-
Receipt of financial assistance for oral targeted therapy among older adults with advanced non-small cell lung cancer: A prospective cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-15 Anika Kumar, Meera Ragavan, Ana I. Velazquez, Sandra Zeng, Melisa L. Wong
-
Evaluation of treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy accompanied by the G-8 geriatric score: TROD13–003 multicenter study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-15 Zeliha Güzelöz, İlknur Bilkay Görken, Barbaros Aydın, Fatma Sert, Deniz Yalman, Murtaza Parvizi, Gülhan Güler Avcı, Pelin Altınok, Hatice Halis, Şefika Arzu Ergen, Züleyha Akgün, Elif Özkan, Yıldız Güney, Didem Karaçetin, Nuri Kaydıhan, Mürsel Düzova, Murat Akın, Bora Uysal, Mihriban Erdoğan, Hülya Ellidokuz, Gamze Aksu, Evrim Metcalfe
The choice of treatment for rectal cancer often differs in older and younger patients, with the rate of radiotherapy use lower among older adults. In our daily practice, when evaluating a frail older patient with rectal cancer, we usually choose to give less treatment. This may be due to concern that the patient will not be able to tolerate radiotherapy. The Geriatric 8 score (G8GS) is a guide to evaluating
-
Words matter: Use caution when interpreting study's results! J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-14 Sophie Pilleron
We read the study of Bhatt and colleagues titled “Longitudinal changes in cognitive and physical function and health-related quality of life in older adults with acute myeloid leukaemia” published in Journal of Geriatric Oncology in January 2024. We commented in regards to the importance of the wording to be used when interpreting the results of research studies.
-
Older patients' experiences with and attitudes towards an oncogeriatric pathway: A qualitative study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-14 Anna Uit den Boogaard, Dide de Jongh, Marjan J.T. van den Elst, Stella Trompet, Janneke M. de Man-van Ginkel, Johanneke E.A. Portielje, Yvette Meuleman, Simon P. Mooijaart, Nienke A. de Glas, Frederiek van den Bos
To tailor treatment for older patients with cancer, an oncogeriatric care pathway has been developed in the Leiden University Medical Center. In this care pathway a geriatric assessment is performed and preferences concerning cancer treatment options are discussed. This study aimed to explore patient experiences with and attitudes towards this pathway. A qualitative study was performed using an exploratory
-
Immunotherapy use in older adults with cancer with frailty: A young SIOG review paper J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-11 Deniz Can Guven, Bertha Alejandra Martinez-Cannon, Giuseppe Dario Testa, Janine Capobiango Martins, Rogelio N. Velasco Jr, Tania Kalsi, Fabio Gomes
Immune checkpoint inhibitors (ICIs) became a treatment option in most tumor types and improved survival in patients with cancer in the last decade. Older patients with cancer are underrepresented in the pivotal clinical trials with ICIs. Older patients with cancer often have significant comorbidities and geriatric syndromes like frailty, which can complicate cancer care and treatment decisions. Frailty
-
Immune checkpoint inhibitor doublets: Are they beneficial for older patients? A systematic review and meta-analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-11 Lorenzo Dottorini, Antonio Ghidini, Rita Deda, Italo Sarno, Matteo Cavallone, Andrea Luciani, Fausto Petrelli
The introduction of immune checkpoint inhibitors (ICIs) has significantly transformed the treatment landscape for advanced malignancies. These inhibitors bolster the immune system's capacity to detect and destroy cancer cells. ICIs used in cancer immunotherapy are primarily categorized into two groups: anti-PD-1/L1 and anti-CTLA-4. The application of combination ICI therapy (ICI doublets) in older
-
Survival outcomes in older adults undergoing early phase clinical trials J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-10 Udit Nindra, Sarah Childs, Robert Yoon, Sana Haider, Martin Hong, Aflah Roohullah, Adam Cooper, Kate Wilkinson, Abhijit Pal, Wei Chua
-
Advance care planning among older adults with cancer in the United States: Findings from the National Health and Aging Trends Study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-10 Weijiao Zhou, Shaomei Shang, Youmin Cho
-
Statin use in older adults with cancer – Experience from a dedicated geriatric oncology service J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-10 Darragh T. O'Sullivan, Darren J. Walsh, Caitriona Goggin, Anne M. Horgan
The increase in statin use, since their introduction, has been rapid and the broadening of indications has occurred seemingly without restriction. Once established on statin therapy, there is sparse research on discontinuation. Trials do not often address benefit in later life, or the impact of a life-limiting diagnosis. Data on primary prevention suggest that 100 patients need treatment for 2.5 years
-
A structured oral chemotherapy teaching tool to improve adherence in adults with multiple myeloma: A pilot randomized controlled trial J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-08 Imran Haider, Gregory R. Pond, Ruthanne Cameron, Mohammed Aljama, Tom C. Kouroukis, Kirk Wong, Mark A. Fiala, Tanya M. Wildes, Hira Mian
Many of the newer treatments for adults with newly-diagnosed and relapsed multiple myeloma (MM) are orally administered. Adherence is a challenge, and little is known about strategies to optimize adherence. Forty-seven patients initiating orally-administered anti-myeloma therapy were enrolled and randomized in a pilot study to receive either standard of care teaching or the Multinational Association
-
Cellular therapies in older adults with hematological malignancies: A case-based, state-of-the-art review J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-03-01 Nina Rosa Neuendorff, Abdullah Khan, Fabian Ullrich, Samuel Yates, Srinivas Devarakonda, Richard J. Lin, Bastian von Tresckow, Raul Cordoba, Andrew Artz, Ashley E. Rosko
Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor- (CAR-) T cell therapies are essential treatment modalities for many hematological malignancies. Although their use in older adults has substantially increased within the past decades, cellular therapies represent intensive treatment approaches
-
Assessing frailty in older Indian patients before cancer treatment: Comparative analysis of three scales and their implications for overall survival J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-29 Abhijith R. Rao, Vanita Noronha, Anant Ramaswamy, Anita Kumar, Anupa Pillai, Shreya Gattani, Arshiya Sehgal, Sharath Kumar, Renita Castelino, Jessica Pearce, Ratan Dhekale, Pravin Jagtap, Vinod Tripathi, Sunita Satamkar, Jyoti Krishnamurthy, Sarika Mahajan, Anuradha Daptardar, Lekhika Sonkusare, Jayita Deodhar, Nabila Ansari, Manjusha Vagal, Purabi Mahajan, Shivshankar Timmanpyati, Manjunath Nookala
Frailty, characterized by ageing-related vulnerability, influences outcomes in older adults. Our study aimed to investigate the relationship between frailty and clinical outcomes in older Indian patients with cancer. Our observational single-centre study, conducted at Tata Memorial Hospital from February 2020 to July 2022, enrolled participants aged 60 years and above with cancer. Frailty was assessed
-
-
Do older patients with colorectal cancer experience more deterioration in health-related quality of life than younger patients during the first year of palliative chemotherapy? A prospective real-world observational study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-15 Ingunn Hatlevoll, Are K. Kristensen, Tora S. Solheim, Hege Elvebakken, Øyvind Salvesen, Line M. Oldervoll, Arne Wibe, Eva Hofsli
The primary aim was to evaluate changes in health-related quality of life (HRQoL) in a real-life population among younger (< 70 years) and older patients with metastatic colorectal cancer (mCRC) during the first year of palliative chemotherapy. The secondary aims were to assess the impact of chemo-break on HRQoL and to report overall survival (OS). Patients with newly diagnosed mCRC, ≥ 18 years, and
-
Trends in wearable device use among cancer survivors in the United States from 2019 to 2022 J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-15 Weijiao Zhou, Youmin Cho, Junlan Pu, Shaomei Shang
-
Understanding the incidence, duration, and severity of symptoms through daily symptom monitoring among frail and non-frail older patients receiving metastatic prostate cancer treatments J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-13 Milothy Parthipan, Gregory Feng, Henriette Breunis, Narhari Timilshina, Urban Emmenegger, Aaron Hansen, George Tomlinson, Andrew Matthew, Hance Clarke, Daniel Santa Mina, Enrique Soto-Perez-de-Celis, Martine Puts, Shabbir M.H. Alibhai
Older adults with metastatic prostate cancer (mPC) experience high symptom burden associated with treatment. Frailty may exacerbate treatment toxicity. The aim of this study was to explore short-term treatment toxicity in patients with metastatic prostate cancer. Older adults with metastatic prostate cancer starting chemotherapy, androgen-receptor-axis targeted therapies, or radium-223 participated
-
Protocol for a randomized controlled trial of brief behavioral activation among older adult cancer survivors J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-10 Rebecca M. Saracino, Ellen Y. Park, Caraline Demirjian, Devika R. Jutagir, Kelly M. McConnell, Elizabeth Schofield, Patrick J. Raue, Carl W. Lejuez, Christian J. Nelson
As many as 35% of older adult cancer survivors (OACS; i.e., ≥65 years old) have clinically significant depression. OACS often experience fatigue, mild cognitive impairment, and increased medical comorbidities post-cancer that make them susceptible to depression. Behavioral activation (BA) is an empirically supported depression treatment in geriatric psychiatry that guides individuals to reengage in
-
Cancer care physicians' attitudes toward do not resuscitate orders during the COVID-19 pandemic J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-10 Anahat Kaur, Brennan Streck, Mackenzi Pergolotti, Nicolò Matteo Luca Battisti, Jessica L. Krok-Schoen, Leana Cabrera Chien, Beverly Canin, Imran Ali, Mariuxi Viteri Malone, Amy MacKenzie, Armin Shahrokni, Elana Plotkin, Leigh B. Boehmer, Karlynn BrintzenhofeSzoc
-
Patient-oncologist discussion of treatment decisions: Exploring the role of a patient-centered communication tool for older adults with acute myeloid leukemia and their caregivers J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-09 Marielle Jensen-Battaglia, Marissa LoCastro, Haejung Oh, Chandrika Sanapala, Marie Flannery, Jason H. Mendler, Jane Liesveld, Eric Huselton, Kah Poh Loh
-
Symptom networks in older adults with cancer: A network analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-09 Yi Kuang, Feng Jing, Yanling Sun, Zheng Zhu, Weijie Xing
Due to aging, older adults with cancer (OAC) may be confronted with a complex interplay of multiple age-related issues; coupled with receiving cancer treatment, OAC may experience multiple concurrent symptoms that require the identification of the core symptom for effective management. Constructing symptom networks will help in the identification of core symptoms and help achieve personalized and precise
-
Association of screening tool scores with overall survival in older patients with unresectable gastrointestinal or biliary pancreatic cancer: A retrospective study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-08 Shoko Inoo, Yoshiyasu Kono, Hiromitsu Kanzaki, Shigeru Horiguchi, Hironari Kato, Yasushi Yamasaki, Shoichiro Hirata, Sakiko Kuraoka, Katsunori Matsueda, Shotaro Okanoue, Takuya Satomi, Kenta Hamada, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada, Motoyuki Otsuka
-
Improving timeliness to initial assessment in a geriatric oncology clinic: A quality improvement project J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-06 Selynne Guo, Susie Monginot, Rana Jin, Shabbir M.H. Alibhai, Richard Norman
-
Impact of FRAilty screening and Geriatric assessment and INtervention in older patients with epithelial Ovarian Cancer: A multicenter randomized clinical trial protocol (FRAGINOC) J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-06 Cristina Daviu Cobián, Jakob O. Oreskov, Jan Blaakaer, Eva Jespersen, Trine L. Jørgensen, Jesper Ryg, Jørn Herrstedt, Claus Høgdall, Cecilia M. Lund, Lene Seibæk, Anders Vinther, Anne Weng Ekmann-Gade, Tine H. Schnack
Radical surgery combined with chemotherapy is the only potential curative treatment of patients with advanced epithelial ovarian cancer (EOC). However, 43% of older Danish patients with EOC are not referred to surgery due to frailty, age, or fear of complications. Comprehensive geriatric assessment (CGA) has demonstrated ability to reduce frailty in older patients, but there is a knowledge gap regarding
-
Comparing the use of aggressive end-of life care among frail and non-frail patients with cancer using a claims-based frailty index J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-05 Rishi Sachdev, Galen Shearn-Nance, Long Vu, Wyatt P. Bensken, Sara L. Douglas, Siran M. Koroukian, Johnie Rose
Despite mounting consensus that end-of-life (EOL) care for patients with cancer should focus on improving quality of life, many patients continue to receive aggressive, disease-oriented treatment until death. Within this group, patients with increased frailty may be at higher risk of adverse treatment-related outcomes. We therefore examined the relationship between degree of frailty and receipt of
-
The prognostic value of a geriatric risk score for older patients undergoing emergency surgery of colorectal cancer: A retrospective cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-03 Daniëlle Hultink, Esteban T.D. Souwer, Esther Bastiaannet, Jan-Willem T. Dekker, W.H. Steup, Marije E. Hamaker, Dirk J.A. Sonneveld, Esther C.J. Consten, Peter A. Neijenhuis, Johanna E.A. Portielje, Frederiek van den Bos
Emergency surgery of colorectal cancer is associated with high mortality rates in older patients. We investigated whether information on four geriatric domains has prognostic value for 30-day mortality and postoperative morbidity including severe complications. All consecutive patients aged 70 years or older who underwent emergency colorectal cancer surgery in six Dutch hospitals (2014–2017) were studied
-
Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-03 Tomonori Mizutani, Kwok-Leung Cheung, Yervand Hakobyan, Heather Lane, Lore Decoster, Theodora Karnakis, Martine Puts, Oscar Calderon, Trine L. Jørgensen, Rabia Boulahssass, Ulrich Wedding, Athanasios Karampeazis, Wendy Wing Lok Chan, Joyita Banerjee, Cristina Falci, Barbara L. van Leeuwen, Vasco Fonseca, Regina Gironés Sarrió, Marcus Vetter, Vérène Dougoud, Arash Naeim, Jed Ashman, Najia Musolino,
The Sustainable Development Goals of the United Nations include a commitment to “leave no one behind” as a universal goal. To achieve this in geriatric oncology (GO) worldwide, it is important to understand the current state of GO at an international level. The International Society of Geriatric Oncology (SIOG) has several National Representatives (NRs) who act as SIOG's delegates in their respective
-
Decreasing polypharmacy in older adults with cancer: A pilot cluster-randomized trial protocol J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-02-01 Erika Ramsdale, Mostafa Mohamed, Holly M. Holmes, Lisa Zubkoff, Jessica Bauer, Sally A. Norton, Supriya Mohile
Polypharmacy is prevalent in older adults with cancer and associated with multiple adverse outcomes. A single-site, cluster-randomized clinical trial will enroll older adults with cancer and polypharmacy starting chemotherapy and will assess the effectiveness and feasibility of deprescribing interventions by comparing two arms: a pharmacist-led deprescribing intervention and a patient educational brochure
-
Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-29 Samuel Stevens, Udit Nindra, Adel Shahnam, Joe Wei, Victoria Bray, Abhijit Pal, Po Yee Yip, Anthony Linton, Prunella Blinman, Adnan Nagrial, Jenny Lee, Michael Boyer, Steven Kao
Consolidation durvalumab following platinum-based chemoradiotherapy (CRT) significantly improved overall survival for patients with unresectable stage III non-small cell lung cancer (NSCLC) in the PACIFIC trial. However, older patients were underrepresented in PACIFIC, and subsequent analyses suggested trends toward poorer survival and increased toxicity in patients aged ≥70 years old. We assessed
-
Associations between performance-based and patient-reported physical functioning and real-world mobile sensor metrics in older cancer survivors: A pilot study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-26 Carissa A. Low, Christianna Bartel, Jennifer Fedor, Krina C. Durica, Gregory Marchetti, Andrea L. Rosso, Grace Campbell
Introduction Older cancer survivors are at increased risk for impaired physical functioning, but current assessments of function are difficult to implement in busy oncology clinics. Mobile devices measuring continuous activity and mobility in daily life may be useful for estimating physical functioning. The goal of this pilot study was to examine the associations between consumer wearable device (a
-
Esophageal cancer in octogenarians: Should esophagectomy be done? J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-28 Lisa Cooper, Ran Orgad, Yochai Levi, Hila Shmilovitch, Yael Feferman, Daniel Solomon, Hanoch Kashtan
Introduction Esophagectomy is the treatment of choice for esophageal cancer. In octogenarians data is conflicting. We evaluated postoperative outcomes and long-term survival of octogenarians and their younger counterparts. Materials and Methods A retrospective analysis of a prospectively maintained database including consecutive patients with esophageal cancer who underwent esophagectomy at a large
-
Evaluation of high-dose methotrexate completion for primary central nervous system lymphoma using modified Geriatric 8 for functional assessment: A retrospective descriptive study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-20 Satoru Matsunuma, Toru Koshiishi, Shigeki Sunaga, Kunitoshi Otsuka, Eitaro Okumura, Koichi Yoshimoto, Hiroyuki Jimbo
Abstract not available
-
How representative are participants in geriatric oncology clinical trials? The case of the 5C RCT in geriatric oncology: A cross-sectional comparison to a geriatric oncology clinic J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-15 Mohammed H. Habib, Shabbir M.H. Alibhai, Martine Puts
Introduction Frail older adults make up a substantial portion of the older adult population. However, frail patients are often excluded from randomized controlled trials. This underrepresentation restricts the extent to which trial findings can be generalized to this population. We compared a sample from the Canadian 5C Randomized Controlled Trial investigating comprehensive geriatric assessment (CGA)
-
Increasing the evidence for comprehensive geriatric assessment J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-13 Johanneke Portielje, Frederiek van den Bos
Abstract not available
-
The impact of prognostic factors and comorbidities on survival in older adults with stage I − III cutaneous melanoma in Southwest Finland: A register study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-13 Kalle E. Mattila, Helmi Vihinen, Eetu Heervä, Maria S. Nuotio, Pia Vihinen
Introduction Despite being diagnosed with thicker and more often ulcerated melanomas, cancer-specific survival (CSS) is not necessarily inferior in older adults with melanoma compared to younger patients. Materials and Methods Our aim was to evaluate the impact of baseline melanoma-specific prognostic factors and comorbidities on recurrence-free survival (RFS), CSS, and overall survival (OS) in patients
-
Association of depression with all-cause and cancer-specific mortality in older adults with cancer: Systematic review, meta-analysis, and meta-regression J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-12 Chen Ee Low, Chun En Yau, Ren Ying Tan, Vanessa Ching Shuen Ong, Roger Chun Man Ho, Cyrus Su Hui Ho, Ainsley Ryan Yan Bin Lee, Matthew Zhixuan Chen
Introduction The incidence and mortality of cancer is increasing worldwide with studies reporting that cumulative risk of cancer rises as age increases. Against the backdrop of the increasing prevalence of cancer amongst older patients, we conducted a systematic review and meta-analysis examining the depression-mortality relationship in older adults with cancer (OAC). Materials and Methods This PRISMA-adherent
-
Involvement of family members of older patients with cancer in triadic decision-making processes during medical consultations on an outpatientward - an observational exploratory study using quantitative and qualitativemethods J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-12 Bea L. Dijkman, Marie Louise Luttik, Hanneke van der Wal - Huisman, Wolter Paans, Barbara L. van Leeuwen
Introduction There is a growing interest in the involvement of family members of older patients with cancer in decision-making processes. The aim of this study is to identify how and to what extent family members, together with patients and physicians, are involved in triadic decision-making processes in clinical practice. Materials and Methods This study was conducted using an exploratory observational
-
Implementation of a geriatric oncology service at the Royal Marsden Hospital J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-13 Colm Mac Eochagain, Annie Barrell, Vanya Slavova-Boneva, Jane Murphy, Megan Pattwell, Jacqueline Cumming, Amanda Edmondson, Maureen McGinn, Emma Kipps, Martine Milton, Jo Jethwa, Alistair Ring, Nicolò Matteo Luca Battisti
Introduction Despite significant evidence supporting the benefits of comprehensive oncogeriatric assessment in the management of older patients with cancer, the adoption of specialised geriatric oncology programs in the United Kingdom remains limited. Descriptions of clinic structure and models, patient demographics and baseline characteristics, resource utilisation, and predictors of resource utilisation
-
Impact of age, comorbidity, and polypharmacy on receipt of systemic therapy in advanced cancers: A retrospective population-based study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-01-13 Rebekah Rittberg, Kathleen Decker, Pascal Lambert, Jen Bravo, Philip St. John, Donna Turner, Piotr Czaykowski, David E. Dawe
Introduction Cancer incidence, comorbidity, and polypharmacy increase with age, but the interplay between these factors on receipt of systemic therapy (ST) in advanced cancer has rarely been studied. Materials and Methods A retrospective cohort study was conducted including patients aged ≥18 years diagnosed from 2004 to 2015 with multiple myeloma (MM) (all stages), lung cancer (stage IV), and stage
-
Omission of surgery, primary endocrine therapy adherence, and effect of comorbidity in older women with estrogen receptor positive breast cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-21 Neil Carleton, Hira Abidi, Susrutha Puthanmadhom-Narayanan, Oscar C. Marroquin, Steffi Oesterreich, Emilia J. Diego, Adam M. Brufsky, Adrian V. Lee, Priscilla F. McAuliffe
Abstract not available
-
Preoperative frailty predicts postoperative falls in older patients with cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-22 Shelby Meckstroth, Amy L. Tin, Robert J. Downey, Beatriz Korc-Grodzicki, Andrew J. Vickers, Armin Shahrokni
Introduction Patient falls in the hospital lead to adverse outcomes and impaired quality of life. Older adults with cancer who are frail may be at heightened risk of falls in the postoperative period. We sought to evaluate the association between degree of preoperative frailty and risk of inpatient postoperative falls and other outcomes among older adults with cancer. Materials and Methods We identified
-
Use of surveillance mammography among older patients with a history of breast cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-18 Elizabeth Berger, Jessica B. Long, Meera Sheffrin, Meghan Lindsay, Ilana B. Richman
Abstract not available
-
The functional trajectories of older women having surgery for gynaeoncology cancer: A single site prospective observational study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-19 Fionna E. Martin, James A. Hilton, Finbarr C. Martin, Rahul Nath, Judith S.L. Partridge, Jugdeep K. Dhesi
Introduction Population aging longevity and advances in robotic surgery suggest that increasing numbers of older women having gynaeoncological surgery is likely. Postoperative morbidity and mortality are more common in older than younger women with the age-associated characteristics of multimorbidity and frailty being generally predictive of worse outcome. Priorities that inform treatment decisions
-
Relationship between patient outcomes and patterns of fragmented cancer care in older adults with gastric cancer: A nationwide cohort study in South Korea J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-16 Dong-Woo Choi, Seungju Kim, Sun Jung Kim, Dong Wook Kim, Kwang Sun Ryu, Jae Ho Kim, Yoon-Jung Chang, Kyu-Tae Han
Introduction Fragmented cancer care, defined as receipt of care from multiple hospitals, has been shown to be associated with poor patient outcomes and high expense. However, evidence regarding the effects of hospital choice by patients with cancer on overall survival are lacking. Thus, we investigated the relationship between patterns of fragmented care and five-year mortality in patients with gastric
-
Patient-reported frailty phenotype (PRFP) vs. International Myeloma Working Group frailty index (IMWG FI) proxy: A comparison between two approaches to measuring frailty J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-16 Meena N. Murugappan, Bellinda L. King-Kallimanis, Vishal Bhatnagar, Bindu Kanapuru, Joel F. Farley, Randall D. Seifert, David D. Stenehjem, Ting-Yu Chen, Erica G. Horodniceanu, Paul G. Kluetz
Introduction Frailty assessments may help to identify patients at highest risk for treatment-related toxicity, early treatment discontinuation due to toxicity, and death in Multiple Myeloma. We aimed to compare the patient-reported frailty phenotype (PRFP) and a modified version of the International Myeloma Working Group frailty index (IMWG FI) in terms of their strengths, limitations, and classification
-
Geriatric assessment-guided interventions for older adults with multiple myeloma: A feasibility and acceptability study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-16 Christopher E. Jensen, Allison M. Deal, Kirsten A. Nyrop, Maya Logan, Nicholas J. Mangieri, Martha D. Strayhorn, Jordan Miller, Hyman B. Muss, Eben I. Lichtman, Samuel M. Rubinstein, Sascha A. Tuchman
Introduction Geriatric assessment (GA)-guided supportive care programs have been successful in improving treatment outcomes for older adults with solid-organ cancers. This study aimed to evaluate the feasibility of a GA-guided supportive care program among older adults treated for multiple myeloma (MM). Materials and Methods The study utilized an existing registry of adults with plasma cell disorders
-
Correlates of frailty in older female cancer survivors J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-16 Carielle Joy Rio, Leorey N. Saligan, Xiaobai Li, Adele Crouch, Diane Von Ah
Introduction Cancer survivors are at risk of frailty because of cancer and its treatment. Understanding the factors that increase the risk of frailty is an important aspect of cancer care for the development of interventions to prevent or manage frailty, thus improving cancer survival and overall quality of life of cancer survivors. This study aimed to identify demographic, clinical, and psychosocial
-
Geriatric evaluation methods in oncology and their use in clinical studies: A systematic literature review J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-09 Amelie Stueger, Markus Joerger, Katelijne De Nys
Introduction Therapeutic options in oncology keep on expanding. Nonetheless, older adults are underrepresented in clinical trials and those enrolled often have a better health status than their average peers, resulting in a lack of representative evidence for this heterogenous population. The inclusion of older patients and a uniform categorization of “frailty” is becoming increasingly urgent. Standardized
-
Hospital use and cancer treatment by age and socioeconomic status in the last year of life: A Norwegian population-based study of patients dying of cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-07 Siri Rostoft, Michael J. Thomas, Marit Slaaen, Bjørn Møller, Arild Nesbakken, Astri Syse
Introduction Cancer is the leading cause of death in Norway. In this nationwide study we describe the number and causes of hospital admissions and treatment in the final year of life for patients who died of cancer, as well as the associations to age and socioeconomic status (SES). Materials and Methods From nationwide registries covering 2010–2014, we identified all patients who were diagnosed with
-
Measures of functional status in older patients treated with palbociclib for advanced breast cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-12-06 Meghan S. Karuturi, Joseph C. Cappelleri, Joanne L. Blum, Kamal Patel, Bijoy Telivala, Steven McCune, Juan Daniel Cuevas, Shailendra Lakhanpal, Monica Z. Montelongo, Yao Wang, Debu Tripathy, Gabrielle B. Rocque
Introduction Limited data are available on the effects of treatment for advanced breast cancer (ABC) in older patients because this population has limited enrollment in clinical trials. Data generated from the prospective, noninterventional POLARIS study of patients with hormone receptor-positive/human epidermal growth factor receptor 2–negative ABC may help bridge the gap in our understanding of the
-
The role of serum albumin in predicting hospitalization risk after chemotherapy J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-30 Isabel Tejero, Samuel Dubé, Shabbir M.H. Alibhai
Abstract not available
-
Longitudinal changes in cognitive and physical function and health-related quality of life in older adults with acute myeloid leukemia J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-24 Vijaya R. Bhatt, Christopher Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Ann Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu
Introduction Many older adults with acute myeloid leukemia (AML) do not receive chemotherapy because of physicians' and patients' concern for toxicities and functional decline. This highlights the critical and urgent need to generate knowledge of functional changes following new treatments. Materials and Methods As a part of a pragmatic single-center trial, 59 older adults ≥60 years with AML completed
-
Corrigendum to “Hospitalization due to adverse drug events in older adults with cancer: A retrospective analysis” [Journal of Geriatric Oncology Volume14 (2023)101540] J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-17 Darren J. Walsh, Laura J. Sahm, Michelle O'Driscoll, Bronagh Bolger, Hitam Ameen, Michelle Hannan, Caitriona Goggin, Anne M. Horgan
Abstract not available
-
Senotherapy, cancer, and aging J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-17 Lodovico Balducci, Claire Falandry
Introduction We aimed to highlight the effects of senotherapy on the prevention and treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent cells. These cells express the senescence-associated secretory phenotype (SASP). With production of inflammatory cytokines, growth factors, and different type of proteases, the SASP is responsible for aging-associated disability
-
Development of geriatric oncology in Latin America: A report from the Latin American Cooperative Oncology Group J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-15 Luciola Pontes Leite de Barros, Ludmila de Oliveira Muniz Koch, Jurema Telles de Oliveira Lima, Thiago Lourenço Apolinario, Aldo Lourenco Abbade Dettino, Cristiane Rios Petrarca, Janine Capobiango Martins, Polianna Mara Rodrigues de Souza, Morgani Rodrigues, Janyara Teixeira de Souza e Silva, Theodora Karnakis, Luiz Antonio Gil Junior, Marcos Goncalves Adriano Junior, Macarena Honorato, Veronica Rojas
Population aging represents a critical issue for global cancer care, notably in low- and middle-income countries (LMIC). Latin America is a large region composed of 21 countries with notable diversity in both human development and access to quality healthcare. Thus, it is necessary to understand how care for older individuals is being delivered in such large and diverse regions of the world. This review
-
Self-reported electronic symptom monitoring in older patients with multimorbidity treated for cancer: Development of a core dataset based on expert consensus, literature review, and quality of life questionnaires J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-16 P.A.L. Nelleke Seghers, Marije E. Hamaker, Shane O'Hanlon, Johanneke E.A. Portielje, Hans Wildiers, Pierre Soubeyran, Annemarie Coolbrandt, Siri Rostoft
Introduction In cancer care, symptom monitoring during treatment results in improved clinical outcomes such as improved quality of life, longer survival, and fewer hospital admissions. However, as the majority of patients with cancer are older and have multimorbidity, they may benefit from monitoring of additional symptoms. The aim of this study was to identify a core set of symptoms to monitor in
-
Risk of dementia among older patients with lymphoma: A Danish nationwide matched cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-16 Eva Futtrup Maksten, Lasse Hjort Jakobsen, Boris Modrau, Hilde Jensvoll, Kristian Hay Kragholm, Judit Mészáros Jørgensen, Michael Roost Clausen, Robert Schou Pedersen, Andriette Dessau-Arp, Thomas Stauffer Larsen, Christian Bjørn Poulsen, Anne Ortved Gang, Peter Brown, Tarec C. El-Galaly, Marianne Tang Severinsen
Introduction Treatment of lymphoma can be associated with cognitive challenges, and some patients may fear development of dementia as long-term complication. Studies report a lower risk of dementia after cancer. Some believe this difference to be a protective mechanism of cancer, others believe it to be driven by bias. The risk of developing dementia after lymphoma has not been investigated in a population-based
-
Unipedal stance time is associated with fall outcomes in older chemotherapy-treated cancer survivors: A retrospective study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-14 Brendan L. McNeish, Kim Dittus, Jurdan Mossburg, Nicholas Krant, Jack A. Steinharter, Kendall Feb, Hunter Cote, Michael K. Hehir, Rebecca Reynolds, Sarah G. Bell, Mark S. Redfern, Caterina Rosano, James K. Richardson, Noah Kolb
Abstract not available
-
Home-based versus supervised group exercise in men with prostate cancer on androgen deprivation therapy: A randomized controlled trial and economic analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-15 Shabbir M.H. Alibhai, Efthymios Papadopoulos, Daniel Santa Mina, Paul Ritvo, George Tomlinson, Catherine M. Sabiston, Sara Durbano, Karen E. Bremner, James Chiarotto, Andrew Matthew, Padraig Warde, Meagan O'Neill, S. Nicole Culos-Reed
Introduction Differences between health outcomes, participation/adoption, and cost-effectiveness of home-based (HOME) interventions and supervised group-based training (GROUP) in men with prostate cancer (PC) on androgen deprivation therapy (ADT) are currently unknown. The objective of this study was to assess the clinical efficacy, adherence, and cost-effectiveness of HOME versus GROUP in men on ADT
-
State of the scientific evidence and recommendations for the management of older patients with gastric cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-11 Irene Paredero-Pérez, Paula Jimenez-Fonseca, Juana María Cano, Virginia Arrazubi, Alberto Carmona-Bayonas, Marta Covela-Rúa, Ana Fernández-Montes, Marta Martín-Richard, Regina Gironés-Sarrió
Gastric cancer is one of the most frequent and deadly tumours worldwide. However, the evidence that currently exists for the treatment of older adults is limited and is derived mainly from clinical trials in which older patients are poorly represented. In this article, a group of experts selected from the Oncogeriatrics Section of the Spanish Society of Medical Oncology (SEOM), the Spanish Group for
-
Predictive value of the G8 screening tool for postoperative complications in older adults undergoing cancer surgery: A systematic review and meta-analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2023-11-07 Kohei Horiuchi, Toshiki Kuno, Hisato Takagi, Natalia N. Egorova, Debora Afezolli
Introduction Older adults with cancer who are being considered for cancer surgery are heterogenous, with variation in their physical, mental, and social baselines and risk of postoperative complications. Due in part to the complex nature of this population, the optimal preoperative evaluation method is not clearly defined. In this study we investigated whether geriatric-8 (G8), a screening tool for