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Are long-term alcohol health harms overlooked in individuals with illicit drug problems? Alcohol-related morbidity and mortality in a Danish cohort of clients in residential rehabilitation for drug use disorders. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-09-21 Julie Brummer,Timo Lehmann Kvamme,Birgitte Thylstrup,Morten Hesse
AIMS This study described the burden of alcohol-related morbidity and mortality among those who had been enrolled in residential treatment for drug use disorders in Denmark and investigated whether self-reported information on alcohol use provided at treatment admission can be used to assess risk for future serious alcohol-related harms. METHODS At baseline (entry in drug use disorder treatment during
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Naltrexone augmented with prazosin for alcohol use disorder: results from a randomized controlled proof-of-concept trial Alcohol Alcohol. (IF 2.1) Pub Date : 2024-09-14 Tracy L Simpson, Carol Achtmeyer, Lisa Batten, Joseph Reoux, Jane Shofer, Elaine R Peskind, Andrew J Saxon, Murray A Raskind
Aims We conducted a proof-of-concept randomized controlled trial of the mu-opioid receptor antagonist, naltrexone, augmented with the alpha-1 adrenergic receptor antagonist, prazosin, for alcohol use disorder in veterans. We sought a signal that the naltrexone plus prazosin combination regimen would be superior to naltrexone alone. Methods Thirty-one actively drinking veterans with alcohol use disorder
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Alcohol pharmacotherapy dispensing trends in Australia between 2006 and 2023 Alcohol Alcohol. (IF 2.1) Pub Date : 2024-09-07 Ebony Quintrell, Amy Page, Caitlin Wyrwoll, Alexander Larcombe, David B Preen, Osvaldo Almeida, Christopher Etherton-Beer, Erin Kelty
Aims This study aimed to investigate acamprosate and naltrexone dispensing patterns in Australia. Methods A 10% representative sample of medications subsidized by the Australian Pharmaceutical Benefits Scheme (PBS) was used to identify individuals who were dispensed naltrexone or acamprosate between January 2006 and December 2023. Data were used to examine concurrent dispensing, medication switching
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Chronic binge alcohol mediated hepatic metabolic adaptations in SIV-infected female rhesus macaques Alcohol Alcohol. (IF 2.1) Pub Date : 2024-09-05 Eden M Gallegos, Liz Simon, Patricia E Molina
Aims As the interactions of alcohol and HIV/SIV infection and their impact on liver metabolic homeostasis remain to be fully elucidated, this study aimed to determine alcohol-mediated hepatic adaptations of metabolic pathways in SIV/ART-treated female rhesus macaques fed a nutritionally balanced diet. Methods Macaques were administered chronic binge alcohol (CBA; 13–14 g ethanol/kg/week for 14.5 months;
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Alcohol use disorder is associated with a lower risk of in-hospital mortality in type A aortic dissection repair: a population-based study of National Inpatient Sample from 2015–2020 Alcohol Alcohol. (IF 2.1) Pub Date : 2024-09-02 Renxi Li, Stephen J Huddleston, Deyanira J Prastein
Background While alcohol consumption is implicated in the development of aortic dissection, the impact of alcohol use disorder (AUD) on the outcomes of type A aortic dissection (TAAD) repair is still largely unexplored. This study aimed to conduct a comprehensive, population-based analysis of effect of AUD on in-hospital outcomes following TAAD repair using National/Nationwide Inpatient Sample, the
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The protection motivation theory as an explanatory model for intention to use alcohol protective behavioral strategies related to the manner of drinking among young adults Alcohol Alcohol. (IF 2.1) Pub Date : 2024-08-30 Bella M González-Ponce, José Carmona-Márquez, Angelina Pilatti, Carmen Díaz-Batanero, Fermín Fernández-Calderón
Aims This study aimed to prospectively examine the explanatory value of the protection motivation theory (PMT) for the intention to use manner of drinking protective behavioral strategies (MD PBS) and to explore its invariance across genders. Method A targeted sampling procedure was used to recruit 339 young adults in the community (Mage = 21.1; SD = 2.21; female = 50.7%) who completed baseline and
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Perception is reality: qualitative insights into how consumers perceive alcohol warning labels Alcohol Alcohol. (IF 2.1) Pub Date : 2024-08-19 Joya Kemper, Anna Rolleston, Kristen Matthews, Katie Garner, Bodo Lang, Yannan Jiang, Cliona Ni Mhurchu, Natalie Walker
Aims This study explores perspectives of on-pack alcohol warning labels, and how they might influence alcohol purchase and/or consumption behavior to inform culturally appropriate label design for effective behavior change. Methods New Zealand participants ≥18 years, who reported having purchased and consumed alcoholic beverages in the last month were recruited via a market research panel and grouped
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Triple network resting-state functional connectivity patterns of alcohol heavy drinking Alcohol Alcohol. (IF 2.1) Pub Date : 2024-08-12 Mahmoud Elsayed, Emma Marsden, Tegan Hargreaves, Sabrina K Syan, James MacKillop, Michael Amlung
Aims Previous neuroimaging research in alcohol use disorder (AUD) has found altered functional connectivity in the brain’s salience, default mode, and central executive (CEN) networks (i.e. the triple network model), though their specific associations with AUD severity and heavy drinking remains unclear. This study utilized resting-state fMRI to examine functional connectivity in these networks and
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Needs of female outpatients with alcohol use disorder: data from an Italian study Alcohol Alcohol. (IF 2.1) Pub Date : 2024-08-09 Teo Vignoli, Maria Caterina Staccioli, Maristella Salaris, Samantha Sanchini, Elisa Martino, Lorena Rigoli, Francesco Salis, Fabio Caputo, Liana Fattore, Roberta Agabio
Aims Alcohol use disorder (AUD) is a common mental disorder characterized by sex-gender differences (SGDs). The present study was aimed at evaluating attitudes displayed by Italian AUD treatment services towards investigating the presence of SGDs in their patients and implementing gender-specific treatments for female AUD patients. Methods Potential SGDs were initially investigated in a sample of AUD
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Alcohol hangover recognized as a separate medical condition in ICD-11: could effective treatments be counterproductive? Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-30 Emina Išerić, Andrew Scholey, Joris C Verster, Analia G Karadayian
Recently, the alcohol hangover has been accepted by the International Classification of Diseases – 11th revision as a separate ‘child entity’ to alcohol intoxication, a disease. Currently there are no marketed hangover treatments with support for clinical efficacy. Furthermore, diverse perspectives exist among healthcare professionals, policymakers, and alcohol consumers regarding the necessity and
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Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-25 Colleen McGowan, Monika Krah, Nia Fogelman, Dongju Seo, Rajita Sinha
Aims Peripheral cortisol represents one biological measure of the hypothalamic–pituitary–adrenal (HPA) axis, a significant component of the stress system, which is altered by chronic alcohol consumption. However, whether heavy alcohol use affects the HPA axis differentially between the sexes and whether basal cortisol levels are a biomarker of prospective alcohol intake is unknown. Methods We recruited
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Involvement of the gut microbiome-brain axis in alcohol use disorder Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-24 Sophie Leclercq
The human intestine is colonized by a variety of microorganisms that influence the immune system, the metabolic response, and the nervous system, with consequences for brain function and behavior. Unbalance in this microbial ecosystem has been shown to be associated with psychiatric disorders, and altered gut microbiome composition related to bacteria, viruses, and fungi has been well established in
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AUDIT C compared to PEth in middle-aged volunteers Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-24 Marie Fredriksson, Mårten Werner
Aims To compare Alcohol Use Disorders Identification Test (AUDIT C) to phosphatidylethanol (PEth) in middle-aged randomly selected volunteers. Apply previously suggested lower cut-offs for PEth using moderate alcohol intake according to AUDIT C as a reference. Methods Within the Swedish CardioPulmonary BioImage Study, 2255 middle-aged (50–64 years of age) volunteers in northern Sweden participated
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Individualized treatment effects of a digital alcohol intervention and their associations with participant characteristics and engagement Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-22 Joel Crawford, Elizabeth S Collier, Marcus Bendtsen
Aims Conditional average treatment effects are often reported in intervention studies, in which assumptions are made regarding how effects are similar across a heterogeneous sample. Nonetheless, differing factors, such as genetics, age, and sex, can impact an intervention’s effect on outcomes. The study aimed to estimate the individualized effects of a digital alcohol intervention among individuals
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Correction to: Alcohol metabolism in alcohol use disorder: a potential therapeutic. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-21
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Prevalence of work hour alcohol use and associated factors among psychiatrists in China. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-21 Licong Jiang,Elizabeth McCord,Huanzhong Liu,Yuanli Liu,Feng Jiang,Yi-Lang Tang
BACKGROUND Since 2012, work-hour alcohol use (WHAU) has been prohibited in China. However, there is a lack of national data on WHAU among healthcare workers, including psychiatrists. METHODS We collected data from psychiatrists in 41 tertiary psychiatric hospitals using an online questionnaire, which included demographics, work-related factors, WHAU, and the Alcohol Use Disorder Identification Test-Consumption
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Pro-atherogenic medical conditions are associated with widespread regional brain metabolite abnormalities in those with alcohol use disorder. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-21 Timothy C Durazzo,Eric P Kraybill,Lauren H Stephens,April C May,Dieter J Meyerhoff
AIMS Widespread brain metabolite abnormalities in those with alcohol use disorder (AUD) were reported in numerous studies, but the effects of the pro-atherogenic conditions of hypertension, type 2 diabetes mellitus, hepatitis C seropositivity, and hyperlipidemia on metabolite levels were not considered. These conditions were associated with brain metabolite abnormalities in those without AUD. We predicted
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Social disparity is associated with an increased risk of acute and chronic pancreatitis. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-21 Ulrik Becker,Amalie Timmermann,Ola Ekholm,Asbjørn Mohr Drewes,Srdan Novovic,Camilla Nøjgaard,Søren Schou Olesen,Janne Schurmann Tolstrup
AIM To study social disparity in acute pancreatitis (AP) and chronic pancreatitis (CP).We also aimed at exploring whether an interaction exists between alcohol intake and socioeconomic factors. METHODS Prospective cohort study based on data from 271 696 men and women participating in the Danish National Health Surveys 2010, and 2013. Information on alcohol and smoking parameters, body mass index (BMI)
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A rapid literature review of the effect of alcohol marketing on people with, or at increased risk of, an alcohol problem Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-08 Rachael L Murray, Jo Leonardi-Bee, Alexander Barker, Olivia Brown, Tessa Langley
Aims To explore the effect or potential effect of alcohol marketing in people with an alcohol use disorder, in recovery from an alcohol use disorder, and hazardous and harmful drinkers. Methods Relevant literature was identified by searching Medline (OVID), EMBASE (OVID), and PsycINFO (OVID) and relevant websites. Both quantitative and qualitative studies were eligible for inclusion. A narrative approach
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Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use Alcohol Alcohol. (IF 2.1) Pub Date : 2024-07-02 Katelyn T Kirk-Provencher, Matthew E Sloan, Keinada Andereas, Cooper J Erickson, Rosa H Hakimi, Anne E Penner, Joshua L Gowin
Aims Reward processing and regulation of emotions are thought to impact the development of addictive behaviors. In this study, we aimed to determine whether neural responses during reward anticipation, threat appraisal, emotion reactivity, and cognitive reappraisal predicted the transition from low-level to hazardous alcohol use over a 12-month period. Methods Seventy-eight individuals aged 18–22 with
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Advancing research: a commentary on the untapped potential of acceptance and commitment therapy in alcohol use disorder treatment Alcohol Alcohol. (IF 2.1) Pub Date : 2024-06-28 Nicolas Garel, Kimberly L Brodsky, Michael J Ostacher
Alcohol use disorder poses a significant global health threat, with profound consequences for individuals, families, and communities, necessitating continued exploration of novel treatment approaches. Acceptance and Commitment Therapy, an evidence-based approach for various mental health disorders, offers promise in addressing alcohol use disorder as well, but controlled trials are lacking, highlighting
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Drinking contexts, coping motive, simultaneous cannabis use, and high-intensity drinking among adults in the United States Alcohol Alcohol. (IF 2.1) Pub Date : 2024-06-08 Won Kim Cook, Camillia K Lui, Thomas K Greenfield, Meenakshi Subbaraman, Libo Li, William C Kerr
Aims High-intensity drinking (HID), extreme drinking considerably above the level of heavy episodic drinking (HED), is associated with long-term health and social consequences. There is limited understanding of HID beyond young adulthood. This study aims to identify concurrent risk factors for HID, comparing age differences among all adults. Methods Multinomial logistic and linear regression modeling
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Profiles and the impact of affective temperaments on alcohol use disorder: a cross-sectional study Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-30 Kazuhiro Kurihara, Munenaga Koda, Yu Zamami, Hotaka Shinzato, Yoshikazu Takaesu, Tsuyoshi Kondo
Aims This study aimed to explore the profiles and impact of affective temperaments, together with social and clinical backgrounds, including affective symptoms, in patients with alcohol use disorder (AUD). Methods This study included 314 low-risk drinkers and 257 patients with AUD. To assess affective temperament, we used the short version of the temperament evaluation of Memphis, Pisa, Paris, and
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Alcohol effects on interoception shape expectancies and subjective effects: a registered report using the heart rate discrimination task Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-24 Mateo Leganes-Fonteneau
Aims Alcohol acutely impacts interoceptive processes, which in turn affect the perception of alcohol effects and the development of alcohol expectancies. However, previous research is limited by the tools used to measure cardiac interoception and subjective alcohol effects. This registered report proposes a re-examination of previous findings using a state-of-the-art measure of interoceptive capacity
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Prevalence, sociodemographic, and clinical correlates of underweight in a sample of Chinese male alcohol-dependent patients Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-22 Huanfen Li, Lifang Zhu, Jie Zhang, Jun Xue
Background Underweight is a significant symptom in alcohol-dependent patients, yet few studies have examined underweight in Chinese male patients. The current study aimed to identify the prevalence, sociodemographic, and clinical correlates of underweight in Chinese male patients with alcohol dependency. Methods In this cross-sectional study, 405 male inpatients with alcohol dependence and 383 healthy
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Characterizing reward and relief/habit drinking profiles in a study of naltrexone, varenicline, and placebo. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Annabel Kady,Erica N Grodin,Lara A Ray
INTRODUCTION This study aims to clarify differences in mood, craving, and treatment response between reward and relief/habit individuals in a study of naltrexone, varenicline, and placebo. We hypothesized that relief/habit individuals would have a poorer mood during early abstinence and higher levels of alcohol craving than reward individuals. We hypothesized that reward individuals would demonstrate
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Relationship between alcohol intake based on daily smartphone-reported consumption and PEth concentrations in healthy volunteers. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Trine Finanger,Katrine Melby,Olav Spigset,Trine N Andreassen,Stian Lydersen,Ragnhild Bergene Skråstad
AIMS To investigate the association between alcohol consumption registered daily with a digital smartphone-based diary and concentration of phosphatidylethanol (PEth) 16:0/18:1 in a population without a known alcohol use disorder (AUD), and evaluate whether prospective registration of alcohol consumption is better than retrospective registration and if the association between alcohol intake and PEth
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An assessment of beliefs about mental health care among community-based adults with severe, untreated alcohol use disorder. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Morica Hutchison,Sarah Szafranski,Caitlin Titus,Beau Abar,Kenneth R Conner,Stephen Maisto,Tracy Stecker
OBJECTIVE Alcohol use disorder (AUD) is among the most prevalent substance use disorders in the USA. Despite availability of effective interventions, treatment initiation and engagement remain low. Existing interventions target motivation and practical barriers to accessing treatment among individuals established within treatment systems. In contrast, Cognitive Behavioral Therapy for Treatment-Seeking
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Addressing causal relationship between drinking behavior and metabolic syndrome: one-sample Mendelian randomization analysis. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Chuan-Wei Yang,Yu-Syuan Wei,Chia-Ing Li,Chiu-Shong Liu,Chih-Hsueh Lin,Cheng-Chieh Lin,Tsai-Chung Li
AIMS Alcohol drinking is associated with central obesity, hypertension, and hyperlipidemia, which further causes metabolic syndrome (MetS). However, prior epidemiological studies on such associations lack experimental evidence for a causal relationship. This study aims to explore the causal relationship between drinking behavior and MetS in Taiwan population by using Mendelian randomization (MR) analysis
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IQ in high school as a predictor of midlife alcohol drinking patterns. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Natalie Druffner,Donald Egan,Swetha Ramamurthy,Justin O'Brien,Allyson Folsom Davis,Jasmine Jack,Diona Symester,Kelston Thomas,Jayme M Palka,Vishal J Thakkar,Edson Sherwood Brown
AIMS The aim of the present study was to assess the relationship between adolescent IQ and midlife alcohol use and to explore possible mediators of this relationship. METHODS Study data were from 6300 men and women who participated in the Wisconsin Longitudinal Study of high-school students graduating in 1957. IQ scores were collected during the participants' junior year of high school. In 2004, participants
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Effectiveness of a self-help guide during a temporary alcohol abstinence challenge: a randomized controlled trial. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Annelien Esselink,Andrea D Rozema,Nathalie Kools,Tim Van Den Berk,Rob H L M Bovens,Jolanda J P Mathijssen
BACKGROUND The popularity of temporary abstinence challenges (TACs) concerning alcohol consumption is increasing. Support is found to be essential for participants to help them get through a challenge. This study aimed to evaluate the additional effect of a self-help guide, based on health behaviour theories and behaviour change techniques, on (i) successful completion of a TAC and (ii) changes in
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Sex differences in neuronal activation in the cortex and midbrain during quinine-adulterated alcohol intake Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-14 Miranda E Arnold, Jesse R Schank
Aims Continued alcohol consumption despite negative consequences is a core symptom of alcohol use disorder. This is modeled in mice by pairing negative stimuli with alcohol, such as adulterating alcohol solution with quinine. Mice consuming alcohol under these conditions are considered to be engaging in aversion-resistant intake. Previously, we have observed sex differences in this behavior, with females
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Reward, relief, and habit drinking profiles in treatment seeking individuals with an AUD Alcohol Alcohol. (IF 2.1) Pub Date : 2024-05-10 Erica N Grodin, Wave-Ananda Baskerville, Lindsay R Meredith, Steven Nieto, Lara A Ray
Aims This study aimed to compare reward, relief, and habit treatment-seeking individuals on recent drinking, alcohol use disorder (AUD) phenomenology, and mood. The second aim of the study was to evaluate the predictive validity of reward, relief, and habit profiles. Method Treatment-seeking individuals with an AUD (n = 169) were recruited to participate in a medication trial for AUD (NCT03594435)
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A confirmatory factor analysis of a revised motives for playing drinking games (MPDG-33) scale among university students in the United States Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-30 Byron L Zamboanga, Amie R Newins, Janine V Olthuis, Jennifer E Merrill, Heidemarie Blumenthal, Su Yeong Kim, Timothy J Grigsby, Patrick McClain, Dennis McChargue, Miguel Ángel Cano
Aim Participating in a drinking game (DG) is common practice among university students and can increase students’ risk for heavy drinking. Given the theoretical link between motivations to drink and alcohol use, careful consideration should be given to students’ motivations to play DGs. In this study, we examined the factor structure, internal consistency, and concurrent validity of a revised version
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Investigating the relationship between prenatal alcohol exposure and children’s behavioural and emotional development: analysis of the Growing Up in New Zealand study Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-28 Joanna Ting Wai Chu, Jessica McCormack, Yannan Jiang, Daniel Walsh, Holly Wilson, Samantha Marsh, Fiona Langridge, Chris Bullen
Aims To examine the relationship between prenatal alcohol exposure (PAE) and children’s behavioural and emotional development in a large generalizable sample of women and their children in Aotearoa New Zealand. Methods Using data from the Growing Up in New Zealand longitudinal cohort, we investigated the relationship between maternal PAE and behavioural and emotional development in 8-year-old children
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Alcohol to-go sales policies at on-premise drinking establishments near large public US universities during the COVID-19 pandemic Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-18 Erika M Rosen, Andrew Walker, Pamela J Trangenstein, Cassidy R LoParco, Melvin D Livingston, Adam E Barry, Matthew E Rossheim
Aims Sweeping policy changes during the COVID-19 pandemic increased alcohol availability through permitted to-go sales, potentially posing unique risks to college students. While to-go sales may make binge drinking more convenient, little remains known about these practices. Therefore, this study aimed to assess whether drinking establishments’ to-go sales practices are associated with their other
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Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-12 Christian C Garcia, Dylan K Richards, Felicia R Tuchman, Kevin A Hallgren, Henry R Kranzler, Henri-Jean Aubin, Stephanie S O’Malley, Karl Mann, Arnie Aldridge, Michaela Hoffman, Raymond F Anton, Katie Witkiewitz
Aims Among individuals with alcohol use disorder (AUD), sleep disturbances are pervasive and contribute to the etiology and maintenance of AUD. However, despite increased attention toward the relationship between alcohol use and sleep, limited empirical research has systematically examined whether reductions in drinking during treatment for AUD are associated with improvements in sleep problems. Methods
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Pulmonary symptoms associated with heavy alcohol consumption among people living with HIV: an analysis of the NHANES 1999–2010 Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-06 Moses New-Aaron, Mohleen Kang, Samantha M Yeligar
Aim This matched case–control study aimed to provide epidemiologic evidence of increased burden of respiratory symptoms and pulmonary function decline among people living with human immunodeficiency virus (HIV) and a history of heavy alcohol consumption. Methods Cases were participants with HIV (PWH; n = 75, 33%), and controls were participants without HIV (PWoH; n = 150, 67%). PWH were matched to
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How frequently is alcohol advertised on television in Canada?: A cross-sectional study Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-04 Elise Pauzé, Adena Pinto, Monique Potvin Kent
Aims Alcohol marketing is a commercial driver of alcohol use, including among youth. This study sought to quantify and characterize alcohol advertising on broadcast television in Canada. Methods Open-source television program logs for January to December 2018 submitted to the Canadian Radio-television and Telecommunications Commission by 147 stations with alcohol advertisements were analyzed. Results
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Positive allosteric modulators of the GABAB receptor: a new class of ligands with therapeutic potential for alcohol use disorder Alcohol Alcohol. (IF 2.1) Pub Date : 2024-04-03 Giancarlo Colombo
Background Positive allosteric modulators (PAMs) of the GABAB receptor constitute a new class of GABAB-receptor ligands. GABAB PAMs reproduce several pharmacological effects of the orthosteric GABAB receptor agonist, baclofen, although displaying a better safety profile. Aims This paper reviews the reducing or, frequently, even suppressing effects of all GABAB PAMs tested to date on multiple alcohol-related
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Isolation and loneliness as pathways to heavy drinking early in the pandemic Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-28 Michael Fendrich, Jessica Becker, Beth S Russell, Crystal L Park
Introduction social isolation and forced quarantines during the early phases of the COVID-19 pandemic coincided with a steep and persistent rise in alcohol consumption among US adults. While the association between loneliness and drinking is well established, less is known about the impact of social isolation (a known correlate of loneliness) and the interplay between these two variables in relation
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Acute alcohol ingestion decreases the work done above the end-test power during a 3-min all-out cycling exercise Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-26 Danilo França Conceição dos Santos, Samuel Penna Wanner, Rodolfo Ferreira de Paula, Gustavo Oliveira Zanetti, Donizete Cícero Xavier de Oliveira, Fabio Lera Orsatti, Francisco Teixeira-Coelho
Introduction Alcohol ingestion influences metabolism during a subsequent exercise session, as evidenced by increased blood lactate concentration during fixed-intensity exercise. Therefore, augmented blood concentrations of alcohol may interfere with the anaerobic metabolism during high-intensity, short-duration exercise bout, thereby leading to impaired athletic performance. Objective This study investigated
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Effect of rifampicin on TLR4-signaling pathways in the nucleus accumbens of the rat brain during abstinence of long-term alcohol treatment Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-23 Marat Airapetov, Sergei Eresko, Polina Ignatova, Andrei Lebedev, Evgenii Bychkov, Petr Shabanov
Aims The treatment with the antibiotic rifampicin (Rif) led to a decrease in the frequency of neurodegenerative pathologies. There are suggestions that the mechanism of action of Rif may be mediated by its effect on toll-like receptor (TLR)4-dependent pathways. We evaluated the expression status of TLR4-dependent genes during abstinence from long-term alcohol treatments in the nucleus accumbens (NAc)
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Associations between alcohol taxes and varied health outcomes among women of reproductive age and infants Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-18 Meenakshi S Subbaraman, Alex Schulte, Nancy F Berglas, William C Kerr, Sue Thomas, Ryan Treffers, Guodong Liu, Sarah C M Roberts
Objective No studies have examined whether alcohol taxes may be relevant for reducing harms related to pregnant people’s drinking. Method We examined how beverage-specific ad valorem, volume-based, and sales taxes are associated with outcomes across three data sets. Drinking outcomes came from women of reproductive age in the 1990–2020 US National Alcohol Surveys (N = 11 659 women $\le$ 44 years);
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Educational inequalities and alcohol-related consequences in Brazil. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-16 Leandro Machado Oliveira,Flávio Fernando Demarco,Fabrício Batistin Zanatta
AIMS This study aimed to test whether the alcohol harm paradox (AHP) is observed in Brazil by investigating (i) the association between educational attainment and alcohol-related consequences (ARC) and (ii) the contribution of average alcohol volume consumed (AVC), past-month heavy episodic drinking (HED), smoking, body mass index (BMI), and depression in accounting for the disparities in ARC. METHODS
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High-density lipoprotein (HDL) as an indicator for alcohol use in a psychiatrically ill population. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-16 Nicole M Benson,Amin Yakubu,Boyu Ren,Carol Aboud,Victoria Vargas,Shelly F Greenfield,Alisa B Busch
AIMS To examine the cross sectional and longitudinal associations between the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) and differences in high-density lipoprotein (HDL) in a psychiatrically ill population. METHODS Retrospective observational study using electronic health record data from a large healthcare system, of patients hospitalized for a mental health/substance use disorder
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Keeping you connected or keeping you addicted? Weekly use of social media platforms is associated with hazardous alcohol use and problem gambling among adults. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-16 Iina Savolainen,Atte Oksanen
AIMS A wide variety of social media platforms exist, each offering tailored solutions to attract specific target audiences based on their social media needs and interests. This diversity may pose a risk factor for the development or perpetuation of harmful behaviors. Research has established a connection between social media use and increased health risk behaviors. This six-wave exploratory longitudinal
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Exploring the relationship between solitary drinking and living without other adults on alcohol consumption during the COVID-19 pandemic. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-16 Yvette Mojica-Perez,Bree Willoughby,Dan Anderson-Luxford,Claire Wilkinson,Emmanuel Kuntsche,Sarah Callinan,Alison Ritter
AIMS The COVID-19 pandemic presents the opportunity to learn about solitary drinking as many people were forced to spend time at home. The aim of this study is to examine the relationship between solitary drinking and living without other adults on alcohol consumption. METHODS A longitudinal study with four survey waves (between May and November 2020) obtained seven-day drinking diary data from Australian
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Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study. Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-16 Benedicte M Jørgenrud,Camilla C Bråthen,Jo Steinson Stenehjem,Thomas Kristiansen,Leiv Arne Rosseland,Stig Tore Bogstrand
INTRODUCTION Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further. Phosphatidylethanol (PEth) 16:0/18:1 is a biomarker used to determine alcohol consumption the previous 3-4 weeks. The aim was to investigate the prevalence of chronic alcohol use in trauma patients, as determined by PEth 16:0/18:1
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Elevated liver enzymes and fasting glucose levels correlate with neuropathy in patients diagnosed with alcohol use disorder independently of the blood thiamine levels Alcohol Alcohol. (IF 2.1) Pub Date : 2024-03-12 Michail Papantoniou, Thomas Zampelis, Panagiotis Kokotis, Elias Tzavellas, Thomas Paparrigopoulos, Stylianos Chatzipanagiotou, Chrysoula Nikolaou, Michail Rentzos
Aims Chronic alcohol consumption is well known to cause peripheral neuropathy, affecting both small and large nerve fibers. The aim of this study was to correlate biochemical and neurophysiological findings and investigate possible biomarkers and risk factors for pathogenetic mechanisms of neuropathy in patients diagnosed with alcohol use disorder (AUD). Methods Ninety patients diagnosed with AUD were
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Alcohol-related cognitive impairments in patients with and without cirrhosis Alcohol Alcohol. (IF 2.1) Pub Date : 2024-02-17 Bernard Angerville, Marie-Alix Jurdana, Margaret P Martinetti, Ruxandra Sarba, Éric Nguyen-Khac, Mickael Naassila, Alain Dervaux
Aims up to 80% of patients with alcohol use disorder display cognitive impairments. Some studies have suggested that alcohol-related cognitive impairments could be worsened by hepatic damage. The primary objective of this study was to compare mean scores on the Brief Evaluation of Alcohol-Related Neurocognitive Impairments measure between alcohol use disorder patients with (CIR+) or without cirrhosis
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A social media intervention for high-intensity drinking among emerging adults: a pilot randomized controlled trial Alcohol Alcohol. (IF 2.1) Pub Date : 2024-02-16 Erin E Bonar, Chiu Y Tan, Anne C Fernandez, Jason E Goldstick, Lyndsay Chapman, Autumn R Florimbio, Maureen A Walton
Aims High-intensity drinking (HID) is a pattern of risky drinking defined as at least 8 drinks (for women) or 10 drinks (for men) in a single episode. Individuals engaged in HID may be at greater risk for consequences, necessitating tailored interventions. Herein, we report the feasibility and acceptability of a social media-delivered 8-week intervention for emerging adults with recent HID. Methods
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Patterns of publicly funded naltrexone use among patients diagnosed with alcohol use disorder in Ontario Alcohol Alcohol. (IF 2.1) Pub Date : 2024-02-01 Nima Tourchian, Daniel McCormack, Pamela Leece, Mina Tadrous, Tara Gomes
Aims Naltrexone is recommended first-line to manage alcohol use disorder (AUD). With previous studies indicating poor retention on naltrexone, we determined duration of naltrexone use and assessed the association between prescription setting and time to discontinuation in Ontario. Methods We conducted a retrospective population-based cohort study among Ontario public drug beneficiaries diagnosed with
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The criminal justice system in alcohol use treatment: a nationwide analysis of racial disparities in treatment referral and completion Alcohol Alcohol. (IF 2.1) Pub Date : 2024-01-24 Madeline R Stenersen, MacKenzie Peltier, Sherry A McKee
Background Alcohol use and the criminal justice (CJ) system have long been integrally connected in the United States and have both disproportionally impacted Communities of Color. Despite this connection, scholarly literature has largely focused on substance use as a whole, and little literature has examined the influence of race on CJ referral to alcohol treatment and treatment outcomes. Methods A
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Baclofen in the treatment of alcohol use disorder: tailored doses matter Alcohol Alcohol. (IF 2.1) Pub Date : 2024-01-24 Renaud de Beaurepaire, Philippe Jaury
Aims To address the question of tailored baclofen prescribing in alcohol use disorder (AUD) in relation to dose-dependent efficacy and the potential danger of high doses and to provide suggestions for the use of high doses of baclofen in the treatment of AUD. The context is the approvement in France of baclofen in the treatment of AUD without dose limitation, making French physicians, who usually prescribe
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A high-resolution PheWAS approach to alcohol-related polygenic risk scores reveals mechanistic influences of alcohol reinforcing value and drinking motives Alcohol Alcohol. (IF 2.1) Pub Date : 2024-01-23 Wei Q Deng, Kyla Belisario, Joshua C Gray, Emily E Levitt, James MacKillop
Aims This study uses a high-resolution phenome-wide approach to evaluate the motivational mechanisms of polygenic risk scores (PRSs) that have been robustly associated with coarse alcohol phenotypes in large-scale studies. Methods In a community-based sample of 1534 Europeans, we examined genome-wide PRSs for the Alcohol Use Disorders Identification Test (AUDIT), drinks per week, alcohol use disorder
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Development of the lyrics-based deep learning algorithm for identifying alcohol-related words (LYDIA) Alcohol Alcohol. (IF 2.1) Pub Date : 2024-01-18 Abraham Albert Bonela, Zhen He, Dan-Anderson Luxford, Benjamin Riordan, Emmanuel Kuntsche
Background Music is an integral part of our lives and is often played in public places like restaurants. People exposed to music that contained alcohol-related lyrics in a bar scenario consumed significantly more alcohol than those exposed to music with less alcohol-related lyrics. Existing methods to quantify alcohol exposure in song lyrics have used manual annotation that is burdensome and time intensive
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Meeting-makers make meaning: alcoholics anonymous participation and personal meaningfulness Alcohol Alcohol. (IF 2.1) Pub Date : 2024-01-18 Benjamin L Thompson, Nasim Maleki, John F Kelly, Marlene Oscar-Berman
Aims The central aim of this study was to determine whether intentional, voluntary alcoholics anonymous (AA) participation showed any independent association with affect, over and above that which has been observed in association with other recovery-related behaviors, such as abstinence, among individuals with a history of alcohol use disorder. Additionally, we sought to determine the nature of the