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Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer’s Disease Severity J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-09-14 Fatma E. Algul, Yuksel Kaplan
IntroductionInflammatory processes and neurodegeneration are common features of Alzheimer's disease (AD). The systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are easily accessible, cost-effective prognostic indicators of inflammation status. We assessed the diagnostic value of SII and compared the efficacies of NLR, PLR, and SII
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Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson’s Disease J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-09-08 Salih Cayir, Melike Tezel, David Matuskey
ObjectiveSocial factors can influence the brain’s dopaminergic function. This study investigated the relationship between socioenvironmental factors and dopamine transporter (DaT) availability in healthy individuals (n = 74) and those with Parkinson’s disease (PD) (n = 240).MethodsAll single photon emission computed tomography (SPECT) DaT data and clinical data used in this study were obtained from
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Treatment of Neuropsychiatric Symptoms in Parkinson’s Disease With Botulinum Toxin A: A 12 week Randomized, Double-Blind, Placebo-Controlled Trial J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-09-04 Xiaofeng Zhu, Ming Wei, Lijun Wang, Qiang Tong, Xiu Yang, Qiu Han
ObjectiveThe study aimed to evaluate the impact of Botulinum toxin A (BoNT/A) on neuropsychiatric symptoms in Parkinson’s disease (PD) patients.MethodsA total of 125 PD patients and an equal number of age- and gender-matched healthy controls were involved. Mental health status was assessed using the Cornell Medical Index (CMI) self-assessment questionnaire. Sixty-four PD patients exhibiting neuropsychiatric
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Attitudes Towards Dementia Among a Diverse Group of Refugees Resettled in the United States J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-09-04 Dahlia A. Kaki, Lana Bridi, Purity Mwendwa, Maryam Aso, Rawnaq Behnam, Nissma Bencheikh, Behnan Albahsahli, Xara Khan, Raghad Aljenabi, Alissa Bernstein Sideman, Alison Moore, Tala Al-Rousan
BackgroundForced migration results in exposure to trauma, interrupted access to healthcare, and loss of social support and may increase dementia risk. Literature on refugees’ knowledge of dementia and its risk factors is scant. This study investigates refugee perspectives on dementia and their access to cognitive healthcare in the United States (US).MethodsWe conducted 6 focus groups and 30 individual
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The Associations of Sensory Impairment With 10-Year Risk of Dementia and Alzheimer’s Disease: The Health and Retirement Study, 2010-2020 J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-08-26 Kun Li, Rahul Ghosal, Donglan Zhang, Yike Li, Matthew C. Lohman, Monique J. Brown, Anwar T. Merchant, Chih-Hsiang Yang, Jean Neils-Strunjas, Daniela B. Friedman, Jingkai Wei
BackgroundStudies have examined the association between dual sensory impairment and late-life cognitive outcomes in the U.S with inconsistent findings.ObjectiveTo examine the associations between sensory impairment and 10-year risk of dementia or Alzheimer’s disease among U.S. adults aged ≥ 50.MethodsA prospective cohort study based on the Health and Retirement Study from 2010 to 2020. Individuals
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Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-08-24 Yongjun Tan, Xiaojun Jing, Jiani Wang, Li Zhou, Yilin Wang, Hua Zhang, Qin Yang
ObjectiveTo conduct the association between vitamin D levels in the acute phase of stroke and post-stroke depression (PSD) in stroke patients.MethodsFive international databases (PubMed, Web of Science, Embase, Ovid MEDLINE(R), Cochrane Library) and one Chinese database (Wanfang Data) were searched for observational studies in any language reporting on PSD and vitamin D levels tested in the acute phase
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A Comparison of Test-Retest Reliability and Practice Effects of Short Portable Mental State Questionnaire and Montreal Cognitive Assessment in Patients with Stroke J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-07-24 Ta-Cheng Chen, Ya-Chen Lee, Yi-Ching Wang, Ton-Lin Hsieh, Mei-Hsiang Chen
ObjectiveTo compare the test-retest reliabilities and minimal detectable change (MDC) of the Short Portable Mental State Questionnaire (SPMSQ) and the Montreal Cognitive Assessment (MoCA) in patients with stroke.Methods63 patients were recruited from 1 medical center. The SPMSQ and MoCA were administered twice, 2 weeks apart.ResultsBoth measures showed high intraclass correlation coefficients (SPMSQ:
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Dementia Specialty Care Clinicians’ Perspectives on Their Role in the Dementia Diagnostic Process and Diagnostic Disclosure J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-07-24 Alissa B. Sideman, Krista L. Harrison, Sarah B. Garrett, Joanna Paladino, Georges Naasan, Christine S. Ritchie
BackgroundDelivering a diagnosis of Alzheimer’s disease and related dementias (ADRD) can be challenging not just for patients and families, but also for clinicians. Our objective was to understand dementia specialty care clinicians’ perspectives on their role in diagnosis and diagnostic disclosure in dementia.MethodsQualitative interviews with clinicians from a specialty tertiary dementia care center
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Two-Year Longitudinal Outcomes of Subjective Cognitive Decline in Hispanics Compared to Non-hispanic Whites J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-07-23 Carolina Boza-Calvo, Arline Faustin, Yian Zhang, Anthony Q. Briggs, Mark A. Bernard, Omonigho M. Bubu, Julia A. Rao, Lindsey Gurin, Sakina Ouedraogo Tall, Ricardo S. Osorio, Karyn Marsh, Yongzhao Shao, Arjun V. Masurkar
BackgroundSubjective cognitive decline (SCD), considered a preclinical dementia stage, is less understood in Hispanics, a high-risk group for dementia. We investigated SCD to mild cognitive impairment (MCI) progression risk, as well as baseline and longitudinal features of depressive symptoms, SCD complaints, and objective cognitive performance among Hispanics compared to non-Hispanic Whites (NHW)
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Pyridostigmine for the Management of Neurogenic Orthostatic Hypotension: A Systemic Review J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-07-23 Amanda C. Holder, Angela Dylewski, Jamie N. Brown
BackgroundPyridostigmine is hypothesized to improve neurogenic orthostatic hypotension (nOH) symptoms without causing or exacerbating supine hypertension. The objective of this review was to evaluate the safety and efficacy of pyridostigmine for management of nOH.MethodsA literature search of PubMed, Embase, and CENTRAL was performed in December 2023 for prospective trials with a placebo or active
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Implementing Arts on Prescription at Home for People Living With Dementia: A Hybrid-Effectiveness Feasibility Study J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-07-23 Claire MC O'Connor, Roslyn G Poulos, Michelle Heldon, Costanza Preti, Elizabeth Beattie, Christopher J Poulos
Arts on prescription at home (AoP@Home) is a participatory art-based approach involving a professional artist engaging a person with dementia (and their family carer) in art-making in their own home. This study evaluated the implementation of AoP@Home within a real-world community aged care context. A hybrid effectiveness-implementation design was used to simultaneously test both the AoP@Home intervention
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Modifiable and Non-Modifiable Risk Factors for Dementia Among Non-Hispanic White and Black Populations Aged 50-64 in the United States, 2006-2016 J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-07-22 Jingkai Wei, Matthew C. Lohman, Monique J. Brown, James W. Hardin, Chih-Hsiang Yang, Anwar T. Merchant, Daniela B. Friedman
Background and ObjectivesNon-Hispanic Black populations (NHB) have a significantly higher prevalence of dementia than non-Hispanic Whites in the U.S., and the underlying risk factors may play a role in this racial disparity. We aimed to calculate risk scores for dementia among non-Hispanic White (NHW) and non-Hispanic Black populations aged 50-64 years over a period of 10 years, and to estimate potential
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Clinical Staging for Personality Disorders in Older Adults J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-05-29 Jeroen A. P. Conjaerts, Arjan C. Videler, Roel Schepman, Iman Elfeddali, Erlene Rosowsky, Sebastiaan P. J. van Alphen
ObjectiveThis scientific research aimed to investigate the feasibility of implementing a clinical staging (CS) model for personality disorders (PDs) in older adults. The CS model could provide valuable insights into the life course of personality pathology, prognosis, and treatment decisions for PDs in older adults.Methods/DesignThe study employed an international Delphi methodology with three rounds
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Parkinson’s Disease: Coping Strategies, Cognitive Restructuring and Deep Brain Stimulation J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-05-27 Mylène Meyer, Sébastien Montel, Sophie Colnat-Coulbois, Solène Frismand, Pierre-Michel Llorca, Pierre Vidailhet, Raymund Schwan, Elisabeth Spitz
ObjectiveLess is known concerning the evolution of coping strategies before and after deep brain stimulation (DBS) in Parkinson’s disease (PD) patients.MethodsIn a randomized controlled trial, coping was measured with the neurological version of the CHIP (Coping with Health Injuries and Problem) and the BriefCOPE in PD patients before ( T1: DBS - 2 months) and after (T2: + 3 months, T3: + 6 months)
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Greater Apathy Associated With Selective Serotonin Reuptake Inhibitor Use in Parkinson’s Disease J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-05-23 Rachel N. Schade, Connor B. Etheridge, Lauren E. Kenney, Adrianna M. Ratajska, Katie Rodriguez, Francesca V. Lopez, Joshua Gertler, Alyssa Ray, Lauren Santos, Christopher Hess, Dawn Bowers
ObjectiveApathy, a motivational disorder, is common in Parkinson’s disease (PD) and often misdiagnosed as depression. Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with increased apathy in adolescents and adults with depression. Based on observations that serotonin may downregulate dopaminergic systems, we examined the relationship between apathy and SSRI use in individuals
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Neuropsychiatric Comorbidities and Psychotropic Medication Use in Medicare Beneficiaries With Dementia by Sex and Race J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-05-21 Kim G. Johnson, Cassie Ford, Amy G. Clark, Melissa A. Greiner, Jay B. Lusk, Cody Perry, Richard O’Brien, Emily C. O’Brien
BackgroundNeuropsychiatric symptoms affect the majority of dementia patients. Past studies report high rates of potentially inappropriate prescribing of psychotropic medications in this population. We investigate differences in neuropsychiatric diagnoses and psychotropic medication prescribing in a local US cohort by sex and race.MethodsWe utilize Medicare claims and prescription fill records in a
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Etiological Subclassification of Stroke in Older People ≥80 Years Compared to Younger People: A Systematic Review and Meta-Analysis J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-05-18 Johan Sanner, Jakob O. Ström, Mia von Euler, Bente Thommessen, Brynjar Fure
BackgroundDue to the rapid growth of the world´s oldest population, the number of older persons with stroke is expected to rise. Knowledge of stroke etiology is essential to offer personalized and equal health care across age groups. The present systematic review aimed to investigate the prevalence of etiological subtypes of ischemic and hemorrhagic stroke in older compared to younger people.MethodsMEDLINE
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Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-05-17 Amish Gaur, Damien Gallagher, Nathan Herrmann, Jinghan Jenny Chen, Susan Marzolini, Paul Oh, Yutaka Amemiya, Arun Seth, Alex Kiss, Krista L. Lanctôt
BackgroundNeurofilament Light Chain (NfL) is a biomarker of axonal injury elevated in mild cognitive impairment (MCI) and Alzheimer’s disease dementia. Blood NfL also inversely correlates with cognitive performance in those conditions. However, few studies have assessed NfL as a biomarker of global cognition in individuals demonstrating mild cognitive deficits who are at risk for vascular-related cognitive
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Sex Differences in Delirium after Coronary Artery Bypass Graft Surgery and Perioperative Neuropsychiatric Conditions: A Secondary Analysis of a Cohort Study J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-04-12 Mark A. Oldham, Bennett Kukla, Patrick Walsh, Hochang B Lee
BackgroundBiological sex influences the risk of depression and cognitive impairment, but its role in relation to postoperative delirium is unclear. This analysis investigates sex differences in delirium risk after coronary artery bypass graft (CABG) surgery and sex-related differences in relation to affective and cognitive symptoms.MethodsThis is a secondary analysis of the Neuropsychiatric Outcomes
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Findings from the Promoting Independence in Dementia App (PRIDE-app) Study a Reach, Effectiveness, Adoption, Implementation, and Maintenance Framework Discussion J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-04-10 Abigail Rebecca Lee, Orii McDermott, Martin Orrell
IntroductionSelf-management is pivotal in helping people with their independence and in managing their health conditions more effectively. The PRIDE-app is a novel online intervention, providing support and information for people living with dementia and their families, aimed at increasing self-management and improving quality of life. Knowledge generated will help inform future developments to the
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APOE Genotype Disclosure Influences Decisions About Future Planning but not Adoption of Healthy Lifestyle Changes in Cognitively Unimpaired Individuals J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-03-09 Dominique L. Popescu, Athene K. Lee, Edmund Arthur, Louisa I. Thompson, Jessica Alber
BackgroundStudies have shown apolipoprotein E (APOE) genotype disclosure to be safe and well-tolerated in cognitively unimpaired (CU) older adults. This study aimed to examine the effect of the disclosure process on decisions about future directives and health behaviors in community-dwelling CU older adults from the Butler Alzheimer’s Prevention Registry (BAPR).MethodsCU APOE E4 non-carriers (n = 106)
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Physical Exercise for Treating the Anxiety and Depression Symptoms of Parkinson’s Disease: Systematic Review and Meta-Analysis J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-03-06 Valton Costa, José Mario Prati, Alice de Oliveira Barreto Suassuna, Thanielle Souza Silva Brito, Thalita Frigo da Rocha, Anna Carolyna Gianlorenço
BackgroundDepression and anxiety are non-motor symptoms of Parkinson’s disease (PD). Physical exercise is a promising approach to reducing neuropsychological burden. We aimed to comprehensively synthesize evidence regarding the use of exercise for treating depression and anxiety symptoms in PD.MethodsSystematic review and meta-analysis following PRISMA recommendations. Searches on PubMed, Cochrane
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Forecasted Dementia Prevalence in Portugal (2020-2080) J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-03-04 Sara Alves, Natália Duarte, Barbara Gomes
Dementia is a global public health challenge, and its impact on Portugal is yet unclear. This study forecasts dementia prevalence in Portugal until 2080. Using the Gonçalves-Pereira et al (2021) method, we estimated dementia cases among older adults (≥65 years) in the community. Applying age-sex specific prevalence rates of the Gonçalves-Pereira study to population projections for Portugal between
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Validity and Reliability of the Turkish Version of Mild Behavioral Impairment Checklist in Patients With Cognitive Impairment. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-02-20 İmge Coskun Pektas,Cansu Budak,Kadir Pektas,Cansun Sahin Cam,Rumeysa Tasdelen,Can Ilgin,Serhat Ergun
BACKGROUND AND OBJECTIVE The Mild Behavioral Impairment-Checklist (MBI-C) was developed to detect and standardize neuropsychiatric symptoms. The objective of this study was to evaluate the Turkish adaptation, validity, and reliability of the MBI-C. METHODS The sample of our study consisted of 80 patients with cognitive impairment and a control group with 113 participants whose cognitive impairment
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A Systematic Review of Dementia Research Priorities J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-02-10 Manonita Ghosh, Pelden Chejor, Melanie Baker, Davina Porock
IntroductionPatient involvement is a critical component of dementia research priority-setting exercises to ensure that research benefits are relevant and acceptable to those who need the most. This systematic review synthesises research priorities and preferences identified by people living with dementia and their caregivers.MethodsGuided by Joanna Briggs Institute methodology, and Preferred Reporting
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Multiple Early Biomarkers to Predict Cognitive Decline in Dementia-Free Older Adults J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-02-09 Juan Li, Zhiying Jiang, Shengjie Duan, Xingxing Zhu
IntroductionBaseline olfactory impairment, poor performance on cognitive test, and medial temporal lobe atrophy are considered biomarkers for predicting future cognitive decline in dementia-free older adults. However, the combined effect of these predictors has not been fully investigated.MethodsA group of 110 participants without dementia were continuously recruited into this study, and underwent
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The Starkstein Apathy Scale-Italian Version: An Update J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-01-18 Ciro R. Ilardi, Maria Sannino, Giovanni Federico, Mara A. Cirillo, Carlo Cavaliere, Alessandro Iavarone, Elisabetta Garofalo
Apathy can manifest in various neuropsychiatric conditions, as well as in individuals who experience significant stressful life events or suffer from underlying internal medical conditions. The Starkstein Apathy Scale (SAS) is recognized as a reliable screening tool, besides being endorsed by the International Parkinson and Movement Disorder Society to assess apathy in patients with Parkinson’s disease
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The Care Needs of Patients With Cognitive Impairment in Late-Stage Parkinson’s Disease J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-01-17 Jennifer S. Pigott, Bastiaan R. Bloem, Stefan Lorenzl, Wassilios G. Meissner, Per Odin, Joaquim J. Ferreira, Richard Dodel, Anette Schrag
BackgroundCognitive impairment is common in Parkinson’s disease (PD), but care needs and resource use for those with significant cognitive impairment are not well established.Methods675 participants with PD from the international Care of Late-Stage Parkinsonism (CLaSP) study were grouped into those without (n = 333, 49%) and with cognitive impairment (MMSE < 24/30 or diagnosis of dementia or Mild Cognitive
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Quantitative EEG in the Differential Diagnosis of Dementia Subtypes J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2024-01-13 Yeşim Olğun, Cana Aksoy Poyraz, Melda Bozluolçay, Burç Çağrı Poyraz
ObjectiveMost neurodegenerative dementias present with substantial overlap in clinical features. Therefore, differential diagnosis is often a challenging task necessitating costly and sometimes invasive diagnostic procedures. A promising, non-invasive and cost-effective method is the widely available electroencephalography (EEG).MethodsTwenty-three subjects with Alzheimer’s disease (AD), 28 subjects
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Reward and Punishment Learning as Predictors of Cognitive Behavioral Therapy Response in Parkinson's Disease Comorbid with Clinical Depression. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-12-29 Rokas Perskaudas,Catherine E Myers,Alejandro Interian,Mark A Gluck,Mohammad M Herzallah,Allan Baum,Roseanne D Dobkin
Depression is highly comorbid among individuals with Parkinson's Disease (PD), who often experience unique challenges to accessing and benefitting from empirically supported interventions like Cognitive Behavioral Therapy (CBT). Given the role of reward processing in both depression and PD, this study analyzed a subset (N = 25) of participants who participated in a pilot telemedicine intervention of
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Prevalence of and Factors Associated with Hypersexuality in Patients with Dementia: A Retrospective Cross-Sectional Study. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-12-29 Saulo Queiroz Borges,Einstein Francisco Camargos
INTRODUCTION The psychological and behavioral symptoms of dementia are frequently observed in clinical practice, and those related to sexuality are particularly challenging. However, few studies have evaluated the prevalence or factors associated with hypersexuality in patients with dementia. OBJECTIVES This study aims to determine the prevalence of hypersexuality in patients with dementia, describe
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The Rapid Access Memory Program for Addressing Concerns of Incipient Dementia in Academic Primary Care Settings. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-12-29 Travis H Turner,Emmi P Scott,Katherine Barlis,Federico Rodriguez-Porcel,Andrea C Sartori,Jane Joseph
BACKGROUND Expedient diagnosis of incipient dementia is often hindered by time constraints in primary care visits, shortage of dementia specialists, and extended waitlists for comprehensive neuropsychological evaluations. METHODS We developed the Rapid Access Memory Program (RAMP) to improve access of neuropsychological services for older adults presenting to our institutional primary care clinics
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The Effects of Cognitive Ability, Mental Health, and Self-Quarantining on Functional Ability of Older Adults During the COVID-19 Pandemic: Results From the Canadian Longitudinal Study on Aging. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-12-20 Madeline A Gregory,Morgan J Schaeffer,Jennifer T H Reeves,Lauren E Griffith,Christina Wolfson,Nicole E Basta,Jacqueline M McMillan,Susan Kirkland,Parminder Raina,Theone S E Paterson,
OBJECTIVES Determine whether levels of anxiety and depression, cognitive ability, and self-quarantining during and prior to the pandemic predict decreases in perceived functional ability. DESIGN AND SETTING Longitudinal data collected from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Questionnaire Study (2020) and core CLSA study (Follow-Up 1; 2014-2018). PARTICIPANTS 17 541 CLSA participants
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Association of Higher Mediterranean Diet Adherence With Lower Prevalence of Disability and Symptom Severity, Depression, Anxiety, Stress, Sleep Quality, Cognitive Impairment, and Physical Inactivity in Older Adults With Multiple Sclerosis. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-11-29 Christina Tryfonos,Eleni Pavlidou,Theofanis Vorvolakos,Olga Alexatou,Konstantinos Vadikolias,Maria Mentzelou,Gerasimos Tsourouflis,Aspasia Serdari,Georgios Antasouras,Sousana K Papadopoulou,Exakousti-Petroula Aggelakou,Constantinos Giaginis
A good nutritional status and healthy diets may decelerate disease disability and symptom severity and quality of life of peoples with multiple sclerosis (MS). Mediterranean diet (MD) can prevent several chronic diseases, including neurodegenerative disease. This is an observational, cross-sectional study on 279 older adults with MS, aiming to investigate the effects of MD against several aspects of
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Association Between Mid-arm Muscle Circumference and Cognitive Function: A Longitudinal Study of Chinese Adults. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-11-22 Hillary B Spangler,David H Lynch,Annie Green Howard,Hsiao-Chuan Tien,Shufa Du,Bing Zhang,Huijun Wang,Penny Gordon Larsen,John A Batsis
BACKGROUND Dementia affects 55 million people worldwide and low muscle mass may be associated with cognitive decline. Mid-arm muscle circumference (MAMC) correlates with dual-energy Xray absorptiometry and bioelectrical impedance analyses, yet are not routinely available. Therefore, we examined the association between MAMC and cognitive performance in older adults. METHODS We included community-dwelling
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Impact of Care-Recipient Relationship Type on Quality of Life in Community-Dwelling Older Adults With Dementia Over Time. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-11-11 Aiping Lai,Lauren E Griffith,Ayse Kuspinar,Jenna-Smith Turchyn,Julie Richardson
INTRODUCTION Maintaining quality of life (QoL) has been identified as the primary goal of care services for person living with dementia (PLWD). METHODS A secondary analysis was conducted on five rounds of the National Health and Aging Trends Study (NHATS) over 4 years. A generalized estimating equation (GEE) was used to examine the prediction of relationship type on older adults' QoL through four domains:
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Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-11-11 Henry D Heisey,Clifford Qualls,Dennis T Villareal,Martha Belen Segoviano-Escobar,Maria Liza Duremdes Nava,Jennifer R Gatchel,Mark E Kunik
OBJECTIVES To test the hypothesis that depressive symptoms vary with high-sensitivity C-reactive protein (hs-CRP), among older adults with obesity. METHODS This was a cross-sectional, secondary analysis of baseline data from two related lifestyle intervention trials. The study sample comprises 148 consecutively recruited, community-dwelling older adults (age >=65 years) without severe psychiatric illness
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A First Exploration: Can Eye Movement Desensitization and Reprocessing Improve Cognition in Older Adults With Posttraumatic Stress Disorder? J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-10-23 Ellen M J Gielkens,Gina Rossi,Sebastiaan P J van Alphen,Sjacko Sobczak
OBJECTIVES In older adults, PTSD is associated with decreased verbal learning and executive dysfunction. Therefore, feasibility of EMDR-treatment to improve cognitive performance in older adults with PTSD was examined. Additionally, we investigated pre-treatment correlation with often co-occurring risk factors for cognitive decline (sleep problems, depressive disorder, physical inactivity, childhood
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The Relationship Between Apathy and Cognitive Impairment Among Hispanic/Latin Americans: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses Systematic Review. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-10-19 Joshua M Garcia,Jai Sehgal,Jennifer L Thompson,Steven Paul Woods,Luis D Medina
OBJECTIVES The primary aim was to evaluate apathy assessment measures in relation to cognitive impairment among Hispanic/Latin Americans. METHODS A systematic review on the relationship between apathy and cognitive impairment among Hispanic/Latin Americans across normal aging and neurocognitive disorders was conducted according to preferred reporting items for systematic reviews and meta-analyses (PRISMA)
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A Novel Approach to Monitoring Cognitive Adverse Events for Interventional Studies Involving Advanced Dementia Patients: Insights From the Electroconvulsive Therapy for Agitation in Dementia Study. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-10-17 Soohyun Park,Brent P Forester,Maria I Lapid,David G Harper,Adriana P Hermida,Sharon K Inouye,Shawn M McClintock,Louis Nykamp,Georgios Petrides,Eva M Schmitt,Stephen J Seiner,Martina Mueller,Regan E Patrick
OBJECTIVE To develop an individualized method for detecting cognitive adverse events (CAEs) in the context of an ongoing trial of electroconvulsive therapy for refractory agitation and aggression for advanced dementia (ECT-AD study). METHODS Literature search aimed at identifying (a) cognitive measures appropriate for patients with advanced dementia, (b) functional scales to use as a proxy for cognitive
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The Relationship Between Autonomic Dysfunction and Mood Symptoms in De Novo Parkinson's Disease Patients Over Time. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-10-13 Adrianna M Ratajska,Connor B Etheridge,Francesca V Lopez,Lauren E Kenney,Katie Rodriguez,Rachel N Schade,Joshua Gertler,Dawn Bowers
BACKGROUND Autonomic dysfunction is prevalent in Parkinson's disease (PD) and can worsen quality of life. We examined: (a) whether specific autonomic symptoms were more strongly associated with anxiety or depression in PD and (b) whether overall autonomic dysfunction predicted mood trajectories over a 5-year period. METHODS Newly diagnosed individuals with PD (N = 414) from the Parkinson's Progression
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Depressive Symptoms Moderate the Association Between Functional Level at Admission to Intensive Post-Stroke Rehabilitation and Effectiveness of the Intervention. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-10-12 Salvatore Mazzeo,Silvia Pancani,Alessandro Sodero,Chiara Castagnoli,Angela Maria Politi,Monica Barnabè,Francesca Ciullini,Marco Baccini,Antonello Grippo,Bahia Hakiki,Claudio Macchi,Francesca Cecchi
INTRODUCTION Previous studies showed that depression acts as an independent factor in functional recovery after stroke. In a prospective cohort of patients admitted to intensive inpatient rehabilitation after a stroke, we aimed to test depression as a moderator of the relationship between the functional level at admission and the effectiveness of rehabilitation at discharge. METHODS All patients admitted
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Antidementia Medication Use in Nursing Home Residents. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-09-16 Brian R Ott,Carl Hollins,Jennifer Tjia,Jonggyu Baek,Qiaoxi Chen,Kate L Lapane,Matthew Alcusky
BACKGROUND Antidementia medication can provide symptomatic improvements in patients with Alzheimer's disease, but there is a lack of consensus guidance on when to start and stop treatment in the nursing home setting. METHODS We describe utilization patterns of cholinesterase inhibitors (ChEI) and memantine for 3,50,197 newly admitted NH residents with dementia between 2011 and 2018. RESULTS Overall
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Effects of Sport Stacking on Cognition in Patients With Mild Alzheimer's Disease and MCI: Preliminary Findings of Randomized Controlled Trial. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-09-05 Ziying Yang,Jun Yang,Doris S F Yu,Dunxiu Liu,Fu Ding
OBJECTIVE This mixed-method pilot study aims to investigate the feasibility and preliminary effects of sport stacking on cognitive function in individuals with mild Alzheimer's disease (AD) and those with mild cognitive impairment (MCI). METHODS Twenty-four community-dwelling subjects with confirmed mild AD or MCI were evenly randomly assigned to either the 12-week sport stacking intervention group
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Does the Etiology, Phenomenology and Motor Subtype of Delirium Differ When It Occurs in Patients With An Underlying Dementia?: A Multi-Site, International Study. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-11 Kevin Glynn,Frank McKenna,Kevin Lally,Sandeep Grover,Subho Chakrabarti,Surendra K Mattoo,Ajita Avasthi,Akhilesh Sharma,Dimitrios Adamis,Fahad Awan,Colum P Dunne,John McFarland,Faiza Jabbar,Henry O'Connell,Maeve Leonard,David J Meagher
OBJECTIVES To compare the etiology, phenomenology and motor subtype of delirium in patients with and without an underlying dementia. METHODS A combined dataset (n = 992) was collated from two databases of older adults (>65 years) from liaison psychiatry and palliative care populations in Ireland and India. Phenomenology and severity of delirium were analysed using the Delirium Symptom Rating Scale
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Burden and Depression among Empirically-Derived Subgroups of Family Caregivers for Individuals With Dementia. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-08 Nina Ahmad,Zachary J Kunicki,Ellen Tambor,Gary Epstein-Lubow,Geoffrey Tremont
Dementia caregiving experiences are not universal and different factors may influence the risk for burden and depression. This study examined factors such as the relationship with the care recipient, severity of dementia, and relationship satisfaction to uncover different types of caregiver burden profiles using baseline assessment for a telephone-based intervention study for dementia caregivers. Participants
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Caregiver Burden in Parkinson Disease: A Scoping Review of the Literature from 2017-2022. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-08 Whitley W Aamodt,Benzi M Kluger,Miray Mirham,Anna Job,Samantha E Lettenberger,Philip E Mosley,Sandhya Seshadri
Caregiver burden is a term that refers to the adverse effect of caregiving on the physical, emotional, social, spiritual, and financial well-being of the caregiver. Caregiver burden is associated with providing care to an individual with a chronic illness or disability, and the unique symptoms of Parkinson disease (PD) can amplify a patient's needs and reliance on others, leading to adverse outcomes
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Language Impairment in Vascular Dementia: A Clinical Review. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-08 Joël Macoir
Vascular cognitive impairment (VCI) encompasses a wide range of conditions, including cognitive impairment associated with stroke or vascular brain injury, mild vascular cognitive impairment, and vascular dementia (VD). Knowledge of language impairment associated with VD is far less extensive than that of Alzheimer's disease. Although not prevalent in VD, impairment in language skills has been reported
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Atypical Neuropsychiatric Presentation of FTD-ALS Caused by a Pathogenic Repeat Expansion in C9orf72: A Case Report. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-07 Marissa A LeBlanc,Amy Gough,Andrea L Rideout,Sarah Dyack,Kathleen Singh,Meagan MacNeil
The case report describes the presentation of a 42-year-old male ultimately diagnosed with FTD-ALS caused by a genetic mutation, who initially presented with atypical psychiatric symptoms. Given that the initial clinical manifestations of FTD-ALS can be quite variable, the diagnosis is often challenging; the case report aims to highlight several key considerations in the diagnostic assessment, including
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Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-05 Allen P F Chen,Zahinoor Ismail,Frank D Mann,Evelyn J Bromet,Sean A P Clouston,Benjamin J Luft
Objective: World Trade Center (WTC) responders are susceptible to both cognitive and neuropsychiatric impairments, particularly chronic posttraumatic stress disorder. The present study examined self-reported behavioral impairments in a sample of 732 WTC responders, 199 of whom were determined to have high risk of WTC-related cortical atrophy by an artificial neural network. Results: We found that responders
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Minor Phenomena in Parkinson's Disease-Prevalence, Associations, and Risk of Developing Psychosis. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-05 Ruth B Schneider,Peggy Auinger,Roseanne D Dobkin,Kelly A Mills,Catherine V Kulick-Soper,Taylor L Myers,Monica Korell,Gregory M Pontone,Melissa J Nirenberg
BACKGROUND Minor phenomena, including passage phenomena, feeling of presence, and illusions, are common and may represent a prodromal form of psychosis in Parkinson's disease (PD). We examined the prevalence and clinical correlates of minor phenomena, and their potential role as a risk factor for PD psychosis. METHODS A novel questionnaire, the Psychosis and Mild Perceptual Disturbances Questionnaire
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Predicting Caregiver Communications in a Geriatric Clinic. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-04 John T Martin,Jason R Anderson,Kimberly R Chapman,Natalie Kayani,Jennifer Drost,Mary Beth Spitznagel
The current study evaluated the use of a machine learning model to determine benefit of medical record variables in predicting geriatric clinic communication requirements. Patient behavioral symptoms and global cognition, medical information, and caregiver intake assessments were extracted from 557 patient records. Two independent raters reviewed the subsequent 12 months for documented (1) incoming
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Emotion Regulation in Dementia Caregiving: The Role of Neuropsychiatric Symptoms and Attachment Orientation. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-04 Tânia Brandão,Rute Brites,João Hipólito,Odete Nunes,Catarina Tomé Pires
Family caregivers are usually the main source of support for persons living with dementia, being exposed to a loved one's suffering, which can lead to experiencing strong and negative emotions. This study aimed to identify factors capable of explaining individual differences in the way caregivers regulate their emotions. This cross-sectional study included 78 informal caregivers (M = 64.84 years; SD
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Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-08-03 Ayumi Tachibana,Jun-Ichi Iga,Yasuko Tatewaki,Benjamin Thyreau,Hongkun Chen,Tomoki Ozaki,Taku Yoshida,Yuta Yoshino,Hideaki Shimizu,Takaaki Mori,Yoshihiko Furuta,Mao Shibata,Tomoyuki Ohara,Jun Hata,Yasuyuki Taki,Shigeyuki Nakaji,Tetsuya Maeda,Kenjiro Ono,Masaru Mimura,Kenji Nakashima,Minoru Takebayashi,Toshiharu Ninomiya,Shu-Ichi Ueno,
BACKGROUND Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes
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Virtual Group Music Therapy for Apathy in Parkinson's Disease: A Pilot Study. J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-05-18 Deepal Shah-Zamora,Sharlet Anderson,Brandon Barton,Jori E Fleisher
OBJECTIVE To evaluate the effect of virtual group music therapy on apathy in people with Parkinson's disease (PD). INTRODUCTION Apathy affects 40% of people with PD, lacks effective therapies, and independently predicts poorer quality of life and greater caregiver burden. Music therapy is the clinical application of music to address a person's physical or emotional needs and is effective in treating
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Assessment of Personality Disorders in Older Adults. A Practice Guide J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-05-12 Sebastiaan PJ van Alphen, Sanne van der Werff, Erlene Rosowsky, Daniel L Segal, Gina Rossi
Assessment of personality disorders (PDs) in older adults is a nuanced trade of its own. The aim of this practice guide is to illustrate gerontological assessment challenges using 3 case vignettes....
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Geriatric Psychiatrists’ Perspectives on Palliative Care: Results From A National Survey J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-05-09 Hana Elhassan, Gregg A. Robbins-Welty, Jerad Moxley, M. Carrington Reid, Daniel Shalev
ObjectivesOlder adults with psychiatric illnesses often have medical comorbidities that require symptom management and impact prognosis. Geriatric psychiatrists are uniquely positioned to meet the ...
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Facial Expression Recognition of Emotional Situations in Mild and Moderate Alzheimer’s Disease J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-05-09 Michelle Brandt, Felipe de Oliveira Silva, José Pedro Simões Neto, Maria Alice Tourinho Baptista, Tatiana Belfort, Isabel Barbeito Lacerda, Marcia Cristina Nascimento Dourado
Background: Recognizing emotional situations may be impaired in people with Alzheimer’s disease (AD). Purpose: We examined differences in the comprehension of an emotional situation in healthy olde...
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Baseline Differences in Driving Frequency as a Predictor of Cognitive Decline and Alzheimer’s Disease J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-05-06 Luke R. Miller, Christopher Reed, Ross Divers, Matthew Calamia
ObjectiveTo extend prior research by examining daily driving frequency as a predictor of cognitive decline and later diagnosis of Alzheimer’s disease.Methods1,426 older adults completed batteries o...
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Support Needs in Carers of People With Parkinson’s From Early to Later Stages: A Qualitative Study With 36 Carers in 11 European Countries J. Geriatr. Psychiatry Neurol. (IF 2.9) Pub Date : 2023-04-20 Rowena K. Merritt, Sarah Hotham, Anette Schrag
BackgroundParkinson’s Disease (PD) is associated with considerable carer burden, but there has been little qualitative research on the support needs of carers of People with Parkinson’s (PwP).Metho...