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Predictive factors for tuberculous peripheral pulmonary lesions during radial endobronchial ultrasound Resp. Med. (IF 3.5) Pub Date : 2024-09-13 Sze Shyang Kho, Swee Kim Chan, Siew Teck Tie
Tuberculosis frequently poses diagnostic challenge when it presents as a peripheral pulmonary lesion (TB-PPL). The growing use of radial endobronchial ultrasound (rEBUS) for PPL biopsy highlights the need to identify predictive factors for TB-PPL, which is crucial for procedure safety. A six-year retrospective review at our institution on adult patients with TB and malignant-PPL diagnosed from rEBUS
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Is it worth screening quarry workers for TB infection in high-incidence areas? A cost-benefit analysis Resp. Med. (IF 3.5) Pub Date : 2024-09-11 Sofia Sousa, Carlos Carvalho, Sofia Santos, Catarina Magalhães Alves, Guilherme Gonçalves, Álvaro Almeida, Raquel Duarte
Tuberculosis (TB) infection screening of high-risk groups is an important strategy for achieving End TB targets. A TB infection screening program was implemented for quarry workers from a Portuguese high-incidence area in 2018–2022. We aimed to calculate the cost-benefit of the screening program from the societal perspective. We calculated medical and non-medical direct and indirect screening costs
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Preserved ratio impaired spirometry and severity of obstructive sleep apnea: An observational cross-sectional study Resp. Med. (IF 3.5) Pub Date : 2024-09-11 Hiroaki Ogata, Hiroshi Nakano, Toyoshi Yanagihara, Yuki Moriuchi, Aimi Enokizu-Ogawa, Akiko Ishimatsu, Junji Otsuka, Tomokazu Furukawa, Kazuhito Taguchi, Atsushi Moriwaki, Makoto Yoshida
Lung function abnormality of obstructive sleep apnea (OSA) has not been explored well. Preserved ratio impaired spirometry (PRISm) is known for its association with obesity and cardiovascular morbidity, which are also characteristic features of OSA. This study aims to investigate whether the prevalence of PRISm increases according to apnea–hypopnea index levels among subjects with OSA. Conducted as
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Temporal variation in the effectiveness of biologics in asthma: Effect modification by changing patient characteristics Resp. Med. (IF 3.5) Pub Date : 2024-09-10 Tanawin Nopsopon, Alyson Brown, Georg Hahn, Matthew Rank, Krista F. Huybrechts, Ayobami Akenroye
The underlying population of patients selected for each respiratory monoclonal antibody might change as other biologics are approved. To evaluate effect modification by calendar time of the effectiveness of each respiratory biologics in asthma. The Effectiveness of Respiratory biologics in Asthma (ERA) is a retrospective cohort of severe asthma patients from the Mass General Brigham clinics between
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Short- and long-term clinical outcomes of nintedanib therapy in IPF patients with different phenotypes: A retrospective registry-based study Resp. Med. (IF 3.5) Pub Date : 2024-09-08 Martina Koziar Vašáková, Jakub Gregor, Nesrin Mogulkoc, Mordechai R. Kramer, Katarzyna Lewandowska, Martina Šterclová, Veronika Müller, Róbert Slivka, Michael Studnicka, Martina Plačková, Monika Žurková, Jasna Tekavec-Trkanjec, Martina Doubková, Petra Ovesná, on behalf of EMPIRE investigators
There is a lack of data on the long-term effect of nintedanib on survival in specific groups of idiopathic pulmonary fibrosis (IPF) patients with different phenotypes. We investigated the outcomes of nintedanib therapy in an observational study of a large multicentre real-world cohort of IPF patients with various initial characteristics. The analysis included IPF patients treated with nintedanib (NIN)
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Dyspnea in Parkinson's disease Resp. Med. (IF 3.5) Pub Date : 2024-09-07 Suyash Jain, Shruti Patel, Kenneth Nugent
Dyspnea is an important non-motor symptom in Parkinson's disease (PD) that impacts quality of life. The mechanisms underlying dyspnea have been difficult to determine due to challenges separating central respiratory control abnormalities from peripheral respiratory muscle dysfunction and chest wall rigidity. A comprehensive literature review was conducted, searching the PubMed database for observational
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A nomogram for predicting short-term mortality in ICU patients with coexisting chronic obstructive pulmonary disease and congestive heart failure Resp. Med. (IF 3.5) Pub Date : 2024-09-07 Qiangqiang Shi, Jiali Xu, Longhuan Zeng, Ziyi Lu, Yang Chen
This study aimed to develop and validate a nomogram for predicting 28-day and 90-day mortality in intensive care unit (ICU) patients who have chronic obstructive pulmonary disease (COPD) coexisting with congestive heart failure (CHF). An extensive analysis was conducted on clinical data from the Medical Information Mart for Intensive Care IV database, covering patients over 18 years old with both COPD
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Effect modification of glycemic control on association of lung function with all-cause and cardiovascular mortality in persons with type 2 diabetes – A retrospective cohort study Resp. Med. (IF 3.5) Pub Date : 2024-09-07 Cheng-Chieh Lin, Chia-Ing Li, Chuan-Wei Yang, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Poor glucose control might deteriorate the impaired pulmonary function, which can ultimately lead to mortality. However, few studies have examined the effect modification of glucose control on the association between pulmonary function and mortality. This study aimed to examine the association of pulmonary function with mortality and determine the effect modification of glycemic level on the association
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Road to referral success in COPD: Enhancing patient engagement through dedicated conversations about pulmonary rehabilitation programs Resp. Med. (IF 3.5) Pub Date : 2024-08-30 Sarah Hug, Vinicius Cavalheri, Kylie Hill, Daniel F. Gucciardi
From the perspectives of healthcare professionals (HCPs) and people with chronic obstructive pulmonary disease (COPD) known to tertiary care, what influences successful referrals to a pulmonary rehabilitation program (PRP)? This cross-sectional qualitative study was informed by a critical realist perspective. We purposively sampled people with COPD and HCPs who deliver COPD care and used semi-structured
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The role of FEV1/FVC in the prediction of acute exacerbation of COPD Resp. Med. (IF 3.5) Pub Date : 2024-08-30 Jong Geol Jang, Youlim Kim, Sun Hye Shin, Kyung Hoon Min, Ki Suck Jung, Yu-il Kim, Shinhee Park, Joo Ock Na, Hyun Lee, Kwang Ha Yoo
Whether the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV/FVC) can be used as a biomarker to predict the risk of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is unclear. To investigate the predictive role of FEV/FVC for AECOPD, we analyzed data from an observational and multicenter cohort study of 2043 patients with COPD in KOREA. Exposures were post-bronchodilator
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Association of computed tomography-derived pectoralis muscle area and density with disease severity and respiratory symptoms in patients with chronic obstructive pulmonary disease: A case-control study Resp. Med. (IF 3.5) Pub Date : 2024-08-27 Can Li, Xinying Lian, Jingchun He, Xiao Gao, Xuehuan Liu, Cuiping Bao, Zuoxi Li, Weiwei Cui, Li Yu, Jun Liu
Computed tomography (CT) is commonly used and offers an additional viewpoint for evaluating extrapulmonary symptoms, disease severity, and muscle atrophy. This study assessed whether the pectoralis muscle area (PMA) and pectoralis muscle density (PMD) are lower in patients with chronic obstructive pulmonary disease (COPD) than in healthy controls and elucidated their relationships with these variables
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Evaluation of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1α) and apelin 13 levels as new potential biomarkers for pulmonary thromboembolism: A prospective clinical study Resp. Med. (IF 3.5) Pub Date : 2024-08-26 Nuruban Delal Baykal, Buket Mermit, Hamit Hakan Alp, Hanifi Yıldız
The objective was to evaluate the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1α), and apelin 13 in patients with acute pulmonary thromboembolism (PE) and to investigate their diagnostic and prognostic role in PE patients with different mortality risk groups. This study was conducted in a tertiary referral center and included 124 subjects with
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Feasibility of remote spirometry monitoring of asthma in pregnancy Resp. Med. (IF 3.5) Pub Date : 2024-08-24 Robert Wharton, Noah Mathis, Jing Gennie Wang, Rachel Meislin, Bian Liu, Najla Abdurrahman, Vi Le, Kevin Rurak, Corrine Hanson, Loretta G. Que, David Shaz, Sonali Bose
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Investigation of pepsin levels in bronchial lavage in patients with interstitial lung disease and chronic cough Resp. Med. (IF 3.5) Pub Date : 2024-08-23 Fatma Selen Ala Çitlak, Nurhan Köksal, Bahattin Avci, Nazmiye Tibel Tuna, Yusuf Taha Güllü
Pepsin is an enzyme that helps digest protein secreted only from the gastric chief cell in an inactive state. Pepsin is a good marker for acidic gastroesophageal reflux (GER). Its presence in sputum or saliva is considered pathologic. In GER, cough is stimulated by broncho-esophageal neurogenic reflex and aspiration of gastric contents into the airways. GER is the most common cause of cough. Gastric
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Current physiotherapy practice for adults with bronchiectasis: Data from the Australian bronchiectasis registry Resp. Med. (IF 3.5) Pub Date : 2024-08-23 Elizabeth M. Webb, Anne E. Holland, Anne B. Chang, Lucy Burr, Chien-Li Holmes-Liew, Paul T. King, Peter G. Middleton, Lucy Morgan, Rachel M. Thomson, Conroy Wong, Annemarie L. Lee
Although airway clearance techniques (ACTs) and physical exercise are recommended for adults with bronchiectasis, there is little data on current practice and limited guidance predicting clinical approach. This study aimed to describe current ACT and exercise practice recorded by patients, and identify predictors of regular ACTs, ACT modalities and exercise. Physiotherapy-specific interventions, quality
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An update on the minimally invasive diagnosis of lymphoma for the chest physicians Resp. Med. (IF 3.5) Pub Date : 2024-08-23 Ronaldo Ortiz-Pacheco, Tejas Sinha, Christian Ghattas, Jasleen Pannu, Jason Willis, Alberto Revelo, Nicholas Pastis
Mediastinal lymphadenopathy has a broad differential diagnosis which includes lymphoma. The current preferred biopsy technique for mediastinal lymph nodes is transbronchial needle aspiration which has mixed results in terms of sensitivity, specificity and diagnostic yields; there are also limitations with subtyping lymphomas with needle aspiration alone which can be a barrier to determine management
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Choosing the right biologic treatment for individual patients with severe asthma – Lessons learnt from Picasso Resp. Med. (IF 3.5) Pub Date : 2024-08-22 Milan Terl, Zuzana Diamant, Radovan Kosturiak, Milos Jesenak
Severe asthma represents a true challenge for clinicians from two basic perspectives, : a rational assessment of the underlying endo/phenotype and the subsequent selection of the best fitted (personalized) and effective treatment. Even though asthma is a heterogeneous disease, in the majority of therapy-compliant patients, it is possible to achieve (almost) complete disease control or even remission
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Prevalence and etiotypes of persistent airflow obstruction in the general population across the lifetime Resp. Med. (IF 3.5) Pub Date : 2024-08-22 M.T. Grasl, A. Agusti, M. Azizzadeh, A. Karimi, S. Hartl, M.-K. Breyer, R. Breyer-Kohansal
Different factors (etiotypes) can lead to persistent airflow obstruction (PAO) across the lifetime, including genetic factors, abnormal lung development, cigarette smoking, traffic pollution exposure, respiratory infections and asthma. Here we explore the prevalence of PAO and associated etiotypes in the general population in different age bins. We studied 664 individuals with PAO (FEV1/FVC post bronchodilation
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Phase angle measured by bioelectrical impedance analysis in patients with chronic obstructive pulmonary disease: Associations with physical inactivity and frailty Resp. Med. (IF 3.5) Pub Date : 2024-08-22 Ryota Hamada, Naoya Tanabe, Yohei Oshima, Yuji Yoshioka, Tomoki Maetani, Yusuke Shiraishi, Atsuyasu Sato, Susumu Sato, Ryosuke Ikeguchi, Shuichi Matsuda, Toyohiro Hirai
Factors associated with early-stage frailty (pre-frailty) in patients with chronic obstructive pulmonary disease (COPD) remain unestablished. In addition to skeletal muscle quantity, skeletal muscle dysfunction can be estimated using an angular metric from bioelectrical impedance analyzer (BIA), termed the phase angle, that reflects cell membrane reactance representing the structural stability. This
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Prevalence and prognostic value of malnutrition in patients with IPF using three scoring systems Resp. Med. (IF 3.5) Pub Date : 2024-08-19 Qinxue Shen, Shiting Zhou, Min Song, Xiaoli Ouyang, Yuexin Tan, Yating Peng, Zijing Zhou, Hong Peng
To describe the nutritional status of IPF patients, report clinical associations and evaluate the prognostic value of them in IPF. 264 IPF patients diagnosed with IPF at the Second Xiangya Hospital of Central South University between January 2011 and January 2021 were recruited. Three different scoring systems, including nutritional risk index (NRI), controlling nutritional status (CONUT) score, and
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Plasma catecholamines in patients undergoing invasive cardiopulmonary exercise test for exercise intolerance Resp. Med. (IF 3.5) Pub Date : 2024-08-13 Abdelrahman Nanah, Marcos V.F. Garcia, James Lane, Deborah Paul, Adriano R. Tonelli
Invasive cardiopulmonary exercise testing (iCPET) combines traditional cardiopulmonary exercise testing with invasive hemodynamic measurements to assess exercise intolerance, which can be caused by preload insufficiency (PI), characterized by low ventricular filling pressures and reduced cardiac output during exertion. We hypothesize that plasma catecholamine levels at rest and during exercise correlate
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Dietary patterns and risk of Chronic Obstructive Pulmonary Disease (COPD) and clinical outcomes in diagnosed patients: A scoping review Resp. Med. (IF 3.5) Pub Date : 2024-08-13 Carolina Ignacio Carlotto, Simone Bernardes, Priscilla Zanella, Flávia Moraes Silva
Limited research exists on the association between dietary patterns (DP) and COPD risk or health-related outcomes. We reviewed existing literature to identify DP as a potential factor influencing COPD development and associated health outcomes in diagnosed individuals. We followed the Joanna Briggs Institute methodology for this scoping review, conducting searches on PubMed, Scopus, Embase, and Web
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The influence of the interventionalist's sex on the outcome and complications of transbronchial lung cryobiopsy Resp. Med. (IF 3.5) Pub Date : 2024-08-13 Franziska C. Trudzinski, Christos Athanasiou, Ralf Eberhardt, Julia D. Michels-Zetsche, Mavi Schellenberg, Monika Eichinger, Markus Polke, Kathrin Kahnert, Felix J.F. Herth, Michael Kreuter, Konstantina Kontogianni
To date there are no data on sex aspects evaluating outcomes of interventional pneumology (IP). Our aim was to investigate sex differences in transbronchial lung cryobiopsy (TBLC) outcomes in the diagnosis of interstitial lung disease (ILD). All consecutive (TBLC)s performed for ILD evaluation between Nov 17 and Dec 21 at a tertiary referral center for ILDs and IP were analyzed. The indication for
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High prevalence of undiagnosed and treatment-requiring obstructive sleep apnea and nocturnal desaturation in outpatients with severe chronic obstructive pulmonary disease Resp. Med. (IF 3.5) Pub Date : 2024-08-12 Kristina Kock Hansen, Ole Hilberg, Anders Løkke
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Prevalence and burden of loneliness in COPD: A systematic review and meta-analysis Resp. Med. (IF 3.5) Pub Date : 2024-08-12 Jaber S. Alqahtani, Abayomi Arowosegbe, Abdulelah M. Aldhahir, Saeed M. Alghamdi, Abdullah A. Alqarni, Rayan A. Siraj, Ibrahim A. AlDraiwiesh, Hassan Alwafi, Tope Oyelade
Loneliness poses significant public health concerns on a global scale. Being alone and lacking social connections have been proven to impact prognosis and response to treatment in different diseases, including COPD. Yet, the prevalence and burden of loneliness on COPD outcomes remain unclear. Various relevant databases were systematically searched in March 2024. The quality of the studies included
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Onion consumption is protective against asthma risk in children: ROAD to health population-based cohort study Resp. Med. (IF 3.5) Pub Date : 2024-08-11 Anna Norweg, Cheongeun Oh, Anna Nolan
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In COPD- right treatment, right patient, right time, right approach? Resp. Med. (IF 3.5) Pub Date : 2024-08-11 Jean Bourbeau
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Comparison of race-specific and race-neutral GLI spirometric reference equations with an Indian reference equation Resp. Med. (IF 3.5) Pub Date : 2024-08-10 Subhabrata Moitra, Ritabrata Mitra, Saibal Moitra
Despite the increasing popularity and use of Global Lung Function Initiative (GLI) spirometric reference equations, the appropriateness of the race-specific and race-neutral GLI spirometric reference models among the Indian population has not been systematically investigated. In this cross-sectional analysis, we used spirometric measurements of 1123 healthy Indian adults (≥18 years of age). We computed
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Short-term intermittent hypoxia exposure for dyspnea and fatigue in post-acute sequelae of COVID-19: A randomized controlled study Resp. Med. (IF 3.5) Pub Date : 2024-08-08 Shiqian Zha, Xu Liu, Yan Yao, Yang He, Yixuan Wang, Qingfeng Zhang, Jingyi Zhang, Yaohua Yi, Rui Xiao, Ke Hu
Post-acute sequelae of COVID-19 (PASC) is incurring a huge health and economic burden worldwide. There is currently no effective treatment or recommended drug for PASC. This prospective randomized controlled study was conducted in a hospital in China. The effect of intermittent hypoxia exposure (IHE; 5-min hypoxia alternating with 5-min normal air, repeated five times) on dyspnea and fatigue was investigated
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Supporting vaccine (co)-administration decisions: Development and validation of a tool for assessing the risk of severe outcomes due to lower respiratory tract infections Resp. Med. (IF 3.5) Pub Date : 2024-08-06 Francesco Lapi, Alexander Domnich, Ettore Marconi, Iacopo Cricelli, Alessandro Rossi, Giancarlo Icardi, Claudio Cricelli
To develop and validate a score to predict the 90-day risk of hospitalization/death in patients with low respiratory tract infections (LRTIs) with the aim to support clinical decision making on vaccine (co)-administration. We formed a cohort of patients aged 18 years or older being diagnosed with LRTIs in the period between January 1, 2012 and December 31, 2022. Each patient was followed until occurrence
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Nasal high flow or noninvasive ventilation? navigating hypercapnic COPD exacerbation treatment: A randomized noninferiority clinical trial Resp. Med. (IF 3.5) Pub Date : 2024-08-05 Ioannis Pantazopoulos, Stylianos Boutlas, Georgios Mavrovounis, Athanasia Papalampidou, Nikolaos Papagiannakis, Marina Kontou, Eleni Bibaki, Nikolaos Athanasiou, Georgios Meletis, Konstantinos Gourgoulianis, Spyros Zakynthinos, Eleni Ischaki
Noninvasive ventilation (NIV) has been the cornerstone for managing acute exacerbations of COPD (AECOPD) with hypercapnic respiratory failure. Nasal high flow (NHF) oxygen therapy has emerged as a potential alternative, offering a more tolerable modality with promising outcomes. The aim of the present study was to evaluate whether NHF respiratory support is noninferior to NIV with respect to treatment
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Efficacy and safety of simultaneous combined Zephyr and Spiration valve therapy in patients with advanced pulmonary emphysema Resp. Med. (IF 3.5) Pub Date : 2024-08-03 A. Susanne Dittrich, Konstantina Kontogianni, Ann-Sophie Unterschemmann, Susanne De Rossi, Franziska Trudzinski, Judith Maria Brock, Daniela Gompelmann, Claus Peter Heussel, Felix J.F. Herth, Ralf Eberhardt
Endoscopic lung volume reduction with valves is a minimally invasive treatment strategy for patients with severe pulmonary emphysema. Two valve systems are currently available: Zephyr and Spiration valves. As these can be implanted simultaneously in the same procedure, the question arose as to the effect on lung function, exercise capacity and subjective disease perception after combined valve treatment
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Impact of the quantity and quality of erector spinae muscles on the short-term prognosis of elderly patients with aspiration pneumonia in Japan Resp. Med. (IF 3.5) Pub Date : 2024-08-03 Yuichi Murakawa, Akira Tamaki, Ryota Matsuzawa, Shinjiro Miyazaki, Tatsuma Hori, Miki Naide, Kenichiro Sakai
Whether muscle mass and muscle quality affect the prognosis of elderly patients with aspiration pneumonia is unclear. This study aimed to evaluate the relationship between erector spinae muscle mass and muscle quality on the 30-day prognosis of elderly patients with aspiration pneumonia. Two hundred fifty-eight patients who were diagnosed with aspiration pneumonia and admitted to Sanuki Municipal Hospital
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Diagnostic yield and safety of repeat bronchoscopy in pulmonary disease: A five-year retrospective analysis Resp. Med. (IF 3.5) Pub Date : 2024-07-31 Fatih Uzer, Bedia Karacadir, Sevcan Yirci, Aykut Cilli, Ömer Ozbudak
In this study, we aim to analyze the frequency and indications of repeat bronchoscopic procedures performed at our hospital over a five-year period. This retrospective study was conducted at the Department of Pulmonary Diseases, Akdeniz University, and included patients who underwent bronchoscopy between January 1, 2018, and May 31, 2024. Patients who required a repeat bronchoscopy were identified
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Lower physical activity levels in youth with Cystic Fibrosis compared to healthy controls: A multicentre comparative study Resp. Med. (IF 3.5) Pub Date : 2024-07-31 Manon Kinaupenne, Stephanie Van Biervliet, Kim Van Hoorenbeeck, Heidi Schaballie, Kristof Vandekerckhove, Heleen Demeyer, Marieke De Craemer
Regular physical activity (PA) offers significant health benefits on both short (i.e., emotional well-being) and long term (i.e., fewer hospitalizations) in Youth with Cystic Fibrosis (YwCF). Regardless, evidence on PA levels in YwCF compared to healthy controls (HC) is inconsistent. Additionally, PA is a multidimensional outcome influenced by several factors such as Quadriceps strength and functional
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Treatment intensity level as a proxy for severity of chronic obstructive pulmonary disease: A risk stratification tool Resp. Med. (IF 3.5) Pub Date : 2024-07-31 Marie Dam Lauridsen, Simon Grøntved, Emil Fosbøl, Søren P. Johnsen, Jennifer K. Quint, Ulla Møller Weinreich, Jan Brink Valentin
Increasing severity of chronic obstructive pulmonary disease (COPD) is associated with increasing risk of poor outcomes. Using health registry data, we aimed to assess the association between treatment intensity levels (TIL), as a proxy for underlying COPD severity, and long-term outcomes. Using Danish nationwide registries, we identified patients diagnosed with COPD during 2001–2016, who were alive
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The risk factors for chronic cough in children: A meta-analysis covering five continents Resp. Med. (IF 3.5) Pub Date : 2024-07-31 KaiWen Zheng, LinYan Tang, Xiang Wang, Ling Chen, YuLing Zhao, Xing Chen
This study aimed to explore the risk factors for chronic cough in children and provide a reference for prevention and healthcare measures. PubMed, Web of Science, Cochrane, and EMBASE were searched for observational studies published up to April 2024. Outcome included risk factors associated with chronic cough in children. Two investigators independently searched and screened the literature, evaluated
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Respiratory physiological mechanism of two types of equal-intensity inspiratory muscle training in stable patients with chronic obstructive pulmonary disease Resp. Med. (IF 3.5) Pub Date : 2024-07-31 Weiliang Wu, Lili Guan, Bingpeng Guo, Yuqiong Yang, Rongchang Chen
This study aimed to investigate the respiratory physiological changes resulting from short-term inspiratory resistance training (R-IMT) and inspiratory threshold training (T-IMT) in patients with chronic obstructive pulmonary disease (COPD) and to compare the mechanisms of the two training methods. A total of 75 stable patients with COPD combined with inspiratory muscle weakness were randomly allocated
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Association of naples prognostic score and lung health: A population-based study Resp. Med. (IF 3.5) Pub Date : 2024-07-30 Wen Wen Wu
The Naples Prognostic Score (NPS) is a novel indicator of inflammatory and nutritional status, but its relationship to lung health is unknown. To evaluate the relationship of NPS to lung health problems. A total of 15,600 participants aged 20 years or older with an available assessment of chronic lung diseases were enrolled from the National Health and Nutrition Examination Survey 2007–2012. The NPS
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Real-world data on polysomnography- and patient-reported outcomes in hypoglossal nerve stimulation and auto-titrating positive airway pressure therapy for obstructive sleep apnea Resp. Med. (IF 3.5) Pub Date : 2024-07-30 Johannes Pordzik, Katharina Ludwig, Christopher Seifen, Christian Ruckes, Tilman Huppertz, Katharina Bahr-Hamm, Berit Hackenberg, Christoph Matthias, Haralampos Gouveris
Few data are available comparing first-line positive airway pressure (PAP) therapy of obstructive sleep apnea (OSA), especially auto-adjusting PAP (aPAP), with second-line hypoglossal nerve stimulation (HGNS) therapy. The aim of this study was to directly compare these therapeutic options by standard polysomnography (PSG)-related parameters and patient-reported outcomes in comparable groups. 20 patients
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The 1-min sit-to-stand test as a screening tool to assess exercise-induced oxygen desaturation in normoxemic people with interstitial lung disease Resp. Med. (IF 3.5) Pub Date : 2024-07-27 Simone Visser, Chloe Lawler, Caitlin C. Fermoyle, Lissa M. Spencer, Amanda J. McAnulty, Jennifer A. Alison, Susanne Webster, Lauren Troy, Helen Jo, Andrew Hayen, Tamera J. Corte
In patients with interstitial lung disease (ILD), exercise-induced desaturation during the 6-min walk test (6MWT), specifically nadir oxygen saturation (nSpO2) of ≤88 % is a negative prognostic marker. As the 6MWT is often impractical for ILD patients, the aim of this study is to compare the 1-min sit-to-stand test (1minSTS) with the 6MWT to detect exercise-induced desaturation. Participants were recruited
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Evaluating the impact of short-term nitrate-rich dietary supplementation on endothelial function in COPD: A randomized crossover study Resp. Med. (IF 3.5) Pub Date : 2024-07-24 Fernanda Beatriz Costa Delacoste, Cassia da Luz Goulart, Augusto Baumhardt Guidoti, Patrick Türck, Bruna Eibel, Maria Claudia Irigoyen, Cintia Laura Pereira de Araujo, Pedro Dal Lago
This study aimed to investigate the acute effects of dietary nitrate ingestion through -arginine supplementation or dehydrated beet consumption on endothelial function in chronic obstructive pulmonary disease (COPD) patients. The secondary outcome was to analyze arterial stiffness, plasma nitrate, and nitrate/protein concentration. In this randomized crossover study, subjects with COPD underwent three
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Five sessions of hyperbaric oxygen for critically ill patients with COVID-19-induced ARDS: A randomised, open label, phase II trial Resp. Med. (IF 3.5) Pub Date : 2024-07-24 Anders Kjellberg, Johan Douglas, Michael T. Pawlik, Adrian Hassler, Sarah Al-Ezerjawi, Emil Boström, Lina Abdel-Halim, Lovisa Liwenborg, Anna-Dora Jonasdottir-Njåstad, Jan Kowalski, Sergiu-Bogdan Catrina, Kenny A. Rodriguez-Wallberg, Peter Lindholm
Few treatment options exist for patients with COVID–19–induced acute respiratory distress syndrome (ARDS). Data on the benefits and harms of hyperbaric oxygen treatment (HBOT) for this condition is limited. To evaluate benefits and harms of HBOT in patients with COVID-19 induced ARDS. In this open-label trial conducted at three hospitals in Sweden and Germany, patients with moderate to severe ARDS
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Prescriptions of respiratory medications in children aged 0–10 years: A longitudinal drug utilization study in the POMME database Resp. Med. (IF 3.5) Pub Date : 2024-07-24 Justine Benevent, Inès Bensadallah, Anthony Caillet, Marine Michelet, Anna-Belle Beau, Isabelle Lacroix, Christine Damase-Michel
Respiratory tract disorders are common in children. However, there is no available data on the prescription of respiratory medications for children in France. This study aimed to provide an overview of medications for obstructive airway diseases prescriptions for children during the initial ten years of their lives within POMME, a French population-based cohort of children. This longitudinal, population-based
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Major adverse cardiovascular outcomes within distinct pulmonary hypertension patterns in advanced chronic kidney disease: A retrospective cohort analysis Resp. Med. (IF 3.5) Pub Date : 2024-07-23 Andrew Geller, Jose Manuel Martinez Manzano, Simone A. Jarrett, Phuuwadith Wattanachayakul, John Malin, Raul Leguizamon, Tara A. John, Rasha Khan, Ian McLaren, Alex Prendergast, Kevin Bryan Lo, Christian Witzke, Glenn Eiger
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A systematic review of the psychometric properties of the Leicester Cough Questionnaires based on the COSMIN guidelines Resp. Med. (IF 3.5) Pub Date : 2024-07-17 Anne Bottine, Julien Grandjean, Marie Standaert, Aldjia Abdellaoui, Gregory Reychler
Chronic cough affects around 10 % of the general adult population, impairing all aspects of quality of life. What are the Leicester Cough Questionnaire's psychometric properties? Electronic searches of PubMed, CINAHL, and ScienceDirect databases were conducted from inception until October 1rst 2022. All full-text articles, published in French or English, aimed at evaluating the LCQ's content validity
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Subglottic dilatation in extremely preterm infants on prolonged mechanical ventilation Resp. Med. (IF 3.5) Pub Date : 2024-07-16 Hussnain Mirza, Carlos Carmona, Callie Alt, Anniesha Noel, Alishah Batool, Gregory Logsdon, William Oh
Airway injuries are reported among preterm infants with bronchopulmonary dysplasia. We hypothesized that prolonged ventilation in preterm infants is associated with subglottic dilatation that can be reliably evaluated by point of care ultrasonography (POCUS). All preterm infants (<29-weeks) admitted to the neonatal ICU at the Advent-Health from January-2020 to June-2022 were eligible if they required
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The effect of pulmonary rehabilitation on cardiovascular risk, oxidative stress and systemic inflammation in patients with COPD Resp. Med. (IF 3.5) Pub Date : 2024-07-14 Ana Muñoz Montiel, Pedro Ruiz-Esteban, Adolfo Doménech Del Río, Pedro Valdivielso, Miguel Ángel Sánchez Chaparro, Casilda Olveira
Chronic obstructive pulmonary disease (COPD) is a leading cause of death, and cardiovascular (CV) comorbidities play a role. Evidence of the pulmonary rehabilitation (PR) effect in reducing the CV risk (CVR) in COPD patients is limited. In this study, we aimed to determine the impact of an 8-week PR program (PRP) on the CVR of the overall population and to compare the impact on the exacerbator versus
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Dupilumab responder types and predicting factors in patients with type 2 severe asthma: A real-world cohort study Resp. Med. (IF 3.5) Pub Date : 2024-07-09 L. Bult, J.C. Thelen, S.P. Rauh, J.C.C.M. in ‘t Veen, G.J. Braunstahl
Severe asthma (SA) presents a considerable healthcare challenge despite optimal standard treatment. Dupilumab, which is effective in type 2 (T2) SA patients, demonstrates variable responses, categorizing patients as non-responders, partial responders, or those achieving clinical remission. However, real-world response rates remain underexplored. Additionally, understanding the characteristics of patients
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Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A case-control study Resp. Med. (IF 3.5) Pub Date : 2024-07-09 Yeonkyung Park, Hyung-Jun Kim, Yeon Wook Kim, Byoung Soo Kwon, Yeon Joo Lee, Young-Jae Cho, Jae Ho Lee, Junghoon Kim, Jihang Kim, Kyung Hee Lee, Jong Sun Park
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology. The aim of this study was to evaluate the environmental and occupational risk factors of IPF. This hospital-based, case-control study included 206 patients with IPF selected from the Seoul National University Bundang Hospital Interstitial Lung Disease registry and 167 controls without lung disease. Data
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Practical management of oral treprostinil in patients with pulmonary arterial hypertension: Lessons from ADAPT, EXPEDITE, and expert consensus Resp. Med. (IF 3.5) Pub Date : 2024-07-08 Jacqueline Brewer, Melisa Wilson, James C. Coons, Ann Schmit, Mary E. Whittenhall, Amy Kimber, Meredith Broderick, Dasom Lee, Natalie Patzlaff, Chad Miller, Ali Ataya, Valerie LaRoy, Christopher S. King, Ashwin K. Ravichandran, John F. Kingrey, Sandeep Sahay
Oral treprostinil is a prostacyclin analogue approved to treat pulmonary arterial hypertension (PAH) by delaying disease progression and improving exercise capacity. Higher doses of oral treprostinil correlate with increased treatment benefit. Titrations may be challenging due to common side effects of prostacyclin-class therapies. The multicenter, prospective, real-world, observational ADAPT Registry
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Custom silicone Y-stents for the management of anastomotic stenosis in lung transplant recipients Resp. Med. (IF 3.5) Pub Date : 2024-07-08 Naina Sawal, Kelly M. Pennington, Robert Petrossian, Janani Reisenauer, John Mullon, David Midthun, Darlene Nelson, Dagny Anderson, Eric Edell, Sahar A. Saddoughi, Philip J. Spencer, Mauricio A. Villavicencio, Cassie C. Kennedy, John P. Scott, Steve G. Peters, Mark E. Wylam, Ryan M. Kern
Airway stenting may be needed to manage anastomotic complications in lung transplant recipients. Conventional stenting strategies may be inadequate due to anatomic variations between the recipient and donor or involvement of both the anastomosis and lobar bronchi. We investigated the efficacy of 3D-designed patient-specific silicone Y-stents in managing this scenario. 9 patients with complex airway
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Association of bronchial disease on CT imaging and clinical definitions of chronic bronchitis in a single-center COPD phenotyping study Resp. Med. (IF 3.5) Pub Date : 2024-07-08 Marisa Fat, Tyler Andersen, Jane C. Fazio, Seon Cheol Park, Fereidoun Abtin, Russell G. Buhr, Jonathan E. Phillips, John Belperio, Donald P. Tashkin, Christopher B. Cooper, Igor Barjaktarevic
Chronic Bronchitis (CB) represents a phenotype of chronic obstructive pulmonary disease (COPD). While several definitions have been used for diagnosis, the relationship between clinical definitions and radiologic assessment of bronchial disease (BD) has not been well studied. The aim of this study was to evaluate the relationship between three clinical definitions of CB and radiographic findings of
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Long-term myocardial effects of noninvasive ventilation in patients with obesity hypoventilation syndrome Resp. Med. (IF 3.5) Pub Date : 2024-07-06 I. Paranicova, S. Bodnarova, I. Trojova, Z. Hertelyova, Z. Gulasova, I. Cimbolakova, S. Genzor, P. Joppa, R. Tkacova, P. Pobeha
Chronic effects of noninvasive ventilation on myocardial function in patients with obesity hypoventilation syndrome (OHS) are scarcely understood. The aim of the present study was to evaluate the long-term effects of volume-targeted bilevel positive airway pressure ventilation (BiPAP) on cardiac parameters and myocardial biomarkers in patients with OHS. Clinically stable patients with OHS referred
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The effects of aerobic exercise training on inflammatory markers in adult tobacco smokers: A systematic review and meta-analysis of randomized controlled trials Resp. Med. (IF 3.5) Pub Date : 2024-07-05 Morteza Ghojazadeh, Hadi Pourmanaf, Vahid Fekri, Saeid Nikoukheslat, Yasmin Nasoudi, Dean E. Mills
Aerobic exercise training may reduce systemic inflammation, but the effects of this on systemic inflammatory markers in adult tobacco smokers has not been systematically reviewed. Therefore, we evaluated the effects of aerobic exercise training on C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) in adult tobacco smokers using a systematic review and meta-analysis of randomized controlled
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Prognostic impact of cytokines and chemokines in bronchoalveolar lavage fluid on acute exacerbation of fibrosing interstitial lung disease Resp. Med. (IF 3.5) Pub Date : 2024-07-05 Katsuyuki Furuta, Daichi Fujimoto, Atsushi Matsunashi, Ryota Shibaki, Shinnosuke Taniya, Masanori Tanaka, Yuri Shimada, Kazuma Nagata, Keisuke Tomii, Nobuyuki Yamamoto
Acute exacerbation of fibrosing interstitial lung disease (AE-FILD) is a serious condition with a high mortality rate. We aimed to comprehensively analyze cytokines in bronchoalveolar lavage fluid and their association with the clinical course of AE-FILD. We retrospectively enrolled 60 patients with AE-FILD who underwent bronchoalveolar lavage. We comprehensively measured 44 cytokines and chemokines
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Influence of heart failure (HF) comorbidity in chronic obstructive pulmonary disease (COPD) and isolated forms of HF and COPD on cardiovascular function during hospitalization Resp. Med. (IF 3.5) Pub Date : 2024-07-04 Nathany Souza Schafauser, Luciana Maria Malosá Sampaio, Alessandro Domingues Heubel, Erika Zavaglia Kabbach, Débora Mayumi de Oliveira Kawakami, Naiara Tais Leonardi, Viviane Castello-Simões, Audrey Borghi-Silva, Renata Gonçalves Mendes
Coexistence of chronic obstructive pulmonary disease(COPD) and heart failure(HF) is associated with systemic inflammation, myocardial injury, and arterial stiffening, impacting cardiovascular risk and prognosis in patients. Arterial stiffness, reduced nitric oxide synthesis, and altered cardiac autonomic control further link COPD and HF pathophysiology, emphasizing the need for comprehensive cardiovascular
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Patterns of physical activity of people with COPD during participation in a pulmonary rehabilitation program Resp. Med. (IF 3.5) Pub Date : 2024-07-04 Joshua A. Bishop, Lissa M. Spencer, Tiffany J. Dwyer, Zoe J. McKeough, Amanda McAnulty, Sonia Cheng, Jennifer A. Alison
Very few studies have examined patterns of physical activity (PA) during a pulmonary rehabilitation (PR) program in people with COPD. To compare the patterns of PA in: 1) the week before commencing PR (pre-PR) with a week during PR (PR week); 2) PR days and non-PR days during a PR week; 3) pre-PR and the week following PR completion (post-PR). This was a multicenter, prospective cohort study. Participants
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Factors related to the implementation of pulmonary rehabilitation in Jordan: Perspective of healthcare professionals Resp. Med. (IF 3.5) Pub Date : 2024-07-04 Adnan Wshah, Nisrin Alqatarneh, Saad Al-Nassan, Roger Goldstein
Although the benefits of pulmonary rehabilitation (PR) in the management of chronic respiratory disease conditions (CRC) are well-documented, it remains underutilized. In Jordan, the scarcity of PR services denies those with CRC the opportunity to improve their functional capacity, mental health, and quality of life. To explore the factors related to the implementation of PR in Jordan from the perspective