, Alixandra Wagner, Cerasela Zoica Dinu, Tiffany G. Kornberg, Sherri A. Friend, Alan Dozier, Sushant Agarwal, Rakesh K. Gupta, Liying W. Rojanasakul
Organomodified nanoclays (ONC), two-dimensional montmorillonite with organic coatings, are increasingly used to improve nanocomposite properties. However, little is known about pulmonary health risks along the nanoclay life cycle even with increased evidence of airborne particulate exposures in occupational environments. Recently, oropharyngeal aspiration exposure to pre- and post-incinerated ONC in
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Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-11 Eva C. M. Vitucci, Alysha E. Simmons, Elizabeth M. Martin, Shaun D. McCullough
Particulate matter 2.5 (PM2.5) deposition in the lung’s alveolar capillary region (ACR) is significantly associated with respiratory disease development, yet the molecular mechanisms are not completely understood. Adverse responses that promote respiratory disease development involve orchestrated, intercellular signaling between multiple cell types within the ACR. We investigated the molecular mechanisms
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Monitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air–liquid interface Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-08 Aiman Abzhanova, Jon Berntsen, Edward R. Pennington, Lisa Dailey, Syed Masood, Ingrid George, Nina Warren, Joseph Martin, Michael D. Hays, Andrew J. Ghio, Jason P. Weinstein, Yong Ho Kim, Earl Puckett, James M. Samet
Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity of woodsmoke, a complex mixture of gases, volatile organic compounds, and particulate matter, is commonly studied in vitro using isolated exposures of conventionally cultured lung cells to either resuspended particulate matter or organic
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Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-07 Shukun Wan, Xiaoqing Wang, Weina Chen, Manli Wang, Jingsong Zhao, Zhongyan Xu, Rong Wang, Chenyang Mi, Zhaodian Zheng, Huidong Zhang
With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution and their adverse health effects have attracted global attention. MPs have been detected out in human body and both MPs and NPs showed female reproductive toxicological effects in animal models. Miscarriage (abnormal early embryo loss), accounting for 15-25% pregnant women worldwide, greatly
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Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-07 Xiaofeng Qin, Zhiyuan Niu, Hui Chen, Yongbin Hu
Chronic inflammation and fibrosis are characteristics of silicosis, and the inflammatory mediators involved in silicosis have not been fully elucidated. Recently, macrophage-derived exosomes have been reported to be inflammatory modulators, but their role in silicosis has not been explored. The purpose of the present study was to investigate the role of macrophage-derived exosomal high mobility group
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Correction: Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-06 Caroline Carlé, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanuel Mas, Marie Carriere, Ziad Al Nabhani, Frédérick Barreau
Correction: Particle and Fibre Toxicology (2023) 20:45https://doi.org/10.1186/s12989-023-00555-5 Following publication of the original article [1], the authors reported some spelling and bibliograph errors. Below is a table of corrections which have been implemented in the original article. The original article [1] has been corrected. Section Originally published text Corrected text Abstract Perinatal
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Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-03-01 Laura Morin, Valérie Lecureur, Alain Lescoat
Crystalline silica (cSiO2) is a mineral found in rocks; workers from the construction or denim industries are particularly exposed to cSiO2 through inhalation. cSiO2 inhalation increases the risk of silicosis and systemic autoimmune diseases. Inhaled cSiO2 microparticles can reach the alveoli where they induce inflammation, cell death, auto-immunity and fibrosis but the specific molecular pathways
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Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-02-28 Bour-Jr Wang, Yu-Ying Chen, Hui-Hsuan Chang, Rong-Jane Chen, Ying-Jan Wang, Yu-Hsuan Lee
Zinc oxide nanoparticles (ZnONPs) are common materials used in skin-related cosmetics and sunscreen products due to their whitening and strong UV light absorption properties. Although the protective effects of ZnONPs against UV light in intact skin have been well demonstrated, the effects of using ZnONPs on damaged or sunburned skin are still unclear. In this study, we aimed to reveal the detailed
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Differential pulmonary toxicity and autoantibody formation in genetically distinct mouse strains following combined exposure to silica and diesel exhaust particles Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-02-27 Lisa MF Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen AJ Vanoirbeek, Kenneth Michael Pollard, Manosij Ghosh, Peter HM Hoet
Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects. This study investigates the separate and combined
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Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-02-17 Denisa Lizonova, Amogh Nagarkar, Philip Demokritou, Georgios A. Kelesidis
Airborne environmental and engineered nanoparticles (NPs) are inhaled and deposited in the respiratory system. The inhaled dose of such NPs and their deposition location in the lung determines their impact on health. When calculating NP deposition using particle inhalation models, a common approach is to use the bulk material density, ρb, rather than the effective density, ρeff. This neglects though
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Particulate matter from car exhaust alters function of human iPSC-derived microglia Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-02-15 Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm, Paula Korhonen
Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer’s disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral
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Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-02-06 Ismena Gałęcka, Natalia Szyryńska, Jarosław Całka
Currently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on the animal and human organism remains not fully understood. The digestive tract is one of the first barriers between pathogens and xenobiotics and a living organism. Its proper functioning is extremely important in order to maintain homeostasis. The aim of this study
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The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-02-04 Hugo Brouwer, Mojtaba Porbahaie, Sjef Boeren, Mathias Busch, Hans Bouwmeester
Micro- and nanoplastics (MNPs) represent one of the most widespread environmental pollutants of the twenty-first century to which all humans are orally exposed. Upon ingestion, MNPs pass harsh biochemical conditions within the gastrointestinal tract, causing a unique protein corona on the MNP surface. Little is known about the digestion-associated protein corona and its impact on the cellular uptake
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Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-01-31 Stella Marie Reamon-Buettner, Susanne Rittinghausen, Annika Klauke, Andreas Hiemisch, Christina Ziemann
Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. However, studies in rodents have shown that certain multiwalled carbon nanotubes (MWCNTs) can also induce malignant mesothelioma. The exact mechanisms are still unclear. To gain further insights into molecular pathways leading to carcinogenesis, we
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Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-01-31 Joycie Shanmugiah, Javeria Zaheer, Changkeun Im, Choong Mo Kang, Jin Su Kim
Recent studies showed the presence of microplastic in human lungs. There remains an unmet need to identify the biodistribution of microplastic after inhalation. In this study, we traced the biodistribution of inhaled micro-sized polystyrene (mPS) and/or nano-sized PS (nPS) using 64Cu with PET in mice. We used 0.2–0.3-µm sized mPS and 20-nm sized nPS throughout. 64Cu-DOTA-mPS, 64Cu-DOTA-nPS and/or 64CuCl2
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ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials Part. Fibre Toxicol. (IF 7.2) Pub Date : 2024-01-15 Xinpei Lin, Wei Wang, Xiangyu Chang, Cheng Chen, Zhenkun Guo, Guangxia Yu, Wenya Shao, Siying Wu, Qunwei Zhang, Fuli Zheng, Huangyuan Li
As the demand and application of engineered nanomaterials have increased, their potential toxicity to the central nervous system has drawn increasing attention. Tunneling nanotubes (TNTs) are novel cell–cell communication that plays a crucial role in pathology and physiology. However, the relationship between TNTs and nanomaterials neurotoxicity remains unclear. Here, three types of commonly used engineered
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Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood–retinal barrier damages and disease susceptibilities Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-12-18 Yuzhou Gu, Feiyin Sheng, Mengqin Gao, Li Zhang, Shengjie Hao, Shuying Chen, Rongrong Chen, Yili Xu, Di Wu, Yu Han, Lu Chen, Ye Liu, Bing Lu, Wei Zhao, Xiaoming Lou, Zhijian Chen, Peng Li, Xiaofeng Wang, Ke Yao, Qiuli Fu
The association between air pollution and retinal diseases such as age-related macular degeneration (AMD) has been demonstrated, but the pathogenic correlation is unknown. Damage to the outer blood–retinal barrier (oBRB), which consists of the retinal pigment epithelium (RPE) and choriocapillaris, is crucial in the development of fundus diseases. To describe the effects of airborne fine particulate
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Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-12-18 Juan Ma, Yin Wan, Lingmin Song, Luchen Wang, Huimei Wang, Yingzhi Li, Danfei Huang
Nanoplastics (NPs) are omnipresent in our lives as a new type of pollution with a tiny size. It can enter organisms from the environment, accumulate in the body, and be passed down the food chain. Inflammatory bowel disease (IBD) is a nonspecific intestinal inflammatory disease that is recurrent and prevalent in the population. Given that the intestinal features of colitis may affect the behavior and
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Maternal exposure to nano-titanium dioxide impedes fetal development via endothelial-to-mesenchymal transition in the placental labyrinth in mice Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-12-11 Xianjie Li, Yinger Luo, Di Ji, Zhuyi Zhang, Shili Luo, Ya Ma, Wulan Cao, Chunwei Cao, Phei Er Saw, Hui Chen, Yanhong Wei
Extensive production and usage of commercially available products containing TiO2 NPs have led to accumulation in the human body. The deposition of TiO2 NPs has even been detected in the human placenta, which raises concerns regarding fetal health. Previous studies regarding developmental toxicity have frequently focused on TiO2 NPs < 50 nm, whereas the potential adverse effects of large-sized TiO2
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Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-12-08 M. Friberg, A. F. Behndig, J. A. Bosson, Ala Muala, S. Barath, R. Dove, D. Glencross, F. J. Kelly, A. Blomberg, I. S. Mudway, T. Sandström, J. Pourazar
Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increased production of inflammatory mediators. There remains uncertainty regarding the impact of DE on endogenous antioxidant and xenobiotic defences, mediated by nuclear factor erythroid
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Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-11-29 Tianyi Zhang, Sheng Yang, Yiling Ge, Xin Wan, Yuxin Zhu, Fei Yang, Jie Li, Saisai Gong, Yanping Cheng, Chengyu Hu, Zaozao Chen, Lihong Yin, Yuepu Pu, Geyu Liang
Nanoplastics (NPs) could be released into environment through the degradation of plastic products, and their content in the air cannot be ignored. To date, no studies have focused on the cardiac injury effects and underlying mechanisms induced by respiratory exposure to NPs. Here, we systematically investigated the cardiotoxicity of 40 nm polystyrene nanoplastics (PS-NPs) in mice exposed via inhalation
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Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-11-23 Caroline Carlé, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanuel Mas, Marie Carriere, Ziad Al Nabhani, Frédérick Barreau
Perinatal exposure to titanium dioxide (TiO2), as a foodborne particle, may influence the intestinal barrier function and the susceptibility to develop inflammatory bowel disease (IBD) later in life. Here, we investigate the impact of perinatal foodborne TiO2 exposure on the intestinal mucosal function and the susceptibility to develop IBD-associated colitis. Pregnant and lactating mother mice were
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Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-11-22 Yuji Huang, Boxuan Liang, Zhiming Li, Yizhou Zhong, Bo Wang, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Weicui Min, Xiliang Yan, Yanhong Deng, Yu Feng, Ruobing Bai, Bingchi Fan, Xingfen Yang, Zhenlie Huang
Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, and have raised concerns regarding their potential risks to human health, particularly neurotoxicity. This study aimed to investigate the deleterious effects of polystyrene nanoplastics (PS-NPs, 50 nm) and understand their mechanisms in inducing Parkinson's disease (PD)-like neurodegeneration, along
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Food-grade titanium dioxide and zinc oxide nanoparticles induce toxicity and cardiac damage after oral exposure in rats Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-11-17 Manuel Alejandro Herrera-Rodríguez, María del Pilar Ramos-Godinez, Agustina Cano-Martínez, Francisco Correa Segura, Angélica Ruiz-Ramírez, Natalia Pavón, Elizabeth Lira-Silva, Rocío Bautista-Pérez, Rosina Sánchez Thomas, Norma Laura Delgado-Buenrostro, Yolanda Irasema Chirino, Rebeca López-Marure
Metallic nanoparticles (NPs) are widely used as food additives for human consumption. NPs reach the bloodstream given their small size, getting in contact with all body organs and cells. NPs have adverse effects on the respiratory and intestinal tract; however, few studies have focused on the toxic consequences of orally ingested metallic NPs on the cardiovascular system. Here, the effects of two food-grade
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Heterogeneous deposition of regular and mentholated little cigar smoke in the lungs of Sprague-Dawley rats Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-11-06 Kaisen Lin, Christopher Wallis, Emily M. Wong, Patricia Edwards, Austin Cole, Laura Van Winkle, Anthony S. Wexler
Quantifying the dose and distribution of tobacco smoke in the respiratory system is critical for understanding its toxicity, addiction potential, and health impacts. Epidemiologic studies indicate that the incidence of lung tumors varies across different lung regions, suggesting there may be a heterogeneous deposition of smoke particles leading to greater health risks in specific regions. Despite this
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High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-11-02 Yiqun Mo, Luke Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan, Qunwei Zhang
Epidemiological studies have demonstrated that individuals with preexisting conditions, including diabetes mellitus (DM), are more susceptible to air pollution. However, the underlying mechanisms remain unclear. In this study, we proposed that a high glucose setting enhances ambient fine particulate matter (PM2.5)-induced macrophage activation and secretion of the proinflammatory cytokine, IL-1β, through
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An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-10-24 Jenny Rissler, Madeleine Peterson Sjögren, Julia Linell, Amalia Larsson Hurtig, Per Wollmer, Jakob Löndahl
The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm. We designed an experimental set-up to measure
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Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-10-20 Gerrit Bredeck, Jochen Dobner, Burkhard Stahlmecke, Khanneh Wadinga Fomba, Hartmut Herrmann, Andrea Rossi, Roel P. F. Schins
Epidemiological studies have related desert dust events to increased respiratory morbidity and mortality. Although the Sahara is the largest source of desert dust, Saharan dust (SD) has been barely examined in toxicological studies. Here, we aimed to assess the NLRP3 inflammasome-caspase-1-pathway-dependent pro-inflammatory potency of SD in comparison to crystalline silica (DQ12 quartz) in an advanced
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The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-10-08 Bang-Yao Chen, Si-Ying Hong, Han-Min Wang, Yi Shi, Peng Wang, Xiao-Juan Wang, Qian-Yang Jiang, Ke-Da Yang, Wei Chen, Xiao-Ling Xu
Recently, mesoporous nanomaterials with widespread applications have attracted great interest in the field of drug delivery due to their unique structure and good physiochemical properties. As a biomimetic nanomaterial, mesoporous polydopamine (MPDA) possesses both a superior nature and good compatibility, endowing it with good clinical transformation prospects compared with other inorganic mesoporous
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Difference in carcinogenicities of two different vapor grown carbon fibers with different physicochemical characteristics induced by intratracheal instillation in rats Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-09-28 Kei Sato, Hiroko Fukui, Yuji Hagiwara, Ryoji Ogawa, Ayako Nishioka, Takamasa Numano, Taiki Sugiyama, Mayumi Kawabe, Yukinori Mera, Tadashi Yoneda
Carbon fibers are high aspect ratio structures with diameters on the submicron scale. Vapor grown carbon fibers are contained within multi-walled carbon tubes, with VGCF™-H commonly applied as a conductive additive in lithium-ion batteries. However, several multi-walled carbon fibers, including MWNT-7, have been reported to induce lung carcinogenicity in rats. This study investigated the carcinogenic
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Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-09-27 Shengjie Hao, Zhijian Chen, Yuzhou Gu, Lu Chen, Feiyin Sheng, Yili Xu, Di Wu, Yu Han, Bing Lu, Shuying Chen, Wei Zhao, Houfa Yin, Xiaofeng Wang, S. Amer Riazuddin, Xiaoming Lou, Qiuli Fu, Ke Yao
Limbal stem/progenitor cells (LSPCs) play a crucial role in maintaining corneal health by regulating epithelial homeostasis. Although PM2.5 is associated with the occurrence of several corneal diseases, its effects on LSPCs are not clearly understood. In this study, we explored the correlation between PM2.5 exposure and human limbal epithelial thickness measured by Fourier-domain Optical Coherence
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Long-term exposure to polystyrene microplastics triggers premature testicular aging Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-08-28 Deyi Wu, Meng Zhang, Ting Ting Bao, Hainan Lan
Plastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans health. The accumulation of MPs in the tissues and blood in animals and humans has been found. There is therefore a need to assess the toxicological effects of MPs on the reproductive system. In this study, we explored the effect of polystyrene microplastics (PS-MPs)
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Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-08-22 Liyan Xiao, Jinyan Pang, Hua Qin, Liyang Dou, Man Yang, Ji Wang, Xianqing Zhou, Yang Li, Junchao Duan, Zhiwei Sun
With the large-scale production and application of amorphous silica nanoparticles (aSiNPs), its adverse health effects are more worthy of our attention. Our previous research has demonstrated for the first time that aSiNPs induced cytokinesis failure, which resulted in abnormally high incidences of multinucleation in vitro, but the underlying mechanisms remain unclear. Therefore, the purpose of this
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Effect of sp3/sp2 carbon ratio and hydrodynamic size on the biodistribution kinetics of nanodiamonds in mice via intravenous injection Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-08-21 Jiyoung Jeong, Soyeon Jeon, Songyeon Kim, Sinuk Lee, Gyuri Kim, Eunsol Bae, Yeonjeong Ha, Seung Whan Lee, Ji-Su Kim, Dong-Jae Kim, Wan-Seob Cho
Nanodiamonds (NDs) have gained a rapidly growing interest in biomedical applications; however, little is known regarding their biokinetics owing to difficulties in measurements and limited synthesis/purification technologies. In this study, we investigated the distribution kinetics of detonation-synthesized NDs in mice via intravenous injection to evaluate the parameters that determine the behavior
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Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-08-14 Ho Young Lee, Dorothy J. You, Alexia Taylor-Just, Logan J. Tisch, Ryan D. Bartone, Hannah M. Atkins, Lauren M. Ralph, Silvio Antoniak, James C. Bonner
Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) has been reported to exert strong pro-inflammatory and pro-fibrotic adjuvant effects in mouse models of allergic lung disease. However, the molecular mechanisms through which MWCNTs exacerbate allergen-induced lung disease remain to be elucidated. We hypothesized that protease-activated receptor 2 (PAR2), a G-protein coupled receptor previously
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Role of different mechanisms in pro-inflammatory responses triggered by traffic-derived particulate matter in human bronchiolar epithelial cells Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-08-03 Magne Refsnes, Tonje Skuland, Rikke Jørgensen, Vegard Sæter-Grytting, Brynhild Snilsberg, Johan Øvrevik, Jørn A. Holme, Marit Låg
Traffic-derived particles are important contributors to the adverse health effects of ambient particulate matter (PM). In Nordic countries, mineral particles from road pavement and diesel exhaust particles (DEP) are important constituents of traffic-derived PM. In the present study we compared the pro-inflammatory responses of mineral particles and DEP to PM from two road tunnels, and examined the
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Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-07-31 Alva Hansson, Gregory Rankin, Oskari Uski, Maria Friberg, Jamshid Pourazar, Robert Lindgren, Natxo García-López, Christoffer Boman, Thomas Sandström, Annelie Behndig, Ala Muala
Exposure to wood smoke has been shown to contribute to adverse respiratory health effects including airway infections, but the underlying mechanisms are unclear. A preceding study failed to confirm any acute inflammation or cell influx in bronchial wash (BW) or bronchoalveolar lavage (BAL) 24 h after wood smoke exposure but showed unexpected reductions in leukocyte numbers. The present study was performed
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Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis Part. Fibre Toxicol. (IF 7.2) Pub Date : 2023-07-19 Shaoqi Yang, Yuheng Sun, Min Long, Xinbei Zhou, Mengqin Yuan, Liliang Yang, Wei Luo, Yusi Cheng, Xinxin Zhang, Wei Jiang, Jie Chao
Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools. Epithelial mesenchymal transition plays an important role in several diseases; however, data on the specific mechanisms in silicosis models are scarce. We elucidated the pathogenesis of pulmonary fibrosis via single-cell