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The potential use of nanozyme in aging and age‐related diseases Biogerontology (IF 4.5) Pub Date : 2024-03-11 Amirsasan Gorgzadeh, Paria Arab Amiri, Saman Yasamineh, Basim Kareem Naser, Khairia abdulrahman abdulallah
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Telomeres in health and longevity: special issue in memory of Alexey Olovnikov Biogerontology (IF 4.5) Pub Date : 2024-03-05 Ivan A. Olovnikov
In this special issue we commemorate theoretical biologist Alexey Olovnikov (1936–2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging
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A comprehensive model for the biochemistry of ageing, senescence and longevity Biogerontology (IF 4.5) Pub Date : 2024-03-05
Abstract Various models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune
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Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging Biogerontology (IF 4.5) Pub Date : 2024-03-04 Kento Takaya, Kazuo Kishi
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The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway Biogerontology (IF 4.5) Pub Date : 2024-02-26
Abstact With advancing age, the incidence of sarcopenia increases, eventually leading to a cascade of adverse events. However, there is currently a lack of effective pharmacological treatment for sarcopenia. Sodium-glucose co-transporter 2 inhibitor (SGLT2i) empagliflozin demonstrates anti-fibrotic capabilities in various organs. This study aims to determine whether empagliflozin can improve skeletal
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Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat Biogerontology (IF 4.5) Pub Date : 2024-02-14
Abstract Long noncoding RNAs (lncRNAs) have emerged as major regulators of gene expression, chromatin structure, epigenetic changes, post-transcriptional processing of RNAs, translation of mRNAs into proteins as well as contributing to the process of ageing. Ageing is a universal, slow, progressive change in almost all physiological processes of organisms after attaining reproductive maturity and often
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Renal aging and mitochondrial quality control Biogerontology (IF 4.5) Pub Date : 2024-02-13 Xiuli Guo, Jiao Wang, Yinjie Wu, Xinwang Zhu, Li Xu
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A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging Biogerontology (IF 4.5) Pub Date : 2024-02-04 Gustavo Borges, Yahya Benslimane, Lea Harrington
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Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems Biogerontology (IF 4.5) Pub Date : 2024-01-22
Abstract This perspectives paper considers the value of studying telomere biology outside of a biomedical context. I provide illustrative examples of the kinds of questions that evolutionary ecologists have addressed in studies of telomere dynamics in non-model species, primarily metazoan animals, and what this can contribute to our understanding of their evolution, life histories and health. I also
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Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome Biogerontology (IF 4.5) Pub Date : 2024-01-19 Bhawna Diwan, Rahul Yadav, Rohit Goyal, Rohit Sharma
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Seven knowledge gaps in modern biogerontology Biogerontology (IF 4.5) Pub Date : 2024-01-11 Suresh I. S. Rattan
About a year ago, members of the editorial board of Biogerontology were requested to respond to a query by the editor-in-chief of the journal as to what one question within their field of ageing research still needs to be asked and answered. This editorial is inspired by the wide range and variety of questions, ideas, comments and suggestions received in response to that query. The seven knowledge
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Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice Biogerontology (IF 4.5) Pub Date : 2024-01-06 Ting-Rui Zhang, Chun-Hsien Chiang, Tzu-Chieh Hsu, Chih-Yun Wang, Ching-Yi Chen
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Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies Biogerontology (IF 4.5) Pub Date : 2023-12-27
Abstract Frailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not
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Telomeres, cellular senescence, and aging: past and future Biogerontology (IF 4.5) Pub Date : 2023-12-27
Abstract Over half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching
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Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex Biogerontology (IF 4.5) Pub Date : 2023-12-27 Denis Golubev, Elena Platonova, Nadezhda Zemskaya, Oksana Shevchenko, Mikhail Shaposhnikov, Polina Nekrasova, Sergey Patov, Umida Ibragimova, Nikita Valuisky, Alexander Borisov, Xenia Zhukova, Svetlana Sorokina, Roman Litvinov, Alexey Moskalev
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Application potential of senolytics in clinical treatment Biogerontology (IF 4.5) Pub Date : 2023-12-18 Tiantian Li, Shiyuan Li, Kefeng Ma, Jinming Kong
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Telomere length and cancer risk: finding Goldilocks Biogerontology (IF 4.5) Pub Date : 2023-12-18 Sharon A. Savage
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How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process? Biogerontology (IF 4.5) Pub Date : 2023-12-08 Malu Cristina de Araújo Montoro Lima, Matheus Felipe Zazula, Luiz Fernando Martins, Stephanie Rubiane Carvalhal, Ana Tereza Bittencourt Guimarães, Luiz Claudio Fernandes, Katya Naliwaiko
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An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law Biogerontology (IF 4.5) Pub Date : 2023-11-25 A. Golubev
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Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes Biogerontology (IF 4.5) Pub Date : 2023-11-21 Jasmine Harley, Munirah Mohamad Santosa, Chong Yi Ng, Oleg V. Grinchuk, Jin-Hui Hor, Yajing Liang, Valerie Jingwen Lim, Wee Wei Tee, Derrick Sek Tong Ong, Shi-Yan Ng
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Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks Biogerontology (IF 4.5) Pub Date : 2023-11-16 Elena Sandalova, Andrea B. Maier
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Chromosome ends and the theory of marginotomy: implications for reproduction Biogerontology (IF 4.5) Pub Date : 2023-11-09 Isabel Córdova-Oriz, Alba M. Polonio, Isabel Cuadrado-Torroglosa, Lucía Chico-Sordo, Marta Medrano, Juan A. García-Velasco, Elisa Varela
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AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration Biogerontology (IF 4.5) Pub Date : 2023-11-02 Antero Salminen
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T-cell lymphocytes’ aging clock: telomeres, telomerase and aging Biogerontology (IF 4.5) Pub Date : 2023-11-02 Alain Chebly, Charbel Khalil, Alexandra Kuzyk, Marie Beylot-Barry, Edith Chevret
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Methods that shaped telomerase research Biogerontology (IF 4.5) Pub Date : 2023-10-31 Louise Bartle, Raymund J. Wellinger
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“Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects” as a form of hormesis: an interview with Professor Sataro Goto Biogerontology (IF 4.5) Pub Date : 2023-10-26 Zsolt Radak
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Mitochondria and telomeres: hand in glove Biogerontology (IF 4.5) Pub Date : 2023-10-21 Mélina Vaurs, Elif Beyza Dolu, Anabelle Decottignies
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Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster Biogerontology (IF 4.5) Pub Date : 2023-10-21 Elena Yushkova
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The influence of biological sex in human skeletal muscle transcriptome during ageing Biogerontology (IF 4.5) Pub Date : 2023-10-04 Xiaoyu Huang, Mao Chen, Ya Xiao, Fangyi Zhu, Liying Chen, Xiaoyu Tian, Li Hong
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Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease Biogerontology (IF 4.5) Pub Date : 2023-09-25 Mario Nieto, Mina Könisgberg, Alejandro Silva-Palacios
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Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis Biogerontology (IF 4.5) Pub Date : 2023-09-22 Kento Takaya, Toru Asou, Kazuo Kishi
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Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii Biogerontology (IF 4.5) Pub Date : 2023-09-19 Mariano Almirón, Federico H. Gomez, Pablo Sambucetti, Fabian M. Norry
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Aging adipose tissue, insulin resistance, and type 2 diabetes Biogerontology (IF 4.5) Pub Date : 2023-09-19 Yixuan Zhao, Rensong Yue
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Disrupted HSF1 regulation in normal and exceptional brain aging Biogerontology (IF 4.5) Pub Date : 2023-09-14 Rachana Trivedi, Bailey Knopf, Sharlene Rakoczy, Gunjan D. Manocha, Holly Brown-Borg, Donald A. Jurivich
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Plasma proteins as potential biomarkers of aging of single tissue and cell type Biogerontology (IF 4.5) Pub Date : 2023-09-14 Daigo Okada
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Alexey Olovnikov: theoretical biology beyond the margins Biogerontology (IF 4.5) Pub Date : 2023-09-07 Ivan A. Olovnikov
Alexey Olovnikov (1936–2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution
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MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses Biogerontology (IF 4.5) Pub Date : 2023-08-30 Yi-Sheng Khor, Pooi-Fong Wong
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Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex Biogerontology (IF 4.5) Pub Date : 2023-08-29 Arshad Ghaffari-Nasab, Gonja Javani, Gisou Mohaddes, Mohammad Reza Alipour
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Telomeres and telomerase: active but complex players in life-history decisions Biogerontology (IF 4.5) Pub Date : 2023-08-23 Radmila Čapková Frydrychová, Barbora Konopová, Vratislav Peska, Miloslav Brejcha, Michala Sábová
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Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D Biogerontology (IF 4.5) Pub Date : 2023-08-22 Fahimeh Agh, Seyed Hadi Mousavi, Naheed Aryaeian, Fatemehsadat Amiri, Mohammad Reza Jalilvand, Motahareh Hasani, Farhad Vahid, Fatemeh Sepahvand, Mehran Vosugh
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Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model Biogerontology (IF 4.5) Pub Date : 2023-08-12 Xin Yin, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao, Lixin Zhang, Xuekui Xia
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Retinal microvascular complexity as a putative biomarker of biological age: a pilot study Biogerontology (IF 4.5) Pub Date : 2023-08-12 Natasa Popovic, Maša Ždralević, Stela Vujosevic, Miroslav Radunović, Antoaneta Adžić Zečević, Isidora Rovčanin Dragović, Batrić Vukčević, Tomo Popovic, Ljiljana Radulović, Tijana Vuković, Jevto Eraković, Ranko Lazović, Miodrag Radunović
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Redox signaling and modulation in ageing Biogerontology (IF 4.5) Pub Date : 2023-08-03 Mehmet Can Atayik, Ufuk Çakatay
In spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the
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Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho Biogerontology (IF 4.5) Pub Date : 2023-07-31 Pavel Borsky, Drahomira Holmannova, Ctirad Andrys, Jan Kremlacek, Zdenek Fiala, Helena Parova, Vit Rehacek, Tereza Svadlakova, Svatopluk Byma, Otto Kucera, Lenka Borska
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Role of sestrins in metabolic and aging-related diseases Biogerontology (IF 4.5) Pub Date : 2023-07-30 Huan Fang, Xiaomin Shi, Juyi Wan, Xiaolin Zhong
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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies Biogerontology (IF 4.5) Pub Date : 2023-07-30 Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi
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Differential effects of aging on hippocampal ultrastructure in male vs. female rats Biogerontology (IF 4.5) Pub Date : 2023-07-29 Mzia Zhvania, Nadezhda Japaridze, Yousef Tizabi, Nino Lomidze, Nino Pochkhidze, Fuad Rzayev, Eldar Gasimov
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Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol Biogerontology (IF 4.5) Pub Date : 2023-07-17 Filipe Nogueira Franco, Luciana de Cassia Cardoso, Bárbara Néllita Moura Silva, Glaucy Rodrigues de Araújo, Miriam Martins Chaves
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Measuring healthy ageing: current and future tools Biogerontology (IF 4.5) Pub Date : 2023-07-13 Nádia Silva, Ana Teresa Rajado, Filipa Esteves, David Brito, Joana Apolónio, Vânia Palma Roberto, Alexandra Binnie, Inês Araújo, Clévio Nóbrega, José Bragança, Pedro Castelo-Branco
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Gastrointestinal redox homeostasis in ageing Biogerontology (IF 4.5) Pub Date : 2023-07-12 Jan Homolak
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Pax6 affects Ras-Raf-ERK1/2 in mouse aging brain Biogerontology (IF 4.5) Pub Date : 2023-07-12 Khushboo Srivastava, Rajnikant Mishra
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Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach Biogerontology (IF 4.5) Pub Date : 2023-07-10 Apoorv Sharma, Abhishek Kumar Singh
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The rosetta stone of successful ageing: does oral health have a role? Biogerontology (IF 4.5) Pub Date : 2023-07-08 Maximilian Poser, Katie E. A. Sing, Thomas Ebert, Dirk Ziebolz, Gerhard Schmalz
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Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice Biogerontology (IF 4.5) Pub Date : 2023-07-03 Kento Takaya, Toru Asou, Kazuo Kishi
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Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway Biogerontology (IF 4.5) Pub Date : 2023-06-08 Zhuang-Zhi Wang, Hai-Chen Xu, Huan-Xia Zhou, Chen-Kai Zhang, Bo-Ming Li, Jia-Han He, Pin-Shi Ni, Xiao-Ming Yu, Yun-Qing Liu, Fang-Hui Li
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Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress Biogerontology (IF 4.5) Pub Date : 2023-05-25 Ronghua Fang, Jie Chen, Jiangchuan Long, Binghan Zhang, Qixuan Huang, Shengbing Li, Ke Li, Qing Chen, Dongfang Liu
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Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases Biogerontology (IF 4.5) Pub Date : 2023-05-18 Mehran Radak, Hossein Fallahi
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Dynamics of redox signaling in aging via autophagy, inflammation, and senescence Biogerontology (IF 4.5) Pub Date : 2023-05-17 Prashanth S. Javali, Mouliganesh Sekar, Ashish Kumar, Kavitha Thirumurugan
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Lipofuscin, amyloids, and lipid peroxidation as potential markers of aging in Daphnia Biogerontology (IF 4.5) Pub Date : 2023-05-17 R. L. Lowman, L. Y. Yampolsky
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Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages Biogerontology (IF 4.5) Pub Date : 2023-05-17 Ana Gabriela Jiménez