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Prognostic analysis of radiation-induced liver damage following carbon-ion radiotherapy for hepatocellular carcinoma Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-22 Kazuhiko Hayashi, Osamu Suzuki, Yushi Wakisaka, Koji Ichise, Hirofumi Uchida, Makoto Anzai, Azusa Hasegawa, Yuji Seo, Shinichi Shimizu, Takayoshi Ishii, Teruki Teshima, Jiro Fujimoto, Kazuhiko Ogawa
Radiation-induced liver damage (RILD) occasionally occurs following carbon-ion radiotherapy (CIRT) for liver tumors, such as hepatocellular carcinoma (HCC), in patients with impaired liver function disease. However, the associated risk factors remain unknown. The present study aimed to determine the risk factors of RILD after CIRT. We retrospectively analyzed 108 patients with HCC treated with CIRT
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Survival analysis after stereotactic ablative radiotherapy for early stage non-small cell lung cancer: a single-institution cohort study Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-18 Kamila Resova, Lukas Knybel, Tereza Parackova, Marian Rybar, Karel Cwiertka, Jakub Cvek
Stereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC), but which patients benefit from stereotactic radiotherapy is unclear. The aim of this study was to analyze prognostic factors for early mortality. From August 2010 to 2022, 617 patients with medically inoperable, peripheral or central ES-NSCLC were treated
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Current practices of craniospinal irradiation techniques in Turkey: a comprehensive dosimetric analysis Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-16 Öznur Şenkesen, Evrim Tezcanlı, Fadime Alkaya, Burçin İspir, Serap Çatlı, Abdullah Yeşil, Ebrar Bezirganoglu, Sezgi Turan, Canan Köksal, Gülay Güray, Emel Hacıislamoğlu, İsmail Faruk Durmuş, Şeyma Çavdar, Telat Aksu, Nurten Çolak, Esra Küçükmorkoç, Mustafa Doğan, Tülay Ercan, Fatih Karaköse, Vildan Alpan, Cemile Ceylan, Gökhan Poyraz, Nilgül Nalbant, Şeyda Kınay, Servet İpek, Namık Kayalılar, Hamza
This study evaluates various craniospinal irradiation (CSI) techniques used in Turkish centers to understand their advantages, disadvantages and overall effectiveness, with a focus on enhancing dose distribution. Anonymized CT scans of adult and pediatric patients, alongside target volumes and organ-at-risk (OAR) structures, were shared with 25 local radiotherapy centers. They were tasked to develop
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Pelvic target volume inter-fractional motion during radiotherapy for cervical cancer with daily iterative cone beam computed tomography Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-15 Zheng Zeng, Jiawei Zhu, Zhiqun Wang, Guangyu Wang, Junfang Yan, Fuquan Zhang
Tumor regression and organ movements indicate that a large margin is used to ensure target volume coverage during radiotherapy. This study aimed to quantify inter-fractional movements of the uterus and cervix in patients with cervical cancer undergoing radiotherapy and to evaluate the clinical target volume (CTV) coverage. This study analyzed 303 iterative cone beam computed tomography (iCBCT) scans
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Pamiparib as consolidation treatment after concurrent chemoradiotherapy of limited-stage small cell lung cancer: a single-arm, open-label phase 2 trial Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-12 Jiuang Mao, Jianjiao Ni, Li Chu, Xiao Chu, Dayu Xu, Xi Yang, Zhengfei Zhu
Small cell lung cancer (SCLC) is highly invasive with poor prognosis, and its treatment has historically been hindered due to the absence of targetable driver genomic alterations. However, the high genomic instability and replication stress in SCLC have made poly(ADP-ribose) polymerases (PARPs) inhibitors a focus of research. Pamiparib is an orally available PARP1/2 inhibitor with high selectivity
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Effects of bone marrow sparing radiotherapy on acute hematologic toxicity for patients with locoregionally advanced cervical cancer: a prospective phase II randomized controlled study Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-09 Wen Li, Lan Ma, Fang Li, Kemin Li, Yang Zhang, Hongtao Ren, Xing Bao, Yuyan Guo, Ya Guo, Mincong Wang, Dan Li, Yuanqiong Duan, Xiulong Ma, Zhongwei Wang, Yali Wang, Rutie Yin
To evaluate effects of bone marrow sparing (BMS) radiotherapy on decreasing the incidence of acute hematologic toxicity (HT) for locoregionally advanced cervical cancer (LACC) patients treated by pelvic irradiation. LACC patients were recruited prospectively from May 2021 to May 2022 at a single center and were evenly randomized into the BMS group and the control group. All patients received pelvic
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Multi-institutional evaluation of a Pareto navigation guided automated radiotherapy planning solution for prostate cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-08 Philip A Wheeler, Nicholas S West, Richard Powis, Rhydian Maggs, Michael Chu, Rachel A Pearson, Nick Willis, Bartlomiej Kurec, Katie L. Reed, David G. Lewis, John Staffurth, Emiliano Spezi, Anthony E. Millin
Current automated planning solutions are calibrated using trial and error or machine learning on historical datasets. Neither method allows for the intuitive exploration of differing trade-off options during calibration, which may aid in ensuring automated solutions align with clinical preference. Pareto navigation provides this functionality and offers a potential calibration alternative. The purpose
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Impact of FAPI-46/dual-tracer PET/CT imaging on radiotherapeutic management in esophageal cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-04-04 Simone Wegen, Karina Claus, Philipp Linde, Johannes Rosenbrock, Maike Trommer, Thomas Zander, Armin Tuchscherer, Christiane Bruns, Hans Anton Schlößer, Wolfgang Schröder, Marie-Lisa Eich, Thomas Fischer, Klaus Schomäcker, Alexander Drzezga, Carsten Kobe, Katrin Sabine Roth, Jasmin Josefine Weindler
Fibroblast activation protein (FAP) is expressed in the tumor microenvironment (TME) of various cancers. In our analysis, we describe the impact of dual-tracer imaging with Gallium-68-radiolabeled inhibitors of FAP (FAPI-46-PET/CT) and fluorodeoxy-D-glucose (FDG-PET/CT) on the radiotherapeutic management of primary esophageal cancer (EC). 32 patients with EC, who are scheduled for chemoradiation, received
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Real world clinical experience using daily intelligence-assisted online adaptive radiotherapy for head and neck cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-30 Philip Blumenfeld, Eduard Arbit, Robert Den, Ayman Salhab, Tal Falick Michaeli, Marc Wygoda, Yair Hillman, Raphael M. Pfeffer, Marcel Fang, Yael Misrati, Noam Weizman, Jon Feldman, Aron Popovtzer
Head and neck cancers account for approximately 4% of all cancers globally and are associated with significant morbidity and mortality [1]. Locally advanced head and neck cancers pose a significant challenge due to the complex anatomy and critical structures surrounding the tumor. The management of these cancers often involves a combination of surgery, chemotherapy and radiation therapy. The delivery
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Efficacy and toxicity of photon, proton, and carbon ion radiotherapy in the treatment of intracranial solitary fibrous tumor/hemangiopericytoma Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-29 Mike Ton, Maximilian Deng, Eva Meixner, Tanja Eichkorn, Anna Krämer, Katharina Seidensaal, Juliane Hörner-Rieber, Jonathan Lischalk, Klaus Herfarth, Jürgen Debus, Laila König
Solitary fibrous tumors (SFT) of the central nervous system are rare and treatment options are not well established. The aim of this study was to evaluate the clinical outcomes of radiotherapy (RT) and re-radiotherapy (re-RT) for de novo intracranial SFT and recurrent intracranial SFT. This retrospective study analyzed efficacy and toxicity of different RT modalities in patients who received radiotherapy
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Correction: Evolution of radiation-induced temporal lobe injury after intensity-modulated radiation therapy in nasopharyngeal carcinoma: a large cohort retrospective study Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-27 Jing Hou, Yun He, Handong Li, Zhaodong Ai, Qiang Lu, Biao Zeng, Chuanmiao Xie, Xiaoping Yu
Correction: Radiation Oncology (2024) 19:9 https://doi.org/10.1186/s13014-024-02400-1 After publication of this article, the authors reported that in the caption to Fig. 5, the phrase “After 10.03 months, the white matter lesion and contrast-enhanced lesion regressed in the right temporal lobe but increased in size in the left temporal lobe (c, d)” should have read “After 10.03 months, the white matter
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MR compatible detectors assessment for a 0.35 T MR-linac commissioning Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-20 Michel Chea, Mathilde Croisé, Christelle Huet, Céline Bassinet, Mohamed-Amine Benadjaoud, Catherine Jenny
To assess a large panel of MR compatible detectors on the full range of measurements required for a 0.35 T MR-linac commissioning by using a specific statistical method represented as a continuum of comparison with the Monte Carlo (MC) TPS calculations. This study also describes the commissioning tests and the secondary MC dose calculation validation. Plans were created on the Viewray TPS to generate
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Automatic IMRT treatment planning through fluence prediction and plan fine-tuning for nasopharyngeal carcinoma Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-20 Wenwen Cai, Shouliang Ding, Huali Li, Xuanru Zhou, Wen Dou, Linghong Zhou, Ting Song, Yongbao Li
At present, the implementation of intensity-modulated radiation therapy (IMRT) treatment planning for geometrically complex nasopharyngeal carcinoma (NPC) through manual trial-and-error fashion presents challenges to the improvement of planning efficiency and the obtaining of high-consistency plan quality. This paper aims to propose an automatic IMRT plan generation method through fluence prediction
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Radiation therapy for retroperitoneal sarcoma: practice patterns in North America Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-16 Samantha M. Ruff, Victor Heh, David J. Konieczkowski, Amblessed Onuma, Hayley M. Dunlop, Alex C. Kim, Valerie P. Grignol, Carlo M. Contreras, Timothy M. Pawlik, Raphael Pollock, Joal D. Beane
The addition of radiation therapy (RT) to surgery in retroperitoneal sarcoma (RPS) remains controversial. We examined practice patterns in the use of RT for patients with RPS over time in a large, national cohort. Patients in the National Cancer Database (2004–2017) who underwent resection of RPS were included. Trends over time for proportions were calculated using contingency tables with Cochran-Armitage
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Channel-wise attention enhanced and structural similarity constrained cycleGAN for effective synthetic CT generation from head and neck MRI images Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-14 Changfei Gong, Yuling Huang, Mingming Luo, Shunxiang Cao, Xiaochang Gong, Shenggou Ding, Xingxing Yuan, Wenheng Zheng, Yun Zhang
Magnetic resonance imaging (MRI) plays an increasingly important role in radiotherapy, enhancing the accuracy of target and organs at risk delineation, but the absence of electron density information limits its further clinical application. Therefore, the aim of this study is to develop and evaluate a novel unsupervised network (cycleSimulationGAN) for unpaired MR-to-CT synthesis. The proposed cycleSimulationGAN
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Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-14 A. M. Saeed, S. M. Bentzen, H. Ahmad, L. Pham, G. F. Woodworth, M. V. Mishra
Treatment related lymphopenia is a known toxicity for glioblastoma (GBM) patients and several single-institution studies have linked lymphopenia with poor survival outcomes. We performed a systematic review and pooled analysis to evaluate the association between lymphopenia and overall survival (OS) for GBM patients undergoing chemotherapy and radiation therapy (RT). Following PRISMA guidelines, a
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Apparent diffusion coefficient values predict response to brachytherapy in bulky cervical cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-13 Elizabeth E. Dong, Junqian Xu, Joo-Won Kim, Jason Bryan, Jewel Appleton, Daniel A. Hamstra, Michelle S. Ludwig, Alexander N. Hanania
Diffusion-weighted magnetic resonance imaging (DWI) provides a measurement of tumor cellularity. We evaluated the potential of apparent diffusion coefficient (ADC) values obtained from post-external beam radiation therapy (EBRT) DWI and prior to brachytherapy (BT) to predict for complete metabolic response (CMR) in bulky cervical cancer. Clinical and DWI (b value = 500 s/mm2) data were obtained from
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FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-12 EC Daugherty, Y Zhang, Z Xiao, AE Mascia, M Sertorio, J Woo, C McCann, KJ Russell, RA Sharma, D Khuntia, JD Bradley, CB Simone, JC Breneman, JP Perentesis
FLASH therapy is a treatment technique in which radiation is delivered at ultra-high dose rates (≥ 40 Gy/s). The first-in-human FAST-01 clinical trial demonstrated the clinical feasibility of proton FLASH in the treatment of extremity bone metastases. The objectives of this investigation are to assess the toxicities of treatment and pain relief in study participants with painful thoracic bone metastases
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“sCT-Feasibility” - a feasibility study for deep learning-based MRI-only brain radiotherapy Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-08 Johanna Grigo, Juliane Szkitsak, Daniel Höfler, Rainer Fietkau, Florian Putz, Christoph Bert
Radiotherapy (RT) is an important treatment modality for patients with brain malignancies. Traditionally, computed tomography (CT) images are used for RT treatment planning whereas magnetic resonance imaging (MRI) images are used for tumor delineation. Therefore, MRI and CT need to be registered, which is an error prone process. The purpose of this clinical study is to investigate the clinical feasibility
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Protocol of a phase II study to evaluate the efficacy and safety of deep-inspiration breath-hold daily online adaptive radiotherapy for centrally located lung tumours (PUDDING study) Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-08 Noriko Kishi, Masahiro Yoneyama, Hiroyuki Inoo, Minoru Inoue, Hiraku Iramina, Akiyoshi Nakakura, Tomohiro Ono, Hideaki Hirashima, Takanori Adachi, Norimasa Matsushita, Makoto Sasaki, Takahiro Fujimoto, Mitsuhiro Nakamura, Yukinori Matsuo, Takashi Mizowaki
Centrally located lung tumours present a challenge because of their tendency to exhibit symptoms such as airway obstruction, atelectasis, and bleeding. Surgical resection of these tumours often requires sacrificing the lungs, making definitive radiotherapy the preferred alternative to avoid pneumonectomy. However, the proximity of these tumours to mediastinal organs at risk increases the potential
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Repeatability quantification of brain diffusion-weighted imaging for future clinical implementation at a low-field MR-linac Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-06 Moritz Rabe, Olaf Dietrich, Robert Forbrig, Maximilian Niyazi, Claus Belka, Stefanie Corradini, Guillaume Landry, Christopher Kurz
Longitudinal assessments of apparent diffusion coefficients (ADCs) derived from diffusion-weighted imaging (DWI) during intracranial radiotherapy at magnetic resonance imaging-guided linear accelerators (MR-linacs) could enable early response assessment by tracking tumor diffusivity changes. However, DWI pulse sequences are currently unavailable in clinical practice at low-field MR-linacs. Quantifying
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Consideration of image guidance in patterns of failure analyses of intensity-modulated radiotherapy for head and neck cancer: a systematic review Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-05 Paul-Henry Mackeprang, Katarina Bryjova, Astrid E. Heusel, Dominik Henzen, Melissa Scricciolo, Olgun Elicin
Intensity-modulated radiation therapy (IMRT) is considered standard of care for head and neck squamous cell carcinoma (HNSCC). Improved conformity of IMRT and smaller margins, however, have led to concerns of increased rates of marginal failures. We hypothesize that while patterns of failure (PoF) after IMRT for HNSCC have been published before, the quality of patient positioning and image guided radiotherapy
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High-volume prostate biopsy core involvement is not associated with an increased risk of cancer recurrence following 5-fraction stereotactic body radiation therapy monotherapy Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-04 Jonathan W. Lischalk, Astrid Sanchez, Vianca F. Santos, Christopher Mendez, Meredith Akerman, Todd Carpenter, Moses Tam, David Byun, David R. Wise, Anand Mahadevan, Andrew Evans, William Huang, Aaron Katz, Herbert Lepor, Jonathan A. Haas
Percentage of positive cores involved on a systemic prostate biopsy has been established as a risk factor for adverse oncologic outcomes and is a National Comprehensive Cancer Network (NCCN) independent parameter for unfavorable intermediate-risk disease. Most data from a radiation standpoint was published in an era of conventional fractionation. We explore whether the higher biological dose delivered
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Multicenter analysis on the value of standard (chemo)radiotherapy in elderly patients with locally advanced adenocarcinoma of the esophagus or gastroesophageal junction Radiat. Oncol. (IF 3.6) Pub Date : 2024-03-04 Tilman Bostel, Eirini Nikolaidou, Daniel Wollschläger, Arnulf Mayer, Justus Kaufmann, Anne Hopprich, Alexander Rühle, Anca-Ligia Grosu, Jürgen Debus, Christian Fottner, Markus Moehler, Peter Grimminger, Heinz Schmidberger, Nils Henrik Nicolay
To assess the tolerability and oncological results of chemoradiation in elderly patients with locally advanced adenocarcinoma of the esophagus or gastroesophageal junction. This multi-center retrospective analysis included 86 elderly patients (≥ 65 years) with esophageal or gastroesophageal junction adenocarcinoma (median age 73 years; range 65–92 years) treated with definitive or neoadjuvant (chemo)radiotherapy
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Contouring practices and artefact management within a synthetic CT-based radiotherapy workflow for the central nervous system Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-29 Elia Rossi, Sevgi Emin, Michael Gubanski, Giovanna Gagliardi, Mattias Hedman, Fernanda Villegas
The incorporation of magnetic resonance (MR) imaging in radiotherapy (RT) workflows improves contouring precision, yet it introduces geometrical uncertainties when registered with computed tomography (CT) scans. Synthetic CT (sCT) images could minimize these uncertainties and streamline the RT workflow. This study aims to compare the contouring capabilities of sCT images with conventional CT-based/MR-assisted
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Predictive value of delta radiomics in xerostomia after chemoradiotherapy in patients with stage III-IV nasopharyngeal carcinoma Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-28 Mengze Wang, Yuzhen Xi, Luoyu Wang, Haonan Chen, Feng Jiang, Zhongxiang Ding
Xerostomia is one of the most common side effects in nasopharyngeal carcinoma (NPC) patients after chemoradiotherapy. To establish a Delta radiomics model for predicting xerostomia secondary to chemoradiotherapy for NPC based on magnetic resonance T1-weighted imaging (T1WI) sequence and evaluate its diagnostic efficacy. Clinical data and Magnetic resonance imaging (MRI) data before treatment and after
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Efficacy and safety of thoracic radiotherapy in extensive-stage small-cell lung cancer patients receiving first-line immunotherapy plus chemotherapy: a propensity score matched multicentre retrospective analysis Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-27 Yueyuan Yao, Butuo Li, Ruiting Song, Linlin Yang, Bing Zou, Linlin Wang
Platinum-etoposide chemotherapy combined with immune checkpoint inhibitors (ICIs) has been recommended as the first-line standard treatment for extensive-stage small-cell lung cancer (ES-SCLC). However, the effect of thoracic radiotherapy (TRT) on these patients is still unknown. This study aimed to evaluate the efficacy and safety of TRT for ES-SCLC patients who responded to first-line ICIs and chemotherapy
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PLK4 as a potential target to enhance radiosensitivity in triple-negative breast cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-16 Sierra Pellizzari, Vasudeva Bhat, Harjot Athwal, David W. Cescon, Alison L. Allan, Armen Parsyan
Radioresistance is one of the barriers to developing more effective therapies against the most aggressive, triple-negative, breast cancer (TNBC) subtype. In our previous studies, we showed that inhibition of Polo-like Kinase 4 (PLK4) by a novel drug, CFI-400945 significantly enhances the anticancer effects of radiotherapy (RT) compared to single treatment alone. Here we further investigate the role
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Low rate of severe-end-stage kidney disease after SABR for localised primary kidney cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-15 Muhammad Ali, Kendrick Koo, David Chang, Phil Chan, Sheng F. Oon, Daniel Moon, Declan G. Murphy, Renu Eapen, Jeremy Goad, Nathan Lawrentschuk, Arun A. Azad, Sarat Chander, Mark Shaw, Nicholas Hardcastle, Shankar Siva
Stereotactic ablative body radiotherapy (SABR) is an emerging treatment for patients with primary renal cell carcinoma (RCC). However, its impact on renal function is unclear. This study aimed to evaluate incidence and clinical factors predictive of severe to end-stage chronic kidney disease (CKD) after SABR for RCC. This was a Single institutional retrospective analysis of patients with diagnosed
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Review of brachytherapy clinical trials: a cross-sectional analysis of ClinicalTrials.gov Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-13 David Chen, Rod Parsa, Kabir Chauhan, Jelena Lukovic, Kathy Han, Amandeep Taggar, Srinivas Raman
Characterizing the landscape of clinical trials including brachytherapy can provide an overview of the current status and research trends which may guide further areas of investigation. We queried 449,849 clinical trials from the ClinicalTrials.gov registry using brachytherapy-related keywords from 1980 to 2023, yielding 245 multi-arm and 201 single-arm, brachytherapy trials. Multi-arm and single-arm
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Interfractional variation in whole-breast VMAT irradiation: a dosimetric study with complementary SGRT and CBCT patient setup Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-13 M. Mankinen, T. Virén, J. Seppälä, T. Koivumäki
The dosimetric effect of setup uncertainty and tissue deformations in left-sided whole-breast irradiation with complementary surface-guided radiotherapy (SGRT) and cone-beam computed tomography (CBCT) setup was evaluated. Treatment courses of 40.05 Gy prescribed dose in 15 fractions were simulated for 29 patients by calculating the dose on deformed CT images, that were based on daily CBCT images, and
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A 4D-CBCT correction network based on contrastive learning for dose calculation in lung cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-09 Nannan Cao, Ziyi Wang, Jiangyi Ding, Heng Zhang, Sai Zhang, Liugang Gao, Jiawei Sun, Kai Xie, Xinye Ni
This study aimed to present a deep-learning network called contrastive learning-based cycle generative adversarial networks (CLCGAN) to mitigate streak artifacts and correct the CT value in four-dimensional cone beam computed tomography (4D-CBCT) for dose calculation in lung cancer patients. 4D-CBCT and 4D computed tomography (CT) of 20 patients with locally advanced non-small cell lung cancer were
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Dosimetric evaluation of LINAC-based single-isocenter multi-target multi-fraction stereotactic radiosurgery with more than 20 targets: comparing MME, HyperArc, and RapidArc Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-07 Hyunuk Jung, Jihyung Yoon, Olga Dona Lemus, Sean Tanny, Yuwei Zhou, Michael Milano, Kenneth Usuki, Sara Hardy, Dandan Zheng
To compare the dosimetric quality of three widely used techniques for LINAC-based single-isocenter multi-target multi-fraction stereotactic radiosurgery (fSRS) with more than 20 targets: dynamic conformal arc (DCA) in BrainLAB Multiple Metastases Elements (MME) module and volumetric modulated arc therapy (VMAT) using RapidArc (RA) and HyperArc (HA) in Varian Eclipse. Ten patients who received single-isocenter
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Quantitative analysis of the impact of respiratory state on the heartbeat-induced movements of the heart and its substructures Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-05 Benzhe Liang, Guanzhong Gong, Ying Tong, Lizhen Wang, Ya Su, Huadong Wang, Zhenkai Li, Hongyu Yan, Xiaohong Zhang, Yong Yin
This study seeks to examine the influence of the heartbeat on the position, volume, and shape of the heart and its substructures during various breathing states. The findings of this study will serve as a valuable reference for dose-volume evaluation of the heart and its substructures in radiotherapy for treating thoracic tumors. Twenty-three healthy volunteers were enrolled in this study, and cine
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Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study Radiat. Oncol. (IF 3.6) Pub Date : 2024-02-03 Petr Burkon, Iveta Selingerova, Marek Slavik, Milos Holanek, Miroslav Vrzal, Oldrich Coufal, Katerina Polachova, Petr Muller, Pavel Slampa, Tomas Kazda
Accelerated partial breast irradiation (APBI) is an alternative breast-conserving therapy approach where radiation is delivered in less time compared to whole breast irradiation (WBI), resulting in improved patient convenience, less toxicity, and cost savings. This prospective randomized study compares the external beam APBI with commonly used moderate hypofractionated WBI in terms of feasibility,
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Combining a noble gas with radiotherapy: glutamate receptor antagonist xenon may act as a radiosensitizer in glioblastoma Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-30 Thomas Büttner, Marielena K. E. Maerevoet, Frank A. Giordano, Marlon R. Veldwijk, Carsten Herskind, Arne Mathias Ruder
Ionotropic glutamate receptors α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) and N-methyl-D-aspartate receptor (NMDAR) modulate proliferation, invasion and radioresistance in glioblastoma (GB). Pharmacological targeting is difficult as many in vitro-effective agents are not suitable for in patient applications. We aimed to develop a method to test the well tolerated AMPAR-
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Generation of tissues outside the field of view (FOV) of radiation therapy simulation imaging based on machine learning and patient body outline (PBO) Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-25 Sunmi Kim, Lulin Yuan, Siyong Kim, Tae Suk Suh
It is not unusual to see some parts of tissues are excluded in the field of view of CT simulation images. A typical mitigation is to avoid beams entering the missing body parts at the cost of sub-optimal planning. This study is to solve the problem by developing 3 methods, (1) deep learning (DL) mechanism for missing tissue generation, (2) using patient body outline (PBO) based on surface imaging,
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Monte Carlo simulation of the Varian TrueBeam flattened-filtered beams using a surrogate geometry in PRIMO Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-25 Miguel Rodriguez, Josep Sempau, Lorenzo Brualla
Monte Carlo simulation of radiation transport for medical linear accelerators (linacs) requires accurate knowledge of the geometrical description of the linac head. Since the geometry of Varian TrueBeam machines has not been disclosed, the manufacturer distributes phase-space files of the linac patient-independent part to allow researchers to compute absorbed dose distributions using the Monte Carlo
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Cone beam CT-based adaptive intensity modulated proton therapy assessment using automated planning for head-and-neck cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-23 Yihang Xu, William Jin, Michael Butkus, Mariluz De Ornelas, Jonathan Cyriac, Matthew T. Studenski, Kyle Padgett, Garrett Simpson, Stuart Samuels, Michael Samuels, Nesrin Dogan
To assess the feasibility of CBCT-based adaptive intensity modulated proton therapy (IMPT) using automated planning for treatment of head and neck (HN) cancers. Twenty HN cancer patients who received radiotherapy and had pretreatment CBCTs were included in this study. Initial IMPT plans were created using automated planning software for all patients. Synthetic CTs (sCT) were then created by deforming
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Development and validation of survival prognostic models for head and neck cancer patients using machine learning and dosiomics and CT radiomics features: a multicentric study Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-22 Zahra Mansouri, Yazdan Salimi, Mehdi Amini, Ghasem Hajianfar, Mehrdad Oveisi, Isaac Shiri, Habib Zaidi
This study aimed to investigate the value of clinical, radiomic features extracted from gross tumor volumes (GTVs) delineated on CT images, dose distributions (Dosiomics), and fusion of CT and dose distributions to predict outcomes in head and neck cancer (HNC) patients. A cohort of 240 HNC patients from five different centers was obtained from The Cancer Imaging Archive. Seven strategies, including
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ALA-RDT in GBM: protocol of the phase I/II dose escalation trial of radiodynamic therapy with 5-Aminolevulinic acid in patients with recurrent glioblastoma Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-22 Niklas Benedikt Pepper, Hans Theodor Eich, Michael Müther, Michael Oertel, Stephan Rehn, Dorothee Cäcilia Spille, Walter Stummer
Despite improvements in surgical as well as adjuvant therapies over the last decades, the prognosis for patients with glioblastoma remains poor. Five-Aminolevulinic acid (5-ALA) induced porphyrins are already used for fluorescence-guided resection and as photosensitizer for photodynamic therapy. New findings reveal their potential use as sensitizing agents in combination with ionizing radiation. We
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A PET/CT radiomics model for predicting distant metastasis in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy: a multicentric study Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-22 Lu Yu, Zhen Zhang, HeQing Yi, Jin Wang, Junyi Li, Xiaofeng Wang, Hui Bai, Hong Ge, Xiaoli Zheng, Jianjiao Ni, Haoran Qi, Yong Guan, Wengui Xu, Zhengfei Zhu, Ligang Xing, Andre Dekker, Leonard Wee, Alberto Traverso, Zhaoxiang Ye, Zhiyong Yuan
Stereotactic body radiotherapy (SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit for surgery. Some patients may experience distant metastasis. This study aimed to develop and validate a radiomics model for predicting distant metastasis in patients with early-stage NSCLC treated with SBRT. Patients at five institutions were enrolled in this study
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Evolution of radiation-induced temporal lobe injury after intensity-modulated radiation therapy in nasopharyngeal carcinoma: a large cohort retrospective study Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-19 Jing Hou, Yun He, Handong Li, Zhaodong Ai, Qiang Lu, Biao Zeng, Chuanmiao Xie, Xiaoping Yu
Previous studies have demonstrated conflicting findings regarding the initial MRI patterns of radiotherapy-induced temporal lobe injury (RTLI) and the evolution of different RTLI patterns. The aim of this study was to evaluate the initial MRI pattern and evolution of RTLI in patients with nasopharyngeal carcinoma (NPC) by means of a large cohort study. Data of patients with RTLI were retrospectively
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Is radiotherapy necessary for upper rectal cancer underwent curative resection? A retrospective study of 363 patients Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-18 Zhiwei Ma, Jumei Zhou, Ke Liu, Sisi Chen, Qinghui Wu, Lin Peng, Wei Zhao, Suyu Zhu
To investigate the impact of radiotherapy (RT) on recurrence and survival in patients with locally advanced upper rectal cancer underwent curative resection. 363 locally advanced upper rectal cancer cases were identified from the database of our hospital from 2010 to 2018. All patients underwent curative resection and had the lower margin of the tumor located 10–15 cm from the anal verge, among them
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The radiation- and chemo-sensitizing capacity of diclofenac can be predicted by a decreased lactate metabolism and stress response Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-16 Melissa Schwab, Ali Bashiri Dezfouli, Mohammad Khosravi, Bayan Alkotub, Lisa Bauer, Mohammad Javed Tahmasebi Birgani, Gabriele Multhoff
An enhanced aerobic glycolysis (“Warburg effect”) associated with an increase in lactic acid in the tumor microenvironment contributes to tumor aggressiveness and resistance to radiation and chemotherapy. We investigated the radiation- and chemo-sensitizing effects of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac in different cancer cell types. The effects of a non-lethal concentration
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Prospects for daily online adaptive radiotherapy for cervical cancer: Auto-contouring evaluation and dosimetric outcomes Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-12 Yu Zhang, Guangyu Wang, Yankui Chang, Zhiqun Wang, Xiansong Sun, Yuliang Sun, Zheng Zeng, Yining Chen, Ke Hu, Jie Qiu, Junfang Yan, Fuquan Zhang
Training senior radiation therapists as “adapters” to manage influencers and target editing is critical in daily online adaptive radiotherapy (oART) for cervical cancer. The purpose of this study was to evaluate the accuracy and dosimetric outcomes of automatic contouring and identify the key areas for modification. A total of 125 oART fractions from five postoperative cervical cancer patients and
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Using meta-analysis and CNN-NLP to review and classify the medical literature for normal tissue complication probability in head and neck cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-09 Tsair-Fwu Lee, Yang-Wei Hsieh, Pei-Ying Yang, Chi-Hung Tseng, Shen-Hao Lee, Jack Yang, Liyun Chang, Jia-Ming Wu, Chin-Dar Tseng, Pei-Ju Chao
The study aims to enhance the efficiency and accuracy of literature reviews on normal tissue complication probability (NTCP) in head and neck cancer patients using radiation therapy. It employs meta-analysis (MA) and natural language processing (NLP). The study consists of two parts. First, it employs MA to assess NTCP models for xerostomia, dysphagia, and mucositis after radiation therapy, using Python
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Prospects for online adaptive radiation therapy (ART) for head and neck cancer Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-08 Maja Guberina, Nika Guberina, C. Hoffmann, A. Gogishvili, F. Freisleben, A. Herz, J. Hlouschek, T. Gauler, S. Lang, K. Stähr, B. Höing, C. Pöttgen, F. Indenkämpen, A. Santiago, A. Khouya, S. Mattheis, M. Stuschke
The aim of the present study is to examine the impact of kV-CBCT-based online adaptive radiation therapy (ART) on dosimetric parameters in comparison to image-guided-radiotherapy (IGRT) in consecutive patients with tumors in the head and neck region from a prospective registry. The study comprises all consecutive patients with tumors in the head and neck area who were treated with kV-CBCT-based online
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Comparison of deep learning networks for fully automated head and neck tumor delineation on multi-centric PET/CT images Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-08 Yiling Wang, Elia Lombardo, Lili Huang, Michele Avanzo, Giuseppe Fanetti, Giovanni Franchin, Sebastian Zschaeck, Julian Weingärtner, Claus Belka, Marco Riboldi, Christopher Kurz, Guillaume Landry
Deep learning-based auto-segmentation of head and neck cancer (HNC) tumors is expected to have better reproducibility than manual delineation. Positron emission tomography (PET) and computed tomography (CT) are commonly used in tumor segmentation. However, current methods still face challenges in handling whole-body scans where a manual selection of a bounding box may be required. Moreover, different
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Evaluation of PTV margins with daily iterative online adaptive radiotherapy for postoperative treatment of endometrial and cervical cancer: a prospective single-arm phase 2 study Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-04 Guangyu Wang, Zhiqun Wang, Yuping Guo, Yu Zhang, Jie Qiu, Ke Hu, Jing Li, JunFang Yan, Fuquan Zhang
To determine the optimal planning target volume (PTV) margins for adequate coverage by daily iterative cone-beam computed tomography (iCBCT)-guided online adaptive radiotherapy (oART) in postoperative treatment of endometrial and cervical cancer and the benefit of reducing PTV margins. Fifteen postoperative endometrial and cervical cancer patients treated with daily iCBCT-guided oART were enrolled
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Stereotactic body radiotherapy for early-stage lung cancer: a systematic review on the choice of photon energy and linac flattened/unflattened beams Radiat. Oncol. (IF 3.6) Pub Date : 2024-01-02 Ashlesha Gill, Andrew L Hirst, Pejman Rowshanfarzad, Suki Gill, Nicholas Bucknell, Joshua Dass, Mahsheed Sabet
SBRT is an effective local treatment for patients with early-stage non-small cell lung cancer (NSCLC). This treatment is currently used in patients who have poor lung function or who decline surgery. As SBRT usually has small PTV margins, reducing the beam-on-time (BOT) is beneficial for accurate dose delivery by minimising intrafraction motion as well as improved patient comfort. Removal of the linear
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Hemostatic radiotherapy in clinically significant tumor-related bleeding: excellent palliative results in a retrospective analysis of 77 patients Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-20 Manuel Guhlich, Teresa Esther Maag, Leif Hendrik Dröge, Andrea Hille, Sandra Donath, Stephanie Bendrich, Markus Anton Schirmer, Friedemann Nauck, Martin Leu, Joachim Riggert, Julia Gallwas, Stefan Rieken
Significant bleeding of tumor sites is a dreaded complication in oncological diseases and often results in clinical emergencies. Besides basic local and interventional procedures, an urgent radiotherapeutic approach can either achieve a bleeding reduction or a bleeding stop in a vast majority of patients. In spite of being used regularly in clinical practice, data reporting results to this therapy
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Stereotactic radiosurgery of brain metastases: a retrospective study Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-19 Isabella Gruber, Karin Weidner, Marius Treutwein, Oliver Koelbl
Single-fraction stereotactic radiosurgery (SRS) is an established standard for radiation therapy of brain metastases although recent developments indicate that multi-fractionated stereotactic radiotherapy (FSRT) results in lower radiation necrosis especially for larger metastases, and the same or even better local control in comparison to SRS. Seventy-two patients with 111 brain metastases received
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Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-18 Teruaki Mizobuchi, Akihiro Nomoto, Hironobu Wada, Naoyoshi Yamamoto, Mio Nakajima, Takehiko Fujisawa, Hidemi Suzuki, Ichiro Yoshino
This study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were treated with carbon ion radiotherapy (CIRT) versus segmentectomy. A retrospective review of medical records was conducted. The study included 123 cases of clinical stage 0/IA peripheral NSCLC treated with single-fraction CIRT from 2003 to 2012, 14 of which were determined
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Comparing breath hold versus free breathing irradiation for left-sided breast radiotherapy by PlanIQ™ Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-14 Ke Yuan, Xinghong Yao, Xiongfei Liao, Pen Diao, Xin Xin, Jiabao Ma, Jie Li, Lucia Clara Orlandini
Breast cancer is the most widespread cancer in women and young women worldwide. Moving towards customised radiotherapy, balancing the use of the available technology with the best treatment modality may not be an easy task in the daily routine. This study aims to evaluate the effectiveness of introducing IQ-feasibility into clinical practice to support the decision of free-breathing (FB) versus breath-hold
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Correction: Palliative radiotherapy for tumor bleeding in patients with unresectable pancreatic cancer: a single-center retrospective study Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-12 Taro Shibuki, Mitsuhito Sasaki, Shota Yamaguchi, Kanae Inoue, Tomonao Taira, Tomoyuki Satake, Kazuo Watanabe, Hiroshi Imaoka, Shuichi Mitsunaga, Takeshi Fujisawa, Kento Tomizawa, Hidekazu Oyoshi, Masaki Nakamura, Hidehiro Hojo, Masafumi Ikeda
Radiation Oncology (2023) 18:178 https://doi.org/10.1186/s13014-023-02367-5 After publication of this article [1], the authors reported that in this article the graphics relating to Figs. 1, 2, 3 and 4 captions had been interchanged; the figures should have appeared as shown below. Fig. 1 A Typical clinical target volume (red line) and planning target volume (purple line). B Dose distribution with
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Histopathologically confirmed radiation-induced damage of the brain – an in-depth analysis of radiation parameters and spatio-temporal occurrence Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-12 Mario R. P. Kossmann, Felix Ehret, Siyer Roohani, Sebastian F. Winter, Pirus Ghadjar, Güliz Acker, Carolin Senger, Simone Schmid, Daniel Zips, David Kaul
Radiation-induced damage (RID) after radiotherapy (RT) of primary brain tumors and metastases can be challenging to clinico-radiographically distinguish from tumor progression. RID includes pseudoprogression and radiation necrosis; the latter being irreversible and often associated with severe symptoms. While histopathology constitutes the diagnostic gold standard, biopsy-controlled clinical studies
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Concomitant radiosurgical and targeted oncological treatment improves the outcome of patients with brain metastases from gastrointestinal cancer Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-09 Farjad Khalaveh, Anna Cho, Abdallah Shaltout, Helena Untersteiner, Beate Kranawetter, Dorian Hirschmann, Philipp Göbl, Wolfgang Marik, Brigitte Gatterbauer, Karl Rössler, Christian Dorfer, Josa M. Frischer
So far, only limited studies exist that evaluate patients with brain metastases (BM) from GI cancer and associated primary cancers who were treated by Gamma Knife Radiosurgery (GKRS) and concomitant immunotherapy (IT) or targeted therapy (TT). Survival after GKRS was compared to the general and specific Graded Prognostic Assessment (GPA) and Score Index for Radiosurgery (SIR). Further, the influence
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Retrospective analysis of the 18F-FDG PET/CT cutoff value for metabolic parameters was performed as a prediction model to evaluate risk factors for endometrial cancer Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-04 Ye Yang, Yu-Qin Pan, Min Wang, Song Gu, Wei Bao
The study retrospectively analyzed the accuracy and predictive ability of preoperative integrated whole-body 18F-FDG PET/CT for the assessment of high-risk factors in patients with endometrial carcinoma (EC). A total of 205 patients with endometrial cancer who underwent preoperative PET/CT at Shanghai General Hospital from January 2018 to December 2021 were retrospectively evaluated and last follow-up
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Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis Radiat. Oncol. (IF 3.6) Pub Date : 2023-12-01 Ningyi Ma, Xue Ming, Jian Chen, Kai-Liang Wu, Jiade Lu, Guoliang Jiang, Jingfang Mao
Concurrent chemoradiotherapy has been standard of care for unresectable esophageal carcinoma. There were no reports on proton radiotherapy (PRT) plus carbon-ion radiotherapy (CIRT) with pencil beam scanning (PBS) for esophageal carcinoma. This study evaluated the tolerability and efficiency of proton and sequential carbon-ion boost radiotherapy for esophageal carcinoma. From April 2017 to July 2020