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Glucocorticoid use and parenteral nutrition are risk factors for catheter-related Candida bloodstream infection: a retrospective study Asian Biomed. (IF 0.4) Pub Date : 2024-08-19 Lipeng Huang, Shanshan Li, Ronglin Jiang, Shu Lei, Jiannong Wu, Liquan Huang, Meifei Zhu
Background Catheter-related candidemia (CRC) is a serious catheter-related bloodstream infection (CRBSI) caused by Candida spp., with higher mortality than CRBSIs caused by other organisms. Objective To identify the risk factors for Candida CRBSI. The clinical characteristics of 297 patients with CRBSI in a local hospital from January 2007 to June 2015 were collected, including 33 Candida CRBSI and
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Disseminated gonococcal infection during two decades in the university hospital, Thailand Asian Biomed. (IF 0.4) Pub Date : 2024-08-19 Kanphai Wongjarit, Sittichai Ukritchon
Background Disseminated gonococcal infection (DGI) caused by Neisseria gonorrhoeae commonly presents with the classic triad of polyarthritis, tenosynovitis, and dermatitis. There is no clinical and microbiological data of DGI in Thailand. Objective To study the clinical features, outcomes of treatments, and antimicrobial susceptibility data of DGI patients. Methods All medical records of DGI patients
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The prooxidant–antioxidant balance in diagnosis and developmental prognosis of premature neonates with asphyxia Asian Biomed. (IF 0.4) Pub Date : 2024-08-19 Maryam Zakerihamidi, Boskabadi Hassan, Amirkhani Samin
Background The antioxidant system in a preterm neonate is premature. The imbalance between the prooxidant and antioxidant systems can make these neonates prone to oxidative stress. Birth asphyxia is one of the factors that can disturb this balance. Objective We studied the prooxidant–antioxidant balance (PAB) in the diagnosis and developmental prognosis of preterm neonates with asphyxia. Methods This
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A review of landmark studies on maintenance immunosuppressive regimens in kidney transplantation Asian Biomed. (IF 0.4) Pub Date : 2024-08-19 Suwasin Udomkarnjananun, Maaike R. Schagen, Dennis A. Hesselink
Immunosuppressive medications play a pivotal role in kidney transplantation, and the calcineurin inhibitors (CNIs), including cyclosporine A (CsA) and tacrolimus (TAC), are considered as the backbone of maintenance immunosuppressive regimens. Since the introduction of CNIs in kidney transplantation, the incidence of acute rejection has decreased, and allograft survival has improved significantly. However
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Investigation of the immunological effects of escitalopram oxalate in the breast cancer co-culture model Asian Biomed. (IF 0.4) Pub Date : 2024-08-19 Nalan Biriz, Zerrin Canturk
Background During breast cancer treatment, approximately half of the patients are prescribed psychotropic medication, such as selective serotonin reuptake inhibitors (SSRIs). Escitalopram oxalate is an SSRI used as an antidepressant. Objectives In this study, by creating a breast cancer microenvironment with THP-1, MCF-7 and MDA-MB-231 breast cancer co-culture models were created. Methods MCF-7, MDA-MB-231
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Control of parenteral blood stream infections in patients who need parenteral nutrition. Asian Biomed. (IF 0.4) Pub Date : 2024-06-28
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Magnetic resonance imaging findings of a case with Wolffian tumor and related literature review Asian Biomed. (IF 0.4) Pub Date : 2024-05-02 Can Cui, Dawei Cui, Jiangfeng Pan, Shaobin Zhou, Xiujuan Zheng
Background Wolffian tumors in females are rare gynecological neoplasms, with fewer than 100 cases reported. Existing literature primarily focuses on the pathology, and reports involving imaging are limited. Objective This study presents a case of Wolffian tumor, emphasizing its magnetic resonance imaging (MRI) characteristics to enhance preoperative diagnostic accuracy. Case report A 56-year-old woman
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Elevated level of neuroserpin is an indication for the resistance to gambogic acid-induced apoptosis and oxidative stress in triple-negative breast cancer cells Asian Biomed. (IF 0.4) Pub Date : 2024-05-02 Ertan Kucuksayan, Hakan Kucuksayan, Mehmet Enes Sozen, Aslinur Sircan-Kucuksayan
Background The triple-negative breast cancer (TNBC) subtype, characterized by loss of HER2, estrogen, and progesterone receptors, displays aggressive phenotype and poor prognosis compared to other BC subtypes. Since the TNBC cells are devoid of receptors, endocrine therapy is an ineffective option for TNBC patients, necessitating canonical chemotherapy strategies to treat TNBC. It is crucial to use
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Treatment of cholangiocarcinoma by pGCsiRNA-vascular endothelial growth factor in vivo Asian Biomed. (IF 0.4) Pub Date : 2024-05-02 Shenglin Lu, Jun Li
Background The early diagnosis and treatment of cholangiocarcinoma may benefit from specific tumor markers to be used in clinical practice. Objectives To investigate whether the pGCsiRNA-vascular endothelial growth factor (VEGF) can affect the onset and progression of cholangiocarcinoma and its possible mechanism using the targeted therapy of nude mouse model of cholangiocarcinoma with attenuated Salmonella
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Bedside clinical assessment of patients with common upper limb tremor and algorithmic approach Asian Biomed. (IF 0.4) Pub Date : 2024-05-02 Pattamon Panyakaew, Warongporn Phuenpathom, Roongroj Bhidayasiri, Mark Hallett
The diagnostic approach for patients with tremor is challenging due to the complex and overlapping phenotypes among tremor syndromes. The first step in the evaluation of tremor is to identify the tremulous movement and exclude the tremor mimics. The second step is to classify the tremor syndrome based on the characteristics of tremor from historical clues and focused examination (Axis 1). Comprehensive
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Optimal final adult height achieved by low-dose recombinant human growth hormone therapy Asian Biomed. (IF 0.4) Pub Date : 2024-05-02 Tansit Saengkaew, Suparb Aroonparkmongkol, Suttipong Wacharasindhu
Background Thailand has been administering the recombinant human growth hormone (rhGH) treatment for >20 years. Due to limited resources being available, efforts have been directed toward utilizing rhGH at the lowest feasible dose. However, there is currently a lack of evidence in terms of the efficacy and outcomes. Objective To evaluate the auxological outcomes of growth hormone (GH) treatment and
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Early detection and management of hearing loss to improve the quality of life. Asian Biomed. (IF 0.4) Pub Date : 2024-03-20
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Cutaneous metastasis in hypopharyngeal carcinoma: a case report Asian Biomed. (IF 0.4) Pub Date : 2024-03-20 Rafia Shahzad, Tooba Anjum, Abu Baker Shahid
Background Occurrence of cutaneous metastasis in hypopharyngeal carcinoma is an extremely rare event reported in the literature, with an incidence of only 0.8%–1.3%. Early diagnosis of cutaneous metastasis would have a positive impact on treatment response and disease prognosis with diagnosis mainly dependent on physical examination and radiological imaging (ultrasonography, computed tomography scan
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Management of ectopic pregnancy after in vitro fertilization/intracytoplasmic sperm injection and embryo transfer: a case series and mini-review Asian Biomed. (IF 0.4) Pub Date : 2024-03-20 Yang Zhang, Yan Zhai, Danni Qu
Background Ectopic pregnancy (EP), reflecting a fertilized ovum implanted outside the normal uterine cavity, represents a frequent cause of morbidity and possibly mortality in women of reproductive age. Objective To summarize the diagnosis and treatment of EP after in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET). Methods The medical records of patients who
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Plant-based diets in patients with chronic kidney disease Asian Biomed. (IF 0.4) Pub Date : 2024-03-20 Wannasit Wathanavasin, Piyawan Kittiskulnam, Kirsten L. Johansen
Dietary protein restriction has been considered to be a nutritional-related strategy to reduce risk for end-stage kidney disease among patients with non-dialysis-dependent chronic kidney disease (CKD). However, there is insufficient evidence to recommend a particular type of protein to slow down the CKD progression. Recently, various plant-based diets could demonstrate some additional benefits such
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Establishment and application of a reverse dot blot assay for 13 mutations of hearing-loss genes in primary hospitals in China Asian Biomed. (IF 0.4) Pub Date : 2024-03-20 Qing-Qing Jiang, Juan-Juan Zhu, Shu-Ling Fan, Ya-Ping Hou, Xie-Ying Hu, Jie Shi, Lei Wu, Ying Luo
Background Hearing loss is a common sensorineural dysfunction with a high incidence in China. Although genetic factors are important causes of hearing loss, hearing-related gene detection has not been widely adopted in China. Objective Establishing a rapid and efficient method to simultaneously detect hotspot hearing loss gene mutations. Methods A reverse dot blot assay combined with a flow-through
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Reliability of lateral wall-thickness measurement in trochanteric fractures and parameters associated with lateral wall integrity Asian Biomed. (IF 0.4) Pub Date : 2024-03-20 Chindarat Ratanakornphan, Thanachart Pikulhom, Somjet Jenvorapoj, Chavarin Amarase, Saran Tantavisut
Background The AO Foundation/Orthopaedic Trauma Association (AO/OTA) introduced a new trochanteric fracture classification in January 2018, concerning the lateral wall integrity. It suggested the intramedullary nail fixation in patients with an incompetent lateral wall fracture. Objective To determine the reliability of lateral wall-thickness measurement and the fracture parameters associated with
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The value of platelet/lymphocyte ratio in young patient with acute ischemic stroke. Asian Biomed. (IF 0.4) Pub Date : 2023-12-28
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Lateral flow assay: a promising rapid point-of-care testing tool for infections and non-communicable diseases Asian Biomed. (IF 0.4) Pub Date : 2023-12-28 Kumaravel Vealan, Narcisse Joseph, Sharizah Alimat, Anandi S. Karumbati, Karuppiah Thilakavathy
The point-of-care testing (POCT) approach has established itself as having remarkable importance in diagnosing various infectious and non-communicable diseases (NCDs). The POCT approach has succeeded in meeting the current demand for having diagnostic strategies that can provide fast, sensitive, and highly accurate test results without involving complicated procedures. This has been accomplished by
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Persistence of dengue genome in a remotely infected patient Asian Biomed. (IF 0.4) Pub Date : 2023-12-28 Soraya Thaivanich, Jirayu Visuthranukul, Kesinee Arunyingmongkol, Udomsak Bunworasate, Padet Siriyasatien, Wanla Kulwichit
Background Dengue virus infection is an intriguing illness. It is traditionally thought of as a self-limited and nonpersistent disease. Objectives We report a case with persistent dengue virus genome detectable in hematopoietic cells of a person with remote infection. Methods A patient with multiple myeloma in remission was prepared for peripheral blood stem cell (PBSC) transplantation. Plasma and
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The early predictive value of platelet-to-lymphocyte ratio to hemorrhagic transformation of young acute ischemic stroke Asian Biomed. (IF 0.4) Pub Date : 2023-12-28 Huijun Wen, Ning Wang, Min Lv, Yue Yang, Hongmei Liu
Background The increasing incidence of acute ischemic stroke (AIS) necessitates a comprehensive understanding of the related factors. Hemorrhagic transformation (HT), a severe complication of AIS, is influenced by platelet-induced inflammation and lymphocyte levels. Objective To measure the predictive value of platelet-to-lymphocyte ratio (PLR) in the occurrence of HT in young AIS patients. Methods
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Antibody response to enterotoxigenic Bacteroides fragilis of Filipino colorectal cancer patients Asian Biomed. (IF 0.4) Pub Date : 2023-12-28 Ana Maria D. Cariño, Gregg Austine Balanag, Edrienne Myenna Magat, Allan Fellizar, Teresa Sy Ortin, Oliver Villaflores, Leonardo Guevarra, Pia Marie Albano
Background Several species of the gut microbiota have been implicated in colorectal cancer (CRC) development. The anaerobic bacterium enterotoxigenic Bacteroides fragilis (ETBF), has been identified to produce fragilysin, a toxin known to cleave E-cadherin, thereby leading to carcinogenesis. Objective To determine the antibody response of CRC patients against ETBF to ascertain whether significant difference
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The dose of the normal saline pre-infusion and other risk factors for amphotericin B deoxycholate-associated acute kidney injury Asian Biomed. (IF 0.4) Pub Date : 2023-12-28 Mathurot Virojanawat, Somkanya Tungsanga, Leilani Paitoonpong, Pisut Katavetin
Background Conventional amphotericin B deoxycholate (AmBd) is the preferred amphotericin B formulation in countries with limited resources despite its nephrotoxicity. Normal saline pre-infusion is a recommended measure to reduce the risk of nephrotoxicity in patients receiving AmBd. Objectives To examine the effect of different normal saline solution (NSS) pre-infusion doses, and other potential risk
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Hypertension, preeclampsia, and HELLP syndrome in pregnancy. Asian Biomed. (IF 0.4) Pub Date : 2023-10-26
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Congenital pulmonary hypoplasia combined with congenital cardiac disease and ectopic kidney: a case report Asian Biomed. (IF 0.4) Pub Date : 2023-10-26 Ling Lu, Sujuan Hu, Gaoyan Wang, Rong Jin, Renzheng Guan, Fengjing Cui, Zhenghai Qu, Dongyun Liu
Background Congenital pulmonary hypoplasia (CPH) is a rare pulmonary disease featured by incomplete development of pulmonary tissues. Its diagnosis is still a challenge as patients are usually misdiagnosed as atelectasis. Case presentation A female neonate was admitted to our hospital due to post-birth jaundice for 12 hrs. Physical examination showed accelerated breathing. There was no respiratory
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Alginate–gelatin hydrogel supplemented with platelet concentrates can be used as bioinks for scaffold printing Asian Biomed. (IF 0.4) Pub Date : 2023-10-26 Tuyet Thi Vi Le, Nghia Thi Hieu Phan, Ha Le Bao Tran
Background Owing to the growing global demand for organ replacement and tissue regeneration, three-dimensional (3D) printing is widely recognized as an essential technology in tissue engineering. Biomaterials become a potential source of raw materials for printing ink by containing factors that promote tissue regeneration. Platelet concentrates are autologous biological products that are capable of
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Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study Asian Biomed. (IF 0.4) Pub Date : 2023-10-26 Yusuf Nergiz, Engin Deveci, Erdal Sak, Sıddık Evsen, Selçuk Tunik, Şebnem Nergiz, Fırat Aşır, Uğur Şeker
Background Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is generally considered to be a variant or complication of preeclampsia. It is a life-threatening obstetric complication. Objectives To evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblastand Hoffbauer cells in placental villi of patients with HELLP syndrome. Methods Two groups of patients with
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Enhanced external counterpulsation, focusing on its effect on kidney function, and utilization in patients with kidney diseases: a systematic review Asian Biomed. (IF 0.4) Pub Date : 2023-10-26 Thana Thongsricome, Weerapat Kositanurit, Sarawut Siwamogsatham, Khajohn Tiranathanagul
Background Enhanced external counterpulsation (EECP) is provided by a noninvasive device positively affecting cardiovascular function via mechanisms called diastolic augmentation and systolic unloading. The renal aspects of EECP therapy have not been extensively investigated. Objectives To assess the effect of EECP on renal function and to determine the application in patients with kidney disease.
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Evaluation of the radiosensitizing effect of MEK inhibitor KZ-001 on non-small cell lung cancer cells in vitro Asian Biomed. (IF 0.4) Pub Date : 2023-10-26 Gongchao Huang, Wenqin Zhang, Hongqi Tian
Background Non-small cell lung cancer (NSCLC) has a poor prognosis and usually presents resistance against radiotherapy. MEK inhibitors have been proven to possess a radiosensitization effect. The compound KZ-001 as a particular MEK inhibitor is superior to the listed MEK inhibitor AZD6244. Objective To investigate whether KZ-001 could enhance the radiosensitivity of NSCLC cell lines in vitro. Methods
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Complementary medicine for fatigue: the importance of basic sciences and clinical studies. Asian Biomed. (IF 0.4) Pub Date : 2023-10-18
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Molecular genetic aberrations in the pathogenesis of multiple myeloma Asian Biomed. (IF 0.4) Pub Date : 2023-10-18 Ivyna Pau Ni Bong, Ezalia Esa
Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and highly heterogeneous malignancy, which occurs via a multistep transformation process involving primary and secondary oncogenic events. Recent advances in molecular techniques have further expanded our understanding
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Fibrosarcomatous dermatofibrosarcoma protuberans: a rapidly growing 30 cm mass on the posterior scalp Asian Biomed. (IF 0.4) Pub Date : 2023-10-18 Bhoowit Lerttiendamrong, Pavinee Annoppornchai, Pasu Promniyom
Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing sarcoma of the skin and subcutaneous tissue, accounting for around 5 cases per million per year. Fibrosarcomatous transformation of DFSP occurs in 10%–15% of DFSP cases, with a higher risk of local recurrence, metastasis, and death. We present a case of a male in his 30s with a complaint of rapidly progressive mass in the occipital region
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Effects of coenzyme Q10 in a propofol infusion syndrome model of rabbits Asian Biomed. (IF 0.4) Pub Date : 2023-10-18 Banu Kilicaslan, Seda B Akinci, Fatma Saricaoglu, Savas O Yılbas, Burcu A Ozkaya
Background Coenzyme Q (CoQ) might be the main site of interaction with propofol on the mitochondrial respiratory chain in the propofol infusion syndrome (PRIS) because of the structural similarity between coenzyme Q10 (CoQ10) and propofol. Aim To investigate the effects of CoQ10 on survival and organ injury in a PRIS model in rabbits. Methods Sixteen male New Zealand white rabbits were divided into
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In silico prediction of deleterious non-synonymous SNPs in STAT3 Asian Biomed. (IF 0.4) Pub Date : 2023-10-18 Athira Ajith, Usha Subbiah
Background STAT3, a pleiotropic transcription factor, plays a critical role in the pathogenesis of autoimmunity, cancer, and many aspects of the immune system, as well as having a link with inflammatory bowel disease. Changes caused by non-synonymous single nucleotide polymorphisms (nsSNPs) have the potential to damage the protein's structure and function. Objective We identified disease susceptible
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Screening anti-fatigue components of American ginseng saponin by analyzing spectrum–effect relationship coupled with UPLC-Q-TOF-MS Asian Biomed. (IF 0.4) Pub Date : 2023-10-18 Meiyu Lin, Shaiping Hu, Qi Zeng, Bixia Xiao, Yao He
Background American ginseng has an obvious anti-fatigue effect, but the effective material basis is still unclear. The spectrum–effect relationship is a scientific method that studies the correlations between chemical spectra and pharmacological effect. Objective To reveal the real bioactive compounds in American ginseng saponin (AGS) based on a study of the underlying correlations between these compounds’
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Infection rate among close contacts of patients with coronavirus disease in Japan: a descriptive study and literature review Asian Biomed. (IF 0.4) Pub Date : 2023-10-09 Osamu Yamamura, Hidenori Onishi, Ippei Sakamaki, Ryousuke Fujita, Hirofumi Miyashita, Hiromichi Iwasaki
Background In Japan, on April 20, 2020, the definition of a close contact regarding coronavirus disease (COVID-19) was changed from a long-term contact time to a specified contact time of 15 min and from a contact distance of 2 m to 1 m. Objectives We aimed to determine the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rate among close contacts of patients with COVID-19 and
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The effect of transversus abdominis plane block application on postoperative analgesia quality and patient satisfaction after varicocele surgery: a randomized clinical trial Asian Biomed. (IF 0.4) Pub Date : 2023-10-09 Ömer Faruk Boran, Aykut Urfalioglu, Mahmut Arslan, Fatih Mehmet Yazar, Bora Bilal, Yavuz Orak, Bülent Katı, Ayşe Azak Bozan
Background Postoperative pain management is an important aspect of anesthesia care and multimodal analgesic techniques are generally recommended. Objective To compare the effect of spinal anesthesia + transversus abdominis plane (TAP) block application on postoperative analgesia quality and patient satisfaction with spinal anesthesia + intrathecal morphine (ITM) application. Methods A total of 70 patients
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The relationship between inflammatory biomarkers and macular pigment optical density in hypertensive patients: a cross-sectional study Asian Biomed. (IF 0.4) Pub Date : 2023-10-09 Chunchuree Kongmeesuk Kaneko, Katsunori Kaneko, Vitoon Jularattanaporn, Thamthiwat Nararatwanchai
Background Inflammation may be associated with macular pigment optical density (MPOD) degradation. Objectives The relationship between inflammation and MPOD is evaluated using inflammatory biomarkers, including high sensitivity C-reactive protein (hsCRP), lipid level and ratio, waist circumference (WC), and body mass index (BMI). Method In this cross-sectional design, 62 hypertensive patients were
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Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review Asian Biomed. (IF 0.4) Pub Date : 2023-10-09 Hui-Yin Yow, Sharina Hamzah, Nusaibah Abdul Rahim, Vijayaprakash Suppiah
Background Statins are the most widely used lipid-lowering agents for patients with hyperlipidemia. However, interindividual variations in efficacy and risk of adverse drug reactions to statin treatment have been widely reported. Ethnicity is well known to be one of the contributing factors to this variation, particularly among Asians. Objectives To identify genetic variants associated with statin
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miR-30c-2-3p suppresses the proliferation of human renal cell carcinoma cells by targeting TOP2A Asian Biomed. (IF 0.4) Pub Date : 2023-10-09 Xiaoyong Huang, Yuna Jia, Haiyan Shi, Haiyan Fan, Lingbo Sun, Huahua Zhang, Yanfeng Wang, Jie Chen, Jiaqi Han, Mingming Wang, Juan Du, Jing Zhang
Background The ambiguity of renal cell carcinoma (RCC) symptoms hinders early diagnosis, thereby contributing to high mortality rates. By attaching to the 3′-untranslated region (UTR) of the target gene, microRNAs (miRNAs) exert significant control over the expression of genes. Objectives To investigate the influence of miR-30c-2-3p and DNA topoisomerase II alpha (TOP2A) on RCC growth and the mechanisms
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Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review Asian Biomed. (IF 0.4) Pub Date : 2023-09-16 Jiansheng Zheng, Tang Zhu
Background Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility. Objective To investigate the association between FUT3 gene polymorphisms and IBD. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison
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Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h Asian Biomed. (IF 0.4) Pub Date : 2023-09-16 Guangfeng Zhao, Xiongjun He, Yajie Liu, Liang Zhang, Kaifeng Li
Background Evidence of endovascular treatment (ET) for patients with progressive infarction of the posterior circulation exceeding 24 h is lacking. Objective To evaluate the efficacy and safety of ET for progressive posterior circulation cerebral infarction. Methods This retrospective study evaluated the ET for 18 patients with posterior circulation infarction caused by vertebrobasilar artery occlusion
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Copy number variations of cytochrome P450 genes in Kinh Vietnamese Asian Biomed. (IF 0.4) Pub Date : 2023-09-16 Nhung Phuong Vu, Ton Dang Nguyen, Binh Huy Nguyen, Duong Thuy Nguyen, Hai Van Nong, Ha Hai Nguyen
Background The cytochrome P450 (CYP450) family is well known as a major group of drug metabolizing enzymes. The polymorphism of CYP450 genes is the main factor having an impact on the interindividual difference in drug response, including drug efficacy and drug safety. The single nucleotide polymorphism (SNPs) of Vietnamese Kinh has been widely studied, but information about the copy number variations
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Bacterial isolates and their antimicrobial susceptibility profile of superficial and deep-seated skin and soft tissue infections Asian Biomed. (IF 0.4) Pub Date : 2023-09-16 Rao Muhammad Abid Khan, Sunil Kumar Dodani, Ali Nadeem, Sana Jamil, Mirza Naqi Zafar
Background Skin and soft tissue infections (SSTIs) are caused by microbial invasion of healthy or damaged skin. SSTIs are difficult to manage and contribute to chronicity and emergence of antimicrobial resistance. Objectives To ascertain the prevalence of bacteria causing SSTIs and their antimicrobial susceptibility patterns. Methods A prospective study between November 2020 and May 2021. A total of
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Acidic environment could modulate the interferon-γ expression: Implication on modulation of cancer and immune cells’ interactions Asian Biomed. (IF 0.4) Pub Date : 2023-09-16 Vishal Sharma, Jagdeep Kaur
Background In rapidly growing solid tumors, insufficient vascularization and poor oxygen supply result in an acidic tumor microenvironment, which can alter immune response. Objective To investigate the role of the acidic microenvironment in immune response modulation along with cancer and immune cells’ interactions. Method To mimic the tumor microenvironment conditions, T cells (Jurkat), macrophages
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A case of diphenhydramine intoxication showing prolonged false positive tricyclic antidepressant in the urine assay Asian Biomed. (IF 0.4) Pub Date : 2023-08-12 Dongsun Kim, Hyun Young Shin, Bon D. Ku
Background The urine immunochromatographic assay is a useful screening tool for patients suspected of acute drug intoxication in emergency conditions. Diphenhydramine intoxication shows symptoms similar to those of tricyclic antidepressant (TCA) intoxication. Case presentation We examined a case of diphenhydramine intoxication showing cerebellar ataxia and prolonged false positive results for TCA in
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The contemporary immunoassays for HIV diagnosis: a concise overview. Asian Biomed. (IF 0.4) Pub Date : 2023-08-07 Abdullah,Misbahud Din,Abdul Waris,Muddasir Khan,Sajjad Ali,Riaz Muhammad,Muhammad Salman
Recent advances in human immunodeficiency virus (HIV) diagnostics have improved the management of disease progression significantly, which have also boosted the efficacy of antiviral therapies. The detection of HIV at the earliest is very important. A highly recognized and effective virological biomarker for acute HIV infections is p24 antigen. This brief overview is based on advances of HIV diagnosis
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The burden and control of congenital syphilis: a need for a comprehensive strategy. Asian Biomed. (IF 0.4) Pub Date : 2023-08-07
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Incidence and associated factors of congenital syphilis at a tertiary care center in Thailand Asian Biomed. (IF 0.4) Pub Date : 2023-08-07 Pimchanok Kulsirichawaroj, Dissajee Lumbiganon
Background: The incidence of congenital syphilis is increasing worldwide, in parallel with the increase of syphilis in the general population. Objectives: This study aimed to determine the incidence and risk factors for congenital syphilis at a referral tertiary care center in Bangkok, Thailand. Methods: This is a case–control study using the hospital medical records of neonates born at our hospital
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Accuracy of predictive equations for resting energy expenditure estimation in mechanically ventilated Thai patients Asian Biomed. (IF 0.4) Pub Date : 2023-08-07 Napplika Kongpolprom
Background: Indirect calorimetry (IC) is the most precise approach for estimating calorie demand in critically ill patients. Despite this, owing to unaffordable devices, it is rarely used in practice. Predictive equations are the alternatives. Objectives: To assess the accuracy of 14 predictive resting energy expenditure(REE) equations in ventilated Thai patients. Methods: We compared the accuracy
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Factors affecting the shear wave elastic quantitative measurement of penile tissue in rats Asian Biomed. (IF 0.4) Pub Date : 2023-08-07 Wan-Ting Rao, Jing-Dong Tang, Jin-Fang Xing
Background: As a new ultrasound technology, 2-dimensional shear wave elastography (2D-SWE) can evaluate the elastic characteristics of penile tissue. However, no studies have reported the main factors affecting the shear wave elastic quantitative measurement (SWQ) in penile tissue. Objectives: To analyze the main factors affecting the SWQ reflecting the elastic characteristics of penile tissue by 2D-SWE
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Keratoconus in Thai population - a cross-sectional hospital-based study. Asian Biomed. (IF 0.4) Pub Date : 2023-08-01 Yonrawee Piyacomn,Ngamjit Kasetsuwan,Vilavun Puangsricharern,Usanee Reinprayoon,Vannarut Satitpitakul,Patchima Chantaren
Background Studies in the epidemiology of keratoconus are limited in Southeast Asia. A study on the prevalence and characteristics of keratoconus in the Thai population could give a general idea of its impact. Objectives To study keratoconus prevalence in patients seeking refractive surgery and analyze the characteristics of keratoconus. Methods Medical records from April 2015 to August 2018 were retrospectively
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Use of expanded carrier screening for retrospective diagnosis of two deceased siblings with Van Maldergem syndrome 2: case report Asian Biomed. (IF 0.4) Pub Date : 2023-08-01 Nasim Rahmani, Mohammad Ahmadvand, Golnaz Khakpour
Van Maldergem syndrome (VMLDS) is a recessive disease which affects multiple organs including the face, ear, and limb extremities. It can be caused by pathogenic variants in either the gene DCHS1 or FAT4. Diagnosis of VMLDS is complicated, especially regarding its similarity of symptoms to Hennekam syndrome, another disorder caused by FAT4 variants. Reported patients are two infantile siblings with
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Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study Asian Biomed. (IF 0.4) Pub Date : 2023-08-01 Gunlawadee Maneenil, Waricha Janjindamai, Supaporn Dissaneevate, Anucha Thatrimontrichai
Background Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe hypoxemia and progress to persistent pulmonary hypertension of the newborn (PPHN). Objectives To examine factors associated with the development of PPHN in TTN infants. Methods This retrospective study comprised 23 infants in whom a diagnosis of
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Central resources of variant discovery and annotation and its role in precision medicine Asian Biomed. (IF 0.4) Pub Date : 2023-08-01 Hashim Halim-Fikri, Sharifah-Nany Rahayu-Karmilla Syed-Hassan, Wan-Khairunnisa Wan-Juhari, Mat Ghani Siti Nor Assyuhada, Yetti Hernaningsih, Narazah Mohd Yusoff, Amir Feisal Merican, Bin Alwi Zilfalil
Rapid technological advancement in high-throughput genomics, microarray, and deep sequencing technologies has accelerated the possibility of more complex precision medicine research using large amounts of heterogeneous health-related data from patients, including genomic variants. Genomic variants can be identified and annotated based on the reference human genome either within the sequence as a whole
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Burden of congenital and hereditary anomalies in the war-affected territory at Pakistan–Afghanistan border Asian Biomed. (IF 0.4) Pub Date : 2023-08-01 Muhammad Naeem, Bashir Ahmad, Sajid Malik
Background Pashtun populations of Pakistan are the victim of long-lasting military combats, rendering 1.9 million inhabitants internally displaced. Studies highlighting congenital and hereditary anomalies in these populations are deficient. Objectives To elucidate the spectrum anomalies in the north-western war-affected territories of Pakistan. Methods A cross-sectional study was carried out from 2017