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Trends in racial and ethnic disparities in health-related quality of life in older adults with lung cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-09-12 Basil H. Chaballout, Trudy C. Wu, Matthew J. Farrell, Nicki Karimi-Mostowfi, Wisdom Akingbemi, Tristan Grogan, Ann C. Raldow
We aimed to quantitatively examine differences in health-related quality of life (HRQOL) by race/ethnicity among older adults with lung cancer. Using the Surveillance, Epidemiology, and End Results–Medicare Health Outcomes Survey (SEER-MHOS) data set, we identified two cohorts of patients ≥65 years old with lung cancer diagnosed from 2004 to 2015 who completed the health outcomes survey within 36 months
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Adherence to enhanced recovery after surgery (ERAS) in older adults following colorectal resection J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-09-12 Marionna Cathomas, Anas Taha, Nicole Kunst, Emanuel Burri, Marcus Vetter, Raffaele Galli, Robert Rosenberg, Andres Heigl
Enhanced recovery after surgery (ERAS) is an established pathway to improve short-term outcomes in colorectal surgery. It is unclear whether the efficacy, feasibility, and safety of the ERAS protocol are similar in older and younger patients. Patients undergoing colorectal resection were prospectively included in the ERAS protocol between 2019 and 2022. The cohort was stratified according to age and
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Associations of quality of social support and accurate beliefs about curability among older adults with advanced cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-09-10 Lee A. Kehoe, Michael B. Sohn, Lu Wang, Supriya Mohile, Charles Kamen, Kim Van Orden, Megan Wells, Nikesha Gilmore, Evelyn Arana-Chicas, Abdi Gudina, Sule Yilmez, Lorraine Griggs, Kah Poh Loh
Supporting older adults with advanced cancer to better understand their disease and its prognosis is important for shared decision-making. Social support is a potentially modifiable factor that may influence disease understanding. In this study, we examined the associations of quantity and quality of social support with patients' beliefs about the curability of their advanced cancer. We performed a
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“Faith and a sunny day”: Association of patient frailty with strain experienced by informal caregivers of older adults with non-muscle-invasive bladder cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-09-07 Tullika Garg, Charu Maheshwari, Katie Frank, Alicia Johns, Kirstin Rabinowitz, John F. Danella, Halle Becker, H. Lester Kirchner, Matthew E. Nielsen, Harvey J. Cohen, Terrence E. Murphy, Carmit K. McMullen
Few studies have evaluated the potential effects of aging-related conditions like frailty in older adults with cancer on informal caregivers. Our objective was to evaluate the association between the sum total of the aging-related conditions of older adults with non-muscle-invasive bladder cancer (NMIBC) and the strain reported by their informal caregivers. We conducted an explanatory sequential mixed
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Dizziness and impaired walking balance in aging patients during chemotherapy J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-09-06 Katrine Storm Piper, Katrine Kofoed Myhre, Helle Elisabeth Jensen, Kasper Madsen, Marta Kramer Mikkelsen, Cecilia Lund
Older adults are at risk of adverse effects during chemotherapy including nausea and fatigue, but many also suffer from dizziness and peripheral neuropathy. This may lead to balance and walking impairments and increased risk of falls and affect health-related quality of life. Moreover, these symptoms are often underreported with inadequate awareness among health professionals leading to deficient focus
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Evaluating concordance between International Myeloma Working Group (IMWG) frailty score and simplified frailty scale among older adults with multiple myeloma J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-09-05 Andrew Gahagan, Supriya Maheshwari, Sunil Rangarajan, Clare Ubersax, Abigail Tucker, Christian Harmon, Monica Sai Pasala, Susan Bal, Kelly Godby, Gayathri Ravi, Luciano J. Costa, Grant R. Williams, Smita Bhatia, Smith Giri
Several frailty assessment tools exist for classifying older adults with multiple myeloma (MM) by their frailty status, such as the International Myeloma Working Group (IMWG) frailty score and the simplified frailty scale. The level of agreement between the IMWG frailty score and the simplified frailty scale remains unknown. In a cross-sectional analysis of a prospective cohort study, we identified
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Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-22 Carolyn J. Presley, Madison Grogan, Amy Compston, Karen Hock, Brittany Knauss, Elyse Redder, Nicole A. Arrato, Stephen B. Lo, Sarah Janse, Jason Benedict, Rebecca Hoyd, Nyelia Williams, Scott Hayes, Sharla Wells-Di Gregorio, Thomas M. Gill, Heather Allore, Brian Focht, Morten Quist, David P. Carbone, Daniel Spakowicz, Electra D. Paskett, Barbara L. Andersen
Novel supportive care interventions designed for an aging population with lung cancer are urgently needed. We aimed to determine the feasibility of a novel supportive care physical therapy (PT) plus progressive muscle relaxation (PMR) intervention delivered to older adults with advanced lung cancer in the United States (US). This clinical trial, Resiliency Among Older Adults Receiving Lung Cancer Treatment
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Allocation and value of curative oncological treatment in frail and fit older patients with esophageal cancer: An observational cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-12 Esmée K.J. van der Poort, Yara van Holstein, Marije Slingerland, Stella Trompet, Frederiek van den Bos, Johanneke E.A. Portielje, Ewout W. Steyerberg, M. Elske van den Akker-van Marle, Willem Jan W. Bos, Simon P. Mooijaart, Wilbert B. van den Hout
The Value-Based Health Care (VBHC) model of care provides insights into patient characteristics, outcomes, and costs of care delivery that help clinicians counsel patients. This study compares the allocation and value of curative oncological treatment in frail and fit older patients with esophageal cancer in a dedicated VBHC pathway. Data was collected from patients with primary esophageal cancer without
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Association between frailty and overall survival among older adults with hepatocellular carcinoma J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-10 Ahmet Anil Ozluk, Grant Richard Williams, Chen Dai, Jonathan Goldberg, Midhun Malla, Cameron Pywell, Krishmita Siwakoti, Darryl Alan Outlaw, Garima Gupta, Bassel El-Rayes, Smith Giri, Mehmet Akce
Older adults undergoing cancer treatment often experience more treatment-related toxicities and increased risk of mortality compared to younger patients. The role of frailty among older individuals as a predictor of outcomes has gained growing significance. We evaluated the association between frailty and overall survival (OS) in patients with hepatocellular carcinoma (HCC) ≥60 years. Older adults
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Identification of older adults with Alzheimer's and related dementias among patients newly diagnosed with cancer: A comparison of methodological approaches J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-09 Tamra Keeney, Angela Miller, Joni Gilissen, Lorinda A. Coombs, Christine S. Ritchie, Ellen P. McCarthy
Research efforts to characterize and evaluate care delivery and outcomes for older adults with cancer and comorbid dementia are limited by varied methods used to classify Alzheimer's disease and related dementias (ADRD). The purpose of this study is to evaluate differences in demographic, clinical, and cancer characteristics of people newly diagnosed with cancer and concomitant dementia comparing two
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Age-specific impact of comorbidity on postoperative outcomes in older patients with colorectal cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-06 Heleen C. van der Hulst, Jessica M. van der Bol, Esther Bastiaannet, Johanna E.A. Portielje, Jan Willem T. Dekker
Age and comorbidity are considered the strongest predictors for adverse events after colorectal cancer (CRC) surgery. We aimed to study the interaction of age and comorbidity and to gain better insight in options to improve care for the growing group of older patients. We included all patients ≥70 years undergoing elective surgery for non-metastatic CRC between 2011 and 2019 in the Netherlands. Baseline
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Management of older patients with muscle invasive bladder cancer: A retrospective observational study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-03 Auranne Winock, Loic Mourey, Stephane Gerard, Amélie Lusque, Gabor Abellan Van Kan, Stéphanie Lozanno, Gilles Bourgade, Jonathan Khalifa, Mathieu Roumiguie, Laurent Balardy
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Functional status and quality of life in older patients with advanced esophageal squamous cell cancer receiving second-line nivolumab ± ipilimumab therapy: A post hoc analysis of the phase 2, multicenter RAMONA study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-03 Moying Li, Nadja M. Meindl-Beinker, Martin Maenz, Johannes Betge, Nadine Schulte, Tianzuo Zhan, Ralf-Dieter Hofheinz, Arndt Vogel, Stefan Angermeier, Claus Bolling, Maike de Wit, Ralf Jakobs, Meinolf Karthaus, Gertraud Stocker, Peter Thuss-Patience, Tobias Leidig, Hans Bauer, Matthias P. Ebert, Nicolai Haertel
The phase 2 RAMONA study demonstrated that second-line nivolumab ± ipilimumab immunotherapy was feasible and effective in older patients with advanced esophageal squamous cell cancer (ESCC). Here, we presented results from functional status (FS) and quality-of-life (QoL) analyses. Patients aged ≥65 years with advanced ESCC and disease progression following first-line therapy were enrolled for study
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Patterns in use of palliative care in older patients with metastatic breast cancer: A National Cancer Database analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-08-01 Rima Patel, Deukwoo Kwon, Malin Hovstadius, Amy Tiersten
Timely incorporation of palliative care (PC) during treatment of patients with metastatic cancers can improve symptom management and quality of life. Older age has been associated with lower PC use in patients with cancer. The frequency by which older patients with metastatic breast cancer (MBC) receive PC is unknown. The goal of this study was to use the National Cancer Database (NCDB) to describe
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Factors affecting advance care planning in older adults with cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-07-30 Jyotsana Parajuli, Amanda Walsh, Amy Hicks, Kylie Alexandra Grant, Patricia Crane, Zhuo Job Chen, Grant R. Williams, Virginia Sun, Jamie S. Myers, Marie Bakitas
Advance care planning (ACP) has been widely endorsed and recommended for its many potential benefits, including improved end-of-life (EOL) care, enhanced satisfaction with care, and reduced anxiety and depression. However, little is known about the ACP completion rates and factors affecting ACP among older adults with cancer. This study's purpose was to examine biological, psychological, and social
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Real-world overview of therapeutic strategies and prognosis of older patients with advanced or metastatic non-small cell lung cancer from the ESME database J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-07-26 Mathilde Cabart, Loïc Mourey, David Pasquier, Sophie Schneider, Hervé Léna, Nicolas Girard, Christos Chouaid, Roland Schott, Sandrine Hiret, Didier Debieuvre, Xavier Quantin, Anne Madroszyk, Pascale Dubray-Longeras, Eric Pichon, Anne Baranzelli, Grégoire Justeau, Maurice Pérol, Lise Bosquet, Bastien Cabarrou
In France, 40% of patients diagnosed with lung cancer are ≥70 years old, but these are under-represented in clinical trials. Using data from the French Epidemiological Strategy and Medical Economics (ESME) platform on Lung Cancer (LC), the objective is to provide an overview of the management and the prognosis of older patients with advanced or metastatic non-small cell lung cancer (AM-NSCLC) in a
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Effect of comprehensive geriatric assessment on hospitalizations in older adults with frailty initiating curatively intended oncologic treatment: The PROGNOSIS-RCT study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-07-20 Ann-Kristine Weber Giger, Helena Møgelbjerg Ditzel, Marianne Ewertz, Henrik Ditzel, Trine Lembrecht Jørgensen, Per Pfeiffer, Cecilia Lund, Jesper Ryg
Frailty constitutes a risk for unplanned hospitalizations in older adults with cancer. This study examines whether comprehensive geriatric assessment (CGA) as an add-on to standard oncologic care can prevent unplanned hospitalizations in older adults with frailty and cancer who initiate curative oncological treatment. This randomized controlled trial included older adults aged ≥70 with frailty (Geriatric
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Unveiling the multi-dimensional frailty network among older cancer survivors in China: A network analysis study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-07-14 Yujia Feng, Mingzhu Su, Jiamin Wang, Li Liu, Di Shao, Xiaojie Sun
Frailty has a significant impact on the overall quality of life of older cancer survivors, but the relationships among frailty symptoms are not well understood. This study aims to explore the specific associations among multidimensional symptoms of frailty among older cancer survivors by employing network analysis to provide supportive evidence for targeted interventions in the future. Data were obtained
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Effect of polypharmacy on the outcomes of older patients with advanced non-small-cell lung cancer treated with PD-1/PD-L1 inhibitors: A retrospective cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-07-12 Noboru Morikawa, Tateaki Naito, Meiko Morita, Motoki Sekikawa, Kosei Doshita, Michitoshi Yabe, Hiroaki Kodama, Keita Miura, Yuko Iida, Nobuaki Mamesaya, Haruki Kobayashi, Ryo Ko, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Toshiaki Takahashi
The effect of polypharmacy on older patients with cancer is unclear. This study aimed to explore the effect of polypharmacy on the outcomes of treatment in older patients with advanced non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors. We retrospectively reviewed the records of older patients (aged ≥65 years) with advanced NSCLC who received PD-1/PD-L1 inhibitors with or without
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Physical decline, falls, and hospitalization among vulnerable older patients in the trajectory of colorectal cancer treatment J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-07-02 Cecilia M. Lund, Dorte L. Nielsen, Martin Schultz, Troels G. Dolin
Resilience to anticancer treatment for colorectal cancer (CRC) among older patients varies. Many experience weight loss, physical decline, falls, and hospitalization during treatment, often leading to early discontinuation of otherwise effective chemotherapy. Screening for vulnerability might help to identify patients at risk of these adverse outcomes in older adults. This is a secondary analysis from
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Association of malnutrition with geriatric assessment impairments and health-related quality of life among older adults with head and neck cancers J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-28 Krishmita Siwakoti, Lisle Nabell, Andrew M. McDonald, Grant R. Williams
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Evaluation of comprehensive geriatric assessment for older adults with pancreaticobiliary cancers: A retrospective observational study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-27 Yukari Suzuki, Kei Saito, Yousuke Nakai, Hiroki Oyama, Sachiko Kanai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Tomotaka Saito, Tsuyoshi Hamada, Naminatsu Takahara, Ryosuke Tateishi, Mitsuhiro Fujishiro
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Phase 1 clinical trials in refractory colorectal cancer: Do older patients benefit? J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-20 Sergio Vallejo, Devalingam Mahalingam, Colin Court, Norma Ketchum, Jonathan Gelfond, Joel Michalek, Sukeshi Patel Arora
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Association of frailty with health-related quality of life and survival among older adults with prostate cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-20 Krishmita Siwakoti, Christian Harmon, Mustafa Al-Obaidi, Arnab Basu, Grant R. Williams
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Skeletal muscle density performance for screening frailty in older adults with cancer and the impact of diabetes: The CARE Registry J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-18 Sydney T. Thai, Jennifer L. Lund, Charles Poole, John B. Buse, Til Stürmer, Christian A. Harmon, Mustafa Al-Obaidi, Grant R. Williams
Skeletal muscle density (SMD) measurements from imaging scans identify myosteatosis and could screen patients for geriatric assessment. We assessed SMD performance as a screening tool to identify older adults with cancer likely to be frail and who could benefit from in-depth assessment; we compared performance by sex and diabetes status. We analyzed patients in the Cancer & Aging Resilience Evaluation
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Selecting the right treatment: Health outcome priorities in older patients with bladder cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-18 Vera C. Rutten, Cornelia M. Al, Suzanne Festen, Tahlita C.M. Zuiverloon, Joost L. Boormans, Harmke A. Polinder-Bos
Selecting the appropriate treatment for older patients with non-muscle invasive (NMIBC) or muscle-invasive bladder cancer (MIBC) is challenging due to smoking-related comorbidities, treatment toxicity, and an increased risk of adverse health outcomes. Considering patient preferences prior to treatment is therefore crucial. Here, we aimed to identify the health outcome priorities of older patients with
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Palbociclib in adults aged 70 years and older with advanced breast cancer: A phase 2 multicenter trial (Alliance A171601) J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-08 Mina S. Sedrak, Minji K. Lee, Jingran Ji, Daniel V. Satele, Rachel A. Freedman, Philip D. Poorvu, Tracey O'Connor, Grant R. Williams, Judith O. Hopkins, Hyman B. Muss, Harvey Jay Cohen, Ann H. Partridge, Lisa A. Carey, Selina L. Chow, Niveditha Subbiah, Jennifer Le-Rademacher, Aminah Jatoi
Palbociclib is a widely used treatment for advanced breast cancer in older adults. However, the existing evidence regarding its safety and tolerability in this age group is inconsistent and limited to retrospective subgroup or pooled analyses. We conducted a prospective single-arm multicenter phase 2 study to evaluate the safety and tolerability of palbociclib in participants aged 70 years or older
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A comparison of treatment allocation and survival between younger and older patients with HER2-overexpressing de novo metastatic breast cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-08 Annelieke Lemij, Nienke de Glas, Judith Kroep, Sabine Siesling, Frederiek van den Bos, Esther Bastiaannet, Gerrit Jan Liefers, Johanneke Portielje
There have been several developments in the treatment of HER2-overexpressing metastatic breast cancer. However, pivotal trials mainly included younger and healthier patients, resulting in a lack of information about the benefits and harms of treatment for most older patients. The aim of this study was to provide an overview of the differences in treatment allocation and survival outcomes over time
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Assessing the ability of the Cancer and Aging Research Group tool to predict chemotherapy toxicity in older Japanese patients: A prospective observational study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-06-07 Masanobu Uchiyama, Motoyasu Miyazaki, Toshinobu Hayashi, Mototsugu Shimokawa, Takafumi Nakano, Hideki Kakimoto, Satoko Takaki, Haruka Fukue, Takafumi Inoue, Ryuichi Inoue, Kouta Mashima, Satoshi Kawata, Yasutaka Sumi, Yasuaki Igarashi, Hidetoshi Kamimura, Osamu Imakyure, Koichi Matsuo
The Cancer and Aging Research Group (CARG) prediction tool was designed in the United States to predict grade ≥ 3 chemotherapy-related adverse events (CRAE) in older patients. However, its usefulness among Japanese people, who have different sensitivities to anticancer drugs and life expectancy, remains unknown. We aimed to prospectively evaluate the utility of the CARG tool for predicting severe CRAE
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Role of frailty in predicting prognosis of older patients with lung cancer: An updated systematic review and meta-analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-31 Juanping Hu, Jiarong Lan, Guangxing Xu
Frailty is a syndrome affecting primarily older adults that can impact disease course, treatment, and outcomes in patients with lung cancer (LC). We systematically reviewed current data on the correlation between frailty and overall survival (OS), recurrence-free survival (RFS), and the risk of complications in older patients with LC. PubMed, EMBASE, and Scopus databases were searched for observational
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Prognostic awareness and willingness to explore prognosis in older adults with cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-31 Maya Abdallah, Marielle Jensen-Battaglia, Amita Patil, Grace Digiovanni, Chandrika Sanapala, Erin Watson, Marissa LoCastro, Ying Wang, Soroush Mortaz-Hedjri, Allison Magnuson, Erika Ramsdale, Colin McHugh, Kah Poh Loh
Prognostic awareness varies widely among older adults with cancer. Accurate prognostic awareness helps to ensure delivery of care that is aligned with the patient's goals. Understanding factors associated with poor prognostic awareness in older adults with cancer may help identify which patients may need interventions to improve prognostic awareness. In this study, we assessed factors associated with
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Localized prostate cancer in older patients: Radical prostatectomy or radiotherapy versus observation J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-26 Fausto Petrelli, Lorenzo Dottorini, Agostina De Stefani, Ivano Vavassori, Andrea Luciani
This study evaluates the effects of radical prostatectomy (RP) or irradiation on overall survival (OS) and prostate cancer-specific mortality (PCSM) in older patients with localized prostate cancer (PC). We conducted a comprehensive literature review across PubMed, EMBASE, and the Cochrane Library from inception up to December 2023 to identify studies comparing the outcomes of surgery or radiotherapy
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Disparities in the renal cancer mortality between Black and White adults in the United States, 1999–2020 J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-23 Khushboo Nusrat, Rafay Khan, Syed Husain Farhan, Shanza Malik, Neha Saleem Paryani, Mohammad Arham Siddiq, Roha Saeed Memon, Hafsa Jawaid, Ishaque Hameed
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Supportive care needs among older Mexican adults with metastatic cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-17 Ana Cristina Torres-Perez, Wendy Alicia Ramos-Lopez, Alfredo Covarrubias-Gómez, Sofía Sánchez-Roman, Paulina Quiroz-Friedman, Natasha Alcocer-Castillejos, María Del Pilar Milke-García, Mónica Carrillo-Soto, Andrea Morales-Alfaro, Yanin Chávarri-Guerra, Enrique Soto-Perez-de-Celis
Supportive care needs may vary according to age. The purpose of this research is to describe and compare supportive care needs between older adults with metastatic cancer (age ≥ 65 years) and their younger counterparts. We conducted a retrospective secondary analysis of a cohort of patients with newly diagnosed metastatic solid tumors. Supportive care needs were assessed at baseline and at a three-month
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Physician-level variation in axillary surgery in older adults with T1N0 hormone receptor-positive breast cancer: A retrospective population-based cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-16 Christina A. Minami, Ginger Jin, Rachel A. Freedman, Mara A. Schonberg, Tari A. King, Elizabeth A. Mittendorf
We sought to determine how considerations specific to older adults impact between- and within-surgeon variation in axillary surgery use in women ≥70 years with T1N0 HR+ breast cancer. Females ≥70 years with T1N0 HR+/HER2-negative breast cancer diagnosed from 2013 to 2015 in SEER-Medicare were identified and linked to the American Medical Association Masterfile. The outcome of interest was axillary
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Exploring the role of the oncologist in promoting shared decision making during treatment planning for older adults with acute myeloid leukemia J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-11 Marissa LoCastro, Marielle Jensen-Battaglia, Chandrika Sanapala, Rachel Rodenbach, Jason H. Mendler, Jane Liesveld, Eric Huselton, Kah Poh Loh
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Understanding health outcome preferences of older adults diagnosed with multiple myeloma J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-06 Supriya Maheshwari, Miguel Arias, Clare Ubersax, Abigail Tucker, Susan Bal, Gayathri Ravi, Kelly Godby, Luciano J. Costa, Grant R. Williams, Sadeep Shrestha, Smita Bhatia, Smith Giri
Health outcome preferences of older adults with cancer vary based on burden/intensity of treatment and its impact on health outcomes such as survival, quality of life, and functional and cognitive well-being. We studied the association between age and health outcome preferences of adults with multiple myeloma (MM). Using a single center prospective cohort study, we identified adults ≥50y with MM who
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Advanced cutaneous squamous cell carcinoma: Impact of age on the safety and efficacy of cemiplimab and the prognostic significance of blood biomarkers J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-05 Doran Ksienski, Pauline T. Truong, Jeffrey N. Bone, Sarah Egli, Melissa Clarkson, Tiffany Patterson, Mary Lesperance, Suganija Lakkunarajah
Age-related differences in the safety profile of cemiplimab for patients with locally advanced or metastatic cutaneous squamous cell carcinoma (cSCC) have not been well described. We investigated the association of increasing age with immune related adverse events (irAE) from cemiplimab, efficacy outcomes, and the prognostic significance of pre-treatment blood biomarkers in contemporary practice. Patients
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Association between preoperative social frailty and malnutrition six months post-surgery in older patients with gastrointestinal cancer: A prospective cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-04 Mayu Mizuta, Shin Kondo, Akihiko Hibi, Yuya Ueda, Daisuke Makiura, Rei Ono, Toshihiro Akisue
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Shared decision-making support program for older patients with advanced cancer using a question prompt list and geriatric assessment: A pilot randomized controlled trial J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-04 Kyoko Obama, Maiko Fujimori, Narikazu Boku, Ayumu Matsuoka, Keita Mori, Ayumi Okizaki, Tempei Miyaji, Masako Okamura, Yoshiyuki Majima, Shinichi Goto, Taichi Shimazu, Yosuke Uchitomi
Older patients with cancer are less likely to express their treatment preferences than younger patients. Question prompt lists (QPLs) facilitate communication between patients and physicians. Geriatric assessment (GA) is recommended when older patients with cancer make treatment decisions. This study estimated the effect size of a shared decision-making (SDM) support program combining QPLs with GA
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Patient-reported outcomes and experiences from a prospective cohort study of older patients with cancer on checkpoint inhibitors: The ELDERS study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-04 Fabio Gomes, Binish Khatoon, Chelsea Sawyer, Grant Punnett, Naomi Farrington, Janelle Yorke
Checkpoint inhibitors (CPI) are widely used across different tumour types in older cancer patients. The ELDERS study investigated primarily the safety of CPI in older patients, and secondarily its impact on health-related quality of life (HRQoL), comparing older and younger patients. Here we describe the results from its secondary aim. This was an observational, mixed methods study, consisting of questionnaires
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The rates of septicemia in older adults with prostate cancer treated with abiraterone or enzalutamide: A population-based study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-05-03 Nikita Nikita, Krupa Gandhi, Scott W. Keith, Swapnil Sharma, Wm Kevin Kelly, Grace Lu-Yao
Prostate cancer (PCa) is the most common non-cutaneous tumor among American men. Androgen receptor signaling inhibitors such as abiraterone and enzalutamide have been approved for similar disease states among patients with advanced PCa. Existing data suggest using steroids is associated with an increased risk of infection. Because abiraterone is usually prescribed with prednisone, we sought to compare
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Perspectives on geriatric oncology research presented at the 2023 San Antonio Breast Cancer Symposium: A Young International Society of Geriatric Oncology report J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-27 Wing-Lok Chan, Ting-Yan Vanessa Yeung, Mukul Roy, Hing-Wai Wong, Chiu-Ki Astor Mak, Chun-Yuet Janice Leung
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The geriatric assessment and sarcopenia to assess frailty in older patients with cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-27 Christiaan D.A. Meerkerk, Cheryl P. Bruijnen, Frederiek van den Bos, Marielle H. Emmelot-Vonk, Remco de Bree
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Emergency presentation of colorectal cancer in older adults: A retrospective cohort analysis J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-27 Jennifer H. Nobes, Mark A. Baxter, Craig Mowat
Adults aged 70 years and over account for almost 60% of colorectal cancer (CRC) diagnoses in the United Kingdom. Whilst emergency presentation of CRC is known to be associated with poorer outcomes across all ages, older adults are less likely to be treated with curative intent and have poorer overall survival (OS). We aimed to investigate whether presentation, management, or outcome differed in older
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Predictors of high-intensity care at the end of life among older adults with solid tumors: A population-based study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-26 Courtney E. Baird, Elizabeth Wulff-Burchfield, Pamela C. Egan, Lee A. Hugar, Ami Vyas, Nikolaos A. Trikalinos, Michael A. Liu, Emmanuelle Bélanger, Adam J. Olszewski, Leonidas E. Bantis, Orestis A. Panagiotou
High-intensity end-of-life (EoL) care can be burdensome for patients, caregivers, and health systems and does not confer any meaningful clinical benefit. Yet, there are significant knowledge gaps regarding the predictors of high-intensity EoL care. In this study, we identify risk factors associated with high-intensity EoL care among older adults with the four most common malignancies, including breast
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The association between polypharmacy and health-related quality of life among older adults with prostate cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-26 Zongliang Yue, Xiangzhong Xue, Jingjing Qian
Older adults with prostate cancer (PC) are at risk of polypharmacy, which further complicates disease management and health-related quality of life (HRQoL). This study evaluated the association between polypharmacy and HRQoL among Medicare beneficiaries with PC. This observational, retrospective study analyzed data from the Surveillance, Epidemiology, and End Results (SEER) Medicare Health Outcomes
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Associations between frailty trajectories with multidimensional health outcomes among older cancer survivors: A nationally representative cohort study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-25 Junlan Pu, Weijiao Zhou, Tao Liu, Wen Zeng, Shaomei Shang
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Comparing Mini-Cog and Blessed Orientation-Memory-Concentration test for evaluating cognition in older patients with advanced cancer J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-16 Kaitlin Kyi, William Consagra, Eva Culakova, Lucia Berkhof, Michelle Janelsins, Alison Conlin, James Bearden III, Jeffrey Berenberg, Beverly Canin, Supriya Mohile, Allison Magnuson
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The SaVe project – Sarcopenia and Vertigo in aging patients with colorectal cancer: A study protocol for three randomized controlled trials J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-16 Katrine Storm Piper, Charlotte Suetta, Jakob Vasehus Schou, Jesper Ryg, Hanne Elkjær Andersen, Line Vind Langevad, Delaney Evering, Marta Kramer Mikkelsen, Cecilia Lund, Jan Christensen
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Oncology care providers' perceptions and anticipated barriers regarding the use of geriatric assessment in routine clinic practice: A mixed-methods study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-15 Schroder Sattar, Kristen R. Haase, Martine Puts, Mohammed Iddrisu, Haji Chalchal, Osama Souied, Shabbir M.H. Alibhai, Shahid Ahmed
Geriatric assessment (GA) is currently not a standard of cancer care across Canada. In the Canadian province of Saskatchewan, there are no known formal geriatric teams in outpatient oncology settings. Therefore, it is not known whether, how, and to what extent GA is performed in oncology clinics, or what supports are needed to carry out a GA. The objective of this study was to explore Saskatchewan
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Value of a multidisciplinary geriatric oncology committee on patient care in a community-based, academic cancer center J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-13 Gurbani Singh, Lena Morant, McKenzie Bedra, Jennifer Emel, Kelly Harris, Yudhishtra Markan, Christopher de Borja, Monica Tong, Patrice Downs, Cherif Boutros
The heterogeneity in health and functional ability among older patients makes the management of cancer a unique challenge The Geriatric Oncology Program at the University of Maryland Baltimore Washington Medical Center (BWMC) was created to optimize cancer management for older patients. This study aimed to assess the benefits of the implementation of such a program at a community-based academic cancer
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Perspectives on geriatric oncology research presented at the 2023 American Society of Hematology Annual Meeting: Young International Society of Geriatric Oncology report J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-11 Maya Abdallah, Othman Salim Akhtar, Ajay Major, Hira Mian, Mazie Tsang, Pallawi Torka
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Prevalence and impact of frailty and geriatric assessment-identified impairments among older adults diagnosed with head and neck cancers J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-05 Krishmita Siwakoti, Smith Giri, Lisle Nabell, Noam A. VanderWalde, Andrew McDonald, Grant R. Williams
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The association of chemotherapy-induced peripheral neuropathy with reduced executive function in chemotherapy-treated cancer survivors: A cross-sectional study J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-05 Brendan L. McNeish, Kim Dittus, Jurdan Mossburg, Nicholas Krant, John A. Steinharter, Kendall Feb, Hunter Cote, Michael K. Hehir, Rebecca Reynolds, Mark S. Redfern, Caterina Rosano, James K. Richardson, Noah Kolb
Chemotherapy-induced peripheral neuropathy (CIPN) is common and disabling among cancer survivors. Little is known about the association of CIPN with other measures of the nervous system's integrity, such as executive dysfunction. We compared measures of executive function in older chemotherapy-treated cancer survivors with and without CIPN. This cross-sectional study enrolled 50 chemotherapy-treated
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Study protocol for two stepped-wedge interventional trials evaluating the effects of holistic information technology-based patient-oriented management in older multimorbid patients with cancer: The GERONTE trials J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-05 Marije E. Hamaker, Hans Wildiers, Vittoria Ardito, Julie Arsandaux, Aurore Barthod-Malat, Paul Davies, Lien Degol, Lucia Ferrara, Celia Fourrier, Cindy Kenis, Marion Kret, Caroline Lalet, Simone Mathoulin Pelissier, Shane O'Hanlon, Siri Rostoft, Nelleke Seghers, Florence Saillour-Glénisson, Anthony Staines, Christine Schwimmer, Vincent Thevenet, Cedric Wallet, Pierre Soubeyran
Current hospital-based care pathways are generally single-disease centred. As a result, coexisting morbidities are often suboptimally evaluated and managed, a deficiency becoming increasingly apparent among older patients who exhibit heterogeneity in health status, functional abilities, frailty, and other geriatric impairments. To address this issue, our study aims to assess a newly developed patient-centred
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Outcomes in studies regarding older patients with prostate cancer: A systematic review J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-04 Kim F.T. Jochems, Dominik Menges, Dafne Sanchez, Nienke A. de Glas, Hans Wildiers, Daniel Eberli, Milo A. Puhan, Esther Bastiaannet
Older patients are often deemed ineligible for clinical research, and many frequently-used endpoints and outcome measures are not as relevant for older patients for younger ones. This systematic review aimed to present an overview of outcomes used in clinical research regarding patients over the age of 65 years with prostate cancer. PubMed and Embase were systematically searched to identify studies
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Geriatric assessment-identified impairments and frailty in adults with cancer younger than 65: An opportunity to optimize oncology care J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-03 Mackenzi Pergolotti, Kelley C. Wood, Mary Hidde, Tiffany D. Kendig, Ellen A. Ronnen, Smith Giri, Grant R. Williams
Frailty, a state of increased vulnerability to stressors due to aging or treatment-related accelerated aging, is associated with declines in physical, cognitive and/or social functioning, and quality of life for cancer survivors. For survivors aged <65 years, little is known about frailty status and associated impairments to inform intervention. We aimed to evaluate the prevalence of frailty and contributing
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Response to the letter to the editor J. Geriatr. Oncol. (IF 3.0) Pub Date : 2024-04-03 Vijaya R. Bhatt