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Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging Biogerontology (IF 4.4) Pub Date : 2024-09-19 Ram Prajit, Rasa Saenno, Kornrawee Suwannakot, Soraya Kaewngam, Tanaporn Anosri, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
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Identification of a new human senescent skin cell marker ribonucleoside-diphosphate reductase subunit M2 B Biogerontology (IF 4.4) Pub Date : 2024-09-11 Kento Takaya, Kazuo Kishi
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The impact of social partners: investigating mixed-strain housing effects on aging in female mice Biogerontology (IF 4.4) Pub Date : 2024-09-11 Chih-Lin Lee, Yu-Chiao Lin, Tsung-Han Kuo
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The opposite aging effect to single cell transcriptome profile among cell subsets Biogerontology (IF 4.4) Pub Date : 2024-09-11 Daigo Okada
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Directionality theory and mortality patterns across the primate lineage Biogerontology (IF 4.4) Pub Date : 2024-09-06 Lloyd A. Demetrius, Anand Sahasranaman, Martin Ziehe
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The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age Biogerontology (IF 4.4) Pub Date : 2024-09-02 Farid Abou Abdallah, Christine Abdel Massih, Charbel Attieh, Alain Chebly
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Immunoinformatic-based drug design utilizing hesperetin to target CISD2 activation for liver aging in humans Biogerontology (IF 4.4) Pub Date : 2024-08-28 Saad Ilyas Baig, Maria Naseer, Abdur-Rehman Munir, Yasir Ali, Muhammad Asif Razzaq
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Mitochondria: fundamental characteristics, challenges, and impact on aging Biogerontology (IF 4.4) Pub Date : 2024-08-28 Runyu Liang, Luwen Zhu, Yongyin Huang, Jia Chen, Qiang Tang
As one of the most vital organelles within biological cells, mitochondria hold an irreplaceable status and play crucial roles in various diseases. Research and therapies targeting mitochondria have achieved significant progress in numerous conditions. Throughout an organism’s lifespan, mitochondrial dynamics persist continuously, and due to their inherent characteristics and various external factors
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Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders Biogerontology (IF 4.4) Pub Date : 2024-08-23 Ishika Singh, Shashi Anand, Deepashree J. Gowda, Amitha Kamath, Abhishek Kumar Singh
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The role of phagocytic cells in aging: insights from vertebrate and invertebrate models Biogerontology (IF 4.4) Pub Date : 2024-08-21 Brecht Driesschaert, Lucas Mergan, Cristiano Lucci, Caroline Simon, Dulce Santos, Lies De Groef, Liesbet Temmerman
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Oxidative stress-induced gene expression changes in prostate epithelial cells in vitro reveal a robust signature of normal prostatic senescence and aging Biogerontology (IF 4.4) Pub Date : 2024-08-20 Samael Olascoaga, Jorge I. Castañeda-Sánchez, Mina Königsberg, Humberto Gutierrez, Norma Edith López-Diazguerrero
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Dietary nitrate maintains intestinal epithelia homeostasis in aged mice Biogerontology (IF 4.4) Pub Date : 2024-08-20 Xue Wang, Huan Liu, Mingwei Yue, Jinsong Wang, Chunmei Zhang, Lizheng Qin, Songlin Wang, Lei Hu
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The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection Biogerontology (IF 4.4) Pub Date : 2024-08-20 Elroei David, Marina Wolfson, Khachik K. Muradian, Vadim E. Fraifeld
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Influence of α-lipoic acid on longevity and stress resistance in Drosophila melanogaster fed with a high-fat diet Biogerontology (IF 4.4) Pub Date : 2024-07-24 Debarati Chattopadhyay, Susan Mary Philip, Grace Prabhakar, Madappa Machamada Bheemaiah
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The long noncoding RNA (LINC-RBE) expression in testicular cells is associated with aging of the rat Biogerontology (IF 4.4) Pub Date : 2024-07-17 Ajay Kumar Danga, Sukhleen Kour, Anita Kumari, Pramod C. Rath
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Network pharmacology-based approach to investigate the molecular targets and molecular mechanisms of Rosmarinus officinalis L. for treating aging-related disorders Biogerontology (IF 4.4) Pub Date : 2024-07-17 Amisha Bisht, Disha Tewari, Sanjay Kumar, Subhash Chandra
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Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study Biogerontology (IF 4.4) Pub Date : 2024-07-13 Virginia Boccardi, Luigi Cari, Patrizia Bastiani, Michela Scamosci, Roberta Cecchetti, Giuseppe Nocentini, Patrizia Mecocci
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The influence of sex-specific factors on biological transformations and health outcomes in aging processes Biogerontology (IF 4.4) Pub Date : 2024-07-13 Yongyin Huang, Hongyu Li, Runyu Liang, Jia Chen, Qiang Tang
The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of sex bias in organisms. Moreover, sex-specific epigenetic modifications and changes in sex hormone levels impact the development of immunity differently during embryonic development and beyond
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Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins Biogerontology (IF 4.4) Pub Date : 2024-07-06 Shaojun Wang, Hong Yang
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Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice Biogerontology (IF 4.4) Pub Date : 2024-07-06 Pynskhem Bok Swer, Babiangshisha Kharbuli, Donkupar Syiem, Ramesh Sharma
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Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases Biogerontology (IF 4.4) Pub Date : 2024-07-01 Antero Salminen
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Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast Biogerontology (IF 4.4) Pub Date : 2024-06-06 Karolina Stępień, Tuguldur Enkhbaatar, Monika Kula-Maximenko, Łukasz Jurczyk, Adrianna Skoneczna, Mateusz Mołoń
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Compensation effect of mortality is a challenge to substantial lifespan extension of humans Biogerontology (IF 4.4) Pub Date : 2024-05-29 Natalia S. Gavrilova, Leonid A. Gavrilov
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Enhancing the human health and lifespan: a targeted strategy emphasizing statins Biogerontology (IF 4.4) Pub Date : 2024-05-29 Edward Calabrese, Peter Pressman
There has been substantial research interest in finding activities/agents that slow the onset and reduce the severity of numerous age-related diseases/conditions. This assessment indicates that the most studied agent intended to promote health in human population investigations for a broad spectrum of diseases are the statins, with large-scale epidemiological studies addressing numerous health endpoints
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Inhibition of mTOR prevents glucotoxicity-mediated increase of SA-beta-gal, p16INK4a, and insulin hypersecretion, without restoring electrical features of mouse pancreatic islets Biogerontology (IF 4.4) Pub Date : 2024-05-15 Tereso J. Guzmán, Nina Klöpper, Carmen M. Gurrola-Díaz, Martina Düfer
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Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice Biogerontology (IF 4.4) Pub Date : 2024-05-15 Irene Martínez de Toda, Judith Félix, Estefanía Díaz-Del Cerro, Mónica De la Fuente
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Geroscience: just another name or is there more to it? Biogerontology (IF 4.4) Pub Date : 2024-05-15 Simon Okholm
The widespread use of the name ‘geroscience’ in the science of aging is sometimes met with a wary attitude by biogerontologists other than its inventors. Here, we provide an overview of its origin and evolution to assess what exactly it is and to discuss its theoretical and biological relationship to earlier movements of anti-aging medicine and biogerontology more generally. Geroscience posits that
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Analysis of the relationship between age-related erythrocyte dysfunction and fatigue Biogerontology (IF 4.4) Pub Date : 2024-05-07 Yuichiro Ogata, Takaaki Yamada, Masahiro Fujimura, Toshio Igarashi, Seiji Hasegawa
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Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo Biogerontology (IF 4.4) Pub Date : 2024-04-15 Kento Takaya, Kazuo Kishi
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RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells Biogerontology (IF 4.4) Pub Date : 2024-04-15 Manisekaran Hemagirri, Yeng Chen, Subash C. B. Gopinath, Mohd Adnan, Mitesh Patel, Sreenivasan Sasidharan
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Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats Biogerontology (IF 4.4) Pub Date : 2024-04-15 Berrin Papila, Ayla Karimova, Ilhan Onaran
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Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway Biogerontology (IF 4.4) Pub Date : 2024-04-09 Yangmin Xia, Hao Zhang, Xiangyi Wu, Ye Xu, Qian Tan
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Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet Biogerontology (IF 4.4) Pub Date : 2024-04-06 Qianhua Yuan, Mengliu Luo, Yutong Xie, Wanhan Song, Ya Wang, Dazhang Deng, Shuyan Chen, Honghui Guo
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Telomeres and aging: on and off the planet! Biogerontology (IF 4.4) Pub Date : 2024-04-06 Christopher E. Mason, Maria A. Sierra, Henry J. Feng, Susan M. Bailey
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Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect Biogerontology (IF 4.4) Pub Date : 2024-03-28 Hye-Yeon Lee, Ji-Hyeon Lee, Jisun Baek, Kyung A. Cho, Kyung-Jin Min
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The potential use of nanozyme in aging and age‐related diseases Biogerontology (IF 4.4) Pub Date : 2024-03-11 Amirsasan Gorgzadeh, Paria Arab Amiri, Saman Yasamineh, Basim Kareem Naser, Khairia abdulrahman abdulallah
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Telomeres in health and longevity: special issue in memory of Alexey Olovnikov Biogerontology (IF 4.4) Pub Date : 2024-03-05 Ivan A. Olovnikov
In this special issue we commemorate theoretical biologist Alexey Olovnikov (1936–2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging
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A comprehensive model for the biochemistry of ageing, senescence and longevity Biogerontology (IF 4.4) Pub Date : 2024-03-05 Hiskias Gerrit Keizer, R. Brands, Ronald Sake Oosting, Willem Seinen
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Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging Biogerontology (IF 4.4) Pub Date : 2024-03-04 Kento Takaya, Kazuo Kishi
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The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway Biogerontology (IF 4.4) Pub Date : 2024-02-26 Qixuan Huang, Jie Chen, Siqi Liao, Jiangchuan Long, Ronghua Fang, Yusen He, Peiyun Chen, Dongfang Liu
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Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat Biogerontology (IF 4.4) Pub Date : 2024-02-14 Ajay Kumar Danga, Sukhleen Kour, Anita Kumari, Pramod C. Rath
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Renal aging and mitochondrial quality control Biogerontology (IF 4.4) Pub Date : 2024-02-13 Xiuli Guo, Jiao Wang, Yinjie Wu, Xinwang Zhu, Li Xu
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A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging Biogerontology (IF 4.4) Pub Date : 2024-02-04 Gustavo Borges, Yahya Benslimane, Lea Harrington
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Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems Biogerontology (IF 4.4) Pub Date : 2024-01-22 Pat Monaghan
This perspectives paper considers the value of studying telomere biology outside of a biomedical context. I provide illustrative examples of the kinds of questions that evolutionary ecologists have addressed in studies of telomere dynamics in non-model species, primarily metazoan animals, and what this can contribute to our understanding of their evolution, life histories and health. I also discuss
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Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome Biogerontology (IF 4.4) Pub Date : 2024-01-19 Bhawna Diwan, Rahul Yadav, Rohit Goyal, Rohit Sharma
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Seven knowledge gaps in modern biogerontology Biogerontology (IF 4.4) Pub Date : 2024-01-11 Suresh I. S. Rattan
About a year ago, members of the editorial board of Biogerontology were requested to respond to a query by the editor-in-chief of the journal as to what one question within their field of ageing research still needs to be asked and answered. This editorial is inspired by the wide range and variety of questions, ideas, comments and suggestions received in response to that query. The seven knowledge
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Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice Biogerontology (IF 4.4) Pub Date : 2024-01-06 Ting-Rui Zhang, Chun-Hsien Chiang, Tzu-Chieh Hsu, Chih-Yun Wang, Ching-Yi Chen
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Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies Biogerontology (IF 4.4) Pub Date : 2023-12-27 Xiao-Ming Wang, Lu Fan, Chen-Chen Meng, Yun-Jiao Wang, Li-E Deng, Zhuo Yuan, Jun-Ping Zhang, Yan-Yang Li, Shi-Chao Lv
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Telomeres, cellular senescence, and aging: past and future Biogerontology (IF 4.4) Pub Date : 2023-12-27 Madeline Eppard, João F. Passos, Stella Victorelli
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Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex Biogerontology (IF 4.4) Pub Date : 2023-12-27 Denis Golubev, Elena Platonova, Nadezhda Zemskaya, Oksana Shevchenko, Mikhail Shaposhnikov, Polina Nekrasova, Sergey Patov, Umida Ibragimova, Nikita Valuisky, Alexander Borisov, Xenia Zhukova, Svetlana Sorokina, Roman Litvinov, Alexey Moskalev
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Application potential of senolytics in clinical treatment Biogerontology (IF 4.4) Pub Date : 2023-12-18 Tiantian Li, Shiyuan Li, Kefeng Ma, Jinming Kong
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Telomere length and cancer risk: finding Goldilocks Biogerontology (IF 4.4) Pub Date : 2023-12-18 Sharon A. Savage
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How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process? Biogerontology (IF 4.4) Pub Date : 2023-12-08 Malu Cristina de Araújo Montoro Lima, Matheus Felipe Zazula, Luiz Fernando Martins, Stephanie Rubiane Carvalhal, Ana Tereza Bittencourt Guimarães, Luiz Claudio Fernandes, Katya Naliwaiko
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An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law Biogerontology (IF 4.4) Pub Date : 2023-11-25 A. Golubev
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Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes Biogerontology (IF 4.4) Pub Date : 2023-11-21 Jasmine Harley, Munirah Mohamad Santosa, Chong Yi Ng, Oleg V. Grinchuk, Jin-Hui Hor, Yajing Liang, Valerie Jingwen Lim, Wee Wei Tee, Derrick Sek Tong Ong, Shi-Yan Ng
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Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks Biogerontology (IF 4.4) Pub Date : 2023-11-16 Elena Sandalova, Andrea B. Maier
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Chromosome ends and the theory of marginotomy: implications for reproduction Biogerontology (IF 4.4) Pub Date : 2023-11-09 Isabel Córdova-Oriz, Alba M. Polonio, Isabel Cuadrado-Torroglosa, Lucía Chico-Sordo, Marta Medrano, Juan A. García-Velasco, Elisa Varela
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AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration Biogerontology (IF 4.4) Pub Date : 2023-11-02 Antero Salminen
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T-cell lymphocytes’ aging clock: telomeres, telomerase and aging Biogerontology (IF 4.4) Pub Date : 2023-11-02 Alain Chebly, Charbel Khalil, Alexandra Kuzyk, Marie Beylot-Barry, Edith Chevret