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The inhibitory potential of 4,7-dihydroxycoumarin derivatives on ROS-producing enzymes and direct HOO•/o2• - radical scavenging activity - a comprehensive kinetic DFT study. Free Radic. Res. (IF 3.6) Pub Date : 2024-09-12 Žiko Milanović,Svetlana Jeremić,Marko Antonijević,Dušan Dimić,Đura Nakarada,Edina Avdović,Zoran Marković
This study examined the antiradical activity of three synthesized coumarin derivatives: (E)-3-(1-((2-hydroxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl acetate (A1-OH), (E)-3-(1-((3-hydroxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl acetate (A2-OH), and (E)-3-(1-((4-hydroxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl acetate (A3-OH) against HOO•/O2•- radical species. The investigation included
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EP4 receptor agonist CAY10598 upregulates ROS-dependent Hsp90 cleavage in colorectal cancer cells. Free Radic. Res. (IF 3.6) Pub Date : 2024-09-11 In Gyung Chae,Joohee Jung,Do-Hee Kim,Joon-Seok Choi,Kyung-Soo Chun
Prostaglandin E2 (PGE2) interacts with four specific G protein-coupled receptors, namely EP1, EP2, EP3, and EP4, playing a pivotal role in determining the fate of cells. Our previous findings highlighted that stimulating the EP4 receptor with its agonist, CAY10598, triggers apoptosis in colon cancer HCT116 cells via the production of reactive oxygen species (ROS). This process also reduces the phosphorylation
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Polyphenolic metacyclophane as a radical scavenger for therapeutic activation: a computational study Free Radic. Res. (IF 3.6) Pub Date : 2024-08-22 Raktim Nath, Alaiha Zaheen, Sanchaita Rajkhowa, Rahul Kar
Modeling antioxidants for improved human health is a prime area of research. Inclusion complexes exhibit antioxidant activity. Supramolecular scaffolds like calixtyrosol are anticipated to have con...
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Reduction of oxidative damage in prostate tissue caused by radiation and/or chloroquine by apocynin Free Radic. Res. (IF 3.6) Pub Date : 2024-08-16 Onur Ertik, Ayca Sezen Us, Ilknur Bugan Gul, Huseyin Us, Melis Coremen, Omur Karabulut Bulan, Refiye Yanardag
Prostate damage can occur in men due to age and genetic factors, especially when exposed to external factors. Radiation (RAD) is a prominent factor leading to oxidative stress and potential prostat...
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Hydroxyl radical scavenging and chemical repair capabilities of positively charged peptides (PCPs): a pulse radiolysis study Free Radic. Res. (IF 3.6) Pub Date : 2024-08-08 Chaozhong Tian, Shinichi Yamashita, Atsushi Kimura, Yui Obata, Hao Yu, Mitsumasa Taguchi
Pulse radiolysis was employed to investigate fundamental radiation chemical reactions, which are essential in the radiation protection of DNA. Two positively charged peptides (PCPs), histidine-tyro...
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Regulation of cancer cell ferroptosis by PTRF/Cavin-1 Free Radic. Res. (IF 3.6) Pub Date : 2024-08-07 Hui Xiang, Miao Wang, Yi-Fang Chen, Hao-Ming Wu, Ming-Ge Li, Lei Guo, Ying-Yi Zhang, He-Zhe Lu
Ovarian cancer, marked by high rate of recurrence, novel therapeutic strategies are needed to improve patient outcome. One of the potential strategies is inducing ferroptosis in ovarian cancer cell...
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Antioxidant properties of α-amino acids: a density functional theory viewpoint Free Radic. Res. (IF 3.6) Pub Date : 2024-08-05 Andrey A. Buglak
The antioxidant properties of 21 proteinogenic amino acids (AAs) and 3,4-dioxophenylanine (DOPA) have been studied in implicit water using density functional theory (DFT). All the calculations have...
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Heme-catalyzed degradation of linoleate 9-hydroperoxide (9-HPODE) forms two allylic epoxy-ketones via a proposed pseudo-symmetrical diepoxy radical intermediate Free Radic. Res. (IF 3.6) Pub Date : 2024-08-04 Saori Noguchi, William E. Boeglin, Ned A. Porter, Alan R. Brash
Heme-initiated decomposition of unsaturated fatty acid hydroperoxides creates alkoxyl radicals that propagate a complex series of reactions to hydroxy, keto, epoxy and aldehydic products. Herein, a...
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The effect of hypochlorous acid inhalation on the activity of antioxidant system enzymes in rats of different ages Free Radic. Res. (IF 3.6) Pub Date : 2024-08-01 Bohdan Murashevych, Hanna Maslak, Dmitry Girenko, Olha Abraimova, Olha Netronina, Volodymyr Shvets
Hypochlorous acid HOCl is an effective disinfectant with a broad spectrum and high rate of microbicidal action. Its use for air treatment can be an effective tool for the prevention and therapy of ...
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Ferroptosis: a new target for hepatic ischemia-reperfusion injury? Free Radic. Res. (IF 3.6) Pub Date : 2024-07-31 Shanshan Guo, Zexin Li, Yi Liu, Ying Cheng, Degong Jia
Ischemia-reperfusion injury (IRI) can seriously affect graft survival and prognosis and is an unavoidable event during liver transplantation. Ferroptosis is a novel iron-dependent form of cell deat...
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Correction Free Radic. Res. (IF 3.6) Pub Date : 2024-07-25
Published in Free Radical Research (Vol. 58, No. 6-7, 2024)
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Indole-3-carbinol loaded-nanocapsules modulated inflammatory and oxidative damages and increase skin wound healing in rats Free Radic. Res. (IF 3.6) Pub Date : 2024-07-04 Daniel Vargas, Hecson Segat, Mailine Gehrcke, Vinicius Costa Prado, Karine Roversi, Sabrina Grendene Muller, Patrícia Severo do Nascimento, Cristina Wayne Nogueira, Marilise Escobar Burger, Fabiana Elias, Leonardo Gruchouskei, Letícia Cruz, Daniel Curvello de Mendonça Muller
This study evaluated the effects of topically applied hydrogels (HG) containing nanoencapsulated indol-3-carbinol (I3C) and its free form in a rat model of skin wounds. Formulations were topically ...
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The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice Free Radic. Res. (IF 3.6) Pub Date : 2024-07-01 Lei Xu, Jie Jia, Jingjing Yu, Shudan Miao, Ying Zhang
It is well known that the adaptations of muscular antioxidant system to aerobic exercise depend on the frequency, intensity, duration, type of the exercise. Nonetheless, the timing of aerobic exerc...
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Unveiling an oxidative stress-linked diagnostic signature and molecular subtypes in preeclampsia: novel insights into pathogenesis Free Radic. Res. (IF 3.6) Pub Date : 2024-06-04 Rurong Mao, Li Li, Penghao Li
Preeclampsia (PE) is a complex pregnancy disorder characterized by hypertension and organ dysfunction, affecting both maternal and fetal health. Oxidative stress has been implicated in the pathogen...
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Enhanced anticancer activity of (–)-epigallocatechin-3-gallate (EGCG) encapsulated NPs towards colon cancer cell lines. Free Radic. Res. (IF 3.6) Pub Date : 2024-05-29 Tanushree Das, Sanchaita Mondal, Sujata Das, Sanjib Das, Krishna DasSaha
(–)-Epigallocatechin-3-gallate (EGCG), a bioactive polyphenol of green tea has chemo- preventive effects against various cancer cells. Nanoparticles (NPs) carrying different ligands are able to spe...
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Mechanism of non-thermal atmospheric plasma in anti-tumor: influencing intracellular RONS and regulating signaling pathways Free Radic. Res. (IF 3.6) Pub Date : 2024-05-24 Wenjie Wang, Peijia Zheng, Liang Yan, Xiaoman Chen, Zhicheng Wang, Qi Liu
Non-thermal atmospheric plasma (NTAP) has been proven to be an effective anti-tumor tool, with various biological effects such as inhibiting tumor proliferation, metastasis, and promoting tumor cel...
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Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic stress in HepG2 cells Free Radic. Res. (IF 3.6) Pub Date : 2024-05-11 Hanako Aoki, Yasuhiro Shinkai, Masahiro Akiyama, Satoshi Yamazaki, Motohiro Nishida, Yoshito Kumagai
While cysteine (CysSH) is known to be exported into the extracellular space, its biological significance is not well understood. The present study examined the movement of extracellular CysSH using...
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Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling Free Radic. Res. (IF 3.6) Pub Date : 2024-04-22 Yen Nhi Doan Nguyen, Ji Hoon Jeong, Naveen Sharma, Ngoc Kim Cuong Tran, Hoang-Yen Phi Tran, Duy-Khanh Dang, Jung Hoon Park, Jae Kyung Byun, Sung Kwon Ko, Seung-Yeol Nah, Hyoung-Chun Kim, Eun-Joo Shin
It was demonstrated that ginsenosides exert anti-convulsive potentials and interleukin-6 (IL-6) is protective from excitotoxicity induced by kainate (KA), a model of temporal lobe epilepsy. Ginseno...
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Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria Free Radic. Res. (IF 3.6) Pub Date : 2024-04-22 Danyang Mi, Izumi Yanatori, Hao Zheng, Yingyi Kong, Tasuku Hirayama, Shinya Toyokuni
Iron is essential for all the lives and mitochondria integrate iron into heme and Fe-S clusters for diverse use as cofactors. Here, we screened mitochondrial proteins in KU812 human chronic myeloge...
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Calorie restriction anti-hypertrophic effects are associated with improved mitochondrial content, blockage of Ca2+-induced mitochondrial damage, and lower reverse electron transport-mediated oxidative stress Free Radic. Res. (IF 3.6) Pub Date : 2024-04-17 Aline Maria Brito Lucas, Plinio Bezerra Palacio, Pedro Lourenzo Oliveira Cunha, Heberty Tarso Facundo
Calorie restriction is a nutritional intervention that reproducibly protects against the maladaptive consequences of cardiovascular diseases. Pathological cardiac hypertrophy leads to cellular grow...
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The effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto’s thyroiditis Free Radic. Res. (IF 3.6) Pub Date : 2024-04-16 Sümeyye Tunç, Şükriye Leyla Altuntaş, Murat Atmaca, Çağrı Çakıcı, Türkan Yiğitbaşı, Yeong‑Cheng Liou, Wei-An Chang
This study aimed to examine the effects of low-level laser therapy (LLLT) combined with levothyroxine replacement therapy on thyroid function, oxidative stress (OS), and quality of life in patients...
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A novel diselenide attenuates the carrageenan-induced inflammation by reducing neutrophil infiltration and the resulting tissue damage in mice Free Radic. Res. (IF 3.6) Pub Date : 2024-04-08 Tássia Liz Araújo dos Santos Lessa, Thiago Macêdo Lopes Correia, Talita Costa dos Santos, Railmara Pereira da Silva, Beatriz Pereira da Silva, Maria Cláudia Magalhães Cavallini, Leonardo Silva Rocha, Albert Souza Peixoto, Beatriz S. Cugnasca, Gustavo Cervi, Thiago C. Correra, Augusto Cesar Gonçalves, William Tadeu Lara Festuccia, Thiago Mattar Cunha, Regiane Yatsuda, Amélia Cristina Mendes de Magalhães
Selenium-containing compounds have emerged as promising treatment for redox-based and inflammatory diseases. This study aimed to investigate the in vitro and in vivo anti-inflammatory activity of a...
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Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells Free Radic. Res. (IF 3.6) Pub Date : 2024-04-05 Upasana Ganguly, Sukhpal Singh, Aritri Bir, Arindam Ghosh, Sankha Shubhra Chakrabarti, Reena V. Saini, Luciano Saso, Marco Bisaglia, Sasanka Chakrabarti
Ferroptosis has been characterized as a form of iron-dependent regulated cell death accompanied by an accumulation of reactive oxygen species and lipid oxidation products along with typical morphol...
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Biocompatibility assessment of bovine serum albumin conjugated manganese dioxide nanoparticle and their therapeutic role against microwave radiation induced haematological toxicity in male Wistar rats Free Radic. Res. (IF 3.6) Pub Date : 2024-04-02 Sonali Pardhiya, Usha Singh Gaharwar, Ajith Manayil Parambil, Jay Prakash Nirala, Paulraj Rajamani
Microwave (MW) radiations are widely used in communications, radar and medical treatment and thus human exposure to MW radiations have increased tremendously, raising health concerns as MW has been...
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Humanin inhibits lymphatic endothelial cells dysfunction to alleviate myocardial infarction-reperfusion injury via BNIP3-mediated mitophagy Free Radic. Res. (IF 3.6) Pub Date : 2024-03-27 Lu Chen, Xiaohua Yang, Kai Wang, Lina Guo, Cao Zou
Acute myocardial infarction (AMI) ranks among the top contributors to sudden death and disability worldwide. It should be noted that current therapies always cause increased reperfusion damage. Evi...
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Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway Free Radic. Res. (IF 3.6) Pub Date : 2024-03-22 Yixin Zhang, Youcheng Zeng, Ming Huang, Guodong Cao, Liang Lin, Xiaoyue Wang, Qinghong Cheng
Sepsis is a systemic inflammatory response syndrome caused by infection, which causes renal dysfunction known as sepsis-associated acute kidney injury (S-AKI). Ferroptosis is a form of lipid peroxi...
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Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity Free Radic. Res. (IF 3.6) Pub Date : 2024-03-21 Shu Tanaka, Sae Hayashi, Tomohiro Otsuka, Tetsuro Kamiya, Kenji Ishikawa, Hirokazu Hara
Non-thermal atmospheric pressure plasma (NTP), an ionized gas containing electrons, ions, radicals, and photons, has various biological effects, including wound healing and anticancer effects. Plas...
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Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model Free Radic. Res. (IF 3.6) Pub Date : 2024-03-08 Lixuan Chen, Qinglin Mo, Yingnan Wu, Wancheng Chen, Kaixian Deng, Yang Xiao
Oxidative stress injury is an important pathological factor of premature ovarian failure (POF). Salidroside, extracted from the Chinese herb-Rhodiola rosea, has advantages in antioxidant characteri...
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Superoxide-producing associates from gastrointestinal bacteria: stimulation of its growth by exogenous superoxide-producing complex from raspberries Free Radic. Res. (IF 3.6) Pub Date : 2024-03-01 Ruzan M. Simonyan, Sona M. Feschyan, Roza A. Madoyan, Gegham M. Simonyan, Hasmik H. Sargsyan, Madlena A. Babayan, Hasmik H. Yekmalyan, Magdalina M. Melkonyan, Maxim A. Simonyan, Ashkhen L. Manukyan
Aerobic organisms including the gut microbiota have an essential antioxidant status, as a result of which these bacteria protect organisms from various pathologies and diseases. The goal of the giv...
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Brca2(p.T1942fs/+) dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells Free Radic. Res. (IF 3.6) Pub Date : 2024-02-29 Hideaki Tanaka, Yashiro Motooka, Yuki Maeda, Reina Sonehara, Tomoko Nakamura, Hiroaki Kajiyama, Tomoji Mashimo, Shinya Toyokuni
Pathogenic variants of BRCA1/2 constitute hereditary breast and ovarian cancer (HBOC) syndrome, and BRCA1/2 mutant is a risk for various cancers. Whereas the clinical guideline for HBOC patients ha...
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Enhancing effect of the coexisting alpha-tocopherol on quercetin absorption and metabolism Free Radic. Res. (IF 3.6) Pub Date : 2024-02-28 Rikito Mitsuzane, Reiko Okubo, Miyu Nishikawa, Shinichi Ikushiro, Shintaro Munemasa, Yoshiyuki Murata, Yoshimasa Nakamura, Toshiyuki Nakamura
The aim of this study is to investigate the modulating effect of coexisting food components on the absorption and metabolism of quercetin and blood plasma antioxidant potentials. The combination of...
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The role of oxidative stress and inflammation biomarkers in pre- and postoperative monitoring of prostate cancer patients Free Radic. Res. (IF 3.6) Pub Date : 2024-02-23 Hakan Beyaztas, Cevper Ersoz, Beyza Nur Ozkan, Ibrahim Olgun, Hayati Sencer Polat, Ali Imran Dastan, Emre Cetinkaya, Eray Metin Guler
Prostate Cancer (PC) is a global health concern affecting men worldwide. Oxidative stress is believed to contribute to the initiation of early-stage PC lesions. Additionally, inflammation has long ...
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Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer Free Radic. Res. (IF 3.6) Pub Date : 2024-02-22 Kaiyuan Wu, Le Liu, Zhenhua Wu, Qi Huang, Lei Zhou, Rujiao Xie, Miao Wang
Ferroptosis is recognized as a new type of regulated cell death initiated by iron-dependent accumulation of lipid peroxidation. Recent studies have shown that the administration of ascorbic acid (A...
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Renoprotective effect of esculetin against ischemic acute kidney injury-diabetic comorbidity Free Radic. Res. (IF 3.6) Pub Date : 2024-02-12 Neha Dagar, Tahib Habshi, Vishwadeep Shelke, Hemant R. Jadhav, Anil Bhanudas Gaikwad
Mitophagy maintains cellular homeostasis by eliminating damaged mitochondria. Accumulated damaged mitochondria can lead to oxidative stress and cell death. Induction of the PINK1/Parkin-mediated mi...
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Bis(1-methylimidazol-2-yl) diselenide and its evaluation as a chemical radio-protector: role of kinetic rate constants for ROS scavenging and glutathione peroxidase like activity Free Radic. Res. (IF 3.6) Pub Date : 2024-02-07 K. Makhijani, L. B. Kumbhare, M. Nayak, A. Kunwar, B. G. Singh
Bis(1-methylimidazol-2-yl) diselenide (MeImSe), a derivative of selenoneine, has been examined for bimolecular rate constants for scavenging of various radiolytically and non-radiolytically generat...
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Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice Free Radic. Res. (IF 3.6) Pub Date : 2024-02-07 Xianchao Li, Yang Wu, Yunzhao Yang, Yaohua Wu, Xi Yu, Wenjuan Hu
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcriptional regulator that plays a protective role against various cardiovascular diseases. Omaveloxolone is a newly discovere...
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Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH Free Radic. Res. (IF 3.6) Pub Date : 2024-02-07 Lucia Kovacikova, Marta S. Prnova, Pavol Bodo, Milan Stefek
In the model system of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) liposomes exposed to peroxyl radicals generated by the azoinitiator AAPH, cemtirestat (CMTI-SH) inhibited lipid peroxidation m...
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A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages Free Radic. Res. (IF 3.6) Pub Date : 2024-02-07 Gaochao Dong, Xuewen Yin, Yingkuan Liang, Jingwen Chen, Jie Wang, Feng Jiang, Chaochen Wang, Wenwen Guo, Yaping Wang
An inverted AluYb8 insertion in the MUTYH intron 15 (AluYb8MUTYH variant) has been reported to be associated with reduced MUTYH1 expression and mitochondrial dysfunction with age. However, the unde...
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Recent advances in the antioxidant activity of metal-curcumin complexes: a combined computational and experimental review Free Radic. Res. (IF 3.6) Pub Date : 2024-02-07 Ankit Mittal, Mudita Nagpal, Vinod Kumar Vashistha, Richa Arora, Upasana Issar
Curcumin, an extensively studied phytochemical compound, has gained attention for its potential therapeutic applications across a spectrum of diseases. Its notable attributes include its relatively...
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Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Vandana Yadav, Vinita Pandey, Atul Srivastava, Sangita Singh, Subhashini
Chronic obstructive pulmonary disease (COPD) is defined by inflammation and emphysema. Sirtuins (SIRT) are NAD+-dependent histone deacetylases that regulate oxidative stress and inflammation. The p...
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Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Ghadeer Abbas, Fatemah Alibrahim, Rawan Kankouni, Sara Al-Belushi, Dalal A. Al-Mutairi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
Coordination of metal ions by the tetrapyrrolic macrocyclic ring of porphyrin-based photosensitizers (PSs) affects their photophysical properties and consequently, their photodynamic activity. Diam...
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Elevated oxidative stress in patients with congenital heart disease and the effect of cyanosis: a meta-analysis Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Inne Vanreusel, Jan Taeymans, Emeline Van Craenenbroeck, Vincent F. M. Segers, An Van Berendoncks, Jacob J. Briedé, Wendy Hens
Oxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders. To improve therapy and preventive strategies, clinicians need a better underst...
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N-acetylcysteine modulates redox imbalance and inflammation in macrophages and mice exposed to formaldehyde Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Elena Cecilia Marcano-Gómez, Ana Beatriz Farias de Souza, Pedro Alves Machado-Junior, Andrea Jazel Rodríguez-Herrera, Thalles de Freitas Castro, Sirlaine Pio Gomes da Silva, Ramony Gonzaga Vieira, André Talvani, Katiane de Oliveira Pinto Coelho Nogueira, Laser Antônio Machado de Oliveira, Frank Silva Bezerra
This study aimed to evaluate the protective role of N-acetylcysteine (NAC) in cells and mice exposed to formaldehyde. For the in vitro study, J774A.1 macrophages cells were incubated for 8, 16 and ...
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The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Andris Elksnis, Nils Welsh, Per Wikström, Joey Lau, Per-Ola Carlsson
NADPH oxidase 4 (NOX4) inhibition has been reported to mitigate diabetes-induced beta-cell dysfunction and improve survival in vitro, as well as counteract high-fat diet-induced glucose intolerance...
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Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Yunguang Wang, Xinxin He, Mengjiao Xue, Wenbo Sun, Qiang He, Juan Jin
Mitophagy is a critical intracellular event during the progression of diabetic nephropathy (DN). Our previous study demonstrated that germacrone has anti-ferroptotic properties and is a potential t...
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Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Mana Kitao, Ai Yamaguchi, Takuma Tomioka, Kenji Kai, Yuki Kamei, Kenji Sugimoto, Mitsugu Akagawa
Age-related macular degeneration (AMD) is one of an increasing number of diseases that causes irreversible impairment and loss of vision in the elderly. AMD occurs by oxidative stress-mediated apop...
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The relationship between serum superoxide dismutase and thyroid function in obese patients after Laparoscopic sleeve gastrectomy Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Hui You, Xin Wen, Xingchun Wang, Cuiling Zhu, Manna Zhang, Le Bu, Haibing Chen, Chunjun Sheng, Shen Qu
To investigate the cross-sectional and longitudinal correlation between serum superoxide dismutase (SOD) levels and thyroid function with obesity before and after laparoscopic sleeve gastrectomy (L...
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Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease Free Radic. Res. (IF 3.6) Pub Date : 2023-12-26 Jada D. Williams, Ravi Kumar, Jeremiah M. Afolabi, Frank Park, Adebowale Adebiyi
Individuals with sickle cell disease (SCD) are at greater risk of rhabdomyolysis, a potentially life-threatening condition resulting from the breakdown of skeletal muscle fibers. Acute kidney injur...
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Epoxides: an underestimated lipid oxidation product Free Radic. Res. (IF 3.6) Pub Date : 2023-12-20 Karen M. Schaich
Immense gains in understanding of mechanisms and effects of lipid oxidation have been achieved in the nearly 90 years over which lipid oxidation has been an active research focus. Even so, the subs...
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Arachidonic Acid: Reconciling the Dichotomy of its Oxidative Cascade through Specific Deuteration Free Radic. Res. (IF 3.6) Pub Date : 2023-10-28 J. Thomas Brenna, Marina G. Sergeeva, Nikolay B. Pestov, Tatyana V. Korneenko, Mikhail S. Shchepinov
A new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic proce...
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Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation Free Radic. Res. (IF 3.6) Pub Date : 2023-08-29 Muhammad Shoaib, Nancy Kim, Rishabh C. Choudhary, Blanca Espin, Mitsuaki Nishikimi, Ann Iverson, Tsukasa Yagi, Seyedeh Shadafarin Marashi Shoshtari, Koichiro Shinozaki, Lance B. Becker, Junhwan Kim
Abstract Oxidative stress is believed to be a major cause of injury after cardiac arrest (CA). While the effects of ROS generated within tissues have been extensively investigated, the potential of plasma-generated ROS in contributing to CA pathology has not been examined. We utilized Amplex Red (AR) to measure the real time-generation of ROS in isolated plasma from human CA patients. We first used
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Molecular targets for anti-oxidative protection of açaí berry against diabetes myocardial ischemia/reperfusion injury Free Radic. Res. (IF 3.6) Pub Date : 2023-08-26 Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Tiziana Genovese, Rosalia Crupi, Livia Interdonato, Maurizio Evangelista, Rosanna Di Paola, Salvatore Cuzzocrea, Ramona D’Amico
Myocardial ischemia/reperfusion injury (MIRI) is the principal cause of death and occurs after prolonged blockage of the coronary arteries. Diabetes represents one of the main factors aggravating m...
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Fullerene C60 reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/caspase-3/beclin-1/IL-1α/HO-1/p53 signaling pathways in rats Free Radic. Res. (IF 3.6) Pub Date : 2023-08-26 Seda Beyaz, Abdullah Aslan, Ozlem Gok, Ibrahim Hanifi Ozercan, Can Ali Agca
Abstract The objective of this study was to evaluate the effect of fullerene C60 nanoparticles against 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tissue damage in rats. 60 Wistar albino (8 weeks old) female rats were assigned into four groups: Control Group (C), Fullerene C60, DMBA, and Fullerene C60+DMBA. The rats in the DMBA and Fullerene C60+DMBA groups were administered DMBA (45 mg/kg bw
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Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage Free Radic. Res. (IF 3.6) Pub Date : 2023-08-09 Junichi Fujii, Ken-ichi Yamada
The presence of hydrogen peroxide along with ferrous iron produces hydroxyl radicals that preferably oxidize polyunsaturated fatty acids (PUFA) to alkyl radicals (L•). The reaction of L• with an ox...
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DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species Free Radic. Res. (IF 3.6) Pub Date : 2023-08-03 Fanwei Meng, Junfeng Ke, Feng Guo, Jiaqing Yan, Liping Wang
Abstract Inflammation is a defensive immune response to external stimuli. However, uncontrolled inflammation may cause potential damage to the host. Therefore, timely control of uncontrolled inflammation is particularly important. Previous studies have found that small molecules with antioxidant activity, such as peroxidase mimic enzymes, can inhibit the development of inflammation. DhHP-6 is a new
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Molecular dissection of anti-colon cancer activity of NARI-29: Special focus on H2O2 modulated NF-κB and death receptor signaling Free Radic. Res. (IF 3.6) Pub Date : 2023-07-31 Syamprasad NP, Bishal Rajdev, Siddhi Jain, Jagadeesh Kumar Gangasani, Jayathirtha Rao Vaidya, VGM Naidu
Abstract Accumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are the main factor responsible for cancer progression and drug resistance. Epalrestat is the only AR inhibitor being used in Asian countries. It did not make it to the markets of the USA and Europe due to marginal efficacy as an antioxidant and anti-inflammatory agent owing to difficulty
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Association of Circulatory PCSK-9 with Biomarkers of Redox Imbalance and Inflammatory Cascades in the Prognosis of Diabetes and Associated Complications: A Pilot Study in the Indian Population Free Radic. Res. (IF 3.6) Pub Date : 2023-07-17 Mohd Waiz, Sahir Sultan Alvi, M. Salman Khan
Abstracts Besides the profound role of proprotein convertase subtilisin/kexin type-9 (PCSK-9) in LDL-C regulation, its association with other metabolic complications cannot be disregarded. The co-existence of redox imbalance and inflammatory cascades has greatly reflected the etiology of hyperglycemia. Therefore, we studied the association of PCSK-9 with inflammation and oxidative stress biomarkers
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Dissecting the potential role of ferroptosis in liver diseases: an updated review Free Radic. Res. (IF 3.6) Pub Date : 2023-07-04 Gaoyue Guo, Wanting Yang, Chao Sun, Xiaoyu Wang
Abstract Ferroptosis is a novel form of cell death, manifested by iron-dependent, non-apoptotic manner resulting from the intracellular accumulation of large clusters of reactive oxygen species (ROS) and lipid peroxides due to abnormal iron metabolism. Since the liver is the main organ of human body for storing iron, it is essential to perform in-depth investigation on the role and mechanistic basis
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Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork Free Radic. Res. (IF 3.6) Pub Date : 2023-07-04 Fengjiao Zhang, Renjie Zhang, Songgui He, Jingyi Guan, Zhaoxing Feng, Zhenqiang Wu
Abstract Soaking aged fat pork is a special aging process in the production of Chi-aroma Baijiu considered to involve the formation of free radicals. This study aimed to investigate the free radicals’ formation pathway in Chi-aroma Baijiu during aged fat pork soaking by using electron paramagnetic resonance (EPR) and spin trapping with 5,5-dimethyl-1-pyrrolin-n-oxide (DMPO). The alkyl radical adducts
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Generation and measurement of low-temperature plasma for cancer therapy: a historical review Free Radic. Res. (IF 3.6) Pub Date : 2023-07-04 Kenji Ishikawa, Keigo Takeda, Shinji Yoshimura, Takashi Kondo, Hiromasa Tanaka, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori
Abstract This review provides a description of the historical background of the development of biological applications of low-temperature plasmas. The generation of plasma, methods and devices, plasma sources, and measurements of plasma properties, such as electron dynamics and chemical species generation in both gaseous and aqueous phases, were assessed. Currently, direct irradiation methods for plasma