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A Two-step Bayesian Mendelian Randomization Study on Cholecystitis and Dermatitis medRxiv. Dermatol. Pub Date : 2024-09-18 Chenyu Zhao, Changqian Cen, Ruihan Zhang, Wenjin He, Yiyang Jiao, Zhuoya Chen, Zhaoqi Wu, Ting Luan
Abstract: Background: Cholecystitis is an inflammatory disease involving the gallbladder, often associated with digestive disorders and systemic immune response. This systemic immune response could potentially influence the immune status of the skin, particularly in conditions like dermatitis. Despite extensive research on dermatitis, the causal relationship between cholecystitis and dermatitis subtypes
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Risk of Major Adverse Cardiovascular Events following Nicotinamide Exposure: Cohort Study medRxiv. Dermatol. Pub Date : 2024-09-16 Lee Wheless, Ranya Guennoun, Basia M Michalski, Katlyn M Gonzalez, Rachel Weiss, Siwei Zhang, Lydia Yao, Christopher Madden, Hua-Chang Chen, Jefferson Triozzi, Ran Tao, Otis D Wilson, Quinn S Wells, Adriana M Hung, Kristin Bibee, Rebecca I Hartman, Yaomin Xu, Million Veteran Program
IMPORTANCE. Nicotinamide metabolites have recently been implicated in increased risk of major cardiovascular events (MACE). Supportive data about clinical risk of MACE for nicotinamide users is lacking. OBJECTIVE. To determine whether nicotinamide use results in an increase of MACE. DESIGN, SETTING, PARTICIPANTS. Retrospective cohort study of two patient cohorts, Vanderbilt University Medical Center
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Methodological issues in visible LED therapy dermatological research and reporting medRxiv. Dermatol. Pub Date : 2024-09-13 David Robert Grimes
The advent of mass-market Light Emitting Diodes (LEDs) has seen considerable interest in potential dermatological applications of LED light photobiomodulation (PBM) for a range of conditions, with a thriving market for direct-to-consumer LED treatments, including red light, blue light, and yellow light wavelengths. Evidence of efficacy for many conditions is however decidedly mixed, with starkly different
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Leveraging Machine Learning & Mobile Application Technology for Vitiligo Management: A Proof-of-Concept medRxiv. Dermatol. Pub Date : 2024-09-06 Mahla Abdolahnejad, Hyerin Jeong, Victoria Lin, Tiffany Ng, Emad Altaki, Anthea Mo, Burak Yildiz, Hannah O. Chan, Collin Hong, Rakesh Joshi
Vitiligo, a dermatological condition characterized by depigmented patches on the skin, affects up to 2% of the global population. Its management is complex, often hindered by delayed diagnosis due to limited access to dermatologists and/ digital tools. Recent advancements in machine learning (ML) offer a potential solution by providing digital tools for early detection and management. This proof-of-concept
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Nationwide melanoma registry databases in real-world settings: a scoping review protocol medRxiv. Dermatol. Pub Date : 2024-08-29 Songchun Yang, Dilan Deng, Wenrui Lin, Xiaozhen Chen, Shuang Zhao, Lixia Lu, Yi Xiao, Minxue Shen, Mingliang Chen, Xiang Chen, Juan Su
Introduction A patient registry database is an important tool to address a wide range of research questions. Several countries have established nationwide melanoma registry databases. However, there is no report on summarising and comparing these databases. This scoping review aims to answer a broad question on how contemporary nationwide melanoma registry databases were conducted across different
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Comprehensive Review of Adverse Effects in Minimally Invasive Cosmetic Procedures: Insights from a Decade of Clinical Data medRxiv. Dermatol. Pub Date : 2024-08-23 Cristina Guadalupe Beltran Munoz, Elissa Bracamontes Perez, Fernanda Corrales Bay, Aimee Adriana Barajas Nieto, Kate Georgette Rojo Navarro
Introduction: Minimally invasive cosmetic procedures are medical interventions that do not involve the use of surgical incisions. They are usually based on the administration of biocompatible compounds into subcutaneous or dermal tissue. Although considered low-risk, they can have significant adverse effects such as tissue damage or occlusion of superficial blood vessels. Describing their complications
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Explainable, federated deep learning model predicts disease progression risk of cutaneous squamous cell carcinoma medRxiv. Dermatol. Pub Date : 2024-08-22 Juan Ignacio Pisula, Doris Helbig, Lucas Sancere, Oana-Diana Persa, Corinna Burger, Anne Frolich, Carina Lorenz, Sandra Bingmann, Dennis Niebel, Konstantin Drexler, Jennifer Landsberg, Roman Thomas, Katarzyna Bozek, Johannes Bragelmann
Predicting cancer patient disease progression is a key step towards personalized medicine and secondary prevention. The ability to predict which patients are at an elevated risk of developing local recurrences or metastases would allow for tailored surveillance of these high-risk patients as well as enhanced and timely interventions. We developed a deep learning transformer-based approach for prediction
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Expression of C5aR1 in Cutaneous Squamous Cell Carcinoma is Associated with Invasion, Metastasis and Poor Prognosis medRxiv. Dermatol. Pub Date : 2024-08-19 Lauri Heiskanen, Liisa Nissinen, Elina Siljamaki, Jaakko Knuutila, Teijo Pellinen, Markku Kallajoki, Jyrki Heino, Pilvi Riihila, Veli-Matti Kahari
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic disease is associated with poor prognosis. We have examined the role of complement C5a receptor, C5aR1, in the progression and metastasis of cSCC. C5aR1 expression was increased in cSCC cells in 3D spheroid coculture model in the presence of fibroblasts, and that treatment with recombinant C5a enhanced
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Epidemiological Study and Analysis of Factors Related to Skin Lesions Caused by Medical Disinfectants, and Personal Protective Equipment among Epidemic-Prevention Workers During the SARS-CoV-2 Pandemic Lockdown Period medRxiv. Dermatol. Pub Date : 2024-08-19 Hu Jingyi, Xiu-Li Xiao, Yi Lu, Jian-Yong Su, Yan Zhang, Ting Shang, Chun-Hua Zhang, Lian Guo, Jian-Chao Wang
Objective: The aim of this study was to investigate the prevalence of and potential risk factors associated with skin lesions resulting from the use of medical disinfectants and personal protective equipment (PPE) among epidemic prevention workers (including healthcare professionals, temporary sampling site workers, community members and volunteers) during the Severe Acute Respiratory Syndrome Coronavirus
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Topical Probiotics Decrease the Severity of Atopic Dermatitis. A Systematic Review and Meta-Analysis of Double-Blind, Randomized, Placebo Control Trials medRxiv. Dermatol. Pub Date : 2024-08-01 Elliot Flint, Nabeel Ahmad, Kevin Rowland, Charles Hildebolt, David M Raskin
Atopic Dermatitis (AD) is a chronic skin disease that commonly appears during childhood but can present at any age. There are many reports showing that probiotics relieve AD symptoms in children. This systematic review and meta-analysis sought to determine the efficacy of topical probiotic treatment for AD in adult populations. A database search was conducted of peer-reviewed, double-blind clinical
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Individualized melanoma risk prediction using machine learning with electronic health records medRxiv. Dermatol. Pub Date : 2024-07-27 Guihong Wan, Sara Khattab, Katie Roster, Nga Nguyen, Boshen Yan, Hannah Rashdan, Hossein Estiri, Yevgeniy R. Semenov
Background: Melanoma is a lethal form of skin cancer with a high propensity for metastasizing, making early detection crucial. This study aims to develop a machine learning model using electronic health record data to identify patients at high risk of developing melanoma to prioritize them for dermatology screening. Methods: This retrospective study included patients diagnosed with melanoma (cases)
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A postzygotic GNA13 variant upregulates the RHOA/ROCK pathway and alters melanocyte function in a mosaic skin hypopigmentation syndrome medRxiv. Dermatol. Pub Date : 2024-07-24 Rana El Masri, Alberto Iannuzzo, Paul Kuentz, Rachida Tacine, Marie Vincent, Sebastien Barbarot, Fanny Morice-Picard, Franck Boralevi, Naia Oillarburu, Juliette Mazereeuw-Hautier, Yannis Duffourd, Laurence Faivre, Arthur Sorlin, Pierre Vabres, Jerome Delon
The genetic bases of mosaic pigmentation disorders have increasingly been identified, but these conditions remain poorly characterised, and their pathophysiology is unclear. Here, we report in four unrelated patients that a recurrent postzygotic mutation in GNA13 is responsible for a recognizable syndrome with hypomelanosis of Ito associated with developmental anomalies. GNA13 encodes Galpha13, a subunit
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Gut microbiome and lichen sclerosus: a two-sample bi-directional Mendelian randomization study medRxiv. Dermatol. Pub Date : 2024-07-24 Jun Hu, Jiayan Chen, Peiyan Wang, Changji Xiao, Kalibinuer Kelaimu, Xianshu Gao, Xiaomei Li
(1) Background: Recent studies suggest a potential link between gut microbiomes (GMs) and inflammatory diseases, but the role of GMs in lichen sclerosus (LS) remains unclear. This study aims to investigate the causal relationship between GMs and LS, focusing on key GM taxa. (2) Methods: We utilized GWAS summary statistics for 211 GM taxa and their association with 2,445 LS patients and 353,088 healthy
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Identification and characterization of collagen XXIII alpha 1 as a novel risk factor for eczema herpeticum medRxiv. Dermatol. Pub Date : 2024-07-19 Shruti Chopra, Lennart M. Roesner, Katinka Döhner, Jana Zeitvogel, Stephan Traidl, Elke Rodriguez, Inken Harder, Lieb Wolfgang, Stephan Weidinger, Thomas F. Schulz, Beate Sodeik, Thomas Werfel
Eczema herpeticum (EH) is a potentially life-threatening disseminated skin infection caused by herpes simplex virus (HSV) in a subset of patients with atopic dermatitis (AD). Genetic factors play a pivotal role in EH development. Herein, we identify a single nucleotide polymorphism (SNP) rs2973744 in the gene encoding collagen XXIII alpha 1 chain (Col23a1) as a novel genetic risk factor for EH using
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Radiation sensitivity and efficacy in aggressive and non-aggressive basal cell carcinoma (BCC) of the skin: Image Guided Superficial Radiation Therapy achieves high rate of local control in sclerosing, infiltrative, morpheaform and micronodular BCC subtypes as well as in non high risk BCCs, an analysis of 7994 BCC lesions. medRxiv. Dermatol. Pub Date : 2024-07-18 Lio Yu, Michael Kaczmarski, Clay Cockerell
Background High risk (HR) basal cell carcinoma (BCC) subtypes have been associated with high recurrence rates that is felt to be better managed surgically. Specifically, Mohs Micrographic Surgery (MMS) is considered most effective for aggressive HR BCCs and superior to traditional nonsurgical techniques, including radiation. Recently, superficial radiation therapy with high resolution ultrasound image
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Gasdermin D-Mediated Neutrophil Pyroptosis drives Inflammation in Psoriasis medRxiv. Dermatol. Pub Date : 2024-07-11 Jian Liu, YuYing Jiang, ZiYue Diao, DanDan Chen, RuiYuan Xia, BingWei Wang, Shuo Yang, ZhiQiang Yin
Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated cell death associated with innate immunity, but its role in psoriasis is unclear. In this study, we found that gasdermin D (Gsdmd) is higher in human psoriatic skin than that in normal skin, and in imiquimod-induced
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Exploring Interaction Between Genetically Predicted Body Mass Index and Serum 25-hydroxyvitamin D Levels on the Odds for Psoriasis in UK Biobank and the HUNT Study: A Factorial Mendelian Randomisation Study medRxiv. Dermatol. Pub Date : 2024-07-03 Marita Jenssen, Nikhil Arora, Mari Loset, Bjorn Olav Asvold, Laurent Thomas, Ole-Jorgen Gangso Bekkevold, Xiao-Mei Mai, Yi-Qian Sun, Anne-Sofie Furberg, Rolf Jorde, Tom Wilsgaard, Kjersti Danielsen, Ben M Brumpton
Background: Mendelian randomisation (MR) studies show that higher body mass index (BMI) and lower 25-hydroxyvitamin D (25[OH]D) increase psoriasis risk. The combined effect of these factors has not been explored using factorial MR. Methods: Using cross-sectional data from UK Biobank (UKB, n=398 404) and the Troendelag Health Study (HUNT, n=86 648), we calculated polygenic risk scores for BMI and 25(OH)D
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Multimodal Image Dataset for AI-based Skin Cancer (MIDAS) Benchmarking medRxiv. Dermatol. Pub Date : 2024-06-28 Albert S Chiou, Jesutofunmi A Omiye, Haiwen Gui, Susan M Swetter, Justin M Ko, Brian Gastman, Joshua Arbesman, Zhou Ran Cai, Olivier Gevaert, Chris Sadee, Veronica M Rotemberg, Seung Seog Han, Philipp Tschandl, Meghan Dickman, Elizabeth Bailey, Gordon H Bae, Philip Bailin, Jennifer Boldrick, Kiana Yekrang, Peter Caroline, Jackson Hanna, Nicholas R Kurtansky, Jochen Weber, Niki A See, Michelle Phung
With an estimated 3 billion people globally lacking access to dermatological care, technological solutions leveraging artificial intelligence (AI) have been proposed to improve access. Diagnostic AI algorithms, however, require high-quality datasets to allow development and testing, particularly those that enable evaluation of both unimodal and multimodal approaches. Currently, the majority of dermatology
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Assessment of Ultraviolet and Infrared Radiations Transmission in Automobile Windshields and Side Windows medRxiv. Dermatol. Pub Date : 2024-05-28 Nouf Jubran AlQahtani, Ghada Naje AlEssa, Hoor Fayez AlDushaishi, Amnah Nabil Bukair, Syed Mehmood Ali
Background Although exposure to solar radiation is beneficial for humans, too much of it can cause severe health conditions, including sunburn and skin cancer. The biological effects of solar radiation vary enormously with wavelength and exposure time. Ultraviolet and infrared radiations are the two main invisible components of solar radiation, causing skin damage. People are becoming more aware of
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Enhancing Healthcare Accessibility: A Comprehensive Usability Study of Pathpoint® eDerma Software medRxiv. Dermatol. Pub Date : 2024-05-18 Balamurugan Subramaniyan, Atlas Naqvi, Muna Mohamud, Piyush Mahapatra
This research presents a comprehensive usability evaluation of Pathpoint® eDerma Software, conducted in accordance with IEC 62366-1:2015 standards. The study encompasses four diverse user groups, that includes administrators, medical photographers, dermatologists, and patients, ensuring a holistic assessment of the software’s usability and effectiveness. Through a combination of quantitative metrics
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Toward personalized skin cancer care: multiple skin cancer development in five cohorts medRxiv. Dermatol. Pub Date : 2024-05-07 Lee Wheless, Kai-Ping Liao, Siwei Zheng, Yao Li, Lydia Yao, Yaomin Xu, Christopher Madden, Jacqueline Ike, Isabelle T Smith, Dominique Mosley, Sarah Grossarth, Rebecca I Hartman, Otis Wilson, Adriana Hung, Mackenzie R Wehner
Importance Many patients will develop more than one skin cancer, however most research to date has examined only case status.
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Bactogram: Spatial Analysis of Bacterial Colonization in Epidermal Wounds medRxiv. Dermatol. Pub Date : 2024-04-19 Karl Wallblom, Fredrik Forsberg, Sigrid Lundgren, Jane Fisher, José Cardoso, Ganna Petruk, Ann-Charlotte Strömdahl, Karim Saleh, Manoj Puthia, Artur Schmidtchen
Skin barrier damage and subsequent development of harmful microbiota contribute to conditions such as wound infections, atopic dermatitis, and chronic wounds, which impact millions of people globally and pose a significant economic burden on healthcare systems. Established microbial sampling methods, such as swabs and tissue biopsies, provide limited information on the spatial distribution of bacteria
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Topical Steroid Withdrawal is a Targetable Excess of Mitochondrial NAD+ medRxiv. Dermatol. Pub Date : 2024-04-19 Nadia Shobnam, Sarini Saksena, Grace Ratley, Manoj Yadav, Prem Prashant Chaudhary, Ashleigh A Sun, Katherine N Howe, Manasi Gadkari, Luis M Franco, Sundar Ganesan, Katelyn J McCann, Amy P Hsu, Kishore Kanakabandi, Stacy Ricklefs, Justin Lack, Weiming Yu, Morgan Similuk, Magdalena A Walkiewicz, NIAID Centralized Sequencing Program, Donna D Gardner, Kelly Barta, Kathryn Tullos, Ian A Myles
Background Topical corticosteroids (TCS) are first-line therapies for numerous skin conditions. Topical Steroid Withdrawal (TSW) is a controversial diagnosis advocated by patients with prolonged TCS exposure who report severe systemic reactions upon treatment cessation. However, to date there have been no systematic clinical or mechanistic studies to distinguish TSW from other eczematous disorders
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Assessing GPT-4’s Diagnostic Accuracy with Darker Skin Tones: Underperformance and Implications medRxiv. Dermatol. Pub Date : 2024-04-19 Edgar Akuffo-Addo, Luna Samman, Leena Munawar, Maya Akbik, Nelly Kokikian, Raquel Wescott, Jashin J. Wu
Introduction Conversational artificial intelligence (AI) language models like ChatGPT have emerged as promising tools for patients seeking medical information and guidance. However, their use raises ethical concerns due to the potential for inaccurate medical advice that could harm patients. Previous studies in dermatological machine-learning have highlighted that the underrepresentation of diverse
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Discovering mechanisms underlying medical AI prediction of protected attributes medRxiv. Dermatol. Pub Date : 2024-04-12 Soham Gadgil, Alex J. DeGrave, Roxana Daneshjou, Su-In Lee
Recent advances in Artificial Intelligence (AI) have started disrupting the healthcare industry, especially medical imaging, and AI devices are increasingly being deployed into clinical practice. Such classifiers have previously demonstrated the ability to discern a range of protected demographic attributes (like race, age, sex) from medical images with unexpectedly high performance, a sensitive task
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Highlighting Educational Gaps in Hairstyling Practices amongst Dermatologists and Trainees medRxiv. Dermatol. Pub Date : 2024-03-28 Erinolaoluwa Araoye, Taylor Jamerson, Lu Yin, Kristen Lo Sicco, Crystal Aguh
Background Hairstyling practices are associated with the development and/or exacerbation of various forms of alopecia. Exposure to various hairstyling practices ranges but is often insufficient in current dermatologic textbooks and training curricula. We therefore conducted a survey to establish dermatologists understanding of hairstyling practices, particularly those that have been implicated in alopecia
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Protocol: Trust Your Gut: An Analysis of Dermatologic Diagnostic Accuracy medRxiv. Dermatol. Pub Date : 2024-03-28 Dana Jolley, Varshita Chirumamilla, Abraham Korman
Background: The current clinical misdiagnosis rate among all medical specialties is approximately 10-15%, but diagnostic error within the field of dermatology has not been studied thoroughly1,2. As a field that relies heavily on visual perception, many physicians consider clinical intuition to be advantageous in diagnosing skin diseases and consider it to be a rapid and unconscious phenomenon7. Therefore
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Proteomics data in vitiligo: a scoping review medRxiv. Dermatol. Pub Date : 2024-02-27 Danique Berrevoet, Filip Van Nieuwerburgh, Dieter Deforce, Reinhart Speeckaert
An unbiased screening of which proteins are deregulated in vitiligo using proteomics can offer an enormous value. It could not only reveal robust biomarkers for detecting disease activity but can also identify which patients are most likely to respond to treatments. We performed a scoping review searching for all articles using proteomics in vitiligo. Eight manuscripts could be identified. Unfortunately
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A Randomized Controlled Double-Blinded Split-Face Prospective Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Novel 3-Step Routine Compared to Benzyl Peroxide for the Treatment of Mild to Moderate Acne Vulgaris medRxiv. Dermatol. Pub Date : 2024-02-11 Alison Gern, Steve Xu, Jessica Walter, Paras Vakharia
Adult acne vulgaris affects up to 43-51% of individuals. While there are numerous treatment options for acne including topical, oral, and energy-based approaches, benzoyl peroxide (BPO) is a popular over the counter (OTC) treatment. Although BPO monotherapy has a long history of efficacy and safety, it suffers from several disadvantages, most notably, skin irritation, particularly for treatment naive
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Prevalence of ocular manifestations in cutaneous rosacea: Protocol for a systematic review and meta-analysis medRxiv. Dermatol. Pub Date : 2024-02-01 Kristina Nazzicone, Ryan H. Kirkpatrick, Aleksandar Biorac, Anneke R. Froentjes, Sonja Molin, Sarah Simpson
Introduction: Rosacea is a chronic inflammatory skin condition with concomitant ocular manifestations and neurogenic symptoms. Ocular rosacea poses a particular diagnostic challenge as its signs and symptoms often overlap with other ocular pathologies. Cutaneous and ocular rosacea present together in approximately 21-50% of patients, yet a solid understanding of comorbid ocular and cutaneous symptoms
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Whole Exome and Transcriptome Sequencing of Stage-Matched, Outcome-Differentiated Cutaneous Squamous Cell Carcinoma Identifies Gene Expression Patterns Associated with Metastasis and Poor Outcomes medRxiv. Dermatol. Pub Date : 2024-02-06 Shams Nassir, Miranda Yousif, Xing Li, Kevin Severson, Alysia Hughes, Jacob Kechter, Angelina Hwang, Blake Boudreaux, Puneet Bhullar, Nan Zhang, Duke Butterfield, Tao Ma, Ewoma Ogbaudu, Collin M Costello, Steven Nelson, David J DiCaudo, Aleksandar Sekulic, Christian Baum, Mark Pittelkow, Aaron R Mangold
Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in humans and kills as many people annually as melanoma. The mutational and transcriptional landscape of cSCC has identified driver mutations associated with disease progression as well as key pathway activation in the progression of pre-cancerous lesions. The understanding of the transcriptional changes with respect to high-risk
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Evaluating the Diagnostic and Treatment Recommendation Capabilities of GPT-4 Vision in Dermatology medRxiv. Dermatol. Pub Date : 2024-01-26 Abhinav Pillai, Sharon Parappally-Joseph, Jori Hardin
Background: The integration of artificial intelligence (AI) in dermatology presents a promising frontier for enhancing diagnostic accuracy and treatment planning. However, general purpose AI models require rigorous evaluation before being applied to real-world medical cases. Objective: This project specifically evaluates GPT-4V's performance in accurately diagnosing and generating treatment plans for
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Guidelines For Rigorous Evaluation of Clinical LLMs For Conversational Reasoning medRxiv. Dermatol. Pub Date : 2024-01-23 Shreya Johri, Jaehwan Jeong, Benjamin A. Tran, Daniel I. Schlessinger, Shannon Wongvibulsin, Zhuo Ran Cai, Roxana Daneshjou, Pranav Rajpurkar
The integration of Large Language Models (LLMs) like GPT-4 and GPT-3.5 into clinical diagnostics has the potential to transform patient-doctor interactions. However, the readiness of these models for real-world clinical application remains inadequately tested. This paper introduces the Conversational Reasoning Assessment Framework for Testing in Medicine (CRAFT-MD), a novel approach for evaluating
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Data-driven personalised recommendations for eczema treatment using a Bayesian model of severity dynamics medRxiv. Dermatol. Pub Date : 2024-01-22 Guillem Hurault, Jean Francois Stalder, Marketa Saint Aroman, Reikoko J Tanaka
Atopic dermatitis (AD) is a chronic inflammatory skin disease. AD has heterogeneous phenotypes, making it challenging to predict treatment effects for each patient and to generate personalised treatment recommendations. Here we aim to develop a computational model that predicts the evolution of AD severity and generates treatment recommendations for individual patients. We modelled the temporal evolution
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Wei Ren Anti-Wart Formula combined with photodynamic therapy for Condyloma acuminate: a double-blind, randomized, parallel-group trial medRxiv. Dermatol. Pub Date : 2024-01-11 ShiYan Yang, Liang Hua, Dongjie Guo, Yifei Wang, Xuqiang Wei, Fulun Li
Introduction Condyloma acuminate (CA) is a chronic disease with a high rate of recurrence which has a detrimental impact on patients’ physical and mental health, as well as their quality of life and socioeconomic advancement. Photodynamic therapy is a less invasive and selective intervention for CA, but its safety and high price limit its utilization. Wei Ren Anti-Wart Formula (WRAWF), is a promising
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Oral Baricitinib in the Treatment of Cutaneous Lichen Planus medRxiv. Dermatol. Pub Date : 2024-01-11 Angelina Hwang, Jacob Kechter, Tran Do, Alysia Hughes, Nan Zhang, Xing Li, Rachael Wasikowski, Caitlin Brumfiel, Meera Patel, Blake Boudreaux, Puneet Bhullar, Shams Nassir, Miranda Yousif, David J DiCaudo, Jennifer Fox, Mehrnaz Gharaee-Kermani, Xianying Xing, Samantha Zunich, Emily Branch, J. Michelle Kahlenberg, Allison C. Billi, Olesya Plazyo, Lam C. Tsoi, Mark R Pittelkow, Johann E. Gudjonsson,
Background Cutaneous lichen planus (LP) is a recalcitrant, difficult-to-treat, inflammatory skin disease characterized by pruritic, flat-topped, violaceous papules on the skin. Baricitinib is an oral Janus kinase (JAK) 1/2 inhibitor that interrupts the signaling pathway of interferon (IFN)-γ, a cytokine implicated in the pathogenesis of LP.
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Preliminary Analysis of the Melanoma Multimedia Educational programme for general practitioners on behalf of the Italian Melanoma Intergroup medRxiv. Dermatol. Pub Date : 2023-12-29 Federica Zamagni, Fabio Falcini, Serena Magi, Lauro Bucchi, Silvia Mancini, Rosa Vattiato, Emanuele Crocetti, Stefano Falcinelli, Claudio Feliciani, Maurizio Lombardo, Davide Melandri, Patrizia Re, Francesco Ricci, Rosanna Rita Satta, Sara Gandini, Ignazio Stanganelli, FAD MelaMEd Working Group
Introduction According to the National Oncological Plan 2023-2027 on the importance of multidisciplinary and interactive e-learning training, the Italian Melanoma Intergroup (IMI) has developed MelaMEd (Melanoma Multimedia Education), a national project for general practitioners (GPs) on the prevention and detection of cutaneous melanoma through an online platform and an online course. MelaMEd enables
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Evaluation of a training course for general practitioners within the Melanoma Multimedia Education Programme of the Italian Melanoma Intergroup: study protocol medRxiv. Dermatol. Pub Date : 2023-12-29 Ignazio Stanganelli, Serena Magi, Lauro Bucchi, Emanuele Crocetti, Silvia Mancini, Rosa Vattiato, Stefano Falcinelli, Patrizia Re, Davide Melandri, Marco Brusasco, Sara Gandini, Fabio Falcini, Federica Zamagni, the FAD MelaMEd Working Group
The text discusses the role of general practitioners (GPs) in the prevention and early diagnosis of melanoma, a type of skin cancer. It highlights the need for GPs to be able to recognize suspicious skin lesions and refer patients to specialist dermatology centers. However, many GPs lack comprehensive training in diagnosing melanoma. The text mentions that various training courses have been conducted
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Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing medRxiv. Dermatol. Pub Date : 2023-12-09 Sigrid Lundgren, Ganna Petruk, Karl Wallblom, José FP Cardoso, Ann-Charlotte Strömdahl, Fredrik Forsberg, Congyu Luo, Bo Nilson, Erik Hartman, Jane Fisher, Manoj Puthia, Karim Saleh, Artur Schmidtchen
The skin microbiome undergoes dynamic changes during different phases of wound healing, however the role of bacteria in the wound healing process remains poorly described. In this study, we aimed to determine how wound bacteria develop over time in epidermal wounds, and how they interact with inflammatory processes during wound healing. To this end, we analyzed wound fluid and swab samples collected
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Association between Stevens-Johnson syndrome and toxic epidermal necrolysis with ibuprofen: A pharmacovigilance study in the UK Yellow Card scheme and systematic review of case reports medRxiv. Dermatol. Pub Date : 2023-12-07 Guy Fletcher, David K. Ryan, C B. Bunker
Introduction Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a group of severe acute muco-cutaneous blistering disorders with a significant burden of morbidity and mortality. Drugs are commonly identified as potential precipitants of SJS/TEN, although it can be difficult to firmly identify causative agents. Ibuprofen has been proposed as a rare trigger for SJS/TEN and given
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A Convolutional Neural Network based system for classifying malignant and benign skin lesions using mobile-device images medRxiv. Dermatol. Pub Date : 2023-12-06 Rim Mhedbi, Peter Credico, Hannah O. Chan, Rakesh Joshi, Joshua N. Wong, Colin Hong
The escalating incidence of skin lesions, coupled with a scarcity of dermatologists and the intricate nature of diagnostic procedures, has resulted in prolonged waiting periods. Consequently, morbidity and mortality rates stemming from untreated cancerous skin lesions have witnessed and upward trend. To address this issue, we propose a skin lesion classification model that leverages EfficientNet B7
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Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent medRxiv. Dermatol. Pub Date : 2023-12-04 Li Li, Irshad Hajam, Jean S McGee, Zhengkuan Tang, Ye Zhang, Nikil Badey, Esther Mintzer, Zhenrui Zhang, George Y Liu, George Church, Yu Wang
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular
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Temporal dynamics of skin microbiota and immune correlates in psoriasis patients receiving systemic treatment medRxiv. Dermatol. Pub Date : 2023-11-27 Su-Hsun Liu, Yu-Huei Huang, Hao-Jui Weng, Tsen-Fang Tsai, Huang-Yu Yang, Leslie Y Chen, Yen-Ling Chiu, Hsiao-Yun Yu, Yi-Chieh Chiu, Chao-Yu Ng, Ya-Ching Chang, Chung-Yee R Hui, Yhu-Chering Huang
Background How skin microbiota in psoriasis patients responded to systematic therapeutics remained unknown.
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The use of a deep learning model in the histopathological diagnosis of actinic keratosis: A case control accuracy study medRxiv. Dermatol. Pub Date : 2023-11-20 J. Balkenhol, M. Schmidt, T. Schnauder, J. Langhorst, J. Le’Clerc Arrastia, D. Otero Baguer, G. Gilbert, L. Schmitz, T. Dirschka
Actinic Keratosis (AK) is a frequent dermatological diagnosis which contributes to a large proportion of routine dermatopathology. A current development in histopathology is in the digitization of specimens by creating whole slide images (WSI) with slide scanners. Deep Learning Models (DLM) have been introduced to radiology or pathology for image recognition but dermatopathology lacks available solutions
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Single-cell analysis of psoriasis resolution reveals an inflammatory fibroblast state targeted by IL-23 blockade medRxiv. Dermatol. Pub Date : 2023-11-20 Luc Francis, Daniel McCluskey, Clarisse Ganier, Treasa Jiang, Xinyi Du-Harpur, Jeyrroy Gabriel, Pawan Dhami, Yogesh Kamra, Sudha Visvanathan, Jonathan N. Barker, Catherine H. Smith, Francesca Capon, Satveer K. Mahil
Biologics targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis. However, the early mechanisms of action of these drugs remain poorly understood. Here, we performed longitudinal single-cell RNA-sequencing in affected individuals receiving IL-23 inhibitor therapy. By profiling skin at baseline, day 3 and day 14 of treatment, we demonstrated that IL-23 blockade causes marked gene
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An integrated active case search for skin-NTDs in yaws endemic health districts in Cameroon, Côte d’Ivoire and Ghana medRxiv. Dermatol. Pub Date : 2023-11-16 Serges Tchatchouang, Laud A. Basing, Hugues Kouadio-Aboh, Becca L Handley, Camila G-Beiras, Ivy Amanor, Philippe Ndzomo, Mohammed Bakheit, Lisa Becherer, Sascha Knauf, Claudia Müller, Earnest Njih-Tabah, Theophilus Njmanshi, Tania Crucitti, Nadine Borst, Simone Lüert, Sieghard Frischmann, Helena Gmoser, Emelie Landmann, Aboubacar Sylla, Mireille S. Kouamé-Sina, Daniel Arhinful, Patrick Awondo, Gely
Background: Integrated approaches to mapping skin Neglected Tropical Diseases (NTDs) may be cost-effective way to guide decisions on resource mobilization. Pilot studies have been carried out, but large-scale data covering multiple countries endemic for skin-NTDs are lacking. Within the LAMP4YAWS project, we collected integrated data on the burden of multiple skin-NTDs. Methods: From March 2021 to
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Pathophysiological Mechanisms of the Onset, Development, and Disappearance Phases of Skin Eruptions in Chronic Spontaneous Urticaria medRxiv. Dermatol. Pub Date : 2023-11-12 Sungrim Seirin-Lee, Shunsuke Takahagi, Michihiro Hide
Chronic spontaneous urticaria (CSU) is a typical example of an intractable skin dis- ease with no clear cause and significantly affects daily life of patients. Because CSU is a human-specific disease and lacks proper animal model, there are many questions regarding its pathophysiological dynamics. On the other hand, most clinical symptoms of urticaria are notable as dynamic appearance of skin eruptions
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Single-cell spatial proteomics identifies the JAK/STAT pathway as an actionable therapeutic target in lethal cutaneous drug reactions medRxiv. Dermatol. Pub Date : 2023-11-12 Thierry Nordmann, Holly Anderton, Akito Hasegawa, Lisa Schweizer, Peng Zhang, Pia-Charlotte Stadler, Ankit Sinha, Andreas Metousis, Florian A. Rosenberger, Maximillian Zwiebel, Takashi K. Satoh, Florian Anzengruber, Maria C. Tanzer, Yuki Saito, Ting Gong, Marvin Thielert, Haruna Kimura, Natasha Silke, Edwin H. Rodriguez, Restivo Gaetana, Hong Ha Nguyen, Annette Gross, Mitchell P. Levesque, Peter J
Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction and an emerging public health issue. Triggered by common medications, TEN patients undergo severe and sudden epidermal detachment caused by keratinocyte cell death. Although molecular mechanisms driving keratinocyte cell death have been proposed, the main drivers remain unknown and no effective therapy exists. To systematically
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Meta-analysis of RNA sequencing data from 534 skin samples shows substantial IL-17 effects in non-lesional psoriatic skin medRxiv. Dermatol. Pub Date : 2023-11-04 Åshild Øksnevad Solvin, Konika Chawla, Marita Jenssen, Lene Christin Olsen, Anne-Sofie Furberg, Kjersti Danielsen, Marit Saunes, Kristian Hveem, Pål Sætrom, Mari Løset
Psoriasis is a common chronic inflammatory skin disease characterized by disturbed interactions between infiltrating immune cells and keratinocytes. To enhance our understanding of the underlying molecular and cellular mechanisms driving psoriasis pathobiology, and to identify potential biomarkers for disease severity, we conducted RNA sequencing of skin biopsies from 75 patients with psoriasis vulgaris
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Diabetes, glycemic profile and risk of vitiligo: a Mendelian randomization study medRxiv. Dermatol. Pub Date : 2023-10-30 Shucheng Hu, Yuhui Che, Jiaying Cai, Jing Guo, Jinhao Zeng
Objectives: Previous observational studies have shown that vitiligo usually co-manifests with a variety of dysglycemic diseases, such as Type 1 diabetes mellitus(T1DM) and Type 2 diabetes mellitus(T2DM). Mendelian randomization analysis was performed to further evaluate the causal association between fasting plasma glucose, glycosylated hemoglobin(HbA1c),T1DM,T2DM and vitiligo.Methods:We used aggregated
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Predicting skin cancer risk from facial images with an explainable artificial intelligence (XAI) based approach: a proof-of-concept study medRxiv. Dermatol. Pub Date : 2023-10-05 Xianjing LIU, Tobias E. Sangers, Tamar Nijsten, Manfred Kayser, Luba Pardo-Cortes, Eppo Wolvius, Gennady V Roshchupkin, Marlies Wakkee
Background: Efficient identification of individuals at high risk of skin cancer is crucial for implementing personalized screening strategies and subsequent care. While Artificial Intelligence holds promising potential for predictive analysis using image data, its application for skin cancer risk prediction utilizing facial images remains unexplored. We present a neural network-based explainable artificial
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Somatic mutations reveal hyperactive Notch signaling and racial disparities in prurigo nodularis medRxiv. Dermatol. Pub Date : 2023-09-26 Ahmad Rajeh, Hannah L Cornman, Anuj Gupta, Mindy D Szeto, Anusha Kambala, Olusola Oladipo, Varsha Parthasarathy, Junwen Deng, Sarah Wheelan, Thomas Pritchard, Madan M Kwatra, Yevgeniy R Semenov, Alexander Gusev, Srinivasan Yegnasubramanian, Shawn G Kwatra
Prurigo nodularis (PN) is a chronic inflammatory skin disease that disproportionately affects African Americans and is characterized by pruritic skin nodules of unknown etiology. Little is known about genetic alterations in PN pathogenesis, especially relating to somatic events which are often implicated in inflammatory conditions. We thus performed whole-exome sequencing on 54 lesional and nonlesional
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Pre-trained Multimodal Large Language Model Enhances Dermatological Diagnosis using SkinGPT-4 medRxiv. Dermatol. Pub Date : 2023-09-06 Juexiao Zhou, Xiaonan He, Liyuan Sun, Jianan Xu, Xiuying Chen, Yuetan Chu, Longxi Zhou, Xingyu Liao, Bin Zhang, Xin Gao
Large language models (LLMs) are seen to have tremendous potential in advancing medical diagnosis recently. However, it is important to note that most current LLMs are limited to text interaction alone. Meanwhile, the development of multimodal large language models for medical diagnosis is still in its early stages, particularly considering the prevalence of image-based data in the field of medical
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Pre-Existing Inflammatory Disease Predicts Cutaneous Immunotherapy Toxicity Development: A Multi-Institutional Cohort Study medRxiv. Dermatol. Pub Date : 2023-08-29 Guihong C. Wan, Nga Nguyen, Bonnie W. Leung, Hannah Rashdan, Kimberly Tang, Katie Roster, Michael R. Collier, Pearl O. Ugwu-Dike, Neel S. Raval, Nora A. Alexander, Ruple Jairath, Jordan Phillipps, Munachimso Amadife, Shijia Zhang, Alexander Gusev, Steven T. Chen, Kerry L. Reynolds, Nicole R. LeBoeuf, Shawn G. Kwatra, Yevgeniy R. Semenov
Background: Relationships between pre-existing inflammatory diseases (pIDs) and cutaneous immune-related adverse events (cirAEs) have not been well-studied. This study is to investigate associations between pIDs and cirAEs among immune-checkpoint inhibitor (ICI) recipients at the Mass General Brigham healthcare system. Methods: Electronic health records were reviewed to ascertain cirAE status. Patients'
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Advancements in Managing Wound Biofilm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Topical Modalities medRxiv. Dermatol. Pub Date : 2023-08-21 Adam Astrada, Rian Adi Pamungkas, Khoirul Rista Abidin
Significance: Gaining insights into the efficacy of topical wound treatments for biofilm eradication is pivotal to enhancing wound management strategies. Despite numerous available agents claiming anti-biofilm properties, the substantiating evidence remains inconclusive. This study aimed to assess the immediate impact of topical wound treatments on wound biofilm and healing outcomes in acute and chronic
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Occupational dermatoses in health care personnel using PPE during the COVID pandemic. medRxiv. Dermatol. Pub Date : 2023-07-16 Dinesh Asati, Kapil Baheti, Maninder Kaur, Suman Patra, Kritika Singhal
Background: A sudden surge of occupation-associated dermatoses among the healthcare workers (HCWs) serving COVID-19 patients have been witnessed recently due to increased usage of PPE (PPE) kits and increased frequency of hygiene practices, with a significant impact on their quality of life and compromised efficacy at work. Hence, this study was conducted to measure the prevalence of occupational dermatoses
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GPT-4, an artificial intelligence large language model,exhibits high levels of accuracy on dermatology specialty certificate exam questions. medRxiv. Dermatol. Pub Date : 2023-07-14 Meghna Shetty, Michael Ettlinger, Magnus Lynch
Artificial Intelligence (AI) has shown considerable potential within medical fields including dermatology. In recent years a new form of AI, large language models, have shown impressive performance in complex textual reasoning across a wide range of domains including standardised medical licensing exam questions. Here, we compare the performance of different models within the GPT family (GPT-3, GPT-3
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Targeting of Th17-related cytokines in patients with Darier Disease medRxiv. Dermatol. Pub Date : 2023-07-05 Monika Ettinger, Teresa Burner, Anshu Sharma, Yun-Tsan Chang, Angelika Lackner, Pacome Prompsy, Isabella Deli, Judith Traxler, Gerald Wahl, Sabine Altrichter, Yi-Chien Tsai, Suraj R Varkhande, Leonie Christine Schoeftner, Christoph Iselin, Iris K Gratz, Susanne Kimeswenger, Emmanuella Guenova, Wolfram Hoetzenecker
Darier disease (DD) is a rare, inherited multi-organ disorder associated with mutations in the ATP2A2 gene. DD patients often have skin involvement characterized by malodorous, inflamed skin and recurrent, severe infections. Therapeutic options are limited and inadequate for the long-term management of this chronic disease. Using gene and protein expression profiling assays, we demonstrate enhanced
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The effect of natural terrestrial gamma radiation emissions and environmental radon levels on the incidence of cutaneous squamous cell carcinoma of the head and neck. medRxiv. Dermatol. Pub Date : 2023-06-28 Iván Couto-Gonzalez, Jorge Arenaz-Búa, Antonio Taboada-Suárez, Abel García-García
The effects of ionising radiation on the development of cutaneous squamous cell carcinoma have been previously studied in environments in which the levels of ionising radiation have been increased by artificial sources. The purpose of this study is to determine the role that environmental radon concentration and natural gamma radiation emissions may play in the development of head and neck cutaneous
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Phenome-wide association of acne susceptibility loci highlights shared and unique biology medRxiv. Dermatol. Pub Date : 2023-06-20 Minsoo Kim, Carol E Cheng
The latest genome-wide association studies (GWAS) comprising 20,165 acne cases and 595,231 controls have successfully identified 42 genomic regions associated with increased risk of acne. Yet, it remains unclear the extent to which these individual acne susceptibility loci contribute to other disorders. To begin to identify shared and unique biology underlying acne pathogenesis, we conducted phenome-wide