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Elevated liver enzymes and fasting glucose levels correlate with neuropathy in patients diagnosed with alcohol use disorder independently of the blood thiamine levels Alcohol Alcohol. (IF 2.8) Pub Date : 2024-03-12 Michail Papantoniou, Thomas Zampelis, Panagiotis Kokotis, Elias Tzavellas, Thomas Paparrigopoulos, Stylianos Chatzipanagiotou, Chrysoula Nikolaou, Michail Rentzos
Aims Chronic alcohol consumption is well known to cause peripheral neuropathy, affecting both small and large nerve fibers. The aim of this study was to correlate biochemical and neurophysiological findings and investigate possible biomarkers and risk factors for pathogenetic mechanisms of neuropathy in patients diagnosed with alcohol use disorder (AUD). Methods Ninety patients diagnosed with AUD were
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Alcohol-related cognitive impairments in patients with and without cirrhosis Alcohol Alcohol. (IF 2.8) Pub Date : 2024-02-17 Bernard Angerville, Marie-Alix Jurdana, Margaret P Martinetti, Ruxandra Sarba, Éric Nguyen-Khac, Mickael Naassila, Alain Dervaux
Aims up to 80% of patients with alcohol use disorder display cognitive impairments. Some studies have suggested that alcohol-related cognitive impairments could be worsened by hepatic damage. The primary objective of this study was to compare mean scores on the Brief Evaluation of Alcohol-Related Neurocognitive Impairments measure between alcohol use disorder patients with (CIR+) or without cirrhosis
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A social media intervention for high-intensity drinking among emerging adults: a pilot randomized controlled trial Alcohol Alcohol. (IF 2.8) Pub Date : 2024-02-16 Erin E Bonar, Chiu Y Tan, Anne C Fernandez, Jason E Goldstick, Lyndsay Chapman, Autumn R Florimbio, Maureen A Walton
Aims High-intensity drinking (HID) is a pattern of risky drinking defined as at least 8 drinks (for women) or 10 drinks (for men) in a single episode. Individuals engaged in HID may be at greater risk for consequences, necessitating tailored interventions. Herein, we report the feasibility and acceptability of a social media-delivered 8-week intervention for emerging adults with recent HID. Methods
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Patterns of publicly funded naltrexone use among patients diagnosed with alcohol use disorder in Ontario Alcohol Alcohol. (IF 2.8) Pub Date : 2024-02-01 Nima Tourchian, Daniel McCormack, Pamela Leece, Mina Tadrous, Tara Gomes
Aims Naltrexone is recommended first-line to manage alcohol use disorder (AUD). With previous studies indicating poor retention on naltrexone, we determined duration of naltrexone use and assessed the association between prescription setting and time to discontinuation in Ontario. Methods We conducted a retrospective population-based cohort study among Ontario public drug beneficiaries diagnosed with
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The criminal justice system in alcohol use treatment: a nationwide analysis of racial disparities in treatment referral and completion Alcohol Alcohol. (IF 2.8) Pub Date : 2024-01-24 Madeline R Stenersen, MacKenzie Peltier, Sherry A McKee
Background Alcohol use and the criminal justice (CJ) system have long been integrally connected in the United States and have both disproportionally impacted Communities of Color. Despite this connection, scholarly literature has largely focused on substance use as a whole, and little literature has examined the influence of race on CJ referral to alcohol treatment and treatment outcomes. Methods A
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Baclofen in the treatment of alcohol use disorder: tailored doses matter Alcohol Alcohol. (IF 2.8) Pub Date : 2024-01-24 Renaud de Beaurepaire, Philippe Jaury
Aims To address the question of tailored baclofen prescribing in alcohol use disorder (AUD) in relation to dose-dependent efficacy and the potential danger of high doses and to provide suggestions for the use of high doses of baclofen in the treatment of AUD. The context is the approvement in France of baclofen in the treatment of AUD without dose limitation, making French physicians, who usually prescribe
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A high-resolution PheWAS approach to alcohol-related polygenic risk scores reveals mechanistic influences of alcohol reinforcing value and drinking motives Alcohol Alcohol. (IF 2.8) Pub Date : 2024-01-23 Wei Q Deng, Kyla Belisario, Joshua C Gray, Emily E Levitt, James MacKillop
Aims This study uses a high-resolution phenome-wide approach to evaluate the motivational mechanisms of polygenic risk scores (PRSs) that have been robustly associated with coarse alcohol phenotypes in large-scale studies. Methods In a community-based sample of 1534 Europeans, we examined genome-wide PRSs for the Alcohol Use Disorders Identification Test (AUDIT), drinks per week, alcohol use disorder
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Development of the lyrics-based deep learning algorithm for identifying alcohol-related words (LYDIA) Alcohol Alcohol. (IF 2.8) Pub Date : 2024-01-18 Abraham Albert Bonela, Zhen He, Dan-Anderson Luxford, Benjamin Riordan, Emmanuel Kuntsche
Background Music is an integral part of our lives and is often played in public places like restaurants. People exposed to music that contained alcohol-related lyrics in a bar scenario consumed significantly more alcohol than those exposed to music with less alcohol-related lyrics. Existing methods to quantify alcohol exposure in song lyrics have used manual annotation that is burdensome and time intensive
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Meeting-makers make meaning: alcoholics anonymous participation and personal meaningfulness Alcohol Alcohol. (IF 2.8) Pub Date : 2024-01-18 Benjamin L Thompson, Nasim Maleki, John F Kelly, Marlene Oscar-Berman
Aims The central aim of this study was to determine whether intentional, voluntary alcoholics anonymous (AA) participation showed any independent association with affect, over and above that which has been observed in association with other recovery-related behaviors, such as abstinence, among individuals with a history of alcohol use disorder. Additionally, we sought to determine the nature of the
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Non-beverage alcohol consumption in Russia: new evidence from Jewish Autonomous Oblast Alcohol Alcohol. (IF 2.8) Pub Date : 2024-01-11 Andrey Korotayev, Vadim Ustyuzhanin, Yevgeniy Ivanov, Leonid Issaev
Introduction Previous studies in Izhevsk, Novosibirsk, and Kazan have found that non-beverage alcohol is a large part of alcohol consumption in Russia. Whereas those places are relatively high-income cities, there are no studies about such a problem in low-income regions of Russia. The aim of this study is to investigate correlates and factors associated with non-beverage alcohol consumption in eastern
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Role of glycogen synthase kinase-3β in dependence and abuse liability of alcohol Alcohol Alcohol. (IF 2.8) Pub Date : 2023-12-26 Masahiro Oka, Rui Yoshino, Nobue Kitanaka, F Scott Hall, George R Uhl, Junichi Kitanaka
Background Alcohol is a major abused drug worldwide that contributes substantially to health and social problems. These problems result from acute alcohol overuse as well as chronic use, leading to alcohol use disorder (AUD). A major goal of this field is to establish a treatment for alcohol abuse and dependence in patients with AUD. The central molecular mechanisms of acute alcohol actions have been
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Disruption of circadian rhythms promotes alcohol use: a systematic review Alcohol Alcohol. (IF 2.8) Pub Date : 2023-12-21 Morgan J Nelson, Paul S Soliman, Ryan Rhew, Rachel N Cassidy, Carolina L Haass-Koffler
This systematic review investigates the bidirectional relationship between alcohol consumption and disrupted circadian rhythms. The goal of this study was to identify (i) the types of circadian rhythm disruptors (i.e. social jet lag, extreme chronotypes, and night shift work) associated with altered alcohol use and (ii) whether sex differences in the consequences of circadian disruption exist. We conducted
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'Reputation, reputation, reputation! Oh, I have lost my reputation!'; A literature review on alcohol addiction in the British Sikh and/or Punjabi community and the barriers to accessing support. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-28 Karamdeep Kaur
AIMS The literature review aimed to identify the barriers the Punjabi and/or Sikh community have in accessing support for alcohol addiction. METHOD A systematic review of the literature was undertaken of four scholarly databases, Google Scholar and grey literature on UK-based research conducted after 1980 into alcohol addiction in the Punjabi and/or Sikh community. Fourteen papers met the inclusion
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Association of over the counter "hangover remedy" use with alcohol use problems and consumption patterns among young adults. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-28 Dae-Hee Han,Jordan P Davis,Daryl L Davies,John D Clapp,Eric R Pedersen,Adam M Leventhal
This cross-sectional study of young adults examined associations of hangover remedy use with alcohol use problems. Results suggest that ever-use of hangover remedy products was positively associated with alcohol use problem score, drinks per typical drinking day, and alcohol use disorder symptom count. Use of hangover remedies among young adults merits further scientific and regulatory attention.
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Reduction of alcohol use and increase in psychological flexibility after a naturalistic psychedelic experience: a retrospective survey Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-20 Ewen Kervadec, Baptiste Fauvel, Lana Strika-Bruneau, Ammar Amirouche, Vincent Verroust, Pascale Piolino, Bruno Romeo, Amine Benyamina
Introduction Alcohol use can be significantly associated with negative social, professional, and health outcomes. Even more so, alcohol use disorder (AUD) is a critical public health issue and major avoidable risk factor. This study aimed to examine the effect of a naturalistic psychedelic experience on alcohol use and related measures. Methods A retrospective online survey was conducted on 160 individuals
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Effect of a moderate alcohol dose on physiological responses during rest and prolonged cycling Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-20 Andrew Marley, Marianna Bakali, Charlie Simpson
Aim: We examined the acute effects of a moderate alcohol dose (48 g) ingested before prolonged cycling on acute physiological responses in eight healthy males (mean ± SD; 23 ± 2 years; 1.77 ± 0.04 m; 75.8 ± 4.1 kg). Methods: In a randomized order, euhydrated participants completed two experimental sessions with the sequence of 150-min seated at rest, 90-min of cycling at 50% of the maximal rate of
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A machine learning model for the prediction of unhealthy alcohol use among women of childbearing age in Alabama. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-15 Karen A Johnson,Justin T McDaniel,Joana Okine,Heather K Graham,Ellen T Robertson,Shanna McIntosh,Juliane Wallace,David L Albright
INTRODUCTION This study utilizes a machine learning model to predict unhealthy alcohol use treatment levels among women of childbearing age. METHODS In this cross-sectional study, women of childbearing age (n = 2397) were screened for alcohol use over a 2-year period as part of the AL-SBIRT (screening, brief intervention, and referral to treatment in Alabama) program in three healthcare settings across
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A retrospective cohort analysis of treatment outcomes of patients with tuberculosis who used substances in Tel Aviv, Israel Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-14 Ehud Kaliner, Sandy Bornstein, Doaa Kabha, Moshe Lidji, Rivka Sheffer, Zohar Mor
Aims To outline the demographic, clinical, laboratory characteristics, and treatment outcomes of tuberculosis (TB) patients who used substances. Methods This retrospective cohort study compared 50 TB patients who used substances with a matched random sample of 100 TB patients who did not use substances between 2007 and 2017. Treatment failure was defined as a sputum smear or culture that tested positive
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The prevalence of occupational burnout and its individual and situational predictors among addiction therapists Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-14 Justyna Klingemann, Łukasz Mokros, Halina Sienkiewicz-Jarosz, Piotr Świtaj
This study assesses the prevalence and individual and organizational predictors of occupational burnout among addiction therapists. A total of 452 addiction therapists from a representative sample of 184 Polish alcohol treatment facilities (outpatient and inpatient) participated in the study (facility response rate = 42%). The Oldenburg Burnout Inventory was used to measure occupational burnout, and
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Unrecorded alcohol consumption in Lithuania: a modelling study for 2000-2021. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-11 Mindaugas Štelemėkas,Nijolė Goštautaitė Midttun,Shannon Lange,Vaida Liutkutė-Gumarov,Jakob Manthey,Laura Miščikienė,Janina Petkevičienė,Ričardas Radišauskas,Jürgen Rehm,Justina Trišauskė,Tadas Telksnys,Mark James Thompson
The aim of the study was to estimate unrecorded alcohol consumption in Lithuania for the period 2000-2021 using an indirect method for modelling consumption based on official consumption data and indicators of alcohol-related harm. Methodology employed for estimating the unrecorded alcohol consumption was proposed by Norström and was based on the country's 2019 European Health Interview Survey and
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Alcohol and cancer: a denied association the statement of the Italian society on alcohol (Società Italiana di Alcologia-SIA). Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-11 Gianni Testino,Emanuele Scafato,Valentino Patussi,Patrizia Balbinot,Andrea Ghiselli,Fabio Caputo
Alcohol consumption (AC) is carcinogenic to humans. The Italian Society on Alcohol (Società Italiana di Alcologia) defines excessive AC as anything greater than zero. It is not appropriate to associate AC with cardiovascular disease prevention. This is for prudence and to protect public health. It also asks to include information on alcohol labels that AC is associated with cancer.
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Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-11 Stephanie E Wemm,Max Golden,Jorge Martins,Nia Fogelman,Rajita Sinha
Chronic heavy alcohol use profoundly affects the cardiovascular system, contributing to several life-threatening cardiovascular diseases. Heart rate variability (HRV), or the fluctuations in heart rate, reflects dynamic autonomic nervous system processes that change to meet biological demands and environmental challenges. In the current study, we examined whether HRV metrics are altered in alcohol
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Alcohol metabolism in alcohol use disorder: a potential therapeutic target Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-11 Taylor Lehner, Bin Gao, Bryan Mackowiak
Ethanol metabolism plays an essential role in how the body perceives and experiences alcohol consumption, and evidence suggests that modulation of ethanol metabolism can alter the risk for alcohol use disorder (AUD). In this review, we explore how ethanol metabolism, mainly via alcohol dehydrogenase and aldehyde dehydrogenase 2 (ALDH2), contributes to drinking behaviors by integrating preclinical and
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Promoting Alcohol Reduction in Non-Treatment Seeking parents (PAReNTS): a pilot feasibility cluster randomized controlled trial of brief alcohol interventions with parents in contact with child safeguarding services Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-11 Ruth McGovern, Deborah Smart, Hayley Alderson, Tony Fouweather, Eileen Kaner
Many parents who come into contact with early help and children’s social care services are risky drinkers. This study aimed to investigate the feasibility and acceptability of conducting a trial of brief alcohol interventions within this setting. We conducted a three-arm pilot feasibility cluster randomised controlled trial in the North-East of England. The additive interventions were: i) screening
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Involuntary social isolation and alcohol consumption: an ecological momentary assessment in Germany amid the COVID-19 pandemic Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-07 Matthias Haucke, Stephan Heinzel, Shuyan Liu
Aims Alcohol consumption often occurs in a social setting, which was affected by social distancing measures amid the coronavirus disease-2019 (COVID-19) pandemic. In this study, we examine how involuntary social isolation (i.e. comparing a no-lockdown stage with a lockdown stage) affects the association between loneliness, social activities, and drinking behavior. Method We performed an ecological
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Satisfaction with a digital support tool targeting alcohol consumption: perspectives from participants in a randomized control trial Alcohol Alcohol. (IF 2.8) Pub Date : 2023-11-06 Elizabeth S Collier, Jenny Blomqvist, Marcus Bendtsen
Aim Intervention design may be improved through evaluating the feedback from those who have been exposed to such interventions. As such, here the perspectives of the intervention group from a recent randomized control trial investigating the effectiveness of a digital alcohol intervention, in terms of perceived suitability and usefulness of the support tool they engaged with, were investigated. Methods
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Accuracy of transdermal alcohol monitoring devices in a laboratory setting Alcohol Alcohol. (IF 2.8) Pub Date : 2023-10-24 Eileen Brobbin, Paolo Deluca, Simon Coulton, Colin Drummond
The development of transdermal alcohol sensors (TASs) presents a new method to monitor alcohol consumption with the ability to objectively measure data 24/7. We aimed to evaluate the accuracy of two TASs (BACtrack Skyn and Smart Start BARE) in a laboratory setting. Thirty-two adults received a dose of ethanol 0.56 g/kg body weight as a 20% solution while wearing the two TASs and provided Breath Alcohol
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Between-hospital care referrals for severe alcohol-related liver disease during the COVID-19 pandemic, 2020 to 2022. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-10-23 Erik Almazan,Juliette Dixon,Avi Gerstenblith,Sarah Andrews,James Flanary,Andrew M Cameron,Ahmet Gurakar,Po-Hung Chen
Increased alcohol consumption during the coronavirus disease 2019 pandemic is projected to impact alcohol-related liver disease (ALD) morbidity and mortality. Inter-hospital escalation-of-care referral requests to our tertiary-care hepatology unit were analyzed from January 2020 through December 2022. Most requests to our center were for ALD with an increase in requests from intermediate care units
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Discrimination, gender dysphoria, drinking to cope, and alcohol harms in the UK trans and non-binary community Alcohol Alcohol. (IF 2.8) Pub Date : 2023-10-18 Emma L Davies, Ivan Ezquerra-Romano, Beth Thayne, Zhi Holloway, Jacob Bayliss, Stewart O’Callaghan, Dean J Connolly
Transgender (trans) and non-binary people may be at increased risk of alcohol harms, but little is known about motives for drinking in this community. This study explored the relationship between risk of alcohol dependence, experience of alcohol harms, drinking motives, dysphoria, and discrimination within a United Kingdom sample of trans and non-binary people with a lifetime history of alcohol use
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Screening for alcohol use in primary care: assessing French general practitioner practices Alcohol Alcohol. (IF 2.8) Pub Date : 2023-10-11 Tangui Barré, Vincent Di Beo, Perrine Roux, Abbas Mourad, Pierre Verger, Lisa Fressard, Thomas Herault, Jean-François Buyck, François Beck, Patrizia Carrieri
Alcohol use is a leading risk factor for premature death and disability. To tackle this issue, more systematic and accurate screening for at-risk consumption is needed in healthcare systems, especially by general practitioners (GPs). We assessed the frequency of at-risk consumption screening by GPs in France. We also identified characteristics associated with more frequent screening and greater use
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Early onset adolescent binge drinking is associated with reduced white matter integrity in post-9/11 adult veterans Alcohol Alcohol. (IF 2.8) Pub Date : 2023-10-04 Aubrey A Knoff, Arielle R Knight, David H Salat, Amrita Bedi, Alyssa Currao, Jennifer R Fonda, Regina E McGlinchey, Catherine B Fortier
Adolescence represents a critical period of neural development during which binge drinking (BD) is prevalent. Though prior work has shown that white matter (WM) integrity is susceptible to damage from excessive alcohol intake in adults, the effect of early adolescent BD on WM health in adulthood remains unknown. Veterans with a history of BD onset before age 15 [n = 49; mean age = 31.8 years; early-onset
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Response to Letter to the Editors regarding ‘A Meta-Regression of Trial Features Predicting the Effects of Alcohol Use Disorder Pharmacotherapies on Drinking Outcomes in Randomized Clinical Trials: A Secondary Data Analysis’ Alcohol Alcohol. (IF 2.8) Pub Date : 2023-10-03 Erica N Grodin, Suzanna Donato, Han Du, ReJoyce Green, Spencer Bujarski, Lara A Ray
Short Summary: The Letter to the Editors regarding our article was reviewed. The take-home message is that substantively, the authors of the letter are referencing a paper that asks a different research question in a different set of studies. When we ask different questions, we are not surprised when we reach different answers.
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Alcohol outlet density and marketing in Abeokuta, Nigeria Alcohol Alcohol. (IF 2.8) Pub Date : 2023-09-14 Ogochukwu W Odeigah, Robert Patton, Pamela Trangenstein
Aim: The physical availability of alcohol is a modifiable determinant of alcohol consumption and related harm. However, Nigeria currently does not have national regulations restricting the physical availability of alcohol. The study measured alcohol outlet density and marketing in Abeokuta, Nigeria. Methods: A descriptive community design was employed. Seven wards in Abeokuta South local government
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Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-09-09 Jessica E S Shay,Augustin Vannier,Stephanie Tsai,Rachel Mahle,Paige McLean Diaz,Eric Przybyszewski,Prasanna K Challa,Suraj J Patel,Joji Suzuki,Esperance Schaefer,Russell P Goodman,Jay Luther
BACKGROUND Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. AIMS In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. METHODS In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both
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Efficacy of psychosocial interventions to reduce alcohol use in comorbid alcohol use disorder and alcohol-related liver disease: a systematic review of randomized controlled trials. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-09-09 Sofia Hemrage,Eileen Brobbin,Paolo Deluca,Colin Drummond
This systematic review (PROSPERO CRD42021234598) fills a gap in the literature by assessing the efficacy of psychosocial interventions in patients with alcohol use disorder and alcohol-related liver disease (ARLD), focusing on drinking reduction and abstinence as intervention goals. A systematic search for randomized controlled trials (RCTs) was conducted across various databases. Study screening and
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The adolescent and young adult microbiome and its association with substance use: a scoping review Alcohol Alcohol. (IF 2.8) Pub Date : 2023-09-04 Brittney D Browning, Anna E Kirkland, Rejoyce Green, Melinda Engevik, Alexander V Alekseyenko, Lorenzo Leggio, Rachel L Tomko, Lindsay M Squeglia
Aims The microbiome is a critical factor in health throughout human development. The aims of this scoping review are to (i) elucidate the differences between the youth (post-natal day 21–65 for rodents, 2–7 years for non-human primates, and 10–25 years for humans) microbiome with other life stages and (ii) identify youth-specific microbial changes associated with substance use. Methods Peer-reviewed
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Characterizing Twitter chatter about temporary alcohol abstinence during “Dry January” Alcohol Alcohol. (IF 2.8) Pub Date : 2023-09-01 Alex M Russell, Ben N Montemayor, Shawn C Chiang, Plangkat J Milaham, Adam E Barry, Hsien-Chang Lin, Brandon G Bergman, Philip M Massey
With roots as a public health campaign in the United Kingdom, “Dry January” is a temporary alcohol abstinence initiative encouraging participants to abstain from alcohol use during the month of January. Dry January has become a cultural phenomenon, gaining increasing news media attention and social media engagement. Given the utility of capturing naturalistic discussions around health topics on social
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Pregnancy-specific alcohol policies and admissions to substance use disorder treatment for pregnant people in the USA Alcohol Alcohol. (IF 2.8) Pub Date : 2023-08-25 Nancy F Berglas, Meenakshi S Subbaraman, Sue Thomas, Sarah C M Roberts
Aims We examined relationships between pregnancy-specific alcohol policies and admissions to substance use disorder treatment for pregnant people in the USA. Methods We merged state-level policy and treatment admissions data for 1992–2019. We aggregated data by state-year to examine effects of nine pregnancy-specific alcohol policies on the number of admissions of pregnant women where alcohol was reported
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Relationship between drinking risk and preferences for helping resources among emerging adults living in disadvantaged communities in the Southeastern United States Alcohol Alcohol. (IF 2.8) Pub Date : 2023-08-11 Jalie A Tucker, JeeWon Cheong, Lesleigh A Stinson, Susan D Chandler
Compared to campus-based alcohol interventions for college students, services for emerging adult (EA) risky drinkers who reside off-campus in disadvantaged communities are not well established. This web survey assessed drinking practices, problems, and preferences for professional and lay helping resources spanning digital and in-person formats among community-dwelling EAs to guide services for them
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Impact of the COVID-19 pandemic on emergency department alcohol intoxication presentations and positive screens for problem drinking Alcohol Alcohol. (IF 2.8) Pub Date : 2023-08-09 R Sutariya, M Hamzeh, S Desale, M Mete, M Mazer-Amirshahi, Lewis S Nelson
Our aim was to assess the changes in patients presenting with acute alcohol intoxications or positive screens for problem drinking during the COVID-19 pandemic compared to before the pandemic in a seven-hospital health system. A retrospective chart review of emergency department (ED) visits from seven hospitals in the Washington, DC/Baltimore, and MD area from January 2019 to June 2021 is provided
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Neuroanatomical predictors of problematic alcohol consumption in adolescents: a systematic review of longitudinal studies Alcohol Alcohol. (IF 2.8) Pub Date : 2023-08-09 Faraz Honarvar, Saman Arfaie, Hanie Edalati, Arashk Ghasroddashti, Arad Solgi, Mohammad Sadegh Mashayekhi, Mohammad Mofatteh, Lily Yuxi Ren, Angela T H Kwan, Kamyar Keramatian
Aims This study aimed to systematically review the literature on neuroanatomical predictors of future problematic drinking in adolescents. Methods Using PRISMA guidelines, a systematic review was conducted to evaluate neuroanatomical predictors of problematic alcohol consumption in adolescents. EMBASE, MEDLINE, and PsycINFO databases were searched from inception to 6 January 2023. Studies were included
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Baclofen during alcohol detoxification reduces the need for additional diazepam: a randomized placebo-controlled trial Alcohol Alcohol. (IF 2.8) Pub Date : 2023-08-01 Cleo L Crunelle, Sami Jegham, Nathalie Vanderbruggen, Frieda Matthys
Baclofen may reduce the symptoms of alcohol withdrawal, as an alternative or as an adjuvant for benzodiazepines, but the available data are insufficient to support baclofen-assisted alcohol withdrawal. This study investigated the need for diazepam during acute alcohol withdrawal in patients receiving baclofen. In a single-blind, dose-dependent randomized controlled trial with three study arms, 63 patients
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Alcohol consumption and oral microbiome composition in a sample of healthy young adults Alcohol Alcohol. (IF 2.8) Pub Date : 2023-07-28 Gyles Ward, Jenna I Wurster, Philip S Lamb, Grace DeCost, Peter Belenky, Mollie A Monnig
The oral microbiomes of 24 healthy adults (50% female; mean age = 24.3) were examined using 16 s ribosomal RNA sequencing and compared between light and heavy drinkers. Beta diversity was related at the trend level to drinking group, and light drinkers had significantly higher abundances of key oral taxa such as Lactobacillales. These preliminary results may offer insight into early effects of heavy
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Psychometric properties of the German Penn Alcohol Craving Scale Alcohol Alcohol. (IF 2.8) Pub Date : 2023-07-27 Helmut Nakovics, Sabine Hoffmann, Anne Koopmann, Patrick Bach, Martin Abel, Wolfgang H Sommer, Falk Kiefer, Christian Weinland, Claudia von Zimmermann, Eva-Maria Siegmann, Johannes Kornhuber, Christiane Mühle, Udo Schneider, Sermin Toto, Thomas Hillemacher, Helge Frieling, Stefan Bleich, Christian K Eberlein, Bernd Lenz
Craving for alcohol is an important diagnostic criterion in alcohol use disorder (AUD) and an established predictor of future relapse. The 5-item Penn Alcohol Craving Scale (PACS) is one of the most widely used questionnaires to quantify craving and has been translated into different languages. It is assumed that the PACS constitutes one factor, although theoretical considerations suggest an additional
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N acetylcysteine in the treatment of alcohol use disorder: a randomized, double-blind, placebo-controlled trial Alcohol Alcohol. (IF 2.8) Pub Date : 2023-07-19 Kirsten C Morley, Siena Peruch, Claire Adams, Ellen Towers, Chris Tremonti, Joshua Watt, Nazila Jamshidi1, Paul S Haber
N-acetyl cysteine (NAC) is a potent antioxidant that modulates glutamatergic signalling which is thought to play a role in alcohol use disorder (AUD). There have been no clinical trials investigating NAC for AUD. We aimed to conduct a 28 day double-blind, placebo-controlled (PL) randomized trial of NAC in the treatment of AUD (NCT03879759). A total of 42 participants with AUD (56% alcohol-related liver
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The global burden of alcoholic liver disease: a systematic analysis of the global burden of disease study 2019 Alcohol Alcohol. (IF 2.8) Pub Date : 2023-07-15 Nan Zhang, Feng Xue, Xiao-Ning Wu, Wei Zhang, Jing-Jing Hou, Jun-Xi Xiang, Yi Lv, Xu-Feng Zhang
Alcohol use is a major risk factor for the burden of mortality and morbidity. Alcoholic cirrhosis (AC) and alcoholic liver cancer (ALC) are most important and severe liver disease outcomes caused by alcohol use. The objectives of the current study were to investigate the global prevalence and burden of disease in disability-adjusted life years (DALYs) for AC and ALC, based on data from the Global Burden
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Factors associated with discharge against medical advice in alcohol withdrawal patients. Alcohol Alcohol. (IF 2.8) Pub Date : 2023-09-09 Rachel Coleman,Simon Coulton,Thomas Phillips
This study aimed to examine characteristics associated with discharge against medical advice from the hospital in alcohol withdrawal patients, supporting the work of hospital staff and Alcohol Care Teams and identifying characteristics that may help target patients most likely to discharge against medical advice. We used Hospital Episode Statistics Data to identify demographic and clinical variables
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Brain-derived neurotrophic factor Val66Met polymorphism moderates the relationship between impulsivity, negative emotions, and binge drinking intensity in university students Alcohol Alcohol. (IF 2.8) Pub Date : 2023-06-19 Farid Benzerouk, Fabien Gierski, Séverine Lannoy, Sarah Barrière, Franca Schmid, Charles-Antoine Papillon, Hakim Houchi, Elodie DeWever, Véronique Quaglino, Mickael Naassila, Arthur Kaladjian
Studies on the genetic factors involved in binge drinking (BD) and its associated traits are very rare. The aim of this cross-sectional study was to investigate differences in the association between impulsivity, emotion regulation and BD in a sample of young adults according to the rs6265/Val66Met variant in the brain-derived neurotrophic factor (BDNF) gene, a well-known candidate gene in alcohol
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Examining the predictive potential of depressed mood and alcohol misuse on risky driving Alcohol Alcohol. (IF 2.8) Pub Date : 2023-06-15 Nevicia F Case, Thomas G Brown
Aims: Male driving while impaired (DWI) offenders are at heightened risk for engaging in risky driving. Males in a depressed mood are also more prone to alcohol misuse, which may further contribute to risky driving. This manuscript investigates the predictive potential of combined depressed mood and alcohol misuse on risky driving outcomes 3 and 9 years after baseline in male DWI offenders. Methods:
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Risky drinking and other drug use in adults with chronic conditions in the United States: differential associations by race/ethnicity Alcohol Alcohol. (IF 2.8) Pub Date : 2023-06-01 Won Kim Cook, William C Kerr, Christina C Tam, Libo Li
Co-use of multiple drugs may prolong or increase heavy drinking, even for individuals with health conditions adversely affected by it. Patterns of alcohol and drug use may vary across racial/ethnic groups, with differential implications for health. This study examines racial/ethnic differences in the associations between risky drinking and other drug use in adults with diabetes, hypertension, heart
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The association between population drinking and ischemic heart disease mortality in educational groups Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-20 Thor Norström, Jonas Landberg
A large number of observational studies have found a J-shaped relationship between alcohol intake and ischemic heart disease (IHD) risk. However, some studies suggest that the alleged cardio-protective effect may be an artifact in the way that the elevated risk for abstainers is due to self-selection on risk factors for IHD. The aim of this paper is to estimate the association between alcohol and IHD-mortality
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Impact of alcohol home delivery and other methods of obtaining alcohol in young adults Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-13 Jonathan K Noel, Samantha R Rosenthal
Aims: To estimate the use of home alcohol delivery and other methods of obtaining alcohol, rates of ID checking for home alcohol delivery purchases, and associations with alcohol-related consequences. Methods: Surveillance data from 784 lifetime drinkers participating in the 2022 Rhode Island Young Adult Survey were used. The method of obtaining alcohol (e.g. type of purchase, gifted, theft) was assessed
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Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-13 Selin Özkan-Kotiloğlu, Dilek Kaya-Akyüzlü, Rabia Yurdakul, Mukaddes Asena Yıldırım, İnci Özgür-İlhan
Aims: The dynorphin (DYN)/Kappa Opioid Receptor (KOR) system has been suggested to be involved in both negative affective states and the action of alcohol. The present study was undertaken to explore whether the DYN/KOR system genes, PDYN and OPRK1, influence on individual differences in the intensity of depressive symptoms at admission as well as the risk of alcohol use disorder (AUD) risk in a sample
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Ghrelin and impulsivity relationship in alcohol-dependent patients and healthy individuals Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-08 Ece Agtas-Ertan, Ozlem Dogan, Inci Ilhan
Aims: Abundant research indicates that ghrelin hormone levels are associated with alcohol use and addiction. One of the mediators of this association may be impulsivity, which is one of the common traits observed in alcohol addiction and some eating disorders. This study evaluated participants with alcohol dependency and healthy volunteers to determine whether trait impulsivity and ghrelin levels are
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Enhanced diagnosis and prognosis of severe alcoholic hepatitis using novel metabolomic biomarkers Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-08 Adelina Horhat, Petra Fischer, Oana Nicoara-Farcau, Ioana Rusu, Corina Morar, Andreea Bumbu, Mina Ignat, Bogdan Procopet, Carmen Socaciu, Zeno Sparchez, Horia Stefanescu
Aim: Differentiating alcoholic hepatitis (AH) from acute decompensation of alcoholic cirrhosis (DC) is challenging, as the presentation and biochemistry are similar. We aimed to identify potential metabolomic biomarkers to differentiate between AH and DC, and to predict short-term mortality. Methods: We included consecutive biopsy proven AH and DC patients, which were managed according to current guidelines
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Cannabidiol as a candidate pharmacotherapy for sleep disturbance in alcohol use disorder Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-04 Marie N S Gendy, Benicio N Frey, Michael Van Ameringen, Nirushi Kuhathasan, James MacKillop
Among individuals with alcohol use disorder (AUD), it is estimated that the majority suffer from persistent sleep disturbances for which few candidate medications are available. Our aim wass to critically review the potential for cannabidiol (CBD) as a treatment for AUD-induced sleep disturbance. As context, notable side effects and abuse liability for existing medications for AUD-induced sleep disturbance
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The nature and extent of outdoor alcohol marketing in Wellington, New Zealand: a longitudinal audit and spatio-temporal analysis of outdoor alcohol marketing Alcohol Alcohol. (IF 2.8) Pub Date : 2023-05-03 Tim Chambers, Timothy Royds, Amanda C Jones
Aim exposure to alcohol marketing is associated with increased consumption. We aimed to (i) measure the nature and extent of outdoor alcohol marketing within a high-density urban neighbourhood and (ii) examine temporal and spatial trends in alcohol marketing. Methods this study used a longitudinal design to monitor paid advertising in public spaces over two 10-week periods in Wellington, New Zealand
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Prevalence of alcohol use amongst sexual and gender minority (LGBTQ+) communities in the UK: a systematic scoping review Alcohol Alcohol. (IF 2.8) Pub Date : 2023-04-28 Catherine Meads, Laetitia Zeeman, Nigel Sherriff, Kay Aranda
Background: globally, alcohol use rates vary by sexual orientation and gender identity (SOGI), but UK government statistics on alcohol use in the LGBTQ+ population are missing. Aim: this systematic scoping review determined the prevalence of alcohol use amongst gender and sexual minority people in the UK. Methods: empirical UK studies from 2010 onwards reporting the prevalence of alcohol use in SOGI
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Formation of phosphatidylethanol and ethylglucuronide after low to moderate alcohol consumption in volunteers with a previous three-week alcohol abstinence Alcohol Alcohol. (IF 2.8) Pub Date : 2023-04-25 Josefine Herzog, Gisela Skopp, Frank Musshoff, Benno Hartung
Aims Phosphatidylethanol (PEth) is only formed when ethanol is present in blood. This direct alcohol marker has been widely discussed, including the minimum amount of ethanol being necessary to form as much PEth as to exceed the threshold of 20 ng/mL in previously PEth negative subjects. In order to corroborate hitherto existing results, a drinking study including 18 participants after a 3-week alcohol