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Quantitative SPECT imaging of 155Tb and 161Tb for preclinical theranostic radiopharmaceutical development EJNMMI Phys. (IF 3.0) Pub Date : 2024-09-14 Helena Koniar, Scott McNeil, Luke Wharton, Aidan Ingham, Michiel Van de Voorde, Maarten Ooms, Sathiya Sekar, Cristina Rodríguez-Rodríguez, Peter Kunz, Valery Radchenko, Arman Rahmim, Carlos Uribe, Hua Yang, Paul Schaffer
Element-equivalent matched theranostic pairs facilitate quantitative in vivo imaging to establish pharmacokinetics and dosimetry estimates in the development of preclinical radiopharmaceuticals. Terbium radionuclides have significant potential as matched theranostic pairs for multipurpose applications in nuclear medicine. In particular, 155Tb (t1/2 = 5.32 d) and 161Tb (t1/2 = 6.89 d) have been proposed
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Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-30 William M. Steinberger, Lorenzo Mercolli, Johannes Breuer, Hasan Sari, Szymon Parzych, Szymon Niedzwiecki, Gabriela Lapkiewicz, Pawel Moskal, Ewa Stepien, Axel Rominger, Kuangyu Shi, Maurizio Conti
Positron emission tomography (PET) traditionally uses coincident annihilation photons emitted from a positron interacting with an electron to localize cancer within the body. The formation of positronium (Ps), a bonded electron-positron pair, has not been utilized in clinical applications of PET due to the need to detect either the emission of a prompt gamma ray or the decay of higher-order coincident
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Feasibility of a deep-inspiration breath-hold [18F]AlF-NOTA-LM3 PET/CT imaging on upper-abdominal lesions in NET patients: in comparison with respiratory-gated PET/CT EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-29 Haiqiong Zhang, Meixi Liu, Ximin Shi, Jiangyu Ma, Chao Ren, Zhenghai Huang, Ying Wang, Hongli Jing, Li Huo
To explore the clinical feasibility and efficacy of a deep inspiration breath-hold (BH) PET/CT using [18F]AlF-NOTA-LM3 on upper abdominal lesions in patients with neuroendocrine tumors (NETs). Twenty-three patients underwent a free-breath (FB) whole-body PET/CT, including a 10 min/bed scan for the upper abdomen with a vital signal monitoring for respiratory gating (RG) followed by a 20-second BH PET/CT
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From SPECT/CT towards absolute quantification? - the case of unilateral condylar hyperplasia of the mandible EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-23 Stijn De Schepper, Gopinath Gnanasegaran, Wouter De Vos, Elke Van de Casteele, John C. Dickson, Tim Van den Wyngaert
Unilateral condylar hyperplasia (UCH) of the mandible is a rare condition characterized by asymmetric growth of the mandibular condyles. Bone scintigraphy with SPECT(/CT) is commonly used to diagnose UCH and guide treatment. Still, varying results have been reported using the traditional threshold of 55%:45% in relative tracer uptake. While absolute quantification of uptake on SPECT/CT could improve
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Design and proof of concept of a double-panel TOF-PET system EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-23 Andrea Gonzalez-Montoro, Noriel Pavón, Julio Barberá, Neus Cuarella, Antonio J. González, Santiago Jiménez-Serrano, Alejandro Lucero, Laura Moliner, David Sánchez, Koldo Vidal, José M. Benlloch
Positron Emission Tomography (PET) is a well-known imaging technology for the diagnosis, treatment, and monitoring of several diseases. Most PET scanners use a Ring-Shaped Detector Configuration (RSDC), which helps obtain homogeneous image quality but are restricted to an invariable Field-of-View (FOV), scarce spatial resolution, and low sensitivity. Alternatively, few PET systems use Open Detector
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Subtraction of single-photon emission computed tomography (SPECT) in radioembolization: a comparison of four methods EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-15 Camiel E. M. Kerckhaert, Hugo W. A. M. de Jong, Marjolein B. M. Meddens, Rob van Rooij, Maarten L. J. Smits, Yothin Rakvongthai, Martijn M. A. Dietze
Subtraction of single-photon emission computed tomography (SPECT) images has a number of clinical applications in e.g. foci localization in ictal/inter-ictal SPECT and defect detection in rest/stress cardiac SPECT. In this work, we investigated the technical performance of SPECT subtraction for the purpose of quantifying the effect of a vasoconstricting drug (angiotensin-II, or AT2) on the Tc-99m-MAA
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Dosimetric implications of kidney anatomical volume changes in 177Lu-DOTATATE therapy EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-02 Jehangir Khan, Tobias Rydèn, Martijn Van Essen, Johanna Svensson, Joseph Grudzinski, Peter Bernhardt
This study aims to evaluate the use of CT-based whole kidney parenchyma (WKP) segmentation in 177Lu-DOTATATE dosimetry. Specifically, it investigates whether WKP volumes change during treatment and evaluates the accuracy of applying a single delineated WKP volume for dosimetry. Furthermore, it aims to determine the cause of WKP volume changes—whether caused by radiation or amino acid infusion—by comparing
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Automatic reorientation to generate short-axis myocardial PET images EJNMMI Phys. (IF 3.0) Pub Date : 2024-08-02 Yuling Yang, Fanghu Wang, Xu Han, Hui Xu, Yangmei Zhang, Weiping Xu, Shuxia Wang, Lijun Lu
Accurately redirecting reconstructed Positron emission tomography (PET) images into short-axis (SA) images shows great significance for subsequent clinical diagnosis. We developed a system for automatic redirection and quantitative analysis of myocardial PET images. A total of 128 patients were enrolled for 18 F-FDG PET/CT myocardial metabolic images (MMIs), including 3 image classifications: without
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Performance evaluation of the 3D-ring cadmium–zinc–telluride (CZT) StarGuide system according to the NEMA NU 1-2018 standard EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-25 Alessandra Zorz, Marco Andrea Rossato, Paolo Turco, Luca Maria Colombo Gomez, Andrea Bettinelli, Francesca De Monte, Marta Paiusco, Pietro Zucchetta, Diego Cecchin
The application of semi-conductor detectors such as cadmium–zinc–telluride (CZT) in nuclear medicine improves extrinsic energy resolution and count sensitivity due to the direct conversion of gamma photons into electric signals. A 3D-ring pixelated CZT system named StarGuide was recently developed and implemented by GE HealthCare for SPECT acquisition. The system consists of 12 detector columns with
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Estimation of kidney doses from [177Lu]Lu-DOTA-TATE PRRT using single time point post-treatment SPECT/CT EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-25 Safia Spink, Daniel Gillett, Sarah Heard, Ines Harper, Ruth Casey, Luigi Aloj
Dosimetry after [177Lu]Lu-DOTA-TATE therapy can be demanding for both patients and the clinical service due to the need for imaging at several time points. In this work we compare three methods of single time point (STP) kidney dosimetry after [177Lu]Lu-DOTA-TATE therapy with a multiple time point (MTP) dosimetry method. Method 1 (MTP): Kidney doses were calculated from 31 patients including 107 therapy
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Multi-modal co-learning with attention mechanism for head and neck tumor segmentation on 18FDG PET-CT EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-25 Min Jeong Cho, Donghwi Hwang, Si Young Yie, Jae Sung Lee
Effective radiation therapy requires accurate segmentation of head and neck cancer, one of the most common types of cancer. With the advancement of deep learning, people have come up with various methods that use positron emission tomography-computed tomography to get complementary information. However, these approaches are computationally expensive because of the separation of feature extraction and
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Artificial intelligence-based joint attenuation and scatter correction strategies for multi-tracer total-body PET EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-19 Hao Sun, Yanchao Huang, Debin Hu, Xiaotong Hong, Yazdan Salimi, Wenbing Lv, Hongwen Chen, Habib Zaidi, Hubing Wu, Lijun Lu
Low-dose ungated CT is commonly used for total-body PET attenuation and scatter correction (ASC). However, CT-based ASC (CT-ASC) is limited by radiation dose risks of CT examinations, propagation of CT-based artifacts and potential mismatches between PET and CT. We demonstrate the feasibility of direct ASC for multi-tracer total-body PET in the image domain. Clinical uEXPLORER total-body PET/CT datasets
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A review of 177Lu dosimetry workflows: how to reduce the imaging workloads? EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-18 Laure Vergnaud, Yuni K. Dewaraja, Anne-Laure Giraudet, Jean-Noël Badel, David Sarrut
$$^{177}{\hbox {Lu}}$$ radiopharmaceutical therapy is a standardized systemic treatment, with a typical dose of 7.4 GBq per injection, but its response varies from patient to patient. Dosimetry provides the opportunity to personalize treatment, but it requires multiple post-injection images to monitor the radiopharmaceutical’s biodistribution over time. This imposes an additional imaging burden on
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Deep learning-based measurement of split glomerular filtration rate with 99mTc-diethylenetriamine pentaacetic acid renal scan EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-17 Sejin Ha, Byung Soo Park, Sangwon Han, Jungsu S. Oh, Sun Young Chae, Jae Seung Kim, Dae Hyuk Moon
To develop a deep learning (DL) model for generating automated regions of interest (ROIs) on 99mTc-diethylenetriamine pentaacetic acid (DTPA) renal scans for glomerular filtration rate (GFR) measurement. Manually-drawn ROIs retrieved from a Picture Archiving and Communications System were used as ground-truth (GT) labels. A two-dimensional U-Net convolutional neural network architecture with multichannel
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Organ and tumor dosimetry including method simplification for [177Lu]Lu-PSMA-I&T for treatment of metastatic castration resistant prostate cancer EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-17 Amir Karimzadeh, Linus Schatz, Markus Sauer, Ivayla Apostolova, Ralph Buchert, Susanne Klutmann, Wencke Lehnert
Internal dosimetry in individual patients is essential for safe and effective radioligand therapy. Multiple time point imaging for accurate dosimetry is time consuming and hence can be demanding for nuclear medicine departments as well as patients. The objectives of this study were (1) to assess absorbed doses to organs at risk and tumor lesions for [177Lu]Lu-PSMA-I&T using whole body SPECT imaging
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Pareto optimization of SPECT acquisition and reconstruction settings for 177Lu activity quantification EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-15 Johan Gustafsson, Erik Larsson, Michael Ljungberg, Katarina Sjögreen Gleisner
The aim was to investigate the noise and bias properties of quantitative 177Lu-SPECT with respect to the number of projection angles, and the number of subsets and iterations in the OS-EM reconstruction, for different total acquisition times. Experimental SPECT acquisition of six spheres in a NEMA body phantom filled with 177Lu was performed, using medium-energy collimators and 120 projections with
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Comparison of the dosimetry of scandium-43 and scandium-44 patient organ doses in relation to commonly used gallium-68 for imaging neuroendocrine tumours EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-15 Carlos Vinícius Gomes, Bruno Melo Mendes, Lucas Paixão, Silvano Gnesin, Cristina Müller, Nicholas P. van der Meulen, Klaus Strobel, Telma Cristina Ferreira Fonseca, Thiago Viana Miranda Lima
Several research groups have explored the potential of scandium radionuclides for theragnostic applications due to their longer half-lives and equal or similar coordination chemistry between their diagnostic and therapeutic counterparts, as well as lutetium-177 and terbium-161, respectively. Unlike the gallium-68/lutetium-177 pair, which may show different in-vivo uptake patterns, the use of scandium
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Radiomics incorporating deep features for predicting Parkinson’s disease in 123I-Ioflupane SPECT EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-10 Han Jiang, Yu Du, Zhonglin Lu, Bingjie Wang, Yonghua Zhao, Ruibing Wang, Hong Zhang, Greta S. P. Mok
123I-Ioflupane SPECT is an effective tool for the diagnosis and progression assessment of Parkinson’s disease (PD). Radiomics and deep learning (DL) can be used to track and analyze the underlying image texture and features to predict the Hoehn-Yahr stages (HYS) of PD. In this study, we aim to predict HYS at year 0 and year 4 after the first diagnosis with combined imaging, radiomics and DL-based features
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Timing limits of ultrafast cross-luminescence emission in CsZnCl-based crystals for TOF-CT and TOF-PET EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-09 Katrin Herweg, Daniel Rutstrom, Vanessa Nadig, Luis Stand, Charles L. Melcher, Mariya Zhuravleva, Volkmar Schulz, Stefan Gundacker
Good timing resolution in medical imaging applications such as TOF-CT or TOF-PET can boost image quality or patient comfort significantly by reducing the influence of background noise. However, the timing resolution of state-of-the-art detectors in CT and PET are limited by their light emission process. Core-valence cross-luminescence is an alternative, but well-known compounds (e.g. BaF2) pose several
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Deep learning based bilateral filtering for edge-preserving denoising of respiratory-gated PET EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-09 Jens Maus, Pavel Nikulin, Frank Hofheinz, Jan Petr, Anja Braune, Jörg Kotzerke, Jörg van den Hoff
Residual image noise is substantial in positron emission tomography (PET) and one of the factors limiting lesion detection, quantification, and overall image quality. Thus, improving noise reduction remains of considerable interest. This is especially true for respiratory-gated PET investigations. The only broadly used approach for noise reduction in PET imaging has been the application of low-pass
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Seracam: characterisation of a new small field of view hybrid gamma camera for nuclear medicine EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-08 Sarah L. Bugby, Andrew L. Farnworth, William R. Brooks, Alan C. Perkins
Portable gamma cameras are being developed for nuclear medicine procedures such as thyroid scintigraphy. This article introduces Seracam® – a new technology that combines small field of view gamma imaging with optical imaging – and reports its performance and suitability for small organ imaging. The count rate capability, uniformity, spatial resolution, and sensitivity for 99mTc are reported for four
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Kinetic model-informed deep learning for multiplexed PET image separation EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-01 Bolin Pan, Paul K. Marsden, Andrew J. Reader
Multiplexed positron emission tomography (mPET) imaging can measure physiological and pathological information from different tracers simultaneously in a single scan. Separation of the multiplexed PET signals within a single PET scan is challenging due to the fact that each tracer gives rise to indistinguishable 511 keV photon pairs, and thus no unique energy information for differentiating the source
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A practical method for measuring planar spatial resolution with scatter on a CZT gamma camera EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-01 Corinne Barrau, Perrine Tylski
This study proposes a practical method for evaluating 2D spatial resolution with scatter on a CZT planar detector gamma camera, which is simpler and faster than the NEMA method. It is used to characterize the influence of distance on spatial resolution FWHM on a CZT camera equipped with a WEHR collimator. The practical method uses linear sources tilted with respect to the detector axes. The spatial
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Preliminary protocol for measuring the reproducibility and accuracy of flow values on digital PET/CT systems in [15O]H2O myocardial perfusion imaging using a flow phantom EJNMMI Phys. (IF 3.0) Pub Date : 2024-07-01 Reetta Siekkinen, Heidi Partanen, Linda Kukola, Tuula Tolvanen, Andrew Fenwick, Nadia A. S. Smith, Mika Teräs, Antti Saraste, Jarmo Teuho
Several factors may decrease the accuracy of quantitative PET myocardial perfusion imaging (MPI). It is therefore essential to ensure that myocardial blood flow (MBF) values are reproducible and accurate, and to design systematic protocols to achieve this. Until now, no systematic phantom protocols have been available to assess the technical factors affecting measurement accuracy and reproducibility
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Improvements of 177Lu SPECT images from sparsely acquired projections by reconstruction with deep-learning-generated synthetic projections EJNMMI Phys. (IF 3.0) Pub Date : 2024-06-28 Emma Wikberg, Martijn van Essen, Tobias Rydén, Johanna Svensson, Peter Gjertsson, Peter Bernhardt
For dosimetry, the demand for whole-body SPECT/CT imaging, which require long acquisition durations with dual-head Anger cameras, is increasing. Here we evaluated sparsely acquired projections and assessed whether the addition of deep-learning-generated synthetic intermediate projections (SIPs) could improve the image quality while preserving dosimetric accuracy. This study included 16 patients treated
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Position dependence of recovery coefficients in 177Lu-SPECT/CT reconstructions – phantom simulations and measurements EJNMMI Phys. (IF 3.0) Pub Date : 2024-06-28 Julian Leube, Wies Claeys, Johan Gustafsson, Maikol Salas-Ramirez, Michael Lassmann, Michel Koole, Johannes Tran-Gia
Although the importance of quantitative SPECT has increased tremendously due to newly developed therapeutic radiopharmaceuticals, there are still no accreditation programs to harmonize SPECT imaging. Work is currently underway to develop an accreditation for quantitative 177Lu SPECT/CT. The aim of this study is to verify whether the positioning of the spheres within the phantom has an influence on
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DosePatch: physics-inspired cropping layout for patch-based Monte Carlo simulations to provide fast and accurate internal dosimetry EJNMMI Phys. (IF 3.0) Pub Date : 2024-06-26 Francesca De Benetti, Julia Brosch-Lenz, Jorge Mario Guerra González, Carlos Uribe, Matthias Eiber, Nassir Navab, Thomas Wendler
Dosimetry-based personalized therapy was shown to have clinical benefits e.g. in liver selective internal radiation therapy (SIRT). Yet, there is no consensus about its introduction into clinical practice, mainly as Monte Carlo simulations (gold standard for dosimetry) involve massive computation time. We addressed the problem of computation time and tested a patch-based approach for Monte Carlo simulations
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Accuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging EJNMMI Phys. (IF 3.0) Pub Date : 2024-06-20 Michaella Morphis, Johan A. van Staden, Hanlie du Raan, Michael Ljungberg, Katarina Sjögreen Gleisner
This study aimed to assess the accuracy of patient-specific absorbed dose calculations for tumours and organs at risk in radiopharmaceutical therapy planning, utilizing hybrid planar-SPECT/CT imaging. Three Monte Carlo (MC) simulated digital patient phantoms were created, with time-activity data for mIBG labelled to I-123 (LEHR and ME collimators) and I-131 (HE collimator). The study assessed the accuracy
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Improving diagnostic precision in amyloid brain PET imaging through data-driven motion correction EJNMMI Phys. (IF 3.0) Pub Date : 2024-06-14 Hye Lim Park, Sonya Youngju Park, Mingeon Kim, Soyeon Paeng, Eun Jeong Min, Inki Hong, Judson Jones, Eun Ji Han
Head motion during brain positron emission tomography (PET)/computed tomography (CT) imaging degrades image quality, resulting in reduced reading accuracy. We evaluated the performance of a head motion correction algorithm using 18F-flutemetamol (FMM) brain PET/CT images. FMM brain PET/CT images were retrospectively included, and PET images were reconstructed using a motion correction algorithm: (1)
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Does consensus contour improve robustness and accuracy in 18F-FDG PET radiomic features? EJNMMI Phys. (IF 3.0) Pub Date : 2024-06-06 Mingzan Zhuang, Xianru Li, Zhifen Qiu, Jitian Guan
The purpose of our study is to validate the robustness and accuracy of consensus contour in 2-deoxy-2-[ $$^{18}$$ F]fluoro-D-glucose ( $$^{18}$$ F-FDG) PET radiomic features. 225 nasopharyngeal carcinoma (NPC) and 13 extended cardio-torso (XCAT) simulated data were enrolled. All segmentation were performed with four segmentation methods under two different initial masks, respectively. Consensus contour
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Signal separation of simultaneous dual-tracer PET imaging based on global spatial information and channel attention EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-29 Jingwan Fang, Fuzhen Zeng, Huafeng Liu
Simultaneous dual-tracer positron emission tomography (PET) imaging efficiently provides more complete information for disease diagnosis. The signal separation has long been a challenge of dual-tracer PET imaging. To predict the single-tracer images, we proposed a separation network based on global spatial information and channel attention, and connected it to FBP-Net to form the FBPnet-Sep model.
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An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-29 Grace Keane, Rob van Rooij, Marnix Lam, S. Cheenu Kappadath, Bilal Kovan, Stephanie Leon, Matthew Dreher, Kirk Fowers, Hugo de Jong
Personalised multi-compartment dosimetry based on [99mTc]Tc-MAA is a valuable tool for planning 90Y radioembolization treatments. The establishment and effective application of dose–effect relationships in yttrium-90 (90Y) radioembolization requires [99mTc]Tc-MAA SPECT quantification ideally independent of clinical site. The purpose of this multi-centre phantom study was to evaluate inter-site variability
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Ultra-low foetal radiation exposure in 18F-FDG PET/CT imaging with a long axial field-of-view PET/CT system EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-24 Charlotte L. C. Smith, Maqsood Yaqub, Ruud H. H. Wellenberg, Jelijn J. Knip, Ronald Boellaard, Gerben J. C. Zwezerijnen
Long axial field-of-view (LAFOV) PET/CT systems enable PET/CT scans with reduced injected activities because of improved sensitivity. With this study, we aimed to examine the foetal radiation dose from an 18F-FDG PET/CT scan on a LAFOV PET/CT system with reduced injected activity. Two pregnant women were retrospectively included and received an 18F-FDG PET/CT scan on a LAFOV PET/CT system with an intravenous
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Evaluation of lesion contrast in the walk-through long axial FOV PET scanner simulated with XCAT anthropomorphic phantoms EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-09 Meysam Dadgar, Jens Maebe, Stefaan Vandenberghe
This study evaluates the lesion contrast in a cost-effective long axial field of view (FOV) PET scanner, called the walk-through PET (WT-PET). The scanner consists of two flat detector panels covering the entire torso and head, scanning patients in an upright position for increased throughput. High-resolution, depth-of-interaction capable, monolithic detector technology is used to provide good spatial
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The significance of partial volume effect on the estimation of hypoxic tumour volume with [18F]FMISO PET/CT EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-09 Athanasios Kafkaletos, Michael Mix, Ilias Sachpazidis, Montserrat Carles, Alexander Rühle, Juri Ruf, Anca L. Grosu, Nils H. Nicolay, Dimos Baltas
The purpose of this study was to evaluate how a retrospective correction of the partial volume effect (PVE) in [18F]fluoromisonidazole (FMISO) PET imaging, affects the hypoxia discoverability within a gross tumour volume (GTV). This method is based on recovery coefficients (RC) and is tailored for low-contrast tracers such as FMISO. The first stage was the generation of the scanner’s RC curves, using
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Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-09 Monika Tulik, Radosław Kuliński, Zbisław Tabor, Beata Brzozowska, Piotr Łaba, Frank Bruchertseifer, Alfred Morgenstern, Leszek Królicki, Jolanta Kunikowska
A new, alternative option for patients with recurrent glioblastoma is targeted alpha therapy (TAT), in the form of a local administration of substance P (neurokinin type 1 receptor ligand, NK-1) labelled with 225Ac. The purpose of the study was to confirm the feasibility of quantitative SPECT imaging of 225Ac, in a model reproducing specific conditions of TAT. In particular, to present the SPECT calibration
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Data-driven gating (DDG)-based motion match for improved CTAC registration EJNMMI Phys. (IF 3.0) Pub Date : 2024-05-01 Ella L. Cook, Kuan-Hao Su, Geoff S. Higgins, Robert Johnsen, Jean-Paul Bouhnik, Daniel R. McGowan
Respiratory motion artefacts are a pitfall in thoracic PET/CT imaging. A source of these motion artefacts within PET images is the CT used for attenuation correction of the images. The arbitrary respiratory phase in which the helical CT ( $$\hbox{CT}_{\text{helical}}$$ ) is acquired often causes misregistration between PET and CT images, leading to inaccurate attenuation correction of the PET image
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11C-CFT PET brain imaging in Parkinson’s disease using a total-body PET/CT scanner EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-25 Xiaolin Sun, Xiaoyue Tan, Qing Zhang, Shanzhen He, Siyun Wang, Yongrong Zhou, Qi Huang, Lei Jiang
This study aimed to evaluate the feasibility of 11C-CFT PET brain imaging in Parkinson’s Disease using a total-body PET/CT scanner and explore the optimal scan duration to guide the clinical practice. Thirty-two patients with Parkinson’s disease (PD) performing 11C-CFT PET/CT brain imaging using a total-body PET/CT scanner were retrospectively enrolled. The PET data acquired over a period of 900 s
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Quantification of biochemical PSA dynamics after radioligand therapy with [177Lu]Lu-PSMA-I&T using a population pharmacokinetic/pharmacodynamic model EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-24 Hinke Siebinga, Berlinda J. de Wit-van der Veen, Daphne M. V. de Vries-Huizing, Wouter V. Vogel, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema
There is an unmet need for prediction of treatment outcome or patient selection for [177Lu]Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Quantification of the tumor exposure–response relationship is pivotal for further treatment optimization. Therefore, a population pharmacokinetic (PK) model was developed for [177Lu]Lu-PSMA-I&T using SPECT/CT data and, subsequently
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Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-22 Lara Struelens, Christelle Huet, David Broggio, Jérémie Dabin, Laurent Desorgher, Augusto Giussani, Wei Bo Li, Dietmar Nosske, Yi-Kang Lee, Lidia Cunha, Maria J. R. Carapinha, Mario Medvedec, Peter Covens
In order to ensure adequate radiation protection of critical groups such as staff, caregivers and the general public coming into proximity of nuclear medicine (NM) patients, it is necessary to consider the impact of the radiation emitted by the patients during their stay at the hospital or after leaving the hospital. Current risk assessments are based on ambient dose rate measurements in a single position
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Phantom and clinical evaluation of the Bayesian penalised likelihood reconstruction algorithm Q.Clear without PSF correction in amyloid PET images EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-22 Kei Wagatsuma, Muneyuki Sakata, Kenta Miwa, Yumi Hamano, Hirofumi Kawakami, Yuto Kamitaka, Tensho Yamao, Noriaki Miyaji, Kenji Ishibashi, Tetsuro Tago, Jun Toyohara, Kenji Ishii
Bayesian penalised likelihood (BPL) reconstruction, which incorporates point-spread-function (PSF) correction, provides higher signal-to-noise ratios and more accurate quantitation than conventional ordered subset expectation maximization (OSEM) reconstruction. However, applying PSF correction to brain PET imaging is controversial due to Gibbs artefacts that manifest as unpredicted cortical uptake
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Extended MRI-based PET motion correction for cardiac PET/MRI EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-06 Mueez Aizaz, Jochem A. J. van der Pol, Alina Schneider, Camila Munoz, Robert J. Holtackers, Yvonne van Cauteren, Herman van Langen, Joan G. Meeder, Braim M. Rahel, Roel Wierts, René M. Botnar, Claudia Prieto, Rik P. M. Moonen, M. Eline Kooi
A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the PET data acquired during the acquisition of the 3D whole-heart MRI is corrected for respiratory motion. This study introduces and evaluates an MRI-based respiratory motion correction method of the complete PET data. Twelve oncology
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Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-06 David Kästner, Anja Braune, Claudia Brogsitter, Robert Freudenberg, Jörg Kotzerke, Enrico Michler
The administration of a 166Ho scout dose is available as an alternative to 99mTc particles for pre-treatment imaging in Selective Internal Radiation Therapy (SIRT). It has been reported that the 166Ho scout dose may be more accurate for the prediction of microsphere distribution and the associated therapy planning. The aim of the current study is to compare the scintigraphic imaging characteristics
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Bone marrow dosimetry in low volume mHSPC patients receiving Lu-177-PSMA therapy using SPECT/CT EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-03 Dagmar Grob, Bastiaan M. Privé, Constantijn H. J. Muselaers, Niven Mehra, James Nagarajah, Mark W. Konijnenberg, Steffie M. B. Peters
Bone marrow toxicity in advanced prostate cancer patients who receive [177Lu]Lu-PSMA-617 is a well-known concern. In early stage patients; e.g. low volume metastatic hormone sensitive prostate cancer (mHSPC) patients, prevention of late bone marrow toxicity is even more crucial due to longer life expectancy. To date, bone marrow dosimetry is primarily performed using blood sampling. This method is
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Impact of scatter correction on personalized dosimetry in selective internal radiotherapy using 166Ho-PLLA: a single-center study including Monte-Carlo simulation, phantom and patient imaging EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-02 Benoît Collette, Marie Mannie-Corbisier, Ana-Maria Bucalau, Nicolas Pauly, Gontran Verset, Rodrigo Moreno-Reyes, Patrick Flamen, Nicola Trotta
Developments in transarterial radioembolization led to the conception of new microspheres loaded with holmium-166 (166Ho). However, due to the complexity of the scatter components in 166Ho single photon emission computed tomography (SPECT), questions about image quality and dosimetry are emerging. The aims of this work are to investigate the scatter components and correction methods to propose a suitable
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Impact of different models based on blood samples and images for bone marrow dosimetry after 177Lu-labeled somatostatin-receptor therapy EJNMMI Phys. (IF 3.0) Pub Date : 2024-04-02 Delphine Vallot, Séverine Brillouet, Séléna Pondard, Lavinia Vija, Jean-Sébastien Texier, Lawrence Dierickx, Frédéric Courbon
Peptide receptor radionuclide therapy with 177Lu-DOTATATE is a recognized option for treating neuroendocrine tumors and has few toxicities, except for the kidneys and bone marrow. The bone marrow dose is generally derived from a SPECT/CT image-based method with four timepoints or from a blood-based method with up to 9 timepoints, but there is still no reference method. This retrospective single-center
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Optimising total knee replacement imaging: a novel 3D printed PET/CT anthropomorphic phantom for metal artefact simulation EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-28 Rajeh Assiri, Karen Knapp, Jon Fulford, Junning Chen
Arthroplasty phantoms, including total knee replacement (TKR) phantoms, have been frequently used to test metal artefact reduction methods applied to positron emission tomography/computed tomography (PET/CT) images. These phantoms generally simulate either simple anatomical features or simple activity distribution around the metal inserts in the PET/CT scans. 3D printing has been used recently to fabricate
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Assessment of the axial resolution of a compact gamma camera with coded aperture collimator EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-21 Tobias Meißner, Laura Antonia Cerbone, Paolo Russo, Werner Nahm, Jürgen Hesser
Handheld gamma cameras with coded aperture collimators are under investigation for intraoperative imaging in nuclear medicine. Coded apertures are a promising collimation technique for applications such as lymph node localization due to their high sensitivity and the possibility of 3D imaging. We evaluated the axial resolution and computational performance of two reconstruction methods. An experimental
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Comparison of a 3D CZT and conventional SPECT/CT system for quantitative Lu-177 SPECT imaging EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-19 Victor Nuttens, Georg Schramm, Yves D’Asseler, Michel Koole
Next-generation SPECT/CT systems with CdZnTe (CZT) digital detectors in a ring-like setup are emerging to perform quantitative Lu-177 SPECT imaging in clinical routine. It is essential to assess how the shorter acquisition time might affect the image quality and uncertainty on the mean absorbed dose of the tumors and organs at risk compared to a conventional system. A NEMA Image Quality phantom was
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Sequential deep learning image enhancement models improve diagnostic confidence, lesion detectability, and image reconstruction time in PET EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-15 Meghi Dedja, Abolfazl Mehranian, Kevin M. Bradley, Matthew D. Walker, Patrick A. Fielding, Scott D. Wollenweber, Robert Johnsen, Daniel R. McGowan
Investigate the potential benefits of sequential deployment of two deep learning (DL) algorithms namely DL-Enhancement (DLE) and DL-based time-of-flight (ToF) (DLT). DLE aims to enhance the rapidly reconstructed ordered-subset-expectation-maximisation algorithm (OSEM) images towards block-sequential-regularised-expectation-maximisation (BSREM) images, whereas DLT aims to improve the quality of BSREM
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Reduction of [68Ga]Ga-DOTA-TATE injected activity for digital PET/MR in comparison with analogue PET/CT EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-15 Christina P. W. Cox, Tessa Brabander, Erik Vegt, Quido G. de Lussanet de la Sablonière, Laura H. Graven, Frederik A. Verburg, Marcel Segbers
New digital detectors and block-sequential regularized expectation maximization (BSREM) reconstruction algorithm improve positron emission tomography (PET)/magnetic resonance (MR) image quality. The impact on image quality may differ from analogue PET/computed tomography (CT) protocol. The aim of this study is to determine the potential reduction of injected [68Ga]Ga-DOTA-TATE activity for digital
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155Tb production by cyclotrons: what level of 155Gd enrichment allows clinical applications? EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-15 Francesca Barbaro, Luciano Canton, Nikolay Uzunov, Laura De Nardo, Laura Melendez-Alafort
155Tb represents a potentially useful radionuclide for diagnostic medical applications, but its production remains a challenging problem, in spite of the fact that many production routes have been already investigated and tested. A recent experimental campaign, conducted with low-energy proton beams impinging on a 155Gd target with 91.9% enrichment, demonstrated a significant co-production of 156gTb
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Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-13 Xavier Palard-Novello, Denise Visser, Nelleke Tolboom, Charlotte L. C. Smith, Gerben Zwezerijnen, Elsmarieke van de Giessen, Marijke E. den Hollander, Frederik Barkhof, Albert D. Windhorst, Bart NM van Berckel, Ronald Boellaard, Maqsood Yaqub
Accurate image-derived input function (IDIF) from highly sensitive large axial field of view (LAFOV) PET/CT scanners could avoid the need of invasive blood sampling for kinetic modelling. The aim is to validate the use of IDIF for two kinds of tracers, 3 different IDIF locations and 9 different reconstruction settings. Eight [18F]FDG and 10 [18F]DPA-714 scans were acquired respectively during 70 and
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Development and validation of a prognostic nomogram model in locally advanced NSCLC based on metabolic features of PET/CT and hematological inflammatory indicators EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-05 Congjie Wang, Jian Fang, Tingshu Jiang, Shanliang Hu, Ping Wang, Xiuli Liu, Shenchun Zou, Jun Yang
We combined the metabolic features of 18F-FDG-PET/CT and hematological inflammatory indicators to establish a predictive model of the outcomes of patients with locally advanced non-small cell lung cancer (LA-NSCLC) receiving concurrent chemoradiotherapy. A predictive nomogram was developed based on sex, CEA, systemic immune-inflammation index (SII), mean SUV (SUVmean), and total lesion glycolysis (TLG)
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Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-05 Fen Du, Xieraili Wumener, Yarong Zhang, Maoqun Zhang, Jiuhui Zhao, Jinpeng Zhou, Yiluo Li, Bin Huang, Rongliang Wu, Zeheng Xia, Zhiheng Yao, Tao Sun, Ying Liang
This study aimed to evaluate the clinical feasibility of early 30-minute dynamic 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) positron emission tomography (PET) scanning protocol for patients with lung lesions in comparison to the standard 65-minute dynamic FDG-PET scanning as a reference. Dynamic 18F-FDG PET images of 146 patients with 181 lung lesions (including 146 lesions confirmed by histology) were
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Correction: Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography EJNMMI Phys. (IF 3.0) Pub Date : 2024-03-04 Sara de Scals, Luis Mario Fraile, José Manuel Udías, Laura Martínez Cortés, Marta Oteo, Miguel Ángel Morcillo, José Luis Carreras-Delgado, María Nieves Cabrera-Martín, Samuel España
Correction: EJNMMI Phys11, 12 (2024). https://doi.org/10.1186/s40658-024-00618-2 Following publication of the original article [1], the authors requested to update the Funding section. The original Funding sections was: This work was funded by the Universidad Complutense de Madrid under Project PR27/21 − 009 and by the Ministerio de Ciencia e Innovación under Project TED2021-129933B-C21. S. España
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Effect of kilovoltage and quality reference mAs on CT-based attenuation correction in 177Lu SPECT/CT imaging: a phantom study EJNMMI Phys. (IF 3.0) Pub Date : 2024-02-26 Maikol Salas-Ramirez, Julian Leube, Michael Lassmann, Johannes Tran-Gia
CT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect of kilovoltage peak (kVp) and quality-reference mAs (QRM) on the attenuation coefficient image (μ-map) and volume CT dose index (CTDIvol) have not yet been systematically evaluated. Therefore, the aim of this study was to fill this gap and investigate the influence
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Kinetic 18F-FDG PET/CT imaging of hepatocellular carcinoma: a dual input four-compartment model EJNMMI Phys. (IF 3.0) Pub Date : 2024-02-22 Tao Wang, Yinglei Deng, Sidan Wang, Jianfeng He, Shaobo Wang
The endoplasmic reticulum plays an important role in glucose metabolism and has not been explored in the kinetic estimation of hepatocellular carcinoma (HCC) via 18F-fluoro-2-deoxy-d-glucose PET/CT. A dual-input four-compartment (4C) model, regarding endoplasmic reticulum was preliminarily used for kinetic estimation to differentiate 28 tumours from background liver tissue from 24 patients with HCC
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Fit of biokinetic data in molecular radiotherapy: a machine learning approach EJNMMI Phys. (IF 3.0) Pub Date : 2024-02-22 Davide Ciucci, Bartolomeo Cassano, Salvatore Donatiello, Federica Martire, Antonio Napolitano, Claudia Polito, Elena Solfaroli Camillocci, Gianluca Cervino, Ludovica Pungitore, Claudio Altini, Maria Felicia Villani, Milena Pizzoferro, Maria Carmen Garganese, Vittorio Cannatà
In literature are reported different analytical methods (AM) to choose the proper fit model and to fit data of the time-activity curve (TAC). On the other hand, Machine Learning algorithms (ML) are increasingly used for both classification and regression tasks. The aim of this work was to investigate the possibility of employing ML both to classify the most appropriate fit model and to predict the
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Quantitative calibration of Tb-161 SPECT/CT in view of personalised dosimetry assessment studies EJNMMI Phys. (IF 3.0) Pub Date : 2024-02-19 Lachlan McIntosh, Price Jackson, Brittany Emmerson, James P. Buteau, Ramin Alipour, Grace Kong, Michael S. Hofman
Terbium-161 (161Tb)-based radionuclide therapy poses an alternative to current Lutetium-177 (177Lu) approaches with the additional benefit of secondary Auger and conversion electron emissions capable of delivering high doses of localised damage to micro-metastases including single cells. Quantitative single-photon emission computed tomography, paired with computed tomography (SPECT/CT), enables quantitative